"seqid"	"somaid"	"target"	"targetfull"	"chr"	"start"	"end"	"entrezgenesymbol"	"entrezgeneid"	"uniprotid"	"pathways_wiki"	"pathways_pid"	"pathways_uni"	"pathways_reactome"	"pathways_studio"	"ipa_drugs"	"ipa_applications"	"uniprotcomment"	"locus"	"network"
"2182-54_1"	"SL000318"	"C4b"	"Complement C4b"	"6"	"31969570"	"32111862"	"C4A|C4B"	"720|721"	"P0C0L4|P0C0L5"	"Complement Activation, Classical Pathway|SIDS Susceptibility Pathways"	""	""	"Activation of C3 and C5|Initial triggering of complement|Regulation of Complement cascade"	""	""	""	"Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.|Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens."	"137|379"	"TRUE"
"2190-55_1"	"SL002662"	"Coagulation Factor XI"	"Coagulation Factor XI"	"4"	"186265945"	"186288806"	"F11"	"2160"	"P03951"	"Blood Clotting Cascade"	""	""	"Intrinsic Pathway of Fibrin Clot Formation"	"Coagulation Cascade"	""	""	"Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX."	"96|164|391"	"TRUE"
"2192-63_10"	"SL003168"	"CTACK"	"C-C motif chemokine 27"	"9"	"34661880"	"34664048"	"CCL27"	"10850"	"Q9Y4X3"	""	""	""	"Chemokine receptors bind chemokines|G alpha (i) signalling events"	""	""	""	"Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10."	""	"TRUE"
"2201-17_6"	"SL000403"	"Endostatin"	"Endostatin"	"21"	"45405137"	"45513720"	"COL18A1"	"80781"	"P39060"	""	"Beta1 integrin cell surface interactions|Direct p53 effectors|FOXA1 transcription factor network|Validated nuclear estrogen receptor alpha network"	""	"Activation of Matrix Metalloproteinases|Assembly of collagen fibrils and other multimeric structures|Collagen biosynthesis and modifying enzymes|Collagen degradation|Integrin cell surface interactions|Laminin interactions"	"VEGFR -> AP-1/CREB/MYC signaling|VEGFR -> ATF/CREB/ELK-SRF signaling|VEGFR -> CTNNB signaling|VEGFR -> CTNND signaling|VEGFR -> FOXO3A signaling|VEGFR -> NFATC signaling|VEGFR -> STAT signaling"	"collagenase clostridium histolyticum"	"diagnosis"	"COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube."	""	"TRUE"
"2211-9_6"	"SL000591"	"TIMP-1"	"Metalloproteinase inhibitor 1"	"X"	"47582313"	"47586789"	"TIMP1"	"7076"	"P01033"	"IL-6 signaling pathway|Matrix Metalloproteinases"	"AP-1 transcription factor network|IL6-mediated signaling events"	""	"Activation of Matrix Metalloproteinases|Platelet degranulation"	"Extracellular Matrix Turnover"	""	"diagnosis|disease progression|efficacy|prognosis|unspecified application"	"Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors."	""	"TRUE"
"2212-69_1"	"SL000053"	"tPA"	"Tissue-type plasminogen activator"	"8"	"42175233"	"42207724"	"PLAT"	"5327"	"P00750"	"Blood Clotting Cascade|Complement and Coagulation Cascades|Endochondral Ossification|Folate Metabolism|Selenium Pathway|Senescence and Autophagy|Vitamin B12 Metabolism"	"Beta2 integrin cell surface interactions|amb2 Integrin signaling"	""	"Dissolution of Fibrin Clot|Signaling by PDGF"	"Coagulation Cascade"	"6-aminocaproic acid"	"diagnosis|efficacy|prognosis|safety|unspecified application"	"Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration."	""	"TRUE"
"2247-20_11"	"SL004332"	"EG-VEGF"	"Prokineticin-1"	"1"	"110451200"	"110457354"	"PROK1"	"84432"	"P58294"	""	""	""	"G alpha (q) signalling events|Peptide ligand-binding receptors"	""	""	""	"Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis."	""	"TRUE"
"2278-61_4"	"SL000592"	"TIMP-2"	"Metalloproteinase inhibitor 2"	"17"	"78852977"	"78925387"	"TIMP2"	"7077"	"P16035"	"Angiogenesis|Matrix Metalloproteinases|angiogenesis overview"	""	""	"Activation of Matrix Metalloproteinases"	"Extracellular Matrix Turnover"	""	"efficacy|unspecified application"	"Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19."	""	"TRUE"
"2333-72_1"	"SL000584"	"TGF-b1"	"Transforming growth factor beta-1"	"19"	"41301587"	"41353911"	"TGFB1"	"7040"	"P01137"	"ACE Inhibitor Pathway|Adipogenesis|Cell cycle|Cytokines and Inflammatory Response|DNA damage response (only ATM dependent)|Endochondral Ossification|Epithelium TarBase|IL-3 Signaling Pathway|Leukocyte TarBase|Lymphocyte TarBase|MAPK signaling pathway|MicroRNAs in cardiomyocyte hypertrophy|Proteins and DNA Sequences in Cardicac Structures|Senescence and Autophagy|Squamous cell  TarBase|TCR Signaling Pathway|TFs Regulate miRNAs related to cardiac hypertrophy|TGF Beta Signaling Pathway|TGF beta Signaling Pathway"	"ALK1 signaling events|AP-1 transcription factor network|Glypican 1 network|IL12 signaling mediated by STAT4|IL27-mediated signaling events|RXR and RAR heterodimerization with other nuclear receptor|Regulation of Telomerase|Syndecan-1-mediated signaling events|Syndecan-2-mediated signaling events|TGF-beta receptor signaling|Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling"	""	"Downregulation of TGF-beta receptor signaling|ECM proteoglycans|Influenza Virus Induced Apoptosis|Molecules associated with elastic fibres|Platelet degranulation|SMAD2/3 MH2 Domain Mutants in Cancer|SMAD2/3 Phosphorylation Motif Mutants in Cancer|Syndecan interactions|TGF-beta receptor signaling activates SMADs|TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)|TGFBR1 KD Mutants in Cancer|TGFBR1 LBD Mutants in Cancer|TGFBR2 Kinase Domain Mutants in Cancer|TGFBR2 MSI Frameshift Mutants in Cancer|Transcriptional regulation of white adipocyte differentiation"	"Activation of Immunoglobulin Class-Switch Recombination|Cell Cycle|MDK/PTN Expression Targets|Regulatory T-cell Differentiation|TGFBR -> AP-1 signaling|TGFBR -> ATF/GADD/MAX/TP53 signaling|TGFBR -> CREB/ELK-SRF signaling|TGFBR -> MEF/MYOD/MYOG signaling|TGFBR -> SMAD1/5/9 signaling|TGFBR/BMPR -> SMAD2/3 signaling|TLR4 Signaling in Leukocytes|Th17 Cell Differentiation"	""	"diagnosis|efficacy|prognosis|safety|unspecified application"	"Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells. Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus (PubMed:25893292). Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types (PubMed:25893292)."	""	"TRUE"
"2358-19_2"	"SL003322"	"VEGF sR3"	"Vascular endothelial growth factor receptor 3"	"5"	"180601506"	"180649624"	"FLT4"	"2324"	"P35916"	""	"VEGF and VEGFR signaling network|VEGFR3 signaling in lymphatic endothelium"	""	"VEGF binds to VEGFR leading to receptor dimerization"	"VEGFR -> AP-1/CREB/MYC signaling|VEGFR -> ATF/CREB/ELK-SRF signaling|VEGFR -> CTNNB signaling|VEGFR -> FOXO3A signaling"	"sunitinib|pazopanib|axitinib|CEP 7055|tivozanib|motesanib|telatinib|cabozantinib|nintedanib|regorafenib|bortezomib/sorafenib|dexamethasone/lenalidomide/sorafenib|bevacizumab/sorafenib|cabozantinib/erlotinib|sorafenib|vandetanib"	"diagnosis|disease progression|efficacy|prognosis"	"Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'."	"28|52|69|360|429"	"TRUE"
"2381-52_4"	"SL000319"	"C5"	"Complement C5"	"9"	"120952335"	"121050276"	"C5"	"727"	"P01031"	"Complement Activation, Classical Pathway"	""	""	"Activation of C3 and C5|G alpha (i) signalling events|Peptide ligand-binding receptors|Regulation of Complement cascade|Terminal pathway of complement"	"Alternative Complement Pathway|Classical Complement Pathway|Lectin-Induced Complement Pathway"	"eculizumab|IgG"	""	"Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled."	""	"TRUE"
"2418-55_9"	"SL000276"	"Apo E"	"Apolipoprotein E"	"19"	"44905754"	"44909393"	"APOE"	"348"	"P02649"	"Alzheimers Disease|Statin Pathway|Vitamin B12 Metabolism"	""	""	"Chylomicron-mediated lipid transport|HDL-mediated lipid transport|Retinoid metabolism and transport|Scavenging by Class A Receptors"	""	""	"diagnosis|efficacy|prognosis|unspecified application"	"Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues."	""	"TRUE"
"2421-7_3"	"SL003951"	"BDNF"	"Brain-derived neurotrophic factor"	"11"	"27654893"	"27722058"	"BDNF"	"627"	"P23560"	"FSH signaling pathway|Lymphocyte TarBase|MAPK signaling pathway"	"Neurotrophic factor-mediated Trk receptor signaling|Posttranslational regulation of adherens junction stability and dissassembly|SHP2 signaling|p75(NTR)-mediated signaling"	""	""	"GFs/TNF -> ion channels|NGFR -> AP-1/CEBPB/CREB/ELK-SRF/TP53 signaling|NGFR -> MEF signaling|NGFR -> NF-kB signaling|NMDA receptors -> Ca2+/CREB activation/PGE2 synthesis|NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling|NTRK -> FOXO/MYCN signaling|NTRK1/2/3 -> acetylcholine production|Nociception-related DRD2 expression targets|PTGER2/3 -> inflammation-related expression targets|Regulation of calcium flux|Summarized nociception-related expression targets"	""	"efficacy|response to therapy"	"During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability."	""	"TRUE"
"2424-69_4"	"SL003060"	"bFGF-R"	"Fibroblast growth factor receptor 1"	"8"	"38411138"	"38468834"	"FGFR1"	"2260"	"P11362"	"NA"	"NA"	"NA"	"NA"	"NA"	"pazopanib|nintedanib|regorafenib|bortezomib/sorafenib|dexamethasone/lenalidomide/sorafenib|sorafenib"	"diagnosis|prognosis|unspecified application"	"Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation."	""	"TRUE"
"2429-27_4"	"SL000324"	"C8"	"Complement component C8"	"1|9"	"56854806|136945246"	"56966140|136946974"	"C8A|C8B|C8G"	"731|732|733"	"P07357|P07358|P07360"	"Complement Activation, Classical Pathway"	""	""	"Regulation of Complement cascade|Terminal pathway of complement"	""	""	""	"Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself.|Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.|C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol."	"365"	"TRUE"
"2431-17_3"	"SL000345"	"Cathepsin G"	"Cathepsin G"	"14"	"24573522"	"24576260"	"CTSG"	"1511"	"P08311"	"ACE Inhibitor Pathway"	"Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling"	""	"Activation of Matrix Metalloproteinases|Degradation of the extracellular matrix|Metabolism of Angiotensinogen to Angiotensins|Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"	""	""	"response to therapy"	"Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride."	""	"TRUE"
"2436-49_4"	"SL004016"	"CXCL16, soluble"	"C-X-C motif chemokine 16"	"17"	"4733526"	"4739922"	"CXCL16"	"58191"	"Q9H2A7"	""	""	""	"Chemokine receptors bind chemokines|G alpha (i) signalling events"	""	""	"diagnosis|disease progression|unspecified application"	"Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo."	""	"TRUE"
"2441-2_4"	"SL004333"	"FGF-10"	"Fibroblast growth factor 10"	"5"	"44303544"	"44389706"	"FGF10"	"2255"	"O15520"	"Heart Development|Proteins and DNA Sequences in Cardicac Structures|Regulation of Actin Cytoskeleton"	""	""	"Activated point mutants of FGFR2|Constitutive Signaling by Aberrant PI3K in Cancer|FGFR1b ligand binding and activation|FGFR2b ligand binding and activation|FRS-mediated FGFR1 signaling|FRS-mediated FGFR2 signaling|Negative regulation of FGFR1 signaling|Negative regulation of FGFR2 signaling|PI-3K cascade:FGFR1|PI-3K cascade:FGFR2|PI3K Cascade|PIP3 activates AKT signaling|Phospholipase C-mediated cascade, FGFR2|Phospholipase C-mediated cascade: FGFR1|Regulation of gene expression in early pancreatic precursor cells|SHC-mediated cascade:FGFR1|SHC-mediated cascade:FGFR2|Signaling by FGFR2 mutants|Signaling by FGFR4 mutants"	"FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling|FGFR -> RUNX2 signaling|FGFR1 -> STAT signaling"	""	""	"Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing."	""	"TRUE"
"2443-10_4"	"SL004342"	"FGF-8B"	"Fibroblast growth factor 8 isoform B"	"10"	"101770130"	"101780369"	"FGF8"	"2253"	"P55075"	"Heart Development|Neural Crest Differentiation|Proteins and DNA Sequences in Cardicac Structures|Regulation of Actin Cytoskeleton"	"FGF signaling pathway"	""	"Activated point mutants of FGFR2|Constitutive Signaling by Aberrant PI3K in Cancer|FGFR1c ligand binding and activation|FGFR2c ligand binding and activation|FGFR3 mutant receptor activation|FGFR3b ligand binding and activation|FGFR3c ligand binding and activation|FGFR4 ligand binding and activation|FRS-mediated FGFR1 signaling|FRS-mediated FGFR2 signaling|FRS-mediated FGFR3 signaling|FRS2-mediated FGFR4 signaling|Negative regulation of FGFR1 signaling|Negative regulation of FGFR2 signaling|Negative regulation of FGFR3 signaling|Negative regulation of FGFR4 signaling|PI-3K cascade:FGFR1|PI-3K cascade:FGFR2|PI-3K cascade:FGFR3|PI-3K cascade:FGFR4|PI3K Cascade|PIP3 activates AKT signaling|Phospholipase C-mediated cascade, FGFR2|Phospholipase C-mediated cascade, FGFR3|Phospholipase C-mediated cascade, FGFR4|Phospholipase C-mediated cascade: FGFR1|SHC-mediated cascade:FGFR1|SHC-mediated cascade:FGFR2|SHC-mediated cascade:FGFR3|SHC-mediated cascade:FGFR4|Signaling by FGFR1 mutants|Signaling by FGFR2 mutants|Signaling by FGFR3 mutants|Signaling by FGFR4 mutants|Signaling by activated point mutants of FGFR1|Signaling by activated point mutants of FGFR3"	"FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling|FGFR -> RUNX2 signaling|FGFR3 -> STAT signaling"	""	""	"Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system (PubMed:16384934, PubMed:16597617, PubMed:8663044). Plays a role in neurite outgrowth in hippocampal cells (PubMed:21576111)."	""	"TRUE"
"2447-7_4"	"SL004066"	"GIIE"	"Group IIE secretory phospholipase A2"	"1"	"19920009"	"19923617"	"PLA2G2E"	"30814"	"Q9NZK7"	""	""	""	"Acyl chain remodelling of PC|Acyl chain remodelling of PE|Acyl chain remodelling of PG|Acyl chain remodelling of PI|Acyl chain remodelling of PS|Synthesis of PA"	""	""	"unspecified application"	"PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids."	""	"TRUE"
"2449-1_4"	"SL004182"	"GV"	"Calcium-dependent phospholipase A2"	"1"	"20028179"	"20091190"	"PLA2G5"	"5322"	"P39877"	"MAPK signaling pathway"	""	""	"Acyl chain remodelling of PC|Acyl chain remodelling of PE|Acyl chain remodelling of PG|Acyl chain remodelling of PI|Acyl chain remodelling of PS|Synthesis of PA"	""	"varespladib methyl|varespladib"	""	"PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes more efficiently L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L-alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine, or L-alpha-1-stearoyl-2-arachidonyl phosphatidylinositol. May be involved in the production of lung surfactant, the remodeling or regulation of cardiac muscle."	""	"TRUE"
"2455-17_4"	"SL001716"	"IL-12"	"Interleukin-12"	"3|5"	"159988750|159314783"	"159996019|159330887"	"IL12A|IL12B"	"3592|3593"	"P29459|P29460"	"NA"	"NA"	"NA"	"NA"	"NA"	""	""	"Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.|Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC."	""	"TRUE"
"2468-62_3"	"SL000133"	"MIP-3a"	"C-C motif chemokine 20"	"2"	"227813842"	"227817564"	"CCL20"	"6364"	"P78556"	"EBV LMP1 signaling"	""	""	"Chemokine receptors bind chemokines|G alpha (i) signalling events"	""	""	""	"Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E.coli ATCC 25922 and S.aureus ATCC 29213."	""	"TRUE"
"2474-54_5"	"SL000573"	"SAP"	"Serum amyloid P-component"	"1"	"159587825"	"159588865"	"APCS"	"325"	"P02743"	""	""	""	"Amyloids"	""	""	"unspecified application"	"Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin."	"444"	"TRUE"
"2475-1_3"	"SL004010"	"SCF sR"	"Mast/stem cell growth factor receptor Kit"	"4"	"54657918"	"54740715"	"KIT"	"3815"	"P10721"	"Epithelium TarBase|Kit receptor signaling pathway|Lymphocyte TarBase|Muscle cell TarBase"	"C-MYB transcription factor network|Signaling events mediated by Stem cell factor receptor (c-Kit)"	""	"Constitutive Signaling by Aberrant PI3K in Cancer|PIP3 activates AKT signaling|Regulation of KIT signaling|Signaling by SCF-KIT"	"KIT -> MITF signaling|KIT -> STAT signaling"	"dasatinib|sunitinib|pazopanib|tivozanib|motesanib|OSI-930|telatinib|tandutinib|cabozantinib|regorafenib|ponatinib|bortezomib/sorafenib|lapatinib/pazopanib|dexamethasone/lenalidomide/sorafenib|bevacizumab/sorafenib|imatinib/sirolimus|cabozantinib/erlotinib|imatinib/nilotinib/pegintron|imatinib|sorafenib"	"diagnosis|efficacy|prognosis|safety|unspecified application"	"Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1."	""	"TRUE"
"2480-58_3"	"SL003043"	"TIMP-3"	"Metalloproteinase inhibitor 3"	"22"	"32801701"	"32863043"	"TIMP3"	"7078"	"P35625"	"Angiogenesis|Endochondral Ossification|Matrix Metalloproteinases"	""	""	""	"Extracellular Matrix Turnover"	""	"diagnosis|prognosis|unspecified application"	"Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15."	"27|193|225|327|336|431"	"TRUE"
"2484-49_3"	"SL004365"	"TWEAK"	"Tumor necrosis factor ligand superfamily member 12"	"17"	"7548891"	"7557890"	"TNFSF12"	"8742"	"O43508"	"NA"	"NA"	"NA"	"NA"	"NA"	""	"unspecified application"	"Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion."	""	"TRUE"
"2500-2_3"	"SL004643"	"Angiopoietin-4"	"Angiopoietin-4"	"20"	"869899"	"916317"	"ANGPT4"	"51378"	"Q9Y264"	""	"Angiopoietin receptor Tie2-mediated signaling"	""	"Tie2 Signaling"	"AngiopoietinR -> FOXO signaling|AngiopoietinR -> STAT signaling"	""	""	"Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis."	""	"TRUE"
"2501-51_3"	"SL000055"	"Cadherin E"	"Cadherin-1"	"16"	"68737225"	"68835548"	"CDH1"	"999"	"P12830"	"Cell cycle|Integrated Breast Cancer Pathway|Neural Crest Differentiation"	"AlphaE beta7 integrin cell surface interactions|Arf6 trafficking events|CDC42 signaling events|E-cadherin signaling events|E-cadherin signaling in keratinocytes|E-cadherin signaling in the nascent adherens junction|FGF signaling pathway|Nectin adhesion pathway|Posttranslational regulation of adherens junction stability and dissassembly|RAC1 signaling pathway|Regulation of nuclear beta catenin signaling and target gene transcription|Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)|Stabilization and expansion of the E-cadherin adherens junction|a6b1 and a6b4 Integrin signaling"	""	"Adherens junctions interactions|Apoptotic cleavage of cell adhesion proteins|Degradation of the extracellular matrix|Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell|Integrin cell surface interactions|RHO GTPases activate IQGAPs"	"Adherens Junction Assembly (Cadherins)|Desmosome Assembly"	""	"diagnosis|disease progression|efficacy|prognosis"	"Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7."	""	"TRUE"
"2505-49_3"	"SL004144"	"GFRa-3"	"GDNF family receptor alpha-3"	"5"	"138252379"	"138274671"	"GFRA3"	"2676"	"O60609"	""	""	""	""	""	""	""	"Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase."	""	"TRUE"
"2514-65_3"	"SL004142"	"Ephrin-B3"	"Ephrin-B3"	"17"	"7705202"	"7711378"	"EFNB3"	"1949"	"Q15768"	""	"EPHB forward signaling"	""	"EPH-Ephrin signaling|EPH-ephrin mediated repulsion of cells|EPHB-mediated forward signaling|Ephrin signaling"	"EphrinR -> STAT signaling|EphrinR -> actin signaling"	""	""	"Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity)."	""	"TRUE"
"2515-14_3"	"SL004143"	"GFRa-2"	"GDNF family receptor alpha-2"	"8"	"21690403"	"21812357"	"GFRA2"	"2675"	"O00451"	""	""	""	"NCAM1 interactions"	""	""	""	"Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor."	"204|440"	"TRUE"
"2516-57_3"	"SL003193"	"6Ckine"	"C-C motif chemokine 21"	"9"	"34709005"	"34710124"	"CCL21"	"6366"	"O00585"	""	""	""	"Chemokine receptors bind chemokines|G alpha (i) signalling events"	""	""	"disease progression"	"Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4."	"352"	"TRUE"
"2523-31_3"	"SL000563"	"RANTES"	"C-C motif chemokine 5"	"17"	"35871491"	"35880793"	"CCL5"	"6352"	"P13501"	"NA"	"NA"	"NA"	"NA"	"NA"	""	"diagnosis|efficacy|unspecified application"	"Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:16791620, PubMed:1380064, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485)."	"449"	"TRUE"
"2524-56_3"	"SL003280"	"HMG-1"	"High mobility group protein B1"	"13"	"30456704"	"30617597"	"HMGB1"	"3146"	"P09429"	"DNA damage response (only ATM dependent)"	"Beta3 integrin cell surface interactions|Endogenous TLR signaling|amb2 Integrin signaling"	""	"Activation of DNA fragmentation factor|Advanced glycosylation endproduct receptor signaling|DEx/H-box helicases activate type I IFN and inflammatory cytokines production|RIP-mediated NFkB activation via ZBP1|TAK1 activates NFkB by phosphorylation and activation of IKKs complex|TRAF6 mediated NF-kB activation"	"AGER ->  CREB/SP1 signaling|AGER ->  NF-kB signaling"	""	"diagnosis"	"Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23519706, PubMed:23446148, PubMed:23994764, PubMed:25048472). Has proangiogdenic activity (By similarity). May be involved in platelet activation (By similarity). Binds to phosphatidylserine and phosphatidylethanolamide (By similarity). Bound to RAGE mediates signaling for neuronal outgrowth (By similarity). May play a role in accumulation of expanded polyglutamine (polyQ) proteins such as huntingtin (HTT) or TBP (PubMed:23303669, PubMed:25549101)."	""	"TRUE"
"2526-53_3"	"SL002539"	"OPG"	"Tumor necrosis factor receptor superfamily member 11B"	"8"	"118923557"	"118952200"	"TNFRSF11B"	"4982"	"O00300"	"Apoptosis Modulation and Signaling|Monoamine Transport|Osteoblast Signaling|Osteoclast Signaling|RANKL/RANK Signaling Pathway"	""	""	""	"Nociception-related IL1B expression targets"	""	"diagnosis|efficacy"	"Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis."	""	"TRUE"
"2558-51_3"	"SL000300"	"b-Endorphin"	"Beta-endorphin"	"2"	"25160853"	"25168903"	"POMC"	"5443"	"P01189"	""	"Glucocorticoid receptor regulatory network|Syndecan-3-mediated signaling events"	""	"Androgen biosynthesis|Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)|Endogenous sterols|G alpha (i) signalling events|G alpha (s) signalling events|G-protein activation|Glucocorticoid biosynthesis|Opioid Signalling|Peptide hormone biosynthesis|Peptide ligand-binding receptors"	"CRH -> synthesis of corticosteroids|GALR1/2/3 -> POMC/NPY production|NPY1R -> CRH/POMC production|Nociception-related IL1B expression targets|OpioidR -> CREB/ELK-SRF/STAT3 signaling|Summarized nociception-related expression targets"	""	"diagnosis|efficacy|unspecified application"	"ACTH stimulates the adrenal glands to release cortisol."	"150"	"TRUE"
"2567-5_6"	"SL003328"	"Factor I"	"Complement factor I"	"4"	"109740694"	"109802179"	"CFI"	"3426"	"P05156"	""	""	""	"Regulation of Complement cascade"	"Alternative Complement Pathway"	""	""	"Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively."	"230"	"TRUE"
"2570-72_5"	"SL000466"	"IGFBP-2"	"Insulin-like growth factor-binding protein 2"	"2"	"216632828"	"216664436"	"IGFBP2"	"3485"	"P18065"	"NA"	"NA"	"NA"	"NA"	"NA"	""	"diagnosis|efficacy|prognosis"	"Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors."	""	"TRUE"
"2571-12_3"	"SL000045"	"IGFBP-3"	"Insulin-like growth factor-binding protein 3"	"7"	"45912245"	"45921874"	"IGFBP3"	"3486"	"P17936"	"Myometrial Relaxation and Contraction Pathways"	"Direct p53 effectors|Validated transcriptional targets of TAp63 isoforms|Validated transcriptional targets of deltaNp63 isoforms"	""	"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"	""	""	"diagnosis|disease progression|efficacy|prognosis|safety"	"IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R."	"178"	"TRUE"
"2575-5_5"	"SL000498"	"Leptin"	"Leptin"	"7"	"128241284"	"128257628"	"LEP"	"3952"	"P41159"	"NA"	"NA"	"NA"	"NA"	"NA"	""	"diagnosis|efficacy|prognosis|safety|unspecified application"	"Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (PubMed:17344214, PubMed:15899045, PubMed:19688109). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity (By similarity) (PubMed:8589726, PubMed:11460888, PubMed:19688109, PubMed:24340098, PubMed:25060689). In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides (By similarity). In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption (PubMed:24340098). Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways (By similarity) (PubMed:17344214). May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression (PubMed:18242580). Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) (PubMed:11460888). In innate immunity, modulates the activity and function of neutrophils by increasing chemotaxis and the secretion of oxygen radicals. Increases phagocytosis by macrophages and enhances secretion of pro-inflammatory mediators. Increases cytotoxic ability of NK cells (PubMed:12504075). Plays a pro-inflammatory role, in synergy with IL1B, by inducing NOS2 wich promotes the production of IL6, IL8 and Prostaglandin E2, through a signaling pathway that involves JAK2, PI3K, MAP2K1/MEK1 and MAPK14/p38 (PubMed:15899045, PubMed:19688109). In adaptive immunity, promotes the switch of memory T-cells towards T helper-1 cell immune responses (By similarity). Increases CD4(+)CD25(-) T cells proliferation and reduces autophagy during TCR (T cell receptor) stimulation, through MTOR signaling pathway activation and BCL2 up-regulation (PubMed:25060689)."	""	"TRUE"
"2578-67_2"	"SL000038"	"MCP-1"	"C-C motif chemokine 2"	"17"	"34255218"	"34257203"	"CCL2"	"6347"	"P13500"	"Folate Metabolism|IL-1 signaling pathway|Selenium Pathway|TWEAK Signaling Pathway|Vitamin B12 Metabolism"	"AP-1 transcription factor network|GMCSF-mediated signaling events|IL23-mediated signaling events|Validated transcriptional targets of AP1 family members Fra1 and Fra2"	""	"ATF4 activates genes|Chemokine receptors bind chemokines"	"CCR1 -> STAT signaling|CCR2/5 -> STAT signaling|CCR5 -> TP53 signaling|MDK/PTN Expression Targets|Nociception-related CCR1 expression targets|Nociception-related IL1B expression targets|Summarized nociception-related expression targets"	"mimosine"	"diagnosis|efficacy|prognosis|response to therapy|safety|unspecified application"	"Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis."	""	"TRUE"
"2579-17_5"	"SL000527"	"MMP-9"	"Matrix metalloproteinase-9"	"20"	"46008908"	"46016561"	"MMP9"	"4318"	"P14780"	"Angiogenesis|Endochondral Ossification|Matrix Metalloproteinases|Osteopontin Signaling|TWEAK Signaling Pathway|angiogenesis overview"	"AP-1 transcription factor network|CXCR4-mediated signaling events|FGF signaling pathway|LPA receptor mediated events|Osteopontin-mediated events|Plasma membrane estrogen receptor signaling|Regulation of nuclear beta catenin signaling and target gene transcription|Syndecan-1-mediated signaling events|Syndecan-4-mediated signaling events|Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling|Validated targets of C-MYC transcriptional activation|Validated transcriptional targets of AP1 family members Fra1 and Fra2|amb2 Integrin signaling"	""	"Activation of Matrix Metalloproteinases|Assembly of collagen fibrils and other multimeric structures|Collagen degradation|Degradation of the extracellular matrix|EPH-ephrin mediated repulsion of cells|Signaling by SCF-KIT"	"Extracellular Matrix Turnover|Nociception-related CCR1 expression targets|Summarized nociception-related expression targets"	""	"diagnosis|disease progression|efficacy|prognosis|unspecified application"	"May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide."	""	"TRUE"
"2580-83_2"	"SL001796"	"Myeloperoxidase"	"Myeloperoxidase"	"17"	"58269856"	"58280935"	"MPO"	"4353"	"P05164"	"Folate Metabolism|Selenium Pathway|Vitamin B12 Metabolism"	"C-MYB transcription factor network|IL23-mediated signaling events"	""	""	"TACR1 -> TNF/IL6/IL8 production"	""	"diagnosis|efficacy|unspecified application"	"Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity."	""	"TRUE"
"2585-2_5"	"SL000546"	"PRL"	"Prolactin"	"6"	"22287244"	"22297501"	"PRL"	"5617"	"P01236"	"Prolactin Signaling Pathway|Prostaglandin Synthesis and Regulation"	"ErbB4 signaling events|Glucocorticoid receptor regulatory network|Signaling events mediated by PTP1B|Validated nuclear estrogen receptor alpha network"	""	"Amyloids|Growth hormone receptor signaling|Prolactin receptor signaling"	"GHR -> ELK-SRF/MYC signaling|GHR -> NF-kB signaling|GHR -> STAT signaling|ProlactinR -> STAT signaling"	""	"diagnosis|efficacy|safety"	"Prolactin acts primarily on the mammary gland by promoting lactation."	""	"TRUE"
"2590-69_4"	"SL006114"	"ROR1"	"Tyrosine-protein kinase transmembrane receptor ROR1"	"1"	"63774022"	"64181498"	"ROR1"	"4919"	"Q01973"	"NA"	"NA"	"NA"	"NA"	"NA"	""	""	"Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling."	""	"TRUE"
"2597-8_3"	"SL000002"	"VEGF"	"Vascular endothelial growth factor A"	"6"	"43770184"	"43786487"	"VEGFA"	"7422"	"P15692"	"Angiogenesis|Endochondral Ossification|Heart Development|Hypertrophy Model|Integrated Breast Cancer Pathway|angiogenesis overview"	"Alpha9 beta1 integrin signaling events|Beta1 integrin cell surface interactions|Beta3 integrin cell surface interactions|Glypican 1 network|HIF-1-alpha transcription factor network|HIF-2-alpha transcription factor network|Integrins in angiogenesis|Plexin-D1 Signaling|S1P1 pathway|S1P3 pathway|SHP2 signaling|Signaling events mediated by TCPTP|Signaling events mediated by VEGFR1 and VEGFR2|VEGF and VEGFR signaling network|VEGFR1 specific signals"	""	"EPHA-mediated growth cone collapse|Platelet degranulation|Regulation of gene expression by Hypoxia-inducible Factor|VEGF binds to VEGFR leading to receptor dimerization|VEGF ligand-receptor interactions|VEGFA-VEGFR2 Pathway|VEGFR2 mediated cell proliferation"	"Nociception-related CCR1 expression targets|Nociception-related IL1B expression targets|Summarized nociception-related expression targets|VEGFR -> AP-1/CREB/MYC signaling|VEGFR -> ATF/CREB/ELK-SRF signaling|VEGFR -> CTNNB signaling|VEGFR -> CTNND signaling|VEGFR -> FOXO3A signaling|VEGFR -> NFATC signaling|VEGFR -> STAT signaling"	"dalteparin|bevacizumab|ranibizumab|aflibercept|bevacizumab/erlotinib|bevacizumab/sorafenib|bevacizumab/5-fluorouracil|bevacizumab/temozolomide|bevacizumab/irinotecan|bevacizumab/carmustine/lomustine|bevacizumab/paclitaxel|bevacizumab/irinotecan/oxaliplatin|aflibercept/irinotecan|bevacizumab/capecitabine/oxaliplatin|bevacizumab/panitumumab|bevacizumab/cetuximab|bevacizumab/pemetrexed|bevacizumab/gemcitabine|bevacizumab/capecitabine/irinotecan/oxaliplatin|bevacizumab/capecitabine|bevacizumab/paclitaxel/topotecan|bevacizumab/oxaliplatin|bevacizumab/docetaxel|pegaptanib"	"diagnosis|efficacy|prognosis|safety|unspecified application"	"Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth."	""	"TRUE"
"2598-9_3"	"SL004126"	"4-1BB"	"Tumor necrosis factor receptor superfamily member 9"	"1"	"7915894"	"7943165"	"TNFRSF9"	"3604"	"Q07011"	"TCR Signaling Pathway"	"Downstream signaling in naïve CD8+ T cells"	""	""	""	"urelumab"	""	"Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation."	""	"TRUE"
"2599-51_2"	"SL003735"	"4-1BB ligand"	"Tumor necrosis factor ligand superfamily member 9"	"19"	"6530999"	"6535928"	"TNFSF9"	"8744"	"P41273"	"Leukocyte TarBase|Lymphocyte TarBase"	""	""	""	""	""	""	"Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages."	""	"TRUE"
"2602-2_2"	"SL001996"	"Angiopoietin-2"	"Angiopoietin-2"	"8"	"6499651"	"6563409"	"ANGPT2"	"285"	"O15123"	""	"Angiopoietin receptor Tie2-mediated signaling"	""	"Tie2 Signaling"	"AngiopoietinR -> AP-1 signaling|AngiopoietinR -> FOXO signaling|AngiopoietinR -> STAT signaling"	"trebananib"	"diagnosis|efficacy|prognosis|unspecified application"	"Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal."	""	"TRUE"
"2603-61_2"	"SL003738"	"B7"	"T-lymphocyte activation antigen CD80"	"3"	"119524293"	"119559602"	"CD80"	"941"	"P33681"	"Inflammatory Response Pathway|Regulation of toll-like receptor signaling pathway|Toll-like receptor signaling pathway"	"IL12 signaling mediated by STAT4|TCR signaling in naïve CD4+ T cells|TCR signaling in naïve CD8+ T cells"	""	"CD28 co-stimulation|CD28 dependent PI3K/Akt signaling|CD28 dependent Vav1 pathway|CTLA4 inhibitory signaling|Constitutive Signaling by Aberrant PI3K in Cancer|PIP3 activates AKT signaling"	"CD8+ T-cell Activation|Central T-cell Tolerance|Peripheral T-cell Tolerance Overview|Regulatory T-cell Differentiation|T-cell Receptor Signaling|T-cell receptor -> AP-1 signaling|T-cell receptor -> ATF/CREB signaling|T-cell receptor -> CREBBP signaling|T-cell receptor -> NF-kB signaling|T-cell receptor -> NFATC signaling|T-cell receptor -> STAT signaling|Th1 Cell Differentiation|Th17 Cell Differentiation|Th2 Cell Differentiation"	"abatacept|belatacept|abatacept/methotrexate"	"efficacy|prognosis"	"Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation."	""	"TRUE"
"2605-49_2"	"SL004180"	"CD30"	"Tumor necrosis factor receptor superfamily member 8"	"1"	"12063377"	"12144207"	"TNFRSF8"	"943"	"P28908"	""	""	""	""	""	"HeFi-1 monoclonal antibody|brentuximab vedotin"	"diagnosis"	"Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B."	""	"TRUE"
"2607-54_2"	"SL004692"	"CLF-1/CLC Complex"	"Cytokine receptor-like factor 1:Cardiotrophin-like cytokine factor 1 Complex"	"11|19"	"67364168|18572220"	"67374177|18607741"	"CRLF1|CLCF1"	"9244|23529"	"O75462|Q9UBD9"	""	""	""	""	"CNTFR -> STAT3 signaling"	""	""	"Cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. May be involved in nervous system development.|Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor."	""	"TRUE"
"2609-59_2"	"SL001777"	"Cystatin C"	"Cystatin-C"	"20"	"23626706"	"23638473"	"CST3"	"1471"	"P01034"	""	""	""	"Amyloids"	""	""	"diagnosis|efficacy|prognosis|safety|unspecified application"	"As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity."	"293"	"TRUE"
"2611-72_2"	"SL004136"	"Dtk"	"Tyrosine-protein kinase receptor TYRO3"	"15"	"41557675"	"41583586"	"TYRO3"	"7301"	"Q06418"	""	""	""	""	""	""	""	"Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3."	""	"TRUE"
"2612-5_2"	"SL004759"	"eIF-5"	"Eukaryotic translation initiation factor 5"	"14"	"103333544"	"103345025"	"EIF5"	"1983"	"P55010"	"Translation Factors"	""	""	"GTP hydrolysis and joining of the 60S ribosomal subunit|Ribosomal scanning and start codon recognition"	""	""	""	"Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F])."	""	"TRUE"
"2614-28_2"	"SL004140"	"Ephrin-A4"	"Ephrin-A4"	"1"	"155063731"	"155069553"	"EFNA4"	"1945"	"P52798"	""	""	""	"EPH-Ephrin signaling|EPH-ephrin mediated repulsion of cells|EPHA-mediated growth cone collapse"	"EphrinR -> STAT signaling|EphrinR -> actin signaling"	""	""	"Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils."	""	"TRUE"
"2615-60_2"	"SL004141"	"Ephrin-A5"	"Ephrin-A5"	"5"	"107376889"	"107670895"	"EFNA5"	"1946"	"P52803"	""	"EPHA forward signaling|EPHB forward signaling|Ephrin A  reverse signaling|EphrinA-EPHA pathway"	""	"EPH-Ephrin signaling|EPH-ephrin mediated repulsion of cells|EPHA-mediated growth cone collapse"	"EphrinR -> STAT signaling|EphrinR -> actin signaling"	""	""	"Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion."	""	"FALSE"
"2616-23_18"	"SL000009"	"ERBB2"	"Receptor tyrosine-protein kinase erbB-2"	"17"	"39687914"	"39730426"	"ERBB2"	"2064"	"P04626"	"DNA damage response (only ATM dependent)|EGF/EGFR Signaling Pathway|ErbB signaling pathway|Focal Adhesion|Leptin signaling pathway|Lymphocyte TarBase|Muscle cell TarBase|Prolactin Signaling Pathway"	"ErbB receptor signaling network|ErbB2/ErbB3 signaling events|ErbB4 signaling events|Validated targets of C-MYC transcriptional repression|a6b1 and a6b4 Integrin signaling"	""	"Constitutive Signaling by Aberrant PI3K in Cancer|Downregulation of ERBB2:ERBB3 signaling|GRB2 events in ERBB2 signaling|GRB7 events in ERBB2 signaling|PI3K events in ERBB2 signaling|PIP3 activates AKT signaling|PLCG1 events in ERBB2 signaling|SHC1 events in ERBB2 signaling|Sema4D induced cell migration and growth-cone collapse|Signaling by ERBB2"	"EGFR/ERBB -> STAT signaling|EGFR/ERBB2 -> CTNNB signaling|EGFR/ERBB2 -> HIF1A signaling|EGFR/ERBB2 -> TP53 signaling|ERBB2/3 -> EP300/ETS/ETV/SP1 signaling|IL6ST -> STAT5B signaling|MDK/PTN Expression Targets|Nociception-related IL6 expression targets"	"trastuzumab|BMS-599626|varlitinib|XL647|CP-724|714|afatinib|pertuzumab|sapitinib|trastuzumab emtansine|lapatinib/pazopanib|lapatinib/letrozole|paclitaxel/trastuzumab|capecitabine/lapatinib|cyclophosphamide/docetaxel/epirubicin/5-fluorouracil/trastuzumab|docetaxel/trastuzumab|paclitaxel/pertuzumab/trastuzumab|trastuzumab/vinorelbine|capecitabine/trastuzumab|lapatinib/paclitaxel|pertuzumab/trastuzumab|lapatinib/trastuzumab|neratinib|lapatinib|erlotinib"	"diagnosis|disease progression|efficacy|prognosis|safety"	"Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization."	""	"TRUE"
"2617-56_35"	"SL002519"	"ERBB3"	"Receptor tyrosine-protein kinase erbB-3"	"12"	"56079857"	"56103505"	"ERBB3"	"2065"	"P21860"	"ErbB signaling pathway|Heart Development|Muscle cell TarBase"	"ErbB receptor signaling network|ErbB2/ErbB3 signaling events|a6b1 and a6b4 Integrin signaling"	""	"Constitutive Signaling by Aberrant PI3K in Cancer|Downregulation of ERBB2:ERBB3 signaling|GRB7 events in ERBB2 signaling|PI3K events in ERBB2 signaling|PIP3 activates AKT signaling|SHC1 events in ERBB2 signaling|Signaling by ERBB2|Signaling by ERBB4"	"EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG signaling|ERBB2/3 -> EP300/ETS/ETV/SP1 signaling"	"sapitinib"	"efficacy|prognosis|safety"	"Binds and is activated by neuregulins and NTAK. May also be activated by CSPG5."	""	"TRUE"
"2618-10_2"	"SL003803"	"ERBB4"	"Receptor tyrosine-protein kinase erbB-4"	"2"	"211375717"	"212538841"	"ERBB4"	"2066"	"Q15303"	"ErbB signaling pathway"	"ErbB receptor signaling network|ErbB4 signaling events"	""	"Constitutive Signaling by Aberrant PI3K in Cancer|Downregulation of ERBB4 signaling|GRB2 events in ERBB2 signaling|Nuclear signaling by ERBB4|PI3K events in ERBB2 signaling|PI3K events in ERBB4 signaling|PIP3 activates AKT signaling|SHC1 events in ERBB2 signaling|SHC1 events in ERBB4 signaling|Signaling by ERBB2|Signaling by ERBB4"	"EGFR/ERBB -> STAT signaling"	"BMS-599626|afatinib"	"efficacy|safety"	"Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis."	""	"TRUE"
"2619-72_2"	"SL001890"	"GA733-1 protein"	"Tumor-associated calcium signal transducer 2"	"1"	"58575423"	"58577773"	"TACSTD2"	"4070"	"P09758"	""	""	""	""	""	""	""	"May function as a growth factor receptor."	""	"TRUE"
"2620-4_2"	"SL003872"	"gp130, soluble"	"Interleukin-6 receptor subunit beta"	"5"	"55935095"	"55994993"	"IL6ST"	"3572"	"P40189"	"Adipogenesis|IL-6 signaling pathway|MicroRNAs in cardiomyocyte hypertrophy|Physiological and Pathological Hypertrophy  of the Heart|Senescence and Autophagy"	"IL27-mediated signaling events|IL6-mediated signaling events|SHP2 signaling"	""	"ERK1 activation|ERK2 activation|Interleukin-6 signaling"	"CNTFR -> STAT3 signaling|IL11R -> STAT3 signaling|IL6R -> CEBP/ELK-SRF signaling|IL6R -> STAT signaling|IL6ST -> STAT5B signaling|LIFR -> STAT5A signaling|Nociception-related IL6 expression targets|OncostatinR -> STAT3 signaling|Th17 Cell Differentiation"	""	"unspecified application"	"Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Does not bind IL6 (PubMed:2261637). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity)."	"272"	"TRUE"
"2622-18_1"	"SL004751"	"HO-2"	"Heme oxygenase 2"	"16"	"4474690"	"4512305"	"HMOX2"	"3163"	"P30519"	""	""	""	"Heme degradation|Iron uptake and transport"	""	"tin mesoporphyrin"	""	"Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter."	""	"TRUE"
"2623-54_4"	"SL004697"	"HPV E7 Type 16"	"Protein E7_HPV16"	"NA"	"NA"	"NA"	"Human-virus"	"1489079"	"P03129"	""	""	""	""	""	""	""	"Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host inteferon alpha."	""	"TRUE"
"2624-31_2"	"SL004698"	"HPV E7 Type18"	"Protein E7_HPV18"	"NA"	"NA"	"NA"	"Human-virus"	"1489089"	"P06788"	""	""	""	""	""	""	""	"Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host inteferon alpha."	""	"TRUE"
"2625-53_4"	"SL017612"	"HSP 90a/b"	"Heat shock protein HSP 90-alpha/beta"	"14|6"	"102080738|44246166"	"102139699|44253888"	"HSP90AA1|HSP90AB1"	"NA"	"P07900|P08238"	""	"Signaling events mediated by VEGFR1 and VEGFR2"	""	"Attenuation phase|HSF1 activation|HSF1-dependent transactivation|Regulation of actin dynamics for phagocytic cup formation|Sema3A PAK dependent Axon repulsion|The NLRP3 inflammasome|Uptake and function of diphtheria toxin"	""	""	""	"Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.|Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function."	""	"FALSE"
"2630-12_2"	"SL004588"	"IL-1 R AcP"	"Interleukin-1 Receptor accessory protein"	"3"	"190514051"	"190659750"	"IL1RAP"	"3556"	"Q9NPH3"	"IL-1 signaling pathway"	"IL1-mediated signaling events|p73 transcription factor network"	""	"Interleukin-1 signaling"	"IL1R -> NF-kB signaling|IL1R -> STAT3 signaling|Nociception-related IL1B expression targets|Th17 Cell Differentiation"	""	""	"Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system."	"6|231|439"	"TRUE"
"2631-50_2"	"SL004147"	"IL-10 Rb"	"Interleukin-10 receptor subunit beta"	"21"	"33266358"	"33297234"	"IL10RB"	"3588"	"Q08334"	""	""	""	""	"IL10R -> STAT signaling|IL22R -> STAT3 signaling"	""	""	"Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state."	""	"TRUE"
"2632-5_2"	"SL004148"	"IL-12 Rb1"	"Interleukin-12 receptor subunit beta-1"	"19"	"18058995"	"18098944"	"IL12RB1"	"3594"	"P42701"	""	"IL12-mediated signaling events|IL23-mediated signaling events|IL27-mediated signaling events"	""	""	"CD8+ T-cell Activation|IL12R -> NF-kB/NFATC signaling|IL12R -> STAT signaling|Th1 Cell Differentiation|Th17 Cell Differentiation"	""	""	"Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade."	"55"	"TRUE"
"2633-52_2"	"SL004149"	"IL-13 Ra1"	"Interleukin-13 receptor subunit alpha-1"	"X"	"118727572"	"118794539"	"IL13RA1"	"3597"	"P78552"	""	"IL4-mediated signaling events"	""	""	"Activation of Immunoglobulin Class-Switch Recombination|IL13R -> STAT signaling|IL13R -> STAT6 signaling|Transcriptional Activation of Immunoglobulin Genes"	"cintredekin besudotox"	""	"Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity."	""	"TRUE"
"2634-2_2"	"SL003307"	"IL-2 sRg"	"Cytokine receptor common subunit gamma"	"X"	"71107404"	"71112108"	"IL2RG"	"3561"	"P31785"	"IL-2 Signaling pathway|IL-4 signaling pathway|IL-7 signaling pathway|IL-9 signaling pathway|Inflammatory Response Pathway"	"Downstream signaling in naïve CD8+ T cells|IL12-mediated signaling events|IL2 signaling events mediated by PI3K|IL2 signaling events mediated by STAT5|IL2-mediated signaling events|IL4-mediated signaling events|SHP2 signaling"	""	"G beta:gamma signalling through PI3Kgamma|GPVI-mediated activation cascade|Interleukin receptor SHC signaling|Interleukin-2 signaling|Interleukin-7 signaling"	"Activation of Immunoglobulin Class-Switch Recombination|CD8+ T-cell Activation|IL13R -> STAT6 signaling|IL15R -> NF-kB/NFATC signaling|IL15R -> STAT signaling|IL21R -> STAT signaling|IL2R -> ELK-SRF/MYC signaling|IL2R -> STAT signaling|IL4R -> ELK-SRF/HMGY signaling|IL4R -> STAT signaling|IL7R -> FOXO/NF-kB signaling|IL7R -> STAT signaling|IL9R -> STAT signaling|Model of T-cell Maturation|Natural Killer Cell Activation|Regulatory T-cell Differentiation|T-cell-Dependent B-cell Activation|Th17 Cell Differentiation|Th2 Cell Differentiation|V(D)J Recombination Activation"	"aldesleukin|denileukin diftitox"	"unspecified application"	"Common subunit for the receptors for a variety of interleukins."	""	"TRUE"
"2635-61_2"	"SL004646"	"Layilin"	"Layilin"	"11"	"111540280"	"111561745"	"LAYN"	"143903"	"Q6UX15"	""	""	""	""	""	""	""	"Receptor for hyaluronate."	""	"TRUE"
"2636-10_2"	"SL000509"	"Lymphotoxin b R"	"Tumor necrosis factor receptor superfamily member 3"	"12"	"6375045"	"6391571"	"LTBR"	"4055"	"P36941"	""	""	""	""	""	""	""	"Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs."	""	"TRUE"
"2637-77_2"	"SL004579"	"Macrophage mannose receptor"	"Macrophage mannose receptor 1"	"10"	"17809344"	"17911170"	"MRC1"	"4360"	"P22897"	""	""	""	"Cross-presentation of soluble exogenous antigens (endosomes)"	"Mannose Receptor Signaling|Transcytosis"	"technetium Tc 99m tilmanocept"	""	"Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains."	""	"TRUE"
"2638-12_2"	"SL004153"	"M-CSF R"	"Macrophage colony-stimulating factor 1 receptor"	"5"	"150053291"	"150113372"	"CSF1R"	"1436"	"P07333"	""	"C-MYB transcription factor network|Integrins in angiogenesis|Signaling events mediated by PTP1B|Signaling events mediated by TCPTP"	""	""	"CSF1R -> STAT signaling|Natural Killer Cell Activation through Integrins and non-ITAM-Containing Receptors"	"nilotinib|sunitinib|pazopanib"	"prognosis"	"Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor."	""	"TRUE"
"2640-3_2"	"SL004637"	"MSP R"	"Macrophage-stimulating protein receptor"	"3"	"49887002"	"49903873"	"MST1R"	"4486"	"Q04912"	""	"a6b1 and a6b4 Integrin signaling|amb2 Integrin signaling"	""	""	""	"crizotinib"	""	"Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand."	""	"TRUE"
"2642-4_1"	"SL004760"	"PAFAH beta subunit"	"Platelet-activating factor acetylhydrolase IB subunit beta"	"11"	"117144267"	"117176894"	"PAFAH1B2"	"5049"	"P68402"	"Lymphocyte TarBase|Muscle cell TarBase"	"Lissencephaly gene (LIS1) in neuronal migration and development"	""	""	""	""	""	"Inactivates PAF by removing the acetyl group at the sn-2 position. This is a catalytic subunit."	""	"TRUE"
"2643-57_2"	"SL004183"	"P-Cadherin"	"Cadherin-3"	"16"	"68636189"	"68722616"	"CDH3"	"1001"	"P22223"	""	""	""	"Adherens junctions interactions"	"Adherens Junction Assembly (Cadherins)"	""	"diagnosis|efficacy|prognosis"	"Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types."	""	"TRUE"
"2644-11_2"	"SL000551"	"PKC-A"	"Protein kinase C alpha type"	"17"	"66302636"	"66810743"	"PRKCA"	"5578"	"P17252"	"Alpha 6 Beta 4 signaling pathway|Calcium Regulation in the Cardiac Cell|EGF/EGFR Signaling Pathway|ErbB signaling pathway|FSH signaling pathway|G Protein Signaling Pathways|Insulin Signaling|Keap1-Nrf2 Pathway|Kit receptor signaling pathway|Myometrial Relaxation and Contraction Pathways|TOR signaling|Wnt Signaling Pathway|Wnt Signaling Pathway and Pluripotency|angiogenesis overview|miRs in Muscle Cell Differentiation"	"ATF-2 transcription factor network|Canonical NF-kappaB pathway|Downstream signaling in naïve CD8+ T cells|Endothelins|ErbB1 downstream signaling|IL8- and CXCR1-mediated signaling events|IL8- and CXCR2-mediated signaling events|PAR1-mediated thrombin signaling events|PDGFR-beta signaling pathway|Ras signaling in the CD4+ TCR pathway|Regulation of Ras family activation|Retinoic acid receptors-mediated signaling|Role of Calcineurin-dependent NFAT signaling in lymphocytes|Signaling events mediated by VEGFR1 and VEGFR2|Signaling events regulated by Ret tyrosine kinase|Syndecan-4-mediated signaling events|TCR signaling in naïve CD4+ T cells|TCR signaling in naïve CD8+ T cells|Thromboxane A2 receptor signaling|VEGFR1 specific signals|a6b1 and a6b4 Integrin signaling|mTOR signaling pathway"	""	"Acetylcholine regulates insulin secretion|Ca2+ pathway|Calmodulin induced events|Depolymerisation of the Nuclear Lamina|Disinhibition of SNARE formation|EGFR Transactivation by Gastrin|G alpha (z) signalling events|HuR stabilizes mRNA|Inactivation, recovery and regulation of the phototransduction cascade|Regulation of KIT signaling|Response to elevated platelet cytosolic Ca2+|Signaling by SCF-KIT|Syndecan interactions|Trafficking of GluR2-containing AMPA receptors|VEGFR2 mediated cell proliferation|WNT5A-dependent internalization of FZD4"	"ADORA3 -> mast cell degranulation|AdrenergicRb -> STAT3 signaling|PTGER2/3 -> inflammation-related expression targets|PTGER2/3 -> vascular motility"	"L-threo-safingol|ingenol mebutate"	""	"Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription."	""	"FALSE"
"2645-54_1"	"SL000557"	"PKC-Z"	"Protein kinase C zeta type"	"1"	"2050470"	"2185395"	"PRKCZ"	"5590"	"Q05513"	"Calcium Regulation in the Cardiac Cell|EGF/EGFR Signaling Pathway|G Protein Signaling Pathways|IL-1 signaling pathway|Insulin Signaling|MAPK signaling pathway|Myometrial Relaxation and Contraction Pathways|TNF alpha Signaling Pathway|Type II diabetes mellitus|Wnt Signaling Pathway|Wnt Signaling Pathway and Pluripotency|miRs in Muscle Cell Differentiation"	"CDC42 signaling events|CXCR4-mediated signaling events|Ceramide signaling pathway|ErbB1 downstream signaling|IGF1 pathway|IL1-mediated signaling events|IL2 signaling events mediated by PI3K|Insulin Pathway|Insulin-mediated glucose transport|Nephrin/Neph1 signaling in the kidney podocyte|Neurotrophic factor-mediated Trk receptor signaling|Noncanonical Wnt signaling pathway|Regulation of Ras family activation|RhoA signaling pathway|Role of Calcineurin-dependent NFAT signaling in lymphocytes|Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)|TNF receptor signaling pathway|Thromboxane A2 receptor signaling|amb2 Integrin signaling|p75(NTR)-mediated signaling"	""	"GPVI-mediated activation cascade|TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)|VEGFR2 mediated cell proliferation"	""	"ingenol mebutate"	""	"Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. Necessary and sufficient for LTP maintenance in hippocampal CA1 pyramidal cells. In vein endothelial cells treated with the oxidant peroxynitrite, phosphorylates STK11 leading to nuclear export of STK11, subsequent inhibition of PI3K/Akt signaling, and increased apoptosis. Phosphorylates VAMP2 in vitro (PubMed:17313651)."	""	"TRUE"
"2647-66_2"	"SL003648"	"Rab GDP dissociation inhibitor beta"	"Rab GDP dissociation inhibitor beta"	"10"	"5765223"	"5842132"	"GDI2"	"2665"	"P50395"	""	""	""	"Rho GTPase cycle"	""	""	""	"Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them."	""	"FALSE"
"2649-77_2"	"SL003178"	"sICAM-3"	"Intercellular adhesion molecule 3"	"19"	"10333776"	"10339823"	"ICAM3"	"3385"	"P32942"	""	"Beta2 integrin cell surface interactions"	""	"CD209 (DC-SIGN) signaling|Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell|Integrin cell surface interactions"	"Leukocyte Adhesion to Endothelial Cell|Natural Killer Cell Activation through Integrins and non-ITAM-Containing Receptors"	""	""	"ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2."	""	"TRUE"
"2652-15_1"	"SL002506"	"suPAR"	"Urokinase plasminogen activator surface receptor"	"19"	"43646095"	"43670547"	"PLAUR"	"5329"	"Q03405"	"Complement and Coagulation Cascades"	"Arf6 downstream pathway|Beta1 integrin cell surface interactions|Beta2 integrin cell surface interactions|Beta3 integrin cell surface interactions|Beta5 beta6 beta7 and beta8 integrin cell surface interactions|FGF signaling pathway|Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling|Validated transcriptional targets of AP1 family members Fra1 and Fra2|amb2 Integrin signaling"	""	"Attachment of GPI anchor to uPAR|Dissolution of Fibrin Clot"	"UrokinaseR -> ELK-SRF signaling|UrokinaseR -> STAT signaling"	""	"diagnosis|disease progression"	"Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form."	""	"TRUE"
"2653-62_1"	"SL004230"	"tau"	"Microtubule-associated protein tau"	"17"	"45894382"	"46039943"	"MAPT"	"4137"	"P10636"	"NA"	"NA"	"NA"	"NA"	"NA"	""	"diagnosis|efficacy|unspecified application"	"Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization."	""	"TRUE"
"2654-19_1"	"SL001992"	"TNF sR-I"	"Tumor necrosis factor receptor superfamily member 1A"	"12"	"6328757"	"6342114"	"TNFRSF1A"	"7132"	"P19438"	"Alzheimers Disease|Apoptosis|Apoptosis Modulation and Signaling|Apoptosis Modulation by HSP70|Inflammatory Response Pathway|TNF alpha Signaling Pathway"	"Canonical NF-kappaB pathway|Caspase Cascade in Apoptosis|Ceramide signaling pathway|HIV-1 Nef: Negative effector of Fas and TNF-alpha|Signaling events mediated by HDAC Class I|TNF receptor signaling pathway"	""	"TNF signaling|TNFR1-mediated proapoptotic signaling"	"Apoptosis|Cell Death Mediated by Cytotoxic Cells|Peripheral T-cell Tolerance Overview|TLR4 Signaling in Leukocytes|TNFR -> NF-kB signaling|TNFRSF1A -> AP-1/ATF/TP53 signaling|TNFRSF1A -> CREB/ELK-SRF signaling|TNFRSF1A -> STAT signaling"	""	"safety|unspecified application"	"Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase."	""	"TRUE"
"2658-27_1"	"SL004639"	"TrkC"	"NT-3 growth factor receptor"	"15"	"87859751"	"88256768"	"NTRK3"	"4916"	"Q16288"	""	"Neurotrophic factor-mediated Trk receptor signaling|SHP2 signaling"	""	""	"NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling|NTRK -> FOXO/MYCN signaling|NTRK1/2/3 -> acetylcholine production"	""	""	"Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation."	""	"FALSE"
"2665-26_2"	"SL004672"	"BCMA"	"Tumor necrosis factor receptor superfamily member 17"	"16"	"11965107"	"11968068"	"TNFRSF17"	"608"	"Q02223"	""	""	""	""	"Activation of Immunoglobulin Class-Switch Recombination|T-cell-Independent B-cell Activation"	""	""	"Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK."	""	"TRUE"
"2666-53_2"	"SL004081"	"Bone proteoglycan II"	"Decorin"	"12"	"91140484"	"91183123"	"DCN"	"1634"	"P07585"	""	"Validated transcriptional targets of AP1 family members Fra1 and Fra2"	""	"A tetrasaccharide linker sequence is required for GAG synthesis|CS/DS degradation|Chondroitin sulfate biosynthesis|Defective B3GAT3 causes JDSSDHD|Defective B4GALT7 causes EDS, progeroid type|Defective CHST14 causes EDS, musculocontractural type|Defective CHST3 causes SEDCJD|Defective CHSY1 causes TPBS|Degradation of the extracellular matrix|Dermatan sulfate biosynthesis|ECM proteoglycans"	""	""	""	"May affect the rate of fibrils formation."	""	"TRUE"
"2668-70_2"	"SL000337"	"Calpain I"	"Calpain I"	"11|19"	"65180566|36139575"	"65212006|36150353"	"CAPN1|CAPNS1"	"823|826"	"P07384|P04632"	"Alzheimers Disease|Focal Adhesion|Integrin-mediated cell adhesion"	"Signaling events mediated by PTP1B"	""	"Degradation of the extracellular matrix"	"Focal Junction Assembly"	""	""	"Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.|Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction."	"215"	"TRUE"
"2670-67_4"	"SL000383"	"CK-MM"	"Creatine kinase M-type"	"19"	"45306414"	"45322977"	"CKM"	"1158"	"P06732"	"Urea cycle and metabolism of amino groups"	"Regulation of retinoblastoma protein"	""	"Creatine metabolism"	""	""	"efficacy|safety|unspecified application"	"Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa."	""	"TRUE"
"2672-60_1"	"SL005155"	"Cripto"	"Teratocarcinoma-derived growth factor 1"	"3"	"46574555"	"46626543"	"TDGF1"	"6997"	"P13385"	"NA"	"NA"	"NA"	"NA"	"NA"	""	"diagnosis"	"Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm."	"9|347|443"	"TRUE"
"2677-1_1"	"SL002644"	"ERBB1"	"Epidermal growth factor receptor"	"7"	"55019021"	"55256620"	"EGFR"	"1956"	"P00533"	"Androgen receptor signaling pathway|EGF/EGFR Signaling Pathway|Epithelium TarBase|ErbB signaling pathway|Focal Adhesion|Integrated Breast Cancer Pathway|Lymphocyte TarBase|MAPK signaling pathway|Muscle cell TarBase|Regulation of Actin Cytoskeleton"	"Arf6 signaling events|Direct p53 effectors|E-cadherin signaling in keratinocytes|EGF receptor (ErbB1) signaling pathway|EGFR-dependent Endothelin signaling events|ErbB receptor signaling network|ErbB1 downstream signaling|Internalization of ErbB1|LPA receptor mediated events|Posttranslational regulation of adherens junction stability and dissassembly|Regulation of Telomerase|SHP2 signaling|Signaling events mediated by PTP1B|Signaling events mediated by TCPTP|Stabilization and expansion of the E-cadherin adherens junction|Syndecan-3-mediated signaling events|Thromboxane A2 receptor signaling|Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling|a6b1 and a6b4 Integrin signaling"	""	"Constitutive Signaling by Aberrant PI3K in Cancer|Constitutive Signaling by EGFRvIII|Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants|EGFR Transactivation by Gastrin|EGFR downregulation|EGFR interacts with phospholipase C-gamma|GAB1 signalosome|GRB2 events in EGFR signaling|GRB2 events in ERBB2 signaling|Inhibition of Signaling by Overexpressed EGFR|PI3K events in ERBB2 signaling|PIP3 activates AKT signaling|PLCG1 events in ERBB2 signaling|SHC1 events in EGFR signaling|SHC1 events in ERBB2 signaling|Signal transduction by L1|Signaling by EGFR|Signaling by ERBB2|Signaling by ERBB4"	"CHRM1 -> IL2 production|CholinergicRm -> CREB/ELK-SRF signaling|DRD2 -> TRPC1 transcription|DopamineR2 -> AP-1/CREB/ELK-SRF signaling|DopamineR2 -> NF-kB signaling|EDG2 -> ELK-SRF signaling|EGFR -> AP-1/ATF2 signaling|EGFR -> AP-1/CREB/ELK-SRF/MYC signaling|EGFR -> CTNND signaling|EGFR -> NCOR2 signaling|EGFR -> SMAD1 signaling|EGFR -> ZNF259 signaling|EGFR/ERBB -> STAT signaling|EGFR/ERBB2 -> CTNNB signaling|EGFR/ERBB2 -> HIF1A signaling|EGFR/ERBB2 -> TP53 signaling|EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG signaling|GRM1/5 -> CREB signaling|Gap Junction Assembly|NeurotensinR -> ELK-SRF/AP-1/EGR signaling|Nociception-related DRD2 expression targets|Nociception-related NTSR1 expression targets|ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling|ThrombinR -> NF-kB signaling|Transcytosis|VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling|VasopressinR1 -> MEF/MYOD/NFATC/MYOG signaling|VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling|VasopressinR2 -> MEF/MYOD/NFATC/MYOG signaling"	"cetuximab|AEE 788|panitumumab|BMS-599626|varlitinib|XL647|bevacizumab/erlotinib|afatinib|sapitinib|cetuximab/irinotecan|lapatinib/pazopanib|irinotecan/panitumumab|erlotinib/vismodegib|erlotinib/gemcitabine|lapatinib/letrozole|capecitabine/lapatinib|bevacizumab/panitumumab|bevacizumab/cetuximab|capecitabine/erlotinib|lapatinib/paclitaxel|cabozantinib/erlotinib|lapatinib/trastuzumab|canertinib|gefitinib|neratinib|PD 153035|lapatinib|vandetanib|erlotinib"	"diagnosis|disease progression|efficacy|prognosis|response to therapy|safety|unspecified application"	"Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin."	""	"TRUE"
"2681-23_2"	"SL000441"	"HGF"	"Hepatocyte growth factor"	"7"	"81699006"	"81770438"	"HGF"	"3082"	"P14210"	"Focal Adhesion|Signaling of Hepatocyte Growth Factor Receptor"	"Arf6 signaling events|Direct p53 effectors|FGF signaling pathway|Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)|Signaling events mediated by TCPTP|Stabilization and expansion of the E-cadherin adherens junction|Syndecan-1-mediated signaling events|Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling"	""	"Interleukin-7 signaling|Platelet degranulation"	"HGFR -> AP-1/CREB/MYC signaling|HGFR -> FOXO3A signaling|HGFR -> STAT signaling"	""	"diagnosis|disease progression|efficacy|prognosis|unspecified application"	"Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization."	""	"TRUE"
"2682-68_1"	"SL000450"	"HSP 60"	"60 kDa heat shock protein, mitochondrial"	"2"	"197486581"	"197516737"	"HSPD1"	"3329"	"P10809"	"SIDS Susceptibility Pathways"	"Endogenous TLR signaling|Validated targets of C-MYC transcriptional activation"	""	"Mitochondrial protein import"	""	""	"diagnosis|prognosis"	"Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix."	""	"TRUE"
"2683-1_2"	"SL000456"	"iC3b"	"Complement C3b, inactivated"	"19"	"6677704"	"6730562"	"C3"	"718"	"P01024"	"Complement Activation, Classical Pathway|Complement and Coagulation Cascades"	"Beta2 integrin cell surface interactions|Validated nuclear estrogen receptor alpha network|Validated nuclear estrogen receptor beta network"	""	"Activation of C3 and C5|Alternative complement activation|G alpha (i) signalling events|Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell|Peptide ligand-binding receptors|Regulation of Complement cascade"	"Alternative Complement Pathway|Classical Complement Pathway|Lectin-Induced Complement Pathway|T-cell-Independent B-cell Activation"	"IgG"	"efficacy"	"C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates."	""	"TRUE"
"2685-21_2"	"SL004676"	"IGFBP-5"	"Insulin-like growth factor-binding protein 5"	"2"	"216672105"	"216695525"	"IGFBP5"	"3488"	"P24593"	"Myometrial Relaxation and Contraction Pathways|Senescence and Autophagy"	""	""	"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"	""	""	"unspecified application"	"IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors."	""	"TRUE"
"2686-67_2"	"SL005172"	"IGFBP-6"	"Insulin-like growth factor-binding protein 6"	"12"	"53097436"	"53102345"	"IGFBP6"	"3489"	"P24592"	"Myometrial Relaxation and Contraction Pathways"	""	""	"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"	""	""	""	"IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors."	""	"TRUE"
"2687-2_1"	"SL001947"	"MIA"	"Melanoma-derived growth regulatory protein"	"19"	"40771648"	"40777490"	"MIA"	"8190"	"Q16674"	"Neural Crest Differentiation"	""	""	""	""	""	"disease progression|prognosis"	"Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas."	"139|222"	"TRUE"
"2692-74_2"	"SL002528"	"NPS-PLA2"	"Phospholipase A2, membrane associated"	"1"	"19975431"	"19980416"	"PLA2G2A"	"5320"	"P14555"	"Eicosanoid Synthesis|MicroRNAs in cardiomyocyte hypertrophy"	"Glypican 1 network"	""	"Acyl chain remodelling of PC|Acyl chain remodelling of PE|Acyl chain remodelling of PG|Acyl chain remodelling of PI|Acyl chain remodelling of PS|Synthesis of PA"	""	"varespladib methyl|varespladib|indomethacin"	"efficacy|prognosis|safety"	"Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides."	"303"	"TRUE"
"2693-20_3"	"SL000530"	"OSM"	"Oncostatin-M"	"22"	"30262829"	"30266840"	"OSM"	"5008"	"P13725"	"Adipogenesis"	"GMCSF-mediated signaling events|IL3-mediated signaling events"	""	""	"LIFR -> STAT5A signaling|OncostatinR -> STAT3 signaling"	""	"unspecified application"	"Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity)."	""	"TRUE"
"2695-25_1"	"SL001721"	"PECAM-1"	"Platelet endothelial cell adhesion molecule"	"17"	"64319415"	"64413776"	"PECAM1"	"5175"	"P16284"	""	"Beta3 integrin cell surface interactions"	""	"Cell surface interactions at the vascular wall|Integrin cell surface interactions|PECAM1 interactions|Platelet degranulation|Platelet sensitization by LDL"	"CD38 ->  NF-kB signaling|Leukocyte Adhesion to Endothelial Cell|PECAM -> CTNNB1 signaling|PECAM -> SP1 signaling|PECAM -> STAT signaling"	""	"disease progression|efficacy|prognosis"	"Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC)."	""	"TRUE"
"2696-87_2"	"SL004685"	"Persephin"	"Persephin"	"19"	"6375148"	"6379058"	"PSPN"	"5623"	"O60542"	""	""	""	"NCAM1 interactions"	""	""	""	"Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons."	""	"TRUE"
"2697-7_2"	"SL003041"	"PF-4"	"Platelet factor 4"	"4"	"73981077"	"73982124"	"PF4"	"5196"	"P02776"	""	"CXCR3-mediated signaling events"	""	"Cell surface interactions at the vascular wall|Chemokine receptors bind chemokines|Common Pathway of Fibrin Clot Formation|G alpha (i) signalling events|Platelet degranulation"	""	""	"diagnosis"	"Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form."	""	"TRUE"
"2700-56_2"	"SL000049"	"Protein S"	"Vitamin K-dependent protein S"	"3"	"93873033"	"93974066"	"PROS1"	"5627"	"P07225"	"Complement and Coagulation Cascades"	""	""	"Cell surface interactions at the vascular wall|Common Pathway of Fibrin Clot Formation|Gamma-carboxylation of protein precursors|Platelet degranulation|Regulation of Complement cascade|Removal of aminoterminal propeptides from gamma-carboxylated proteins|Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus"	"Coagulation Cascade|Vitamin K metabolism"	""	"diagnosis"	"Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis."	""	"TRUE"
"2704-74_1"	"SL004364"	"TACI"	"Tumor necrosis factor receptor superfamily member 13B"	"17"	"16929816"	"16972118"	"TNFRSF13B"	"23495"	"O14836"	""	"Syndecan-2-mediated signaling events|Syndecan-4-mediated signaling events"	""	""	"Activation of Immunoglobulin Class-Switch Recombination|T-cell-Independent B-cell Activation|TNFR -> AP-1/ATF/TP53 signaling|TNFR -> CREB/ELK-SRF signaling|TNFR -> NF-kB signaling|TNFRSF5/13B -> NFATC1 signaling"	""	"diagnosis"	"Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity."	""	"TRUE"
"2705-5_2"	"SL003197"	"TECK"	"C-C motif chemokine 25"	"19"	"8052767"	"8062650"	"CCL25"	"6370"	"O15444"	""	""	""	"Chemokine receptors bind chemokines|G alpha (i) signalling events"	""	""	"disease progression"	"Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4."	"189|278"	"TRUE"
"2706-69_2"	"SL000590"	"Thyroxine-Binding Globulin"	"Thyroxine-Binding Globulin"	"X"	"106032442"	"106038738"	"SERPINA7"	"6906"	"P05543"	""	""	""	""	""	""	""	"Major thyroid hormone transport protein in serum."	""	"TRUE"
"2708-54_2"	"SL004326"	"TNFSF18"	"Tumor necrosis factor ligand superfamily member 18"	"1"	"173039960"	"173050963"	"TNFSF18"	"8995"	"Q9UNG2"	""	""	""	""	""	""	""	"Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity)."	""	"TRUE"
"2711-6_2"	"SL005153"	"CNTFR alpha"	"Ciliary neurotrophic factor receptor subunit alpha"	"9"	"34551432"	"34590140"	"CNTFR"	"1271"	"P26992"	"Adipogenesis"	""	""	""	"CNTFR -> STAT3 signaling"	""	""	"Binds to CNTF. The alpha subunit provides the receptor specificity."	""	"TRUE"
"2714-78_2"	"SL003334"	"EMAP-2"	"Endothelial monocyte-activating polypeptide 2"	"4"	"106315544"	"106349226"	"AIMP1"	"9255"	"Q12904"	""	""	""	"Cytosolic tRNA aminoacylation"	""	""	"diagnosis"	"Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7."	""	"TRUE"
"2715-25_2"	"SL005159"	"EPO-R"	"Erythropoietin receptor"	"19"	"11377205"	"11384342"	"EPOR"	"2057"	"P19235"	"EPO Receptor Signaling"	"EPO signaling pathway|Signaling events mediated by Stem cell factor receptor (c-Kit)"	""	""	"ErythropoietinR -> AP-1/CREB/MYC signaling|ErythropoietinR -> ELK-SRF/FOS signaling|ErythropoietinR -> FOXO3A signaling|ErythropoietinR -> NF-kB signaling|ErythropoietinR -> STAT signaling"	"darbepoetin alfa|continuous erythropoietin receptor activator|peginesatide|EPO|EPO/sargramostim|darbepoetin alfa/filgrastim|EPO/filgrastim|erythropoietin/lenalidomide"	""	"Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase."	""	"TRUE"
"2719-3_4"	"SL004591"	"G-CSF-R"	"Granulocyte colony-stimulating factor receptor"	"1"	"36466043"	"36483278"	"CSF3R"	"1441"	"Q99062"	""	""	""	""	"CSF3R -> STAT signaling"	"cladribine/cytarabine/filgrastim|cytarabine/filgrastim/fludarabine phosphate|cladribine/cytarabine/filgrastim/mitoxantrone|clofarabine/cytarabine/filgrastim|cytarabine/filgrastim/fludarabine phosphate/idarubicin|cladribine/cytarabine/filgrastim/idarubicin|darbepoetin alfa/filgrastim|EPO/filgrastim|cladribine/cytarabine/filgrastim/idarubicin/plerixafor|clofarabine/filgrastim/idarubicin|clofarabine/cytarabine/filgrastim/idarubicin|clofarabine/filgrastim|pegfilgrastim|filgrastim"	""	"Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface."	""	"TRUE"
"2723-9_2"	"SL005178"	"IL-1F7"	"Interleukin-37"	"2"	"112912971"	"112918882"	"IL37"	"27178"	"Q9NZH6"	""	""	""	""	""	""	""	"Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation."	""	"TRUE"
"2728-62_2"	"SL000497"	"Laminin"	"Laminin"	"1|18|7"	"183023460|6941744|107923799"	"183145592|7117814|108003255"	"LAMA1|LAMB1|LAMC1"	"284217|3912|3915"	"P25391|P07942|P11047"	"Alpha 6 Beta 4 signaling pathway|Focal Adhesion"	"Alpha6 beta4 integrin-ligand interactions|Beta1 integrin cell surface interactions|Glypican 1 network|Syndecan-2-mediated signaling events|Syndecan-4-mediated signaling events|a6b1 and a6b4 Integrin signaling"	""	"ECM proteoglycans|L1CAM interactions|Laminin interactions|Non-integrin membrane-ECM interactions"	""	""	""	"Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.|Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface.|Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components."	""	"TRUE"
"2730-58_2"	"SL005199"	"MICA"	"MHC class I polypeptide-related sequence A"	"6"	"31389818"	"31459233"	"MICA"	"4276"	"Q29983"	""	""	""	""	"Natural Killer Cell Activation|Natural Killer Cell Activation through C-type Lectin-like Receptors"	""	"safety"	"Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis."	"13|149|167|170|175|179|199|205|236|245|263|271|283|285|338|342|407|423"	"TRUE"
"2731-29_2"	"SL000528"	"NADPH-P450 Oxidoreductase"	"NADPH--cytochrome P450 reductase"	"7"	"75899200"	"75986855"	"POR"	"5447"	"P16435"	"cytochrome P450"	""	""	""	""	"daunorubicin/tretinoin|cisplatin/doxorubicin/methotrexate|cisplatin/doxorubicin/ifosfamide/methotrexate|cisplatin/doxorubicin|carboplatin/doxorubicin|dacarbazine/doxorubicin|doxorubicin/ifosfamide|doxorubicin/streptozocin|dacarbazine/doxorubicin/ifosfamide|doxorubicin/tretinoin|nitazoxanide/peginterferon alfa-2a/ribavirin|nitazoxanide|doxorubicin|daunorubicin"	""	"This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5."	""	"TRUE"
"2732-58_3"	"SL005235"	"NANOG"	"Homeobox protein NANOG"	"12"	"7787794"	"7799141"	"NANOG"	"79923"	"Q9H9S0"	"Wnt Signaling Pathway and Pluripotency"	""	""	"POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation|POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation|Transcriptional regulation of pluripotent stem cells"	""	""	"diagnosis"	"Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation."	""	"TRUE"
"2734-49_4"	"SL005206"	"NKp44"	"Natural cytotoxicity triggering receptor 2"	"6"	"41335655"	"41350887"	"NCR2"	"9436"	"O95944"	""	""	""	"DAP12 interactions"	"Natural Killer Cell Activation through ITAM-Containing Receptors"	""	""	"Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis."	""	"TRUE"
"2737-22_2"	"SL005236"	"NovH"	"Protein NOV homolog"	"8"	"119416306"	"119424353"	"NOV"	"4856"	"P48745"	""	""	""	""	""	""	""	"Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival (PubMed:15181016, PubMed:15611078, PubMed:12695522, PubMed:21344378, PubMed:12050162). Acts by binding to integrins or membrane receptors such as NOTCH1 (PubMed:12695522, PubMed:21344378, PubMed:15611078). Essential regulator of hematopoietic stem and progenitor cell function (PubMed:17463287). Inhibits myogenic differentiation through the activation of Notch-signaling pathway (PubMed:12050162). Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling (PubMed:20139355). Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival (PubMed:12695522). Plays also a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts (PubMed:15611078). Involved in bone regeneration as a negative regulator (By similarity). Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification (PubMed:21871891). Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion (By similarity). Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway (PubMed:21063504). Contributes to the control and coordination of inflammatory processes in atherosclerosis (By similarity). Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement (PubMed:21871891)."	""	"TRUE"
"2741-22_2"	"SL005217"	"Siglec-6"	"Sialic acid-binding Ig-like lectin 6"	"19"	"51519525"	"51531856"	"SIGLEC6"	"946"	"O43699"	""	""	""	""	""	""	""	"Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface."	"84|136|428"	"TRUE"
"2742-68_2"	"SL005218"	"Siglec-7"	"Sialic acid-binding Ig-like lectin 7"	"19"	"51142299"	"51153526"	"SIGLEC7"	"27036"	"Q9Y286"	""	""	""	""	"Natural Killer Cell Inhibitory Receptor Signaling"	""	""	"Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro)."	""	"TRUE"
"2743-5_2"	"SL005220"	"Sonic Hedgehog"	"Sonic hedgehog protein"	"7"	"155799986"	"155812273"	"SHH"	"6469"	"Q15465"	"Heart Development|Hedgehog Signaling Pathway|Proteins and DNA Sequences in Cardicac Structures|TWEAK Signaling Pathway"	"FOXA1 transcription factor network|Glypican 3 network|Hedgehog signaling events mediated by Gli proteins|Signaling events mediated by the Hedgehog family|Validated transcriptional targets of TAp63 isoforms"	""	"Class B/2 (Secretin family receptors)|Hedgehog ligand biogenesis|Hh mutants that don't undergo autocatalytic processing are degraded by ERAD|Ligand-receptor interactions|Release of Hh-Np from the secreting cell"	""	""	"diagnosis|efficacy|response to therapy|unspecified application"	"Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Activates the transcription of target genes by interacting with its receptor PTCH1 to prevent normal inhibition by PTCH1 on the constitutive signaling activity of SMO (By similarity)."	""	"TRUE"
"2746-56_1"	"SL005226"	"TSLP R"	"Cytokine receptor-like factor 2"	"X"	"1187549"	"1212750"	"CRLF2"	"64109"	"Q9HC73"	""	""	""	""	""	""	""	"Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system."	""	"TRUE"
"2747-3_2"	"SL005229"	"ULBP-3"	"NKG2D ligand 3"	"6"	"150063150"	"150069095"	"ULBP3"	"79465"	"Q9BZM4"	""	""	""	"Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"	"Natural Killer Cell Activation"	""	""	"Ligand for the KLRK1/NKG2D receptor, together with at least ULBP1 and ULBP2. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. Has lower affinity for KLRK1/NKG2D compared to ULBP1 and ULBP2 and induces weaker signaling responses than does ULBP2 or ULBP1."	""	"TRUE"
"2748-3_2"	"SL001938"	"Activin A"	"Inhibin beta A chain"	"7"	"41685114"	"41703108"	"INHBA"	"3624"	"P08476"	"Senescence and Autophagy|TGF Beta Signaling Pathway"	"ALK1 signaling events"	""	"Antagonism of Activin by Follistatin|Glycoprotein hormones|Signaling by Activin"	"ActivinR -> SMAD2/3 signaling|ActivinR/BMPR -> SMAD1/5/9 signaling"	""	"diagnosis"	"Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins."	""	"TRUE"
"2751-16_2"	"SL004589"	"Azurocidin"	"Azurocidin"	"19"	"825097"	"832018"	"AZU1"	"566"	"P20160"	""	""	""	""	""	""	""	"This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G."	""	"TRUE"
"2752-62_2"	"SL004329"	"BMP-14"	"Growth/differentiation factor 5"	"20"	"35433347"	"35454746"	"GDF5"	"8200"	"P43026"	""	""	""	"Molecules associated with elastic fibres"	"ActivinR -> SMAD2/3 signaling|ActivinR/BMPR -> SMAD1/5/9 signaling"	""	""	"Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (PubMed:24098149, PubMed:21976273, PubMed:15530414, PubMed:25092592). Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG (PubMed:21976273). Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (By similarity). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205)."	""	"TRUE"
"2753-2_2"	"SL000309"	"C1q"	"Complement C1q subcomponent"	"1"	"22636506"	"22661538"	"C1QA|C1QB|C1QC"	"712|713|714"	"P02745|P02746|P02747"	"Complement Activation, Classical Pathway|Complement and Coagulation Cascades"	""	""	"Classical antibody-mediated complement activation|Initial triggering of complement"	""	""	""	"C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.|C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.|C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes."	"115"	"TRUE"
"2754-50_2"	"SL000312"	"C3"	"Complement C3"	"19"	"6677704"	"6730562"	"C3"	"718"	"P01024"	"Complement Activation, Classical Pathway|Complement and Coagulation Cascades"	"Beta2 integrin cell surface interactions|Validated nuclear estrogen receptor alpha network|Validated nuclear estrogen receptor beta network"	""	"Activation of C3 and C5|Alternative complement activation|G alpha (i) signalling events|Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell|Peptide ligand-binding receptors|Regulation of Complement cascade"	"Alternative Complement Pathway|Classical Complement Pathway|Lectin-Induced Complement Pathway|T-cell-Independent B-cell Activation"	"IgG"	"efficacy"	"C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates."	""	"TRUE"
"2755-8_2"	"SL003220"	"C3adesArg"	"C3a anaphylatoxin des Arginine"	"19"	"6677704"	"6730562"	"C3"	"718"	"P01024"	"Complement Activation, Classical Pathway|Complement and Coagulation Cascades"	"Beta2 integrin cell surface interactions|Validated nuclear estrogen receptor alpha network|Validated nuclear estrogen receptor beta network"	""	"Activation of C3 and C5|Alternative complement activation|G alpha (i) signalling events|Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell|Peptide ligand-binding receptors|Regulation of Complement cascade"	"Alternative Complement Pathway|Classical Complement Pathway|Lectin-Induced Complement Pathway|T-cell-Independent B-cell Activation"	"IgG"	"efficacy"	"C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates."	""	"TRUE"
"2760-2_2"	"SL004752"	"DRR1"	"Protein FAM107A"	"3"	"58564117"	"58627610"	"FAM107A"	"11170"	"O95990"	""	""	""	""	""	""	""	"When transfected into cell lines in which it is not expressed, suppresses cell growth. May play a role in tumor development."	""	"TRUE"
"2761-49_2"	"SL004336"	"FGF-18"	"Fibroblast growth factor 18"	"5"	"171419656"	"171457623"	"FGF18"	"8817"	"O76093"	"Endochondral Ossification|Regulation of Actin Cytoskeleton"	"FGF signaling pathway"	""	"Activated point mutants of FGFR2|Constitutive Signaling by Aberrant PI3K in Cancer|FGFR2c ligand binding and activation|FGFR3 mutant receptor activation|FGFR3b ligand binding and activation|FGFR3c ligand binding and activation|FGFR4 ligand binding and activation|FRS-mediated FGFR2 signaling|FRS-mediated FGFR3 signaling|FRS2-mediated FGFR4 signaling|Negative regulation of FGFR2 signaling|Negative regulation of FGFR3 signaling|Negative regulation of FGFR4 signaling|PI-3K cascade:FGFR2|PI-3K cascade:FGFR3|PI-3K cascade:FGFR4|PI3K Cascade|PIP3 activates AKT signaling|Phospholipase C-mediated cascade, FGFR2|Phospholipase C-mediated cascade, FGFR3|Phospholipase C-mediated cascade, FGFR4|SHC-mediated cascade:FGFR2|SHC-mediated cascade:FGFR3|SHC-mediated cascade:FGFR4|Signaling by FGFR2 mutants|Signaling by FGFR3 mutants|Signaling by FGFR4 mutants|Signaling by activated point mutants of FGFR3"	"FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling|FGFR -> RUNX2 signaling|FGFR3 -> STAT signaling"	""	""	"Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation."	""	"TRUE"
"2762-30_2"	"SL004337"	"FGF-19"	"Fibroblast growth factor 19"	"11"	"69698232"	"69704642"	"FGF19"	"9965"	"O95750"	"Neural Crest Differentiation"	"FGF signaling pathway"	""	"Constitutive Signaling by Aberrant PI3K in Cancer|FGFR4 ligand binding and activation|FRS2-mediated FGFR4 signaling|Negative regulation of FGFR4 signaling|PI-3K cascade:FGFR4|PI3K Cascade|PIP3 activates AKT signaling|Phospholipase C-mediated cascade, FGFR4|SHC-mediated cascade:FGFR4|betaKlotho-mediated ligand binding"	""	""	""	"Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4."	""	"TRUE"
"2763-66_2"	"SL004338"	"FGF-20"	"Fibroblast growth factor 20"	"8"	"16992169"	"17002181"	"FGF20"	"26281"	"Q9NP95"	"Regulation of Actin Cytoskeleton"	""	""	"Activated point mutants of FGFR2|Constitutive Signaling by Aberrant PI3K in Cancer|FGFR1c ligand binding and activation|FGFR2c ligand binding and activation|FGFR3 mutant receptor activation|FGFR3b ligand binding and activation|FGFR3c ligand binding and activation|FGFR4 ligand binding and activation|FRS-mediated FGFR1 signaling|FRS-mediated FGFR2 signaling|FRS-mediated FGFR3 signaling|FRS2-mediated FGFR4 signaling|Negative regulation of FGFR1 signaling|Negative regulation of FGFR2 signaling|Negative regulation of FGFR3 signaling|Negative regulation of FGFR4 signaling|PI-3K cascade:FGFR1|PI-3K cascade:FGFR2|PI-3K cascade:FGFR3|PI-3K cascade:FGFR4|PI3K Cascade|PIP3 activates AKT signaling|Phospholipase C-mediated cascade, FGFR2|Phospholipase C-mediated cascade, FGFR3|Phospholipase C-mediated cascade, FGFR4|Phospholipase C-mediated cascade: FGFR1|SHC-mediated cascade:FGFR1|SHC-mediated cascade:FGFR2|SHC-mediated cascade:FGFR3|SHC-mediated cascade:FGFR4|Signaling by FGFR1 mutants|Signaling by FGFR2 mutants|Signaling by FGFR3 mutants|Signaling by FGFR4 mutants|Signaling by activated point mutants of FGFR1|Signaling by activated point mutants of FGFR3"	""	""	""	"Neurotrophic factor that regulates central nervous development and function."	""	"TRUE"
"2764-20_2"	"SL003849"	"FGF9"	"Fibroblast growth factor 9"	"13"	"21671383"	"21704498"	"FGF9"	"2254"	"P31371"	"Regulation of Actin Cytoskeleton"	"FGF signaling pathway"	""	"Activated point mutants of FGFR2|Constitutive Signaling by Aberrant PI3K in Cancer|FGFR1c ligand binding and activation|FGFR2c ligand binding and activation|FGFR3 mutant receptor activation|FGFR3b ligand binding and activation|FGFR3c ligand binding and activation|FGFR4 ligand binding and activation|FRS-mediated FGFR1 signaling|FRS-mediated FGFR2 signaling|FRS-mediated FGFR3 signaling|FRS2-mediated FGFR4 signaling|Negative regulation of FGFR1 signaling|Negative regulation of FGFR2 signaling|Negative regulation of FGFR3 signaling|Negative regulation of FGFR4 signaling|PI-3K cascade:FGFR1|PI-3K cascade:FGFR2|PI-3K cascade:FGFR3|PI-3K cascade:FGFR4|PI3K Cascade|PIP3 activates AKT signaling|Phospholipase C-mediated cascade, FGFR2|Phospholipase C-mediated cascade, FGFR3|Phospholipase C-mediated cascade, FGFR4|Phospholipase C-mediated cascade: FGFR1|SHC-mediated cascade:FGFR1|SHC-mediated cascade:FGFR2|SHC-mediated cascade:FGFR3|SHC-mediated cascade:FGFR4|Signaling by FGFR1 mutants|Signaling by FGFR2 mutants|Signaling by FGFR3 mutants|Signaling by FGFR4 mutants|Signaling by activated point mutants of FGFR1|Signaling by activated point mutants of FGFR3"	"FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling|FGFR -> RUNX2 signaling|FGFR3 -> STAT signaling"	""	"unspecified application"	"Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors."	""	"TRUE"
"2765-4_3"	"SL004345"	"GDF-11"	"Growth/differentiation factor 11"	"12"	"55743280"	"55757278"	"GDF11"	"10220"	"O95390"	""	""	""	""	"ActivinR -> SMAD2/3 signaling|ActivinR/BMPR -> SMAD1/5/9 signaling"	""	""	"Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern."	""	"TRUE"
"2768-56_2"	"SL000440"	"Hemopexin"	"Hemopexin"	"11"	"6431049"	"6442617"	"HPX"	"3263"	"P02790"	""	""	""	"Scavenging of heme from plasma"	""	""	""	"Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation."	"72|76|112|173|250"	"TRUE"
"2769-3_2"	"SL000445"	"HIV-2 Rev"	"Protein Rev_HV2BE"	"NA"	"NA"	"NA"	"Human-virus"	"1724716"	"P18093"	""	""	""	""	""	""	""	"Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells. These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts). This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs (By similarity)."	""	"TRUE"
"2770-51_2"	"SL003176"	"I-309"	"C-C motif chemokine 1"	"17"	"34360328"	"34363231"	"CCL1"	"6346"	"P22362"	""	""	""	""	""	""	""	"Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8."	"210"	"TRUE"
"2771-35_2"	"SL000462"	"IGFBP-1"	"Insulin-like growth factor-binding protein 1"	"7"	"45888357"	"45893668"	"IGFBP1"	"3484"	"P08833"	"Myometrial Relaxation and Contraction Pathways"	"FOXA2 and FOXA3 transcription factor networks|HIF-1-alpha transcription factor network"	""	"ATF4 activates genes|Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"	""	""	"diagnosis|efficacy"	"IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration."	""	"TRUE"
"2773-50_2"	"SL001717"	"IL-10"	"Interleukin-10"	"1"	"206767602"	"206772494"	"IL10"	"3586"	"P22301"	"Cytokines and Inflammatory Response|SIDS Susceptibility Pathways|Th1/Th2"	"AP-1 transcription factor network|IL4-mediated signaling events|Regulation of nuclear SMAD2/3 signaling"	""	""	"BDKRB1/2 -> interleukins production|CNR1/2 -> IL1B/2/4/6/10 production|DC-SIGN (CD209) Signaling|Dectin-1 (CLEC7A) Signaling|HRH2/4 -> IL6/10 production|IL10R -> STAT signaling|Leptin -> CD25/IL6/IL10 production|Nociception-related CCR1 expression targets|P2RY11/13/14 -> IL8/10 production|Regulatory T-cell Differentiation|Summarized nociception-related expression targets|TLR4 Signaling in Leukocytes|Th2 Cell Differentiation"	""	"diagnosis|disease progression|efficacy|prognosis|response to therapy|safety|unspecified application"	"Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells."	""	"TRUE"
"2774-10_3"	"SL000474"	"IL-16"	"Interleukin-16"	"15"	"81159575"	"81314058"	"IL16"	"3603"	"Q14005"	""	""	""	""	"HRH2/4 -> IL6/10 production|Summarized nociception-related expression targets|T-cell receptor -> AP-1 signaling|T-cell receptor -> ATF/CREB signaling|T-cell receptor -> CREBBP signaling|T-cell receptor -> NF-kB signaling|T-cell receptor -> NFATC signaling|T-cell receptor -> STAT signaling"	""	""	"Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4."	"418"	"TRUE"
"2775-54_2"	"SL004352"	"IL-17F"	"Interleukin-17F"	"6"	"52236681"	"52244537"	"IL17F"	"112744"	"Q96PD4"	""	"IL23-mediated signaling events"	""	""	"Th17 Cell Differentiation"	""	""	"Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover (PubMed:11591732, PubMed:11591768, PubMed:11574464). Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis (PubMed:11591732). Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation (By similarity)."	""	"TRUE"
"2778-10_2"	"SL004347"	"IL-22"	"Interleukin-22"	"12"	"68248242"	"68253607"	"IL22"	"50616"	"Q9GZX6"	""	""	""	""	"IL22R -> STAT3 signaling|Th17 Cell Differentiation"	""	""	"Cytokine that contributes to the inflammatory response in vivo."	""	"TRUE"
"2780-35_2"	"SL000496"	"Lactoferrin"	"Lactotransferrin"	"3"	"46435645"	"46485234"	"LTF"	"4057"	"P02788"	""	""	""	"Amyloids|Mtb iron assimilation by chelation|Phagosomal maturation (early endosomal stage)"	""	""	"efficacy|unspecified application"	"Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate."	""	"TRUE"
"2781-63_2"	"SL004356"	"LAG-1"	"C-C motif chemokine 4-like"	"17"	"36210924"	"36314484"	"CCL4L1"	"388372"	"Q8NHW4"	""	""	""	""	""	""	""	"Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5."	"284|427"	"TRUE"
"2783-18_2"	"SL004355"	"LD78-beta"	"C-C motif chemokine 3-like 1"	"17"	"36194869"	"36298368"	"CCL3L1"	"414062"	"P16619"	""	""	""	"Chemokine receptors bind chemokines"	""	""	""	"Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5."	"369"	"TRUE"
"2785-15_2"	"SL000515"	"MCP-2"	"C-C motif chemokine 8"	"17"	"34319036"	"34321402"	"CCL8"	"6355"	"P80075"	""	""	""	""	"CCR1 -> STAT signaling|CCR2/5 -> STAT signaling|CCR5 -> TP53 signaling|Nociception-related CCR1 expression targets|Summarized nociception-related expression targets"	""	"unspecified application"	"Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8."	"53"	"TRUE"
"2788-55_1"	"SL000524"	"MMP-3"	"Stromelysin-1"	"11"	"102835801"	"102843803"	"MMP3"	"4314"	"P08254"	"Matrix Metalloproteinases"	"Posttranslational regulation of adherens junction stability and dissassembly|Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling|p75(NTR)-mediated signaling"	""	"Activation of Matrix Metalloproteinases|Assembly of collagen fibrils and other multimeric structures|Collagen degradation|Degradation of the extracellular matrix|EGFR Transactivation by Gastrin"	""	"marimastat"	"diagnosis|efficacy"	"Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase."	""	"TRUE"
"2789-26_2"	"SL000525"	"MMP-7"	"Matrilysin"	"11"	"102520508"	"102530753"	"MMP7"	"4316"	"P09237"	"Matrix Metalloproteinases|Wnt Signaling Pathway and Pluripotency"	"Posttranslational regulation of adherens junction stability and dissassembly|Syndecan-1-mediated signaling events|p75(NTR)-mediated signaling"	""	"Activation of Matrix Metalloproteinases|Assembly of collagen fibrils and other multimeric structures|Collagen degradation|Degradation of the extracellular matrix"	""	"marimastat"	"diagnosis"	"Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase."	"316"	"TRUE"
"2790-54_2"	"SL003191"	"NAP-2"	"Neutrophil-activating peptide 2"	"4"	"73987038"	"73988197"	"PPBP"	"5473"	"P02775"	""	""	""	"Chemokine receptors bind chemokines|G alpha (i) signalling events|Platelet degranulation"	""	""	""	"LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation."	""	"TRUE"
"2794-60_2"	"SL000581"	"SOD"	"Superoxide dismutase [Cu-Zn]"	"21"	"31659622"	"31668931"	"SOD1"	"6647"	"P00441"	"Folate Metabolism|Oxidative Stress|Selenium Pathway|Vitamin B12 Metabolism"	"FOXA1 transcription factor network|Validated nuclear estrogen receptor alpha network"	""	"Detoxification of Reactive Oxygen Species|Platelet degranulation"	""	""	"unspecified application"	"Destroys radicals which are normally produced within the cells and which are toxic to biological systems."	""	"TRUE"
"2795-23_3"	"SL002077"	"Alkaline phosphatase, bone"	"Alkaline phosphatase, tissue-nonspecific isozyme"	"1"	"21509372"	"21578412"	"ALPL"	"249"	"P05186"	"Endochondral Ossification"	""	""	""	""	""	"efficacy|safety"	"This isozyme may play a role in skeletal mineralization."	"157"	"TRUE"
"2796-62_2"	"SL000424"	"Fibrinogen"	"Fibrinogen"	"4"	"154562956"	"154612967"	"FGA|FGB|FGG"	"2243|2244|2266"	"P02671|P02675|P02679"	"Blood Clotting Cascade"	"Beta1 integrin cell surface interactions|Beta2 integrin cell surface interactions|Beta3 integrin cell surface interactions|Ephrin B reverse signaling|Glucocorticoid receptor regulatory network|IL6-mediated signaling events|Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling"	""	"Common Pathway of Fibrin Clot Formation|GRB2:SOS provides linkage to MAPK signaling for Integrins|Integrin alphaIIb beta3 signaling|Integrin cell surface interactions|Platelet degranulation|p130Cas linkage to MAPK signaling for integrins"	""	"F2"	""	"Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.|Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.|Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways."	""	"TRUE"
"2797-56_2"	"SL000020"	"Apo B"	"Apolipoprotein B"	"2"	"21001429"	"21044073"	"APOB"	"338"	"P04114"	"Folate Metabolism|Selenium Pathway|Statin Pathway|Vitamin B12 Metabolism"	"FOXA1 transcription factor network|amb2 Integrin signaling"	""	"Cell surface interactions at the vascular wall|Chylomicron-mediated lipid transport|LDL-mediated lipid transport|Platelet sensitization by LDL|Retinoid metabolism and transport|Scavenging by Class A Receptors|Scavenging by Class B Receptors|Scavenging by Class F Receptors|Scavenging by Class H Receptors"	""	"mipomersen"	"diagnosis|efficacy"	"Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor."	"357"	"TRUE"
"2805-6_2"	"SL004415"	"ACE2"	"Angiotensin-converting enzyme 2"	"X"	"15561033"	"15602148"	"ACE2"	"59272"	"Q9BYF1"	"ACE Inhibitor Pathway"	""	""	"Metabolism of Angiotensinogen to Angiotensins"	""	"hydrochlorothiazide/lisinopril|hydrochlorothiazide/moexipril|moexipril|lisinopril"	""	"Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function."	""	"TRUE"
"2806-49_2"	"SL004128"	"Activin RIB"	"Activin receptor type-1B"	"12"	"51951667"	"51997078"	"ACVR1B"	"91"	"P36896"	"MAPK signaling pathway|Muscle cell TarBase"	""	""	"Regulation of signaling by NODAL|Signaling by Activin|Signaling by NODAL"	"ActivinR -> SMAD2/3 signaling"	""	""	"Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2."	""	"TRUE"
"2809-25_2"	"SL004625"	"ADAMTS-4"	"A disintegrin and metalloproteinase with thrombospondin motifs 4"	"1"	"161184308"	"161199056"	"ADAMTS4"	"9507"	"O75173"	"Endochondral Ossification"	""	""	"Degradation of the extracellular matrix|O-glycosylation of TSR domain-containing proteins"	""	""	""	"Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site."	""	"TRUE"
"2811-27_1"	"SL001995"	"Angiopoietin-1"	"Angiopoietin-1"	"8"	"107249482"	"107498055"	"ANGPT1"	"284"	"Q15389"	"Angiogenesis|angiogenesis overview"	"Angiopoietin receptor Tie2-mediated signaling|SHP2 signaling"	""	"Tie2 Signaling"	"AngiopoietinR -> AP-1 signaling|AngiopoietinR -> FOXO signaling|AngiopoietinR -> STAT signaling"	"trebananib"	"disease progression|efficacy|prognosis"	"Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme."	""	"TRUE"
"2813-11_2"	"SL006924"	"ART"	"Agouti-related protein"	"16"	"67482571"	"67483813"	"AGRP"	"181"	"O00253"	""	"Syndecan-3-mediated signaling events"	""	""	""	""	"unspecified application"	"Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner."	"227|446"	"TRUE"
"2816-50_2"	"SL001902"	"BCAM"	"Basal Cell Adhesion Molecule"	"19"	"44809059"	"44821420"	"BCAM"	"4059"	"P50895"	""	""	""	""	""	""	"diagnosis"	"Laminin alpha-5 receptor. May mediate intracellular signaling."	"69"	"TRUE"
"2819-23_2"	"SL002081"	"Cadherin-5"	"Cadherin-5"	"16"	"66366622"	"66404786"	"CDH5"	"1003"	"P33151"	""	"S1P2 pathway|Signaling events mediated by VEGFR1 and VEGFR2"	""	"Adherens junctions interactions|VEGFR2 mediated vascular permeability"	"Leukocyte Adhesion to Endothelial Cell"	""	"diagnosis"	"Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction."	"28|69"	"TRUE"
"2822-56_2"	"SL004726"	"CD97"	"CD97 antigen"	"19"	"14380501"	"14408725"	"CD97"	"976"	"P48960"	"GPCRs, Class B Secretin-like"	""	""	"Class B/2 (Secretin family receptors)"	""	""	""	"Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration (By similarity)."	""	"TRUE"
"2823-7_1"	"SL004704"	"COMMD7"	"COMM domain-containing protein 7"	"20"	"32702691"	"32743997"	"COMMD7"	"149951"	"Q86VX2"	""	""	""	""	""	""	""	"May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Associates with the NF-kappa-B complex and suppresses its transcriptional activity (PubMed:15799966)."	""	"TRUE"
"2826-53_2"	"SL004644"	"EDA"	"Ectodysplasin-A, secreted form"	"X"	"69616067"	"70039469"	"EDA"	"1896"	"Q92838"	""	""	""	""	"EctodysplasinR -> AP-1 signaling|EctodysplasinR -> LEF1 signaling|EctodysplasinR -> NF-kB signaling"	""	""	"Seems to be involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Isoform 1 binds only to the receptor EDAR, while isoform 3 binds exclusively to the receptor XEDAR."	""	"TRUE"
"2827-23_2"	"SL000427"	"Fractalkine/CX3CL-1"	"Fractalkine"	"16"	"57372458"	"57385048"	"CX3CL1"	"6376"	"P78423"	""	"Direct p53 effectors"	""	"Chemokine receptors bind chemokines"	"Nociception-related IL1B expression targets"	""	""	"The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1."	""	"TRUE"
"2828-82_2"	"SL004645"	"HAI-1"	"Kunitz-type protease inhibitor 1"	"15"	"40844018"	"40858207"	"SPINT1"	"6692"	"O43278"	""	""	""	""	""	""	""	"Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14)."	"192"	"TRUE"
"2829-19_2"	"SL006915"	"IL-27"	"Interleukin-27"	"16|19"	"28499362|4229498"	"28512051|4237531"	"IL27|EBI3"	"246778|10148"	"Q8NEV9|Q14213"	""	"IL27-mediated signaling events"	""	""	""	""	""	"Associates with EBI3 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR which appears to be required but not sufficient for IL-27-mediated signal transduction. IL-27 potentiate the early phase of TH1 response and suppress TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via two distinct pathways, p38 MAPK/TBX21- and ICAM1/ITGAL/ERK-dependent pathways. It also induces STAT1, STAT3, STAT4 and STAT5 phosphorylation and activates TBX21/T-Bet via STAT1 with resulting IL12RB2 up-regulation, an event crucial to TH1 cell commitment. It suppresses the expression of GATA3, the inhibitor TH1 cells development. In CD8 T-cells, it activates STATs as well as GZMB. IL-27 reveals to be a potent inhibitor of TH17 cell development and of IL-17 production. Indeed IL27 alone is also able to inhibit the production of IL17 by CD4 and CD8 T-cells. While IL-27 suppressed the development of proinflammatory Th17 cells via STAT1, it inhibits the development of anti-inflammatory inducible regulatory T-cells, iTreg, independently of STAT1. IL-27 has also an effect on cytokine production, it suppresses proinflammatory cytokine production such as IL2, IL4, IL5 and IL6 and activates suppressors of cytokine signaling such as SOCS1 and SOCS3. Apart from suppression of cytokine production, IL-27 also antagonizes the effects of some cytokines such as IL6 through direct effects on T-cells. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9. In vein endothelial cells, it induces IRF1/interferon regulatory factor 1 and increase the expression of MHC class II transactivator/CIITA with resulting up-regulation of major histocompatibility complex class II. IL-27 also demonstrates antiviral activity with inhibitory properties on HIV-1 replication.|Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines."	""	"TRUE"
"2831-29_1"	"SL002763"	"Kallikrein 11"	"Kallikrein-11"	"19"	"51022216"	"51028039"	"KLK11"	"11012"	"Q9UBX7"	""	""	""	""	""	""	"diagnosis"	"Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues."	""	"TRUE"
"2833-20_1"	"SL003800"	"Kallikrein 4"	"Kallikrein-4"	"19"	"50906352"	"50910738"	"KLK4"	"9622"	"Q9Y5K2"	""	"Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling"	""	""	""	""	"diagnosis|efficacy"	"Involved in enamel formation."	""	"TRUE"
"2834-54_1"	"SL003915"	"kallikrein 8"	"Kallikrein-8"	"19"	"50996007"	"51002711"	"KLK8"	"11202"	"O60259"	""	""	""	""	""	""	"diagnosis|prognosis"	"Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury."	""	"TRUE"
"2835-1_4"	"SL004301"	"Ku70"	"X-ray repair cross-complementing protein 6"	"22"	"41621119"	"41664048"	"XRCC6"	"2547"	"P12956"	"Non-homologous end joining"	"BARD1 signaling events|Coregulation of Androgen receptor activity|DNA-PK pathway in nonhomologous end joining|Regulation of Telomerase|Signaling events mediated by HDAC Class III"	""	"2-LTR circle formation|Cytosolic sensors of pathogen-associated DNA|IRF3-mediated induction of type I IFN|Nonhomologous End-joining (NHEJ)|Processing of DNA ends prior to end rejoining"	"Cell Cycle|Double Strand DNA Non-Homologous Repair|Telomere Maintenance|V(D)J Recombination"	""	"unspecified application"	"Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription."	""	"TRUE"
"2837-3_2"	"SL000134"	"Met"	"Hepatocyte growth factor receptor"	"7"	"116672390"	"116798386"	"MET"	"4233"	"P08581"	"Epithelium TarBase|Focal Adhesion|Lymphocyte TarBase|Muscle cell TarBase|Squamous cell  TarBase"	"Arf6 signaling events|Direct p53 effectors|FGF signaling pathway|Posttranslational regulation of adherens junction stability and dissassembly|Regulation of retinoblastoma protein|Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)|Signaling events mediated by TCPTP|Stabilization and expansion of the E-cadherin adherens junction|Syndecan-1-mediated signaling events|a6b1 and a6b4 Integrin signaling"	""	"Sema4D mediated inhibition of cell attachment and migration"	"Adherens Junction Assembly (Cadherins)|HGFR -> AP-1/CREB/MYC signaling|HGFR -> FOXO3A signaling|HGFR -> STAT signaling"	"crizotinib|tivantinib|cabozantinib|INC280|cabozantinib/erlotinib"	"diagnosis|disease progression|efficacy|prognosis|response to therapy|unspecified application"	"Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells."	"28"	"TRUE"
"2838-53_1"	"SL003332"	"MMP-17"	"Matrix metalloproteinase-17"	"12"	"131828393"	"131851783"	"MMP17"	"4326"	"Q9ULZ9"	"Matrix Metalloproteinases"	""	""	"Activation of Matrix Metalloproteinases"	""	"marimastat"	""	"Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin."	""	"TRUE"
"2839-2_1"	"SL004649"	"OX40 Ligand"	"Tumor necrosis factor ligand superfamily member 4"	"1"	"173183734"	"173207313"	"TNFSF4"	"7292"	"P23510"	""	""	""	""	""	""	""	"Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production."	""	"TRUE"
"2841-13_2"	"SL004650"	"sFRP-3"	"Secreted frizzled-related protein 3"	"2"	"182833275"	"182867162"	"FRZB"	"2487"	"Q92765"	"Adipogenesis|Endochondral Ossification"	""	""	""	""	""	""	"Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development."	"144"	"TRUE"
"2842-68_1"	"SL003177"	"sICAM-2"	"Intercellular adhesion molecule 2"	"17"	"64002594"	"64020634"	"ICAM2"	"3384"	"P13598"	"NA"	"NA"	"NA"	"NA"	"NA"	""	""	"ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance."	"28"	"TRUE"
"2843-13_2"	"SL001897"	"SPINT2"	"Kunitz-type protease inhibitor 2"	"19"	"38244035"	"38292614"	"SPINT2"	"10653"	"O43291"	""	""	""	""	""	""	"diagnosis"	"Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa."	"35"	"TRUE"
"2844-53_2"	"SL003199"	"sTie-1"	"Tyrosine-protein kinase receptor Tie-1, soluble"	"1"	"43300993"	"43323108"	"TIE1"	"7075"	"P35590"	""	""	""	""	""	""	""	"Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis."	"69|269|442"	"TRUE"
"2846-24_2"	"SL000605"	"Ubiquitin+1"	"Ubiquitin+1, truncated mutation for UbB"	"2"	"55231903"	"55235853"	"RPS27A"	"6233"	"P62979"	"Cytoplasmic Ribosomal Proteins"	""	""	"APC-Cdc20 mediated degradation of Nek2A|APC/C:Cdc20 mediated degradation of Cyclin B|APC/C:Cdc20 mediated degradation of Securin|APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1|AUF1 (hnRNP D0) destabilizes mRNA|Activated NOTCH1 Transmits Signal to the Nucleus|Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon|Activation of NF-kappaB in B cells|Antigen processing: Ubiquitination & Proteasome degradation|Assembly Of The HIV Virion|Association of licensing factors with the pre-replicative complex|Asymmetric localization of PCP proteins|Autodegradation of Cdh1 by Cdh1:APC/C|Autodegradation of the E3 ubiquitin ligase COP1|Budding and maturation of HIV virion|CDK-mediated phosphorylation and removal of Cdc6|CDT1 association with the CDC6:ORC:origin complex|CLEC7A (Dectin-1) signaling|Cdc20:Phospho-APC/C mediated degradation of Cyclin A|Circadian Clock|Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants|Constitutive Signaling by NOTCH1 HD Domain Mutants|Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants|Constitutive Signaling by NOTCH1 PEST Domain Mutants|Cyclin D associated events in G1|Dectin-1 mediated noncanonical NF-kB signaling|Degradation of GLI1 by the proteasome|Degradation of GLI2 by the proteasome|Degradation of beta-catenin by the destruction complex|Downregulation of ERBB2:ERBB3 signaling|Downregulation of ERBB4 signaling|Downregulation of SMAD2/3:SMAD4 transcriptional activity|Downregulation of TGF-beta receptor signaling|Downstream TCR signaling|EGFR downregulation|ER-Phagosome pathway|Endosomal Sorting Complex Required For Transport (ESCRT)|Eukaryotic Translation Termination|FCERI mediated NF-kB activation|Fanconi Anemia pathway|Formation of a pool of free 40S subunits|Formation of the ternary complex, and subsequently, the 43S complex|GLI3 is processed to GLI3R by the proteasome|GTP hydrolysis and joining of the 60S ribosomal subunit|Glycogen synthesis|Hedgehog 'on' state|Hedgehog ligand biogenesis|Hh mutants that don't undergo autocatalytic processing are degraded by ERAD|IKK complex recruitment mediated by RIP1|IRAK1 recruits IKK complex|IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation|IRAK2 mediated activation of TAK1 complex|IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation|ISG15 antiviral mechanism|Interleukin-1 signaling|JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1|L13a-mediated translational silencing of Ceruloplasmin expression|Membrane binding and targetting of GAG proteins|Myoclonic epilepsy of Lafora|NF-kB is activated and signals survival|NOD1/2 Signaling Pathway|NOTCH1 Intracellular Domain Regulates Transcription|NOTCH2 Activation and Transmission of Signal to the Nucleus|NRIF signals cell death from the nucleus|Negative regulation of FGFR1 signaling|Negative regulation of FGFR2 signaling|Negative regulation of FGFR3 signaling|Negative regulation of FGFR4 signaling|Negative regulators of RIG-I/MDA5 signaling|Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)|Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)|Oncogene Induced Senescence|Orc1 removal from chromatin|Oxidative Stress Induced Senescence|Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha|Peptide chain elongation|RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways|Recognition of DNA damage by PCNA-containing replication complex|Regulation of PLK1 Activity at G2/M Transition|Regulation of activated PAK-2p34 by proteasome mediated degradation|Regulation of innate immune responses to cytosolic DNA|Regulation of necroptotic cell death|Regulation of signaling by CBL|Regulation of the Fanconi anemia pathway|Ribosomal scanning and start codon recognition|SCF(Skp2)-mediated degradation of p27/p21|SCF-beta-TrCP mediated degradation of Emi1|SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription|SRP-dependent cotranslational protein targeting to membrane|Senescence-Associated Secretory Phenotype (SASP)|Separation of Sister Chromatids|Signaling by ERBB2|Spry regulation of FGF signaling|Stimuli-sensing channels|TAK1 activates NFkB by phosphorylation and activation of IKKs complex|TCF dependent signaling in response to WNT|TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)|TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling|TRAF6 mediated induction of TAK1 complex|Termination of translesion DNA synthesis|Translation initiation complex formation|Translesion Synthesis by POLH|Translesion synthesis by POLI|Translesion synthesis by POLK|Translesion synthesis by REV1|Ubiquitin Mediated Degradation of Phosphorylated Cdc25A|Ubiquitin-dependent degradation of Cyclin D1|Vif-mediated degradation of APOBEC3G|Viral mRNA Translation|Vpu mediated degradation of CD4|activated TAK1 mediates p38 MAPK activation|deactivation of the beta-catenin transactivating complex|degradation of AXIN|degradation of DVL|p75NTR recruits signalling complexes|regulation of FZD by ubiquitination"	""	""	""	"Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling."	""	"TRUE"
"2848-2_2"	"SL004652"	"WIF-1"	"Wnt inhibitory factor 1"	"12"	"65050626"	"65121566"	"WIF1"	"11197"	"Q9Y5W5"	""	"Presenilin action in Notch and Wnt signaling|Wnt signaling network"	""	"negative regulation of TCF-dependent signaling by WNT ligand antagonists"	""	""	"efficacy"	"Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation."	""	"TRUE"
"2849-49_1"	"SL004768"	"AIF1"	"Allograft inflammatory factor 1"	"6"	"31597358"	"31693314"	"AIF1"	"199"	"P55008"	""	""	""	""	""	""	""	"Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation."	""	"TRUE"
"2850-3_2"	"SL008008"	"ARGI1"	"Arginase-1"	"6"	"131573144"	"131584332"	"ARG1"	"383"	"P05089"	"NA"	"NA"	"NA"	"NA"	"NA"	""	""	"L-arginine + H(2)O = L-ornithine + urea."	""	"TRUE"
"2851-63_3"	"SL000320"	"C5a"	"C5a anaphylatoxin"	"9"	"120952335"	"121050276"	"C5"	"727"	"P01031"	"Complement Activation, Classical Pathway"	""	""	"Activation of C3 and C5|G alpha (i) signalling events|Peptide ligand-binding receptors|Regulation of Complement cascade|Terminal pathway of complement"	"Alternative Complement Pathway|Classical Complement Pathway|Lectin-Induced Complement Pathway"	"eculizumab|IgG"	""	"Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled."	""	"TRUE"
"2853-68_2"	"SL006911"	"CHK1"	"Serine/threonine-protein kinase Chk1"	"11"	"125625136"	"125676255"	"CHEK1"	"1111"	"O14757"	"Cell cycle|DNA damage response|Integrated Breast Cancer Pathway|Integrated Cancer pathway|miRNA regulation of DNA Damage Response"	"ATR signaling pathway|Circadian rhythm pathway|Fanconi anemia pathway|p53 pathway|p73 transcription factor network"	""	"Activation of ATR in response to replication stress|Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex|G2/M DNA damage checkpoint|Signaling by SCF-KIT|Ubiquitin Mediated Degradation of Phosphorylated Cdc25A"	"Cell Cycle"	"UCN-01"	"efficacy"	"Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C. Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of CDC25A. Phosphorylation of CDC25A at 'Ser-76' primes the protein for subsequent phosphorylation at 'Ser-79', 'Ser-82' and 'Ser-88' by NEK11, which is required for polyubiquitination and degradation of CDCD25A. Inhibition of CDC25 leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. Also phosphorylates NEK6. Binds to and phosphorylates RAD51 at 'Thr-309', which promotes the release of RAD51 from BRCA2 and enhances the association of RAD51 with chromatin, thereby promoting DNA repair by homologous recombination. Phosphorylates multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and promotes cell cycle arrest and suppression of cellular proliferation. Also promotes repair of DNA cross-links through phosphorylation of FANCE. Binds to and phosphorylates TLK1 at 'Ser-743', which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A. This may enhance chromatin assembly both in the presence or absence of DNA damage. May also play a role in replication fork maintenance through regulation of PCNA. May regulate the transcription of genes that regulate cell-cycle progression through the phosphorylation of histones. Phosphorylates histone H3.1 (to form H3T11ph), which leads to epigenetic inhibition of a subset of genes. May also phosphorylate RB1 to promote its interaction with the E2F family of transcription factors and subsequent cell cycle arrest."	""	"TRUE"
"2855-49_2"	"SL000409"	"ERK-1"	"Mitogen-activated protein kinase 3"	"16"	"30114105"	"30123506"	"MAPK3"	"5595"	"P27361"	"Alpha 6 Beta 4 signaling pathway|Alzheimers Disease|Apoptosis Modulation and Signaling|EPO Receptor Signaling|FSH signaling pathway|Hypothetical Network for Drug Addiction|IL-1 signaling pathway|IL-2 Signaling pathway|IL-3 Signaling Pathway|IL-4 signaling pathway|IL-5 signaling pathway|IL-6 signaling pathway|IL-7 signaling pathway|IL-9 signaling pathway|Insulin Signaling|Kit receptor signaling pathway|Leptin signaling pathway|MAPK Cascade|MAPK signaling pathway|MicroRNAs in cardiomyocyte hypertrophy|Osteopontin Signaling|Prolactin Signaling Pathway|RANKL/RANK Signaling Pathway|Regulation of Actin Cytoskeleton|Regulation of toll-like receptor signaling pathway|Serotonin HTR1 Group and FOS Pathway|Serotonin Receptor 2 and ELK-SRF/GATA4 signaling|Serotonin Receptor 4/6/7 and NR3C Signaling|Signal Transduction of S1P Receptor|Signaling of Hepatocyte Growth Factor Receptor|TCR Signaling Pathway|TGF Beta Signaling Pathway|TNF alpha Signaling Pathway|TSH signaling pathway|TWEAK Signaling Pathway|Toll-like receptor signaling pathway"	"ALK1 signaling events|ATF-2 transcription factor network|Alpha-synuclein signaling|Angiopoietin receptor Tie2-mediated signaling|Arf6 downstream pathway|BCR signaling pathway|CDC42 signaling events|CXCR3-mediated signaling events|Cellular roles of Anthrax toxin|Ceramide signaling pathway|Downstream signaling in naïve CD8+ T cells|EGF receptor (ErbB1) signaling pathway|EPHB forward signaling|Endothelins|ErbB1 downstream signaling|ErbB2/ErbB3 signaling events|ErbB4 signaling events|FGF signaling pathway|Fc-epsilon receptor I signaling in mast cells|GMCSF-mediated signaling events|Glucocorticoid receptor regulatory network|IFN-gamma pathway|IL2-mediated signaling events|Integrins in angiogenesis|Netrin-mediated signaling events|Neurotrophic factor-mediated Trk receptor signaling|Nongenotropic Androgen signaling|Osteopontin-mediated events|PDGFR-beta signaling pathway|Presenilin action in Notch and Wnt signaling|Ras signaling in the CD4+ TCR pathway|Regulation of Telomerase|Regulation of cytoplasmic and nuclear SMAD2/3 signaling|Retinoic acid receptors-mediated signaling|Role of Calcineurin-dependent NFAT signaling in lymphocytes|S1P1 pathway|S1P2 pathway|S1P3 pathway|S1P4 pathway|Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)|Signaling events mediated by PRL|Signaling events mediated by Stem cell factor receptor (c-Kit)|Signaling events mediated by VEGFR1 and VEGFR2|Signaling events regulated by Ret tyrosine kinase|Syndecan-1-mediated signaling events|Syndecan-2-mediated signaling events|TRAIL signaling pathway|Trk receptor signaling mediated by the MAPK pathway|VEGFR1 specific signals|VEGFR3 signaling in lymphatic endothelium|mTOR signaling pathway"	""	"Activation of the AP-1 family of transcription factors|Advanced glycosylation endproduct receptor signaling|ERK/MAPK targets|ERK1 activation|ERKs are inactivated|FCERI mediated MAPK activation|Gastrin-CREB signalling pathway via PKC and MAPK|Golgi Cisternae Pericentriolar Stack Reorganization|Growth hormone receptor signaling|ISG15 antiviral mechanism|NCAM signaling for neurite out-growth|Negative regulation of FGFR1 signaling|Negative regulation of FGFR2 signaling|Negative regulation of FGFR3 signaling|Negative regulation of FGFR4 signaling|Oncogene Induced Senescence|Oxidative Stress Induced Senescence|RHO GTPases Activate WASPs and WAVEs|RNA Polymerase I Promoter Opening|Regulation of HSF1-mediated heat shock response|Regulation of actin dynamics for phagocytic cup formation|Senescence-Associated Secretory Phenotype (SASP)|Signal attenuation|Signal transduction by L1|Signaling by FGFR1|Signaling by FGFR2|Signaling by FGFR3|Signaling by FGFR4|Thrombin signalling through proteinase activated receptors (PARs)"	"ADRA1 -> prostaglandin generation|ADRA1 -> vasoconstriction|ADRA1A -> IL6 production|ADRA2C/ADRB2 -> vasoconstriction|ADRB1 -> prostaglandin generation|AGER ->  CREB/SP1 signaling|AdenosineR -> AP-1 signaling|AdrenergicRa -> ELK-SRF signaling|AdrenergicRb -> CREB signaling|AdrenergicRb -> STAT3 signaling|AngiopoietinR -> AP-1 signaling|AngiotensinR -> CREB/ELK-SRF/TP53 signaling|B-cell receptor -> AP-1 signaling|BDKRB1/2 -> prostaglandin generation|CD19 ->  AP-1/ELK-SRF signaling|CD38 ->  NF-kB signaling|CD8+ T-cell Activation|CHRM1 -> IL2 production|CHRM1/2/3 -> vascular motility|CHRNA7 -> NOS1 production|CNR1/2 -> IL1B/2/4/6/10 production|CannabinoidR -> AP-1/EGR signaling|Cell Cycle|CholecystokininR -> ELK-SRF signaling|CholinergicRm -> CREB/ELK-SRF signaling|CholinergicRn ->  CREB signaling|DopamineR1 -> CREB/ELK-SRF signaling|DopamineR2 -> AP-1/CREB/ELK-SRF signaling|EDG2 -> ELK-SRF signaling|EDG3/5 -> AP-1/ELK-SRF signaling|EDNRA/B -> vascular motility|EGFR -> AP-1/ATF2 signaling|EGFR -> AP-1/CREB/ELK-SRF/MYC signaling|EGFR/ERBB2 -> TP53 signaling|ERBB2/3 -> EP300/ETS/ETV/SP1 signaling|EctodysplasinR -> AP-1 signaling|EndothelinRa -> AP-1/CREB signaling|EndothelinRb -> AP-1/CREB/ELK-SRF signaling|ErythropoietinR -> AP-1/CREB/MYC signaling|ErythropoietinR -> ELK-SRF/FOS signaling|FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling|FGFR -> RUNX2 signaling|FSHR -> CREB/ELK-SRF/GATA4 signaling|FcIgER -> ELK-SRF signaling|FibronectinR -> AP-1/ELK-SRF/SREBF signaling|GABA(B)R -> postsynaptic inhibition|GALR1/2/3 -> POMC/NPY production|GDNF -> HSF1 signaling|GHR -> ELK-SRF/MYC signaling|GNRHR -> ELK-SRF signaling|GRM1/5 -> CREB signaling|Gap Junction Assembly|GlucagonR -> CREB/ELK-SRF/SP1 signaling|HGFR -> AP-1/CREB/MYC signaling|HRH2/4 -> IL6/10 production|HTR1 -> IL6 production|HTR5 -> TNF production|HTR7 -> IL6 production|ICAM1 -> AP-1/CREB/ELK-SRF signaling|IGF1R -> ELK-SRF/HIF1A/MYC/SREBF signaling|IL1R -> NF-kB signaling|IL2R -> ELK-SRF/MYC signaling|IL4R -> ELK-SRF/HMGY signaling|IL6R -> CEBP/ELK-SRF signaling|IL8R -> CREB/EGR signaling|InsulinR -> ELK-SRF/SREBF signaling|LeptinR -> ELK-SRF signaling|Model of T-cell Maturation|NCAM1 -> CREB/ELK-SRF/MYC signaling|NGFR -> AP-1/CEBPB/CREB/ELK-SRF/TP53 signaling|NMDA receptors -> Ca2+/CREB activation/PGE2 synthesis|NPY1R -> CRH/POMC production|NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling|Natural Killer Cell Activation|Natural Killer Cell Activation through C-type Lectin-like Receptors|Natural Killer Cell Activation through ITAM-Containing Receptors|Natural Killer Cell Activation through ITSM-Containing Receptors|NeuropeptideYR -> ATF/CREB signaling|NeurotensinR -> ELK-SRF/AP-1/EGR signaling|Nociception-related DRD1/5 expression targets|Nociception-related DRD2 expression targets|Nociception-related IL1B expression targets|Nociception-related NTSR1 expression targets|Notch -> TCF3 signaling|OPRK -> pain perception|OpioidR -> CREB/ELK-SRF/STAT3 signaling|OxytocinR -> ELK-SRF/GATA/AP-1 signaling|P2RY11/13/14 -> IL8/10 production|PDGFR -> AP-1/MYC signaling|PECAM -> SP1 signaling|PTAFR -> AP-1/ATF1/CREB/ERK-SRF signaling|PTGER1/4 -> vascular motility|PTGER2/3 -> inflammation-related expression targets|PTGIR -> IL6 production|PTPRC -> BCL6 signaling|ProstaglandinFR -> ATF1/ELK-SRF/CREB signaling|ProstaglandinIR -> ATF1/ELK-SRF/CREB signaling|Regulatory T-cell Differentiation|SELE -> ELK-SRF signaling|SerotoninR1 -> FOS signaling|SerotoninR2 -> ELK-SRF/GATA4 signaling|SerotoninR4/6/7 -> NR3C signaling|Summarized nociception-related expression targets|Summarized vascular motility pathway|T-cell Receptor Signaling|T-cell receptor -> AP-1 signaling|T-cell-Dependent B-cell Activation|T-cell-Independent B-cell Activation|TNFR -> AP-1/ATF/TP53 signaling|TNFR -> CREB/ELK-SRF signaling|TNFRSF1A -> AP-1/ATF/TP53 signaling|TNFRSF1A -> CREB/ELK-SRF signaling|TNFRSF6 -> HSF1 signaling|TachykininR -> ELK-SRF signaling|Th1 Cell Differentiation|Th2 Cell Differentiation|ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling|ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling|ThrombopoietinR -> SP1 signaling|ThromboxaneR -> CREB signaling|UrokinaseR -> ELK-SRF signaling|V(D)J Recombination Activation|VEGFR -> AP-1/CREB/MYC signaling|VEGFR -> ATF/CREB/ELK-SRF signaling|VIPR -> CREB/CEBP signaling|VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling|VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling"	""	"efficacy"	"Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade."	""	"FALSE"
"2857-70_2"	"SL006914"	"Glucocorticoid receptor"	"Glucocorticoid receptor"	"5"	"143277931"	"143435512"	"NR3C1"	"2908"	"P04150"	"Adipogenesis|Nuclear Receptors|SIDS Susceptibility Pathways|Serotonin Receptor 4/6/7 and NR3C Signaling"	"AP-1 transcription factor network|FOXA2 and FOXA3 transcription factor networks|Glucocorticoid receptor regulatory network|Regulation of Androgen receptor activity|Regulation of nuclear SMAD2/3 signaling|Signaling events mediated by HDAC Class II"	""	"BMAL1:CLOCK,NPAS2 activates circadian gene expression|Nuclear Receptor transcription pathway"	"HTR7 -> IL6 production|SRCAP Chromatin Remodeling|SWI/SNF BRG1/BAF Chromatin Remodeling|SWI/SNF BRG1/PBAF Chromatin Remodeling|SWI/SNF BRM/BAF Chromatin Remodeling|SerotoninR4/6/7 -> NR3C signaling"	"rimexolone|medrysone|clocortolone pivalate|diflorasone diacetate|fluorometholone|dexamethasone phosphate|cortisone acetate|halcinonide|flurandrenolide|desoximetasone|desonide|prednisolone|clobetasol propionate|fluocinolone acetonide|prednisone|hydrocortisone|triamcinolone|dexamethasone 21-acetate|11beta hydrocortisone acetate|betamethasone|dexamethasone|budesonide|fluticasone|beclomethasone dipropionate|betamethasone acetate/betamethasone phosphate|betamethasone acetate|triamcinolone acetonide|ciprofloxacin/hydrocortisone|ciprofloxacin/dexamethasone|ORG 34517|ciclesonide|betamethasone dipropionate/calcipotriene|fluticasone furoate|budesonide/formoterol|difluprednate|formoterol/mometasone furoate|beclomethasone|fluticasone furoate/vilanterol|azelastine/fluticasone propionate|beclomethasone 17-monopropionate|dexamethasone/lenalidomide/sorafenib|docetaxel/prednisone|carmustine/prednisone|cabazitaxel/prednisone|dexamethasone/lenalidomide|hydrocortisone/prednisone|dexamethasone/thalidomide|cyclophosphamide/prednisone/vincristine|hydrocortisone/mitoxantrone|mitoxantrone/prednisone|docetaxel/hydrocortisone|6-mercaptopurine/methotrexate/prednisone/vincristine|cytarabine/dexamethasone|dexamethasone/pomalidomide|bortezomib/dexamethasone|cyclophosphamide/dexamethasone/thalidomide|bortezomib/dexamethasone/doxorubicin|bortezomib/dexamethasone/lenalidomide|bortezomib/dexamethasone/thalidomide|dexamethasone/doxorubicin/vincristine|carfilzomib/dexamethasone/lenalidomide|cyclophosphamide/daunorubicin/imatinib/prednisone/vincristine|bortezomib/prednisone|cyclophosphamide/dexamethasone/rituximab|cyclophosphamide/prednisone/rituximab|prednisone/thalidomide|octreotide/prednisone|bortezomib/dexamethasone/rituximab|L-asparaginase/prednisone/vincristine|cyclophosphamide/prednisone|dexamethasone/fludarabine phosphate/mitoxantrone|cyclophosphamide/etoposide/prednisone/rituximab/vincristine|cytarabine/dexamethasone/methotrexate|cyclophosphamide/mitoxantrone/prednisone/vincristine|cyclophosphamide/etoposide/prednisone/vincristine|dexamethasone/fludarabine phosphate/mitoxantrone/rituximab|chlorambucil/mitoxantrone/prednisone|cyclophosphamide/prednisone/rituximab/vincristine|methylprednisolone/rituximab|cyclophosphamide/mitoxantrone/prednisone/rituximab/vincristine|chlorambucil/mitoxantrone/prednisone/rituximab|clocortolone|alclometasone|loteprednol|dasatinib/dexamethasone/vincristine|prednisone/somatotropin|carfilzomib/dexamethasone/rituximab|cyclophosphamide/prednisolone/vincristine|cyclophosphamide/prednisolone/rituximab/vincristine|fluticasone/salmeterol|betamethasone/clotrimazole|miconazole|prednisolone acetate|methylprednisolone acetate|mometasone furoate|amcinonide|methylprednisolone succinate|betamethasone phosphate|fluocinonide|prednicarbate|hydrocortisone cypionate|hydrocortisone succinate|prednisolone phosphate|betamethasone valerate|betamethasone benzoate|fludrocortisone acetate|prednisolone tebutate|betamethasone dipropionate|hydrocortisone buteprate|alclometasone dipropionate|hydrocortisone butyrate|fluorometholone acetate|hydrocortisone valerate|loteprednol etabonate|hydrocortisone phosphate|methylprednisolone|halobetasol propionate|flunisolide|mifepristone"	"efficacy"	"Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression."	""	"TRUE"
"2858-29_2"	"SL004725"	"Hat1"	"Histone acetyltransferase type B catalytic subunit"	"2"	"171922448"	"171983682"	"HAT1"	"8520"	"O14929"	""	""	""	"HATs acetylate histones"	"NURD Chromatin Remodeling|SWI/SNF BRG1/BAF Chromatin Remodeling|SWI/SNF BRG1/PBAF Chromatin Remodeling|SWI/SNF BRM/BAF Chromatin Remodeling"	""	""	"Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage."	""	"TRUE"
"2859-69_2"	"SL004723"	"HDAC8"	"Histone deacetylase 8"	"X"	"72329516"	"72573103"	"HDAC8"	"55869"	"Q9BY41"	"Cell cycle|Neural Crest Differentiation"	"Signaling events mediated by HDAC Class I"	""	"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants|Constitutive Signaling by NOTCH1 PEST Domain Mutants|HDACs deacetylate histones|NOTCH1 Intracellular Domain Regulates Transcription|Resolution of Sister Chromatid Cohesion|Separation of Sister Chromatids"	""	"tributyrin|belinostat|pyroxamide|romidepsin"	""	"Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility."	""	"TRUE"
"2860-19_2"	"SL004718"	"Karyopherin-a2"	"Importin subunit alpha-1"	"17"	"68035519"	"68046842"	"KPNA2"	"3838"	"P52292"	""	"Regulation of cytoplasmic and nuclear SMAD2/3 signaling|Role of Calcineurin-dependent NFAT signaling in lymphocytes|Signaling events mediated by TCPTP"	""	"ISG15 antiviral mechanism"	"Histone Acetylation|Protein Nuclear Import and Export"	""	"diagnosis"	"Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus."	""	"TRUE"
"2864-2_3"	"SL003793"	"MEK1"	"Dual specificity mitogen-activated protein kinase kinase 1"	"15"	"66386817"	"66492312"	"MAP2K1"	"5604"	"Q02750"	"B Cell Receptor Signaling Pathway|EGF/EGFR Signaling Pathway|EPO Receptor Signaling|ErbB signaling pathway|Estrogen signaling pathway|Focal Adhesion|Hypothetical Network for Drug Addiction|IL-1 signaling pathway|IL-2 Signaling pathway|IL-3 Signaling Pathway|IL-5 signaling pathway|IL-6 signaling pathway|IL-7 signaling pathway|IL-9 signaling pathway|Insulin Signaling|Integrin-mediated cell adhesion|Kit receptor signaling pathway|Leptin signaling pathway|MAPK Cascade|MAPK signaling pathway|MicroRNAs in cardiomyocyte hypertrophy|Nifedipine Activity|Osteopontin Signaling|Prolactin Signaling Pathway|RANKL/RANK Signaling Pathway|Regulation of Actin Cytoskeleton|Regulation of toll-like receptor signaling pathway|Senescence and Autophagy|Serotonin HTR1 Group and FOS Pathway|Serotonin Receptor 2 and ELK-SRF/GATA4 signaling|Serotonin Receptor 4/6/7 and NR3C Signaling|Signaling of Hepatocyte Growth Factor Receptor|TCR Signaling Pathway|TGF beta Signaling Pathway|TSH signaling pathway|Toll-like receptor signaling pathway|angiogenesis overview"	"BCR signaling pathway|CXCR3-mediated signaling events|Cellular roles of Anthrax toxin|Ceramide signaling pathway|Class IB PI3K non-lipid kinase events|Downstream signaling in naïve CD8+ T cells|EPHB forward signaling|Endothelins|ErbB1 downstream signaling|ErbB2/ErbB3 signaling events|FOXM1 transcription factor network|Fc-epsilon receptor I signaling in mast cells|GMCSF-mediated signaling events|Hedgehog signaling events mediated by Gli proteins|IFN-gamma pathway|IL2-mediated signaling events|Netrin-mediated signaling events|Neurotrophic factor-mediated Trk receptor signaling|Nongenotropic Androgen signaling|PDGFR-beta signaling pathway|Ras signaling in the CD4+ TCR pathway|SHP2 signaling|Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)|Signaling events mediated by Stem cell factor receptor (c-Kit)|Signaling events mediated by VEGFR1 and VEGFR2|Signaling events mediated by focal adhesion kinase|Trk receptor signaling mediated by the MAPK pathway|mTOR signaling pathway"	""	"ERK1 activation|Interleukin-1 signaling|MEK activation|RAF phosphorylates MEK|Signal transduction by L1|Signaling by FGFR1|Signaling by FGFR2|Signaling by FGFR3|Signaling by FGFR4|Uptake and function of anthrax toxins"	"ADRA1 -> prostaglandin generation|ADRA1 -> vasoconstriction|ADRA1A -> IL6 production|ADRA2C/ADRB2 -> synaptic endocytosis|ADRA2C/ADRB2 -> vasoconstriction|ADRB1 -> prostaglandin generation|AGER ->  CREB/SP1 signaling|AdenosineR -> AP-1 signaling|AdrenergicRa -> ELK-SRF signaling|AdrenergicRa -> STAT3 signaling|AdrenergicRb -> CREB signaling|AdrenergicRb -> STAT3 signaling|AngiopoietinR -> AP-1 signaling|AngiotensinR -> CREB/ELK-SRF/TP53 signaling|B-cell receptor -> AP-1 signaling|BDKRB1/2 -> prostaglandin generation|CD19 ->  AP-1/ELK-SRF signaling|CD38 ->  NF-kB signaling|CD8+ T-cell Activation|CHRM1 -> IL2 production|CHRM1/2/3 -> vascular motility|CHRNA7 -> NOS1 production|CNR1/2 -> IL1B/2/4/6/10 production|CannabinoidR -> AP-1/EGR signaling|CholecystokininR -> ELK-SRF signaling|CholinergicRm -> CREB/ELK-SRF signaling|CholinergicRn ->  CREB signaling|DopamineR1 -> CREB/ELK-SRF signaling|DopamineR2 -> AP-1/CREB/ELK-SRF signaling|EDG2 -> ELK-SRF signaling|EDG3/5 -> AP-1/ELK-SRF signaling|EDNRA/B -> vascular motility|EGFR -> AP-1/ATF2 signaling|EGFR -> AP-1/CREB/ELK-SRF/MYC signaling|EGFR -> NCOR2 signaling|EGFR -> SMAD1 signaling|EGFR/ERBB2 -> HIF1A signaling|EGFR/ERBB2 -> TP53 signaling|ERBB2/3 -> EP300/ETS/ETV/SP1 signaling|EctodysplasinR -> AP-1 signaling|EndothelinRa -> AP-1/CREB signaling|EndothelinRb -> AP-1/CREB/ELK-SRF signaling|ErythropoietinR -> AP-1/CREB/MYC signaling|ErythropoietinR -> ELK-SRF/FOS signaling|FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling|FGFR -> RUNX2 signaling|FSHR -> CREB/ELK-SRF/GATA4 signaling|FcIgER -> ELK-SRF signaling|FibronectinR -> AP-1/ELK-SRF/SREBF signaling|GABA(B)R -> postsynaptic inhibition|GALR1/2/3 -> POMC/NPY production|GDNF -> HSF1 signaling|GHR -> ELK-SRF/MYC signaling|GNRHR -> ELK-SRF signaling|GRM1/5 -> CREB signaling|GlucagonR -> CREB/ELK-SRF/SP1 signaling|HGFR -> AP-1/CREB/MYC signaling|HRH2/4 -> IL6/10 production|HTR1 -> IL6 production|HTR5 -> TNF production|HTR7 -> IL6 production|ICAM1 -> AP-1/CREB/ELK-SRF signaling|IGF1R -> ELK-SRF/HIF1A/MYC/SREBF signaling|IL1R -> NF-kB signaling|IL2R -> ELK-SRF/MYC signaling|IL4R -> ELK-SRF/HMGY signaling|IL6R -> CEBP/ELK-SRF signaling|IL8R -> CREB/EGR signaling|InsulinR -> ELK-SRF/SREBF signaling|KIT -> MITF signaling|LeptinR -> ELK-SRF signaling|Model of T-cell Maturation|NCAM1 -> CREB/ELK-SRF/MYC signaling|NGFR -> AP-1/CEBPB/CREB/ELK-SRF/TP53 signaling|NMDA receptors -> Ca2+/CREB activation/PGE2 synthesis|NPY1R -> CRH/POMC production|NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling|Natural Killer Cell Activation|Natural Killer Cell Activation through C-type Lectin-like Receptors|Natural Killer Cell Activation through ITAM-Containing Receptors|Natural Killer Cell Activation through ITSM-Containing Receptors|Natural Killer Cell Activation through Integrins and non-ITAM-Containing Receptors|Natural Killer Cell Inhibitory Receptor Signaling|NeuropeptideYR -> ATF/CREB signaling|NeurotensinR -> ELK-SRF/AP-1/EGR signaling|Nociception-related DRD1/5 expression targets|Nociception-related DRD2 expression targets|Nociception-related IL1B expression targets|Nociception-related IL6 expression targets|Nociception-related NTSR1 expression targets|Notch -> TCF3 signaling|OPRK -> pain perception|OpioidR -> CREB/ELK-SRF/STAT3 signaling|OxytocinR -> ELK-SRF/GATA/AP-1 signaling|P2RY11/13/14 -> IL8/10 production|PDGFR -> AP-1/MYC signaling|PECAM -> SP1 signaling|PTAFR -> AP-1/ATF1/CREB/ERK-SRF signaling|PTGER1/4 -> vascular motility|PTGER2/3 -> inflammation-related expression targets|PTGIR -> IL6 production|PTPRC -> BCL6 signaling|ProstaglandinFR -> ATF1/ELK-SRF/CREB signaling|ProstaglandinIR -> ATF1/ELK-SRF/CREB signaling|Regulatory T-cell Differentiation|SELE -> ELK-SRF signaling|SerotoninR1 -> FOS signaling|SerotoninR2 -> ELK-SRF/GATA4 signaling|SerotoninR4/6/7 -> NR3C signaling|Summarized nociception-related expression targets|Summarized vascular motility pathway|T-cell Receptor Signaling|T-cell receptor -> AP-1 signaling|T-cell-Dependent B-cell Activation|T-cell-Independent B-cell Activation|TNFR -> AP-1/ATF/TP53 signaling|TNFR -> CREB/ELK-SRF signaling|TNFRSF1A -> AP-1/ATF/TP53 signaling|TNFRSF1A -> CREB/ELK-SRF signaling|TNFRSF6 -> HSF1 signaling|TachykininR -> ELK-SRF signaling|Th1 Cell Differentiation|Th2 Cell Differentiation|ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling|ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling|ThrombopoietinR -> SP1 signaling|ThromboxaneR -> CREB signaling|UrokinaseR -> ELK-SRF signaling|VEGFR -> AP-1/CREB/MYC signaling|VEGFR -> ATF/CREB/ELK-SRF signaling|VIPR -> CREB/CEBP signaling|VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling|VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling"	"selumetinib|trametinib|dabrafenib/trametinib"	""	"Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis."	""	"TRUE"
"2865-77_2"	"SL004724"	"MOZ"	"Histone acetyltransferase KAT6A"	"8"	"41929479"	"42051990"	"KAT6A"	"7994"	"Q92794"	""	""	""	"HATs acetylate histones"	""	""	""	"Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML."	""	"TRUE"
"2869-68_3"	"SL000554"	"PKC-D"	"Protein kinase C delta type"	"3"	"53156009"	"53192717"	"PRKCD"	"5580"	"Q05655"	"Alpha 6 Beta 4 signaling pathway|B Cell Receptor Signaling Pathway|Calcium Regulation in the Cardiac Cell|EGF/EGFR Signaling Pathway|G Protein Signaling Pathways|IL-6 signaling pathway|Insulin Signaling|MAPK signaling pathway|Myometrial Relaxation and Contraction Pathways|TCR Signaling Pathway|Type II diabetes mellitus|Type II interferon signaling (IFNG)|Wnt Signaling Pathway|Wnt Signaling Pathway and Pluripotency|miRs in Muscle Cell Differentiation"	"Alpha-synuclein signaling|Ceramide signaling pathway|Endothelins|ErbB1 downstream signaling|Hedgehog signaling events mediated by Gli proteins|IFN-gamma pathway|IGF1 pathway|IL6-mediated signaling events|LPA receptor mediated events|PAR1-mediated thrombin signaling events|PDGFR-beta signaling pathway|Role of Calcineurin-dependent NFAT signaling in lymphocytes|Signaling events mediated by VEGFR1 and VEGFR2|Syndecan-2-mediated signaling events|Syndecan-4-mediated signaling events|Thromboxane A2 receptor signaling|Trk receptor signaling mediated by PI3K and PLC-gamma|Trk receptor signaling mediated by the MAPK pathway|Validated transcriptional targets of TAp63 isoforms|p53 pathway"	""	"Apoptotic cleavage of cellular proteins|CLEC7A (Dectin-1) signaling|Calmodulin induced events|DAG and IP3 signaling|Effects of PIP2 hydrolysis|G alpha (z) signalling events|HuR stabilizes mRNA|Interferon gamma signaling|Role of phospholipids in phagocytosis|VEGFR2 mediated cell proliferation"	"Cleavage of Lamina in Apoptosis|Golgi to Endosome Transport|IL1R -> STAT3 signaling"	"ingenol mebutate"	""	"Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction. Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53. In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53. In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation. Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1. Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways. May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA. In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation. Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release. Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin. The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity)."	""	"TRUE"
"2870-29_2"	"SL004009"	"RAC1"	"Ras-related C3 botulinum toxin substrate 1"	"7"	"6374523"	"6403977"	"RAC1"	"5879"	"P63000"	"Alpha 6 Beta 4 signaling pathway|Androgen receptor signaling pathway|B Cell Receptor Signaling Pathway|DNA damage response (only ATM dependent)|EGF/EGFR Signaling Pathway|Focal Adhesion|G13 Signaling Pathway|IL-6 signaling pathway|Insulin Signaling|Integrated Breast Cancer Pathway|Integrin-mediated cell adhesion|Leptin signaling pathway|MAPK signaling pathway|MicroRNAs in cardiomyocyte hypertrophy|NOD pathway|Physiological and Pathological Hypertrophy  of the Heart|Prolactin Signaling Pathway|RANKL/RANK Signaling Pathway|Regulation of Actin Cytoskeleton|Regulation of toll-like receptor signaling pathway|TGF beta Signaling Pathway|TNF alpha Signaling Pathway|TOR signaling|TWEAK Signaling Pathway|Toll-like receptor signaling pathway|Wnt Signaling Pathway|angiogenesis overview|p38 MAPK Signaling Pathway"	"Alpha4 beta1 integrin signaling events|Alpha9 beta1 integrin signaling events|Angiopoietin receptor Tie2-mediated signaling|Arf1 pathway|Arf6 downstream pathway|BCR signaling pathway|CDC42 signaling events|CXCR4-mediated signaling events|Class I PI3K signaling events|E-cadherin signaling in keratinocytes|E-cadherin signaling in the nascent adherens junction|EPHA2 forward signaling|EPHB forward signaling|Endothelins|Ephrin B reverse signaling|ErbB1 downstream signaling|ErbB2/ErbB3 signaling events|IL2 signaling events mediated by PI3K|IL6-mediated signaling events|Integrin-linked kinase signaling|Integrins in angiogenesis|LPA receptor mediated events|Lissencephaly gene (LIS1) in neuronal migration and development|N-cadherin signaling events|Nectin adhesion pathway|Nephrin/Neph1 signaling in the kidney podocyte|Netrin-mediated signaling events|Neurotrophic factor-mediated Trk receptor signaling|Noncanonical Wnt signaling pathway|Nongenotropic Androgen signaling|Osteopontin-mediated events|PDGFR-beta signaling pathway|Posttranslational regulation of adherens junction stability and dissassembly|RAC1 signaling pathway|Regulation of RAC1 activity|Regulation of p38-alpha and p38-beta|S1P1 pathway|S1P2 pathway|S1P3 pathway|Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)|Signaling events mediated by PRL|Signaling events mediated by focal adhesion kinase|Signaling events regulated by Ret tyrosine kinase|Syndecan-4-mediated signaling events|Thromboxane A2 receptor signaling|Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling|a6b1 and a6b4 Integrin signaling|mTOR signaling pathway|p38 MAPK signaling pathway|p75(NTR)-mediated signaling"	""	"Activation of Rac|CD28 dependent Vav1 pathway|DAP12 signaling|DCC mediated attractive signaling|DSCAM interactions|EPH-ephrin mediated repulsion of cells|EPHB-mediated forward signaling|Ephrin signaling|FCERI mediated MAPK activation|Factors involved in megakaryocyte development and platelet production|G alpha (12/13) signalling events|GPVI-mediated activation cascade|Inactivation of Cdc42 and Rac|NRAGE signals death through JNK|Nef and signal transduction|PCP/CE pathway|RHO GTPases Activate Formins|RHO GTPases Activate NADPH Oxidases|RHO GTPases Activate WASPs and WAVEs|RHO GTPases activate CIT|RHO GTPases activate IQGAPs|RHO GTPases activate KTN1|RHO GTPases activate PAKs|RHO GTPases activate PKNs|Regulation of actin dynamics for phagocytic cup formation|Rho GTPase cycle|SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion|Sema3A PAK dependent Axon repulsion|Sema4D induced cell migration and growth-cone collapse|Sema4D mediated inhibition of cell attachment and migration|Signal transduction by L1|Signaling by SCF-KIT|Translocation of GLUT4 to the plasma membrane|VEGFA-VEGFR2 Pathway|VEGFR2 mediated vascular permeability"	"AGER ->  CREB/SP1 signaling|Adherens Junction Assembly (Cadherins)|Adherens Junction Assembly (Nectin)|AngiopoietinR -> AP-1 signaling|DopamineR2 -> AP-1/CREB/ELK-SRF signaling|EDG2 -> ELK-SRF signaling|EGFR -> AP-1/ATF2 signaling|EGFR -> AP-1/CREB/ELK-SRF/MYC signaling|EGFR -> NCOR2 signaling|EGFR/ERBB2 -> TP53 signaling|EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG signaling|EndothelinRb -> AP-1/CREB/ELK-SRF signaling|ErythropoietinR -> AP-1/CREB/MYC signaling|FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling|FcIgER -> ELK-SRF signaling|FibronectinR -> AP-1/ELK-SRF/SREBF signaling|FibronectinR -> NF-kB signaling|FrizzledR -> JUN/PAX2 signaling|GDNF -> HSF1 signaling|GFs/TNF -> ion channels|HGFR -> AP-1/CREB/MYC signaling|IGF1R -> MEF/MYOD/MYOG signaling|IL1R -> NF-kB signaling|IL1R -> STAT3 signaling|KIT -> MITF signaling|NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling|Natural Killer Cell Activation|Natural Killer Cell Activation through C-type Lectin-like Receptors|Natural Killer Cell Activation through ITAM-Containing Receptors|Natural Killer Cell Activation through ITSM-Containing Receptors|Natural Killer Cell Activation through Integrins and non-ITAM-Containing Receptors|Natural Killer Cell Inhibitory Receptor Signaling|Nociception-related DRD2 expression targets|Nociception-related IL1B expression targets|PDGFR -> AP-1/MYC signaling|T-cell receptor -> ATF/CREB signaling|T-cell-Dependent B-cell Activation|T-cell-Independent B-cell Activation|TLR1/2/6 -> NF-kB signaling|ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling|ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling|Tight Junction Assembly (Claudins)|Tight Junction Assembly (JAMs)|Toll-like Receptors Act through MYD88-TIRAP Signaling|VEGFR -> AP-1/CREB/MYC signaling|VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling|VasopressinR1 -> MEF/MYOD/NFATC/MYOG signaling|VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling|VasopressinR2 -> MEF/MYOD/NFATC/MYOG signaling"	""	""	"Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3."	""	"FALSE"
"2871-73_2"	"SL006922"	"RAD51"	"DNA repair protein RAD51 homolog 1"	"15"	"40694774"	"40732339"	"RAD51"	"5888"	"Q06609"	"DNA damage response|Homologous recombination|Integrated Breast Cancer Pathway|miRNA regulation of DNA Damage Response"	"ATR signaling pathway|BARD1 signaling events|p73 transcription factor network"	""	"Assembly of the RAD51-ssDNA nucleoprotein complex|Meiotic recombination|Presynaptic phase of homologous DNA pairing and strand exchange"	"Double Strand DNA Homologous Repair"	""	"efficacy|response to therapy"	"Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3."	""	"TRUE"
"2875-15_2"	"SL006923"	"TBP"	"TATA-box-binding protein"	"6"	"170554302"	"170572870"	"TBP"	"6908"	"P20226"	"Eukaryotic Transcription Initiation"	"Glucocorticoid receptor regulatory network|Regulation of retinoblastoma protein|Validated targets of C-MYC transcriptional repression"	""	"HIV Transcription Initiation|NoRC negatively regulates rRNA expression|RNA Polymerase I Chain Elongation|RNA Polymerase I Promoter Escape|RNA Polymerase I Transcription Initiation|RNA Polymerase I Transcription Termination|RNA Polymerase II HIV Promoter Escape|RNA Polymerase II Pre-transcription Events|RNA Polymerase II Promoter Escape|RNA Polymerase II Transcription Initiation|RNA Polymerase II Transcription Initiation And Promoter Clearance|RNA Polymerase II Transcription Pre-Initiation And Promoter Opening|RNA Polymerase III Abortive And Retractive Initiation|RNA Polymerase III Transcription Initiation From Type 1 Promoter|RNA Polymerase III Transcription Initiation From Type 2 Promoter|RNA Polymerase III Transcription Initiation From Type 3 Promoter|SIRT1 negatively regulates rRNA Expression|Transcription of the HIV genome"	"Cell Cycle|mRNA Transcription and Processing|rRNA Transcription and Processing|tRNA Transcription and Processing"	""	""	"General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA."	""	"TRUE"
"2876-74_2"	"SL004305"	"Topoisomerase I"	"DNA topoisomerase 1"	"20"	"41028818"	"41124487"	"TOP1"	"7150"	"P11387"	""	"Caspase Cascade in Apoptosis"	""	""	"rRNA Transcription and Processing|tRNA Transcription and Processing"	"elsamitrucin|T 0128|polyglutamate camptothecin|elomotecan|tafluposide|cetuximab/irinotecan|capecitabine/irinotecan|5-fluorouracil/irinotecan|cisplatin/topotecan|cyclophosphamide/topotecan|cyclophosphamide/topotecan/vincristine|irinotecan/temozolomide|irinotecan/vincristine|cyclophosphamide/irinotecan/temozolomide|irinotecan/temozolomide/vincristine|bevacizumab/irinotecan|bevacizumab/irinotecan/oxaliplatin|aflibercept/irinotecan|irinotecan/oxaliplatin|cyclophosphamide/temozolomide/topotecan|docetaxel/irinotecan|capecitabine/irinotecan/oxaliplatin|bevacizumab/capecitabine/irinotecan/oxaliplatin|ifosfamide/topotecan|5-fluorouracil/irinotecan/oxaliplatin|gemcitabine/irinotecan|bevacizumab/paclitaxel/topotecan|paclitaxel/topotecan|cytarabine/topotecan|TAS-103|beta-lapachone|irinotecan|SN-38|topotecan|IDEC-132|stibogluconic acid|rubitecan|gimatecan|karenitecin"	"efficacy"	"Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Involved in the circadian transcription of the core circadian clock component ARNTL/BMAL1 by altering the chromatin structure around the ROR response elements (ROREs) on the ARNTL/BMAL1 promoter."	""	"TRUE"
"2877-3_1"	"SL004306"	"UBC9"	"SUMO-conjugating enzyme UBC9"	"16"	"1308880"	"1327018"	"UBE2I"	"7329"	"P63279"	"Androgen receptor signaling pathway|TGF beta Signaling Pathway"	"C-MYB transcription factor network|Coregulation of Androgen receptor activity|Regulation of cytoplasmic and nuclear SMAD2/3 signaling|Signaling events mediated by HDAC Class I|Signaling events mediated by HDAC Class II|Sumoylation by RanBP2 regulates transcriptional repression"	"protein sumoylation"	"Meiotic synapsis|SUMO is transferred from E1 to E2 (UBE2I, UBC9)|SUMOylation of DNA damage response and repair proteins"	"Histone Sumoylation"	""	"disease progression"	"Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'."	""	"TRUE"
"2878-66_2"	"SL006372"	"YES"	"Tyrosine-protein kinase Yes"	"18"	"721588"	"812546"	"YES1"	"7525"	"P07947"	""	"Alpha-synuclein signaling|CDC42 signaling events|CXCR4-mediated signaling events|Class I PI3K signaling events|EPHA forward signaling|Ephrin B reverse signaling|Glypican 1 network|Netrin-mediated signaling events|Noncanonical Wnt signaling pathway|PDGFR-beta signaling pathway|Regulation of p38-alpha and p38-beta|Signaling events mediated by PTP1B|Signaling events mediated by focal adhesion kinase|Thromboxane A2 receptor signaling|amb2 Integrin signaling"	""	"CD28 co-stimulation|CTLA4 inhibitory signaling|EPH-Ephrin signaling|EPH-ephrin mediated repulsion of cells|EPHA-mediated growth cone collapse|EPHB-mediated forward signaling|FCGR activation|PECAM1 interactions|Regulation of KIT signaling|Regulation of signaling by CBL|Signaling by ERBB2|Signaling by SCF-KIT"	"Adherens Junction Assembly (Cadherins)"	"dasatinib|dasatinib/dexamethasone/vincristine"	""	"Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis."	""	"TRUE"
"2879-9_2"	"SL000248"	"a1-Antichymotrypsin"	"Alpha-1-antichymotrypsin"	"14"	"94592058"	"94624646"	"SERPINA3"	"12"	"P01011"	"Folate Metabolism|Selenium Pathway|Vitamin B12 Metabolism"	""	""	""	""	""	"unspecified application"	"Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2."	"270"	"TRUE"
"2888-49_2"	"SL000323"	"C7"	"Complement component C7"	"5"	"40909252"	"40982939"	"C7"	"730"	"P10643"	"Complement Activation, Classical Pathway|Complement and Coagulation Cascades"	""	""	"Regulation of Complement cascade|Terminal pathway of complement"	"Alternative Complement Pathway|Classical Complement Pathway|Lectin-Induced Complement Pathway"	""	""	"Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor."	"229|246|314|393"	"TRUE"
"2889-37_2"	"SL002783"	"Cardiotrophin-1"	"Cardiotrophin-1"	"16"	"30896607"	"30903560"	"CTF1"	"1489"	"Q16619"	"MicroRNAs in cardiomyocyte hypertrophy|Physiological and Pathological Hypertrophy  of the Heart"	""	""	""	"LIFR -> STAT5A signaling"	""	""	"Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor."	""	"TRUE"
"2890-59_2"	"SL003303"	"CCL28"	"C-C motif chemokine 28"	"5"	"43376645"	"43412391"	"CCL28"	"56477"	"Q9NRJ3"	""	""	""	"Chemokine receptors bind chemokines|G alpha (i) signalling events"	""	""	""	"Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner."	""	"TRUE"
"2891-1_3"	"SL004330"	"CD22"	"B-cell receptor CD22"	"19"	"35319261"	"35347355"	"CD22"	"933"	"P20273"	"B Cell Receptor Signaling Pathway"	"BCR signaling pathway"	""	""	"T-cell receptor -> AP-1 signaling|T-cell receptor -> ATF/CREB signaling|T-cell receptor -> CREBBP signaling|T-cell receptor -> NF-kB signaling|T-cell receptor -> NFATC signaling|T-cell receptor -> STAT signaling|T-cell-Dependent B-cell Activation"	"epratuzumab|BL22 immunotoxin|inotuzumab ozogamicin|combotox|RFB4-dgRTA"	""	"Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules."	""	"TRUE"
"2900-53_3"	"SL003329"	"HCC-1"	"C-C motif chemokine 14"	"17"	"35983291"	"35987004"	"CCL14"	"6358"	"Q16627"	""	""	""	""	"CCR1 -> STAT signaling|CCR2/5 -> STAT signaling|CCR5 -> TP53 signaling|Nociception-related CCR1 expression targets|Summarized nociception-related expression targets"	""	""	"Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induced intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and was inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5."	"33|88|92|216|373"	"TRUE"
"2906-55_3"	"SL000480"	"IL-4"	"Interleukin-4"	"5"	"132673986"	"132682676"	"IL4"	"3565"	"P05112"	"Cytokines and Inflammatory Response|Folate Metabolism|IL-4 signaling pathway|Inflammatory Response Pathway|Th1/Th2"	"AP-1 transcription factor network|CD40/CD40L signaling|Calcineurin-regulated NFAT-dependent transcription in lymphocytes|Calcium signaling in the CD4+ TCR pathway|Glucocorticoid receptor regulatory network|IL12-mediated signaling events|IL2 signaling events mediated by STAT5|IL4-mediated signaling events|Notch signaling pathway"	""	""	"Activation of Immunoglobulin Class-Switch Recombination|CD8+ T-cell Activation|CNR1/2 -> IL1B/2/4/6/10 production|IL4R -> ELK-SRF/HMGY signaling|IL4R -> STAT signaling|Model of T-cell Maturation|Summarized nociception-related expression targets|T-cell Receptor Signaling|T-cell-Dependent B-cell Activation|Th2 Cell Differentiation"	""	"diagnosis|disease progression|efficacy|prognosis|response to therapy|unspecified application"	"Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes."	""	"TRUE"
"2911-27_2"	"SL002621"	"Midkine"	"Midkine"	"11"	"46380756"	"46383837"	"MDK"	"4192"	"P21741"	""	"Alpha4 beta1 integrin signaling events|Beta1 integrin cell surface interactions|Glypican 2 network|Syndecan-4-mediated signaling events"	""	"NOTCH2 Activation and Transmission of Signal to the Nucleus"	"ALK -> STAT signaling|MDK/PTN Expression Targets"	""	""	"Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity)."	""	"TRUE"
"2913-1_2"	"SL003302"	"MPIF-1"	"C-C motif chemokine 23"	"17"	"36013056"	"36017968"	"CCL23"	"6368"	"P55773"	""	""	""	"Formyl peptide receptors bind formyl peptides and many other ligands|G alpha (i) signalling events|G alpha (q) signalling events"	"CCR1 -> STAT signaling|Nociception-related CCR1 expression targets|Summarized nociception-related expression targets"	""	""	"Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23."	"88"	"TRUE"
"2915-6_2"	"SL000131"	"PCNA"	"Proliferating cell nuclear antigen"	"20"	"5114953"	"5126626"	"PCNA"	"5111"	"P12004"	"Cell cycle|DNA Replication|EGF/EGFR Signaling Pathway|G1 to S cell cycle control|Mismatch repair|Nifedipine Activity"	"BARD1 signaling events|Direct p53 effectors|Validated nuclear estrogen receptor alpha network"	""	"E2F mediated regulation of DNA replication|G0 and Early G1|G1/S-Specific Transcription|Leading Strand Synthesis|Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)|Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)|PCNA-Dependent Long Patch Base Excision Repair|Polymerase switching|Polymerase switching on the C-strand of the telomere|Processive synthesis on the C-strand of the telomere|Processive synthesis on the lagging strand|Recognition of DNA damage by PCNA-containing replication complex|Removal of the Flap Intermediate|Removal of the Flap Intermediate from the C-strand|Repair synthesis for gap-filling by DNA polymerase in TC-NER|Repair synthesis of patch ~27-30 bases long by DNA polymerase|Telomere C-strand (Lagging Strand) Synthesis|Termination of translesion DNA synthesis|Translesion Synthesis by POLH|Translesion synthesis by POLI|Translesion synthesis by POLK|Translesion synthesis by REV1"	"DNA Replication|Histone and DNA Methylation|Single-Strand Base Excision DNA Repair|Single-Strand Mismatch DNA Repair|Single-Strand Nucleotide Excision DNA Repair|Sister Chromatid Cohesion"	""	"efficacy|prognosis|response to therapy"	"Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion."	""	"TRUE"
"2917-3_2"	"SL002541"	"sRANKL"	"Tumor necrosis factor ligand superfamily member 11"	"13"	"42562736"	"42608013"	"TNFSF11"	"8600"	"O14788"	"Osteoblast Signaling|Osteoclast Signaling|RANKL/RANK Signaling Pathway"	"IL6-mediated signaling events"	""	""	""	"lenalidomide|denosumab|lenalidomide/temsirolimus|dexamethasone/lenalidomide/sorafenib|dexamethasone/lenalidomide|bortezomib/dexamethasone/lenalidomide|carfilzomib/dexamethasone/lenalidomide|lenalidomide/rituximab|denosumab/levothyroxine|erythropoietin/lenalidomide"	"efficacy"	"Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy."	""	"TRUE"
"2925-9_1"	"SL000006"	"PAI-1"	"Plasminogen activator inhibitor 1"	"7"	"101127089"	"101139266"	"SERPINE1"	"5054"	"P05121"	"Adipogenesis|Blood Clotting Cascade|Complement and Coagulation Cascades|Folate Metabolism|Selenium Pathway|Senescence and Autophagy|TGF Beta Signaling Pathway|Vitamin B12 Metabolism"	"Direct p53 effectors|E2F transcription factor network|HIF-1-alpha transcription factor network|HIF-2-alpha transcription factor network|Regulation of nuclear SMAD2/3 signaling|Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling|p73 transcription factor network"	""	"BMAL1:CLOCK,NPAS2 activates circadian gene expression|Dissolution of Fibrin Clot|ECM proteoglycans|Platelet degranulation|SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"	""	"drotrecogin alfa"	"diagnosis|disease progression|efficacy|prognosis|safety"	"Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis."	""	"TRUE"
"2937-10_2"	"SL004668"	"Apo E3"	"Apolipoprotein E (isoform E3)"	"19"	"44905754"	"44909393"	"APOE"	"348"	"P02649"	"Alzheimers Disease|Statin Pathway|Vitamin B12 Metabolism"	""	""	"Chylomicron-mediated lipid transport|HDL-mediated lipid transport|Retinoid metabolism and transport|Scavenging by Class A Receptors"	""	""	"diagnosis|efficacy|prognosis|unspecified application"	"Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues."	""	"TRUE"
"2938-55_2"	"SL004669"	"Apo E4"	"Apolipoprotein E (isoform E4)"	"19"	"44905754"	"44909393"	"APOE"	"348"	"P02649"	"Alzheimers Disease|Statin Pathway|Vitamin B12 Metabolism"	""	""	"Chylomicron-mediated lipid transport|HDL-mediated lipid transport|Retinoid metabolism and transport|Scavenging by Class A Receptors"	""	""	"diagnosis|efficacy|prognosis|unspecified application"	"Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues."	""	"TRUE"
"2939-10_2"	"SL004670"	"Artemin"	"Artemin"	"1"	"43933320"	"43937241"	"ARTN"	"9048"	"Q5T4W7"	""	""	""	"NCAM1 interactions"	"GDNF -> HSF1 signaling|GFs/TNF -> ion channels|Regulation of calcium flux"	""	""	"Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue."	""	"TRUE"
"2942-50_2"	"SL000396"	"Cytochrome c"	"Cytochrome c"	"7"	"25120091"	"25125361"	"CYCS"	"54205"	"P99999"	"Alzheimers Disease|Apoptosis|Apoptosis Modulation and Signaling|Apoptosis Modulation by HSP70|DNA damage response|FAS pathway and Stress induction of HSP regulation|miRNA regulation of DNA Damage Response"	"Caspase Cascade in Apoptosis|Ceramide signaling pathway|HIV-1 Nef: Negative effector of Fas and TNF-alpha|mTOR signaling pathway|p75(NTR)-mediated signaling"	""	"Activation of caspases through apoptosome-mediated cleavage|Detoxification of Reactive Oxygen Species|Formation of apoptosome|Release of apoptotic factors from the mitochondria|Respiratory electron transport|TP53 Regulates Metabolic Genes|Transcriptional activation of mitochondrial biogenesis"	"Apoptosis|Cell Death Mediated by Cytotoxic Cells|Heme biosynthesis|Pyruvate metabolism|Respiratory chain and oxidative phosphorylation"	""	""	"Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain."	""	"TRUE"
"2943-5_2"	"SL000398"	"Cytochrome P450 3A4"	"Cytochrome P450 3A4"	"7"	"99756960"	"99784265"	"CYP3A4"	"1576"	"P08684"	"Aflatoxin B1 metabolism|Benzo(a)pyrene metabolism|Codeine and morphine metabolism|Estrogen metabolism|Fatty Acid Omega Oxidation|Irinotecan Pathway|Nifedipine Activity|Nuclear receptors in lipid metabolism and toxicity|Tamoxifen metabolism|Tryptophan metabolism|cytochrome P450|metapathway biotransformation"	""	""	"Aflatoxin activation and detoxification|Xenobiotics"	"Vitamin A (retinol) metabolism and visual cycle"	"cobicistat|cobicistat/elvitegravir/emtricitabine/tenofovir disoproxil|atazanavir/cobicistat|cobicistat/darunavir|ketoconazole"	"diagnosis|efficacy|safety"	"Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide (PubMed:11159812). Catalyzes 4-beta-hydroxylation of cholesterol. May catalyze 25-hydroxylation of cholesterol in vitro (PubMed:21576599)."	""	"TRUE"
"2944-66_2"	"SL005156"	"DAN"	"Neuroblastoma suppressor of tumorigenicity 1"	"1"	"19596979"	"19658456"	"NBL1"	"4681"	"P41271"	""	""	""	""	""	""	""	"Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process."	""	"TRUE"
"2945-25_1"	"SL000007"	"ER"	"Estrogen receptor"	"6"	"151656691"	"152129619"	"ESR1"	"2099"	"P03372"	"Estrogen signaling pathway|Integrated Breast Cancer Pathway|Leptin signaling pathway|Muscle cell TarBase|Nuclear Receptors"	"AP-1 transcription factor network|ATF-2 transcription factor network|FOXA1 transcription factor network|FOXM1 transcription factor network|LKB1 signaling events|Plasma membrane estrogen receptor signaling|Regulation of Telomerase|Regulation of nuclear SMAD2/3 signaling|Signaling events mediated by HDAC Class II|Signaling mediated by p38-alpha and p38-beta|Validated nuclear estrogen receptor alpha network"	""	"Nuclear Receptor transcription pathway|Nuclear signaling by ERBB4"	""	"17-alpha-ethinylestradiol|fulvestrant|beta-estradiol|estradiol 17beta-cypionate|estriol|estrone|estradiol valerate|mestranol|CHF-4227|bazedoxifene|estradiol valerate/testosterone enanthate|TAS-108|ethinyl estradiol/ethynodiol diacetate|estradiol acetate|esterified estrogens|estradiol cypionate/medroxyprogesterone acetate|estradiol/norethindrone acetate|synthetic conjugated estrogens|A|estradiol cypionate/testosterone cypionate|B|etonogestrel|CC8490|MITO-4509|cyproterone acetate/ethinyl estradiol|ethinyl estradiol/etonogestrel|chlorotrianisene|megestrol acetate/tamoxifen|sulindac/tamoxifen|sulindac/toremifene|raloxifene/sulindac|ethynodiol|goserelin/tamoxifen|raloxifene/teriparatide|desogestrel/ethinyl estradiol|drospirenone/ethinyl estradiol|premarin|ethinyl estradiol/norelgestromin|ethinyl estradiol/norethindrone|ethinyl estradiol/levonorgestrel|ethinyl estradiol/norgestrel|ethinyl estradiol/norgestimate|conjugated estrogen/medroxyprogesterone acetate|diethylstilbestrol|ospemifene|toremifene|tamoxifen|raloxifene|arzoxifene|clomiphene|estramustine phosphate|diethylstilbestrol diphosphate|estropipate|dienestrol|estramustine|medroxyprogesterone acetate|desogestrel|danazol|trilostane|fluoxymesterone|norgestimate|progesterone"	"diagnosis|disease progression|efficacy|prognosis|response to therapy"	"Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full length receptor. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3. Isoform 3 can bind to ERE and inhibit isoform 1."	"43"	"TRUE"
"2946-52_2"	"SL003327"	"Factor D"	"Complement factor D"	"19"	"859643"	"863642"	"CFD"	"1675"	"P00746"	"Adipogenesis"	""	""	"Alternative complement activation|Platelet degranulation"	"Alternative Complement Pathway"	""	""	"Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway."	""	"TRUE"
"2948-58_2"	"SL005168"	"Growth hormone receptor"	"Growth hormone receptor"	"5"	"42423777"	"42721878"	"GHR"	"2690"	"P10912"	"Endochondral Ossification"	"Notch-mediated HES/HEY network"	""	"Growth hormone receptor signaling|Prolactin receptor signaling"	"GHR -> ELK-SRF/MYC signaling|GHR -> NF-kB signaling|GHR -> STAT signaling"	"GH1|prednisone/somatotropin|pegvisomant|somatrem"	""	"Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity)."	""	"TRUE"
"2949-6_2"	"SL004067"	"GX"	"Group 10 secretory phospholipase A2"	"16"	"14672545"	"14694674"	"PLA2G10"	"8399"	"O15496"	"MAPK signaling pathway"	""	""	"Acyl chain remodelling of PC|Acyl chain remodelling of PE|Acyl chain remodelling of PG|Acyl chain remodelling of PI|Acyl chain remodelling of PS|Synthesis of PA"	""	"varespladib methyl|varespladib"	""	"PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine."	""	"TRUE"
"2950-57_2"	"SL005171"	"IGFBP-4"	"Insulin-like growth factor-binding protein 4"	"17"	"40443461"	"40457731"	"IGFBP4"	"3487"	"P22692"	"Myometrial Relaxation and Contraction Pathways"	"Wnt signaling network"	""	"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"	""	""	""	"IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors."	""	"TRUE"
"2952-75_2"	"SL000047"	"IGF-I"	"Insulin-like growth factor I"	"12"	"102395867"	"102480645"	"IGF1"	"3479"	"P05019"	"Adipogenesis|Apoptosis|Endochondral Ossification|Focal Adhesion|MicroRNAs in cardiomyocyte hypertrophy|Senescence and Autophagy|TarBasePathway"	""	""	"IRS-related events triggered by IGF1R|Platelet degranulation|Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)|SHC-related events triggered by IGF1R|Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)|Synthesis, secretion, and deacylation of Ghrelin"	"IGF1R -> CEBPA/FOXO1A signaling|IGF1R -> ELK-SRF/HIF1A/MYC/SREBF signaling|IGF1R -> MEF/MYOD/MYOG signaling|IGF1R -> STAT signaling"	""	"diagnosis|efficacy|prognosis|safety"	"The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (PubMed:21076856, PubMed:24132240). Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb (By similarity)."	"178"	"TRUE"
"2953-31_2"	"SL000506"	"Luteinizing hormone"	"Luteinizing hormone"	"19|6"	"49015980|87085498"	"49017090|87095406"	"CGA|LHB"	"1081|3972"	"P01215|P01229"	"FSH signaling pathway|TSH signaling pathway"	"Glucocorticoid receptor regulatory network"	""	"Androgen biosynthesis|G alpha (s) signalling events|Glycoprotein hormones|Hormone ligand-binding receptors|Mineralocorticoid biosynthesis|Thyroxine biosynthesis"	""	""	""	"Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.|Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids."	""	"TRUE"
"2954-56_2"	"SL000526"	"MMP-8"	"Neutrophil collagenase"	"11"	"102711795"	"102727050"	"MMP8"	"4317"	"P22894"	"NA"	"NA"	"NA"	"NA"	"NA"	"marimastat"	"efficacy"	"Can degrade fibrillar type I, II, and III collagens."	"123|132|350|426"	"TRUE"
"2957-21_2"	"SL003542"	"NG36"	"Histone-lysine N-methyltransferase EHMT2"	"6"	"31861940"	"31974166"	"EHMT2"	"10919"	"Q96KQ7"	"NA"	"NA"	"NA"	"NA"	"NA"	""	""	"Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself."	""	"TRUE"
"2960-66_2"	"SL003192"	"Properdin"	"Properdin"	"X"	"47624213"	"47630305"	"CFP"	"5199"	"P27918"	""	""	""	"Activation of C3 and C5|Alternative complement activation|O-glycosylation of TSR domain-containing proteins|Regulation of Complement cascade"	"Alternative Complement Pathway"	""	""	"A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes."	"177"	"TRUE"
"2961-1_2"	"SL000048"	"Protein C"	"Vitamin K-dependent protein C"	"2"	"127418427"	"127429246"	"PROC"	"5624"	"P04070"	"Complement and Coagulation Cascades"	"Beta2 integrin cell surface interactions"	""	"Cell surface interactions at the vascular wall|Common Pathway of Fibrin Clot Formation|Gamma-carboxylation of protein precursors|Intrinsic Pathway of Fibrin Clot Formation|Removal of aminoterminal propeptides from gamma-carboxylated proteins|Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus"	"Coagulation Cascade|Vitamin K metabolism"	""	"diagnosis|efficacy"	"Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265). Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845)."	"106"	"TRUE"
"2962-50_2"	"SL002561"	"PTHrP"	"Parathyroid hormone-related protein"	"12"	"27958084"	"27972705"	"PTHLH"	"5744"	"P12272"	"Endochondral Ossification"	"Signaling events mediated by the Hedgehog family"	""	"Class B/2 (Secretin family receptors)|G alpha (s) signalling events"	"Nociception-related IL1B expression targets"	""	""	"Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1."	""	"TRUE"
"2966-65_2"	"SL004362"	"SCGF-beta"	"Stem Cell Growth Factor-beta"	"19"	"50723329"	"50725718"	"CLEC11A"	"6320"	"Q9Y240"	""	""	""	""	""	""	""	"Stimulates the proliferation and differentiation of hematopoietic precursor cells from various lineages, including erythrocytes, lymphocytes, granulocytes and macrophages. Acts synergistically with other cytokines, including IL-3, GCSF, GMCSF and FLT3 ligand. Suppresses SCF-stimulated erythrocyte proliferation."	""	"TRUE"
"2967-8_1"	"SL001720"	"VCAM-1"	"Vascular cell adhesion protein 1"	"1"	"100719742"	"100739045"	"VCAM1"	"7412"	"P19320"	"Lymphocyte TarBase|RANKL/RANK Signaling Pathway|Squamous cell  TarBase"	"Alpha4 beta1 integrin signaling events|Alpha9 beta1 integrin signaling events|Beta1 integrin cell surface interactions|Beta2 integrin cell surface interactions|Beta5 beta6 beta7 and beta8 integrin cell surface interactions|Cellular roles of Anthrax toxin|Thromboxane A2 receptor signaling|a4b7 Integrin signaling"	""	"Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell|Integrin cell surface interactions|Interferon gamma signaling"	"Leukocyte Adhesion to Endothelial Cell|Natural Killer Cell Activation through Integrins and non-ITAM-Containing Receptors"	""	"diagnosis|disease progression|efficacy|prognosis|unspecified application"	"Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation."	""	"TRUE"
"2968-61_1"	"SL004686"	"TNFSF15"	"Tumor necrosis factor ligand superfamily member 15"	"9"	"114784635"	"114806126"	"TNFSF15"	"9966"	"O95150"	"Senescence and Autophagy"	""	""	""	"Apoptosis|Peripheral T-cell Tolerance Overview"	""	""	"Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis."	""	"TRUE"
"2969-11_1"	"SL004851"	"ALK-1"	"Serine/threonine-protein kinase receptor R3"	"12"	"51906908"	"51923361"	"ACVRL1"	"94"	"P37023"	""	"ALK1 pathway|ALK1 signaling events"	""	""	"TGFBR -> SMAD1/5/9 signaling"	""	"diagnosis"	"Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well."	""	"TRUE"
"2970-60_2"	"SL000136"	"AREG"	"Amphiregulin"	"4"	"74445134"	"74455009"	"AREG"	"374"	"P15514"	"ErbB signaling pathway|FSH signaling pathway"	"ErbB receptor signaling network"	""	""	""	""	"diagnosis|efficacy|prognosis|response to therapy"	"Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts."	""	"TRUE"
"2972-57_2"	"SL004078"	"BMP-7"	"Bone morphogenetic protein 7"	"20"	"57168748"	"57266629"	"BMP7"	"655"	"P18075"	"Endochondral Ossification|Neural Crest Differentiation"	"ALK2 signaling events|BMP receptor signaling"	""	"Molecules associated with elastic fibres"	"ActivinR -> SMAD2/3 signaling|ActivinR/BMPR -> SMAD1/5/9 signaling"	""	"diagnosis"	"Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis."	""	"TRUE"
"2973-15_2"	"SL000668"	"CD36 ANTIGEN"	"Platelet glycoprotein 4"	"7"	"80369575"	"80679277"	"CD36"	"948"	"P16671"	"Vitamin A and carotenoid metabolism"	""	""	"Cross-presentation of particulate exogenous antigens (phagosomes)|IRAK4 deficiency (TLR2/4)|MyD88 deficiency (TLR2/4)|MyD88:Mal cascade initiated on plasma membrane|PPARA activates gene expression|Platelet degranulation|Scavenging by Class B Receptors|Toll Like Receptor TLR6:TLR2 Cascade|Transcriptional regulation of white adipocyte differentiation"	""	""	"efficacy"	"Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (Probable). Binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption (By similarity) (PubMed:18353783, PubMed:21610069). In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway (By similarity) (PubMed:18753675). Involved in oral fat perception and preferences (PubMed:22240721, PubMed:25822988). Detection into the tongue of long-chain fatty acids leads to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions (By similarity). In taste receptor cells, mediates the induction of an increase in intracellulare calcium levels by long-chain fatty acids, leading to the activation of the gustatory neurons in the nucleus of the solitary tract (By similarity). Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the regulation of energy and glucose homeostasis (By similarity). Receptor for thombospondins, THBS1 and THBS2, mediating their antiangiogenic effects (By similarity). As a coreceptor for TLR4:TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, interacts with the heterodimer TLR4:TLR6, the complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion, through the priming and activation of the NLRP3 inflammasome (By similarity) (PubMed:20037584). Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2:TLR6 heterodimer, this cluster triggers signaling from the cell surface, leading to the NF-kappa-B-dependent production of TNF, via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (By similarity) (PubMed:16880211)."	"28"	"TRUE"
"2974-61_2"	"SL004855"	"contactin-1"	"Contactin-1"	"12"	"40692442"	"41072418"	"CNTN1"	"1272"	"Q12860"	""	"Notch signaling pathway"	""	"Activated NOTCH1 Transmits Signal to the Nucleus|L1CAM interactions|NOTCH2 Activation and Transmission of Signal to the Nucleus|Neurofascin interactions"	""	""	""	"Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity)."	""	"TRUE"
"2975-19_2"	"SL002655"	"CTGF"	"Connective tissue growth factor"	"6"	"131948176"	"131951373"	"CTGF"	"1490"	"P29279"	""	"TGF-beta receptor signaling|amb2 Integrin signaling"	""	"PPARA activates gene expression|YAP1- and WWTR1 (TAZ)-stimulated gene expression"	""	""	""	"Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis."	""	"TRUE"
"2976-58_2"	"SL004856"	"Desmoglein-1"	"Desmoglein-1"	"18"	"31318089"	"31357029"	"DSG1"	"1828"	"Q02413"	""	""	""	"Apoptotic cleavage of cell adhesion proteins"	"Desmosome Assembly"	""	""	"Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion."	""	"TRUE"
"2977-7_2"	"SL004872"	"EDAR"	"Tumor necrosis factor receptor superfamily member EDAR"	"2"	"108894471"	"108989372"	"EDAR"	"10913"	"Q9UNE0"	"Integrated Breast Cancer Pathway"	""	""	""	"Apoptosis|EctodysplasinR -> AP-1 signaling|EctodysplasinR -> LEF1 signaling|EctodysplasinR -> NF-kB signaling"	""	""	"Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death."	"217|234|417"	"TRUE"
"2979-8_2"	"SL003169"	"ENA-78"	"C-X-C motif chemokine 5"	"4"	"73995642"	"73998779"	"CXCL5"	"6374"	"P42830"	""	""	""	"Chemokine receptors bind chemokines|G alpha (i) signalling events"	"IL8R -> CREB/EGR signaling"	""	""	"Involved in neutrophil activation. In vitro, ENA-78(8-78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes."	""	"TRUE"
"2981-9_3"	"SL005160"	"ESAM"	"Endothelial cell-selective adhesion molecule"	"11"	"124752583"	"124762290"	"ESAM"	"90952"	"Q96AP7"	""	""	""	"Cell surface interactions at the vascular wall"	""	""	""	"Can mediate aggregation most likely through a homophilic molecular interaction."	"406"	"TRUE"
"2982-82_2"	"SL005165"	"Galectin-4"	"Galectin-4"	"19"	"38801671"	"38813364"	"LGALS4"	"3960"	"P56470"	""	""	""	""	""	""	"diagnosis"	"Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions."	""	"TRUE"
"2985-35_1"	"SL003173"	"Gro-a"	"Growth-regulated alpha protein"	"4"	"73869393"	"73871242"	"CXCL1"	"2919"	"P09341"	"Cytokines and Inflammatory Response|Senescence and Autophagy"	"IL23-mediated signaling events"	""	"Chemokine receptors bind chemokines|G alpha (i) signalling events"	"IL8R -> CREB/EGR signaling"	""	"disease progression"	"Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity."	"12|99"	"TRUE"
"2986-49_2"	"SL017610"	"Gro-b/g"	"Gro-beta/gamma"	"4"	"74036589"	"74099293"	"CXCL3|CXCL2"	"NA"	"P19876|P19875"	"Cytokines and Inflammatory Response"	""	""	"Chemokine receptors bind chemokines|G alpha (i) signalling events"	"IL8R -> CREB/EGR signaling"	""	""	"Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.|Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity."	""	"TRUE"
"2987-37_3"	"SL005256"	"Histone H1.2"	"Histone H1.2"	"6"	"26055787"	"26056428"	"HIST1H1C"	"3006"	"P16403"	""	""	""	"Activation of DNA fragmentation factor|Formation of Senescence-Associated Heterochromatin Foci (SAHF)"	""	""	""	"Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity)."	""	"TRUE"
"2989-17_2"	"SL001802"	"IFN-g"	"Interferon gamma"	"12"	"68154768"	"68159747"	"IFNG"	"3458"	"P01579"	"NA"	"NA"	"NA"	"NA"	"NA"	""	"diagnosis|efficacy|response to therapy|unspecified application"	"Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons."	""	"TRUE"
"2991-9_2"	"SL001997"	"IL-1 sRI"	"Interleukin-1 receptor type 1"	"2"	"102064544"	"102179874"	"IL1R1"	"3554"	"P14778"	"Apoptosis Modulation and Signaling|Hypertrophy Model|IL-1 signaling pathway|MAPK signaling pathway|Monoamine Transport"	"IL1-mediated signaling events|IL12-mediated signaling events"	""	"Interleukin-1 signaling"	"IL1R -> NF-kB signaling|IL1R -> STAT3 signaling|Nociception-related IL1B expression targets|Th17 Cell Differentiation"	"anakinra"	""	"Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex."	""	"TRUE"
"2992-59_2"	"SL004850"	"IL-17 sR"	"Interleukin-17 receptor A"	"22"	"17084954"	"17115694"	"IL17RA"	"23765"	"Q96F46"	""	""	""	""	""	""	""	"Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:19838198, PubMed:17911633). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (PubMed:16785495, PubMed:17911633, PubMed:18684971)."	"32|421"	"TRUE"
"2993-1_2"	"SL004861"	"IL-18 Rb"	"Interleukin-18 receptor accessory protein"	"2"	"102418689"	"102452565"	"IL18RAP"	"8807"	"O95256"	""	"IL12 signaling mediated by STAT4|IL12-mediated signaling events|IL23-mediated signaling events"	""	""	"Th1 Cell Differentiation"	""	""	"Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex (By similarity). Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK."	"168"	"TRUE"
"2994-71_2"	"SL004875"	"IL-1Rrp2"	"Interleukin-1 receptor-like 2"	"2"	"102186973"	"102240002"	"IL1RL2"	"8808"	"Q9HB29"	""	""	""	""	""	""	""	"Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway."	"300|398"	"TRUE"
"2997-8_1"	"SL005193"	"JAM-B"	"Junctional adhesion molecule B"	"21"	"25639272"	"25717562"	"JAM2"	"58494"	"P57087"	""	"Alpha4 beta1 integrin signaling events|Beta1 integrin cell surface interactions|amb2 Integrin signaling"	""	"Cell surface interactions at the vascular wall|Integrin cell surface interactions"	"Leukocyte Adhesion to Endothelial Cell|Tight Junction Assembly (JAMs)"	""	""	"May play a role in the processes of lymphocyte homing to secondary lymphoid organs."	""	"TRUE"
"2998-53_2"	"SL005194"	"JAM-C"	"Junctional adhesion molecule C"	"11"	"134068925"	"134152001"	"JAM3"	"83700"	"Q9BX67"	""	"Beta2 integrin cell surface interactions|amb2 Integrin signaling"	""	"Cell surface interactions at the vascular wall|Integrin cell surface interactions"	"Leukocyte Adhesion to Endothelial Cell|Tight Junction Assembly (JAMs)"	""	""	"Participates in cell-cell adhesion. It is a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). The soluble form is a mediator of angiogenesis."	""	"TRUE"
"2999-6_2"	"SL005196"	"LSAMP"	"Limbic system-associated membrane protein"	"3"	"115802363"	"117139389"	"LSAMP"	"4045"	"Q13449"	""	""	""	""	""	""	""	"Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hyppocampal mossy fiber projection (By similarity)."	""	"TRUE"
"3000-66_1"	"SL004516"	"MBL"	"Mannose-binding protein C"	"10"	"52765380"	"52771700"	"MBL2"	"4153"	"P11226"	"Regulation of toll-like receptor signaling pathway"	""	""	"Initial triggering of complement|Lectin pathway of complement activation"	"Lectin-Induced Complement Pathway"	""	"diagnosis"	"Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA."	"34|36|194|257"	"TRUE"
"3003-29_2"	"SL005205"	"NKp30"	"Natural cytotoxicity triggering receptor 3"	"6"	"31571039"	"31669285"	"NCR3"	"259197"	"O14931"	""	""	""	""	"Natural Killer Cell Activation|Natural Killer Cell Activation through ITAM-Containing Receptors"	""	""	"Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation."	"174"	"TRUE"
"3004-67_2"	"SL004862"	"PD-L2"	"Programmed cell death 1 ligand 2"	"9"	"5510570"	"5571254"	"PDCD1LG2"	"80380"	"Q9BQ51"	""	""	""	"PD-1 signaling"	"Peripheral T-cell Tolerance Overview"	""	""	"Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity)."	"152"	"TRUE"
"3005-5_2"	"SL004939"	"PTP-1B"	"Tyrosine-protein phosphatase non-receptor type 1"	"20"	"50510321"	"50585241"	"PTPN1"	"5770"	"P18031"	"Insulin Signaling|Leptin signaling pathway|Prolactin Signaling Pathway"	"Calcineurin-regulated NFAT-dependent transcription in lymphocytes|EGF receptor (ErbB1) signaling pathway|IGF1 pathway|Insulin Pathway|N-cadherin signaling events|PDGFR-beta signaling pathway|Posttranslational regulation of adherens junction stability and dissassembly|Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)|Signaling events mediated by PTP1B|Signaling events mediated by TCPTP"	""	"Growth hormone receptor signaling|Integrin alphaIIb beta3 signaling|Regulation of IFNA signaling|Regulation of IFNG signaling"	"Adherens Junction Assembly (Cadherins)"	""	"prognosis"	"Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET."	""	"TRUE"
"3007-7_2"	"SL005219"	"Siglec-9"	"Sialic acid-binding Ig-like lectin 9"	"19"	"51124908"	"51136651"	"SIGLEC9"	"27180"	"Q9Y336"	""	""	""	""	"Natural Killer Cell Inhibitory Receptor Signaling"	""	""	"Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface."	"49|124|385|392"	"TRUE"
"3009-3_2"	"SL005059"	"TGF-b R III"	"Transforming growth factor beta receptor type 3"	"1"	"91680343"	"91906335"	"TGFBR3"	"7049"	"Q03167"	"TGF Beta Signaling Pathway|TGF beta Signaling Pathway"	"TGF-beta receptor signaling"	""	""	""	""	""	"Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors."	""	"TRUE"
"3010-53_2"	"SL004687"	"TSLP"	"Thymic stromal lymphopoietin"	"5"	"111070062"	"111078024"	"TSLP"	"85480"	"Q969D9"	""	""	""	""	""	""	""	"Isoform 1: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells."	""	"TRUE"
"3022-4_2"	"SL000384"	"CTLA-4"	"Cytotoxic T-lymphocyte protein 4"	"2"	"203867786"	"203873960"	"CTLA4"	"1493"	"P16410"	""	"Calcineurin-regulated NFAT-dependent transcription in lymphocytes"	""	"CTLA4 inhibitory signaling"	"Peripheral T-cell Tolerance Overview|Regulatory T-cell Differentiation|T-cell Receptor Signaling|T-cell receptor -> AP-1 signaling|T-cell receptor -> ATF/CREB signaling|T-cell receptor -> CREBBP signaling|T-cell receptor -> NF-kB signaling|T-cell receptor -> NFATC signaling|T-cell receptor -> STAT signaling"	"ipilimumab|ticilimumab"	"diagnosis|efficacy"	"Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28."	""	"TRUE"
"3024-18_2"	"SL000250"	"a2-Antiplasmin"	"Alpha-2-antiplasmin"	"17"	"1741760"	"1755268"	"SERPINF2"	"5345"	"P08697"	"Blood Clotting Cascade|Complement and Coagulation Cascades"	""	""	"Dissolution of Fibrin Clot|Platelet degranulation"	""	""	""	"Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin."	""	"TRUE"
"3025-50_1"	"SL000004"	"bFGF"	"Fibroblast growth factor 2"	"4"	"122826708"	"122898236"	"FGF2"	"2247"	"P09038"	"Angiogenesis|Endochondral Ossification|Lymphocyte TarBase|MicroRNAs in cardiomyocyte hypertrophy|Muscle cell TarBase|Neural Crest Differentiation|Regulation of Actin Cytoskeleton|Squamous cell  TarBase"	"Angiopoietin receptor Tie2-mediated signaling|FGF signaling pathway|Glypican 1 network|Integrins in angiogenesis|Syndecan-4-mediated signaling events"	""	"Activated point mutants of FGFR2|Constitutive Signaling by Aberrant PI3K in Cancer|FGFR1b ligand binding and activation|FGFR1c ligand binding and activation|FGFR2b ligand binding and activation|FGFR2c ligand binding and activation|FGFR3 mutant receptor activation|FGFR3c ligand binding and activation|FGFR4 ligand binding and activation|FRS-mediated FGFR1 signaling|FRS-mediated FGFR2 signaling|FRS-mediated FGFR3 signaling|FRS2-mediated FGFR4 signaling|Negative regulation of FGFR1 signaling|Negative regulation of FGFR2 signaling|Negative regulation of FGFR3 signaling|Negative regulation of FGFR4 signaling|Non-integrin membrane-ECM interactions|PI-3K cascade:FGFR1|PI-3K cascade:FGFR2|PI-3K cascade:FGFR3|PI-3K cascade:FGFR4|PI3K Cascade|PIP3 activates AKT signaling|POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation|Phospholipase C-mediated cascade, FGFR2|Phospholipase C-mediated cascade, FGFR3|Phospholipase C-mediated cascade, FGFR4|Phospholipase C-mediated cascade: FGFR1|SHC-mediated cascade:FGFR1|SHC-mediated cascade:FGFR2|SHC-mediated cascade:FGFR3|SHC-mediated cascade:FGFR4|Signaling by FGFR1 mutants|Signaling by FGFR2 mutants|Signaling by FGFR3 mutants|Signaling by FGFR4 mutants|Signaling by activated point mutants of FGFR1|Signaling by activated point mutants of FGFR3|Syndecan interactions"	"FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling|FGFR -> RUNX2 signaling|FGFR1 -> STAT signaling|FGFR3 -> STAT signaling|Nociception-related IL1B expression targets"	"pentosan polysulfate|suradista|sucralfate"	"diagnosis|efficacy|prognosis"	"Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro."	"103"	"TRUE"
"3026-5_2"	"SL000338"	"Calpastatin"	"Calpastatin"	"5"	"96525267"	"96779595"	"CAST"	"831"	"P20810"	""	""	""	""	""	""	""	"Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue."	"79"	"TRUE"
"3028-36_2"	"SL003301"	"Ck-b-8-1"	"Ck-beta-8-1"	"17"	"36013056"	"36017968"	"CCL23"	"6368"	"P55773"	""	""	""	"Formyl peptide receptors bind formyl peptides and many other ligands|G alpha (i) signalling events|G alpha (q) signalling events"	"CCR1 -> STAT signaling|Nociception-related CCR1 expression targets|Summarized nociception-related expression targets"	""	""	"Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23."	"202"	"TRUE"
"3029-52_2"	"SL005157"	"DC-SIGN"	"CD209 antigen"	"19"	"7739994"	"7747564"	"CD209"	"30835"	"Q9NNX6"	""	""	""	"CD209 (DC-SIGN) signaling"	"DC-SIGN (CD209) Signaling"	""	""	"Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response."	"36|349"	"TRUE"
"3030-3_2"	"SL005158"	"DC-SIGNR"	"C-type lectin domain family 4 member M"	"19"	"7763149"	"7769605"	"CLEC4M"	"10332"	"Q9H2X3"	""	""	""	""	""	""	""	"Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates."	""	"TRUE"
"3031-66_1"	"SL000420"	"Ferritin"	"Ferritin"	"11|19"	"61959718|48965301"	"61967660|48966878"	"FTH1|FTL"	"2495|2512"	"P02794|P02792"	"NA"	"NA"	"NA"	"NA"	"NA"	""	""	"Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).|Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity)."	"46|67"	"TRUE"
"3032-11_2"	"SL000428"	"FSH"	"Follicle stimulating hormone"	"11|6"	"30231016|87085498"	"30235261|87095406"	"CGA|FSHB"	"1081|2488"	"P01215|P01225"	"FSH signaling pathway"	""	""	"G alpha (s) signalling events|Glycoprotein hormones|Hormone ligand-binding receptors"	""	""	""	"Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.|Stimulates development of follicle and spermatogenesis in the reproductive organs."	""	"TRUE"
"3033-57_1"	"SL005164"	"Galectin-2"	"Galectin-2"	"22"	"37570246"	"37582616"	"LGALS2"	"3957"	"P05162"	""	""	""	""	""	""	""	"This protein binds beta-galactoside. Its physiological function is not yet known."	""	"TRUE"
"3034-1_2"	"SL004271"	"GFAP"	"Glial fibrillary acidic protein"	"17"	"44905008"	"44916937"	"GFAP"	"2670"	"P14136"	"Neural Crest Differentiation"	""	""	"Nuclear signaling by ERBB4"	"Intermediate Filament Polymerization"	""	"diagnosis"	"GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells."	""	"TRUE"
"3035-80_2"	"SL004354"	"IL-19"	"Interleukin-19"	"1"	"206798870"	"206842981"	"IL19"	"29949"	"Q9UHD0"	""	"IL23-mediated signaling events"	""	""	""	""	""	"May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis (By similarity)."	"93"	"TRUE"
"3037-62_1"	"SL001795"	"IL-1b"	"Interleukin-1 beta"	"2"	"112829751"	"112836903"	"IL1B"	"3553"	"P01584"	"Alzheimers Disease|Cytokines and Inflammatory Response|Folate Metabolism|IL-1 signaling pathway|Leptin signaling pathway|MAPK signaling pathway|Monoamine Transport|Myometrial Relaxation and Contraction Pathways|NOD pathway|Regulation of toll-like receptor signaling pathway|Selenium Pathway|Senescence and Autophagy|Serotonin Transporter Activity|TCR Signaling Pathway|Toll-like receptor signaling pathway|Type II interferon signaling (IFNG)|Vitamin B12 Metabolism"	"Cellular roles of Anthrax toxin|IFN-gamma pathway|IL1-mediated signaling events|IL12-mediated signaling events|IL23-mediated signaling events|IL27-mediated signaling events"	""	"CLEC7A/inflammasome pathway|Interleukin-1 processing|Interleukin-1 signaling"	"CNR1/2 -> IL1B/2/4/6/10 production|Dectin-1 (CLEC7A) Signaling|IL1R -> NF-kB signaling|IL1R -> STAT3 signaling|NOD-like Receptors in Pathogen Recognition|Nociception-related IL1B expression targets|Summarized nociception-related expression targets|TLR4 Signaling in Leukocytes|Th17 Cell Differentiation|Toll-like Receptors Act through MYD88-TIRAP Signaling"	"canakinumab|gevokizumab|canakinumab/INS|gallium nitrate"	"diagnosis|efficacy|prognosis"	"Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells."	"93"	"TRUE"
"3038-9_2"	"SL003326"	"I-TAC"	"C-X-C motif chemokine 11"	"4"	"76033682"	"76041415"	"CXCL11"	"6373"	"O14625"	"Regulation of toll-like receptor signaling pathway|Toll-like receptor signaling pathway"	"CXCR3-mediated signaling events"	""	"Chemokine receptors bind chemokines|G alpha (i) signalling events"	"CCR2/5 -> STAT signaling|CCR5 -> TP53 signaling|Nociception-related CCR1 expression targets|Summarized nociception-related expression targets"	""	""	"Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses."	"311"	"TRUE"
"3040-59_1"	"SL000519"	"MIP-1a"	"C-C motif chemokine 3"	"17"	"36088256"	"36090502"	"CCL3"	"6348"	"P10147"	"Regulation of toll-like receptor signaling pathway|Senescence and Autophagy|Toll-like receptor signaling pathway"	"IL12-mediated signaling events"	""	"Chemokine receptors bind chemokines"	"CCR1 -> STAT signaling|CCR2/5 -> STAT signaling|CCR5 -> TP53 signaling|Nociception-related CCR1 expression targets|Summarized nociception-related expression targets"	""	"diagnosis|efficacy|prognosis"	"Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV)."	"87|88"	"TRUE"
"3041-55_2"	"SL008416"	"MRC2"	"C-type mannose receptor 2"	"17"	"62627401"	"62693597"	"MRC2"	"9902"	"Q9UBG0"	"Epithelium TarBase|Leukocyte TarBase|Lymphocyte TarBase|Muscle cell TarBase|Squamous cell  TarBase"	""	""	"Cross-presentation of soluble exogenous antigens (endosomes)"	""	""	""	"May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs)."	""	"TRUE"
"3042-7_2"	"SL000164"	"Myoglobin"	"Myoglobin"	"22"	"35606764"	"35637951"	"MB"	"4151"	"P02144"	"Effects of nitric oxide"	""	""	""	"Heme biosynthesis"	""	"diagnosis|safety|unspecified application"	"Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles."	""	"TRUE"
"3043-49_2"	"SL000532"	"ON"	"SPARC"	"5"	"151661096"	"151687165"	"SPARC"	"6678"	"P09486"	"Muscle cell TarBase|Senescence and Autophagy"	""	""	"ECM proteoglycans|Platelet degranulation|Scavenging by Class H Receptors"	""	""	"disease progression|efficacy"	"Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity."	""	"TRUE"
"3044-3_2"	"SL003323"	"PARC"	"C-C motif chemokine 18"	"17"	"36064280"	"36072032"	"CCL18"	"6362"	"P55774"	""	""	""	""	""	""	"efficacy|safety"	"Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses."	"87|88|359"	"TRUE"
"3045-72_2"	"SL002704"	"PTN"	"Pleiotrophin"	"7"	"137227341"	"137343865"	"PTN"	"5764"	"P21246"	""	"Syndecan-3-mediated signaling events"	""	""	"ALK -> STAT signaling|MDK/PTN Expression Targets"	""	""	"Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation."	""	"TRUE"
"3046-31_1"	"SL004260"	"resistin"	"Resistin"	"19"	"7669044"	"7670454"	"RETN"	"56729"	"Q9HD89"	"Adipogenesis"	""	""	""	""	""	"diagnosis|efficacy"	"Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes."	""	"TRUE"
"3049-61_2"	"SL000603"	"Trypsin"	"Trypsin-1"	"7"	"142749468"	"142793793"	"PRSS1"	"5644"	"P07477"	""	""	""	"Activation of Matrix Metalloproteinases|Cobalamin (Cbl, vitamin B12) transport and metabolism"	""	""	""	"Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates."	""	"TRUE"
"3050-7_2"	"SL000017"	"vWF"	"von Willebrand factor"	"12"	"5948874"	"6124770"	"VWF"	"7450"	"P04275"	"Blood Clotting Cascade|Complement and Coagulation Cascades|Focal Adhesion"	""	""	"GP1b-IX-V activation signalling|GRB2:SOS provides linkage to MAPK signaling for Integrins|Integrin alphaIIb beta3 signaling|Integrin cell surface interactions|Intrinsic Pathway of Fibrin Clot Formation|Platelet Adhesion to exposed collagen|Platelet degranulation|p130Cas linkage to MAPK signaling for integrins"	""	""	"diagnosis|efficacy|prognosis"	"Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma."	"36"	"TRUE"
"3052-8_2"	"SL000633"	"Fas ligand, soluble"	"Tumor necrosis factor ligand superfamily member 6, soluble form"	"1"	"172659018"	"172666874"	"FASLG"	"356"	"P48023"	"Apoptosis|Apoptosis Modulation and Signaling|DNA damage response (only ATM dependent)|FAS pathway and Stress induction of HSP regulation|MAPK signaling pathway"	"Calcineurin-regulated NFAT-dependent transcription in lymphocytes|Calcium signaling in the CD4+ TCR pathway|Caspase Cascade in Apoptosis|Downstream signaling in naïve CD8+ T cells|FAS (CD95) signaling pathway|FoxO family signaling|HIV-1 Nef: Negative effector of Fas and TNF-alpha|IL12-mediated signaling events|IL2 signaling events mediated by STAT5"	""	"FasL/ CD95L signaling"	"Apoptosis|CD8+ T-cell Activation|Cell Death Mediated by Cytotoxic Cells|Central T-cell Tolerance|Natural Killer Cell Activation|Natural Killer Cell Activation through C-type Lectin-like Receptors|Natural Killer Cell Activation through ITAM-Containing Receptors|Natural Killer Cell Activation through ITSM-Containing Receptors|Peripheral T-cell Tolerance Overview|TNFR -> AP-1/ATF/TP53 signaling|TNFR -> CREB/ELK-SRF signaling|TNFR -> NF-kB signaling|TNFRSF5/6 -> RB1/E2F signaling|TNFRSF6 -> DDIT3 signaling|TNFRSF6 -> FOXO3A signaling|TNFRSF6 -> HSF1 signaling"	""	"diagnosis|efficacy"	"Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects."	""	"TRUE"
"3053-49_2"	"SL004343"	"Flt3 ligand"	"Fms-related tyrosine kinase 3 ligand"	"19"	"49474207"	"49486231"	"FLT3LG"	"2323"	"P49771"	""	""	""	""	"V(D)J Recombination Activation"	""	""	"Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins."	""	"TRUE"
"3054-3_2"	"SL000437"	"Haptoglobin, Mixed Type"	"Haptoglobin"	"16"	"72054592"	"72061055"	"HP"	"3240"	"P00738"	""	""	""	"Scavenging of heme from plasma"	""	""	"diagnosis|efficacy|unspecified application"	"As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway."	"46|67|86|181|267|281|319"	"TRUE"
"3055-54_2"	"SL003308"	"IL-4 sR"	"Interleukin-4 receptor subunit alpha"	"16"	"27313668"	"27364778"	"IL4R"	"3566"	"P24394"	"IL-4 signaling pathway|Inflammatory Response Pathway"	"IL4-mediated signaling events|p73 transcription factor network"	""	""	"Activation of Immunoglobulin Class-Switch Recombination|IL13R -> STAT signaling|IL13R -> STAT6 signaling|IL4R -> ELK-SRF/HMGY signaling|IL4R -> STAT signaling|T-cell-Dependent B-cell Activation|Th2 Cell Differentiation"	""	"response to therapy|unspecified application"	"Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2."	""	"TRUE"
"3056-11_1"	"SL005204"	"NKG2D"	"NKG2-D type II integral membrane protein"	"12"	"10372353"	"10391874"	"KLRK1"	"22914"	"P26718"	""	""	""	"DAP12 interactions|DAP12 signaling|Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"	""	""	""	"Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4."	"332"	"TRUE"
"3057-55_1"	"SL004689"	"WISP-1"	"WNT1-inducible-signaling pathway protein 1"	"8"	"133191039"	"133230344"	"WISP1"	"8840"	"O95388"	""	""	""	""	""	""	""	"Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan."	"82"	"TRUE"
"3059-50_2"	"SL004327"	"BAFF"	"Tumor necrosis factor ligand superfamily member 13B"	"13"	"108251240"	"108308484"	"TNFSF13B"	"10673"	"Q9Y275"	""	""	""	""	"Activation of Immunoglobulin Class-Switch Recombination|T-cell-Independent B-cell Activation|TNFR -> AP-1/ATF/TP53 signaling|TNFR -> CREB/ELK-SRF signaling|TNFR -> NF-kB signaling|TNFRSF5/13B -> NFATC1 signaling"	"belimumab"	"efficacy|response to therapy"	"Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response."	""	"TRUE"
"3060-43_2"	"SL000325"	"C9"	"Complement component C9"	"5"	"39284262"	"39424868"	"C9"	"735"	"P02748"	"Complement Activation, Classical Pathway|Complement and Coagulation Cascades"	""	""	"Regulation of Complement cascade|Terminal pathway of complement"	"Alternative Complement Pathway|Classical Complement Pathway|Lectin-Induced Complement Pathway"	""	""	"Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC."	""	"TRUE"
"3061-61_2"	"SL000343"	"Cathepsin B"	"Cathepsin B"	"8"	"11842524"	"11869448"	"CTSB"	"1508"	"P07858"	""	""	""	"Assembly of collagen fibrils and other multimeric structures|Collagen degradation|MHC class II antigen presentation|Trafficking and processing of endosomal TLR"	""	""	""	"Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis."	"145"	"TRUE"
"3065-65_1"	"SL004339"	"FGF-5"	"Fibroblast growth factor 5"	"4"	"80266599"	"80336680"	"FGF5"	"2250"	"P12034"	"Regulation of Actin Cytoskeleton"	""	""	"Activated point mutants of FGFR2|Constitutive Signaling by Aberrant PI3K in Cancer|FGFR1c ligand binding and activation|FGFR2c ligand binding and activation|FGFR3 mutant receptor activation|FGFR3c ligand binding and activation|FRS-mediated FGFR1 signaling|FRS-mediated FGFR2 signaling|FRS-mediated FGFR3 signaling|Negative regulation of FGFR1 signaling|Negative regulation of FGFR2 signaling|Negative regulation of FGFR3 signaling|PI-3K cascade:FGFR1|PI-3K cascade:FGFR2|PI-3K cascade:FGFR3|PI3K Cascade|PIP3 activates AKT signaling|Phospholipase C-mediated cascade, FGFR2|Phospholipase C-mediated cascade, FGFR3|Phospholipase C-mediated cascade: FGFR1|SHC-mediated cascade:FGFR1|SHC-mediated cascade:FGFR2|SHC-mediated cascade:FGFR3|Signaling by FGFR1 mutants|Signaling by FGFR2 mutants|Signaling by FGFR3 mutants|Signaling by FGFR4 mutants|Signaling by activated point mutants of FGFR1|Signaling by activated point mutants of FGFR3"	"FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling|FGFR -> RUNX2 signaling|FGFR1 -> STAT signaling"	""	""	"Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By similarity)."	""	"TRUE"
"3066-12_1"	"SL003744"	"Galectin-3"	"Galectin-3"	"14"	"55124110"	"55145413"	"LGALS3"	"3958"	"P17931"	""	"Hedgehog signaling events mediated by Gli proteins|Regulation of Ras family activation"	""	"Advanced glycosylation endproduct receptor signaling"	""	""	"diagnosis|unspecified application"	"Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells."	"254"	"TRUE"
"3067-67_1"	"SL005234"	"GDF-9"	"Growth/differentiation factor 9"	"5"	"132861181"	"132866884"	"GDF9"	"2661"	"O60383"	"Ovarian Infertility Genes"	""	""	""	"TGFBR/BMPR -> SMAD2/3 signaling"	""	""	"Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells."	""	"TRUE"
"3069-52_3"	"SL000468"	"IgM"	"Immunoglobulin M"	"14"	"106318037"	"106322323"	"IGHM|IGJ|IGK@|IGL@"	"3507|3512|50802|3535"	"P01871"	""	""	""	"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"	""	""	""	"IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts."	""	"TRUE"
"3070-1_2"	"SL000478"	"IL-2"	"Interleukin-2"	"4"	"122451470"	"122456725"	"IL2"	"3558"	"P60568"	"Cytokines and Inflammatory Response|Folate Metabolism|IL-2 Signaling pathway|IL-5 signaling pathway|Inflammatory Response Pathway"	"AP-1 transcription factor network|Calcineurin-regulated NFAT-dependent transcription in lymphocytes|Calcium signaling in the CD4+ TCR pathway|Downstream signaling in naïve CD8+ T cells|Glucocorticoid receptor regulatory network|IL12 signaling mediated by STAT4|IL12-mediated signaling events|IL2 signaling events mediated by PI3K|IL2 signaling events mediated by STAT5|IL2-mediated signaling events|IL23-mediated signaling events|IL27-mediated signaling events|Regulation of Telomerase|SHP2 signaling"	""	"G beta:gamma signalling through PI3Kgamma|GPVI-mediated activation cascade|Interleukin receptor SHC signaling|Interleukin-2 signaling"	"CD8+ T-cell Activation|CHRM1 -> IL2 production|CNR1/2 -> IL1B/2/4/6/10 production|Dectin-1 (CLEC7A) Signaling|IL2R -> ELK-SRF/MYC signaling|IL2R -> STAT signaling|Model of T-cell Maturation|Natural Killer Cell Activation|Natural Killer Cell Activation through C-type Lectin-like Receptors|Natural Killer Cell Activation through ITAM-Containing Receptors|Natural Killer Cell Activation through ITSM-Containing Receptors|Nociception-related IL1B expression targets|OPRK -> pain perception|PTGER2/3 -> inflammation-related expression targets|Regulatory T-cell Differentiation|Summarized nociception-related expression targets|T-cell Positive Selection and Neglect-Induced Death|T-cell Receptor Signaling|T-cell-Dependent B-cell Activation|Th2 Cell Differentiation"	""	"diagnosis|disease progression|efficacy|response to therapy"	"Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells."	""	"TRUE"
"3072-4_2"	"SL001718"	"IL-13"	"Interleukin-13"	"5"	"132656263"	"132661110"	"IL13"	"3596"	"P35225"	"Cytokines and Inflammatory Response"	"Glucocorticoid receptor regulatory network|IL12 signaling mediated by STAT4"	""	""	"Activation of Immunoglobulin Class-Switch Recombination|IL13R -> STAT signaling|IL13R -> STAT6 signaling|Model of T-cell Maturation|Th2 Cell Differentiation|Transcriptional Activation of Immunoglobulin Genes"	"CAT-354"	"diagnosis|efficacy|response to therapy|unspecified application"	"Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses."	""	"TRUE"
"3073-51_2"	"SL002508"	"IL-18 BPa"	"Interleukin-18-binding protein"	"11"	"71998541"	"72005715"	"IL18BP"	"10068"	"O95998"	""	""	""	""	""	""	""	"Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response."	""	"TRUE"
"3077-66_2"	"SL003324"	"Coagulation Factor Xa"	"Coagulation factor Xa"	"13"	"113122814"	"113149529"	"F10"	"2159"	"P00742"	"Blood Clotting Cascade|Complement and Coagulation Cascades"	"Beta2 integrin cell surface interactions"	""	"Common Pathway of Fibrin Clot Formation|Extrinsic Pathway of Fibrin Clot Formation|Gamma-carboxylation of protein precursors|Intrinsic Pathway of Fibrin Clot Formation|Removal of aminoterminal propeptides from gamma-carboxylated proteins|Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus"	"Coagulation Cascade|Vitamin K metabolism"	"dalteparin|heparin|enoxaparin|rivaroxaban|deligoparin|idraparinux|tifacogin|RPR 120844|RPR 208566|DPC 423|nematode anticoagulant protein c2|apixaban|activated recombinant human factor VII|F8|edoxaban|F9|fondaparinux"	"efficacy"	"Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting."	""	"TRUE"
"3078-1_2"	"SL002640"	"PlGF"	"Placenta growth factor"	"14"	"74941834"	"74955784"	"PGF"	"5228"	"P49763"	"Focal Adhesion"	"VEGF and VEGFR signaling network|VEGFR1 specific signals"	""	"VEGF binds to VEGFR leading to receptor dimerization|VEGF ligand-receptor interactions"	""	"aflibercept|aflibercept/irinotecan"	"diagnosis|disease progression|efficacy|prognosis"	"Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth."	""	"TRUE"
"3079-62_2"	"SL005152"	"TIG2"	"Retinoic acid receptor responder protein 2"	"7"	"150338317"	"150341674"	"RARRES2"	"5919"	"Q99969"	""	""	""	""	""	""	""	"Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Its other ligands include G protein-coupled receptor 1 (GPR1) and chemokine receptor-like 2 (CCRL2). Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a proinflammatory adipokine, causing an increase in secretion of proinflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chemotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells. Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells. The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production. Its dual role in inflammation and metabolism might provide a link between chronic inflammation and obesity, as well as obesity-related disorders such as type 2 diabetes and cardiovascular disease. Exhibits an antimicrobial function in the skin."	"249"	"TRUE"
"3081-70_2"	"SL005227"	"ULBP-1"	"NKG2D ligand 1"	"6"	"149964007"	"149973710"	"ULBP1"	"80329"	"Q9BZM6"	""	""	""	"Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"	"Natural Killer Cell Activation|Natural Killer Cell Activation through C-type Lectin-like Receptors"	""	""	"Ligand for the KLRK1/NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface."	""	"TRUE"
"3082-9_2"	"SL005228"	"ULBP-2"	"NKG2D ligand 2"	"6"	"149942000"	"149949235"	"ULBP2"	"80328"	"Q9BZM5"	""	""	""	""	"Natural Killer Cell Activation"	""	""	"Ligand for the KLRK1/NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface."	""	"TRUE"
"3083-71_1"	"SL005233"	"XEDAR"	"Tumor necrosis factor receptor superfamily member 27"	"X"	"66595637"	"66639298"	"EDA2R"	"60401"	"Q9HAV5"	""	""	""	""	"EctodysplasinR -> AP-1 signaling|EctodysplasinR -> LEF1 signaling|EctodysplasinR -> NF-kB signaling"	""	""	"Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6."	""	"TRUE"
"3091-70_2"	"SL004771"	"Aurora kinase A"	"Aurora kinase A"	"20"	"56369389"	"56392337"	"AURKA"	"6790"	"O14965"	"EGF/EGFR Signaling Pathway|Integrated Breast Cancer Pathway"	"Aurora A signaling|Aurora B signaling|Integrin-linked kinase signaling|PLK1 signaling events|Signaling by Aurora kinases"	""	"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1|Regulation of PLK1 Activity at G2/M Transition"	"Cell Cycle|Chromosome Condensation|Histone Phosphorylation|Sister Chromatid Cohesion"	"tozasertib|MLN8054|danusertib"	"efficacy"	"Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis."	""	"TRUE"
"3104-8_2"	"SL004750"	"DEAD-box protein 19B"	"ATP-dependent RNA helicase DDX19B"	"16"	"70289663"	"70335283"	"DDX19B"	"11269"	"Q9UMR2"	"NA"	"NA"	"NA"	"NA"	"NA"	""	""	"ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins."	""	"TRUE"
"3115-64_2"	"SL006918"	"MK01"	"Mitogen-activated protein kinase 1"	"22"	"21754500"	"21867680"	"MAPK1"	"5594"	"P28482"	"Alpha 6 Beta 4 signaling pathway|Alzheimers Disease|Angiogenesis|B Cell Receptor Signaling Pathway|DNA damage response (only ATM dependent)|EBV LMP1 signaling|EGF/EGFR Signaling Pathway|EPO Receptor Signaling|ErbB signaling pathway|Estrogen signaling pathway|FSH signaling pathway|Focal Adhesion|Heart Development|Hypothetical Network for Drug Addiction|IL-1 signaling pathway|IL-2 Signaling pathway|IL-3 Signaling Pathway|IL-4 signaling pathway|IL-5 signaling pathway|IL-6 signaling pathway|IL-7 signaling pathway|IL-9 signaling pathway|Insulin Signaling|Integrated Breast Cancer Pathway|Integrin-mediated cell adhesion|Kit receptor signaling pathway|Leptin signaling pathway|MAPK Cascade|MAPK signaling pathway|MicroRNAs in cardiomyocyte hypertrophy|Nifedipine Activity|Osteopontin Signaling|Physiological and Pathological Hypertrophy  of the Heart|Prolactin Signaling Pathway|RANKL/RANK Signaling Pathway|Regulation of Actin Cytoskeleton|Regulation of toll-like receptor signaling pathway|Senescence and Autophagy|Signal Transduction of S1P Receptor|Signaling of Hepatocyte Growth Factor Receptor|TCR Signaling Pathway|TGF beta Signaling Pathway|TNF alpha Signaling Pathway|TSH signaling pathway|TWEAK Signaling Pathway|Toll-like receptor signaling pathway|Type II diabetes mellitus|angiogenesis overview"	"ALK1 signaling events|ATF-2 transcription factor network|Alpha-synuclein signaling|Angiopoietin receptor Tie2-mediated signaling|Arf6 downstream pathway|BCR signaling pathway|BMP receptor signaling|CDC42 signaling events|CXCR3-mediated signaling events|Cellular roles of Anthrax toxin|Ceramide signaling pathway|Class IB PI3K non-lipid kinase events|Downstream signaling in naïve CD8+ T cells|EGF receptor (ErbB1) signaling pathway|EPHB forward signaling|Endothelins|ErbB1 downstream signaling|ErbB2/ErbB3 signaling events|ErbB4 signaling events|FGF signaling pathway|Fc-epsilon receptor I signaling in mast cells|GMCSF-mediated signaling events|Glucocorticoid receptor regulatory network|IFN-gamma pathway|IL2-mediated signaling events|Integrins in angiogenesis|Netrin-mediated signaling events|Neurotrophic factor-mediated Trk receptor signaling|Nongenotropic Androgen signaling|Osteopontin-mediated events|PDGFR-beta signaling pathway|Presenilin action in Notch and Wnt signaling|Ras signaling in the CD4+ TCR pathway|Regulation of Telomerase|Regulation of cytoplasmic and nuclear SMAD2/3 signaling|Retinoic acid receptors-mediated signaling|S1P1 pathway|S1P2 pathway|S1P3 pathway|S1P4 pathway|Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)|Signaling events mediated by PRL|Signaling events mediated by VEGFR1 and VEGFR2|Signaling events mediated by focal adhesion kinase|Signaling events regulated by Ret tyrosine kinase|Syndecan-1-mediated signaling events|Syndecan-2-mediated signaling events|TRAIL signaling pathway|Trk receptor signaling mediated by the MAPK pathway|VEGFR1 specific signals|VEGFR3 signaling in lymphatic endothelium|mTOR signaling pathway"	""	"Activation of the AP-1 family of transcription factors|Advanced glycosylation endproduct receptor signaling|CREB phosphorylation through the activation of Ras|ERK/MAPK targets|ERK2 activation|ERKs are inactivated|FCERI mediated MAPK activation|Gastrin-CREB signalling pathway via PKC and MAPK|Golgi Cisternae Pericentriolar Stack Reorganization|Growth hormone receptor signaling|NCAM signaling for neurite out-growth|Negative regulation of FGFR1 signaling|Negative regulation of FGFR2 signaling|Negative regulation of FGFR3 signaling|Negative regulation of FGFR4 signaling|Oncogene Induced Senescence|Oxidative Stress Induced Senescence|RHO GTPases Activate WASPs and WAVEs|RSK activation|Recycling pathway of L1|Regulation of HSF1-mediated heat shock response|Regulation of actin dynamics for phagocytic cup formation|Senescence-Associated Secretory Phenotype (SASP)|Signal attenuation|Signal transduction by L1|Signaling by FGFR1|Signaling by FGFR2|Signaling by FGFR3|Signaling by FGFR4|Thrombin signalling through proteinase activated receptors (PARs)|phospho-PLA2 pathway"	"ADRA1 -> prostaglandin generation|ADRA1 -> vasoconstriction|ADRA1A -> IL6 production|ADRA2C/ADRB2 -> synaptic endocytosis|ADRA2C/ADRB2 -> vasoconstriction|ADRB1 -> prostaglandin generation|AGER ->  CREB/SP1 signaling|AdenosineR -> AP-1 signaling|AdrenergicRa -> ELK-SRF signaling|AdrenergicRa -> STAT3 signaling|AdrenergicRb -> CREB signaling|AngiopoietinR -> AP-1 signaling|AngiotensinR -> CREB/ELK-SRF/TP53 signaling|B-cell receptor -> AP-1 signaling|BDKRB1/2 -> prostaglandin generation|CD19 ->  AP-1/ELK-SRF signaling|CD38 ->  NF-kB signaling|CD8+ T-cell Activation|CHRM1 -> IL2 production|CHRM1/2/3 -> vascular motility|CHRNA7 -> NOS1 production|CNR1/2 -> IL1B/2/4/6/10 production|CannabinoidR -> AP-1/EGR signaling|Cell Cycle|CholecystokininR -> ELK-SRF signaling|CholinergicRm -> CREB/ELK-SRF signaling|CholinergicRn ->  CREB signaling|DopamineR1 -> CREB/ELK-SRF signaling|DopamineR2 -> AP-1/CREB/ELK-SRF signaling|EDG2 -> ELK-SRF signaling|EDG3/5 -> AP-1/ELK-SRF signaling|EDNRA/B -> vascular motility|EGFR -> AP-1/ATF2 signaling|EGFR -> AP-1/CREB/ELK-SRF/MYC signaling|EGFR -> SMAD1 signaling|EGFR/ERBB2 -> HIF1A signaling|EGFR/ERBB2 -> TP53 signaling|ERBB2/3 -> EP300/ETS/ETV/SP1 signaling|EctodysplasinR -> AP-1 signaling|EndothelinRa -> AP-1/CREB signaling|EndothelinRb -> AP-1/CREB/ELK-SRF signaling|ErythropoietinR -> AP-1/CREB/MYC signaling|ErythropoietinR -> ELK-SRF/FOS signaling|FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling|FGFR -> RUNX2 signaling|FSHR -> CREB/ELK-SRF/GATA4 signaling|FcIgER -> ELK-SRF signaling|FibronectinR -> AP-1/ELK-SRF/SREBF signaling|GALR1/2/3 -> POMC/NPY production|GDNF -> HSF1 signaling|GHR -> ELK-SRF/MYC signaling|GNRHR -> ELK-SRF signaling|GRM1/5 -> CREB signaling|Gap Junction Assembly|GlucagonR -> CREB/ELK-SRF/SP1 signaling|HGFR -> AP-1/CREB/MYC signaling|HRH2/4 -> IL6/10 production|HTR1 -> IL6 production|HTR4/6/7 -> cation channels|HTR5 -> TNF production|HTR7 -> IL6 production|ICAM1 -> AP-1/CREB/ELK-SRF signaling|IGF1R -> ELK-SRF/HIF1A/MYC/SREBF signaling|IL1R -> NF-kB signaling|IL2R -> ELK-SRF/MYC signaling|IL4R -> ELK-SRF/HMGY signaling|IL6R -> CEBP/ELK-SRF signaling|IL8R -> CREB/EGR signaling|InsulinR -> ELK-SRF/SREBF signaling|KIT -> MITF signaling|LeptinR -> ELK-SRF signaling|Model of T-cell Maturation|NCAM1 -> CREB/ELK-SRF/MYC signaling|NGFR -> AP-1/CEBPB/CREB/ELK-SRF/TP53 signaling|NMDA receptors -> Ca2+/CREB activation/PGE2 synthesis|NPY1R -> CRH/POMC production|NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling|Natural Killer Cell Activation|Natural Killer Cell Activation through C-type Lectin-like Receptors|Natural Killer Cell Activation through ITAM-Containing Receptors|Natural Killer Cell Activation through ITSM-Containing Receptors|NeuropeptideYR -> ATF/CREB signaling|NeurotensinR -> ELK-SRF/AP-1/EGR signaling|Nociception-related DRD1/5 expression targets|Nociception-related DRD2 expression targets|Nociception-related IL1B expression targets|Nociception-related IL6 expression targets|Nociception-related NTSR1 expression targets|Notch -> TCF3 signaling|OPRK -> pain perception|OpioidR -> CREB/ELK-SRF/STAT3 signaling|OxytocinR -> ELK-SRF/GATA/AP-1 signaling|P2RY11/13/14 -> IL8/10 production|PDGFR -> AP-1/MYC signaling|PECAM -> SP1 signaling|PTAFR -> AP-1/ATF1/CREB/ERK-SRF signaling|PTGER1/4 -> vascular motility|PTGER2/3 -> inflammation-related expression targets|PTGIR -> IL6 production|PTPRC -> BCL6 signaling|ProstaglandinFR -> ATF1/ELK-SRF/CREB signaling|ProstaglandinIR -> ATF1/ELK-SRF/CREB signaling|Regulation of potassium flux|Regulatory T-cell Differentiation|SELE -> ELK-SRF signaling|SerotoninR1 -> FOS signaling|SerotoninR2 -> ELK-SRF/GATA4 signaling|SerotoninR4/6/7 -> NR3C signaling|Summarized nociception-related expression targets|Summarized vascular motility pathway|T-cell Receptor Signaling|T-cell receptor -> AP-1 signaling|T-cell-Dependent B-cell Activation|T-cell-Independent B-cell Activation|TLR4 Signaling in Leukocytes|TNFR -> AP-1/ATF/TP53 signaling|TNFR -> CREB/ELK-SRF signaling|TNFRSF1A -> AP-1/ATF/TP53 signaling|TNFRSF1A -> CREB/ELK-SRF signaling|TNFRSF6 -> HSF1 signaling|TachykininR -> ELK-SRF signaling|Th1 Cell Differentiation|Th2 Cell Differentiation|ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling|ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling|ThrombopoietinR -> SP1 signaling|ThromboxaneR -> CREB signaling|Toll-like Receptors Act through MYD88-TIRAP Signaling|UrokinaseR -> ELK-SRF signaling|V(D)J Recombination Activation|VEGFR -> AP-1/CREB/MYC signaling|VEGFR -> ATF/CREB/ELK-SRF signaling|VIPR -> CREB/CEBP signaling|VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling|VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling"	"ARRY-438162"	"efficacy"	"Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in respons to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation."	""	"TRUE"
"3122-6_2"	"SL003733"	"SMAC"	"Diablo homolog, mitochondrial"	"12"	"122207662"	"122227534"	"DIABLO"	"56616"	"Q9NR28"	"Apoptosis|Apoptosis Modulation and Signaling|TNF alpha Signaling Pathway"	"Caspase Cascade in Apoptosis|p75(NTR)-mediated signaling"	""	"Release of apoptotic factors from the mitochondria|SMAC binds to IAPs|SMAC-mediated dissociation of IAP:caspase complexes"	"Apoptosis"	""	""	"Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance."	""	"TRUE"
"3132-1_1"	"SL004486"	"VEGF-C"	"Vascular endothelial growth factor C"	"4"	"176683538"	"176792727"	"VEGFC"	"7424"	"P49767"	"Focal Adhesion|Heart Development"	"Alpha9 beta1 integrin signaling events|VEGF and VEGFR signaling network|VEGFR3 signaling in lymphatic endothelium"	""	"Platelet degranulation|VEGF binds to VEGFR leading to receptor dimerization|VEGF ligand-receptor interactions"	"VEGFR -> AP-1/CREB/MYC signaling|VEGFR -> ATF/CREB/ELK-SRF signaling|VEGFR -> CTNNB signaling|VEGFR -> CTNND signaling|VEGFR -> FOXO3A signaling|VEGFR -> NFATC signaling|VEGFR -> STAT signaling"	""	"diagnosis|disease progression|efficacy|prognosis"	"Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors."	""	"TRUE"
"3143-3_1"	"SL002524"	"sCD4"	"T-cell surface glycoprotein CD4"	"12"	"6786858"	"6820808"	"CD4"	"920"	"P01730"	"Cytokines and Inflammatory Response|TCR Signaling Pathway"	"Arf1 pathway|C-MYB transcription factor network|CXCR4-mediated signaling events|IL12 signaling mediated by STAT4|IL12-mediated signaling events|IL23-mediated signaling events|Notch-mediated HES/HEY network|TCR signaling in naïve CD4+ T cells"	""	"Alpha-defensins|Binding and entry of HIV virion|Downstream TCR signaling|Generation of second messenger molecules|Nef Mediated CD4 Down-regulation|PD-1 signaling|Phosphorylation of CD3 and TCR zeta chains|Translocation of ZAP-70 to Immunological synapse|Vpu mediated degradation of CD4"	"HRH2/4 -> IL6/10 production|MHC2-Mediated Antigen Presentation|Model of T-cell Maturation|Regulatory T-cell Differentiation|T-cell Receptor Signaling|T-cell receptor -> AP-1 signaling|T-cell receptor -> ATF/CREB signaling|T-cell receptor -> CREBBP signaling|T-cell receptor -> NF-kB signaling|T-cell receptor -> NFATC signaling|T-cell receptor -> STAT signaling|Th1 Cell Differentiation|Th17 Cell Differentiation|Th2 Cell Differentiation"	""	"diagnosis|efficacy"	"Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts."	""	"TRUE"
"3151-6_1"	"SL003305"	"IL-2 sRa"	"Interleukin-2 receptor subunit alpha"	"10"	"6010689"	"6062325"	"IL2RA"	"3559"	"P01589"	"IL-2 Signaling pathway|IL-7 signaling pathway|Inflammatory Response Pathway"	"Arf6 trafficking events|Calcineurin-regulated NFAT-dependent transcription in lymphocytes|Calcium signaling in the CD4+ TCR pathway|Downstream signaling in naïve CD8+ T cells|IL12 signaling mediated by STAT4|IL12-mediated signaling events|IL2 signaling events mediated by PI3K|IL2 signaling events mediated by STAT5|IL2-mediated signaling events|SHP2 signaling"	""	"G beta:gamma signalling through PI3Kgamma|GPVI-mediated activation cascade|Interleukin receptor SHC signaling|Interleukin-2 signaling"	"CD8+ T-cell Activation|IL2R -> ELK-SRF/MYC signaling|IL2R -> STAT signaling|Leptin -> CD25/IL6/IL10 production|Model of T-cell Maturation|Natural Killer Cell Activation|Nociception-related IL6 expression targets|Regulatory T-cell Differentiation|T-cell-Dependent B-cell Activation|Th2 Cell Differentiation"	"LMB-2|daclizumab|basiliximab|aldesleukin|denileukin diftitox"	"efficacy"	"Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T cells."	""	"TRUE"
"3152-57_1"	"SL001800"	"TNF sR-II"	"Tumor necrosis factor receptor superfamily member 1B"	"1"	"12167003"	"12209228"	"TNFRSF1B"	"7133"	"P20333"	"Apoptosis|Apoptosis Modulation and Signaling|Inflammatory Response Pathway|TNF alpha Signaling Pathway"	"TNF receptor signaling pathway"	""	""	"GFs/TNF -> ion channels|TNFR -> AP-1/ATF/TP53 signaling|TNFR -> CREB/ELK-SRF signaling|TNFR -> NF-kB signaling"	""	"efficacy|safety"	"Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity."	""	"TRUE"
"3166-92_1"	"SL005215"	"Siglec-3"	"Myeloid cell surface antigen CD33"	"19"	"51225064"	"51243860"	"CD33"	"945"	"P20138"	""	""	""	""	""	"arsenic trioxide/gemtuzumab ozogamicin/tretinoin|gemtuzumab ozogamicin"	"efficacy"	"Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro)."	"7|221|223"	"TRUE"
"3168-8_2"	"SL004626"	"ADAMTS-5"	"A disintegrin and metalloproteinase with thrombospondin motifs 5"	"21"	"26917912"	"26966513"	"ADAMTS5"	"11096"	"Q9UNA0"	"Endochondral Ossification"	""	""	"Degradation of the extracellular matrix|O-glycosylation of TSR domain-containing proteins"	""	""	""	"Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period."	"23|268|383"	"TRUE"
"3169-70_2"	"SL010368"	"IDUA"	"alpha-L-iduronidase"	"4"	"986997"	"1004506"	"IDUA"	"3425"	"P35475"	""	""	""	"CS/DS degradation|HS-GAG degradation|MPS I - Hurler syndrome"	""	""	""	"Hydrolysis of unsulfated alpha-L-iduronosidic linkages in dermatan sulfate."	""	"TRUE"
"3170-6_1"	"SL007261"	"AMPM2"	"Methionine aminopeptidase 2"	"12"	"95473520"	"95515839"	"METAP2"	"10988"	"P50579"	""	""	""	""	""	"nitroxoline|beloranib|PPI-2458"	"unspecified application"	"Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo."	"353"	"TRUE"
"3171-57_2"	"SL004469"	"amyloid precursor protein"	"Amyloid beta A4 protein"	"21"	"25880550"	"26171128"	"APP"	"351"	"P05067"	"Alzheimers Disease"	"Caspase Cascade in Apoptosis|Glypican 1 network|p75(NTR)-mediated signaling"	""	"Advanced glycosylation endproduct receptor signaling|Amyloids|DEx/H-box helicases activate type I IFN and inflammatory cytokines production|ECM proteoglycans|Formyl peptide receptors bind formyl peptides and many other ligands|G alpha (i) signalling events|G alpha (q) signalling events|Lysosome Vesicle Biogenesis|Platelet degranulation|RIP-mediated NFkB activation via ZBP1|TAK1 activates NFkB by phosphorylation and activation of IKKs complex|TRAF6 mediated NF-kB activation|The NLRP3 inflammasome"	"Apoptosis|CHRNA3-B4/A4-B2/A7 -> ion transport|CHRNA7 -> IL8 production|CHRNA7 -> NOS1 production|GFs/TNF -> ion channels"	"bapineuzumab|florbetapir F18|florbetaben F"	"diagnosis|efficacy|unspecified application"	"Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1."	""	"TRUE"
"3172-28_2"	"SL008956"	"ARSB"	"Arylsulfatase B"	"5"	"78777209"	"78986087"	"ARSB"	"411"	"P15848"	""	""	""	"CS/DS degradation|Glycosphingolipid metabolism|MPS VI - Maroteaux-Lamy syndrome|The activation of arylsulfatases"	""	""	""	"Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed:19306108). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (PubMed:19306108). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity)."	"252|318"	"TRUE"
"3173-49_2"	"SL008611"	"ASAHL"	"N-acylethanolamine-hydrolyzing acid amidase"	"4"	"75913657"	"75941051"	"NAAA"	"27163"	"Q02083"	""	""	""	""	""	""	""	"Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine > N-arachidonoylethanolamine > N-oleoylethanolamine. Also exhibits weak hydrolytic activity against the ceramides N-lauroylsphingosine and N-palmitoylsphingosine."	"83|337|389"	"TRUE"
"3174-2_1"	"SL008421"	"ATS1"	"A disintegrin and metalloproteinase with thrombospondin motifs 1"	"21"	"26835747"	"26845409"	"ADAMTS1"	"9510"	"Q9UHI8"	"Endochondral Ossification"	""	""	"Degradation of the extracellular matrix|O-glycosylation of TSR domain-containing proteins"	"Extracellular Matrix Turnover"	""	""	"Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture."	""	"TRUE"
"3175-51_5"	"SL006610"	"ATS13"	"A disintegrin and metalloproteinase with thrombospondin motifs 13"	"9"	"133414358"	"133459402"	"ADAMTS13"	"11093"	"Q76LX8"	""	""	""	"O-glycosylation of TSR domain-containing proteins"	""	""	""	"Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation."	"191|354|371"	"TRUE"
"3177-49_2"	"SL010369"	"Carbonic Anhydrase IV"	"Carbonic anhydrase 4"	"17"	"60149936"	"60170899"	"CA4"	"762"	"P22748"	""	""	""	"Erythrocytes take up carbon dioxide and release oxygen|Erythrocytes take up oxygen and release carbon dioxide|Reversible hydration of carbon dioxide"	""	"ethoxyzolamide|dichlorphenamide|phentermine/topiramate|methazolamide|hydrochlorothiazide|acetazolamide|trichloromethiazide|chlorothiazide|chlorothiazide/reserpine|chlorthalidone|benzthiazide|sulfacetamide|topiramate"	""	"Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid."	""	"TRUE"
"3178-5_2"	"SL007280"	"CATC"	"Dipeptidyl peptidase 1"	"11"	"88293592"	"88337787"	"CTSC"	"1075"	"P53634"	"Epithelium TarBase|Leukocyte TarBase|Lymphocyte TarBase|Muscle cell TarBase"	""	""	"MHC class II antigen presentation"	""	""	"unspecified application"	"Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII."	""	"TRUE"
"3179-51_2"	"SL009213"	"Cathepsin A"	"Lysosomal protective protein"	"20"	"45890144"	"45898820"	"CTSA"	"5476"	"P10619"	""	""	""	"Glycosphingolipid metabolism|MHC class II antigen presentation|Sialic acid metabolism"	""	""	""	"Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins."	"335"	"TRUE"
"3180-46_2"	"SL000344"	"Cathepsin D"	"Cathepsin D"	"11"	"1752752"	"1763992"	"CTSD"	"1509"	"P07339"	"NA"	"NA"	"NA"	"NA"	"NA"	""	"diagnosis|unspecified application"	"Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease."	""	"TRUE"
"3181-50_2"	"SL004673"	"Cathepsin S"	"Cathepsin S"	"1"	"150730196"	"150765957"	"CTSS"	"1520"	"P25774"	""	""	""	"Assembly of collagen fibrils and other multimeric structures|Degradation of the extracellular matrix|Endosomal/Vacuolar pathway|MHC class II antigen presentation|Trafficking and processing of endosomal TLR"	"MHC2-Mediated Antigen Presentation"	""	""	"Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N."	"97|201"	"TRUE"
"3182-38_2"	"SL010371"	"CD39"	"Ectonucleoside triphosphate diphosphohydrolase 1"	"10"	"95711779"	"95877266"	"ENTPD1"	"953"	"P49961"	""	""	""	""	""	""	""	"In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well."	""	"TRUE"
"3184-25_2"	"SL000358"	"Coagulation Factor VII"	"Coagulation Factor VII"	"13"	"113105788"	"113120681"	"F7"	"2155"	"P08709"	"Blood Clotting Cascade|Complement and Coagulation Cascades|Folate Metabolism|Selenium Pathway|Vitamin B12 Metabolism"	""	""	"BMAL1:CLOCK,NPAS2 activates circadian gene expression|Extrinsic Pathway of Fibrin Clot Formation|Gamma-carboxylation of protein precursors|Removal of aminoterminal propeptides from gamma-carboxylated proteins|Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus"	"Coagulation Cascade|Vitamin K metabolism"	"nematode anticoagulant protein c2"	"unspecified application"	"Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium."	"58"	"TRUE"
"3186-2_2"	"SL002525"	"C2"	"Complement C2"	"6"	"31879966"	"32022117"	"C2"	"717"	"P06681"	"Complement Activation, Classical Pathway|Complement and Coagulation Cascades"	""	""	"Activation of C3 and C5|Initial triggering of complement|Regulation of Complement cascade"	"Classical Complement Pathway|Lectin-Induced Complement Pathway"	""	""	"Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase."	""	"TRUE"
"3187-52_2"	"SL007284"	"CRIS3"	"Cysteine-rich secretory protein 3"	"6"	"49727384"	"49744437"	"CRISP3"	"10321"	"P54108"	""	""	""	""	""	""	""	"Interacts with A1BG."	""	"TRUE"
"3189-61_2"	"SL010372"	"Enterokinase"	"Enteropeptidase"	"21"	"18269116"	"18485879"	"TMPRSS15"	"5651"	"P98073"	""	""	""	""	""	""	""	"Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases."	""	"TRUE"
"3190-43_1"	"SL000658"	"GAS1"	"Growth arrest-specific protein 1"	"9"	"86944363"	"86947189"	"GAS1"	"2619"	"P54826"	"NA"	"NA"	"NA"	"NA"	"NA"	""	""	"Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells."	""	"TRUE"
"3191-50_2"	"SL012783"	"WFKN1"	"WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 1"	"16"	"629239"	"634116"	"WFIKKN1"	"117166"	"Q96NZ8"	""	""	""	""	""	""	""	"Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity (By similarity)."	""	"TRUE"
"3192-3_2"	"SL002695"	"Glutamate carboxypeptidase"	"Cytosolic non-specific dipeptidase"	"18"	"74495816"	"74523454"	"CNDP2"	"55748"	"Q96KP4"	""	""	""	"Glutathione synthesis and recycling|Sulfur amino acid metabolism"	""	""	""	"Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly (PubMed:19346245). Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation (PubMed:24395568). Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells (PubMed:17121880). Catalyzes the production of N-lactoyl-amino acids from lactate and amino acids by reverse proteolysis (PubMed:25964343)."	""	"TRUE"
"3194-36_2"	"SL008759"	"GPVI"	"Platelet glycoprotein VI"	"19"	"54684540"	"55071420"	"GP6"	"51206"	"Q9HCN6"	""	""	""	"Cell surface interactions at the vascular wall|GPVI-mediated activation cascade|Platelet Adhesion to exposed collagen"	""	""	""	"Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2."	"126|355"	"TRUE"
"3195-50_2"	"SL000678"	"Granulysin"	"Granulysin"	"2"	"85685175"	"85698854"	"GNLY"	"10578"	"P22749"	""	""	""	""	""	""	""	"Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis."	"45|299"	"TRUE"
"3196-6_2"	"SL008023"	"HPLN1"	"Hyaluronan and proteoglycan link protein 1"	"5"	"83637805"	"83721613"	"HAPLN1"	"1404"	"P10915"	""	""	""	"ECM proteoglycans"	""	""	""	"Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix."	""	"TRUE"
"3197-70_2"	"SL007122"	"IDE"	"Insulin-degrading enzyme"	"10"	"92451684"	"92574076"	"IDE"	"3416"	"P14735"	"Alzheimers Disease"	""	""	""	""	"bacitracin"	""	"Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia."	""	"TRUE"
"3198-4_1"	"SL008639"	"IDS"	"Iduronate 2-sulfatase"	"X"	"149476990"	"149521096"	"IDS"	"3423"	"P22304"	""	""	""	"CS/DS degradation|HS-GAG degradation|MPS II - Hunter syndrome"	""	""	""	"Required for the lysosomal degradation of heparan sulfate and dermatan sulfate."	""	"TRUE"
"3199-54_2"	"SL003916"	"kallikrein 12"	"Kallikrein-12"	"19"	"51029092"	"51035230"	"KLK12"	"43849"	"Q9UKR0"	""	""	""	""	""	""	""	"Secreted"	"75"	"TRUE"
"3200-49_2"	"SL003918"	"kallikrein 13"	"Kallikrein-13"	"19"	"51056206"	"51065114"	"KLK13"	"26085"	"Q9UKR3"	""	""	""	"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"	""	""	"prognosis"	"Secreted"	""	"TRUE"
"3201-49_2"	"SL003863"	"kallikrein 5"	"Kallikrein-5"	"19"	"50943303"	"50953093"	"KLK5"	"25818"	"Q9Y337"	""	""	""	""	""	""	"diagnosis|prognosis"	"May be involved in desquamation."	""	"TRUE"
"3202-28_2"	"SL010393"	"KREM2"	"Kremen protein 2"	"16"	"2963944"	"2968383"	"KREMEN2"	"79412"	"Q8NCW0"	""	"Presenilin action in Notch and Wnt signaling|Wnt signaling network"	""	"TCF dependent signaling in response to WNT|misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling|negative regulation of TCF-dependent signaling by WNT ligand antagonists"	""	""	""	"Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. Forms a ternary complex with Dkk1 and LRP6 and induces rapid endocytosis and removal of the Wnt receptor LRP6 from the plasma membrane (By similarity)."	""	"TRUE"
"3204-2_2"	"SL007100"	"LKHA4"	"Leukotriene A-4 hydrolase"	"12"	"96000828"	"96043520"	"LTA4H"	"4048"	"P09960"	"Eicosanoid Synthesis"	""	"leukotriene B4 biosynthesis"	"Synthesis of Leukotrienes (LT) and Eoxins (EX)"	""	""	""	"Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity."	""	"TRUE"
"3206-4_2"	"SL008904"	"LYVE1"	"Lymphatic vessel endothelial hyaluronic acid receptor 1"	"11"	"10556966"	"10611689"	"LYVE1"	"10894"	"Q9Y5Y7"	""	""	""	"Hyaluronan uptake and degradation"	""	""	"disease progression"	"Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes."	""	"TRUE"
"3208-2_4"	"SL006992"	"MATN3"	"Matrilin-3"	"2"	"19992111"	"20012694"	"MATN3"	"4148"	"O15232"	""	""	""	"ECM proteoglycans"	""	""	""	"Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks."	""	"TRUE"
"3209-69_1"	"SL005437"	"MEPE"	"Matrix extracellular phosphoglycoprotein"	"4"	"87821411"	"87846817"	"MEPE"	"56955"	"Q9NQ76"	""	""	""	""	""	""	""	"Promotes renal phosphate excretion and modulates mineralization."	""	"TRUE"
"3210-1_2"	"SL010374"	"METAP1"	"Methionine aminopeptidase 1"	"4"	"98995620"	"99062813"	"METAP1"	"23173"	"P53582"	""	""	""	"Inactivation, recovery and regulation of the phototransduction cascade"	""	""	""	"Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle."	""	"TRUE"
"3212-30_3"	"SL010375"	"ASAH2"	"Neutral ceramidase"	"10"	"50182778"	"50248610"	"ASAH2"	"56624"	"Q9NR71"	""	""	""	"Glycosphingolipid metabolism"	""	""	""	"Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. Probably involved in the digestion of dietary sphingolipids in intestine by acting as a key enzyme for the catabolism of dietary sphingolipids and regulating the levels of bioactive sphingolipid metabolites in the intestinal tract."	"116|344|361"	"TRUE"
"3213-65_2"	"SL000640"	"Nidogen"	"Nidogen-1"	"1"	"235975830"	"236065162"	"NID1"	"4811"	"P14543"	""	"Beta1 integrin cell surface interactions"	""	"Degradation of the extracellular matrix|Laminin interactions"	""	""	""	"Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions."	"298"	"TRUE"
"3214-3_2"	"SL006397"	"NRP1"	"Neuropilin-1"	"10"	"33177492"	"33336262"	"NRP1"	"8829"	"O14786"	"NA"	"NA"	"NA"	"NA"	"NA"	""	"diagnosis|efficacy"	"The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis."	""	"TRUE"
"3216-2_2"	"SL005797"	"PIGR"	"Polymeric immunoglobulin receptor"	"1"	"206928518"	"206946466"	"PIGR"	"5284"	"P01833"	"Integrated Breast Cancer Pathway"	"IL4-mediated signaling events"	""	""	""	""	"unspecified application"	"This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment."	"401"	"TRUE"
"3217-74_2"	"SL004457"	"Protease nexin I"	"Glia-derived nexin"	"2"	"223975112"	"224039319"	"SERPINE2"	"5270"	"P07093"	"Epithelium TarBase|Leukocyte TarBase|Lymphocyte TarBase"	""	""	"Common Pathway of Fibrin Clot Formation|Dissolution of Fibrin Clot|Intrinsic Pathway of Fibrin Clot Formation"	""	""	""	"Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin."	""	"TRUE"
"3218-8_2"	"SL000158"	"PSMA"	"Glutamate carboxypeptidase 2"	"11"	"49146635"	"49208670"	"FOLH1"	"2346"	"Q04609"	"NA"	"NA"	"NA"	"NA"	"NA"	"capromab pendetide"	"efficacy|prognosis"	"Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression."	""	"TRUE"
"3220-40_2"	"SL010378"	"RET"	"Proto-oncogene tyrosine-protein kinase receptor Ret"	"10"	"43077027"	"43130351"	"RET"	"5979"	"P07949"	"SIDS Susceptibility Pathways"	"Posttranslational regulation of adherens junction stability and dissassembly|Signaling events regulated by Ret tyrosine kinase"	""	""	"GDNF -> HSF1 signaling|GFs/TNF -> ion channels|Regulation of calcium flux"	"sunitinib|motesanib|cabozantinib|regorafenib|ponatinib|bortezomib/sorafenib|dexamethasone/lenalidomide/sorafenib|bevacizumab/sorafenib|imatinib/sirolimus|cabozantinib/erlotinib|imatinib/nilotinib/pegintron|imatinib|sorafenib|vandetanib"	"efficacy|response to therapy"	"Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell migration."	"207|294|414"	"TRUE"
"3221-54_1"	"SL003770"	"SARP-2"	"Secreted frizzled-related protein 1"	"8"	"41261958"	"41309497"	"SFRP1"	"6422"	"Q8N474"	""	"Validated targets of C-MYC transcriptional repression"	""	"negative regulation of TCF-dependent signaling by WNT ligand antagonists"	""	""	"diagnosis|prognosis"	"Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription."	""	"TRUE"
"3222-11_2"	"SL010379"	"Semaphorin 3A"	"Semaphorin-3A"	"7"	"83955777"	"84492724"	"SEMA3A"	"10371"	"Q14563"	"angiogenesis overview"	""	""	"CRMPs in Sema3A signaling|SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion|Sema3A PAK dependent Axon repulsion"	""	""	""	"Involved in the development of the olfactory system and in neuronal control of puberty. Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1."	"31|82"	"TRUE"
"3232-28_2"	"SL004118"	"TrATPase"	"Tartrate-resistant acid phosphatase type 5"	"19"	"11574660"	"11579008"	"ACP5"	"54"	"P13686"	"Osteoclast Signaling|RANKL/RANK Signaling Pathway"	""	""	"Vitamin B2 (riboflavin) metabolism"	""	""	"disease progression|efficacy|unspecified application"	"Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias."	""	"TRUE"
"3234-23_2"	"SL010390"	"URB"	"Coiled-coil domain-containing protein 80"	"3"	"112596794"	"112649530"	"CCDC80"	"151887"	"Q76M96"	""	""	""	""	""	""	""	"Promotes cell adhesion and matrix assembly."	""	"TRUE"
"3235-50_2"	"SL010391"	"WFKN2"	"WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2"	"17"	"50834650"	"50842348"	"WFIKKN2"	"124857"	"Q8TEU8"	""	""	""	""	""	""	""	"Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity. Inhibits the biological activity of mature myostatin, but not activin (By similarity)."	"94"	"TRUE"
"3280-49_2"	"SL004661"	"Aggrecan"	"Aggrecan core protein"	"15"	"88803443"	"88875354"	"ACAN"	"176"	"P16112"	"Endochondral Ossification"	""	""	"Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)|Defective CHST6 causes MCDC1|Degradation of the extracellular matrix|ECM proteoglycans|Keratan sulfate biosynthesis|Keratan sulfate degradation"	""	""	"unspecified application"	"This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region."	""	"TRUE"
"3281-19_1"	"SL006803"	"ANGL3"	"Angiopoietin-related protein 3"	"1"	"62597487"	"62606159"	"ANGPTL3"	"27329"	"Q9Y5C1"	""	"Integrins in angiogenesis"	""	""	""	""	""	"Interacts with ANGPTL8."	""	"TRUE"
"3283-21_1"	"SL006544"	"BGH3"	"Transforming growth factor-beta-induced protein ig-h3"	"5"	"136028895"	"136063818"	"TGFBI"	"7045"	"Q15582"	""	"Beta1 integrin cell surface interactions|Beta2 integrin cell surface interactions|Beta3 integrin cell surface interactions"	""	"Amyloids"	""	""	""	"Binds to type I, II, and IV collagens. This adhesion protein may play an important role in cell-collagen interactions. In cartilage, may be involved in endochondral bone formation."	"135"	"TRUE"
"3284-75_1"	"SL007804"	"BGN"	"Biglycan"	"X"	"153494939"	"153509554"	"BGN"	"633"	"P21810"	""	"Endogenous TLR signaling"	""	"A tetrasaccharide linker sequence is required for GAG synthesis|CS/DS degradation|Chondroitin sulfate biosynthesis|Defective B3GAT3 causes JDSSDHD|Defective B4GALT7 causes EDS, progeroid type|Defective CHST14 causes EDS, musculocontractural type|Defective CHST3 causes SEDCJD|Defective CHSY1 causes TPBS|Dermatan sulfate biosynthesis|ECM proteoglycans"	""	""	""	"May be involved in collagen fiber assembly."	""	"TRUE"
"3285-23_2"	"SL000310"	"C1r"	"Complement C1r subcomponent"	"12"	"7080209"	"7092607"	"C1R"	"715"	"P00736"	""	""	""	"Classical antibody-mediated complement activation|Initial triggering of complement"	"Classical Complement Pathway"	"SERPING1"	""	"C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system."	"115"	"TRUE"
"3289-19_2"	"SL010449"	"Carbonic Anhydrase X"	"Carbonic anhydrase-related protein 10"	"17"	"51630313"	"52160017"	"CA10"	"56934"	"Q9NS85"	""	""	""	""	""	""	""	"Does not have a catalytic activity."	""	"TRUE"
"3290-50_2"	"SL008773"	"CD109"	"CD109 antigen"	"6"	"73695785"	"73828316"	"CD109"	"135228"	"Q6YHK3"	""	""	""	""	""	""	""	"Modulates negatively TGFB1 signaling in keratinocytes."	"28|69|85"	"TRUE"
"3291-30_2"	"SL002706"	"CD23"	"Low affinity immunoglobulin epsilon Fc receptor"	"19"	"7688758"	"7702146"	"FCER2"	"2208"	"P06734"	""	"IL4-mediated signaling events"	""	"NOTCH2 intracellular domain regulates transcription"	""	""	"diagnosis"	"Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen)."	"310"	"TRUE"
"3292-75_1"	"SL010450"	"CD48"	"CD48 antigen"	"1"	"160678746"	"160711851"	"CD48"	"962"	"P09326"	""	""	""	"Cell surface interactions at the vascular wall"	"Natural Killer Cell Activation|Natural Killer Cell Activation through ITSM-Containing Receptors|Natural Killer Cell Activation through Integrins and non-ITAM-Containing Receptors"	""	""	"Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation."	""	"TRUE"
"3293-2_4"	"SL006108"	"CD5L"	"CD5 antigen-like"	"1"	"157830914"	"157898256"	"CD5L"	"922"	"O43866"	""	""	""	""	""	""	""	"Secreted protein that acts as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflammed tissues and regulates mechanisms in inflammatory responses, such as infection or atherosclerosis. Able to inhibit lipid droplet size in adipocytes. Following incorporation into mature adipocytes via CD36-mediated endocytosis, associates with cytosolic FASN, inhibiting fatty acid synthase activity and leading to lipolysis, the degradation of triacylglycerols into glycerol and free fatty acids (FFA). CD5L-induced lipolysis occurs with progression of obesity: participates to obesity-associated inflammation following recruitment of inflammatory macrophages into adipose tissues, a cause of insulin resistance and obesity-related metabolic disease. Regulation of intracellular lipids mediated by CD5L has a direct effect on transcription regulation mediated by nuclear receptors ROR-gamma (RORC). Acts as a key regulator of metabolic switch in T-helper Th17 cells. Regulates the expression of pro-inflammatory genes in Th17 cells by altering the lipid content and limiting synthesis of cholesterol ligand of RORC, the master transcription factor of Th17-cell differentiation. CD5L is mainly present in non-pathogenic Th17 cells, where it decreases the content of polyunsaturated fatty acyls (PUFA), affecting two metabolic proteins MSMO1 and CYP51A1, which synthesize ligands of RORC, limiting RORC activity and expression of pro-inflammatory genes. Participates in obesity-associated autoimmunity via its association with IgM, interfering with the binding of IgM to Fcalpha/mu receptor and enhancing the development of long-lived plasma cells that produce high-affinity IgG autoantibodies (By similarity). Also acts as an inhibitor of apoptosis in macrophages: promotes macrophage survival from the apoptotic effects of oxidized lipids in case of atherosclerosis (PubMed:24295828). Involved in early response to microbial infection against various pathogens by acting as a pattern recognition receptor and by promoting autophagy (PubMed:16030018, PubMed:24223991, PubMed:24583716, PubMed:25713983)."	""	"TRUE"
"3294-55_2"	"SL010451"	"CFC1"	"Cryptic protein"	"2"	"130592168"	"130599575"	"CFC1"	"55997"	"P0CG37"	""	""	""	"Regulation of signaling by NODAL|Signaling by NODAL"	""	""	""	"NODAL coreceptor involved in the correct establishment of the left-right axis. May play a role in mesoderm and/or neural patterning during gastrulation."	""	"TRUE"
"3296-92_2"	"SL008623"	"CNTN2"	"Contactin-2"	"1"	"205043197"	"205078499"	"CNTN2"	"6900"	"Q02246"	""	""	""	"L1CAM interactions|NCAM1 interactions|NrCAM interactions"	""	""	""	"In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region. May be involved in cell adhesion."	"102|364|432|434"	"TRUE"
"3298-52_2"	"SL010454"	"Contactin-4"	"Contactin-4"	"3"	"2098813"	"3057956"	"CNTN4"	"152330"	"Q8IWV2"	""	""	""	""	""	""	""	"Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis."	""	"TRUE"
"3299-29_2"	"SL010455"	"Contactin-5"	"Contactin-5"	"11"	"99020953"	"100358885"	"CNTN5"	"53942"	"O94779"	""	""	""	""	""	""	""	"Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons. Probably involved in neuronal activity in the auditory system (By similarity)."	"220"	"TRUE"
"3302-58_1"	"SL007049"	"CYTF"	"Cystatin-F"	"20"	"24949230"	"24959928"	"CST7"	"8530"	"O76096"	""	""	""	""	""	""	""	"Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system."	"70|405"	"TRUE"
"3303-23_2"	"SL004438"	"Cystatin M"	"Cystatin-M"	"11"	"66011841"	"66013505"	"CST6"	"1474"	"Q15828"	""	""	""	""	""	""	"diagnosis"	"Shows moderate inhibition of cathepsin B but is not active against cathepsin C."	""	"TRUE"
"3305-6_1"	"SL010457"	"DLL4"	"Delta-like protein 4"	"15"	"40929340"	"40939072"	"DLL4"	"54567"	"Q9NR61"	"Neural Crest Differentiation|Notch Signaling Pathway"	"Notch signaling pathway"	""	"Activated NOTCH1 Transmits Signal to the Nucleus|Constitutive Signaling by NOTCH1 HD Domain Mutants|Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants|Constitutive Signaling by NOTCH1 PEST Domain Mutants|Constitutive Signaling by NOTCH1 t(7|NOTCH2 Activation and Transmission of Signal to the Nucleus|Signaling by NOTCH3|Signaling by NOTCH4"	"Notch -> EP300/ASCL signaling|Notch -> LEF1 signaling|Notch -> MEF/MYOD signaling|Notch -> NF-kB signaling|Notch -> SMAD3 signaling|Notch -> TCF3 signaling"	"OMP-21M18|REGN421"	""	"Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation is required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate."	""	"TRUE"
"3310-62_1"	"SL017613"	"FCG2A/B"	"Low affinity immunoglobulin gamma Fc region receptor II-a/b"	"1"	"161505430"	"161678654"	"FCGR2A|FCGR2B"	"NA"	"P12318|P31994"	""	"BCR signaling pathway|Fc-epsilon receptor I signaling in mast cells"	""	"Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"	"T-cell-Independent B-cell Activation"	""	""	"Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.|Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis."	"10|16|141|240|266"	"TRUE"
"3311-27_1"	"SL008609"	"FCG3B"	"Low affinity immunoglobulin gamma Fc region receptor III-B"	"1"	"161623196"	"161631963"	"FCGR3B"	"2215"	"O75015"	""	""	""	""	"Natural Killer Cell Activation through ITAM-Containing Receptors"	"IgG"	""	"Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils."	"141"	"TRUE"
"3312-64_1"	"SL010461"	"FCGR1"	"High affinity immunoglobulin gamma Fc receptor I"	"1"	"149782671"	"149792518"	"FCGR1A"	"2209"	"P12314"	""	""	""	"Cross-presentation of soluble exogenous antigens (endosomes)|FCGR activation|Interferon gamma signaling|Regulation of actin dynamics for phagocytic cup formation|Role of phospholipids in phagocytosis"	""	"IgG"	""	"High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses."	""	"TRUE"
"3313-21_2"	"SL006542"	"FCN2"	"Ficolin-2"	"9"	"134880812"	"134887520"	"FCN2"	"2220"	"Q15485"	""	""	""	"Ficolins bind to repetitive carbohydrate structures on the target cell surface|Initial triggering of complement|Lectin pathway of complement activation"	""	""	""	"May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region."	"331"	"TRUE"
"3314-74_2"	"SL004858"	"GFRa-1"	"GDNF family receptor alpha-1"	"10"	"116056925"	"116273467"	"GFRA1"	"2674"	"P56159"	"Diurnally regulated genes with circadian orthologs"	"Posttranslational regulation of adherens junction stability and dissassembly|Signaling events regulated by Ret tyrosine kinase"	""	"NCAM1 interactions"	"GDNF -> HSF1 signaling|GFs/TNF -> ion channels|Regulation of calcium flux"	""	""	"Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity)."	""	"TRUE"
"3315-15_1"	"SL010463"	"GPC2"	"Glypican-2"	"7"	"100169606"	"100177372"	"GPC2"	"221914"	"Q8N158"	""	"Glypican 2 network|Glypican pathway"	""	"A tetrasaccharide linker sequence is required for GAG synthesis|Defective B3GAT3 causes JDSSDHD|Defective B4GALT7 causes EDS, progeroid type|Defective EXT1 causes exostoses 1, TRPS2 and CHDS|Defective EXT2 causes exostoses 2|HS-GAG biosynthesis|HS-GAG degradation|Retinoid metabolism and transport"	""	""	""	"Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons (By similarity)."	""	"TRUE"
"3316-58_1"	"SL004466"	"Heparin cofactor II"	"Heparin cofactor 2"	"22"	"20773879"	"20787720"	"SERPIND1"	"3053"	"P05546"	"Complement and Coagulation Cascades"	""	""	"Common Pathway of Fibrin Clot Formation|Intrinsic Pathway of Fibrin Clot Formation"	""	"ardeparin|glucuronyl glucosamine glycan sulfate"	"disease progression"	"Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner."	"46|86"	"TRUE"
"3317-33_1"	"SL004860"	"HTRA2"	"Serine protease HTRA2, mitochondrial"	"2"	"74529377"	"74533348"	"HTRA2"	"27429"	"O43464"	"Apoptosis Modulation and Signaling"	""	""	""	"Apoptosis"	""	""	"Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive."	""	"TRUE"
"3320-49_2"	"SL005087"	"IGFBP-7"	"Insulin-like growth factor-binding protein 7"	"4"	"57030773"	"57110385"	"IGFBP7"	"3490"	"Q16270"	"Senescence and Autophagy"	""	""	"Senescence-Associated Secretory Phenotype (SASP)"	""	""	""	"Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion."	"239"	"TRUE"
"3321-2_2"	"SL007385"	"IL24"	"Interleukin-24"	"1"	"206897443"	"206904139"	"IL24"	"11009"	"Q13007"	"Senescence and Autophagy"	"IL23-mediated signaling events"	""	""	""	""	""	"Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation."	""	"TRUE"
"3322-52_2"	"SL010464"	"LRIG3"	"Leucine-rich repeats and immunoglobulin-like domains protein 3"	"12"	"58872149"	"58920522"	"LRIG3"	"121227"	"Q6UXM1"	""	""	""	""	""	""	""	"May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity)."	""	"TRUE"
"3323-37_1"	"SL004610"	"LRP8"	"Low-density lipoprotein receptor-related protein 8"	"1"	"53242364"	"53328070"	"LRP8"	"7804"	"Q14114"	""	"Lissencephaly gene (LIS1) in neuronal migration and development|Reelin signaling pathway"	""	"Platelet sensitization by LDL|Retinoid metabolism and transport"	""	""	""	"Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor."	""	"TRUE"
"3324-51_1"	"SL007674"	"LY9"	"T-lymphocyte surface antigen Ly-9"	"1"	"160796074"	"160828261"	"LY9"	"4063"	"Q9HBG7"	""	""	""	""	""	""	""	"Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion by CD4(+) T-cells. May negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells (By similarity)."	"196"	"TRUE"
"3325-2_2"	"SL010465"	"MATN2"	"Matrilin-2"	"8"	"97868840"	"98036716"	"MATN2"	"4147"	"O00339"	""	""	""	""	""	""	""	"Involved in matrix assembly."	""	"TRUE"
"3326-58_2"	"SL004805"	"Nectin-like protein 2"	"Cell adhesion molecule 1"	"11"	"115169218"	"115504957"	"CADM1"	"23705"	"Q9BY67"	""	""	""	""	""	""	""	"Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa."	""	"TRUE"
"3327-27_1"	"SL007673"	"NET4"	"Netrin-4"	"12"	"95657807"	"95791152"	"NTN4"	"59277"	"Q9HB63"	""	""	""	"Netrin-1 signaling|Non-integrin membrane-ECM interactions"	""	""	""	"May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants."	""	"TRUE"
"3329-14_2"	"SL004515"	"PGRP-S"	"Peptidoglycan recognition protein 1"	"19"	"46019153"	"46023065"	"PGLYRP1"	"8993"	"O75594"	""	""	""	""	""	""	""	"Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity."	""	"TRUE"
"3331-8_1"	"SL010468"	"RGMB"	"RGM domain family member B"	"5"	"98768650"	"98798643"	"RGMB"	"285704"	"Q6NW40"	""	"BMP receptor signaling"	""	"Netrin-1 signaling"	""	""	""	"Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth."	""	"TRUE"
"3332-57_1"	"SL010469"	"RGM-C"	"Hemojuvelin"	"1"	"146017468"	"146021918"	"HFE2"	"148738"	"Q6ZVN8"	""	"BMP receptor signaling"	""	"Netrin-1 signaling"	""	""	""	"Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis."	"312"	"TRUE"
"3336-50_1"	"SL001998"	"TFPI"	"Tissue factor pathway inhibitor"	"2"	"187464230"	"187565760"	"TFPI"	"7035"	"P10646"	"Complement and Coagulation Cascades|Integrated Breast Cancer Pathway"	"Syndecan-4-mediated signaling events"	""	"Extrinsic Pathway of Fibrin Clot Formation"	"Coagulation Cascade"	"dalteparin"	""	"Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma."	""	"TRUE"
"3339-33_1"	"SL007206"	"TSP2"	"Thrombospondin-2"	"6"	"169215780"	"169254044"	"THBS2"	"7058"	"P35442"	"Focal Adhesion"	"Alpha4 beta1 integrin signaling events|Beta1 integrin cell surface interactions"	""	"O-glycosylation of TSR domain-containing proteins|Signaling by PDGF"	"Extracellular Matrix Turnover"	""	""	"Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties."	"213"	"TRUE"
"3340-53_1"	"SL007207"	"TSP4"	"Thrombospondin-4"	"5"	"79991311"	"80083287"	"THBS4"	"7060"	"P35443"	"Focal Adhesion|Inflammatory Response Pathway"	""	""	"Signaling by PDGF"	""	""	"diagnosis"	"Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner (By similarity)."	""	"TRUE"
"3341-33_4"	"SL006892"	"ABL1"	"Tyrosine-protein kinase ABL1"	"9"	"130713946"	"130887675"	"ABL1"	"25"	"P00519"	"Cell cycle|DNA damage response|DNA damage response (only ATM dependent)|EGF/EGFR Signaling Pathway|ErbB signaling pathway|Integrated Breast Cancer Pathway|TP53 network|miRNA regulation of DNA Damage Response|miRNAs involved in DDR"	"ATM pathway|Lissencephaly gene (LIS1) in neuronal migration and development|Neurotrophic factor-mediated Trk receptor signaling|PDGFR-beta signaling pathway|Posttranslational regulation of adherens junction stability and dissassembly|Regulation of Telomerase|Regulation of retinoblastoma protein|Validated transcriptional targets of TAp63 isoforms|p53 pathway|p73 transcription factor network"	""	"CDO in myogenesis|Factors involved in megakaryocyte development and platelet production|RHO GTPases Activate WASPs and WAVEs|Regulation of actin dynamics for phagocytic cup formation|Role of Abl in Robo-Slit signaling"	"Natural Killer Cell Inhibitory Receptor Signaling|Telomere Maintenance"	"nilotinib|saracatinib|regorafenib|ponatinib|cyclophosphamide/daunorubicin/imatinib/prednisone/vincristine|imatinib/nilotinib/pegintron|bosutinib|imatinib|temozolomide"	"efficacy|response to therapy|unspecified application"	"Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1."	""	"TRUE"
"3343-1_4"	"SL005574"	"Aminoacylase-1"	"Aminoacylase-1"	"3"	"51983340"	"51989197"	"ACY1"	"95"	"Q03154"	"Urea cycle and metabolism of amino groups"	""	""	"Aflatoxin activation and detoxification|Defective ACY1 causes encephalopathy"	""	""	"unspecified application"	"Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate)."	""	"TRUE"
"3344-60_4"	"SL000272"	"Antithrombin III"	"Antithrombin-III"	"1"	"173903804"	"173917378"	"SERPINC1"	"462"	"P01008"	"Complement and Coagulation Cascades"	"Glypican 1 network"	""	"Common Pathway of Fibrin Clot Formation|Intrinsic Pathway of Fibrin Clot Formation"	"Coagulation Cascade"	"dalteparin|heparin|enoxaparin|ardeparin|SR-123781A|glucuronyl glucosamine glycan sulfate|fondaparinux|nadroparin"	"diagnosis|unspecified application"	"Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin."	""	"TRUE"
"3346-72_2"	"SL010520"	"AURKB"	"Aurora kinase B"	"17"	"8204733"	"8210600"	"AURKB"	"9212"	"Q96GD4"	"Epithelium TarBase|Lymphocyte TarBase"	"Aurora A signaling|Aurora B signaling|Aurora C signaling|FOXM1 transcription factor network|Signaling by Aurora kinases"	""	"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1|Mitotic Prometaphase|RHO GTPases Activate Formins|Resolution of Sister Chromatid Cohesion|Separation of Sister Chromatids"	"Cell Cycle|Chromosome Condensation|Histone Phosphorylation|Kinetochore Assembly|Microtubule Cytoskeleton Assembly|Sister Chromatid Cohesion|Spindle Assembly"	"barasertib|tozasertib|danusertib|GSK1070916"	""	"Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPT1, VIM/vimentin, GSG2/Haspin, and histone H3. A positive feedback loop involving GSG2 and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively). A positive feedback between GSG2 and AURKB contributes to CPC localization. AURKB is also required for kinetochore localization of BUB1 and SGOL1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity. Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes."	""	"TRUE"
"3347-9_2"	"SL002792"	"BARK1"	"beta-adrenergic receptor kinase 1"	"11"	"67266410"	"67286556"	"ADRBK1"	"156"	"P25098"	"Hedgehog Signaling Pathway"	"CXCR4-mediated signaling events|IL8- and CXCR1-mediated signaling events|Signaling events mediated by HDAC Class II|Signaling events mediated by the Hedgehog family|Thromboxane A2 receptor signaling"	""	"Activation of SMO|Calmodulin induced events|G alpha (q) signalling events"	""	""	""	"Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner."	""	"FALSE"
"3348-49_2"	"SL003994"	"BMP-1"	"Bone morphogenetic protein 1"	"8"	"22164736"	"22212326"	"BMP1"	"649"	"P13497"	"Adipogenesis"	""	""	"Anchoring fibril formation|Collagen biosynthesis and modifying enzymes|Crosslinking of collagen fibrils|Degradation of the extracellular matrix|HDL-mediated lipid transport"	""	""	"efficacy"	"Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). Responsible for the proteolytic activation of lysyl oxidase LOX."	""	"TRUE"
"3350-53_2"	"SL010491"	"CAMK2A"	"Calcium/calmodulin-dependent protein kinase type II subunit alpha"	"5"	"150219491"	"150290291"	"CAMK2A"	"815"	"Q9UQM7"	"B Cell Receptor Signaling Pathway|Calcium Regulation in the Cardiac Cell|EGF/EGFR Signaling Pathway|ErbB signaling pathway|Myometrial Relaxation and Contraction Pathways"	"FGF signaling pathway|IFN-gamma pathway|Netrin-mediated signaling events|Noncanonical Wnt signaling pathway|TGF-beta receptor signaling|Trk receptor signaling mediated by PI3K and PLC-gamma"	""	"CREB phosphorylation through the activation of CaMKII|CREB phosphorylation through the activation of Ras|Ca2+ pathway|HSF1-dependent transactivation|Interferon gamma signaling|Ras activation uopn Ca2+ infux through NMDA receptor|Trafficking of AMPA receptors|Unblocking of NMDA receptor, glutamate binding and activation"	"ADRA1 -> prostaglandin generation|CHRM1/2/3/5 -> ion channels|CNR1/2 -> vascular motility|EDNRA/B -> vascular motility|EPHB -> NMDA receptor activation|GFs/TNF -> ion channels|HRH1/2 -> vascular motility|HTR1 -> vascular motility|Regulation of calcium flux|Summarized vascular motility pathway"	""	""	"CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity)."	""	"TRUE"
"3351-1_1"	"SL010492"	"CAMK2B"	"Calcium/calmodulin-dependent protein kinase type II subunit beta"	"7"	"44217150"	"44334577"	"CAMK2B"	"816"	"Q13554"	"Calcium Regulation in the Cardiac Cell|Hypothetical Network for Drug Addiction|Myometrial Relaxation and Contraction Pathways"	"IFN-gamma pathway|Regulation of Ras family activation|p38 MAPK signaling pathway"	""	"CREB phosphorylation through the activation of CaMKII|CREB phosphorylation through the activation of Ras|HSF1-dependent transactivation|Interferon gamma signaling|Ras activation uopn Ca2+ infux through NMDA receptor|Trafficking of AMPA receptors|Unblocking of NMDA receptor, glutamate binding and activation"	""	""	""	"Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2."	""	"TRUE"
"3352-80_3"	"SL010288"	"Carbonic anhydrase 6"	"Carbonic anhydrase 6"	"1"	"8945867"	"8975092"	"CA6"	"765"	"P23280"	""	""	""	"Reversible hydration of carbon dioxide"	""	"methazolamide|hydrochlorothiazide|acetazolamide|trichloromethiazide|chlorothiazide|chlorthalidone|benzthiazide|sulfacetamide|topiramate"	""	"Reversible hydration of carbon dioxide. Its role in saliva is unknown."	"109|289|400"	"TRUE"
"3356-50_1"	"SL004868"	"Carbonic anhydrase VII"	"Carbonic anhydrase 7"	"16"	"66844379"	"66854153"	"CA7"	"766"	"P43166"	""	""	""	"Reversible hydration of carbon dioxide"	""	"ethoxyzolamide|dichlorphenamide|methazolamide|hydrochlorothiazide|acetazolamide|trichloromethiazide|chlorothiazide|chlorthalidone|benzthiazide|sulfacetamide|topiramate"	""	"Reversible hydration of carbon dioxide."	""	"TRUE"
"3357-67_2"	"SL010495"	"CDK2/cyclin A"	"Cyclin-dependent kinase 2:Cyclin-A2 complex"	"12|4"	"55966769|121816444"	"55972784|121823933"	"CDK2|CCNA2"	"1017|890"	"P24941|P20248"	"AMPK signaling|Cell cycle"	"ATF-2 transcription factor network|ATR signaling pathway|E2F transcription factor network|FOXM1 transcription factor network|IL2 signaling events mediated by STAT5|Regulation of retinoblastoma protein|Signaling events mediated by PRL|Validated transcriptional targets of AP1 family members Fra1 and Fra2|p53 pathway|p73 transcription factor network"	""	"Cdc20:Phospho-APC/C mediated degradation of Cyclin A|Cyclin A/B1 associated events during G2/M transition|Cyclin A:Cdk2-associated events at S phase entry|DNA Damage/Telomere Stress Induced Senescence|G0 and Early G1|G2 Phase|Orc1 removal from chromatin|Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes|Regulation of APC/C activators between G1/S and early anaphase|SCF(Skp2)-mediated degradation of p27/p21|Senescence-Associated Secretory Phenotype (SASP)"	"Cell Cycle"	""	""	"Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization. Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity).|Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions."	""	"TRUE"
"3358-51_2"	"SL010496"	"CDK5/p35"	"Cyclin-dependent kinase 5:Cyclin-dependent kinase 5 activator 1 complex"	"17|7"	"32486619|151053812"	"32491256|151058530"	"CDK5|CDK5R1"	"1020|8851"	"Q00535|Q15078"	"Alzheimers Disease|DNA damage response|Nicotine Activity on Dopaminergic Neurons|miRNA regulation of DNA Damage Response"	"EPHA forward signaling|Glucocorticoid receptor regulatory network|Lissencephaly gene (LIS1) in neuronal migration and development|Reelin signaling pathway|Trk receptor signaling mediated by the MAPK pathway"	""	"CRMPs in Sema3A signaling|DARPP-32 events|Factors involved in megakaryocyte development and platelet production"	""	""	""	"Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.|p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution."	""	"TRUE"
"3359-11_2"	"SL010522"	"CDK8/cyclin C"	"Cyclin-dependent kinase 8:Cyclin-C complex"	"13|6"	"26254104|99542380"	"26405238|99568973"	"CDK8|CCNC"	"1024|892"	"P49336|P24863"	""	""	""	"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants|Constitutive Signaling by NOTCH1 PEST Domain Mutants|Generic Transcription Pathway|NOTCH1 Intracellular Domain Regulates Transcription|PPARA activates gene expression|SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription|Transcriptional regulation of white adipocyte differentiation"	"Cell Cycle"	""	""	"Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation.|Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex."	""	"TRUE"
"3360-50_4"	"SL003726"	"Chk2"	"Serine/threonine-protein kinase Chk2"	"22"	"28687743"	"28742422"	"CHEK2"	"11200"	"O96017"	"Cell cycle|DNA damage response|Integrated Breast Cancer Pathway|Integrated Cancer pathway|miRNA regulation of DNA Damage Response"	"ATM pathway|FOXM1 transcription factor network|PLK3 signaling events|p53 pathway"	""	"G2/M DNA damage checkpoint|Ubiquitin Mediated Degradation of Phosphorylated Cdc25A"	"Apoptosis|Cell Cycle"	""	""	"Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition (PubMed:25361978)."	""	"TRUE"
"3361-26_2"	"SL010610"	"CLC4K"	"C-type lectin domain family 4 member K"	"2"	"70830214"	"70835822"	"CD207"	"50489"	"Q9UJ71"	""	""	""	"Cross-presentation of soluble exogenous antigens (endosomes)"	""	""	""	"Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation."	""	"TRUE"
"3362-61_2"	"SL009400"	"CRDL1"	"Chordin-like protein 1"	"X"	"110673856"	"110795819"	"CHRDL1"	"91851"	"Q9BU40"	""	"BMP receptor signaling"	""	"Signaling by BMP"	""	""	""	"Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development."	""	"TRUE"
"3363-31_4"	"SL004781"	"CSK"	"Tyrosine-protein kinase CSK"	"15"	"74782057"	"74803198"	"CSK"	"1445"	"P41240"	"EGF/EGFR Signaling Pathway|Integrin-mediated cell adhesion|Regulation of Actin Cytoskeleton"	"BCR signaling pathway|CXCR4-mediated signaling events|PDGFR-beta signaling pathway|Signaling events mediated by PTP1B|TCR signaling in naïve CD4+ T cells|TCR signaling in naïve CD8+ T cells"	""	"GAB1 signalosome|Integrin alphaIIb beta3 signaling|PD-1 signaling|Phosphorylation of CD3 and TCR zeta chains"	"Natural Killer Cell Inhibitory Receptor Signaling|Transcytosis"	""	""	"Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK."	""	"FALSE"
"3364-76_2"	"SL006910"	"Cathepsin V"	"Cathepsin L2"	"9"	"97029679"	"97039643"	"CTSV"	"1515"	"O60911"	"Endochondral Ossification"	""	""	"Activation of Matrix Metalloproteinases|Assembly of collagen fibrils and other multimeric structures|Degradation of the extracellular matrix|Endosomal/Vacuolar pathway|MHC class II antigen presentation|Trafficking and processing of endosomal TLR"	""	""	""	"Cysteine protease. May have an important role in corneal physiology."	""	"TRUE"
"3365-7_2"	"SL010612"	"Dkk-4"	"Dickkopf-related protein 4"	"8"	"42374068"	"42377232"	"DKK4"	"27121"	"Q9UBT3"	""	"Regulation of nuclear beta catenin signaling and target gene transcription"	""	"TCF dependent signaling in response to WNT|misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling|negative regulation of TCF-dependent signaling by WNT ligand antagonists"	""	""	""	"Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity)."	"208|212"	"TRUE"
"3366-51_2"	"SL006550"	"ECM1"	"Extracellular matrix protein 1"	"1"	"150508062"	"150513789"	"ECM1"	"1893"	"Q16610"	""	""	""	""	""	""	"diagnosis"	"Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity."	"24|374"	"TRUE"
"3367-8_3"	"SL006777"	"FETUB"	"Fetuin-B"	"3"	"186635969"	"186653141"	"FETUB"	"26998"	"Q9UGM5"	""	""	""	""	""	""	""	"Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening (By similarity)."	"274"	"TRUE"
"3373-5_2"	"SL004654"	"Granzyme H"	"Granzyme H"	"14"	"24606480"	"24609699"	"GZMH"	"2999"	"P20718"	""	""	""	"Metabolism of Angiotensinogen to Angiotensins|Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"	""	""	""	"Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication."	""	"TRUE"
"3374-49_2"	"SL010499"	"HCK"	"Tyrosine-protein kinase HCK"	"20"	"32052188"	"32101856"	"HCK"	"3055"	"P08631"	"Focal Adhesion|IL-3 Signaling Pathway|IL-6 signaling pathway"	"Alpha-synuclein signaling|CXCR4-mediated signaling events|Class I PI3K signaling events|EPHA forward signaling|Ephrin B reverse signaling|Glypican 1 network|IL6-mediated signaling events|IL8- and CXCR1-mediated signaling events|IL8- and CXCR2-mediated signaling events|PDGFR-beta signaling pathway|Regulation of p38-alpha and p38-beta|Signaling events mediated by PTP1B|Thromboxane A2 receptor signaling|amb2 Integrin signaling"	""	"FCGR activation|Nef and signal transduction|Regulation of signaling by CBL"	"MacrophageR -> CEBPB/NF-kB signaling"	"bosutinib"	""	"Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS."	""	"TRUE"
"3376-49_2"	"SL010613"	"IL-17 RD"	"Interleukin-17 receptor D"	"3"	"57089982"	"57170306"	"IL17RD"	"54756"	"Q8NFM7"	""	"FGF signaling pathway"	""	"Signaling by FGFR1|Signaling by FGFR2|Signaling by FGFR3|Signaling by FGFR4"	""	""	""	"Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK. Mediates JNK activation and may be involved in apoptosis. Might have a role in the early stages of fate specification of GnRH-secreting neurons (By similarity)."	"89"	"TRUE"
"3378-49_2"	"SL000064"	"Kallikrein 7"	"Kallikrein-7"	"19"	"50976482"	"50984099"	"KLK7"	"5650"	"P49862"	""	""	""	"Degradation of the extracellular matrix"	""	""	"diagnosis"	"May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines."	"265"	"TRUE"
"3379-29_1"	"SL007228"	"KPCI"	"Protein kinase C iota type"	"3"	"170222365"	"170305981"	"PRKCI"	"5584"	"P41743"	"EGF/EGFR Signaling Pathway|Epithelium TarBase|G Protein Signaling Pathways|Insulin Signaling|Lymphocyte TarBase|Muscle cell TarBase|Wnt Signaling Pathway|Wnt Signaling Pathway and Pluripotency|miRs in Muscle Cell Differentiation"	"IL1-mediated signaling events|Insulin Pathway|Insulin-mediated glucose transport|Nephrin/Neph1 signaling in the kidney podocyte|Neurotrophic factor-mediated Trk receptor signaling|Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)|TNF receptor signaling pathway|p75(NTR)-mediated signaling"	""	"Tight junction interactions|p75NTR recruits signalling complexes"	""	"ingenol mebutate"	"unspecified application"	"Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis."	""	"TRUE"
"3381-24_2"	"SL010500"	"LYNB"	"Tyrosine-protein kinase Lyn, isoform B"	"8"	"55879813"	"56014168"	"LYN"	"4067"	"P07948"	"B Cell Receptor Signaling Pathway|IL-3 Signaling Pathway|IL-5 signaling pathway|Kit receptor signaling pathway|RANKL/RANK Signaling Pathway"	"Alpha-synuclein signaling|BCR signaling pathway|CXCR4-mediated signaling events|Class I PI3K signaling events|EPHA forward signaling|EPO signaling pathway|Ephrin B reverse signaling|Fc-epsilon receptor I signaling in mast cells|GMCSF-mediated signaling events|Glypican 1 network|IL5-mediated signaling events|IL8- and CXCR1-mediated signaling events|IL8- and CXCR2-mediated signaling events|LPA receptor mediated events|PDGFR-beta signaling pathway|Regulation of p38-alpha and p38-beta|Signaling events mediated by PTP1B|Signaling events mediated by Stem cell factor receptor (c-Kit)|Thromboxane A2 receptor signaling|amb2 Integrin signaling"	""	"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers|CD209 (DC-SIGN) signaling|CD28 co-stimulation|CTLA4 inhibitory signaling|Cell surface interactions at the vascular wall|Dectin-2 family|EPH-Ephrin signaling|EPH-ephrin mediated repulsion of cells|EPHA-mediated growth cone collapse|EPHB-mediated forward signaling|FCERI mediated Ca+2 mobilization|FCERI mediated MAPK activation|FCERI mediated NF-kB activation|FCGR activation|Fc epsilon receptor (FCERI) signaling|GPVI-mediated activation cascade|Growth hormone receptor signaling|PECAM1 interactions|Platelet Adhesion to exposed collagen|Regulation of KIT signaling|Regulation of signaling by CBL|Role of LAT2/NTAL/LAB on calcium mobilization|Signaling by SCF-KIT"	"B-cell receptor -> AP-1 signaling|B-cell receptor -> NF-kB signaling|B-cell receptor -> NFATC signaling|CD19 ->  AP-1/ELK-SRF signaling|CD19 -> NF-kB signaling|IL7R -> FOXO/NF-kB signaling|Natural Killer Cell Inhibitory Receptor Signaling|T-cell receptor -> AP-1 signaling|T-cell receptor -> ATF/CREB signaling|T-cell receptor -> CREBBP signaling|T-cell receptor -> NF-kB signaling|T-cell receptor -> NFATC signaling|T-cell-Dependent B-cell Activation|T-cell-Independent B-cell Activation|V(D)J Recombination Activation"	"nintedanib|bosutinib"	""	"Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, PTK2B/PYK2, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation."	""	"TRUE"
"3387-1_2"	"SL010508"	"PAK3"	"Serine/threonine-protein kinase PAK 3"	"X"	"110944285"	"111227361"	"PAK3"	"5063"	"O75914"	"Focal Adhesion|G13 Signaling Pathway|Integrin-mediated cell adhesion|Regulation of Actin Cytoskeleton"	"Regulation of p38-alpha and p38-beta"	""	"Activation of Rac|CD209 (DC-SIGN) signaling|CD28 dependent Vav1 pathway|Ephrin signaling|FCERI mediated MAPK activation|Generation of second messenger molecules|RHO GTPases activate PAKs|Sema3A PAK dependent Axon repulsion|VEGFR2 mediated vascular permeability"	""	""	""	"Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development."	""	"TRUE"
"3388-58_2"	"SL010510"	"PAK7"	"Serine/threonine-protein kinase PAK 7"	"20"	"9537389"	"9839041"	"PAK7"	"57144"	"Q9P286"	"Focal Adhesion|Regulation of Actin Cytoskeleton"	""	""	"Activation of Rac"	""	""	""	"Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions."	""	"TRUE"
"3389-7_2"	"SL000550"	"PCI"	"Plasma serine protease inhibitor"	"14"	"94561442"	"94593120"	"SERPINA5"	"5104"	"P05154"	"Complement and Coagulation Cascades"	""	""	"Common Pathway of Fibrin Clot Formation|Intrinsic Pathway of Fibrin Clot Formation"	""	""	"diagnosis"	"Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coagulation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue- and urinary-type plasminogen activators. In seminal plasma, inactivates several serine proteases implicated in the reproductive system. Inhibits the serpin acrosin; indirectly protects component of the male genital tract from being degraded by excessive released acrosin. Inhibits tissue-and urinary-type plasminogen activator, prostate-specific antigen and kallikrein activities; has a control on the sperm motility and fertilization. Inhibits the activated protein C-catalyzed degradation of SEMG1 and SEMG2; regulates the degradation of semenogelin during the process of transfer of spermatozoa from the male reproductive tract into the female tract. In urine, inhibits urinary-type plasminogen activator and kallikrein activities. Inactivates membrane-anchored serine proteases activities such as MPRSS7 and TMPRSS11E. Inhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. May also play a non-inhibitory role in seminal plasma and urine as a hydrophobic hormone carrier by its binding to retinoic acid."	""	"TRUE"
"3390-72_2"	"SL010512"	"PIK3CA/PIK3R1"	"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform:Phosphatidylinositol 3-kinase regulatory subunit alpha complex"	"3|5"	"179148114|68215720"	"179240093|68301821"	"PIK3CA|PIK3R1"	"5290|5295"	"P42336|P27986"	"AMPK signaling|Alpha 6 Beta 4 signaling pathway|Androgen receptor signaling pathway|Apoptosis|B Cell Receptor Signaling Pathway|EGF/EGFR Signaling Pathway|Focal Adhesion|IL-1 signaling pathway|IL-2 Signaling pathway|IL-3 Signaling Pathway|IL-4 signaling pathway|IL-5 signaling pathway|IL-6 signaling pathway|IL-7 signaling pathway|IL-9 signaling pathway|Insulin Signaling|Kit receptor signaling pathway|Leptin signaling pathway|MicroRNAs in cardiomyocyte hypertrophy|Notch Signaling Pathway|Prolactin Signaling Pathway|RANKL/RANK Signaling Pathway|Regulation of Actin Cytoskeleton|Regulation of toll-like receptor signaling pathway|TCR Signaling Pathway|TGF beta Signaling Pathway|TSH signaling pathway|Toll-like receptor signaling pathway"	"Angiopoietin receptor Tie2-mediated signaling|Atypical NF-kappaB pathway|BCR signaling pathway|CDC42 signaling events|CXCR3-mediated signaling events|CXCR4-mediated signaling events|Class I PI3K signaling events|E-cadherin signaling in keratinocytes|E-cadherin signaling in the nascent adherens junction|EGF receptor (ErbB1) signaling pathway|EPHA2 forward signaling|EPHB forward signaling|EPO signaling pathway|Ephrin B reverse signaling|ErbB1 downstream signaling|ErbB2/ErbB3 signaling events|ErbB4 signaling events|FAS (CD95) signaling pathway|FGF signaling pathway|Fc-epsilon receptor I signaling in mast cells|GMCSF-mediated signaling events|IFN-gamma pathway|IGF1 pathway|IL1-mediated signaling events|IL2 signaling events mediated by PI3K|IL2 signaling events mediated by STAT5|IL2-mediated signaling events|IL23-mediated signaling events|IL3-mediated signaling events|IL4-mediated signaling events|IL5-mediated signaling events|IL6-mediated signaling events|Insulin Pathway|Integrins in angiogenesis|Internalization of ErbB1|LPA receptor mediated events|N-cadherin signaling events|Nectin adhesion pathway|Nephrin/Neph1 signaling in the kidney podocyte|Netrin-mediated signaling events|Neurotrophic factor-mediated Trk receptor signaling|Nongenotropic Androgen signaling|Osteopontin-mediated events|PAR1-mediated thrombin signaling events|PDGFR-alpha signaling pathway|PDGFR-beta signaling pathway|Plasma membrane estrogen receptor signaling|Reelin signaling pathway|SHP2 signaling|Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)|Signaling events mediated by PTP1B|Signaling events mediated by Stem cell factor receptor (c-Kit)|Signaling events mediated by TCPTP|Signaling events mediated by VEGFR1 and VEGFR2|Signaling events mediated by focal adhesion kinase|Signaling events mediated by the Hedgehog family|Signaling events regulated by Ret tyrosine kinase|TRAIL signaling pathway|Trk receptor signaling mediated by PI3K and PLC-gamma|VEGFR1 specific signals|VEGFR3 signaling in lymphatic endothelium|a6b1 and a6b4 Integrin signaling|p75(NTR)-mediated signaling"	""	"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers|CD28 dependent PI3K/Akt signaling|Constitutive Signaling by Aberrant PI3K in Cancer|Constitutive Signaling by EGFRvIII|Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants|Costimulation by the CD28 family|DAP12 signaling|Downstream TCR signaling|Downstream signal transduction|G alpha (12/13) signalling events|G alpha (q) signalling events|G beta:gamma signalling through PI3Kgamma|GAB1 signalosome|GP1b-IX-V activation signalling|GPVI-mediated activation cascade|Interleukin receptor SHC signaling|Interleukin-3, 5 and GM-CSF signaling|Interleukin-7 signaling|Nephrin interactions|PI-3K cascade:FGFR1|PI-3K cascade:FGFR2|PI-3K cascade:FGFR3|PI-3K cascade:FGFR4|PI3K Cascade|PI3K events in ERBB2 signaling|PI3K events in ERBB4 signaling|PI3K/AKT activation|PIP3 activates AKT signaling|Regulation of signaling by CBL|Role of LAT2/NTAL/LAB on calcium mobilization|Role of phospholipids in phagocytosis|Signaling by FGFR1 fusion mutants|Signaling by FGFR1 mutants|Signaling by FGFR2 mutants|Signaling by FGFR3 mutants|Signaling by FGFR4 mutants|Signaling by SCF-KIT|Synthesis of PIPs at the plasma membrane|Tie2 Signaling|VEGFA-VEGFR2 Pathway"	"Peripheral T-cell Tolerance Overview"	""	""	"Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Also has serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS. Plays a role in the positive regulation of phagocytosis and pinocytosis (By similarity).|Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress-and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923)."	""	"TRUE"
"3391-10_2"	"SL007250"	"PK3CG"	"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform"	"7"	"106865278"	"106907145"	"PIK3CG"	"5294"	"P48736"	"AMPK signaling|B Cell Receptor Signaling Pathway|EPO Receptor Signaling|Focal Adhesion|IL-5 signaling pathway|Insulin Signaling|MicroRNAs in cardiomyocyte hypertrophy|Prolactin Signaling Pathway|Regulation of Actin Cytoskeleton|Regulation of toll-like receptor signaling pathway|Toll-like receptor signaling pathway"	"CXCR4-mediated signaling events|Class I PI3K signaling events|Class IB PI3K non-lipid kinase events|EPHA forward signaling|IL8- and CXCR1-mediated signaling events|IL8- and CXCR2-mediated signaling events|PDGFR-beta signaling pathway|Thromboxane A2 receptor signaling"	"phosphatidylinositol phosphate biosynthesis"	"G beta:gamma signalling through PI3Kgamma|GPVI-mediated activation cascade|Synthesis of PIPs at the plasma membrane"	"Endosomal Recycling"	"SF 1126|PX-866|dactolisib|GDC-0941|buparlisib|XL147"	""	"Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin-based adhesion at the leading edge. Controls motility of dendritic cells. Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in T-lymphocyte migration. Regulates T-lymphocyte proliferation and cytokine production. Together with PIK3CD participates in T-lymphocyte development. Required for B-lymphocyte development and signaling. Together with PIK3CD participates in neutrophil respiratory burst. Together with PIK3CD is involved in neutrophil chemotaxis and extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility. Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels. Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to ADRBK1 and by non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role in modulating cardiac contractility. Contributes to cardiac hypertrophy under pathological stress. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis."	""	"TRUE"
"3392-68_2"	"SL017614"	"PKB a/b/g"	"Protein kinase B alpha/beta/gamma"	"1|14|19"	"243488233|104769349|40230317"	"243855434|104795751|40285536"	"AKT1|AKT2|AKT3"	"207|208|10000"	"P31749|P31751|Q9Y243"	"AMPK signaling|Focal Adhesion|Insulin Signaling|Integrin-mediated cell adhesion|MAPK signaling pathway|MicroRNAs in cardiomyocyte hypertrophy|RANKL/RANK Signaling Pathway|Regulation of toll-like receptor signaling pathway|Signal Transduction of S1P Receptor|TFs Regulate miRNAs related to cardiac hypertrophy|TWEAK Signaling Pathway|Toll-like receptor signaling pathway"	"Class I PI3K signaling events mediated by Akt|E-cadherin signaling in keratinocytes|Insulin Pathway|Insulin-mediated glucose transport|Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)"	""	"AKT phosphorylates targets in the cytosol|AKT phosphorylates targets in the nucleus|AKT-mediated inactivation of FOXO1A|Activation of BAD and translocation to mitochondria|Activation of PKB|CD28 dependent PI3K/Akt signaling|CTLA4 inhibitory signaling|Constitutive Signaling by AKT1 E17K in Cancer|Downregulation of ERBB2:ERBB3 signaling|G beta:gamma signalling through PI3Kgamma|GPVI-mediated activation cascade|Inhibition of TSC complex formation by PKB|Negative regulation of the PI3K/AKT network|PDE3B signalling|PIP3 activates AKT signaling|TP53 Regulates Metabolic Genes|Translocation of GLUT4 to the plasma membrane|VEGFR2 mediated vascular permeability|deactivation of the beta-catenin transactivating complex"	"EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG signaling|IGF1R -> MEF/MYOD/MYOG signaling|VasopressinR1 -> MEF/MYOD/NFATC/MYOG signaling|VasopressinR2 -> MEF/MYOD/NFATC/MYOG signaling"	""	""	"AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1. AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis. Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis. Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity. The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). AKT mediates the antiapoptotic effects of IGF-I. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. May be involved in the regulation of the placental development. Phosphorylates STK4/MST1 at 'Thr-120' and 'Thr-387' leading to inhibition of its: kinase activity, nuclear translocation, autophosphorylation and ability to phosphorylate FOXO3. Phosphorylates STK3/MST2 at 'Thr-117' and 'Thr-384' leading to inhibition of its: cleavage, kinase activity, autophosphorylation at Thr-180, binding to RASSF1 and nuclear translocation. Phosphorylates SRPK2 and enhances its kinase activity towards SRSF2 and ACIN1 and promotes its nuclear translocation. Phosphorylates RAF1 at 'Ser-259' and negatively regulates its activity. Phosphorylation of BAD stimulates its pro-apoptotic activity. Phosphorylates KAT6A at 'Thr-369' and this phosphorylation inhibits the interaction of KAT6A with PML and negatively regulates its acetylation activity towards p53/TP53.|AKT2 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1. AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis. Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis. Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity. The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). AKT mediates the antiapoptotic effects of IGF-I. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. May be involved in the regulation of the placental development.|AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis."	""	"TRUE"
"3394-81_2"	"SL005258"	"PLK-1"	"Serine/threonine-protein kinase PLK1"	"16"	"23677656"	"23690367"	"PLK1"	"5347"	"P53350"	"Cell cycle|Epithelium TarBase|Integrated Breast Cancer Pathway|Integrated Cancer pathway|Lymphocyte TarBase|Muscle cell TarBase|Regulation of toll-like receptor signaling pathway|TNF alpha Signaling Pathway"	"ATR signaling pathway|FOXM1 transcription factor network|FoxO family signaling|PLK1 signaling events|Polo-like kinase signaling events in the cell cycle|Validated transcriptional targets of TAp63 isoforms|p73 transcription factor network"	""	"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1|Activation of NIMA Kinases NEK9, NEK6, NEK7|Anchoring of the basal body to the plasma membrane|Condensation of Prophase Chromosomes|Cyclin A/B1 associated events during G2/M transition|Golgi Cisternae Pericentriolar Stack Reorganization|Loss of Nlp from mitotic centrosomes|Loss of proteins required for interphase microtubule organization from the centrosome|Mitotic Metaphase/Anaphase Transition|Mitotic Prometaphase|Mitotic Telophase/Cytokinesis|Phosphorylation of Emi1|Phosphorylation of the APC/C|Polo-like kinase mediated events|RHO GTPases Activate Formins|Recruitment of mitotic centrosome proteins and complexes|Regulation of PLK1 Activity at G2/M Transition|Resolution of Sister Chromatid Cohesion|Separation of Sister Chromatids"	"Cell Cycle|Chromosome Condensation|Kinetochore Assembly|Sister Chromatid Cohesion|Spindle Assembly"	"BI 2536|volasertib"	"unspecified application"	"Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGOL1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1 and WEE1. Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL. NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. Phosphorylation of NINL component of the centrosome leads to NINL dissociation from other centrosomal proteins. Involved in mitosis exit and cytokinesis by phosphorylating CEP55, ECT2, KIF20A/MKLP2, CENPU, PRC1 and RACGAP1. Recruited at the central spindle by phosphorylating and docking PRC1 and KIF20A/MKLP2; creates its own docking sites on PRC1 and KIF20A/MKLP2 by mediating phosphorylation of sites subsequently recognized by the POLO box domains. Phosphorylates RACGAP1, thereby creating a docking site for the Rho GTP exchange factor ECT2 that is essential for the cleavage furrow formation. Promotes the central spindle recruitment of ECT2. Plays a central role in G2/M transition of mitotic cell cycle by phosphorylating CCNB1, CDC25C, FOXM1, CENPU, PKMYT1/MYT1, PPP1R12A/MYPT1 and WEE1. Part of a regulatory circuit that promotes the activation of CDK1 by phosphorylating the positive regulator CDC25C and inhibiting the negative regulators WEE1 and PKMYT1/MYT1. Also acts by mediating phosphorylation of cyclin-B1 (CCNB1) on centrosomes in prophase. Phosphorylates FOXM1, a key mitotic transcription regulator, leading to enhance FOXM1 transcriptional activity. Involved in kinetochore functions and sister chromatid cohesion by phosphorylating BUB1B/BUBR1, FBXO5/EMI1 and STAG2/SA2. PLK1 is high on non-attached kinetochores suggesting a role of PLK1 in kinetochore attachment or in spindle assembly checkpoint (SAC) regulation. Required for kinetochore localization of BUB1B. Regulates the dissociation of cohesin from chromosomes by phosphorylating cohesin subunits such as STAG2/SA2. Phosphorylates SGOL1: required for spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function. Mediates phosphorylation of FBXO5/EMI1, a negative regulator of the APC/C complex during prophase, leading to FBXO5/EMI1 ubiquitination and degradation by the proteasome. Acts as a negative regulator of p53 family members: phosphorylates TOPORS, leading to inhibit the sumoylation of p53/TP53 and simultaneously enhance the ubiquitination and subsequent degradation of p53/TP53. Phosphorylates the transactivation domain of the transcription factor p73/TP73, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Also required for recovery after DNA damage checkpoint and entry into mitosis. Phosphorylates MISP, leading to stabilization of cortical and astral microtubule attachments required for proper spindle positioning (PubMed:8991084, PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069). Together with MEIKIN, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage (By similarity). Phosphorylates CEP68 and is required for its degradation (PubMed:25503564)."	""	"TRUE"
"3396-54_2"	"SL000565"	"Renin"	"Renin"	"1"	"204154819"	"204166322"	"REN"	"5972"	"P00797"	"ACE Inhibitor Pathway"	""	""	"Metabolism of Angiotensinogen to Angiotensins"	""	"aliskiren|aliskiren/valsartan|aliskiren/amlodipine|aliskiren/amlodipine/hydrochlorothiazide|remikiren"	"efficacy"	"Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney."	""	"TRUE"
"3397-7_4"	"SL010616"	"SHP-2"	"Tyrosine-protein phosphatase non-receptor type 11"	"12"	"112418351"	"112509913"	"PTPN11"	"5781"	"Q06124"	"Alpha 6 Beta 4 signaling pathway|B Cell Receptor Signaling Pathway|EGF/EGFR Signaling Pathway|Heart Development|IL-1 signaling pathway|IL-2 Signaling pathway|IL-3 Signaling Pathway|IL-4 signaling pathway|IL-5 signaling pathway|IL-6 signaling pathway|Insulin Signaling|Kit receptor signaling pathway|Leptin signaling pathway|Prolactin Signaling Pathway|Proteins and DNA Sequences in Cardicac Structures|Signaling of Hepatocyte Growth Factor Receptor|TCR Signaling Pathway|Type II interferon signaling (IFNG)|angiogenesis overview"	"Angiopoietin receptor Tie2-mediated signaling|CXCR4-mediated signaling events|EGF receptor (ErbB1) signaling pathway|EPO signaling pathway|ErbB2/ErbB3 signaling events|FGF signaling pathway|Fc-epsilon receptor I signaling in mast cells|GMCSF-mediated signaling events|IFN-gamma pathway|IGF1 pathway|IL2 signaling events mediated by PI3K|IL2 signaling events mediated by STAT5|IL2-mediated signaling events|IL3-mediated signaling events|IL5-mediated signaling events|IL6-mediated signaling events|Insulin Pathway|Integrins in angiogenesis|N-cadherin signaling events|Neurotrophic factor-mediated Trk receptor signaling|PDGFR-beta signaling pathway|SHP2 signaling|Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)|Signaling events mediated by Stem cell factor receptor (c-Kit)|Signaling events mediated by VEGFR1 and VEGFR2|Signaling events regulated by Ret tyrosine kinase|TCR signaling in naïve CD4+ T cells|VEGFR1 specific signals"	""	"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon|CTLA4 inhibitory signaling|Constitutive Signaling by Aberrant PI3K in Cancer|Costimulation by the CD28 family|Downstream signal transduction|ERK1 activation|ERK2 activation|FRS-mediated FGFR1 signaling|FRS-mediated FGFR2 signaling|FRS-mediated FGFR3 signaling|FRS2-mediated FGFR4 signaling|GAB1 signalosome|Interferon alpha/beta signaling|Interleukin-3, 5 and GM-CSF signaling|Interleukin-6 signaling|Negative regulation of FGFR1 signaling|Negative regulation of FGFR2 signaling|Negative regulation of FGFR3 signaling|Negative regulation of FGFR4 signaling|Netrin mediated repulsion signals|PD-1 signaling|PECAM1 interactions|PI-3K cascade:FGFR1|PI-3K cascade:FGFR2|PI-3K cascade:FGFR3|PI-3K cascade:FGFR4|PI3K Cascade|PIP3 activates AKT signaling|Platelet sensitization by LDL|Prolactin receptor signaling|Regulation of IFNA signaling|Regulation of IFNG signaling|SHC-mediated cascade:FGFR2|SHC-mediated cascade:FGFR4|Signal regulatory protein (SIRP) family interactions|Signaling by Leptin|Signaling by SCF-KIT|Spry regulation of FGF signaling|Tie2 Signaling"	"AdrenergicRa -> ELK-SRF signaling|AdrenergicRa -> STAT3 signaling|AngiotensinR -> CREB/ELK-SRF/TP53 signaling|EDG2 -> ELK-SRF signaling|ErythropoietinR -> ELK-SRF/FOS signaling|GHR -> ELK-SRF/MYC signaling|IL6R -> CEBP/ELK-SRF signaling|LeptinR -> ELK-SRF signaling|Natural Killer Cell Inhibitory Receptor Signaling|Nociception-related IL6 expression targets|PECAM -> SP1 signaling|Peripheral T-cell Tolerance Overview|SELE -> ELK-SRF signaling"	""	""	"Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity."	""	"TRUE"
"3399-31_2"	"SL007560"	"STAB2"	"Stabilin-2"	"12"	"103587273"	"103766727"	"STAB2"	"55576"	"Q8WWQ8"	""	""	""	""	""	""	"diagnosis"	"Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalisation as well as HA and CS."	""	"TRUE"
"3400-49_2"	"SL007747"	"TBK1"	"Serine/threonine-protein kinase TBK1"	"12"	"64451880"	"64502108"	"TBK1"	"29110"	"Q9UHD2"	"Regulation of toll-like receptor signaling pathway|TNF alpha Signaling Pathway|Toll-like receptor signaling pathway"	""	""	"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon|IRF3 mediated activation of type 1 IFN|IRF3-mediated induction of type I IFN|Negative regulators of RIG-I/MDA5 signaling|Regulation of innate immune responses to cytosolic DNA|STAT6-mediated induction of chemokines|TRAF3-dependent IRF activation pathway|TRAF6 mediated IRF7 activation"	"Antiviral Signaling through Pattern Recognition Receptors|TLR3 -> IRF signaling|TLR3 -> NF-kB signaling|TLR4 -> IRF signaling|TLR4 Signaling in Leukocytes"	""	""	"Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes. Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus. Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy. Phosphorylates and activates AKT1. Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C. Phosphorylates Borna disease virus (BDV) P protein."	""	"TRUE"
"3401-8_2"	"SL005261"	"TCPTP"	"Tyrosine-protein phosphatase non-receptor type 2"	"18"	"12785478"	"12929643"	"PTPN2"	"5771"	"P17706"	""	"IFN-gamma pathway|PDGFR-beta signaling pathway|Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)|Signaling events mediated by TCPTP|Signaling events mediated by VEGFR1 and VEGFR2"	""	"Regulation of IFNG signaling"	""	""	""	"Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3, STAT5A, STAT5B and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Plays also an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the IL6 signaling pathways. Finally, it negatively regulates prolactin-mediated signaling pathway through dephosphorylation of STAT5A and STAT5B. May also bind DNA."	""	"TRUE"
"3403-1_2"	"SL010617"	"TPSB2"	"Tryptase beta-2"	"16"	"1227272"	"1242554"	"TPSB2"	"64499"	"P20231"	""	""	""	""	""	""	""	"Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity."	"147"	"TRUE"
"3404-51_2"	"SL010619"	"TPSG1"	"Tryptase gamma"	"16"	"1221651"	"1225257"	"TPSG1"	"25823"	"Q9NRR2"	""	""	""	""	""	""	""	"Membrane"	""	"TRUE"
"3405-6_2"	"SL010529"	"UFC1"	"Ubiquitin-fold modifier-conjugating enzyme 1"	"1"	"161152776"	"161158856"	"UFC1"	"51506"	"Q9Y3C8"	""	""	""	""	""	""	""	"E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage."	""	"FALSE"
"3412-7_1"	"SL000104"	"Bcl-2"	"Apoptosis regulator Bcl-2"	"18"	"63123346"	"63320128"	"BCL2"	"596"	"P10415"	"Apoptosis|Apoptosis Modulation and Signaling|DNA damage response (only ATM dependent)|Estrogen signaling pathway|FAS pathway and Stress induction of HSP regulation|Focal Adhesion|IL-2 Signaling pathway|IL-3 Signaling Pathway|IL-5 signaling pathway|Integrated Breast Cancer Pathway|Integrated Cancer pathway|Kit receptor signaling pathway|Leukocyte TarBase|Lymphocyte TarBase|Muscle cell TarBase|Senescence and Autophagy|TP53 network"	"ATF-2 transcription factor network|C-MYB transcription factor network|Caspase Cascade in Apoptosis|Ceramide signaling pathway|Direct p53 effectors|EPO signaling pathway|HIV-1 Nef: Negative effector of Fas and TNF-alpha|IL2 signaling events mediated by PI3K|IL2 signaling events mediated by STAT5|IL2-mediated signaling events|RXR and RAR heterodimerization with other nuclear receptor|Role of Calcineurin-dependent NFAT signaling in lymphocytes|Signaling events mediated by Stem cell factor receptor (c-Kit)|Validated targets of C-MYC transcriptional repression"	""	"Activation of BAD and translocation to mitochondria|BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members|The NLRP1 inflammasome"	"Apoptosis|Central T-cell Tolerance|Model of T-cell Maturation|NOD-like Receptors in Pathogen Recognition|Peripheral T-cell Tolerance Overview|T-cell Positive Selection and Neglect-Induced Death"	"oblimersen|rasagiline|(-)-gossypol|gemcitabine/paclitaxel|bortezomib/paclitaxel|paclitaxel/trastuzumab|paclitaxel/pertuzumab/trastuzumab|lapatinib/paclitaxel|doxorubicin/paclitaxel|epirubicin/paclitaxel|paclitaxel/topotecan|paclitaxel"	"diagnosis|efficacy|prognosis"	"Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785)."	""	"TRUE"
"3413-50_2"	"SL003703"	"BFL1"	"Bcl-2-related protein A1"	"15"	"79960889"	"79971446"	"BCL2A1"	"597"	"Q16548"	"Apoptosis Modulation and Signaling"	"BCR signaling pathway|Direct p53 effectors"	""	""	""	""	""	"Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity). Can inhibit apoptosis induced by serum starvation in the mammary epithelial cell line HC11 (By similarity)."	""	"TRUE"
"3414-40_2"	"SL006374"	"BMX"	"Cytoplasmic tyrosine-protein kinase BMX"	"X"	"15464246"	"15556529"	"BMX"	"660"	"P51813"	"angiogenesis overview"	"Angiopoietin receptor Tie2-mediated signaling|Signaling events mediated by focal adhesion kinase"	""	"Apoptotic cleavage of cellular proteins"	""	""	""	"Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells."	""	"TRUE"
"3415-61_2"	"SL004660"	"BSP"	"Bone sialoprotein 2"	"4"	"87799581"	"87812435"	"IBSP"	"3381"	"P21815"	"Focal Adhesion|Osteoblast Signaling"	"Beta3 integrin cell surface interactions"	""	"ECM proteoglycans|Integrin cell surface interactions"	""	""	"efficacy"	"Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment."	""	"TRUE"
"3416-2_2"	"SL010521"	"BTK"	"Tyrosine-protein kinase BTK"	"X"	"101349447"	"101390796"	"BTK"	"695"	"Q06187"	"B Cell Receptor Signaling Pathway|IL-5 signaling pathway|Kit receptor signaling pathway|Regulation of toll-like receptor signaling pathway"	"BCR signaling pathway|Class I PI3K signaling events|EPO signaling pathway|FAS (CD95) signaling pathway|Fc-epsilon receptor I signaling in mast cells"	""	"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers|DAP12 signaling|FCERI mediated Ca+2 mobilization|IRAK4 deficiency (TLR2/4)|MyD88 deficiency (TLR2/4)|MyD88:Mal cascade initiated on plasma membrane|RHO GTPases Activate WASPs and WAVEs|Regulation of actin dynamics for phagocytic cup formation"	"\"Dectin-2 (CLEC6A), Mincle (CLEC4E), and BDCA2 (CLEC4C) Signaling\"|B-cell receptor -> AP-1 signaling|B-cell receptor -> NF-kB signaling|B-cell receptor -> NFATC signaling|CD19 ->  AP-1/ELK-SRF signaling|T-cell receptor -> AP-1 signaling|T-cell receptor -> ATF/CREB signaling|T-cell receptor -> CREBBP signaling|T-cell receptor -> NF-kB signaling|T-cell receptor -> NFATC signaling|T-cell-Dependent B-cell Activation|T-cell-Independent B-cell Activation|V(D)J Recombination Activation"	"ibrutinib|bendamustine/ibrutinib/rituximab"	""	"Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells. Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation. BTK plays also a critical role in transcription regulation. Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes. BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B. Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR. GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression. ARID3A and NFAT are other transcriptional target of BTK. BTK is required for the formation of functional ARID3A DNA-binding complexes. There is however no evidence that BTK itself binds directly to DNA. BTK has a dual role in the regulation of apoptosis."	""	"FALSE"
"3418-12_2"	"SL010490"	"CAMK1D"	"Calcium/calmodulin-dependent protein kinase type 1D"	"10"	"12349482"	"12835545"	"CAMK1D"	"57118"	"Q8IU85"	""	""	""	""	""	""	""	"Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta."	"82"	"TRUE"
"3419-49_2"	"SL010493"	"CAMK2D"	"Calcium/calmodulin-dependent protein kinase type II subunit delta"	"4"	"113451032"	"113761927"	"CAMK2D"	"817"	"Q13557"	"Calcium Regulation in the Cardiac Cell|MicroRNAs in cardiomyocyte hypertrophy|Myometrial Relaxation and Contraction Pathways|Physiological and Pathological Hypertrophy  of the Heart|SRF and miRs in Smooth Muscle Differentiation and Proliferation"	"IFN-gamma pathway|Notch-mediated HES/HEY network"	""	"CREB phosphorylation through the activation of CaMKII|CREB phosphorylation through the activation of Ras|HSF1-dependent transactivation|Interferon gamma signaling|Ras activation uopn Ca2+ infux through NMDA receptor|Trafficking of AMPA receptors|Unblocking of NMDA receptor, glutamate binding and activation"	""	""	""	"Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor."	""	"TRUE"
"3420-21_2"	"SL004869"	"Carbonic anhydrase XIII"	"Carbonic anhydrase 13"	"8"	"85220587"	"85284073"	"CA13"	"377677"	"Q8N1Q1"	""	""	""	"Reversible hydration of carbon dioxide"	""	"methazolamide|hydrochlorothiazide|acetazolamide|trichloromethiazide|chlorothiazide|chlorthalidone|benzthiazide|sulfacetamide|topiramate"	""	"Reversible hydration of carbon dioxide."	"197"	"TRUE"
"3421-54_2"	"SL004635"	"CD30 Ligand"	"Tumor necrosis factor ligand superfamily member 8"	"9"	"114893343"	"114930595"	"TNFSF8"	"944"	"P32971"	""	""	""	""	""	""	""	"Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells."	""	"TRUE"
"3422-4_2"	"SL010494"	"CDK1/cyclin B"	"Cyclin-dependent kinase 1:G2/mitotic-specific cyclin-B1 complex"	"10|5"	"60778331|69167010"	"60794852|69178245"	"CDC2|CCNB1"	"983|891"	"P06493|P14635"	"AMPK signaling|Cell cycle|DNA damage response|G1 to S cell cycle control|miRNA regulation of DNA Damage Response"	"C-MYB transcription factor network|Direct p53 effectors|FOXM1 transcription factor network|FoxO family signaling|PLK1 signaling events|Validated targets of C-MYC transcriptional activation|p73 transcription factor network"	""	"APC/C:Cdc20 mediated degradation of Cyclin B|Activation of NIMA Kinases NEK9, NEK6, NEK7|Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex|Condensation of Prometaphase Chromosomes|Condensation of Prophase Chromosomes|Cyclin A/B1 associated events during G2/M transition|Depolymerisation of the Nuclear Lamina|E2F-enabled inhibition of pre-replication complex formation|G2/M DNA replication checkpoint|Golgi Cisternae Pericentriolar Stack Reorganization|MASTL Facilitates Mitotic Progression|Nuclear Pore Complex (NPC) Disassembly|Phosphorylation of Emi1|Phosphorylation of the APC/C|Polo-like kinase mediated events|Recruitment of NuMA to mitotic centrosomes|Regulation of APC/C activators between G1/S and early anaphase|Regulation of PLK1 Activity at G2/M Transition|Resolution of Sister Chromatid Cohesion"	"Cell Cycle"	""	""	"Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, LMNA, LMNB, LMNC, LBR, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, UL40/R2, RAB4A, RAP1GAP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1, SIRT2 and RUNX2. CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs. Essential for early stages of embryonic development. During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation. Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis. Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair. Reactivated after successful DNA repair through WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression. In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons. The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis. NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. In addition, CC2D1A phosphorylation regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis. The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis. In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis. This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration. CDK1-cyclin-B complex phosphorylates NCKAP5L and mediates its dissociation from centrosomes during mitosis (PubMed:26549230).|Essential for the control of the cell cycle at the G2/M (mitosis) transition."	""	"TRUE"
"3423-59_2"	"SL005250"	"Chymase"	"Chymase"	"14"	"24505353"	"24508265"	"CMA1"	"1215"	"P23946"	"ACE Inhibitor Pathway"	""	""	"Activation of Matrix Metalloproteinases|Metabolism of Angiotensinogen to Angiotensins|Signaling by SCF-KIT"	"Extracellular Matrix Turnover"	""	""	"Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion."	""	"TRUE"
"3427-63_2"	"SL007324"	"CSK21"	"Casein kinase II subunit alpha"	"20"	"473591"	"543821"	"CSNK2A1"	"1457"	"P68400"	"TNF alpha Signaling Pathway"	"Alpha-synuclein signaling|Atypical NF-kappaB pathway|BCR signaling pathway|DNA-PK pathway in nonhomologous end joining|E-cadherin signaling in the nascent adherens junction|Lissencephaly gene (LIS1) in neuronal migration and development|PDGFR-alpha signaling pathway|Presenilin action in Notch and Wnt signaling|Role of Calcineurin-dependent NFAT signaling in lymphocytes|Signaling mediated by p38-alpha and p38-beta"	""	"Condensation of Prometaphase Chromosomes|Signal transduction by L1|WNT mediated activation of DVL"	""	""	""	"Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation. Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:19188443, PubMed:20625391, PubMed:22406621). Phosphorylates CCAR2 at 'Thr-454' in gastric carcinoma tissue (PubMed:24962073)."	""	"TRUE"
"3431-54_2"	"SL004137"	"EphA1"	"Ephrin type-A receptor 1"	"7"	"143390289"	"143408892"	"EPHA1"	"2041"	"P21709"	""	"EPHA forward signaling"	""	"EPH-Ephrin signaling|EPH-ephrin mediated repulsion of cells|EPHA-mediated growth cone collapse|POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation"	""	""	""	"Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis."	"42"	"TRUE"
"3432-21_2"	"SL010498"	"EPHA3"	"Ephrin type-A receptor 3"	"3"	"89107524"	"89482134"	"EPHA3"	"2042"	"P29320"	""	"EPHA forward signaling|EphrinA-EPHA pathway"	""	"EPH-Ephrin signaling|EPH-ephrin mediated repulsion of cells|EPHA-mediated growth cone collapse"	"EphrinR -> STAT signaling"	""	""	"Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development."	""	"TRUE"
"3434-34_1"	"SL010349"	"FN1.3"	"Fibronectin Fragment 3"	"2"	"215360440"	"215436172"	"FN1"	"2335"	"P02751"	"Focal Adhesion|Inflammatory Response Pathway|Regulation of Actin Cytoskeleton|Senescence and Autophagy"	"Alpha4 beta1 integrin signaling events|Alpha9 beta1 integrin signaling events|Angiopoietin receptor Tie2-mediated signaling|Beta1 integrin cell surface interactions|Beta3 integrin cell surface interactions|Beta5 beta6 beta7 and beta8 integrin cell surface interactions|Integrins in angiogenesis|Syndecan-2-mediated signaling events|Syndecan-4-mediated signaling events|Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling|VEGFR3 signaling in lymphatic endothelium"	""	"Cell surface interactions at the vascular wall|Degradation of the extracellular matrix|ECM proteoglycans|Extracellular matrix organization|Fibronectin matrix formation|GRB2:SOS provides linkage to MAPK signaling for Integrins|Integrin alphaIIb beta3 signaling|Integrin cell surface interactions|Molecules associated with elastic fibres|Non-integrin membrane-ECM interactions|Platelet degranulation|Syndecan interactions|p130Cas linkage to MAPK signaling for integrins"	"Extracellular Matrix Turnover|FibronectinR -> AP-1/ELK-SRF/SREBF signaling|FibronectinR -> CTNNB signaling|FibronectinR -> ICAP-1A/MYC signaling|FibronectinR -> NF-kB signaling|Focal Junction Assembly|Natural Killer Cell Activation through Integrins and non-ITAM-Containing Receptors"	"ocriplasmin"	"diagnosis|efficacy|prognosis|unspecified application"	"Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts."	"77|380"	"TRUE"
"3435-53_2"	"SL010348"	"FN1.4"	"Fibronectin Fragment 4"	"2"	"215360440"	"215436172"	"FN1"	"2335"	"P02751"	"Focal Adhesion|Inflammatory Response Pathway|Regulation of Actin Cytoskeleton|Senescence and Autophagy"	"Alpha4 beta1 integrin signaling events|Alpha9 beta1 integrin signaling events|Angiopoietin receptor Tie2-mediated signaling|Beta1 integrin cell surface interactions|Beta3 integrin cell surface interactions|Beta5 beta6 beta7 and beta8 integrin cell surface interactions|Integrins in angiogenesis|Syndecan-2-mediated signaling events|Syndecan-4-mediated signaling events|Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling|VEGFR3 signaling in lymphatic endothelium"	""	"Cell surface interactions at the vascular wall|Degradation of the extracellular matrix|ECM proteoglycans|Extracellular matrix organization|Fibronectin matrix formation|GRB2:SOS provides linkage to MAPK signaling for Integrins|Integrin alphaIIb beta3 signaling|Integrin cell surface interactions|Molecules associated with elastic fibres|Non-integrin membrane-ECM interactions|Platelet degranulation|Syndecan interactions|p130Cas linkage to MAPK signaling for integrins"	"Extracellular Matrix Turnover|FibronectinR -> AP-1/ELK-SRF/SREBF signaling|FibronectinR -> CTNNB signaling|FibronectinR -> ICAP-1A/MYC signaling|FibronectinR -> NF-kB signaling|Focal Junction Assembly|Natural Killer Cell Activation through Integrins and non-ITAM-Containing Receptors"	"ocriplasmin"	"diagnosis|efficacy|prognosis|unspecified application"	"Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts."	"77"	"TRUE"
"3437-80_3"	"SL004636"	"Flt-3"	"Receptor-type tyrosine-protein kinase FLT3"	"13"	"28003274"	"28100592"	"FLT3"	"2322"	"P36888"	""	""	""	""	"V(D)J Recombination Activation"	"sunitinib|dovitinib|tandutinib|cabozantinib|nintedanib|ponatinib|bortezomib/sorafenib|dexamethasone/lenalidomide/sorafenib|bevacizumab/sorafenib|cabozantinib/erlotinib|sorafenib|lestaurtinib|midostaurin"	"efficacy|prognosis"	"Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways."	""	"TRUE"
"3438-10_2"	"SL009324"	"FSTL3"	"Follistatin-related protein 3"	"19"	"676365"	"683390"	"FSTL3"	"10272"	"O95633"	""	""	""	"Antagonism of Activin by Follistatin"	""	""	""	"Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10."	""	"TRUE"
"3440-7_2"	"SL004298"	"granzyme A"	"Granzyme A"	"5"	"55102648"	"55110252"	"GZMA"	"3001"	"P12544"	""	"IL12-mediated signaling events"	""	""	"CD8+ T-cell Activation|Cell Death Mediated by Cytotoxic Cells|Natural Killer Cell Activation"	""	""	"Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA."	"387"	"TRUE"
"3441-64_2"	"SL017188"	"GSK-3 alpha/beta"	"Glycogen synthase kinase-3 alpha/beta"	"19|3"	"42230186|119821323"	"42242625|120094417"	"GSK3A|GSK3B"	"2931|2932"	"P49840|P49841"	"B Cell Receptor Signaling Pathway|Glycogen Metabolism|IL-5 signaling pathway|Insulin Signaling|Integrated Breast Cancer Pathway"	"Canonical Wnt signaling pathway|Class I PI3K signaling events mediated by Akt|Degradation of beta catenin|FOXM1 transcription factor network"	""	"AKT phosphorylates targets in the cytosol|Constitutive Signaling by AKT1 E17K in Cancer|XBP1(S) activates chaperone genes"	""	""	""	"Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation.|Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin. Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules. MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin. Is necessary for the establishment of neuronal polarity and axon outgrowth. Phosphorylates MARK2, leading to inhibit its activity. Phosphorylates SIK1 at 'Thr-182', leading to sustain its activity. Phosphorylates ZC3HAV1 which enhances its antiviral activity. Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitination and proteasomal degradation. Phosphorylates SFPQ at 'Thr-687' upon T-cell activation. Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including ARNTL/BMAL1, CLOCK and PER2. Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation. Phosphorylates ARNTL/BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation. Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positively regulates its activity. Phosphorylates MYCN in neuroblastoma cells which may promote its degradation (PubMed:24391509)."	""	"FALSE"
"3443-61_2"	"SL010523"	"HIPK3"	"Homeodomain-interacting protein kinase 3"	"11"	"33256672"	"33357023"	"HIPK3"	"10114"	"Q9H422"	"Adipocyte TarBase|Lymphocyte TarBase|Muscle cell TarBase"	""	""	""	""	""	""	"Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE)."	""	"TRUE"
"3445-53_2"	"SL004151"	"IL-15 Ra"	"Interleukin-15 receptor subunit alpha"	"10"	"5937569"	"5978187"	"IL15RA"	"3601"	"Q13261"	"TCR Signaling Pathway"	""	""	""	"IL15R -> NF-kB/NFATC signaling|IL15R -> STAT signaling"	""	"prognosis"	"High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves SYK."	"309"	"TRUE"
"3446-7_2"	"SL004152"	"IL-18 Ra"	"Interleukin-18 receptor 1"	"2"	"102311529"	"102398775"	"IL18R1"	"8809"	"Q13478"	""	"IL12 signaling mediated by STAT4|IL12-mediated signaling events|IL23-mediated signaling events"	""	""	"Th1 Cell Differentiation"	""	""	"Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B."	"19|247|341|386"	"TRUE"
"3447-64_2"	"SL000039"	"IL-8"	"Interleukin-8"	"4"	"73740506"	"73743716"	"CXCL8"	"3576"	"P10145"	"EBV LMP1 signaling|IL-3 Signaling Pathway|Regulation of toll-like receptor signaling pathway|SIDS Susceptibility Pathways|Senescence and Autophagy|Toll-like receptor signaling pathway"	"AP-1 transcription factor network|ATF-2 transcription factor network|Calcineurin-regulated NFAT-dependent transcription in lymphocytes|Glucocorticoid receptor regulatory network|IL8- and CXCR1-mediated signaling events|IL8- and CXCR2-mediated signaling events|IL8-mediated signaling events|LPA receptor mediated events|Regulation of nuclear beta catenin signaling and target gene transcription|Syndecan-2-mediated signaling events|Syndecan-3-mediated signaling events|Validated transcriptional targets of AP1 family members Fra1 and Fra2"	""	"ATF4 activates genes|Chemokine receptors bind chemokines|G alpha (i) signalling events|Peptide ligand-binding receptors|Senescence-Associated Secretory Phenotype (SASP)"	""	""	"diagnosis|efficacy|prognosis|unspecified application"	"IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively."	""	"TRUE"
"3448-13_2"	"SL004125"	"IR"	"Insulin receptor"	"19"	"7112255"	"7294034"	"INSR"	"3643"	"P06213"	"AMPK signaling|DNA damage response (only ATM dependent)|Folate Metabolism|Insulin Signaling|Selenium Pathway|Type II diabetes mellitus|Vitamin B12 Metabolism"	"Insulin Pathway|Insulin-mediated glucose transport|Signaling events mediated by PTP1B|Signaling events mediated by TCPTP"	""	"IRS activation|Insulin receptor recycling|SHC activation|Signal attenuation|Signaling by Insulin receptor"	"InsulinR -> CTNNB/FOXA/FOXO signaling|InsulinR -> ELK-SRF/SREBF signaling|InsulinR -> STAT signaling"	"insulin detemir|INS|canakinumab/INS|insulin aspart/insulin detemir|ceritinib|insulin glargine/insulin lispro|insulin aspart|insulin glulisine|insulin lispro|insulin glargine|protamine zinc insulin"	"prognosis"	"Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin."	"28|354"	"TRUE"
"3449-58_2"	"SL004876"	"Kallistatin"	"Kallistatin"	"14"	"94561091"	"94569913"	"SERPINA4"	"5267"	"P29622"	""	""	""	""	""	""	""	"Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein."	"81|451"	"TRUE"
"3450-4_2"	"SL001797"	"Kallikrein 6"	"Kallikrein-6"	"19"	"50958631"	"50969673"	"KLK6"	"5653"	"Q92876"	""	"Alpha-synuclein signaling"	""	""	""	""	"diagnosis|prognosis"	"Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis."	""	"TRUE"
"3452-17_2"	"SL006916"	"LCK"	"Tyrosine-protein kinase Lck"	"1"	"32251239"	"32286165"	"LCK"	"3932"	"P06239"	"IL-2 Signaling pathway|Inflammatory Response Pathway|Notch Signaling Pathway"	"Alpha-synuclein signaling|Atypical NF-kappaB pathway|CXCR4-mediated signaling events|Class I PI3K signaling events|EPHA forward signaling|Ephrin B reverse signaling|Glypican 1 network|IL12-mediated signaling events|IL2 signaling events mediated by PI3K|IL2 signaling events mediated by STAT5|IL2-mediated signaling events|PDGFR-beta signaling pathway|Regulation of p38-alpha and p38-beta|SHP2 signaling|Signaling events mediated by PTP1B|TCR signaling in naïve CD4+ T cells|TCR signaling in naïve CD8+ T cells|Thromboxane A2 receptor signaling|amb2 Integrin signaling"	""	"CD28 co-stimulation|CD28 dependent PI3K/Akt signaling|CD28 dependent Vav1 pathway|CTLA4 inhibitory signaling|Constitutive Signaling by Aberrant PI3K in Cancer|DAP12 signaling|Downstream TCR signaling|GPVI-mediated activation cascade|Generation of second messenger molecules|Interleukin-2 signaling|Nef Mediated CD4 Down-regulation|Nef and signal transduction|PD-1 signaling|PECAM1 interactions|PIP3 activates AKT signaling|Phosphorylation of CD3 and TCR zeta chains|Regulation of KIT signaling|Signaling by SCF-KIT|Translocation of ZAP-70 to Immunological synapse"	"AngiopoietinR -> STAT signaling|CD2 -> NFATC1 signaling|CD2 -> STAT signaling|CD38 ->  NF-kB signaling|CD8+ T-cell Activation|Central T-cell Tolerance|DC-SIGN (CD209) Signaling|FcIgER -> ELK-SRF signaling|FcIgER -> NFATC1 signaling|IL2R -> ELK-SRF/MYC signaling|Model of T-cell Maturation|Natural Killer Cell Activation through C-type Lectin-like Receptors|Natural Killer Cell Activation through ITAM-Containing Receptors|Natural Killer Cell Inhibitory Receptor Signaling|Notch -> NF-kB signaling|PECAM -> SP1 signaling|PECAM -> STAT signaling|PTPRC -> BCL6 signaling|Peripheral T-cell Tolerance Overview|Regulatory T-cell Differentiation|T-cell Receptor Signaling|T-cell receptor -> AP-1 signaling|T-cell receptor -> ATF/CREB signaling|T-cell receptor -> CREBBP signaling|T-cell receptor -> NF-kB signaling|T-cell receptor -> NFATC signaling|T-cell receptor -> STAT signaling|Th1 Cell Differentiation|Th17 Cell Differentiation|Th2 Cell Differentiation"	"dasatinib|pazopanib|nintedanib"	"diagnosis"	"Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP."	""	"TRUE"
"3453-87_2"	"SL006917"	"LYN"	"Tyrosine-protein kinase Lyn"	"8"	"55879813"	"56014168"	"LYN"	"4067"	"P07948"	"B Cell Receptor Signaling Pathway|IL-3 Signaling Pathway|IL-5 signaling pathway|Kit receptor signaling pathway|RANKL/RANK Signaling Pathway"	"Alpha-synuclein signaling|BCR signaling pathway|CXCR4-mediated signaling events|Class I PI3K signaling events|EPHA forward signaling|EPO signaling pathway|Ephrin B reverse signaling|Fc-epsilon receptor I signaling in mast cells|GMCSF-mediated signaling events|Glypican 1 network|IL5-mediated signaling events|IL8- and CXCR1-mediated signaling events|IL8- and CXCR2-mediated signaling events|LPA receptor mediated events|PDGFR-beta signaling pathway|Regulation of p38-alpha and p38-beta|Signaling events mediated by PTP1B|Signaling events mediated by Stem cell factor receptor (c-Kit)|Thromboxane A2 receptor signaling|amb2 Integrin signaling"	""	"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers|CD209 (DC-SIGN) signaling|CD28 co-stimulation|CTLA4 inhibitory signaling|Cell surface interactions at the vascular wall|Dectin-2 family|EPH-Ephrin signaling|EPH-ephrin mediated repulsion of cells|EPHA-mediated growth cone collapse|EPHB-mediated forward signaling|FCERI mediated Ca+2 mobilization|FCERI mediated MAPK activation|FCERI mediated NF-kB activation|FCGR activation|Fc epsilon receptor (FCERI) signaling|GPVI-mediated activation cascade|Growth hormone receptor signaling|PECAM1 interactions|Platelet Adhesion to exposed collagen|Regulation of KIT signaling|Regulation of signaling by CBL|Role of LAT2/NTAL/LAB on calcium mobilization|Signaling by SCF-KIT"	"B-cell receptor -> AP-1 signaling|B-cell receptor -> NF-kB signaling|B-cell receptor -> NFATC signaling|CD19 ->  AP-1/ELK-SRF signaling|CD19 -> NF-kB signaling|IL7R -> FOXO/NF-kB signaling|Natural Killer Cell Inhibitory Receptor Signaling|T-cell receptor -> AP-1 signaling|T-cell receptor -> ATF/CREB signaling|T-cell receptor -> CREBBP signaling|T-cell receptor -> NF-kB signaling|T-cell receptor -> NFATC signaling|T-cell-Dependent B-cell Activation|T-cell-Independent B-cell Activation|V(D)J Recombination Activation"	"nintedanib|bosutinib"	""	"Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, PTK2B/PYK2, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation."	""	"TRUE"
"3457-57_1"	"SL005084"	"Periostin"	"Periostin"	"13"	"37562583"	"37598844"	"POSTN"	"10631"	"Q15063"	""	""	""	""	""	""	"unspecified application"	"Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity). Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization."	""	"TRUE"
"3459-49_2"	"SL004155"	"PDGF Rb"	"Platelet-derived growth factor receptor beta"	"5"	"150113837"	"150155872"	"PDGFRB"	"5159"	"P09619"	"Focal Adhesion|MAPK signaling pathway|Osteoblast Signaling|Regulation of Actin Cytoskeleton"	"Beta3 integrin cell surface interactions|Nectin adhesion pathway|PDGF receptor signaling network|PDGFR-beta signaling pathway|S1P1 pathway|S1P3 pathway|SHP2 signaling|Signaling events mediated by PTP1B|Signaling events mediated by TCPTP|Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling|Validated targets of C-MYC transcriptional repression"	""	"Constitutive Signaling by Aberrant PI3K in Cancer|Downstream signal transduction|PIP3 activates AKT signaling|Signaling by PDGF"	"PDGFR -> AP-1/MYC signaling|PDGFR -> FOXO3A signaling|PDGFR -> STAT signaling|UrokinaseR -> ELK-SRF signaling"	"nilotinib|dasatinib|sunitinib|pazopanib|axitinib|tivozanib|tandutinib|nintedanib|regorafenib|bortezomib/sorafenib|lapatinib/pazopanib|dexamethasone/lenalidomide/sorafenib|bevacizumab/sorafenib|imatinib/sirolimus|imatinib|sorafenib|becaplermin"	"prognosis|response to therapy|unspecified application"	"Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor."	"15|154|329|339"	"TRUE"
"3461-58_1"	"SL009089"	"PGCB"	"Brevican core protein"	"1"	"156641390"	"156659532"	"BCAN"	"63827"	"Q96GW7"	""	""	""	"A tetrasaccharide linker sequence is required for GAG synthesis|CS/DS degradation|Chondroitin sulfate biosynthesis|Defective B3GAT3 causes JDSSDHD|Defective B4GALT7 causes EDS, progeroid type|Defective CHST14 causes EDS, musculocontractural type|Defective CHST3 causes SEDCJD|Defective CHSY1 causes TPBS|Degradation of the extracellular matrix|Dermatan sulfate biosynthesis|ECM proteoglycans"	""	""	""	"May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans."	""	"TRUE"
"3466-8_2"	"SL010513"	"PRKACA"	"cAMP-dependent protein kinase catalytic subunit alpha"	"19"	"14091688"	"14118084"	"PRKACA"	"5566"	"P17612"	"Calcium Regulation in the Cardiac Cell|Endochondral Ossification|Estrogen signaling pathway|FSH signaling pathway|G Protein Signaling Pathways|Hypothetical Network for Drug Addiction|IL-3 Signaling Pathway|MAPK signaling pathway|Myometrial Relaxation and Contraction Pathways|Nicotine Activity on Dopaminergic Neurons|miRs in Muscle Cell Differentiation"	"Alpha4 beta1 integrin signaling events|Aurora A signaling|Calcium signaling in the CD4+ TCR pathway|Class I PI3K signaling events mediated by Akt|ErbB2/ErbB3 signaling events|GMCSF-mediated signaling events|Glucocorticoid receptor regulatory network|Hedgehog signaling events mediated by Gli proteins|IL3-mediated signaling events|LKB1 signaling events|LPA4-mediated signaling events|Retinoic acid receptors-mediated signaling|Role of Calcineurin-dependent NFAT signaling in lymphocytes|SHP2 signaling|Signaling events mediated by HDAC Class I|Signaling events mediated by VEGFR1 and VEGFR2|Signaling events regulated by Ret tyrosine kinase|Syndecan-1-mediated signaling events|Syndecan-2-mediated signaling events|Thromboxane A2 receptor signaling|VEGFR1 specific signals"	""	"Anchoring of the basal body to the plasma membrane|CD209 (DC-SIGN) signaling|CREB phosphorylation through the activation of Adenylate Cyclase|DARPP-32 events|Degradation of GLI1 by the proteasome|Degradation of GLI2 by the proteasome|Factors involved in megakaryocyte development and platelet production|GLI3 is processed to GLI3R by the proteasome|Glucagon-like Peptide-1 (GLP1) regulates insulin secretion|Gluconeogenesis|Hedgehog 'off' state|Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis|Interleukin-3, 5 and GM-CSF signaling|Loss of Nlp from mitotic centrosomes|Loss of proteins required for interphase microtubule organization from the centrosome|PKA activation|PKA activation in glucagon signalling|PKA-mediated phosphorylation of CREB|PKA-mediated phosphorylation of key metabolic factors|Rap1 signalling|Recruitment of mitotic centrosome proteins and complexes|Regulation of PLK1 Activity at G2/M Transition|Regulation of insulin secretion|VEGFA-VEGFR2 Pathway|Vasopressin regulates renal water homeostasis via Aquaporins"	""	""	""	"Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP. Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated. RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+). PSMC5/RPT6 activation by phosphorylation stimulates proteasome. Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation. NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding. Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis. Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation. May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT). Phosphorylates APOBEC3G and AICDA. Isoform 2 phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation."	""	"TRUE"
"3469-74_1"	"SL010515"	"RPS6KA3"	"Ribosomal protein S6 kinase alpha-3"	"X"	"20149911"	"20267100"	"RPS6KA3"	"6197"	"P51812"	"Cytoplasmic Ribosomal Proteins|EGF/EGFR Signaling Pathway|Insulin Signaling|Kit receptor signaling pathway|MAPK signaling pathway"	"Coregulation of Androgen receptor activity|ErbB1 downstream signaling|PDGFR-beta signaling pathway"	""	"CREB phosphorylation|CREB phosphorylation through the activation of Ras|ERK/MAPK targets|Gastrin-CREB signalling pathway via PKC and MAPK|RSK activation|Recycling pathway of L1|Senescence-Associated Secretory Phenotype (SASP)"	"Histone Phosphorylation"	""	""	"Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression. In LPS-stimulated dendritic cells, is involved in TLR4-induced macropinocytosis, and in myeloma cells, acts as effector of FGFR3-mediated transformation signaling, after direct phosphorylation at Tyr-529 by FGFR3. Phosphorylates DAPK1."	""	"TRUE"
"3470-1_2"	"SL001945"	"sE-Selectin"	"E-Selectin"	"1"	"169722641"	"169764705"	"SELE"	"6401"	"P16581"	""	"ATF-2 transcription factor network|Glucocorticoid receptor regulatory network|Thromboxane A2 receptor signaling"	""	"Cell surface interactions at the vascular wall"	"Leukocyte Adhesion to Endothelial Cell|SELE -> ELK-SRF signaling"	""	"diagnosis|disease progression|efficacy|unspecified application"	"Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis."	"28|354"	"TRUE"
"3471-49_1"	"SL010517"	"STK16"	"Serine/threonine-protein kinase 16"	"2"	"219245455"	"219250337"	"STK16"	"8576"	"O75716"	""	""	""	""	""	""	""	"Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins."	""	"TRUE"
"3472-40_2"	"SL000582"	"Survivin"	"Baculoviral IAP repeat-containing protein 5"	"17"	"78214186"	"78225636"	"BIRC5"	"332"	"O15392"	"Apoptosis|Apoptosis Modulation and Signaling|IL-4 signaling pathway"	"Aurora A signaling|Aurora B signaling|FOXM1 transcription factor network|Validated targets of C-MYC transcriptional activation"	""	"Mitotic Prometaphase|RHO GTPases Activate Formins|Resolution of Sister Chromatid Cohesion|Separation of Sister Chromatids"	"Apoptosis|Cell Cycle|Peripheral T-cell Tolerance Overview"	""	"diagnosis|disease progression|efficacy|prognosis|response to therapy"	"Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform."	""	"TRUE"
"3473-78_2"	"SL005224"	"Thrombopoietin Receptor"	"Thrombopoietin Receptor"	"1"	"43337807"	"43352772"	"MPL"	"4352"	"P40238"	""	""	""	"Platelet Aggregation (Plug Formation)"	"ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling|ThrombopoietinR -> SP1 signaling|ThrombopoietinR -> SPI1 signaling|ThrombopoietinR -> STAT signaling"	"eltrombopag|romiplostim"	""	"Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses."	""	"TRUE"
"3474-19_2"	"SL002705"	"Thrombospondin-1"	"Thrombospondin-1"	"15"	"39581079"	"39599466"	"THBS1"	"7057"	"P07996"	"Focal Adhesion|Inflammatory Response Pathway|Leukocyte TarBase|Muscle cell TarBase|Senescence and Autophagy|Squamous cell  TarBase|TGF Beta Signaling Pathway"	"Alpha4 beta1 integrin signaling events|Beta1 integrin cell surface interactions|Beta3 integrin cell surface interactions|Syndecan-4-mediated signaling events"	""	"Integrin cell surface interactions|O-glycosylation of TSR domain-containing proteins|Platelet degranulation|Signaling by PDGF|Syndecan interactions"	""	""	"diagnosis|efficacy"	"Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity)."	""	"TRUE"
"3477-63_2"	"SL005225"	"TrkA"	"High affinity nerve growth factor receptor"	"1"	"156815640"	"156881850"	"NTRK1"	"4914"	"P04629"	"MAPK signaling pathway"	"Neurotrophic factor-mediated Trk receptor signaling|SHP2 signaling|Trk receptor signaling mediated by PI3K and PLC-gamma|p73 transcription factor network|p75(NTR)-mediated signaling"	""	"ARMS-mediated activation|Frs2-mediated activation|NGF-independant TRKA activation|PI3K/AKT activation|PLC-gamma1 signalling|Retrograde neurotrophin signalling|Signalling to RAS|Signalling to STAT3|Signalling to p38 via RIT and RIN|TRKA activation by NGF"	"GFs/TNF -> ion channels|NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling|NTRK -> FOXO/MYCN signaling|NTRK1/2/3 -> acetylcholine production|Regulation of calcium flux"	"regorafenib"	""	"Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors."	""	"TRUE"
"3479-71_2"	"SL006480"	"TRY3"	"Trypsin-3"	"9"	"33750466"	"33799231"	"PRSS3"	"5646"	"P35030"	""	""	""	"Alpha-defensins|Cobalamin (Cbl, vitamin B12) transport and metabolism"	""	""	""	"Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5."	""	"TRUE"
"3480-7_1"	"SL008122"	"DUS3"	"Dual specificity protein phosphatase 3"	"17"	"43766121"	"43778988"	"DUSP3"	"1845"	"P51452"	""	""	""	"ERKs are inactivated"	""	""	""	"Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2."	""	"TRUE"
"3481-87_1"	"SL011073"	"XPNPEP1"	"Xaa-Pro aminopeptidase 1"	"10"	"109864766"	"109923553"	"XPNPEP1"	"7511"	"Q9NQW7"	""	""	""	""	""	""	""	"Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro."	""	"TRUE"
"3484-60_2"	"SL000271"	"Angiotensinogen"	"Angiotensinogen"	"1"	"230702523"	"230714297"	"AGT"	"183"	"P01019"	"ACE Inhibitor Pathway|Adipogenesis|IL-6 signaling pathway|MicroRNAs in cardiomyocyte hypertrophy|Monoamine Transport|Physiological and Pathological Hypertrophy  of the Heart"	"AP-1 transcription factor network|Signaling events mediated by PRL"	""	"G alpha (i) signalling events|G alpha (q) signalling events|Metabolism of Angiotensinogen to Angiotensins|PPARA activates gene expression|Peptide ligand-binding receptors"	"AngiotensinR -> CREB/ELK-SRF/TP53 signaling|AngiotensinR -> STAT signaling"	""	"efficacy"	"Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis."	"420"	"TRUE"
"3485-28_2"	"SL000283"	"b2-Microglobulin"	"Beta-2-microglobulin"	"15"	"44711477"	"44718877"	"B2M"	"567"	"P61769"	""	"Downstream signaling in naïve CD8+ T cells|IL12-mediated signaling events|TCR signaling in naïve CD8+ T cells"	""	"Amyloids|Antigen Presentation: Folding, assembly and peptide loading of class I MHC|DAP12 interactions|DAP12 signaling|ER-Phagosome pathway|Endosomal/Vacuolar pathway|Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell|Interferon gamma signaling|Nef mediated downregulation of MHC class I complex cell surface expression"	"MHC1-Mediated Antigen Presentation|Presentation of Endogenous Peptide Antigen"	""	"disease progression|efficacy|safety|unspecified application"	"Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system."	""	"TRUE"
"3486-58_2"	"SL000299"	"b-ECGF"	"Fibroblast growth factor 1"	"5"	"142592178"	"142698070"	"FGF1"	"2246"	"P05230"	"Regulation of Actin Cytoskeleton|angiogenesis overview"	"FGF signaling pathway"	""	"Activated point mutants of FGFR2|Constitutive Signaling by Aberrant PI3K in Cancer|FGFR1b ligand binding and activation|FGFR1c ligand binding and activation|FGFR2b ligand binding and activation|FGFR2c ligand binding and activation|FGFR3 mutant receptor activation|FGFR3b ligand binding and activation|FGFR3c ligand binding and activation|FGFR4 ligand binding and activation|FRS-mediated FGFR1 signaling|FRS-mediated FGFR2 signaling|FRS-mediated FGFR3 signaling|FRS2-mediated FGFR4 signaling|Negative regulation of FGFR1 signaling|Negative regulation of FGFR2 signaling|Negative regulation of FGFR3 signaling|Negative regulation of FGFR4 signaling|PI-3K cascade:FGFR1|PI-3K cascade:FGFR2|PI-3K cascade:FGFR3|PI-3K cascade:FGFR4|PI3K Cascade|PIP3 activates AKT signaling|Phospholipase C-mediated cascade, FGFR2|Phospholipase C-mediated cascade, FGFR3|Phospholipase C-mediated cascade, FGFR4|Phospholipase C-mediated cascade: FGFR1|SHC-mediated cascade:FGFR1|SHC-mediated cascade:FGFR2|SHC-mediated cascade:FGFR3|SHC-mediated cascade:FGFR4|Signaling by FGFR1 mutants|Signaling by FGFR2 mutants|Signaling by FGFR3 mutants|Signaling by FGFR4 mutants|Signaling by activated point mutants of FGFR1|Signaling by activated point mutants of FGFR3"	"FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling|FGFR -> RUNX2 signaling|FGFR1 -> STAT signaling|FGFR3 -> STAT signaling"	"pentosan polysulfate"	"prognosis"	"Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro."	""	"TRUE"
"3487-32_2"	"SL003167"	"BLC"	"C-X-C motif chemokine 13"	"4"	"77511753"	"77611834"	"CXCL13"	"10563"	"O43927"	""	"CXCR3-mediated signaling events"	""	"Chemokine receptors bind chemokines|G alpha (i) signalling events"	""	""	"efficacy|unspecified application"	"Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5."	""	"TRUE"
"3488-64_2"	"SL000342"	"Catalase"	"Catalase"	"11"	"34438925"	"34472062"	"CAT"	"847"	"P04040"	"DNA damage response (only ATM dependent)|Folate Metabolism|Oxidative Stress|Selenium Pathway|Tryptophan metabolism"	"FoxO family signaling"	""	"Detoxification of Reactive Oxygen Species|Purine catabolism"	"Peroxisome Protein Import and Peroxisome Division"	"fomepizole"	"diagnosis"	"Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells."	"71|161"	"TRUE"
"3489-9_2"	"SL004331"	"CNTF"	"Ciliary Neurotrophic Factor"	"11"	"58622673"	"58625733"	"CNTF"	"1270"	"P26441"	""	""	""	""	"CNTFR -> STAT3 signaling"	""	""	"CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy."	""	"TRUE"
"3492-58_1"	"SL000408"	"Epo"	"Erythropoietin"	"7"	"100720800"	"100723700"	"EPO"	"2056"	"P01588"	"NA"	"NA"	"NA"	"NA"	"NA"	""	"disease progression"	"Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass."	""	"TRUE"
"3494-71_3"	"SL004335"	"FGF-17"	"Fibroblast growth factor 17"	"8"	"22042398"	"22048809"	"FGF17"	"8822"	"O60258"	"Regulation of Actin Cytoskeleton"	"FGF signaling pathway"	""	"Activated point mutants of FGFR2|Constitutive Signaling by Aberrant PI3K in Cancer|FGFR1c ligand binding and activation|FGFR2c ligand binding and activation|FGFR3 mutant receptor activation|FGFR3b ligand binding and activation|FGFR3c ligand binding and activation|FGFR4 ligand binding and activation|FRS-mediated FGFR1 signaling|FRS-mediated FGFR2 signaling|FRS-mediated FGFR3 signaling|FRS2-mediated FGFR4 signaling|Negative regulation of FGFR1 signaling|Negative regulation of FGFR2 signaling|Negative regulation of FGFR3 signaling|Negative regulation of FGFR4 signaling|PI-3K cascade:FGFR1|PI-3K cascade:FGFR2|PI-3K cascade:FGFR3|PI-3K cascade:FGFR4|PI3K Cascade|PIP3 activates AKT signaling|Phospholipase C-mediated cascade, FGFR2|Phospholipase C-mediated cascade, FGFR3|Phospholipase C-mediated cascade, FGFR4|Phospholipase C-mediated cascade: FGFR1|SHC-mediated cascade:FGFR1|SHC-mediated cascade:FGFR2|SHC-mediated cascade:FGFR3|SHC-mediated cascade:FGFR4|Signaling by FGFR1 mutants|Signaling by FGFR2 mutants|Signaling by FGFR3 mutants|Signaling by FGFR4 mutants|Signaling by activated point mutants of FGFR1|Signaling by activated point mutants of FGFR3"	""	""	""	"Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development."	""	"TRUE"
"3495-15_2"	"SL003172"	"GCP-2"	"C-X-C motif chemokine 6"	"4"	"73836497"	"73849064"	"CXCL6"	"6372"	"P80162"	""	""	""	"Chemokine receptors bind chemokines|G alpha (i) signalling events"	"IL8R -> CREB/EGR signaling"	""	"unspecified application"	"Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7)."	"25"	"TRUE"
"3497-13_2"	"SL002075"	"IFN-aA"	"Interferon alpha-2"	"9"	"21384254"	"21385388"	"IFNA2"	"3440"	"P01563"	"Regulation of toll-like receptor signaling pathway|Toll-like receptor signaling pathway|Type II interferon signaling (IFNG)"	"Downstream signaling in naïve CD8+ T cells"	""	"Factors involved in megakaryocyte development and platelet production|Interferon alpha/beta signaling|Regulation of IFNA signaling|TRAF6 mediated IRF7 activation"	"IFNAR -> STAT signaling"	""	""	"Produced by macrophages, IFN-alpha have antiviral activities."	""	"TRUE"
"3498-53_2"	"SL001713"	"IL-17"	"Interleukin-17A"	"6"	"52186387"	"52190638"	"IL17A"	"3605"	"Q16552"	"NA"	"NA"	"NA"	"NA"	"NA"	"secukinumab"	"diagnosis|unspecified application"	"Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080)."	""	"TRUE"
"3499-77_2"	"SL004350"	"IL-17B"	"Interleukin-17B"	"5"	"149371324"	"149404202"	"IL17B"	"27190"	"Q9UHF5"	""	""	""	""	""	""	""	"Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1."	""	"TRUE"
"3503-4_2"	"SL003179"	"Integrin a1b1"	"Integrin alpha-I: beta-1 complex"	"10|5"	"32900319|52787896"	"33005792|52959210"	"ITGA1|ITGB1"	"3672|3688"	"P56199|P05556"	"Integrin-mediated cell adhesion|Regulation of Actin Cytoskeleton|Signaling of Hepatocyte Growth Factor Receptor"	"Arf6 trafficking events|Beta1 integrin cell surface interactions|CXCR4-mediated signaling events|Integrin family cell surface interactions|Plexin-D1 Signaling|Signaling events mediated by PRL|Signaling events mediated by TCPTP|VEGFR3 signaling in lymphatic endothelium"	""	"CHL1 interactions|Integrin cell surface interactions|Laminin interactions|Other semaphorin interactions|Platelet Adhesion to exposed collagen|Smooth Muscle Contraction"	""	""	""	"Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.|Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion."	"417"	"TRUE"
"3504-58_2"	"SL004536"	"LEAP-1"	"Hepcidin"	"19"	"35280716"	"35285143"	"HAMP"	"57817"	"P81172"	"iron metabolism in placenta"	""	""	""	""	""	""	"Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes (PubMed:22306005)."	""	"TRUE"
"3505-6_2"	"SL000507"	"Lymphotoxin a1/b2"	"Lymphotoxin alpha1:beta2"	"6"	"31562695"	"31658827"	"LTA|LTB"	"4049|4050"	"P01374|Q06643"	""	""	""	""	"TNFR -> NF-kB signaling|TNFRSF1A -> AP-1/ATF/TP53 signaling|TNFRSF1A -> CREB/ELK-SRF signaling|TNFRSF1A -> STAT signaling"	""	"prognosis|safety"	"Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.|Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional."	""	"TRUE"
"3506-49_1"	"SL000508"	"Lymphotoxin a2/b1"	"Lymphotoxin alpha2:beta1"	"6"	"31562695"	"31658827"	"LTA|LTB"	"4049|4050"	"P01374|Q06643"	"Apoptosis"	"IL2 signaling events mediated by STAT5|IL4-mediated signaling events"	""	""	"CD8+ T-cell Activation|Cell Death Mediated by Cytotoxic Cells|TNFR -> AP-1/ATF/TP53 signaling|TNFR -> CREB/ELK-SRF signaling|TNFR -> NF-kB signaling|TNFRSF1A -> AP-1/ATF/TP53 signaling|TNFRSF1A -> CREB/ELK-SRF signaling|TNFRSF1A -> STAT signaling|Th1 Cell Differentiation"	""	"prognosis|safety"	"Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.|Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional."	""	"TRUE"
"3508-78_3"	"SL003187"	"MDC"	"C-C motif chemokine 22"	"16"	"57358772"	"57366190"	"CCL22"	"6367"	"O00626"	""	""	""	"Chemokine receptors bind chemokines"	"Dectin-1 (CLEC7A) Signaling"	""	"unspecified application"	"May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active."	""	"TRUE"
"3509-1_1"	"SL003190"	"MIP-5"	"C-C motif chemokine 15"	"17"	"35996440"	"36002080"	"CCL15"	"6359"	"Q16663"	""	""	""	""	"CCR1 -> STAT signaling|Nociception-related CCR1 expression targets|Summarized nociception-related expression targets"	""	""	"Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine A15."	"33|366|395"	"TRUE"
"3514-49_2"	"SL004008"	"Proteinase-3"	"Myeloblastin"	"19"	"840960"	"848180"	"PRTN3"	"5657"	"P24158"	""	"C-MYB transcription factor network"	""	"Common Pathway of Fibrin Clot Formation"	""	""	"unspecified application"	"Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters."	""	"TRUE"
"3516-60_2"	"SL004712"	"SDF-1"	"Stromal cell-derived factor 1"	"10"	"44370165"	"44386493"	"CXCL12"	"6387"	"P48061"	"Lymphocyte TarBase|Muscle cell TarBase"	"CXCR4-mediated signaling events|HIF-1-alpha transcription factor network|Syndecan-4-mediated signaling events"	""	"Chemokine receptors bind chemokines|G alpha (i) signalling events|Nuclear signaling by ERBB4"	"CXCR4 -> STAT signaling"	""	"diagnosis|efficacy|prognosis|unspecified application"	"Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation."	""	"TRUE"
"3518-54_2"	"SL004015"	"TAFI"	"Carboxypeptidase B2"	"13"	"46053186"	"46105076"	"CPB2"	"1361"	"Q96IY4"	"Complement and Coagulation Cascades"	""	""	"Metabolism of Angiotensinogen to Angiotensins"	""	""	""	"Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin."	"38|117"	"TRUE"
"3519-3_2"	"SL003196"	"TARC"	"C-C motif chemokine 17"	"16"	"57404767"	"57416062"	"CCL17"	"6361"	"Q92583"	""	"IL4-mediated signaling events"	""	"Chemokine receptors bind chemokines"	""	""	""	"Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4."	"279|377|433"	"TRUE"
"3520-58_1"	"SL000089"	"TGF-b3"	"Transforming growth factor beta-3"	"14"	"75958099"	"75982991"	"TGFB3"	"7043"	"P10600"	"MAPK signaling pathway"	"ALK1 signaling events|Glypican 1 network|TGF-beta receptor signaling"	""	"ECM proteoglycans|Molecules associated with elastic fibres|Platelet degranulation"	"Cell Cycle|TGFBR -> AP-1 signaling|TGFBR -> ATF/GADD/MAX/TP53 signaling|TGFBR -> CREB/ELK-SRF signaling|TGFBR -> MEF/MYOD/MYOG signaling|TGFBR/BMPR -> SMAD2/3 signaling"	""	""	"Involved in embryogenesis and cell differentiation."	""	"TRUE"
"3521-16_2"	"SL000589"	"TSH"	"Thyroid Stimulating Hormone"	"1|6"	"115029824|87085498"	"115034309|87095406"	"CGA|TSHB"	"1081|12372"	"P01215|P01222"	"TSH signaling pathway"	""	""	"G alpha (s) signalling events|Glycoprotein hormones|Hormone ligand-binding receptors|Thyroxine biosynthesis"	""	""	""	"Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.|Indispensable for the control of thyroid structure and metabolism."	""	"TRUE"
"3522-57_1"	"SL000615"	"Vasoactive Intestinal Peptide"	"Vasoactive Intestinal Peptide"	"6"	"152750798"	"152759765"	"VIP"	"7432"	"P01282"	"IL-6 signaling pathway"	""	""	"G alpha (s) signalling events"	"VIPR -> CREB/CEBP signaling"	""	"efficacy"	"VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder."	""	"TRUE"
"3534-14_2"	"SL003862"	"CD40 ligand, soluble"	"CD40 ligand"	"X"	"136648193"	"136660390"	"CD40LG"	"959"	"P29965"	"Inflammatory Response Pathway"	"Beta2 integrin cell surface interactions|CD40/CD40L signaling|Calcineurin-regulated NFAT-dependent transcription in lymphocytes|Calcium signaling in the CD4+ TCR pathway|IL4-mediated signaling events"	""	"Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"	"Activation of Immunoglobulin Class-Switch Recombination|Model of T-cell Maturation|Nociception-related IL1B expression targets|Peripheral T-cell Tolerance Overview|Regulatory T-cell Differentiation|T-cell Receptor Signaling|T-cell-Dependent B-cell Activation|TNFR -> AP-1/ATF/TP53 signaling|TNFR -> CREB/ELK-SRF signaling|TNFR -> NF-kB signaling|TNFRSF5 -> STAT signaling|TNFRSF5/13B -> NFATC1 signaling|TNFRSF5/6 -> RB1/E2F signaling|Th1 Cell Differentiation|Th17 Cell Differentiation|Th2 Cell Differentiation|V(D)J Recombination Activation"	""	"diagnosis|efficacy|unspecified application"	"Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching."	""	"TRUE"
"3535-84_1"	"SL004367"	"DKK1"	"Dickkopf-related protein 1"	"10"	"52314296"	"52318042"	"DKK1"	"22943"	"O94907"	""	"Direct p53 effectors|Presenilin action in Notch and Wnt signaling|Regulation of nuclear beta catenin signaling and target gene transcription|Validated targets of C-MYC transcriptional repression|Wnt signaling network"	""	"TCF dependent signaling in response to WNT|misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling|negative regulation of TCF-dependent signaling by WNT ligand antagonists"	""	""	"efficacy|prognosis|unspecified application"	"Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease."	""	"TRUE"
"3538-26_1"	"SL009216"	"dopa decarboxylase"	"Aromatic-L-amino-acid decarboxylase"	"7"	"50458436"	"50565457"	"DDC"	"1644"	"P20711"	"Biogenic Amine Synthesis|Nicotine Activity on Dopaminergic Neurons|SIDS Susceptibility Pathways|Tryptophan metabolism"	""	"dopamine biosynthesis"	"Catecholamine biosynthesis|Serotonin and melatonin biosynthesis"	"GALR1/2/3 -> neurotransmitter metabolism"	"carbidopa/entacapone/levodopa|carbidopa/levodopa|S(-)-carbidopa|L-dopa"	"diagnosis"	"Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine."	""	"TRUE"
"3554-24_1"	"SL004258"	"Adiponectin"	"Adiponectin"	"3"	"186842690"	"186858463"	"ADIPOQ"	"9370"	"Q15848"	"AMPK signaling|Adipogenesis|Type II diabetes mellitus"	""	""	"Transcriptional regulation of white adipocyte differentiation"	""	""	"diagnosis|efficacy|prognosis|response to therapy|safety|unspecified application"	"Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW."	""	"TRUE"
"3580-25_8"	"SL000249"	"a1-Antitrypsin"	"Alpha-1-antitrypsin"	"14"	"94376747"	"94390693"	"SERPINA1"	"5265"	"P01009"	"Complement and Coagulation Cascades"	"FOXA1 transcription factor network|p73 transcription factor network"	""	"Platelet degranulation"	""	""	"diagnosis|unspecified application"	"Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin."	"282|320"	"TRUE"
"3581-53_3"	"SL000251"	"a2-HS-Glycoprotein"	"Alpha-2-HS-glycoprotein"	"3"	"186612923"	"186621318"	"AHSG"	"197"	"P02765"	""	"BMP receptor signaling"	""	""	""	""	"unspecified application"	"Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions."	"100"	"TRUE"
"3583-54_1"	"SL005392"	"Arylsulfatase A"	"Arylsulfatase A"	"22"	"50622754"	"50628173"	"ARSA"	"410"	"P15289"	"NA"	"NA"	"NA"	"NA"	"NA"	""	""	"Hydrolyzes cerebroside sulfate."	""	"TRUE"
"3585-54_4"	"SL009341"	"BASI"	"Basigin"	"19"	"571309"	"583493"	"BSG"	"682"	"P35613"	"Matrix Metalloproteinases"	"Syndecan-1-mediated signaling events"	""	"Basigin interactions|Degradation of the extracellular matrix|Integrin cell surface interactions|Pyruvate metabolism"	""	""	"disease progression|prognosis|response to therapy"	"Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes."	""	"TRUE"
"3587-53_1"	"SL007056"	"BMP10"	"Bone morphogenetic protein 10"	"2"	"68865481"	"68871517"	"BMP10"	"27302"	"O95393"	"NA"	"NA"	"NA"	"NA"	"NA"	""	""	"Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines."	""	"TRUE"
"3590-8_3"	"SL000311"	"C1s"	"Complement C1s subcomponent"	"12"	"6988259"	"7071032"	"C1S"	"716"	"P09871"	"Complement Activation, Classical Pathway|Complement and Coagulation Cascades"	""	""	"Classical antibody-mediated complement activation|Initial triggering of complement"	"Classical Complement Pathway"	"SERPING1"	""	"C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4."	"98|259"	"TRUE"
"3591-51_3"	"SL004865"	"Cadherin-6"	"Cadherin-6"	"5"	"31193750"	"31329146"	"CDH6"	"1004"	"P55285"	"Neural Crest Differentiation"	""	""	"Adherens junctions interactions"	""	""	"diagnosis"	"Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types."	""	"TRUE"
"3592-4_3"	"SL010489"	"CAMK1"	"Calcium/calmodulin-dependent protein kinase type 1"	"3"	"9757342"	"9769992"	"CAMK1"	"8536"	"Q14012"	"Calcium Regulation in the Cardiac Cell"	""	""	""	"EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG signaling|GABA(B)R -> postsynaptic inhibition|NPY1R -> CRH/POMC production|NeuropeptideYR -> ATF/CREB signaling|VasopressinR1 -> MEF/MYOD/NFATC/MYOG signaling|VasopressinR2 -> MEF/MYOD/NFATC/MYOG signaling"	""	""	"Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I."	"17|79|413|438"	"TRUE"
"3593-72_3"	"SL003711"	"Caspase-3"	"Caspase-3"	"4"	"184627696"	"184649509"	"CASP3"	"836"	"P42574"	"Alzheimers Disease|Apoptosis|Apoptosis Modulation and Signaling|Apoptosis Modulation by HSP70|DNA damage response|FAS pathway and Stress induction of HSP regulation|Integrated Breast Cancer Pathway|Integrated Cancer pathway|MAPK signaling pathway|Prolactin Signaling Pathway|TNF alpha Signaling Pathway|TWEAK Signaling Pathway|miRNA regulation of DNA Damage Response"	"Calcineurin-regulated NFAT-dependent transcription in lymphocytes|Caspase Cascade in Apoptosis|FAS (CD95) signaling pathway|HIV-1 Nef: Negative effector of Fas and TNF-alpha|LPA receptor mediated events|Posttranslational regulation of adherens junction stability and dissassembly|Role of Calcineurin-dependent NFAT signaling in lymphocytes|Syndecan-2-mediated signaling events|p75(NTR)-mediated signaling"	""	"Activation of DNA fragmentation factor|Activation of caspases through apoptosome-mediated cleavage|Apoptotic cleavage of cell adhesion proteins|Apoptotic cleavage of cellular proteins|Caspase-mediated cleavage of cytoskeletal proteins|Degradation of the extracellular matrix|Ligand-independent caspase activation via DCC|NADE modulates death signalling|SMAC binds to IAPs|SMAC-mediated dissociation of IAP:caspase complexes|Signaling by Hippo|Stimulation of the cell death response by PAK-2p34"	"Apoptosis|Cell Death Mediated by Cytotoxic Cells|Cleavage of Lamina in Apoptosis|Natural Killer Cell Activation through C-type Lectin-like Receptors|Natural Killer Cell Activation through ITAM-Containing Receptors|Natural Killer Cell Activation through ITSM-Containing Receptors|Peripheral T-cell Tolerance Overview|TNFRSF6 -> FOXO3A signaling"	"emricasan"	"diagnosis|disease progression|efficacy|unspecified application"	"Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage."	"416"	"TRUE"
"3594-6_5"	"SL007121"	"CATE"	"Cathepsin E"	"1"	"206009264"	"206023909"	"CTSE"	"1510"	"P14091"	""	""	""	"MHC class II antigen presentation"	""	""	"prognosis"	"May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain."	""	"TRUE"
"3600-2_3"	"SL006029"	"Chitotriosidase-1"	"Chitotriosidase-1"	"1"	"203212827"	"203273641"	"CHIT1"	"1118"	"Q13231"	""	""	""	""	""	""	"efficacy"	"Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity."	"20|169"	"TRUE"
"3601-54_3"	"SL008936"	"CHL1"	"Neural cell adhesion molecule L1-like protein"	"3"	"196596"	"409417"	"CHL1"	"10752"	"O00533"	""	""	""	"CHL1 interactions"	""	""	""	"Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane (By similarity)."	""	"TRUE"
"3603-60_4"	"SL007640"	"CLC7A"	"C-type lectin domain family 7 member A"	"12"	"10116777"	"10130258"	"CLEC7A"	"64581"	"Q9BXN2"	"NA"	"NA"	"NA"	"NA"	"NA"	""	""	"Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity)."	""	"TRUE"
"3604-6_4"	"SL006694"	"CNDP1"	"Beta-Ala-His dipeptidase"	"18"	"74534440"	"74587212"	"CNDP1"	"84735"	"Q96KN2"	"NA"	"NA"	"NA"	"NA"	"NA"	""	""	"Preferential hydrolysis of the beta-Ala-|-His dipeptide (carnosine), and also anserine, Xaa-|-His dipeptides and other dipeptides including homocarnosine."	"280"	"TRUE"
"3605-77_4"	"SL011049"	"MASP3"	"Mannan-binding lectin serine protease 1"	"3"	"187217285"	"187292022"	"MASP1"	"5648"	"P48740"	"Complement Activation, Classical Pathway|Complement and Coagulation Cascades"	""	""	"Ficolins bind to repetitive carbohydrate structures on the target cell surface|Initial triggering of complement|Lectin pathway of complement activation|Scavenging by Class A Receptors"	"Lectin-Induced Complement Pathway"	""	""	"Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5."	"276"	"TRUE"
"3606-2_1"	"SL004120"	"Discoidin domain receptor 2"	"Discoidin domain-containing receptor 2"	"1"	"162631373"	"162787400"	"DDR2"	"4921"	"Q16832"	"NA"	"NA"	"NA"	"NA"	"NA"	"regorafenib"	""	"Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing."	""	"TRUE"
"3607-71_1"	"SL009412"	"DKK3"	"Dickkopf-related protein 3"	"11"	"11963106"	"12009769"	"DKK3"	"27122"	"Q9UBP4"	""	""	""	""	""	""	""	"Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity)."	"343"	"TRUE"
"3608-12_1"	"SL008916"	"DPP2"	"Dipeptidyl peptidase 2"	"9"	"137110542"	"137115177"	"DPP7"	"29952"	"Q9UHL4"	"NA"	"NA"	"NA"	"NA"	"NA"	""	""	"Plays an important role in the degradation of some oligopeptides."	""	"TRUE"
"3611-70_4"	"SL004060"	"Endothelin-converting enzyme 1"	"Endothelin-converting enzyme 1"	"1"	"21217247"	"21345504"	"ECE1"	"1889"	"P42892"	"SIDS Susceptibility Pathways"	""	""	""	""	""	""	"Converts big endothelin-1 to endothelin-1."	"203"	"TRUE"
"3612-6_4"	"SL004845"	"EphB4"	"Ephrin type-B receptor 4"	"7"	"100802565"	"100827521"	"EPHB4"	"2050"	"P54760"	""	"EPHB forward signaling|Ephrin B reverse signaling|EphrinB-EPHB pathway"	""	"EPH-Ephrin signaling|EPH-ephrin mediated repulsion of cells|EPHB-mediated forward signaling|Ephrin signaling"	""	"XL647"	""	"Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis."	""	"TRUE"
"3613-62_5"	"SL010462"	"FCN1"	"Ficolin-1"	"9"	"134905890"	"134917963"	"FCN1"	"2219"	"O00602"	""	""	""	"Ficolins bind to repetitive carbohydrate structures on the target cell surface|Initial triggering of complement|Lectin pathway of complement activation"	""	""	""	"Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097). Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage."	"241"	"TRUE"
"3616-3_5"	"SL008504"	"GNS"	"N-acetylglucosamine-6-sulfatase"	"12"	"64713445"	"64759447"	"GNS"	"2799"	"P15586"	""	""	""	"Keratan sulfate degradation|Lysosome Vesicle Biogenesis|MPS IIID - Sanfilippo syndrome D"	""	""	""	"Hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate."	""	"TRUE"
"3617-80_4"	"SL006512"	"HGFA"	"Hepatocyte growth factor activator"	"4"	"3441887"	"3449495"	"HGFAC"	"3083"	"Q04756"	""	""	""	""	""	""	""	"Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form."	"114|403"	"TRUE"
"3620-67_5"	"SL007806"	"IL22RA1"	"Interleukin-22 receptor subunit alpha-1"	"1"	"24119771"	"24143121"	"IL22RA1"	"58985"	"Q8N6P7"	"NA"	"NA"	"NA"	"NA"	"NA"	""	""	"Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation."	""	"TRUE"
"3622-33_4"	"SL008909"	"LGMN"	"Legumain"	"14"	"92703807"	"92748702"	"LGMN"	"5641"	"Q99538"	""	""	""	"MHC class II antigen presentation|Trafficking and processing of endosomal TLR|Vitamin D (calciferol) metabolism"	"MHC2-Mediated Antigen Presentation"	""	""	"Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system."	""	"TRUE"
"3623-84_4"	"SL007059"	"LY86"	"Lymphocyte antigen 86"	"6"	"6588108"	"6654983"	"LY86"	"9450"	"O95711"	""	""	""	"Toll Like Receptor 4 (TLR4) Cascade"	""	""	""	"May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression (By similarity)."	""	"TRUE"
"3624-3_4"	"SL011069"	"Marapsin"	"Serine protease 27"	"16"	"2712418"	"2720551"	"PRSS27"	"83886"	"Q9BQR3"	""	""	""	""	""	""	""	"Secreted"	"82"	"TRUE"
"3627-71_4"	"SL010376"	"MMEL2"	"Membrane metallo-endopeptidase-like 1"	"1"	"2590639"	"2632990"	"MMEL1"	"79258"	"Q495T6"	""	""	""	""	""	""	""	"Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond (By similarity)."	""	"TRUE"
"3628-3_4"	"SL010501"	"MP2K2"	"Dual specificity mitogen-activated protein kinase kinase 2"	"19"	"4090321"	"4124129"	"MAP2K2"	"5605"	"P36507"	"B Cell Receptor Signaling Pathway|EGF/EGFR Signaling Pathway|EPO Receptor Signaling|Focal Adhesion|Hypothetical Network for Drug Addiction|IL-1 signaling pathway|IL-2 Signaling pathway|IL-5 signaling pathway|IL-6 signaling pathway|IL-7 signaling pathway|IL-9 signaling pathway|Insulin Signaling|Integrin-mediated cell adhesion|Kit receptor signaling pathway|Leptin signaling pathway|MAPK Cascade|MAPK signaling pathway|MicroRNAs in cardiomyocyte hypertrophy|Prolactin Signaling Pathway|Regulation of Actin Cytoskeleton|Regulation of toll-like receptor signaling pathway|Serotonin HTR1 Group and FOS Pathway|Serotonin Receptor 2 and ELK-SRF/GATA4 signaling|Serotonin Receptor 4/6/7 and NR3C Signaling|Signaling of Hepatocyte Growth Factor Receptor|TCR Signaling Pathway|TGF beta Signaling Pathway|Toll-like receptor signaling pathway"	"CXCR3-mediated signaling events|Cellular roles of Anthrax toxin|Ceramide signaling pathway|Downstream signaling in naïve CD8+ T cells|Endothelins|ErbB1 downstream signaling|ErbB2/ErbB3 signaling events|Fc-epsilon receptor I signaling in mast cells|GMCSF-mediated signaling events|IL2-mediated signaling events|Netrin-mediated signaling events|Nongenotropic Androgen signaling|PDGFR-beta signaling pathway|SHP2 signaling|Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)|Signaling events mediated by Stem cell factor receptor (c-Kit)|Signaling events mediated by VEGFR1 and VEGFR2|mTOR signaling pathway"	""	"ERK2 activation|MEK activation|RAF phosphorylates MEK|Signal transduction by L1|Signaling by FGFR1|Signaling by FGFR2|Signaling by FGFR3|Signaling by FGFR4|Uptake and function of anthrax toxins"	"ADRA1 -> prostaglandin generation|ADRA1 -> vasoconstriction|ADRA1A -> IL6 production|ADRA2C/ADRB2 -> synaptic endocytosis|ADRA2C/ADRB2 -> vasoconstriction|ADRB1 -> prostaglandin generation|AGER ->  CREB/SP1 signaling|AdenosineR -> AP-1 signaling|AdrenergicRa -> ELK-SRF signaling|AdrenergicRa -> STAT3 signaling|AdrenergicRb -> CREB signaling|AdrenergicRb -> STAT3 signaling|AngiopoietinR -> AP-1 signaling|AngiotensinR -> CREB/ELK-SRF/TP53 signaling|B-cell receptor -> AP-1 signaling|BDKRB1/2 -> prostaglandin generation|CD19 ->  AP-1/ELK-SRF signaling|CD38 ->  NF-kB signaling|CD8+ T-cell Activation|CHRM1 -> IL2 production|CHRM1/2/3 -> vascular motility|CHRNA7 -> NOS1 production|CNR1/2 -> IL1B/2/4/6/10 production|CannabinoidR -> AP-1/EGR signaling|CholecystokininR -> ELK-SRF signaling|CholinergicRm -> CREB/ELK-SRF signaling|CholinergicRn ->  CREB signaling|DopamineR1 -> CREB/ELK-SRF signaling|DopamineR2 -> AP-1/CREB/ELK-SRF signaling|EDG2 -> ELK-SRF signaling|EDG3/5 -> AP-1/ELK-SRF signaling|EDNRA/B -> vascular motility|EGFR -> AP-1/ATF2 signaling|EGFR -> AP-1/CREB/ELK-SRF/MYC signaling|EGFR -> SMAD1 signaling|EGFR/ERBB2 -> HIF1A signaling|EGFR/ERBB2 -> TP53 signaling|ERBB2/3 -> EP300/ETS/ETV/SP1 signaling|EctodysplasinR -> AP-1 signaling|EndothelinRa -> AP-1/CREB signaling|EndothelinRb -> AP-1/CREB/ELK-SRF signaling|ErythropoietinR -> AP-1/CREB/MYC signaling|ErythropoietinR -> ELK-SRF/FOS signaling|FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling|FGFR -> RUNX2 signaling|FSHR -> CREB/ELK-SRF/GATA4 signaling|FcIgER -> ELK-SRF signaling|FibronectinR -> AP-1/ELK-SRF/SREBF signaling|GABA(B)R -> postsynaptic inhibition|GALR1/2/3 -> POMC/NPY production|GDNF -> HSF1 signaling|GHR -> ELK-SRF/MYC signaling|GNRHR -> ELK-SRF signaling|GRM1/5 -> CREB signaling|GlucagonR -> CREB/ELK-SRF/SP1 signaling|HGFR -> AP-1/CREB/MYC signaling|HRH2/4 -> IL6/10 production|HTR1 -> IL6 production|HTR4/6/7 -> cation channels|HTR5 -> TNF production|HTR7 -> IL6 production|ICAM1 -> AP-1/CREB/ELK-SRF signaling|IGF1R -> ELK-SRF/HIF1A/MYC/SREBF signaling|IL1R -> NF-kB signaling|IL2R -> ELK-SRF/MYC signaling|IL4R -> ELK-SRF/HMGY signaling|IL6R -> CEBP/ELK-SRF signaling|IL8R -> CREB/EGR signaling|InsulinR -> ELK-SRF/SREBF signaling|KIT -> MITF signaling|LeptinR -> ELK-SRF signaling|Model of T-cell Maturation|NCAM1 -> CREB/ELK-SRF/MYC signaling|NGFR -> AP-1/CEBPB/CREB/ELK-SRF/TP53 signaling|NMDA receptors -> Ca2+/CREB activation/PGE2 synthesis|NPY1R -> CRH/POMC production|NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling|Natural Killer Cell Activation|Natural Killer Cell Activation through C-type Lectin-like Receptors|Natural Killer Cell Activation through ITAM-Containing Receptors|Natural Killer Cell Activation through ITSM-Containing Receptors|NeuropeptideYR -> ATF/CREB signaling|NeurotensinR -> ELK-SRF/AP-1/EGR signaling|Nociception-related DRD1/5 expression targets|Nociception-related DRD2 expression targets|Nociception-related IL1B expression targets|Nociception-related IL6 expression targets|Nociception-related NTSR1 expression targets|Notch -> TCF3 signaling|OPRK -> pain perception|OpioidR -> CREB/ELK-SRF/STAT3 signaling|OxytocinR -> ELK-SRF/GATA/AP-1 signaling|P2RY11/13/14 -> IL8/10 production|PDGFR -> AP-1/MYC signaling|PECAM -> SP1 signaling|PTAFR -> AP-1/ATF1/CREB/ERK-SRF signaling|PTGER1/4 -> vascular motility|PTGER2/3 -> inflammation-related expression targets|PTGIR -> IL6 production|PTPRC -> BCL6 signaling|ProstaglandinFR -> ATF1/ELK-SRF/CREB signaling|ProstaglandinIR -> ATF1/ELK-SRF/CREB signaling|Regulation of potassium flux|Regulatory T-cell Differentiation|SELE -> ELK-SRF signaling|SerotoninR1 -> FOS signaling|SerotoninR2 -> ELK-SRF/GATA4 signaling|SerotoninR4/6/7 -> NR3C signaling|Summarized nociception-related expression targets|Summarized vascular motility pathway|T-cell Receptor Signaling|T-cell receptor -> AP-1 signaling|T-cell-Dependent B-cell Activation|T-cell-Independent B-cell Activation|TNFR -> AP-1/ATF/TP53 signaling|TNFR -> CREB/ELK-SRF signaling|TNFRSF1A -> AP-1/ATF/TP53 signaling|TNFRSF1A -> CREB/ELK-SRF signaling|TNFRSF6 -> HSF1 signaling|TachykininR -> ELK-SRF signaling|Th1 Cell Differentiation|Th2 Cell Differentiation|ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling|ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling|ThrombopoietinR -> SP1 signaling|ThromboxaneR -> CREB signaling|UrokinaseR -> ELK-SRF signaling|VEGFR -> AP-1/CREB/MYC signaling|VEGFR -> ATF/CREB/ELK-SRF signaling|VIPR -> CREB/CEBP signaling|VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling|VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling"	"selumetinib|trametinib|dabrafenib/trametinib"	""	"Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity)."	"119|155|328"	"TRUE"
"3629-60_4"	"SL006805"	"MRCKB"	"Serine/threonine-protein kinase MRCK beta"	"14"	"102932379"	"103057462"	"CDC42BPB"	"9578"	"Q9Y5S2"	""	""	""	""	""	""	""	"Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A."	""	"TRUE"
"3630-27_4"	"SL004804"	"Nectin-like protein 1"	"Cell adhesion molecule 3"	"1"	"159171609"	"159203313"	"CADM3"	"57863"	"Q8N126"	""	""	""	"Adherens junctions interactions|Nectin/Necl trans heterodimerization"	""	""	""	"Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity)."	""	"TRUE"
"3633-70_1"	"SL008193"	"NID2"	"Nidogen-2"	"14"	"52004803"	"52069228"	"NID2"	"22795"	"Q14112"	"NA"	"NA"	"NA"	"NA"	"NA"	""	""	"Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix interactions."	""	"TRUE"
"3634-5_4"	"SL005491"	"OBCAM"	"Opioid-binding protein/cell adhesion molecule"	"11"	"132414977"	"133532519"	"OPCML"	"4978"	"Q14982"	""	""	""	""	""	""	"diagnosis"	"Binds opioids in the presence of acidic lipids; probably involved in cell contact."	""	"TRUE"
"3635-76_4"	"SL010530"	"OCAD1"	"OCIA domain-containing protein 1"	"4"	"48805212"	"48861817"	"OCIAD1"	"54940"	"Q9NX40"	""	""	""	""	""	""	"NA"	"EBI-2683029"	"333"	"TRUE"
"3636-37_4"	"SL007327"	"OLR1"	"Oxidized low-density lipoprotein receptor 1"	"12"	"10158301"	"10172138"	"OLR1"	"4973"	"P78380"	""	""	""	"Cell surface interactions at the vascular wall"	""	""	"unspecified application"	"Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria."	""	"TRUE"
"3640-14_3"	"SL005263"	"RAP"	"alpha-2-macroglobulin receptor-associated protein"	"4"	"3506376"	"3532559"	"LRPAP1"	"4043"	"P30533"	""	"Lissencephaly gene (LIS1) in neuronal migration and development|Reelin signaling pathway|Signaling events mediated by the Hedgehog family"	""	""	""	""	""	"Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330."	"59|182|242"	"TRUE"
"3641-49_4"	"SL000566"	"RBP"	"Retinol-binding protein 4"	"10"	"93591687"	"93601744"	"RBP4"	"5950"	"P02753"	"NA"	"NA"	"NA"	"NA"	"NA"	""	"unspecified application"	"Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli."	""	"TRUE"
"3642-4_1"	"SL008588"	"SLAF5"	"SLAM family member 5"	"1"	"160541095"	"160579516"	"CD84"	"8832"	"Q9UIB8"	""	""	""	"Cell surface interactions at the vascular wall"	""	""	""	"Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B (By similarity). Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seem be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A-dependent pathway. May serve as a marker for hematopoietic progenitor cells (PubMed:11564780, PubMed:12115647. PubMed:12928397, PubMed:12962726, PubMed:16037392) Required for a prolonged T-cell:B-cell contact, optimal T follicular helper function, and germinal center formation. In germinal centers involved in maintaining B-cell tolerance and in preventing autoimmunity (By similarity). In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1 (PubMed:22068234). In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2 (By similarity)."	""	"TRUE"
"3644-5_4"	"SL010381"	"Soggy-1"	"Dickkopf-like protein 1"	"19"	"49361783"	"49375116"	"DKKL1"	"27120"	"Q9UK85"	""	""	""	""	""	""	""	"Secreted"	""	"TRUE"
"3646-7_4"	"SL010518"	"TEC"	"Tyrosine-protein kinase Tec"	"4"	"48135783"	"48269864"	"TEC"	"7006"	"P42680"	"B Cell Receptor Signaling Pathway|Kit receptor signaling pathway|Prolactin Signaling Pathway"	"EPO signaling pathway|Signaling events mediated by Stem cell factor receptor (c-Kit)"	""	"FCERI mediated Ca+2 mobilization|Interleukin-3, 5 and GM-CSF signaling|Signaling by SCF-KIT"	""	""	""	"Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC. TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets. Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC regulates also FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 'Tyr-215'. May also be involved in the regulation of osteoclast differentiation."	""	"TRUE"
"3647-49_4"	"SL018625"	"TLR4:MD-2 complex"	"Toll-like receptor 4:Lymphocyte antigen 96 complex"	"8|9"	"73991352|117704332"	"74029087|117716871"	"TLR4|LY96"	"7099|23643"	"O00206|Q9Y6Y9"	"Regulation of toll-like receptor signaling pathway|Toll-like receptor signaling pathway"	"Endogenous TLR signaling"	""	"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon|IKK complex recruitment mediated by RIP1|IRAK4 deficiency (TLR2/4)|Ligand-dependent caspase activation|MyD88 deficiency (TLR2/4)|MyD88-independent TLR3/TLR4 cascade|MyD88:Mal cascade initiated on plasma membrane|TRAF6 mediated induction of TAK1 complex|TRIF-mediated programmed cell death|Toll Like Receptor 4 (TLR4) Cascade"	"TLR -> AP-1 signaling|TLR4 -> IRF signaling|TLR4/5/7/9 -> NF-kB signaling"	""	""	"Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:9237759, PubMed:10835634). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+). Responses triggered by Ni(2+) require non-conserved histidines and are, therefore, species-specific (PubMed:20711192). In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed:23880187).|Binds bacterial lipopolysaccharide (LPS) (PubMed:17803912, PubMed:17569869). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030). Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581). Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581)."	"28|74|448"	"TRUE"
"3651-50_5"	"SL003201"	"VEGF sR2"	"Vascular endothelial growth factor receptor 2"	"4"	"55078477"	"55125589"	"KDR"	"3791"	"P35968"	"Angiogenesis|Focal Adhesion|angiogenesis overview"	"Beta3 integrin cell surface interactions|HIF-2-alpha transcription factor network|Integrins in angiogenesis|Notch-mediated HES/HEY network|S1P1 pathway|SHP2 signaling|Signaling events mediated by TCPTP|Signaling events mediated by VEGFR1 and VEGFR2|VEGF and VEGFR signaling network"	""	"EPHA-mediated growth cone collapse|Integrin cell surface interactions|Neurophilin interactions with VEGF and VEGFR|VEGF binds to VEGFR leading to receptor dimerization|VEGFA-VEGFR2 Pathway|VEGFR2 mediated cell proliferation"	"Transcytosis|VEGFR -> AP-1/CREB/MYC signaling|VEGFR -> ATF/CREB/ELK-SRF signaling|VEGFR -> CTNNB signaling|VEGFR -> CTNND signaling|VEGFR -> FOXO3A signaling|VEGFR -> NFATC signaling|VEGFR -> STAT signaling"	"AEE 788|sunitinib|cediranib|pazopanib|axitinib|XL647|CEP 7055|brivanib alaninate|CHIR-265|tivozanib|motesanib|OSI-930|telatinib|ramucirumab|cabozantinib|nintedanib|regorafenib|bortezomib/sorafenib|lapatinib/pazopanib|dexamethasone/lenalidomide/sorafenib|bevacizumab/sorafenib|cabozantinib/erlotinib|docetaxel/ramucirumab|vatalanib|sorafenib|vandetanib|pegaptanib"	"disease progression|efficacy|prognosis|response to therapy|safety"	"Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC."	"28|186"	"TRUE"
"3654-27_4"	"SL007531"	"BMPER"	"BMP-binding endothelial regulator protein"	"7"	"33904911"	"34155872"	"BMPER"	"168667"	"Q8N8U9"	""	""	""	""	""	""	""	"Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes."	""	"TRUE"
"3656-9_1"	"SL004864"	"Cadherin-12"	"Cadherin-12"	"5"	"21750673"	"22853622"	"CDH12"	"1010"	"P55289"	""	""	""	"Adherens junctions interactions"	""	""	""	"Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types."	""	"TRUE"
"3657-74_3"	"SL004720"	"Calcineurin B a"	"Calcineurin subunit B type 1"	"2"	"68178857"	"68256237"	"PPP3R1"	"5534"	"P63098"	"Alzheimers Disease|Energy Metabolism|MAPK signaling pathway|TFs Regulate miRNAs related to cardiac hypertrophy"	"Calcium signaling in the CD4+ TCR pathway|Downstream signaling in naïve CD8+ T cells|IL12 signaling mediated by STAT4|IL12-mediated signaling events|Role of Calcineurin-dependent NFAT signaling in lymphocytes"	""	"Activation of BAD and translocation to mitochondria|CLEC7A (Dectin-1) induces NFAT activation|Ca2+ pathway|DARPP-32 events|FCERI mediated Ca+2 mobilization"	"Cell Cycle"	"cyclosporin A"	""	"Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity."	""	"TRUE"
"3665-64_3"	"SL007471"	"COLEC12"	"Collectin-12"	"18"	"316740"	"500722"	"COLEC12"	"81035"	"Q5KU26"	"NA"	"NA"	"NA"	"NA"	"NA"	""	""	"Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid beta in Alzheimer disease."	""	"TRUE"
"3666-17_4"	"SL006830"	"complement factor H-related 5"	"Complement factor H-related protein 5"	"1"	"196977556"	"197009674"	"CFHR5"	"81494"	"Q9BXR6"	""	""	""	""	""	""	""	"Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH."	"98|301|326"	"TRUE"
"3676-15_3"	"SL003679"	"IGF-II receptor"	"Cation-independent mannose-6-phosphate receptor"	"6"	"159969099"	"160113507"	"IGF2R"	"3482"	"P11717"	"Adipocyte TarBase|Epithelium TarBase|Leukocyte TarBase|Lymphocyte TarBase|Muscle cell TarBase"	""	""	"Golgi Associated Vesicle Biogenesis"	"Golgi to Endosome Transport|Transcytosis"	""	""	"Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4."	"80|127|315|358"	"TRUE"
"3681-87_3"	"SL003919"	"kallikrein 14"	"Kallikrein-14"	"19"	"51077495"	"51084245"	"KLK14"	"43847"	"Q9P0G3"	""	""	""	""	""	""	"diagnosis|prognosis"	"Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis."	""	"TRUE"
"3684-78_3"	"SL004580"	"Macrophage scavenger receptor"	"Macrophage scavenger receptor types I and II"	"8"	"16107878"	"16567490"	"MSR1"	"4481"	"P21757"	""	""	""	"Scavenging by Class A Receptors"	""	""	""	"Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize acetylated LDL."	"333"	"TRUE"
"3685-53_1"	"SL010466"	"MFRP"	"Membrane frizzled-related protein"	"11"	"119338934"	"119346673"	"MFRP"	"83552"	"Q9BY79"	""	""	""	""	""	""	""	"May play a role in eye development."	""	"TRUE"
"3700-15_4"	"SL000467"	"IgG"	"Immunoglobulin G"	"14"	"105668113"	"106538344"	"IGHG1|IGHG2|IGHG3|IGHG4|IGK@|IGL@"	"3500|3501|3502|3503|50802|3535"	"P01857"	"NA"	"NA"	"NA"	"NA"	"NA"	""	""	"EBI-356114"	""	"TRUE"
"3707-12_2"	"SL000254"	"Albumin"	"Serum albumin"	"4"	"73397114"	"73421412"	"ALB"	"213"	"P02768"	"Folate Metabolism|Selenium Pathway|Vitamin B12 Metabolism"	"FOXA2 and FOXA3 transcription factor networks"	""	"HDL-mediated lipid transport|Platelet degranulation|Recycling of bile acids and salts|Scavenging of heme from plasma|Transport of organic anions"	""	""	"diagnosis|efficacy|prognosis|safety|unspecified application"	"Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc."	""	"TRUE"
"3708-62_1"	"SL000252"	"a2-Macroglobulin"	"Alpha-2-macroglobulin"	"12"	"9067664"	"9116229"	"A2M"	"2"	"P01023"	"Complement and Coagulation Cascades|IL-6 signaling pathway"	"IL6-mediated signaling events"	""	"Degradation of the extracellular matrix|HDL-mediated lipid transport|Intrinsic Pathway of Fibrin Clot Formation|Platelet degranulation|Rho GTPase cycle"	"Extracellular Matrix Turnover"	""	""	"Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase."	""	"TRUE"
"3709-4_2"	"SL000617"	"ALT"	"Alanine aminotransferase 1"	"8"	"144502973"	"144507174"	"GPT"	"2875"	"P24298"	"Alanine and aspartate metabolism"	""	"L-alanine degradation via transaminase pathway"	"Amino acid synthesis and interconversion (transamination)"	""	""	""	"Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity)."	""	"TRUE"
"3710-49_2"	"SL000268"	"Angiostatin"	"Angiostatin"	"6"	"160702238"	"160753315"	"PLG"	"5340"	"P00747"	"Blood Clotting Cascade|Complement and Coagulation Cascades|Folate Metabolism|Selenium Pathway|Vitamin B12 Metabolism"	"Angiopoietin receptor Tie2-mediated signaling|Syndecan-4-mediated signaling events|Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling|amb2 Integrin signaling|p75(NTR)-mediated signaling"	""	"Activation of Matrix Metalloproteinases|Degradation of the extracellular matrix|Dissolution of Fibrin Clot|Platelet degranulation|Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)|Signaling by PDGF"	"Coagulation Cascade|ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling|ThrombinR -> NF-kB signaling|ThrombinR -> STAT1 signaling"	"tenecteplase|PLAT|tranexamic acid|aprotinin|6-aminocaproic acid|reteplase"	"diagnosis"	"Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells."	"425"	"TRUE"
"3714-49_2"	"SL000382"	"CK-MB"	"Creatine kinase M-type:Creatine kinase B-type heterodimer"	"14|19"	"103519659|45306414"	"103523111|45322977"	"CKB|CKM"	"1152|1158"	"P12277|P06732"	"Urea cycle and metabolism of amino groups"	"Regulation of retinoblastoma protein"	""	"Creatine metabolism"	""	""	"efficacy|safety|unspecified application"	"Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.|Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa."	""	"TRUE"
"3716-63_2"	"SL000458"	"IFN-g R1"	"Interferon gamma receptor 1"	"6"	"137197484"	"137219449"	"IFNGR1"	"3459"	"P15260"	"NA"	"NA"	"NA"	"NA"	"NA"	"interferon gamma-1b"	""	"Associates with IFNGR2 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:7615558, PubMed:2971451, PubMed:7617032, PubMed:10986460). Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:7673114)."	""	"TRUE"
"3719-2_2"	"SL000076"	"p27Kip1"	"Cyclin-dependent kinase inhibitor 1B"	"12"	"12715058"	"12722371"	"CDKN1B"	"1027"	"P46527"	"Cell cycle|DNA damage response|DNA damage response (only ATM dependent)|Epithelium TarBase|ErbB signaling pathway|G1 to S cell cycle control|IL-7 signaling pathway|Lymphocyte TarBase|Muscle cell TarBase|Ovarian Infertility Genes|Senescence and Autophagy|TSH signaling pathway|miRNA regulation of DNA Damage Response|miRNAs involved in DDR"	"AP-1 transcription factor network|C-MYB transcription factor network|Class I PI3K signaling events mediated by Akt|E2F transcription factor network|FOXA1 transcription factor network|FoxO family signaling|Integrins in angiogenesis|Notch-mediated HES/HEY network|Regulation of RhoA activity|Regulation of Telomerase|Regulation of retinoblastoma protein|RhoA signaling pathway|Validated targets of C-MYC transcriptional repression"	""	"AKT phosphorylates targets in the cytosol|Constitutive Signaling by AKT1 E17K in Cancer|Cyclin A:Cdk2-associated events at S phase entry|Cyclin D associated events in G1|Cyclin E associated events during G1/S transition|DNA Damage/Telomere Stress Induced Senescence|Orc1 removal from chromatin|RHO GTPases activate CIT|SCF(Skp2)-mediated degradation of p27/p21|Senescence-Associated Secretory Phenotype (SASP)|p53-Dependent G1 DNA Damage Response"	"Cell Cycle"	""	"diagnosis|disease progression|efficacy|prognosis|response to therapy"	"Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry."	""	"TRUE"
"3722-49_2"	"SL002517"	"TNF-a"	"Tumor necrosis factor"	"6"	"31557707"	"31654641"	"TNF"	"7124"	"P01375"	"NA"	"NA"	"NA"	"NA"	"NA"	"adalimumab|etanercept|infliximab|certolizumab|golimumab|infliximab/methotrexate|dexamethasone/thalidomide|dexamethasone/pomalidomide|cyclophosphamide/dexamethasone/thalidomide|golimumab/methotrexate|bortezomib/dexamethasone/thalidomide|rituximab/thalidomide|bortezomib/thalidomide|prednisone/thalidomide|adalimumab/methotrexate|pomalidomide|thalidomide"	"diagnosis|disease progression|efficacy|prognosis|response to therapy|safety|unspecified application"	"Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918)."	""	"TRUE"
"3723-1_2"	"SL000306"	"BNP-32"	"Brain natriuretic peptide 32"	"1"	"11857464"	"11858931"	"NPPB"	"4879"	"P16860"	"MicroRNAs in cardiomyocyte hypertrophy"	""	""	""	""	""	"diagnosis|efficacy|prognosis|safety|unspecified application"	"Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3."	""	"TRUE"
"3726-62_4"	"SL003970"	"PTH"	"Parathyroid hormone"	"11"	"13492055"	"13496181"	"PTH"	"5741"	"P01270"	"NA"	"NA"	"NA"	"NA"	"NA"	""	"efficacy|safety"	"PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells."	""	"TRUE"
"3727-35_1"	"SL011509"	"PYY"	"Peptide YY"	"17"	"43952738"	"44004469"	"PYY"	"5697"	"P10082"	""	""	""	"G alpha (i) signalling events|Peptide ligand-binding receptors"	""	""	"efficacy"	"This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility."	""	"TRUE"
"3728-52_2"	"SL000570"	"Secretin"	"Secretin"	"11"	"626431"	"627431"	"SCT"	"6343"	"P09683"	""	""	""	"G alpha (s) signalling events|Glucagon-type ligand receptors"	""	""	""	"Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach."	""	"TRUE"
"3729-16_2"	"SL011510"	"Somatostatin-28"	"Somatostatin-28"	"3"	"187668906"	"187670399"	"SST"	"6750"	"P61278"	"NA"	"NA"	"NA"	"NA"	"NA"	""	"efficacy"	"Somatostatin inhibits the release of somatotropin."	""	"TRUE"
"3730-81_2"	"SL011448"	"TNR4"	"Tumor necrosis factor receptor superfamily member 4"	"1"	"1211326"	"1214138"	"TNFRSF4"	"7293"	"P43489"	""	"Downstream signaling in naïve CD8+ T cells"	""	""	""	""	"diagnosis"	"Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity."	""	"TRUE"
"3736-60_3"	"SL003993"	"BMP-6"	"Bone morphogenetic protein 6"	"6"	"7726797"	"7881422"	"BMP6"	"654"	"P22004"	"NA"	"NA"	"NA"	"NA"	"NA"	""	""	"Induces cartilage and bone formation."	""	"TRUE"
"3737-6_3"	"SL000346"	"Cathepsin H"	"Cathepsin H"	"15"	"78921058"	"78949574"	"CTSH"	"1512"	"P09668"	"NA"	"NA"	"NA"	"NA"	"NA"	""	""	"Important for the overall degradation of proteins in lysosomes."	""	"TRUE"
"3738-54_1"	"SL002684"	"CSF-1"	"Macrophage colony-stimulating factor 1"	"1"	"109910242"	"109930992"	"CSF1"	"1435"	"P09603"	"NA"	"NA"	"NA"	"NA"	"NA"	""	"diagnosis|disease progression|efficacy|prognosis|unspecified application"	"Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance."	""	"TRUE"
"3739-72_4"	"SL000542"	"gpIIbIIIa"	"Integrin alpha-IIb: beta-3 complex"	"17|17"	"44372180|47253846"	"44389505|47311816"	"ITGA2B|ITGB3"	"3674|3690"	"P08514|P05106"	"NA"	"NA"	"NA"	"NA"	"NA"	""	""	"Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.|Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity)."	""	"TRUE"
"3741-4_3"	"SL000481"	"IL-5"	"Interleukin-5"	"5"	"132541444"	"132556838"	"IL5"	"3567"	"P05113"	"NA"	"NA"	"NA"	"NA"	"NA"	""	"diagnosis|efficacy|response to therapy"	"Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells."	"82"	"TRUE"
"3743-1_2"	"SL000645"	"MMP-10"	"Stromelysin-2"	"11"	"102770503"	"102780628"	"MMP10"	"4319"	"P09238"	"NA"	"NA"	"NA"	"NA"	"NA"	"marimastat"	""	"Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase."	""	"TRUE"
"3758-68_3"	"SL003974"	"Activated Protein C"	"Activated Protein C"	"2"	"127418427"	"127429246"	"PROC"	"5624"	"P04070"	"Complement and Coagulation Cascades"	"Beta2 integrin cell surface interactions"	""	"Cell surface interactions at the vascular wall|Common Pathway of Fibrin Clot Formation|Gamma-carboxylation of protein precursors|Intrinsic Pathway of Fibrin Clot Formation|Removal of aminoterminal propeptides from gamma-carboxylated proteins|Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus"	"Coagulation Cascade|Vitamin K metabolism"	""	"diagnosis|efficacy"	"Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265). Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845)."	""	"TRUE"
"3761-4_2"	"SL000027"	"COX-2"	"Prostaglandin G/H synthase 2"	"1"	"186671791"	"186680427"	"PTGS2"	"5743"	"P35354"	"Eicosanoid Synthesis|Prostaglandin Synthesis and Regulation|Selenium Pathway"	"C-MYB transcription factor network|Calcineurin-regulated NFAT-dependent transcription in lymphocytes|Calcium signaling in the CD4+ TCR pathway|S1P1 pathway|Signaling mediated by p38-alpha and p38-beta"	"prostaglandin biosynthesis"	"Nicotinamide salvaging|Synthesis of 15-eicosatetraenoic acid derivatives|Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"	"Nociception-related CCR1 expression targets|Nociception-related IL1B expression targets|Nociception-related IL6 expression targets|Omega-6-fatty acid metabolism|Summarized nociception-related expression targets"	"acetaminophen/pentazocine|acetaminophen/clemastine/pseudoephedrine|aspirin/butalbital/caffeine|acetaminophen/caffeine/dihydrocodeine|aspirin/hydrocodone|aspirin/oxycodone|acetaminophen/aspirin/caffeine|aspirin/pravastatin|acetaminophen/dexbrompheniramine/pseudoephedrine|aspirin/meprobamate|aspirin/caffeine/propoxyphene|aspirin/butalbital/caffeine/codeine|aspirin/caffeine/dihydrocodeine|chlorpheniramine/ibuprofen/pseudoephedrine|licofelone|menatetrenone|icosapent|suprofen|lornoxicam|tiaprofenic acid|lumiracoxib|tenoxicam|naproxen/sumatriptan|ibuprofen/phenylephrine|acetaminophen/aspirin/codeine|esomeprazole/naproxen|aspirin/esomeprazole|aspirin/dipyridamole/telmisartan|famotidine/ibuprofen|aspirin/dabigatran etexilate|diclofenac/omeprazole|chlorpheniramine/ibuprofen/phenylephrine|dexamethasone/pomalidomide|sulindac/tamoxifen|sulindac/toremifene|raloxifene/sulindac|ketorolac/phenylephrine|diclofenac/misoprostol|acetaminophen/butalbital/caffeine|hydrocodone/ibuprofen|acetaminophen/hydrocodone|acetaminophen/tramadol|acetaminophen/codeine|acetaminophen/oxycodone|acetaminophen/propoxyphene|niflumic acid|nitroaspirin|ketoprofen|diclofenac|etoricoxib|naproxen|meclofenamic acid|pomalidomide|meloxicam|celecoxib|dipyrone|nimesulide|acetaminophen|mefenamic acid|diflunisal|ibuprofen|GW406381X|phenylbutazone|indomethacin|sulfasalazine|piroxicam|valdecoxib|aspirin|carprofen|zomepirac|rofecoxib|aspirin/caffeine/orphenadrine|acetaminophen/butalbital|balsalazide|aspirin/dipyridamole|acetaminophen/butalbital/caffeine/codeine|racemic flurbiprofen|phenacetin|sulindac|nabumetone|etodolac|tolmetin|ketorolac|oxaprozin|mesalamine|salsalate|fenoprofen|salicylic acid|acetaminophen/caffeine/chlorpheniramine/hydrocodone/phenylephrine|bromfenac"	"diagnosis|disease progression|efficacy|prognosis|unspecified application"	"Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis."	""	"TRUE"
"3766-51_4"	"SL004304"	"STX1a"	"Syntaxin-1A"	"7"	"73699206"	"73719672"	"STX1A"	"6804"	"Q16623"	"Monoamine Transport|Serotonin Transporter Activity"	"Effects of Botulinum toxin"	""	"Acetylcholine Neurotransmitter Release Cycle|Dopamine Neurotransmitter Release Cycle|GABA synthesis, release, reuptake and degradation|Glutamate Neurotransmitter Release Cycle|Insulin processing|Norepinephrine Neurotransmitter Release Cycle|Regulation of insulin secretion|Serotonin Neurotransmitter Release Cycle|Toxicity of botulinum toxin type C (BoNT/C)"	"Exocytosis"	""	""	"Plays a role in hormone and neurotransmitter exocytosis (By similarity). Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm."	""	"TRUE"
"3773-15_4"	"SL003200"	"sTie-2"	"Angiopoietin-1 receptor, soluble"	"9"	"27109141"	"27230175"	"TEK"	"7010"	"Q02763"	"Angiogenesis|Wnt Signaling Pathway|angiogenesis overview"	"Angiopoietin receptor Tie2-mediated signaling|SHP2 signaling"	""	"Tie2 Signaling"	"AngiopoietinR -> AP-1 signaling|AngiopoietinR -> FOXO signaling|AngiopoietinR -> STAT signaling"	"cabozantinib|regorafenib|ponatinib|cabozantinib/erlotinib|vandetanib"	"efficacy"	"Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. ANGPT1 signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Signaling is modulated by ANGPT2 that has lower affinity for TEK, can promote TEK autophosphorylation in the absence of ANGPT1, but inhibits ANGPT1-mediated signaling by competing for the same binding site. Signaling is also modulated by formation of heterodimers with TIE1, and by proteolytic processing that gives rise to a soluble TEK extracellular domain. The soluble extracellular domain modulates signaling by functioning as decoy receptor for angiopoietins. TEK phosphorylates DOK2, GRB7, GRB14, PIK3R1; SHC1 and TIE1."	"69|185"	"TRUE"
"3795-6_2"	"SL004642"	"ADAM 9"	"Disintegrin and metalloproteinase domain-containing protein 9"	"8"	"38996869"	"39105144"	"ADAM9"	"8754"	"Q13443"	""	""	""	"Collagen degradation"	""	""	"efficacy|prognosis"	"Probable zinc protease. May mediate cell-cell or cell-matrix interactions. Isoform 2 displays alpha-secretase activity for APP."	""	"TRUE"
"3796-79_2"	"SL007642"	"ANGL4"	"Angiopoietin-related protein 4"	"19"	"8363289"	"8374373"	"ANGPTL4"	"51129"	"Q9BY76"	""	""	""	"PPARA activates gene expression|Transcriptional regulation of white adipocyte differentiation"	""	""	""	"Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation (By similarity)."	""	"TRUE"
"3797-1_1"	"SL000638"	"Cadherin-2"	"Cadherin-2"	"18"	"27950966"	"28177446"	"CDH2"	"1000"	"P19022"	"Neural Crest Differentiation"	"FGF signaling pathway|N-cadherin signaling events|Posttranslational regulation of adherens junction stability and dissassembly|Signaling events mediated by PTP1B"	""	"Adherens junctions interactions|CDO in myogenesis"	"Adherens Junction Assembly (Cadherins)"	"N-ac-CHAVC-NH2"	"diagnosis|prognosis"	"Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity)."	""	"TRUE"
"3798-71_1"	"SL005508"	"Carbonic anhydrase 9"	"Carbonic anhydrase 9"	"9"	"35673856"	"35681159"	"CA9"	"768"	"Q16790"	""	"HIF-1-alpha transcription factor network"	""	"Regulation of gene expression by Hypoxia-inducible Factor|Reversible hydration of carbon dioxide"	""	"girentuximab|I 131 chimeric G250|Y 90 chimeric G250|methazolamide|hydrochlorothiazide|acetazolamide|trichloromethiazide|chlorothiazide|chlorthalidone|benzthiazide|sulfacetamide|topiramate"	"diagnosis|efficacy|prognosis"	"Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia."	""	"TRUE"
"3799-11_2"	"SL004867"	"Carbonic anhydrase III"	"Carbonic anhydrase 3"	"8"	"85373436"	"85449040"	"CA3"	"761"	"P07451"	""	""	""	"Reversible hydration of carbon dioxide"	""	"methazolamide|hydrochlorothiazide|acetazolamide|trichloromethiazide|chlorothiazide|chlorthalidone|benzthiazide|sulfacetamide|topiramate"	""	"Reversible hydration of carbon dioxide."	""	"TRUE"
"3800-71_2"	"SL000377"	"CK-BB"	"Creatine kinase B-type"	"14"	"103519659"	"103523111"	"CKB"	"1152"	"P12277"	"Urea cycle and metabolism of amino groups"	""	""	"Creatine metabolism"	""	""	"safety"	"Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa."	""	"TRUE"
"3802-50_1"	"SL007888"	"Cystatin-S"	"Cystatin-S"	"20"	"23685640"	"23689040"	"CST4"	"1472"	"P01036"	""	""	""	""	""	""	""	"This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non-competitively."	""	"TRUE"
"3803-10_2"	"SL008382"	"CYTD"	"Cystatin-D"	"20"	"23875935"	"23879750"	"CST5"	"1473"	"P28325"	"Endochondral Ossification"	""	""	""	""	""	""	"Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B."	"90|399"	"TRUE"
"3804-66_2"	"SL007403"	"DMP1"	"Dentin matrix acidic phosphoprotein 1"	"4"	"87650307"	"87664361"	"DMP1"	"1758"	"Q13316"	"NA"	"NA"	"NA"	"NA"	"NA"	""	""	"May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite."	""	"TRUE"
"3805-16_2"	"SL010458"	"Endocan"	"Endothelial cell-specific molecule 1"	"5"	"54977864"	"55022671"	"ESM1"	"11082"	"Q9NQ30"	""	""	""	""	""	""	""	"Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions."	""	"TRUE"
"3806-55_1"	"SL004844"	"EphA5"	"Ephrin type-A receptor 5"	"4"	"65319563"	"65670495"	"EPHA5"	"2044"	"P54756"	""	"EPHA forward signaling|Ephrin A  reverse signaling|EphrinA-EPHA pathway"	""	"EPH-Ephrin signaling|EPH-ephrin mediated repulsion of cells|EPHA-mediated growth cone collapse"	""	""	""	"Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity)."	""	"TRUE"
"3807-1_2"	"SL007651"	"FGF23"	"Fibroblast growth factor 23"	"12"	"4368227"	"4379728"	"FGF23"	"8074"	"Q9GZV9"	"Osteoblast Signaling|Regulation of Actin Cytoskeleton"	"FGF signaling pathway"	""	"Activated point mutants of FGFR2|Constitutive Signaling by Aberrant PI3K in Cancer|FGFR1c and Klotho ligand binding and activation|FGFR1c ligand binding and activation|FGFR2c ligand binding and activation|FGFR3 mutant receptor activation|FGFR3c ligand binding and activation|FGFR4 ligand binding and activation|FRS-mediated FGFR1 signaling|FRS-mediated FGFR2 signaling|FRS-mediated FGFR3 signaling|FRS2-mediated FGFR4 signaling|Negative regulation of FGFR1 signaling|Negative regulation of FGFR2 signaling|Negative regulation of FGFR3 signaling|Negative regulation of FGFR4 signaling|PI-3K cascade:FGFR1|PI-3K cascade:FGFR2|PI-3K cascade:FGFR3|PI-3K cascade:FGFR4|PI3K Cascade|PIP3 activates AKT signaling|Phospholipase C-mediated cascade, FGFR2|Phospholipase C-mediated cascade, FGFR3|Phospholipase C-mediated cascade, FGFR4|Phospholipase C-mediated cascade: FGFR1|SHC-mediated cascade:FGFR1|SHC-mediated cascade:FGFR2|SHC-mediated cascade:FGFR3|SHC-mediated cascade:FGFR4|Signaling by FGFR1 mutants|Signaling by FGFR2 mutants|Signaling by FGFR3 mutants|Signaling by FGFR4 mutants|Signaling by activated point mutants of FGFR1|Signaling by activated point mutants of FGFR3"	"FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling|FGFR -> RUNX2 signaling|FGFR3 -> STAT signaling"	""	""	"Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization."	""	"TRUE"
"3808-76_2"	"SL003990"	"FGFR-2"	"Fibroblast growth factor receptor 2"	"10"	"121478334"	"121598458"	"FGFR2"	"2263"	"P21802"	"Angiogenesis|MicroRNAs in cardiomyocyte hypertrophy|Neural Crest Differentiation|Regulation of Actin Cytoskeleton"	"FGF signaling pathway"	""	"Activated point mutants of FGFR2|Constitutive Signaling by Aberrant PI3K in Cancer|FGFR2b ligand binding and activation|FGFR2c ligand binding and activation|FRS-mediated FGFR2 signaling|Negative regulation of FGFR2 signaling|PI-3K cascade:FGFR2|PI3K Cascade|PIP3 activates AKT signaling|Phospholipase C-mediated cascade, FGFR2|SHC-mediated cascade:FGFR2|Signaling by FGFR2 amplification mutants|Signaling by FGFR2 mutants|Signaling by FGFR4 mutants"	"FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling|FGFR -> RUNX2 signaling"	"nintedanib|regorafenib|dexamethasone/thalidomide|bortezomib/dexamethasone/thalidomide|rituximab/thalidomide|bortezomib/thalidomide|prednisone/thalidomide|thalidomide|palifermin"	"diagnosis|response to therapy"	"Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1."	""	"TRUE"
"3809-1_2"	"SL004063"	"FGFR-3"	"Fibroblast growth factor receptor 3"	"4"	"1793307"	"1808872"	"FGFR3"	"2261"	"P22607"	"Endochondral Ossification|Neural Crest Differentiation|Regulation of Actin Cytoskeleton"	"FGF signaling pathway"	""	"Constitutive Signaling by Aberrant PI3K in Cancer|FGFR3 mutant receptor activation|FGFR3b ligand binding and activation|FGFR3c ligand binding and activation|FRS-mediated FGFR3 signaling|Negative regulation of FGFR3 signaling|PI-3K cascade:FGFR3|PI3K Cascade|PIP3 activates AKT signaling|Phospholipase C-mediated cascade, FGFR3|SHC-mediated cascade:FGFR3|Signaling by FGFR3 mutants|Signaling by activated point mutants of FGFR3|t(4"	"FGFR3 -> STAT signaling"	"pazopanib|nintedanib"	"prognosis"	"Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B. Secreted isoform 3 retains its capacity to bind FGF1 and FGF2 and hence may interfere with FGF signaling."	""	"TRUE"
"3810-50_2"	"SL006912"	"FGR"	"Tyrosine-protein kinase Fgr"	"1"	"27612064"	"27635277"	"FGR"	"2268"	"P09769"	"Focal Adhesion"	"Alpha-synuclein signaling|CXCR4-mediated signaling events|Class I PI3K signaling events|EPHA forward signaling|Ephrin B reverse signaling|Glypican 1 network|IL8- and CXCR1-mediated signaling events|IL8- and CXCR2-mediated signaling events|PDGFR-beta signaling pathway|Regulation of p38-alpha and p38-beta|Signaling events mediated by PTP1B|Thromboxane A2 receptor signaling|amb2 Integrin signaling"	""	"FCGR activation|Platelet sensitization by LDL"	"MacrophageR -> CEBPB/NF-kB signaling"	"vemurafenib"	""	"Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1."	""	"TRUE"
"3811-1_2"	"SL002086"	"Ficolin-3"	"Ficolin-3"	"1"	"27369112"	"27374824"	"FCN3"	"8547"	"O75636"	"NA"	"NA"	"NA"	"NA"	"NA"	""	""	"May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota."	""	"TRUE"
"3813-3_2"	"SL006913"	"FYN"	"Tyrosine-protein kinase Fyn"	"6"	"111660332"	"111873452"	"FYN"	"2534"	"P06241"	"B Cell Receptor Signaling Pathway|Focal Adhesion|IL-2 Signaling pathway|IL-3 Signaling Pathway|IL-7 signaling pathway|Integrin-mediated cell adhesion|Leptin signaling pathway|Prolactin Signaling Pathway|TCR Signaling Pathway"	"Alpha-synuclein signaling|Angiopoietin receptor Tie2-mediated signaling|CXCR4-mediated signaling events|Class I PI3K signaling events|E-cadherin signaling in keratinocytes|EPHA forward signaling|Ephrin A  reverse signaling|Ephrin B reverse signaling|ErbB4 signaling events|Fc-epsilon receptor I signaling in mast cells|Glypican 1 network|IL2-mediated signaling events|Nephrin/Neph1 signaling in the kidney podocyte|Netrin-mediated signaling events|PDGFR-beta signaling pathway|Posttranslational regulation of adherens junction stability and dissassembly|Reelin signaling pathway|Regulation of p38-alpha and p38-beta|Signaling events mediated by PTP1B|Signaling events mediated by VEGFR1 and VEGFR2|Signaling events mediated by focal adhesion kinase|Syndecan-3-mediated signaling events|TCR signaling in naïve CD4+ T cells|TCR signaling in naïve CD8+ T cells|Thromboxane A2 receptor signaling|amb2 Integrin signaling"	""	"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers|CD209 (DC-SIGN) signaling|CD28 co-stimulation|CD28 dependent PI3K/Akt signaling|CD28 dependent Vav1 pathway|CRMPs in Sema3A signaling|CTLA4 inhibitory signaling|Cell surface interactions at the vascular wall|Constitutive Signaling by Aberrant PI3K in Cancer|DAP12 signaling|DCC mediated attractive signaling|Dectin-2 family|EPH-Ephrin signaling|EPH-ephrin mediated repulsion of cells|EPHA-mediated growth cone collapse|EPHB-mediated forward signaling|Ephrin signaling|FCGR activation|GPVI-mediated activation cascade|NCAM signaling for neurite out-growth|Nef and signal transduction|Nephrin interactions|Netrin mediated repulsion signals|PECAM1 interactions|PIP3 activates AKT signaling|Platelet Adhesion to exposed collagen|Regulation of KIT signaling|Regulation of signaling by CBL|Role of LAT2/NTAL/LAB on calcium mobilization|SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion|Sema3A PAK dependent Axon repulsion|Signaling by ERBB2|Signaling by SCF-KIT|VEGFA-VEGFR2 Pathway"	"Adherens Junction Assembly (Cadherins)|CD2 -> NFATC1 signaling|CHRNA7 -> NOS1 production|CholinergicRn ->  CREB signaling|EphrinR -> STAT signaling|IL7R -> FOXO/NF-kB signaling|NCAM1 -> CREB/ELK-SRF/MYC signaling|Natural Killer Cell Activation|Natural Killer Cell Activation through ITAM-Containing Receptors|Natural Killer Cell Activation through ITSM-Containing Receptors|Natural Killer Cell Activation through Integrins and non-ITAM-Containing Receptors|Natural Killer Cell Inhibitory Receptor Signaling|PTPRC -> BCL6 signaling|Peripheral T-cell Tolerance Overview|Regulatory T-cell Differentiation|T-cell Receptor Signaling|T-cell receptor -> AP-1 signaling|T-cell receptor -> ATF/CREB signaling|T-cell receptor -> CREBBP signaling|T-cell receptor -> NF-kB signaling|T-cell receptor -> NFATC signaling|T-cell receptor -> STAT signaling|Th1 Cell Differentiation|Th17 Cell Differentiation|Th2 Cell Differentiation|UrokinaseR -> ELK-SRF signaling"	"dasatinib"	"efficacy"	"Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1."	""	"TRUE"
"3814-63_1"	"SL007423"	"IL-11 RA"	"Interleukin-11 receptor subunit alpha"	"9"	"34650702"	"34661892"	"IL11RA"	"3590"	"Q14626"	"NA"	"NA"	"NA"	"NA"	"NA"	"oprelvekin"	""	"Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number."	""	"TRUE"
"3815-14_1"	"SL007620"	"IL-12 RB2"	"Interleukin-12 receptor subunit beta-2"	"1"	"67307364"	"67396900"	"IL12RB2"	"3595"	"Q99665"	""	"IL12-mediated signaling events|IL27-mediated signaling events"	""	""	"CD8+ T-cell Activation|IL12R -> NF-kB/NFATC signaling|IL12R -> STAT signaling|Th1 Cell Differentiation|Th17 Cell Differentiation"	""	""	"Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production."	""	"TRUE"
"3817-18_1"	"SL007358"	"KPCT"	"Protein kinase C theta type"	"10"	"6427143"	"6580301"	"PRKCQ"	"5588"	"Q04759"	"Calcium Regulation in the Cardiac Cell|G Protein Signaling Pathways|Insulin Signaling|Myometrial Relaxation and Contraction Pathways|TCR Signaling Pathway|Wnt Signaling Pathway|Wnt Signaling Pathway and Pluripotency|miRs in Muscle Cell Differentiation"	"Calcineurin-regulated NFAT-dependent transcription in lymphocytes|Downstream signaling in naïve CD8+ T cells|Endothelins|Role of Calcineurin-dependent NFAT signaling in lymphocytes|TCR signaling in naïve CD4+ T cells|TCR signaling in naïve CD8+ T cells|Thromboxane A2 receptor signaling"	""	"Apoptotic cleavage of cellular proteins|Downstream TCR signaling|Effects of PIP2 hydrolysis|FCERI mediated NF-kB activation|G alpha (z) signalling events|Inactivation, recovery and regulation of the phototransduction cascade|Netrin-1 signaling"	"CD8+ T-cell Activation|Natural Killer Cell Activation|Natural Killer Cell Activation through C-type Lectin-like Receptors|Natural Killer Cell Activation through ITAM-Containing Receptors|Natural Killer Cell Activation through ITSM-Containing Receptors|Peripheral T-cell Tolerance Overview|Regulatory T-cell Differentiation|T-cell Receptor Signaling|T-cell receptor -> NF-kB signaling|Th1 Cell Differentiation|Th17 Cell Differentiation|Th2 Cell Differentiation|V(D)J Recombination Activation"	"ingenol mebutate"	"diagnosis"	"Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates to the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in 'outside-in' signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at 'Ser-504' and 'Ser-532' and negatively regulates its ability to phosphorylate PKB/AKT1."	""	"TRUE"
"3820-68_2"	"SL010503"	"MAPK2"	"MAP kinase-activated protein kinase 2"	"1"	"206684944"	"206734283"	"MAPKAPK2"	"9261"	"P49137"	"FAS pathway and Stress induction of HSP regulation|IL-1 signaling pathway|MAPK signaling pathway|Serotonin HTR1 Group and FOS Pathway|Serotonin Receptor 2 and ELK-SRF/GATA4 signaling|Serotonin Receptor 4/6/7 and NR3C Signaling|p38 MAPK Signaling Pathway"	"IL2-mediated signaling events|Signaling events mediated by VEGFR1 and VEGFR2|Signaling mediated by p38-alpha and p38-beta|Trk receptor signaling mediated by the MAPK pathway|p38 signaling mediated by MAPKAP kinases"	""	"Butyrate Response Factor 1 (BRF1) destabilizes mRNA|CREB phosphorylation|Oxidative Stress Induced Senescence|Regulation of HSF1-mediated heat shock response|Synthesis of Leukotrienes (LT) and Eoxins (EX)|Tristetraprolin (TTP) destabilizes mRNA|VEGFA-VEGFR2 Pathway|activated TAK1 mediates p38 MAPK activation|p38MAPK events"	"ADRA1A -> IL6 production|AdrenergicRa -> ELK-SRF signaling|AngiotensinR -> CREB/ELK-SRF/TP53 signaling|CD19 ->  AP-1/ELK-SRF signaling|CHRM1 -> IL2 production|CNR1/2 -> IL1B/2/4/6/10 production|CannabinoidR -> AP-1/EGR signaling|CholecystokininR -> ELK-SRF signaling|CholinergicRm -> CREB/ELK-SRF signaling|DopamineR1 -> CREB/ELK-SRF signaling|DopamineR2 -> AP-1/CREB/ELK-SRF signaling|EDG2 -> ELK-SRF signaling|EDG3/5 -> AP-1/ELK-SRF signaling|EDNRA/B -> vascular motility|EGFR -> AP-1/CREB/ELK-SRF/MYC signaling|EndothelinRa -> AP-1/CREB signaling|EndothelinRb -> AP-1/CREB/ELK-SRF signaling|ErythropoietinR -> AP-1/CREB/MYC signaling|ErythropoietinR -> ELK-SRF/FOS signaling|FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling|FSHR -> CREB/ELK-SRF/GATA4 signaling|FcIgER -> ELK-SRF signaling|FibronectinR -> AP-1/ELK-SRF/SREBF signaling|GHR -> ELK-SRF/MYC signaling|GNRHR -> ELK-SRF signaling|GRM1/5 -> CREB signaling|GlucagonR -> CREB/ELK-SRF/SP1 signaling|HGFR -> AP-1/CREB/MYC signaling|HTR1 -> IL6 production|HTR5 -> TNF production|HTR7 -> IL6 production|ICAM1 -> AP-1/CREB/ELK-SRF signaling|IGF1R -> ELK-SRF/HIF1A/MYC/SREBF signaling|IL2R -> ELK-SRF/MYC signaling|IL4R -> ELK-SRF/HMGY signaling|IL6R -> CEBP/ELK-SRF signaling|IL8R -> CREB/EGR signaling|InsulinR -> ELK-SRF/SREBF signaling|LeptinR -> ELK-SRF signaling|NGFR -> AP-1/CEBPB/CREB/ELK-SRF/TP53 signaling|NPY1R -> CRH/POMC production|NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling|NeuropeptideYR -> ATF/CREB signaling|NeurotensinR -> ELK-SRF/AP-1/EGR signaling|Nociception-related DRD1/5 expression targets|Nociception-related DRD2 expression targets|Nociception-related NTSR1 expression targets|OpioidR -> CREB/ELK-SRF/STAT3 signaling|OxytocinR -> ELK-SRF/GATA/AP-1 signaling|P2RY11/13/14 -> IL8/10 production|PTAFR -> AP-1/ATF1/CREB/ERK-SRF signaling|PTGIR -> IL6 production|ProstaglandinFR -> ATF1/ELK-SRF/CREB signaling|ProstaglandinIR -> ATF1/ELK-SRF/CREB signaling|SELE -> ELK-SRF signaling|SerotoninR1 -> FOS signaling|SerotoninR2 -> ELK-SRF/GATA4 signaling|SerotoninR4/6/7 -> NR3C signaling|Summarized nociception-related expression targets|T-cell receptor -> ATF/CREB signaling|TGFBR -> CREB/ELK-SRF signaling|TNFR -> CREB/ELK-SRF signaling|TNFRSF1A -> CREB/ELK-SRF signaling|TachykininR -> ELK-SRF signaling|ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling|ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling|UrokinaseR -> ELK-SRF signaling|VEGFR -> AP-1/CREB/MYC signaling|VEGFR -> ATF/CREB/ELK-SRF signaling|VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling|VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling"	""	""	"Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, ELAVL1, HNRNPA0, HSF1, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilize GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3."	"346"	"TRUE"
"3821-28_1"	"SL010504"	"MAPK5"	"MAP kinase-activated protein kinase 5"	"12"	"111841978"	"111902238"	"MAPKAPK5"	"8550"	"Q8IW41"	"MAPK signaling pathway|p38 MAPK Signaling Pathway"	"Signaling mediated by p38-alpha and p38-beta"	""	"Oxidative Stress Induced Senescence"	""	""	""	"Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement."	""	"TRUE"
"3822-54_2"	"SL004765"	"MAPKAPK3"	"MAP kinase-activated protein kinase 3"	"3"	"50611520"	"50649297"	"MAPKAPK3"	"7867"	"Q16644"	"FAS pathway and Stress induction of HSP regulation|Serotonin HTR1 Group and FOS Pathway"	"Signaling mediated by p38-alpha and p38-beta|p38 signaling mediated by MAPKAP kinases"	""	"Oxidative Stress Induced Senescence|VEGFA-VEGFR2 Pathway|activated TAK1 mediates p38 MAPK activation|p38MAPK events"	"ADRA1A -> IL6 production|AngiotensinR -> CREB/ELK-SRF/TP53 signaling|CHRM1 -> IL2 production|CNR1/2 -> IL1B/2/4/6/10 production|CannabinoidR -> AP-1/EGR signaling|CholinergicRm -> CREB/ELK-SRF signaling|DopamineR2 -> AP-1/CREB/ELK-SRF signaling|EDNRA/B -> vascular motility|EGFR -> AP-1/CREB/ELK-SRF/MYC signaling|EndothelinRa -> AP-1/CREB signaling|EndothelinRb -> AP-1/CREB/ELK-SRF signaling|ErythropoietinR -> AP-1/CREB/MYC signaling|FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling|GRM1/5 -> CREB signaling|HGFR -> AP-1/CREB/MYC signaling|HTR1 -> IL6 production|HTR5 -> TNF production|ICAM1 -> AP-1/CREB/ELK-SRF signaling|NGFR -> AP-1/CEBPB/CREB/ELK-SRF/TP53 signaling|NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling|Nociception-related DRD2 expression targets|PTAFR -> AP-1/ATF1/CREB/ERK-SRF signaling|SerotoninR1 -> FOS signaling|Summarized nociception-related expression targets|T-cell receptor -> ATF/CREB signaling|TGFBR -> CREB/ELK-SRF signaling|TNFR -> CREB/ELK-SRF signaling|TNFRSF1A -> CREB/ELK-SRF signaling|ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling|ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling|VEGFR -> AP-1/CREB/MYC signaling|VEGFR -> ATF/CREB/ELK-SRF signaling|VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling|VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling"	""	"unspecified application"	"Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. Also acts as a modulator of Polycomb-mediated repression."	"8|362|410|411"	"TRUE"
"3823-9_1"	"SL010505"	"MATK"	"Megakaryocyte-associated tyrosine-protein kinase"	"19"	"3777970"	"3802129"	"MATK"	"4145"	"P42679"	"Kit receptor signaling pathway"	"Neurotrophic factor-mediated Trk receptor signaling|Signaling events mediated by Stem cell factor receptor (c-Kit)"	""	"Signaling by ERBB2"	""	""	""	"Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation."	""	"TRUE"
"3825-18_2"	"SL010502"	"MK08"	"Mitogen-activated protein kinase 8"	"10"	"48306639"	"48439360"	"MAPK8"	"5599"	"P45983"	"Apoptosis Modulation and Signaling|B Cell Receptor Signaling Pathway|DNA damage response (only ATM dependent)|EBV LMP1 signaling|EGF/EGFR Signaling Pathway|ErbB signaling pathway|FAS pathway and Stress induction of HSP regulation|Focal Adhesion|IL-1 signaling pathway|IL-3 Signaling Pathway|Insulin Signaling|Keap1-Nrf2 Pathway|Kit receptor signaling pathway|Leptin signaling pathway|MAPK signaling pathway|MicroRNAs in cardiomyocyte hypertrophy|NLR proteins|Osteoclast Signaling|Physiological and Pathological Hypertrophy  of the Heart|Prolactin Signaling Pathway|RANKL/RANK Signaling Pathway|Regulation of toll-like receptor signaling pathway|Signaling of Hepatocyte Growth Factor Receptor|TCR Signaling Pathway|TGF beta Signaling Pathway|TNF alpha Signaling Pathway|TWEAK Signaling Pathway|Toll-like receptor signaling pathway|Type II diabetes mellitus|angiogenesis overview"	"ATF-2 transcription factor network|Angiopoietin receptor Tie2-mediated signaling|BCR signaling pathway|CD40/CD40L signaling|CDC42 signaling events|Ceramide signaling pathway|Downstream signaling in naïve CD8+ T cells|EPO signaling pathway|Endothelins|Ephrin B reverse signaling|ErbB1 downstream signaling|ErbB2/ErbB3 signaling events|FAS (CD95) signaling pathway|Fc-epsilon receptor I signaling in mast cells|FoxO family signaling|Glucocorticoid receptor regulatory network|Glypican 3 network|HIV-1 Nef: Negative effector of Fas and TNF-alpha|IL1-mediated signaling events|IL12 signaling mediated by STAT4|IL2-mediated signaling events|JNK signaling in the CD4+ TCR pathway|N-cadherin signaling events|Nephrin/Neph1 signaling in the kidney podocyte|Noncanonical Wnt signaling pathway|Osteopontin-mediated events|PDGFR-beta signaling pathway|RAC1 signaling pathway|Rapid glucocorticoid signaling|Reelin signaling pathway|Regulation of Androgen receptor activity|Retinoic acid receptors-mediated signaling|RhoA signaling pathway|Role of Calcineurin-dependent NFAT signaling in lymphocytes|S1P2 pathway|Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)|Signaling events mediated by Stem cell factor receptor (c-Kit)|Signaling events mediated by focal adhesion kinase|Signaling events regulated by Ret tyrosine kinase|Syndecan-2-mediated signaling events|TRAIL signaling pathway|p53 pathway|p75(NTR)-mediated signaling"	""	"Activation of BIM and translocation to mitochondria|Activation of BMF and translocation to mitochondria|Activation of the AP-1 family of transcription factors|DSCAM interactions|FCERI mediated MAPK activation|JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1|NRAGE signals death through JNK|NRIF signals cell death from the nucleus|Oxidative Stress Induced Senescence"	"ADRA1A -> IL6 production|AngiopoietinR -> AP-1 signaling|Apoptosis|CNR1/2 -> IL1B/2/4/6/10 production|CannabinoidR -> AP-1/EGR signaling|Central T-cell Tolerance|DopamineR2 -> AP-1/CREB/ELK-SRF signaling|EDG3/5 -> AP-1/ELK-SRF signaling|EGFR -> AP-1/ATF2 signaling|EGFR -> AP-1/CREB/ELK-SRF/MYC signaling|EGFR/ERBB2 -> TP53 signaling|EctodysplasinR -> AP-1 signaling|EndothelinRa -> AP-1/CREB signaling|EndothelinRb -> AP-1/CREB/ELK-SRF signaling|EphrinB ->  JUN signaling|ErythropoietinR -> AP-1/CREB/MYC signaling|FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling|FibronectinR -> AP-1/ELK-SRF/SREBF signaling|FrizzledR -> JUN/PAX2 signaling|GDNF -> HSF1 signaling|GNRHR -> ELK-SRF signaling|HGFR -> AP-1/CREB/MYC signaling|NGFR -> AP-1/CEBPB/CREB/ELK-SRF/TP53 signaling|NOD-like Receptors in Pathogen Recognition|NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling|Nociception-related DRD2 expression targets|Notch -> TCF3 signaling|PDGFR -> AP-1/MYC signaling|PTAFR -> AP-1/ATF1/CREB/ERK-SRF signaling|PTGER2/3 -> inflammation-related expression targets|Summarized nociception-related expression targets|T-cell Positive Selection and Neglect-Induced Death|TGFBR -> AP-1 signaling|TLR -> AP-1 signaling|TLR4 Signaling in Leukocytes|TNFR -> AP-1/ATF/TP53 signaling|TNFR -> CREB/ELK-SRF signaling|TNFRSF1A -> AP-1/ATF/TP53 signaling|TNFRSF1A -> CREB/ELK-SRF signaling|TNFRSF6 -> DDIT3 signaling|TNFRSF6 -> HSF1 signaling|ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling|ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling|ThrombopoietinR -> SPI1 signaling|Toll-like Receptors Act through MYD88-TIRAP Signaling|VEGFR -> AP-1/CREB/MYC signaling|VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling|VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling"	"aplidine"	""	"Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins. Loss of this interaction abrogates the acetylation required for replication initiation. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation. Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy. Phosphorylates STMN2 and hence regulates microtubule dynamics, controlling neurite elongation in cortical neurons. In the developing brain, through its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone. Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3 ligase ITCH. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692)."	""	"TRUE"
"3827-22_1"	"SL010509"	"PAK6"	"Serine/threonine-protein kinase PAK 6"	"15"	"40217428"	"40277487"	"PAK6"	"56924"	"Q9NQU5"	"Androgen receptor signaling pathway|Focal Adhesion|Integrin-mediated cell adhesion|Regulation of Actin Cytoskeleton"	""	""	"Activation of Rac"	""	""	""	"Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD."	""	"TRUE"
"3828-54_2"	"SL011071"	"PDGF-CC"	"Platelet-derived growth factor C"	"4"	"156760454"	"156971394"	"PDGFC"	"56034"	"Q9NRA1"	"Focal Adhesion"	"PDGF receptor signaling network"	""	"Signaling by PDGF"	"PDGFR -> AP-1/MYC signaling|PDGFR -> FOXO3A signaling|PDGFR -> STAT signaling"	""	""	"Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function."	""	"TRUE"
"3831-21_1"	"SL003761"	"pTEN"	"Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN"	"10"	"87863113"	"87971930"	"PTEN"	"5728"	"P60484"	"Androgen receptor signaling pathway|DNA damage response (only ATM dependent)|EGF/EGFR Signaling Pathway|Focal Adhesion|Insulin Signaling|Integrated Breast Cancer Pathway|Integrated Cancer pathway|Senescence and Autophagy|Signaling of Hepatocyte Growth Factor Receptor"	"AP-1 transcription factor network|BCR signaling pathway|CXCR4-mediated signaling events|Class I PI3K signaling events|Direct p53 effectors|PDGFR-beta signaling pathway|RhoA signaling pathway|Signaling events mediated by Stem cell factor receptor (c-Kit)|TCR signaling in naïve CD4+ T cells"	""	"Downstream TCR signaling|Negative regulation of the PI3K/AKT network|PIP3 activates AKT signaling|PTEN Loss of Function in Cancer|Synthesis of IP3 and IP4 in the cytosol|Synthesis of PIPs at the plasma membrane|TP53 Regulates Metabolic Genes"	"Adherens Junction Assembly (Cadherins)|T-cell Positive Selection and Neglect-Induced Death|Tight Junction Assembly (Occludin)"	""	"diagnosis|disease progression|efficacy|prognosis|response to therapy"	"Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement."	""	"TRUE"
"3832-51_1"	"SL010514"	"PTK6"	"Protein-tyrosine kinase 6"	"20"	"63528001"	"63537370"	"PTK6"	"5753"	"Q13882"	"EGF/EGFR Signaling Pathway|Focal Adhesion"	""	""	""	""	"vandetanib"	"prognosis"	"Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins: KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors: STAT3 and STAT5A/B and a variety of signaling molecules: ARHGAP35/p190RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. Associates also with a variety of proteins that are likely upstream of PTK6 in various signaling pathways, or for which PTK6 may play an adapter-like role. These proteins include ADAM15, EGFR, ERBB2, ERBB3 and IRS4. In normal or non-tumorigenic tissues, PTK6 promotes cellular differentiation and apoptosis. In tumors PTK6 contributes to cancer progression by sensitizing cells to mitogenic signals and enhancing proliferation, anchorage-independent survival and migration/invasion. Association with EGFR, ERBB2, ERBB3 may contribute to mammary tumor development and growth through enhancement of EGF-induced signaling via BTK/AKT and PI3 kinase. Contributes to migration and proliferation by contributing to EGF-mediated phosphorylation of ARHGAP35/p190RhoGAP, which promotes association with RASA1/p120RasGAP, inactivating RhoA while activating RAS. EGF stimulation resulted in phosphorylation of PNX/Paxillin by PTK6 and activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. PTK6 activates STAT3 and STAT5B to promote proliferation. Nuclear PTK6 may be important for regulating growth in normal epithelia, while cytoplasmic PTK6 might activate oncogenic signaling pathways."	""	"TRUE"
"3833-10_2"	"SL010467"	"RGMA"	"Repulsive guidance molecule A"	"15"	"93035273"	"93089204"	"RGMA"	"56963"	"Q96B86"	"NA"	"NA"	"NA"	"NA"	"NA"	""	""	"Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8."	"71"	"TRUE"
"3835-11_2"	"SL004492"	"TLR2"	"Toll-like receptor 2"	"4"	"153701500"	"153705699"	"TLR2"	"7097"	"O60603"	"Regulation of toll-like receptor signaling pathway|Toll-like receptor signaling pathway"	"Endogenous TLR signaling"	""	"Beta defensins|IRAK4 deficiency (TLR2/4)|MyD88 deficiency (TLR2/4)|MyD88:Mal cascade initiated on plasma membrane|Toll Like Receptor TLR1:TLR2 Cascade|Toll Like Receptor TLR6:TLR2 Cascade"	"Antiviral Signaling through Pattern Recognition Receptors|TLR -> AP-1 signaling|TLR1/2/6 -> NF-kB signaling|Toll-like Receptors Act through MYD88-TIRAP Signaling"	""	"diagnosis|efficacy|unspecified application"	"Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:17889651). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins (PubMed:10426996). Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6 (PubMed:11441107). Acts as a receptor for M.tuberculosis lipoproteins LprA, LprG, LpqH and PhoS1 (pstS1), some lipoproteins are dependent on other coreceptors (TLR1, CD14 and/or CD36).The lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712). Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (PubMed:16880211)."	""	"TRUE"
"3836-51_2"	"SL010528"	"UFM1"	"Ubiquitin-fold modifier 1"	"13"	"38349849"	"38363619"	"UFM1"	"51569"	"P61960"	""	""	""	""	""	""	""	"Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1 (PubMed:15071506, PubMed:20018847). This post-translational modification on lysine residues of proteins may play a crucial role in a number of cellular processes. TRIP4 ufmylation may for instance play a role in nuclear receptors-mediated transcription (PubMed:25219498). Other substrates may include DDRGK1 with which it may play a role in the cellular response to endoplasmic reticulum stress (Probable)."	""	"TRUE"
"3839-60_2"	"SL011629"	"AIP"	"AH receptor-interacting protein"	"11"	"67483041"	"67491103"	"AIP"	"9049"	"O00170"	""	""	""	""	""	""	""	"May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting."	""	"TRUE"
"3844-2_1"	"SL004823"	"Cyclophilin A"	"Peptidyl-prolyl cis-trans isomerase A"	"7"	"44796680"	"44824564"	"PPIA"	"5478"	"P62937"	"Prolactin Signaling Pathway"	""	""	"APOBEC3G mediated resistance to HIV-1 infection|Assembly Of The HIV Virion|Basigin interactions|Binding and entry of HIV virion|Budding and maturation of HIV virion|Early Phase of HIV Life Cycle|Integration of provirus|Minus-strand DNA synthesis|Platelet degranulation|Plus-strand DNA synthesis|Uncoating of the HIV Virion"	""	"N-methyl-4-Ile-cyclosporin"	""	"PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides."	""	"TRUE"
"3845-51_2"	"SL011530"	"DLRB1"	"Dynein light chain roadblock-type 1"	"20"	"34516409"	"34540958"	"DYNLRB1"	"83658"	"Q9NP97"	""	"TGF-beta receptor signaling"	""	"Intraflagellar transport"	""	""	""	"Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules."	"122|308|353"	"TRUE"
"3847-56_2"	"SL011532"	"ETHE1"	"Persulfide dioxygenase ETHE1, mitochondrial"	"19"	"43506719"	"43527244"	"ETHE1"	"23474"	"O95571"	""	""	""	"Sulfide oxidation to sulfate"	""	""	""	"Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus (PubMed:12398897)."	"274"	"TRUE"
"3848-14_2"	"SL003785"	"GAPDH, liver"	"Glyceraldehyde-3-phosphate dehydrogenase"	"12"	"6533927"	"6538374"	"GAPDH"	"2597"	"P04406"	"Alzheimers Disease|Glycolysis and Gluconeogenesis"	"Validated targets of C-MYC transcriptional activation"	"glycolysis"	"Gluconeogenesis|Glycolysis"	"Secretory Pathway: Golgi Transport"	""	"diagnosis|unspecified application"	"Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation."	""	"TRUE"
"3852-19_2"	"SL000449"	"HSP 40"	"DnaJ homolog subfamily B member 1"	"19"	"14514770"	"14529770"	"DNAJB1"	"3337"	"P25685"	"Epithelium TarBase|Leukocyte TarBase|Lymphocyte TarBase|Muscle cell TarBase|Squamous cell  TarBase"	""	""	"Attenuation phase|HSF1-dependent transactivation|Regulation of HSF1-mediated heat shock response"	""	""	""	"Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP."	""	"TRUE"
"3853-56_1"	"SL008102"	"MDHC"	"Malate dehydrogenase, cytoplasmic"	"2"	"63588609"	"63607197"	"MDH1"	"4190"	"P40925"	"Glycolysis and Gluconeogenesis|TCA Cycle"	""	""	"Gluconeogenesis"	""	""	""	"(S)-malate + NAD(+) = oxaloacetate + NADH."	""	"TRUE"
"3854-24_1"	"SL011631"	"NACA"	"Nascent polypeptide-associated complex subunit alpha"	"12"	"56712428"	"56731628"	"NACA"	"4666"	"Q13765"	""	"Integrin-linked kinase signaling"	""	""	""	""	""	"Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters."	""	"TRUE"
"3855-56_1"	"SL004919"	"Peroxiredoxin-1"	"Peroxiredoxin-1"	"1"	"45511036"	"45523047"	"PRDX1"	"5052"	"Q06830"	"Androgen receptor signaling pathway|Selenium Pathway"	"Coregulation of Androgen receptor activity"	""	"Detoxification of Reactive Oxygen Species|TP53 Regulates Metabolic Genes"	""	""	"diagnosis"	"Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity)."	""	"TRUE"
"3858-5_1"	"SL008063"	"PPAC"	"Low molecular weight phosphotyrosine protein phosphatase"	"2"	"264140"	"278283"	"ACP1"	"52"	"P24666"	""	"EPHA2 forward signaling"	""	""	""	""	""	"Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity."	"3|209|255|430"	"TRUE"
"3859-50_2"	"SL010973"	"PSA1"	"Proteasome subunit alpha type-1"	"11"	"14504874"	"14643635"	"PSMA1"	"5682"	"P25786"	"Proteasome Degradation"	""	""	"APC/C:Cdc20 mediated degradation of Securin|APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1|AUF1 (hnRNP D0) destabilizes mRNA|Activation of NF-kappaB in B cells|Antigen processing: Ubiquitination & Proteasome degradation|Asymmetric localization of PCP proteins|Autodegradation of Cdh1 by Cdh1:APC/C|Autodegradation of the E3 ubiquitin ligase COP1|CDK-mediated phosphorylation and removal of Cdc6|CDT1 association with the CDC6:ORC:origin complex|CLEC7A (Dectin-1) signaling|Cdc20:Phospho-APC/C mediated degradation of Cyclin A|Cross-presentation of soluble exogenous antigens (endosomes)|Dectin-1 mediated noncanonical NF-kB signaling|Degradation of GLI1 by the proteasome|Degradation of GLI2 by the proteasome|Degradation of beta-catenin by the destruction complex|ER-Phagosome pathway|GLI3 is processed to GLI3R by the proteasome|Hedgehog 'on' state|Hedgehog ligand biogenesis|Hh mutants that don't undergo autocatalytic processing are degraded by ERAD|Orc1 removal from chromatin|Regulation of activated PAK-2p34 by proteasome mediated degradation|Regulation of ornithine decarboxylase (ODC)|SCF(Skp2)-mediated degradation of p27/p21|SCF-beta-TrCP mediated degradation of Emi1|Separation of Sister Chromatids|Ubiquitin Mediated Degradation of Phosphorylated Cdc25A|Ubiquitin-dependent degradation of Cyclin D1|Vif-mediated degradation of APOBEC3G|Vpu mediated degradation of CD4|degradation of AXIN|degradation of DVL"	""	""	""	"The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Mediates the lipopolysaccharide-induced signal transduction in the macrophage proteasome (By similarity). Might be involved in the anti-inflammatory response of macrophages during the interaction with C.albicans heat-inactivated cells (By similarity)."	""	"TRUE"
"3860-7_2"	"SL005630"	"PSA6"	"Proteasome subunit alpha type-6"	"14"	"35278633"	"35317493"	"PSMA6"	"5687"	"P60900"	"Proteasome Degradation"	""	""	"APC/C:Cdc20 mediated degradation of Securin|APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1|AUF1 (hnRNP D0) destabilizes mRNA|Activation of NF-kappaB in B cells|Antigen processing: Ubiquitination & Proteasome degradation|Asymmetric localization of PCP proteins|Autodegradation of Cdh1 by Cdh1:APC/C|Autodegradation of the E3 ubiquitin ligase COP1|CDK-mediated phosphorylation and removal of Cdc6|CDT1 association with the CDC6:ORC:origin complex|CLEC7A (Dectin-1) signaling|Cdc20:Phospho-APC/C mediated degradation of Cyclin A|Cross-presentation of soluble exogenous antigens (endosomes)|Dectin-1 mediated noncanonical NF-kB signaling|Degradation of GLI1 by the proteasome|Degradation of GLI2 by the proteasome|Degradation of beta-catenin by the destruction complex|ER-Phagosome pathway|GLI3 is processed to GLI3R by the proteasome|Hedgehog 'on' state|Hedgehog ligand biogenesis|Hh mutants that don't undergo autocatalytic processing are degraded by ERAD|Orc1 removal from chromatin|Regulation of activated PAK-2p34 by proteasome mediated degradation|Regulation of ornithine decarboxylase (ODC)|SCF(Skp2)-mediated degradation of p27/p21|SCF-beta-TrCP mediated degradation of Emi1|Separation of Sister Chromatids|Ubiquitin Mediated Degradation of Phosphorylated Cdc25A|Ubiquitin-dependent degradation of Cyclin D1|Vif-mediated degradation of APOBEC3G|Vpu mediated degradation of CD4|degradation of AXIN|degradation of DVL"	""	""	""	"The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity."	""	"TRUE"
"3864-5_2"	"SL011528"	"RS7"	"40S ribosomal protein S7"	"2"	"3575205"	"3580919"	"RPS7"	"6201"	"P62081"	"Cytoplasmic Ribosomal Proteins"	""	""	"Eukaryotic Translation Termination|Formation of a pool of free 40S subunits|Formation of the ternary complex, and subsequently, the 43S complex|GTP hydrolysis and joining of the 60S ribosomal subunit|L13a-mediated translational silencing of Ceruloplasmin expression|Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)|Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)|Peptide chain elongation|Ribosomal scanning and start codon recognition|SRP-dependent cotranslational protein targeting to membrane|Translation initiation complex formation|Viral mRNA Translation"	""	""	""	"Required for rRNA maturation."	""	"TRUE"
"3865-53_1"	"SL006919"	"RSK-like protein kinase"	"Ribosomal protein S6 kinase alpha-5"	"14"	"90847862"	"91060636"	"RPS6KA5"	"9252"	"O75582"	"EGF/EGFR Signaling Pathway|Insulin Signaling|Serotonin HTR1 Group and FOS Pathway|Serotonin Receptor 4/6/7 and NR3C Signaling|p38 MAPK Signaling Pathway"	"ErbB1 downstream signaling|LPA4-mediated signaling events|Signaling mediated by p38-alpha and p38-beta|Trk receptor signaling mediated by the MAPK pathway"	""	"CD209 (DC-SIGN) signaling|CREB phosphorylation|ERK/MAPK targets|NCAM signaling for neurite out-growth|Recycling pathway of L1"	"ADRA1A -> IL6 production|CHRM1 -> IL2 production|CNR1/2 -> IL1B/2/4/6/10 production|CannabinoidR -> AP-1/EGR signaling|CholinergicRm -> CREB/ELK-SRF signaling|DopamineR2 -> AP-1/CREB/ELK-SRF signaling|EDNRA/B -> vascular motility|EGFR -> AP-1/CREB/ELK-SRF/MYC signaling|ERBB2/3 -> EP300/ETS/ETV/SP1 signaling|EndothelinRa -> AP-1/CREB signaling|EndothelinRb -> AP-1/CREB/ELK-SRF signaling|ErythropoietinR -> AP-1/CREB/MYC signaling|FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling|GRM1/5 -> CREB signaling|HGFR -> AP-1/CREB/MYC signaling|HTR1 -> IL6 production|HTR5 -> TNF production|HTR7 -> IL6 production|Histone Phosphorylation|ICAM1 -> AP-1/CREB/ELK-SRF signaling|NGFR -> AP-1/CEBPB/CREB/ELK-SRF/TP53 signaling|NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling|Nociception-related DRD2 expression targets|OpioidR -> CREB/ELK-SRF/STAT3 signaling|PTAFR -> AP-1/ATF1/CREB/ERK-SRF signaling|ProstaglandinFR -> ATF1/ELK-SRF/CREB signaling|ProstaglandinIR -> ATF1/ELK-SRF/CREB signaling|SerotoninR1 -> FOS signaling|SerotoninR4/6/7 -> NR3C signaling|Summarized nociception-related expression targets|T-cell receptor -> ATF/CREB signaling|TGFBR -> CREB/ELK-SRF signaling|TNFR -> CREB/ELK-SRF signaling|TNFRSF1A -> CREB/ELK-SRF signaling|ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling|ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling|VEGFR -> AP-1/CREB/MYC signaling|VEGFR -> ATF/CREB/ELK-SRF signaling|VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling|VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling"	""	""	"Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression. In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress. In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential. Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury."	""	"TRUE"
"3866-7_2"	"SL011529"	"SBDS"	"Ribosome maturation protein SBDS"	"7"	"66987677"	"66995601"	"SBDS"	"51119"	"Q9Y3A5"	""	""	""	""	""	""	""	"Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFTUD1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation."	""	"FALSE"
"3867-49_1"	"SL011630"	"SE6L2"	"Seizure 6-like protein 2"	"16"	"29871159"	"29899547"	"SEZ6L2"	"26470"	"Q6UXD5"	""	""	""	""	""	""	""	"May contribute to specialized endoplasmic reticulum functions in neurons."	""	"TRUE"
"3868-8_1"	"SL011533"	"SGTA"	"Small glutamine-rich tetratricopeptide repeat-containing protein alpha"	"19"	"2754714"	"2783371"	"SGTA"	"6449"	"O43765"	""	""	""	""	""	""	""	"Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity."	""	"TRUE"
"3872-2_1"	"SL005679"	"TCTP"	"Translationally-controlled tumor protein"	"13"	"45333471"	"45341370"	"TPT1"	"7178"	"P13693"	""	"PLK1 signaling events"	""	""	"Translation"	""	""	"Involved in calcium binding and microtubule stabilization."	""	"FALSE"
"3873-51_2"	"SL000588"	"TMA"	"Thyroid peroxidase"	"2"	"1374223"	"1543711"	"TPO"	"7173"	"P07202"	""	""	"thyroid hormone biosynthesis"	"Thyroxine biosynthesis"	""	"propylthiouracil|carbimazole|methimazole"	""	"Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4)."	""	"TRUE"
"3874-8_1"	"SL008157"	"UB2L3"	"Ubiquitin-conjugating enzyme E2 L3"	"22"	"21549447"	"21624034"	"UBE2L3"	"7332"	"P68036"	""	"Alpha-synuclein signaling|BARD1 signaling events"	"protein ubiquitination"	"Antigen processing: Ubiquitination & Proteasome degradation"	"TLR4 Signaling in Leukocytes"	""	""	"Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PARK2 and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis."	""	"TRUE"
"3875-62_1"	"SL011549"	"ARI3A"	"AT-rich interactive domain-containing protein 3A"	"19"	"925781"	"975934"	"ARID3A"	"1820"	"Q99856"	""	"Direct p53 effectors"	""	""	""	""	""	"Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation."	""	"TRUE"
"3876-15_2"	"SL008835"	"ASGR1"	"Asialoglycoprotein receptor 1"	"17"	"7173431"	"7179564"	"ASGR1"	"432"	"P07306"	"NA"	"NA"	"NA"	"NA"	"NA"	""	""	"Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface."	""	"TRUE"
"3877-67_2"	"SL004938"	"CaMKK alpha"	"Calcium/calmodulin-dependent protein kinase kinase 1"	"17"	"3860315"	"3894891"	"CAMKK1"	"84254"	"Q8N5S9"	"AMPK signaling"	""	""	"CREB phosphorylation through the activation of CaMKK"	"CRH -> synthesis of corticosteroids|EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG signaling|GABA(B)R -> postsynaptic inhibition|NPY1R -> CRH/POMC production|NeuropeptideYR -> ATF/CREB signaling|Summarized nociception-related expression targets|T-cell receptor -> CREBBP signaling|VasopressinR1 -> MEF/MYOD/NFATC/MYOG signaling|VasopressinR2 -> MEF/MYOD/NFATC/MYOG signaling"	""	""	"Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death."	""	"TRUE"
"3879-50_1"	"SL011232"	"CDC37"	"Hsp90 co-chaperone Cdc37"	"19"	"10391134"	"10420121"	"CDC37"	"11140"	"Q16543"	"TNF alpha Signaling Pathway"	"Integrin-linked kinase signaling|LKB1 signaling events"	""	"Constitutive Signaling by EGFRvIII|Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants|Signaling by ERBB2"	"Protein Folding"	""	""	"Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity."	""	"TRUE"
"3881-49_2"	"SL003753"	"DLC8"	"Dynein light chain 1, cytoplasmic"	"12"	"120469850"	"120498493"	"DYNLL1"	"8655"	"P63167"	""	""	""	"Activation of BIM and translocation to mitochondria|Anchoring of the basal body to the plasma membrane|Intraflagellar transport|Loss of Nlp from mitotic centrosomes|Loss of proteins required for interphase microtubule organization from the centrosome|MHC class II antigen presentation|Recruitment of mitotic centrosome proteins and complexes|Regulation of PLK1 Activity at G2/M Transition"	""	""	""	"Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures."	""	"TRUE"
"3882-10_1"	"SL005685"	"EF-1-beta"	"Elongation factor 1-beta"	"2"	"206159585"	"206162928"	"EEF1B2"	"1933"	"P24534"	"NA"	"NA"	"NA"	"NA"	"NA"	""	""	"EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP."	""	"TRUE"
"3884-5_1"	"SL005687"	"eIF-5A-1"	"Eukaryotic translation initiation factor 5A-1"	"17"	"7306999"	"7312463"	"EIF5A"	"1984"	"P63241"	"NA"	"NA"	"NA"	"NA"	"NA"	""	""	"mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts."	""	"TRUE"
"3886-72_1"	"SL009431"	"HINT1"	"Histidine triad nucleotide-binding protein 1"	"5"	"131159027"	"131171735"	"HINT1"	"3094"	"P49773"	"NA"	"NA"	"NA"	"NA"	"NA"	""	"prognosis"	"Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex."	""	"TRUE"
"3887-90_2"	"SL010927"	"IMB1"	"Importin subunit beta-1"	"17"	"47649476"	"47685505"	"KPNB1"	"3837"	"Q14974"	"SREBP signalling"	"Regulation of cytoplasmic and nuclear SMAD2/3 signaling|Role of Calcineurin-dependent NFAT signaling in lymphocytes|Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)|Signaling events mediated by TCPTP"	""	"Activation of DNA fragmentation factor|ISG15 antiviral mechanism|Nuclear import of Rev protein|Regulation of cholesterol biosynthesis by SREBP (SREBF)|Transport of Ribonucleoproteins into the Host Nucleus"	"Protein Nuclear Import and Export"	""	""	"Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports SNAI1 and PRKCI into the nucleus."	""	"TRUE"
"3888-8_1"	"SL009628"	"ING1"	"Inhibitor of growth protein 1"	"13"	"110712736"	"110723339"	"ING1"	"3621"	"Q9UK53"	"Senescence and Autophagy"	""	""	""	""	""	""	"Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene."	""	"TRUE"
"3889-64_2"	"SL006132"	"Lamin-B1"	"Lamin-B1"	"5"	"126776623"	"126837020"	"LMNB1"	"4001"	"P20700"	"FAS pathway and Stress induction of HSP regulation"	"Caspase Cascade in Apoptosis"	""	"Breakdown of the nuclear lamina|Clearance of Nuclear Envelope Membranes from Chromatin|Depolymerisation of the Nuclear Lamina|Formation of Senescence-Associated Heterochromatin Foci (SAHF)|Initiation of Nuclear Envelope Reformation|Meiotic synapsis"	"Cell Death Mediated by Cytotoxic Cells|Cleavage of Lamina in Apoptosis|Nuclear Envelope"	""	""	"Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin."	""	"TRUE"
"3890-8_2"	"SL000493"	"LDH-H 1"	"L-lactate dehydrogenase B chain"	"12"	"21635342"	"21757857"	"LDHB"	"3945"	"P07195"	"Glycolysis and Gluconeogenesis"	""	"pyruvate fermentation to lactate"	"Pyruvate metabolism"	""	""	"unspecified application"	"(S)-lactate + NAD(+) = pyruvate + NADH."	""	"TRUE"
"3891-56_1"	"SL009629"	"MBD4"	"Methyl-CpG-binding domain protein 4"	"3"	"129430944"	"129440179"	"MBD4"	"8930"	"O95243"	""	""	""	"Cleavage of the damaged pyrimidine|Displacement of DNA glycosylase by APEX1|Recognition and association of DNA glycosylase with site containing an affected pyrimidine"	""	""	""	"Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein."	""	"TRUE"
"3892-21_2"	"SL010328"	"MED-1"	"Mediator of RNA polymerase II transcription subunit 1"	"17"	"39404285"	"39451286"	"MED1"	"5469"	"Q15648"	"NA"	"NA"	"NA"	"NA"	"NA"	""	""	"Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781)."	"450"	"TRUE"
"3893-64_1"	"SL001905"	"Mesothelin"	"Mesothelin"	"16"	"643262"	"768865"	"MSLN"	"10232"	"Q13421"	""	""	""	""	""	"amatuximab"	"diagnosis|prognosis|unspecified application"	"Membrane-anchored forms may play a role in cellular adhesion."	""	"TRUE"
"3894-15_2"	"SL005629"	"NAGK"	"N-acetyl-D-glucosamine kinase"	"2"	"71064344"	"71079805"	"NAGK"	"55577"	"Q9UJ70"	""	""	"N-acetylneuraminate degradation"	""	""	""	""	"Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. Also has ManNAc kinase activity."	"134"	"TRUE"
"3896-5_2"	"SL004820"	"Phosphoglycerate mutase 1"	"Phosphoglycerate mutase 1"	"10"	"97426160"	"97433441"	"PGAM1"	"5223"	"P18669"	"Glycolysis and Gluconeogenesis"	""	""	"Gluconeogenesis|Glycolysis"	""	""	""	"Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity."	""	"TRUE"
"3897-61_1"	"SL011709"	"PLPP"	"Pyridoxal phosphate phosphatase"	"22"	"37658727"	"37666934"	"PDXP"	"57026"	"Q96GD0"	""	""	""	""	""	""	""	"Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho-tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP."	""	"TRUE"
"3898-5_2"	"SL007266"	"PSD7"	"26S proteasome non-ATPase regulatory subunit 7"	"16"	"74296775"	"74306288"	"PSMD7"	"5713"	"P51665"	"Proteasome Degradation"	""	""	"APC/C:Cdc20 mediated degradation of Securin|APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1|AUF1 (hnRNP D0) destabilizes mRNA|Activation of NF-kappaB in B cells|Antigen processing: Ubiquitination & Proteasome degradation|Asymmetric localization of PCP proteins|Autodegradation of Cdh1 by Cdh1:APC/C|Autodegradation of the E3 ubiquitin ligase COP1|CDK-mediated phosphorylation and removal of Cdc6|CDT1 association with the CDC6:ORC:origin complex|CLEC7A (Dectin-1) signaling|Cdc20:Phospho-APC/C mediated degradation of Cyclin A|Cross-presentation of soluble exogenous antigens (endosomes)|Dectin-1 mediated noncanonical NF-kB signaling|Degradation of GLI1 by the proteasome|Degradation of GLI2 by the proteasome|Degradation of beta-catenin by the destruction complex|ER-Phagosome pathway|GLI3 is processed to GLI3R by the proteasome|Hedgehog 'on' state|Hedgehog ligand biogenesis|Hh mutants that don't undergo autocatalytic processing are degraded by ERAD|Orc1 removal from chromatin|Regulation of activated PAK-2p34 by proteasome mediated degradation|Regulation of ornithine decarboxylase (ODC)|SCF(Skp2)-mediated degradation of p27/p21|SCF-beta-TrCP mediated degradation of Emi1|Separation of Sister Chromatids|Ubiquitin Mediated Degradation of Phosphorylated Cdc25A|Ubiquitin-dependent degradation of Cyclin D1|Vif-mediated degradation of APOBEC3G|Vpu mediated degradation of CD4|degradation of AXIN|degradation of DVL"	""	""	""	"Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins."	""	"TRUE"
"3902-21_2"	"SL008808"	"SKP1"	"S-phase kinase-associated protein 1"	"5"	"134148935"	"134177038"	"SKP1"	"6500"	"P63208"	"Notch Signaling Pathway|TGF beta Signaling Pathway|TNF alpha Signaling Pathway"	"Degradation of beta catenin|Notch signaling pathway|Regulation of nuclear beta catenin signaling and target gene transcription"	"protein ubiquitination"	"Activation of NF-kappaB in B cells|Antigen processing: Ubiquitination & Proteasome degradation|CLEC7A (Dectin-1) signaling|Circadian Clock|Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants|Constitutive Signaling by NOTCH1 PEST Domain Mutants|Cyclin D associated events in G1|Dectin-1 mediated noncanonical NF-kB signaling|Degradation of GLI1 by the proteasome|Degradation of GLI2 by the proteasome|Degradation of beta-catenin by the destruction complex|GLI3 is processed to GLI3R by the proteasome|Interleukin-1 signaling|Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling|NOTCH1 Intracellular Domain Regulates Transcription|Prolactin receptor signaling|Regulation of PLK1 Activity at G2/M Transition|SCF(Skp2)-mediated degradation of p27/p21|SCF-beta-TrCP mediated degradation of Emi1|Vpu mediated degradation of CD4"	""	""	""	"Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and probably NFKB2 (PubMed:25704143). SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2."	""	"TRUE"
"3903-49_2"	"SL005372"	"Sorting nexin 4"	"Sorting nexin-4"	"3"	"125446644"	"125520197"	"SNX4"	"8723"	"O95219"	""	""	""	""	"Endosomal Recycling|Golgi to Endosome Transport"	""	""	"May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation."	""	"TRUE"
"3905-62_1"	"SL008143"	"UBE2N"	"Ubiquitin-conjugating enzyme E2 N"	"12"	"93405673"	"93442262"	"UBE2N"	"7334"	"P61088"	"IL-1 signaling pathway"	"ATM pathway|IL1-mediated signaling events"	"protein ubiquitination"	"Antigen processing: Ubiquitination & Proteasome degradation|CLEC7A (Dectin-1) signaling|Downstream TCR signaling|FCERI mediated NF-kB activation|IKK complex recruitment mediated by RIP1|IRAK1 recruits IKK complex|IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation|ISG15 antiviral mechanism|Interleukin-1 signaling|NOD1/2 Signaling Pathway|TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling"	"Double Strand DNA Homologous Repair"	""	""	"The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes."	""	"FALSE"
"4122-12_2"	"SL004119"	"discoidin domain receptor 1"	"Epithelial discoidin domain-containing receptor 1"	"6"	"30870550"	"30944801"	"DDR1"	"780"	"Q08345"	""	""	""	"Non-integrin membrane-ECM interactions"	"DDR1 -> NF-kB signaling"	"nilotinib"	"diagnosis"	"Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11."	""	"TRUE"
"4123-60_2"	"SL003171"	"FGF-4"	"Fibroblast growth factor 4"	"11"	"69771016"	"69775403"	"FGF4"	"2249"	"P08620"	"MAPK signaling pathway|Regulation of Actin Cytoskeleton"	"FGF signaling pathway|Regulation of nuclear beta catenin signaling and target gene transcription"	""	"Activated point mutants of FGFR2|Constitutive Signaling by Aberrant PI3K in Cancer|FGFR1c ligand binding and activation|FGFR2c ligand binding and activation|FGFR3 mutant receptor activation|FGFR3c ligand binding and activation|FGFR4 ligand binding and activation|FRS-mediated FGFR1 signaling|FRS-mediated FGFR2 signaling|FRS-mediated FGFR3 signaling|FRS2-mediated FGFR4 signaling|Negative regulation of FGFR1 signaling|Negative regulation of FGFR2 signaling|Negative regulation of FGFR3 signaling|Negative regulation of FGFR4 signaling|PI-3K cascade:FGFR1|PI-3K cascade:FGFR2|PI-3K cascade:FGFR3|PI-3K cascade:FGFR4|PI3K Cascade|PIP3 activates AKT signaling|Phospholipase C-mediated cascade, FGFR2|Phospholipase C-mediated cascade, FGFR3|Phospholipase C-mediated cascade, FGFR4|Phospholipase C-mediated cascade: FGFR1|SHC-mediated cascade:FGFR1|SHC-mediated cascade:FGFR2|SHC-mediated cascade:FGFR3|SHC-mediated cascade:FGFR4|Signaling by FGFR1 mutants|Signaling by FGFR2 mutants|Signaling by FGFR3 mutants|Signaling by FGFR4 mutants|Signaling by activated point mutants of FGFR1|Signaling by activated point mutants of FGFR3"	"FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling|FGFR -> RUNX2 signaling|FGFR1 -> STAT signaling|FGFR3 -> STAT signaling"	""	""	"Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis."	""	"TRUE"
"4124-24_2"	"SL000451"	"HSP 70"	"Heat shock 70 kDa protein 1A/1B"	"6"	"31797650"	"31897281"	"HSPA1A"	"3303"	"P08107"	""	""	""	""	""	""	""	"In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223)."	""	"TRUE"
"4125-52_2"	"SL003680"	"sRAGE"	"Advanced glycosylation end product-specific receptor, soluble"	"6"	"32129439"	"32260750"	"AGER"	"177"	"Q15109"	""	"amb2 Integrin signaling"	""	"Advanced glycosylation endproduct receptor signaling|DEx/H-box helicases activate type I IFN and inflammatory cytokines production|RIP-mediated NFkB activation via ZBP1|TAK1 activates NFkB by phosphorylation and activation of IKKs complex|TRAF6 mediated NF-kB activation"	"AGER ->  CREB/SP1 signaling|AGER ->  NF-kB signaling"	""	"diagnosis|efficacy|unspecified application"	"Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides."	""	"TRUE"
"4126-22_1"	"SL004511"	"BPI"	"Bactericidal permeability-increasing protein"	"20"	"38260149"	"38337505"	"BPI"	"671"	"P17213"	""	""	""	""	""	""	""	"The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa."	""	"TRUE"
"4127-75_1"	"SL000322"	"C6"	"Complement component C6"	"5"	"41142234"	"41261438"	"C6"	"729"	"P13671"	"Complement Activation, Classical Pathway|Complement and Coagulation Cascades"	""	""	"Regulation of Complement cascade|Terminal pathway of complement"	"Alternative Complement Pathway|Classical Complement Pathway|Lectin-Induced Complement Pathway"	""	""	"Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells."	""	"TRUE"
"4128-27_2"	"SL003104"	"Eotaxin-2"	"C-C motif chemokine 24"	"7"	"75811665"	"75823356"	"CCL24"	"6369"	"O00175"	""	""	""	""	""	""	""	"Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. Binds to CCR3."	""	"TRUE"
"4129-72_1"	"SL000414"	"Factor B"	"Complement factor B"	"6"	"31927837"	"32028527"	"CFB"	"629"	"P00751"	""	""	""	"Activation of C3 and C5|Alternative complement activation|Regulation of Complement cascade"	"Alternative Complement Pathway"	""	""	"Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes."	"142|200"	"TRUE"
"4130-71_1"	"SL004340"	"FGF-6"	"Fibroblast growth factor 6"	"12"	"4428155"	"4445614"	"FGF6"	"2251"	"P10767"	"Regulation of Actin Cytoskeleton"	"FGF signaling pathway|Syndecan-4-mediated signaling events"	""	"Activated point mutants of FGFR2|Constitutive Signaling by Aberrant PI3K in Cancer|FGFR1c ligand binding and activation|FGFR2c ligand binding and activation|FGFR4 ligand binding and activation|FRS-mediated FGFR1 signaling|FRS-mediated FGFR2 signaling|FRS2-mediated FGFR4 signaling|Negative regulation of FGFR1 signaling|Negative regulation of FGFR2 signaling|Negative regulation of FGFR4 signaling|PI-3K cascade:FGFR1|PI-3K cascade:FGFR2|PI-3K cascade:FGFR4|PI3K Cascade|PIP3 activates AKT signaling|Phospholipase C-mediated cascade, FGFR2|Phospholipase C-mediated cascade, FGFR4|Phospholipase C-mediated cascade: FGFR1|SHC-mediated cascade:FGFR1|SHC-mediated cascade:FGFR2|SHC-mediated cascade:FGFR4|Signaling by FGFR1 mutants|Signaling by FGFR2 mutants|Signaling by FGFR4 mutants|Signaling by activated point mutants of FGFR1"	"FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling|FGFR -> RUNX2 signaling|FGFR1 -> STAT signaling"	""	""	"Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration."	""	"TRUE"
"4131-72_2"	"SL000426"	"Fibronectin"	"Fibronectin"	"2"	"215360440"	"215436172"	"FN1"	"2335"	"P02751"	"Focal Adhesion|Inflammatory Response Pathway|Regulation of Actin Cytoskeleton|Senescence and Autophagy"	"Alpha4 beta1 integrin signaling events|Alpha9 beta1 integrin signaling events|Angiopoietin receptor Tie2-mediated signaling|Beta1 integrin cell surface interactions|Beta3 integrin cell surface interactions|Beta5 beta6 beta7 and beta8 integrin cell surface interactions|Integrins in angiogenesis|Syndecan-2-mediated signaling events|Syndecan-4-mediated signaling events|Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling|VEGFR3 signaling in lymphatic endothelium"	""	"Cell surface interactions at the vascular wall|Degradation of the extracellular matrix|ECM proteoglycans|Extracellular matrix organization|Fibronectin matrix formation|GRB2:SOS provides linkage to MAPK signaling for Integrins|Integrin alphaIIb beta3 signaling|Integrin cell surface interactions|Molecules associated with elastic fibres|Non-integrin membrane-ECM interactions|Platelet degranulation|Syndecan interactions|p130Cas linkage to MAPK signaling for integrins"	"Extracellular Matrix Turnover|FibronectinR -> AP-1/ELK-SRF/SREBF signaling|FibronectinR -> CTNNB signaling|FibronectinR -> ICAP-1A/MYC signaling|FibronectinR -> NF-kB signaling|Focal Junction Assembly|Natural Killer Cell Activation through Integrins and non-ITAM-Containing Receptors"	"ocriplasmin"	"diagnosis|efficacy|prognosis|unspecified application"	"Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts."	"77"	"TRUE"
"4132-27_2"	"SL000674"	"FST"	"Follistatin"	"5"	"53480409"	"53487134"	"FST"	"10468"	"P19883"	"TGF Beta Signaling Pathway"	"BMP receptor signaling"	""	"Antagonism of Activin by Follistatin"	""	""	""	"Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH)."	""	"TRUE"
"4133-54_2"	"SL004068"	"Granzyme B"	"Granzyme B"	"14"	"24630954"	"24634267"	"GZMB"	"3002"	"P10144"	"Apoptosis"	"Caspase Cascade in Apoptosis|Downstream signaling in naïve CD8+ T cells|IL12-mediated signaling events"	""	"Activation, myristolyation of BID and translocation to mitochondria|NOTCH2 intracellular domain regulates transcription"	"CD8+ T-cell Activation|Cell Death Mediated by Cytotoxic Cells|Natural Killer Cell Activation"	""	""	"This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis."	""	"TRUE"
"4134-4_2"	"SL000138"	"HB-EGF"	"Heparin-binding EGF-like growth factor"	"5"	"140332843"	"140346631"	"HBEGF"	"1839"	"Q99075"	"ErbB signaling pathway|Hypertrophy Model"	"ErbB receptor signaling network|ErbB4 signaling events|LPA receptor mediated events|Plasma membrane estrogen receptor signaling"	""	"Constitutive Signaling by Aberrant PI3K in Cancer|EGFR Transactivation by Gastrin|GRB2 events in ERBB2 signaling|Nuclear signaling by ERBB4|PI3K events in ERBB2 signaling|PI3K events in ERBB4 signaling|PIP3 activates AKT signaling|SHC1 events in ERBB2 signaling|SHC1 events in ERBB4 signaling|Signaling by ERBB2|Signaling by ERBB4|Uptake and function of diphtheria toxin"	"EGFR -> AP-1/ATF2 signaling|EGFR -> AP-1/CREB/ELK-SRF/MYC signaling|EGFR -> CTNND signaling|EGFR -> NCOR2 signaling|EGFR -> SMAD1 signaling|EGFR -> ZNF259 signaling|EGFR/ERBB -> STAT signaling|EGFR/ERBB2 -> CTNNB signaling|EGFR/ERBB2 -> HIF1A signaling|EGFR/ERBB2 -> TP53 signaling|EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG signaling|ERBB2/3 -> EP300/ETS/ETV/SP1 signaling"	""	"diagnosis|unspecified application"	"Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor."	""	"TRUE"
"4135-84_2"	"SL000461"	"IgE"	"Immunoglobulin E"	"14"	"105598666"	"105602504"	"IGHE|IGK@|IGL@"	"3497|50802|3535"	"P01854"	""	"Fc-epsilon receptor I signaling in mast cells|IL4-mediated signaling events"	""	"FCERI mediated Ca+2 mobilization|FCERI mediated MAPK activation|FCERI mediated NF-kB activation|Fc epsilon receptor (FCERI) signaling|Role of LAT2/NTAL/LAB on calcium mobilization"	""	"omalizumab"	""	"The following alleles of IGHE are known: IGHE*01 and IGHE*02. The sequence shown is that of allele 02."	""	"TRUE"
"4136-40_2"	"SL004353"	"IL-17D"	"Interleukin-17D"	"13"	"20702127"	"20723098"	"IL17D"	"53342"	"Q8TAD2"	""	""	""	""	""	""	""	"Induces expression of IL-6, IL-8, and GM-CSF from endothelial cells."	""	"TRUE"
"4137-57_2"	"SL004351"	"IL-17E"	"Interleukin-25"	"14"	"23372809"	"23376403"	"IL25"	"64806"	"Q9H293"	""	""	""	""	""	""	""	"Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses."	"65|397"	"TRUE"
"4138-25_2"	"SL004346"	"IL-20"	"Interleukin-20"	"1"	"206865354"	"206869223"	"IL20"	"50604"	"Q9NYY1"	""	""	""	""	""	""	""	"Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3."	""	"TRUE"
"4139-71_2"	"SL001943"	"IL-6 sRa"	"Interleukin-6 receptor subunit alpha"	"1"	"154405193"	"154469450"	"IL6R"	"3570"	"P08887"	"IL-6 signaling pathway|SIDS Susceptibility Pathways|Senescence and Autophagy"	"IL6-mediated signaling events|SHP2 signaling"	""	"ERK1 activation|ERK2 activation|Interleukin-6 signaling"	"IL6R -> CEBP/ELK-SRF signaling|IL6R -> STAT signaling|Nociception-related IL6 expression targets|Th17 Cell Differentiation"	"tocilizumab"	"efficacy"	"Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis."	"2|273|296"	"TRUE"
"4140-3_2"	"SL000483"	"IL-7"	"Interleukin-7"	"8"	"78675743"	"78805523"	"IL7"	"3574"	"P13232"	"IL-7 signaling pathway"	""	""	"Interleukin-7 signaling"	"IL7R -> FOXO/NF-kB signaling|IL7R -> STAT signaling|Model of T-cell Maturation|T-cell-Dependent B-cell Activation|V(D)J Recombination Activation"	""	"efficacy|unspecified application"	"Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation."	""	"TRUE"
"4141-79_1"	"SL003183"	"IP-10"	"C-X-C motif chemokine 10"	"4"	"76021117"	"76023497"	"CXCL10"	"3627"	"P02778"	"Regulation of toll-like receptor signaling pathway|Toll-like receptor signaling pathway|Type II interferon signaling (IFNG)"	"CXCR3-mediated signaling events"	""	"Chemokine receptors bind chemokines|G alpha (i) signalling events"	"Nociception-related CCR1 expression targets|Summarized nociception-related expression targets"	"MDX-1100"	"diagnosis|efficacy|unspecified application"	"Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3."	"187"	"TRUE"
"4143-74_2"	"SL003186"	"Lymphotactin"	"Lymphotactin"	"1"	"168576473"	"168582077"	"XCL1"	"6375"	"P47992"	""	""	""	"Chemokine receptors bind chemokines|G alpha (q) signalling events"	""	""	"unspecified application"	"Chemotactic activity for lymphocytes but not for monocytes or neutrophils."	""	"TRUE"
"4144-13_1"	"SL000517"	"MCP-4"	"C-C motif chemokine 13"	"17"	"34356452"	"34358610"	"CCL13"	"6357"	"Q99616"	""	""	""	""	"CCR1 -> STAT signaling|CCR2/5 -> STAT signaling|CCR5 -> TP53 signaling|Nociception-related CCR1 expression targets|Summarized nociception-related expression targets"	""	""	"Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens."	""	"TRUE"
"4145-58_2"	"SL004359"	"Neurotrophin-3"	"Neurotrophin-3"	"12"	"5432112"	"5521536"	"NTF3"	"4908"	"P20783"	""	"Neurotrophic factor-mediated Trk receptor signaling|SHP2 signaling|Trk receptor signaling mediated by the MAPK pathway|p75(NTR)-mediated signaling"	""	""	"GFs/TNF -> ion channels|NGFR -> AP-1/CEBPB/CREB/ELK-SRF/TP53 signaling|NGFR -> MEF signaling|NGFR -> NF-kB signaling|NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling|NTRK -> FOXO/MYCN signaling|NTRK1/2/3 -> acetylcholine production"	""	"diagnosis"	"Seems to promote the survival of visceral and proprioceptive sensory neurons."	""	"TRUE"
"4146-58_2"	"SL004360"	"Neurotrophin-5"	"Neurotrophin-4"	"19"	"49055793"	"49065076"	"NTF4"	"4909"	"P34130"	"MAPK signaling pathway"	"Neurotrophic factor-mediated Trk receptor signaling|SHP2 signaling|p75(NTR)-mediated signaling"	""	""	"NGFR -> AP-1/CEBPB/CREB/ELK-SRF/TP53 signaling|NGFR -> MEF signaling|NGFR -> NF-kB signaling|NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling|NTRK -> FOXO/MYCN signaling|NTRK1/2/3 -> acetylcholine production"	""	""	"Target-derived survival factor for peripheral sensory sympathetic neurons."	""	"TRUE"
"4148-49_2"	"SL002755"	"PAPP-A"	"Pappalysin-1"	"9"	"116153804"	"116402322"	"PAPPA"	"5069"	"Q13219"	""	""	""	"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"	""	""	"diagnosis"	"Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF."	""	"TRUE"
"4149-8_2"	"SL000537"	"PDGF-BB"	"Platelet-derived growth factor subunit B"	"22"	"39223359"	"39244751"	"PDGFB"	"5155"	"P01127"	"Angiogenesis|Focal Adhesion|MAPK signaling pathway|Osteoblast Signaling|Osteoclast Signaling|Regulation of Actin Cytoskeleton"	"Beta3 integrin cell surface interactions|Nectin adhesion pathway|PDGF receptor signaling network|PDGFR-beta signaling pathway|S1P1 pathway|S1P3 pathway|SHP2 signaling|Signaling events mediated by PTP1B|Signaling events mediated by TCPTP"	""	"Constitutive Signaling by Aberrant PI3K in Cancer|Downstream signal transduction|Non-integrin membrane-ECM interactions|PIP3 activates AKT signaling|Platelet degranulation|Signaling by PDGF"	"PDGFR -> AP-1/MYC signaling|PDGFR -> FOXO3A signaling|PDGFR -> STAT signaling"	""	"disease progression"	"Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin (PubMed:26599395). Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity)."	""	"TRUE"
"4150-75_2"	"SL000540"	"Plasmin"	"Plasmin"	"6"	"160702238"	"160753315"	"PLG"	"5340"	"P00747"	"Blood Clotting Cascade|Complement and Coagulation Cascades|Folate Metabolism|Selenium Pathway|Vitamin B12 Metabolism"	"Angiopoietin receptor Tie2-mediated signaling|Syndecan-4-mediated signaling events|Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling|amb2 Integrin signaling|p75(NTR)-mediated signaling"	""	"Activation of Matrix Metalloproteinases|Degradation of the extracellular matrix|Dissolution of Fibrin Clot|Platelet degranulation|Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)|Signaling by PDGF"	"Coagulation Cascade|ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling|ThrombinR -> NF-kB signaling|ThrombinR -> STAT1 signaling"	"tenecteplase|PLAT|tranexamic acid|aprotinin|6-aminocaproic acid|reteplase"	"diagnosis"	"Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells."	""	"TRUE"
"4151-6_2"	"SL000541"	"Plasminogen"	"Plasminogen"	"6"	"160702238"	"160753315"	"PLG"	"5340"	"P00747"	"Blood Clotting Cascade|Complement and Coagulation Cascades|Folate Metabolism|Selenium Pathway|Vitamin B12 Metabolism"	"Angiopoietin receptor Tie2-mediated signaling|Syndecan-4-mediated signaling events|Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling|amb2 Integrin signaling|p75(NTR)-mediated signaling"	""	"Activation of Matrix Metalloproteinases|Degradation of the extracellular matrix|Dissolution of Fibrin Clot|Platelet degranulation|Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)|Signaling by PDGF"	"Coagulation Cascade|ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling|ThrombinR -> NF-kB signaling|ThrombinR -> STAT1 signaling"	"tenecteplase|PLAT|tranexamic acid|aprotinin|6-aminocaproic acid|reteplase"	"diagnosis"	"Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells."	"291|345|378"	"TRUE"
"4152-58_2"	"SL000545"	"Prekallikrein"	"Plasma kallikrein"	"4"	"186208979"	"186258471"	"KLKB1"	"3818"	"P03952"	""	""	""	"Activation of Matrix Metalloproteinases|Intrinsic Pathway of Fibrin Clot Formation"	"Coagulation Cascade"	"aprotinin|ecallantide"	""	"The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin."	"96|138"	"TRUE"
"4153-11_2"	"SL018548"	"alpha-1-antichymotrypsin complex"	"alpha-1-antichymotrypsin complex"	"14"	"94592058"	"94624646"	"SERPINA3"	"NA"	"P01011"	"Folate Metabolism|Selenium Pathway|Vitamin B12 Metabolism"	""	""	""	""	""	"unspecified application"	"Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2."	"270"	"TRUE"
"4154-57_2"	"SL000560"	"P-Selectin"	"P-Selectin"	"1"	"169588849"	"169630193"	"SELP"	"6403"	"P16109"	""	"IL4-mediated signaling events|amb2 Integrin signaling"	""	"Cell surface interactions at the vascular wall|Platelet degranulation"	"Leukocyte Adhesion to Endothelial Cell"	""	"efficacy|safety|unspecified application"	"Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1."	"28|158"	"TRUE"
"4155-3_2"	"SL003198"	"Tenascin"	"Tenascin"	"9"	"115019578"	"115118257"	"TNC"	"3371"	"P24821"	"Focal Adhesion"	"Alpha9 beta1 integrin signaling events|Beta1 integrin cell surface interactions|Beta3 integrin cell surface interactions|Syndecan-4-mediated signaling events"	""	"ECM proteoglycans|Integrin cell surface interactions|Syndecan interactions"	""	""	"diagnosis|response to therapy"	"Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6."	"47"	"TRUE"
"4156-74_1"	"SL000088"	"TGF-b2"	"Transforming growth factor beta-2"	"1"	"218346235"	"218444619"	"TGFB2"	"7042"	"P61812"	"Endochondral Ossification|MAPK signaling pathway|p38 MAPK Signaling Pathway"	"ATF-2 transcription factor network|Glypican 1 network|Regulation of retinoblastoma protein|Signaling events mediated by the Hedgehog family|TGF-beta receptor signaling"	""	"ECM proteoglycans|Molecules associated with elastic fibres|Platelet degranulation"	"Cell Cycle|TGFBR -> AP-1 signaling|TGFBR -> ATF/GADD/MAX/TP53 signaling|TGFBR -> CREB/ELK-SRF signaling|TGFBR -> MEF/MYOD/MYOG signaling|TGFBR/BMPR -> SMAD2/3 signaling"	"trabedersen"	"efficacy|unspecified application"	"TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth."	""	"TRUE"
"4157-2_1"	"SL000586"	"Thrombin"	"Thrombin"	"11"	"46719180"	"46739506"	"F2"	"2147"	"P00734"	"Blood Clotting Cascade|Complement and Coagulation Cascades|Folate Metabolism|Regulation of Actin Cytoskeleton|Selenium Pathway|Vitamin B12 Metabolism|angiogenesis overview"	"Angiopoietin receptor Tie2-mediated signaling|FOXA2 and FOXA3 transcription factor networks|PAR1-mediated thrombin signaling events|PAR4-mediated thrombin signaling events|Syndecan-4-mediated signaling events|Thrombin/protease-activated receptor (PAR) pathway"	""	"Cell surface interactions at the vascular wall|Common Pathway of Fibrin Clot Formation|G alpha (q) signalling events|Gamma-carboxylation of protein precursors|Intrinsic Pathway of Fibrin Clot Formation|Peptide ligand-binding receptors|Platelet Aggregation (Plug Formation)|Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)|Removal of aminoterminal propeptides from gamma-carboxylated proteins|Thrombin signalling through proteinase activated receptors (PARs)|Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus"	"Coagulation Cascade|ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling|ThrombinR -> NF-kB signaling|ThrombinR -> STAT1 signaling|Vitamin K metabolism"	"enoxaparin|desirudin|dabigatran etexilate|Fibrinogen|ximelagatran|antithrombin alfa|aspirin/dabigatran etexilate|dabigatran|argatroban|bivalirudin|lepirudin"	"diagnosis|unspecified application"	"Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing."	""	"TRUE"
"4158-54_2"	"SL000613"	"uPA"	"Urokinase-type plasminogen activator"	"10"	"73909177"	"73917497"	"PLAU"	"5328"	"P00749"	"Blood Clotting Cascade|Complement and Coagulation Cascades|DNA damage response (only ATM dependent)|Endochondral Ossification|Osteopontin Signaling|Wnt Signaling Pathway|Wnt Signaling Pathway and Pluripotency"	"AP-1 transcription factor network|ATF-2 transcription factor network|Beta1 integrin cell surface interactions|Beta2 integrin cell surface interactions|Beta3 integrin cell surface interactions|Beta5 beta6 beta7 and beta8 integrin cell surface interactions|E2F transcription factor network|FGF signaling pathway|Osteopontin-mediated events|Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling|Validated transcriptional targets of AP1 family members Fra1 and Fra2|amb2 Integrin signaling"	""	"Dissolution of Fibrin Clot"	"Nociception-related IL1B expression targets|UrokinaseR -> ELK-SRF signaling|UrokinaseR -> STAT signaling"	""	"disease progression|efficacy|prognosis"	"Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin."	""	"TRUE"
"4159-130_1"	"SL000415"	"Factor H"	"Complement factor H"	"1"	"196651878"	"196747504"	"CFH"	"3075"	"P08603"	""	""	""	"Regulation of Complement cascade"	"Alternative Complement Pathway"	""	"unspecified application"	"Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b)NBB complex (C5 convertase) in the alternative complement pathway."	"111|326"	"TRUE"
"4160-49_1"	"SL000124"	"MMP-2"	"72 kDa type IV collagenase"	"16"	"55389700"	"55506691"	"MMP2"	"4313"	"P08253"	"Matrix Metalloproteinases|angiogenesis overview"	"ATF-2 transcription factor network|Angiopoietin receptor Tie2-mediated signaling|Direct p53 effectors|FOXM1 transcription factor network|LPA receptor mediated events|Osteopontin-mediated events|Plasma membrane estrogen receptor signaling|Regulation of nuclear beta catenin signaling and target gene transcription|Syndecan-2-mediated signaling events|Validated transcriptional targets of AP1 family members Fra1 and Fra2|amb2 Integrin signaling"	""	"Activation of Matrix Metalloproteinases|Collagen degradation|Degradation of the extracellular matrix|EPH-ephrin mediated repulsion of cells|Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"	"Extracellular Matrix Turnover|Nociception-related CCR1 expression targets|Summarized nociception-related expression targets"	"marimastat"	"diagnosis|disease progression|efficacy|prognosis|response to therapy|unspecified application"	"Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14."	""	"TRUE"
"4162-54_2"	"SL000601"	"Transferrin"	"Serotransferrin"	"3"	"133745956"	"133779006"	"TF"	"7018"	"P02787"	"iron metabolism in placenta"	"EPHB forward signaling|HIF-1-alpha transcription factor network"	""	"Iron uptake and transport|Platelet degranulation|Transferrin endocytosis and recycling"	"Endosomal Recycling|Transcytosis"	""	"efficacy|prognosis"	"Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation."	""	"TRUE"
"4163-5_2"	"SL002093"	"Histone H2A.z"	"Histone H2A.z"	"4"	"99948086"	"99950388"	"H2AFZ"	"3015"	"P0C0S5"	"Proteasome Degradation"	"C-MYB transcription factor network"	""	"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3|Amyloids|Condensation of Prophase Chromosomes|DNA Damage/Telomere Stress Induced Senescence|DNA methylation|Deposition of new CENPA-containing nucleosomes at the centromere|Meiotic recombination|Meiotic synapsis|NoRC negatively regulates rRNA expression|Oxidative Stress Induced Senescence|PRC2 methylates histones and DNA|Packaging Of Telomere Ends|RMTs methylate histone arginines|RNA Polymerase I Chain Elongation|RNA Polymerase I Promoter Opening|SIRT1 negatively regulates rRNA Expression|Senescence-Associated Secretory Phenotype (SASP)|Transcriptional regulation by small RNAs|formation of the beta-catenin:TCF transactivating complex"	"SRCAP Chromatin Remodeling"	""	""	"Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division."	""	"TRUE"
"4165-2_1"	"SL000587"	"Thyroglobulin"	"Thyroglobulin"	"8"	"132866958"	"133134903"	"TG"	"7038"	"P01266"	""	""	""	""	""	""	"diagnosis|unspecified application"	"Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3)."	""	"TRUE"
"4179-57_3"	"SL017611"	"14-3-3"	"14-3-3 protein family"	"1|17|2|20|22|7|8"	"26863138|1247054|9583972|44885676|31944461|76326794|100916525"	"26864457|1400378|9631014|44908532|31957603|76359031|100953388"	"YWHAB|YWHAE|YWHAG|YWHAH|YWHAQ|YWHAZ|SFN"	"7529|7531|7532|7533|10971|7534|2810"	"P31946|P62258|P61981|Q04917|P27348|P63104|P31947"	"Calcium Regulation in the Cardiac Cell|Cell cycle|Epithelium TarBase|IL-3 Signaling Pathway|Leukocyte TarBase|Lymphocyte TarBase|Muscle cell TarBase|Myometrial Relaxation and Contraction Pathways|Squamous cell  TarBase"	"Class I PI3K signaling events mediated by Akt|ErbB1 downstream signaling|FoxO family signaling|Insulin-mediated glucose transport|LKB1 signaling events|PDGFR-beta signaling pathway|Regulation of nuclear beta catenin signaling and target gene transcription|Role of Calcineurin-dependent NFAT signaling in lymphocytes|Trk receptor signaling mediated by PI3K and PLC-gamma|Validated transcriptional targets of TAp63 isoforms|a6b1 and a6b4 Integrin signaling|mTOR signaling pathway|p38 signaling mediated by MAPKAP kinases"	""	"Activation of BAD and translocation to mitochondria|Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex|RHO GTPases activate PKNs|TP53 Regulates Metabolic Genes|Translocation of GLUT4 to the plasma membrane"	""	""	"prognosis"	"Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2.|Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.|Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.|Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.|Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.|Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.|Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53."	""	"FALSE"
"4184-43_3"	"SL008378"	"4EBP2"	"Eukaryotic translation initiation factor 4E-binding protein 2"	"10"	"70404379"	"70428618"	"EIF4EBP2"	"1979"	"Q13542"	""	""	""	""	""	""	""	"Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (By similarity). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity)."	""	"TRUE"
"4187-49_2"	"SL000247"	"6-Phosphogluconate dehydrogenase"	"6-phosphogluconate dehydrogenase, decarboxylating"	"1"	"10398592"	"10420144"	"PGD"	"5226"	"P52209"	"Pentose Phosphate Pathway"	""	"pentose phosphate pathway"	"Pentose phosphate pathway (hexose monophosphate shunt)"	""	""	""	"Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH."	""	"FALSE"
"4188-1_2"	"SL003658"	"Aflatoxin B1 aldehyde reductase"	"Aflatoxin B1 aldehyde reductase member 2"	"1"	"19303965"	"19312146"	"AKR7A2"	"8574"	"O43488"	"Aflatoxin B1 metabolism|metapathway biotransformation"	""	""	"Aflatoxin activation and detoxification"	""	""	"diagnosis"	"Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen."	""	"TRUE"
"4192-10_2"	"SL008039"	"AK1A1"	"Alcohol dehydrogenase [NADP(+)]"	"1"	"45550543"	"45570049"	"AKR1A1"	"10327"	"P14550"	"Benzo(a)pyrene metabolism|metapathway biotransformation"	""	""	""	""	""	""	"Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN)."	"441"	"TRUE"
"4194-26_3"	"SL011769"	"AN32B"	"Acidic leucine-rich nuclear phosphoprotein 32 family member B"	"9"	"97983361"	"98015943"	"ANP32B"	"10541"	"Q92688"	"Epithelium TarBase|Lymphocyte TarBase|Muscle cell TarBase|Squamous cell  TarBase"	""	""	""	""	""	""	"Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome."	""	"TRUE"
"4203-50_2"	"SL004920"	"Cofilin-1"	"Cofilin-1"	"11"	"65823022"	"65862026"	"CFL1"	"1072"	"P23528"	"EGF/EGFR Signaling Pathway|G13 Signaling Pathway|Regulation of Actin Cytoskeleton"	"CDC42 signaling events|CXCR4-mediated signaling events|RAC1 signaling pathway|RhoA signaling pathway"	""	"EPHB-mediated forward signaling|Platelet degranulation|Regulation of actin dynamics for phagocytic cup formation|Sema3A PAK dependent Axon repulsion"	"Actin Cytoskeleton Assembly"	""	""	"Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation."	""	"TRUE"
"4209-60_2"	"SL004757"	"DRG-1"	"Vacuolar protein sorting-associated protein VTA1 homolog"	"6"	"142147162"	"142224689"	"VTA1"	"51534"	"Q9NP79"	""	""	""	"Budding and maturation of HIV virion|Endosomal Sorting Complex Required For Transport (ESCRT)"	""	""	""	"Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity). Involved in HIV-1 budding."	""	"FALSE"
"4210-19_2"	"SL009207"	"Dynactin subunit 2"	"Dynactin subunit 2"	"12"	"57530102"	"57547331"	"DCTN2"	"10540"	"Q13561"	"NA"	"NA"	"NA"	"NA"	"NA"	""	""	"Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development."	""	"TRUE"
"4212-5_3"	"SL012188"	"EP15R"	"Epidermal growth factor receptor substrate 15-like 1"	"19"	"16355239"	"16472085"	"EPS15L1"	"58513"	"Q9UBC2"	"EGF/EGFR Signaling Pathway"	""	""	"EGFR downregulation"	""	""	""	"Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2."	""	"TRUE"
"4217-49_3"	"SL004795"	"ERAB"	"3-hydroxyacyl-CoA dehydrogenase type-2"	"X"	"53431258"	"53434373"	"HSD17B10"	"3028"	"Q99714"	"Alzheimers Disease|Tryptophan metabolism"	""	""	"Branched-chain amino acid catabolism"	""	""	""	"Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. Catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD)."	""	"TRUE"
"4220-39_2"	"SL005588"	"FER"	"Tyrosine-protein kinase Fer"	"5"	"108747822"	"109196841"	"FER"	"2241"	"P16591"	"Integrated Breast Cancer Pathway"	"Fc-epsilon receptor I signaling in mast cells|N-cadherin signaling events|Signaling events mediated by PTP1B|Signaling events mediated by Stem cell factor receptor (c-Kit)"	""	"Signaling by SCF-KIT"	"Adherens Junction Assembly (Cadherins)"	""	""	"Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus."	""	"TRUE"
"4224-7_2"	"SL007022"	"HNRPQ"	"Heterogeneous nuclear ribonucleoprotein Q"	"6"	"85607785"	"85643792"	"SYNCRIP"	"10492"	"O60506"	""	""	""	""	""	""	""	"Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function."	""	"TRUE"
"4228-37_2"	"SL004899"	"HSP70 protein 8"	"Heat shock cognate 71 kDa protein"	"11"	"123057489"	"123063230"	"HSPA8"	"3312"	"P11142"	"NA"	"NA"	"NA"	"NA"	"NA"	""	"diagnosis"	"Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase CHIP."	""	"TRUE"
"4230-1_2"	"SL011211"	"IF4G2"	"Eukaryotic translation initiation factor 4 gamma 2"	"11"	"10797050"	"10809110"	"EIF4G2"	"1982"	"P78344"	""	""	""	""	""	""	""	"Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases."	""	"TRUE"
"4232-19_2"	"SL003304"	"IGF-I sR"	"Insulin-like growth factor 1 receptor"	"15"	"98648971"	"98964530"	"IGF1R"	"3480"	"P08069"	"Apoptosis|Endochondral Ossification|Focal Adhesion|Insulin Signaling|MicroRNAs in cardiomyocyte hypertrophy|Senescence and Autophagy|TSH signaling pathway"	"IGF1 pathway|Integrins in angiogenesis|Plasma membrane estrogen receptor signaling|Posttranslational regulation of adherens junction stability and dissassembly|SHP2 signaling|Stabilization and expansion of the E-cadherin adherens junction"	""	"IRS-related events triggered by IGF1R|SHC-related events triggered by IGF1R|Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)"	"IGF1R -> CEBPA/FOXO1A signaling|IGF1R -> ELK-SRF/HIF1A/MYC/SREBF signaling|IGF1R -> MEF/MYOD/MYOG signaling|IGF1R -> STAT signaling"	"linsitinib|cixutumumab|ganitumab|AVE1642|BIIB022|IGF1|ceritinib"	"diagnosis|efficacy|prognosis"	"Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R."	""	"TRUE"
"4234-8_2"	"SL004146"	"IL-1 R4"	"Interleukin-1 receptor-like 1"	"2"	"102311502"	"102352037"	"IL1RL1"	"9173"	"Q01638"	""	""	""	""	""	""	""	"Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function."	"44|228|408|409|415"	"TRUE"
"4237-70_3"	"SL011770"	"LCMT1"	"Leucine carboxyl methyltransferase 1"	"16"	"25111729"	"25178231"	"LCMT1"	"51451"	"Q9UIC8"	""	""	""	""	""	""	""	"Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues."	"26|264"	"TRUE"
"4238-4_2"	"SL012168"	"LIN7B"	"Protein lin-7 homolog B"	"19"	"49114324"	"49118460"	"LIN7B"	"64130"	"Q9HAP6"	""	""	""	"Dopamine Neurotransmitter Release Cycle|RHO GTPases Activate Rhotekin and Rhophilins"	""	""	""	"Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity)."	""	"TRUE"
"4240-31_2"	"SL002650"	"M2-PK"	"Pyruvate kinase PKM"	"15"	"72199029"	"72231822"	"PKM2"	"5315"	"P14618"	"Epithelium TarBase|Glycolysis and Gluconeogenesis|Leukocyte TarBase|Lymphocyte TarBase|Muscle cell TarBase|Squamous cell  TarBase"	"HIF-1-alpha transcription factor network"	"glycolysis"	"Glycolysis"	""	""	"unspecified application"	"Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival."	""	"FALSE"
"4245-80_2"	"SL001999"	"MDM2"	"E3 ubiquitin-protein ligase Mdm2"	"12"	"68808172"	"68850686"	"MDM2"	"4193"	"Q00987"	"Androgen receptor signaling pathway|Apoptosis|Cell cycle|DNA damage response|DNA damage response (only ATM dependent)|ErbB signaling pathway|G1 to S cell cycle control|Integrated Breast Cancer Pathway|Integrated Cancer pathway|Senescence and Autophagy|TP53 network|Tryptophan metabolism|miRNA regulation of DNA Damage Response"	"ATM pathway|ATR signaling pathway|Aurora A signaling|Direct p53 effectors|ErbB4 signaling events|Glucocorticoid receptor regulatory network|Regulation of Androgen receptor activity|Regulation of retinoblastoma protein|Sumoylation by RanBP2 regulates transcriptional repression|Validated transcriptional targets of TAp63 isoforms|Validated transcriptional targets of deltaNp63 isoforms|p53 pathway|p73 transcription factor network"	""	"AKT phosphorylates targets in the cytosol|Constitutive Signaling by AKT1 E17K in Cancer|Oncogene Induced Senescence|Oxidative Stress Induced Senescence|Stabilization of p53|Trafficking of AMPA receptors"	"Apoptosis|Cell Cycle|Sialophorin -> CTNNB/MYC/TP53 signaling"	""	"disease progression|efficacy"	"E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation."	""	"TRUE"
"4246-40_2"	"SL004154"	"NCAM-L1"	"Neural cell adhesion molecule L1"	"X"	"153861514"	"153909223"	"L1CAM"	"3897"	"P32004"	""	"Beta3 integrin cell surface interactions"	""	"Basigin interactions|Interaction between L1 and Ankyrins|L1CAM interactions|Recycling pathway of L1|Signal transduction by L1"	""	""	""	"Cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons."	""	"TRUE"
"4249-64_2"	"SL004921"	"NDP kinase B"	"Nucleoside diphosphate kinase B"	"17"	"51153590"	"51171747"	"NME2"	"4831"	"P22392"	"Nucleotide Metabolism"	"Validated targets of C-MYC transcriptional activation"	""	"Synthesis and interconversion of nucleotide di- and triphosphates"	""	""	""	"Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity."	""	"FALSE"
"4250-23_3"	"SL006268"	"NSF1C"	"NSFL1 cofactor p47"	"20"	"1442162"	"1473842"	"NSFL1C"	"55968"	"Q9UNZ2"	""	""	""	""	""	""	""	"Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro)."	""	"TRUE"
"4252-33_4"	"SL003687"	"Nucleoside diphosphate kinase A"	"Nucleoside diphosphate kinase A"	"17"	"51153536"	"51162428"	"NME1"	"4830"	"P15531"	"NA"	"NA"	"NA"	"NA"	"NA"	""	"unspecified application"	"Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair."	""	"TRUE"
"4254-6_2"	"SL011768"	"NUDC3"	"NudC domain-containing protein 3"	"7"	"44379121"	"44490880"	"NUDCD3"	"23386"	"Q8IVD9"	""	""	""	""	""	""	""	"EBI-744342"	""	"TRUE"
"4258-15_2"	"SL008331"	"PA2G4"	"Proliferation-associated protein 2G4"	"12"	"56104319"	"56113907"	"PA2G4"	"5036"	"Q9UQ80"	""	"Coregulation of Androgen receptor activity"	""	""	""	""	""	"May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity)."	""	"FALSE"
"4261-55_2"	"SL005493"	"paraoxonase 1"	"Serum paraoxonase/arylesterase 1"	"7"	"95297676"	"95324707"	"PON1"	"5444"	"P27169"	"Phase I, non P450"	""	""	""	""	""	"efficacy|unspecified application"	"Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation."	""	"TRUE"
"4267-81_3"	"SL011772"	"PESC"	"Pescadillo homolog"	"22"	"30576625"	"30607083"	"PES1"	"23481"	"O00541"	""	""	""	""	""	""	""	"Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome."	""	"TRUE"
"4271-75_2"	"SL006705"	"PFD5"	"Prefoldin subunit 5"	"12"	"53295291"	"53299450"	"PFDN5"	"5204"	"Q99471"	""	"p73 transcription factor network"	""	"Prefoldin mediated transfer of substrate to CCT/TriC"	""	""	""	"Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC."	""	"TRUE"
"4272-46_2"	"SL000539"	"PHI"	"Glucose-6-phosphate isomerase"	"19"	"34359480"	"34402156"	"GPI"	"2821"	"P06744"	"Glycolysis and Gluconeogenesis"	""	"glycolysis"	"Gluconeogenesis|Glycolysis|TP53 Regulates Metabolic Genes"	""	""	"unspecified application"	"Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons."	""	"TRUE"
"4276-10_2"	"SL005358"	"prostatic binding protein"	"Phosphatidylethanolamine-binding protein 1"	"12"	"118135858"	"118145584"	"PEBP1"	"5037"	"P30086"	"EGF/EGFR Signaling Pathway"	"Aurora B signaling|ErbB1 downstream signaling"	""	""	""	""	"unspecified application"	"Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation."	""	"TRUE"
"4278-14_3"	"SL004901"	"Protein disulfide-isomerase"	"Protein disulfide-isomerase"	"17"	"81843159"	"81860694"	"P4HB"	"5034"	"P07237"	""	""	""	"Chylomicron-mediated lipid transport|Collagen biosynthesis and modifying enzymes|Detoxification of Reactive Oxygen Species|Hedgehog ligand biogenesis"	""	""	""	"This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307)."	""	"TRUE"
"4280-47_2"	"SL008865"	"PSA2"	"Proteasome subunit alpha type-2"	"7"	"42909273"	"42932223"	"PSMA2"	"5683"	"P25787"	"Proteasome Degradation"	""	""	"APC/C:Cdc20 mediated degradation of Securin|APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1|AUF1 (hnRNP D0) destabilizes mRNA|Activation of NF-kappaB in B cells|Antigen processing: Ubiquitination & Proteasome degradation|Asymmetric localization of PCP proteins|Autodegradation of Cdh1 by Cdh1:APC/C|Autodegradation of the E3 ubiquitin ligase COP1|CDK-mediated phosphorylation and removal of Cdc6|CDT1 association with the CDC6:ORC:origin complex|CLEC7A (Dectin-1) signaling|Cdc20:Phospho-APC/C mediated degradation of Cyclin A|Cross-presentation of soluble exogenous antigens (endosomes)|Dectin-1 mediated noncanonical NF-kB signaling|Degradation of GLI1 by the proteasome|Degradation of GLI2 by the proteasome|Degradation of beta-catenin by the destruction complex|ER-Phagosome pathway|GLI3 is processed to GLI3R by the proteasome|Hedgehog 'on' state|Hedgehog ligand biogenesis|Hh mutants that don't undergo autocatalytic processing are degraded by ERAD|Orc1 removal from chromatin|Regulation of activated PAK-2p34 by proteasome mediated degradation|Regulation of ornithine decarboxylase (ODC)|SCF(Skp2)-mediated degradation of p27/p21|SCF-beta-TrCP mediated degradation of Emi1|Separation of Sister Chromatids|Ubiquitin Mediated Degradation of Phosphorylated Cdc25A|Ubiquitin-dependent degradation of Cyclin D1|Vif-mediated degradation of APOBEC3G|Vpu mediated degradation of CD4|degradation of AXIN|degradation of DVL"	""	""	"unspecified application"	"The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMA2 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation."	""	"TRUE"
"4282-3_2"	"SL005034"	"RAN"	"GTP-binding nuclear protein Ran"	"12"	"130871879"	"130877678"	"RAN"	"5901"	"P62826"	"Androgen receptor signaling pathway"	"Aurora A signaling|Canonical NF-kappaB pathway|FoxO family signaling|Role of Calcineurin-dependent NFAT signaling in lymphocytes|Signaling events mediated by HDAC Class I|Signaling events mediated by HDAC Class II|Sumoylation by RanBP2 regulates transcriptional repression"	""	"MicroRNA (miRNA) biogenesis|NEP/NS2 Interacts with the Cellular Export Machinery|Nuclear import of Rev protein|Regulation of cholesterol biosynthesis by SREBP (SREBF)|Rev-mediated nuclear export of HIV RNA|Transcriptional regulation by small RNAs"	"Protein Nuclear Import and Export|RNA Gene Silencing"	""	""	"GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2."	""	"TRUE"
"4284-18_3"	"SL011535"	"RBM39"	"RNA-binding protein 39"	"20"	"35703609"	"35742312"	"RBM39"	"9584"	"Q14498"	"mRNA processing"	""	""	""	""	""	""	"Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1 (By similarity). May be involved in pre-mRNA splicing process."	""	"TRUE"
"4292-5_3"	"SL011202"	"SNAA"	"Alpha-soluble NSF attachment protein"	"19"	"47487637"	"47515240"	"NAPA"	"8775"	"P54920"	""	""	""	"Golgi Associated Vesicle Biogenesis"	"Golgi to Endosome Transport"	""	""	"Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus."	""	"FALSE"
"4294-16_2"	"SL006088"	"Sphingosine kinase 1"	"Sphingosine kinase 1"	"17"	"76376584"	"76387860"	"SPHK1"	"8877"	"Q9NYA1"	"Signal Transduction of S1P Receptor"	"Beta3 integrin cell surface interactions|Fc-epsilon receptor I signaling in mast cells|PDGFR-beta signaling pathway|S1P1 pathway|Sphingosine 1-phosphate (S1P) pathway"	""	"Association of TriC/CCT with target proteins during biosynthesis|Sphingolipid de novo biosynthesis|VEGFR2 mediated cell proliferation"	""	""	"diagnosis|disease progression|prognosis|unspecified application"	"Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol."	""	"TRUE"
"4297-62_3"	"SL005115"	"Spondin-1"	"Spondin-1"	"11"	"13962689"	"14267884"	"SPON1"	"10418"	"Q9HCB6"	""	""	""	"O-glycosylation of TSR domain-containing proteins"	""	""	""	"Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell."	"214"	"TRUE"
"4301-58_2"	"SL000057"	"Thymidine kinase"	"Thymidine kinase, cytosolic"	"17"	"78174075"	"78187233"	"TK1"	"7083"	"P04183"	"Fluoropyrimidine Activity"	"E2F transcription factor network|Validated targets of C-MYC transcriptional activation"	""	"Pyrimidine salvage reactions"	""	""	"diagnosis|prognosis"	"ATP + thymidine = ADP + thymidine 5'-phosphate."	""	"TRUE"
"4304-18_2"	"SL006698"	"transcription factor MLR1, isoform CRA_b"	"Ligand-dependent nuclear receptor corepressor-like protein"	"4"	"17841199"	"18021876"	"LCORL"	"254251"	"Q8N3X6"	""	""	""	""	""	""	""	"May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in spermatogenesis (By similarity)."	""	"TRUE"
"4306-4_2"	"SL003655"	"Transketolase"	"Transketolase"	"3"	"53224707"	"53256052"	"TKT"	"7086"	"P29401"	"Pentose Phosphate Pathway"	""	""	"Insulin effects increased synthesis of Xylulose-5-Phosphate|Pentose phosphate pathway (hexose monophosphate shunt)"	""	""	""	"Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate."	""	"TRUE"
"4309-59_3"	"SL004812"	"Triosephosphate isomerase"	"Triosephosphate isomerase"	"12"	"6867119"	"6870948"	"TPI1"	"7167"	"P60174"	"Fatty Acid Beta Oxidation|Glycolysis and Gluconeogenesis"	""	"gluconeogenesis|glycolysis"	"Gluconeogenesis|Glycolysis"	""	""	"diagnosis|unspecified application"	"D-glyceraldehyde 3-phosphate = glycerone phosphate."	""	"TRUE"
"4314-12_2"	"SL011809"	"XTP3A"	"dCTP pyrophosphatase 1"	"16"	"30423619"	"30430075"	"DCTPP1"	"79077"	"Q9H773"	""	""	""	""	""	""	""	"Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for modified dCTP. Activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified dCTP, 5-methyl-dCTP and 5-chloro-dCTP. Hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even lower activity with unmodified dATP, dTTP and dUTP (in vitro). Does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP. May protect DNA or RNA against the incorporation of non-canonical nucleotide triphosphates. May protect cells against inappropriate methylation of CpG islands by DNA methyltransferases (By similarity)."	""	"TRUE"
"4318-12_3"	"SL004940"	"PTP-1C"	"Tyrosine-protein phosphatase non-receptor type 6"	"12"	"6946468"	"6961316"	"PTPN6"	"5777"	"P29350"	"B Cell Receptor Signaling Pathway|IL-3 Signaling Pathway|IL-4 signaling pathway|Kit receptor signaling pathway|Regulation of toll-like receptor signaling pathway"	"BCR signaling pathway|CXCR4-mediated signaling events|EGF receptor (ErbB1) signaling pathway|EPO signaling pathway|IL4-mediated signaling events|Posttranslational regulation of adherens junction stability and dissassembly|Signaling events mediated by Stem cell factor receptor (c-Kit)|Signaling events mediated by VEGFR1 and VEGFR2|TCR signaling in naïve CD4+ T cells|TCR signaling in naïve CD8+ T cells"	""	"Costimulation by the CD28 family|Growth hormone receptor signaling|Interferon alpha/beta signaling|Interferon gamma signaling|Interleukin receptor SHC signaling|Interleukin-3, 5 and GM-CSF signaling|PD-1 signaling|PECAM1 interactions|Platelet sensitization by LDL|Regulation of IFNA signaling|Regulation of IFNG signaling|Regulation of KIT signaling|Signal regulatory protein (SIRP) family interactions"	"DCIR1 (CLEC4A) Signaling|Natural Killer Cell Inhibitory Receptor Signaling|Peripheral T-cell Tolerance Overview|Regulatory T-cell Differentiation|T-cell Receptor Signaling|T-cell receptor -> AP-1 signaling|T-cell receptor -> ATF/CREB signaling|T-cell receptor -> CREBBP signaling|T-cell receptor -> NF-kB signaling|T-cell receptor -> NFATC signaling|T-cell receptor -> STAT signaling|T-cell-Dependent B-cell Activation"	""	""	"Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis."	""	"TRUE"
"4322-28_3"	"SL013489"	"AMNLS"	"Protein amnionless"	"14"	"102922656"	"102933596"	"AMN"	"81693"	"Q9BXJ7"	""	""	""	"Cobalamin (Cbl, vitamin B12) transport and metabolism|Defective AMN causes hereditary megaloblastic anemia 1|Defective CUBN causes hereditary megaloblastic anemia 1|HDL-mediated lipid transport"	""	""	""	"Necessary for efficient absorption of vitamin B12. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm (By similarity)."	""	"TRUE"
"4324-33_2"	"SL008516"	"CYTT"	"Cystatin-SA"	"20"	"23823769"	"23826731"	"CST2"	"1470"	"P09228"	""	""	""	""	""	""	""	"Thiol protease inhibitor."	"110|248"	"TRUE"
"4328-2_2"	"SL013490"	"BOC"	"Brother of CDO"	"3"	"113211003"	"113287459"	"BOC"	"91653"	"Q9BWV1"	""	"Signaling events mediated by the Hedgehog family"	""	"CDO in myogenesis|Ligand-receptor interactions"	""	""	""	"Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells."	""	"TRUE"
"4330-4_2"	"SL000062"	"PSA"	"Prostate-specific antigen"	"19"	"50854915"	"50860764"	"KLK3"	"354"	"P07288"	"NA"	"NA"	"NA"	"NA"	"NA"	""	"diagnosis|disease progression|efficacy|prognosis|safety|unspecified application"	"Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum."	""	"TRUE"
"4332-6_2"	"SL013488"	"CLC1B"	"C-type lectin domain family 1 member B"	"12"	"9985642"	"10013424"	"CLEC1B"	"51266"	"Q9P126"	""	""	""	""	""	""	""	"Homodimer. Interacts (via cytoplasmic domain) with RACK1; promotes CLEC1B ubiquitination and proteasome-mediated degradation. Interacts (dimer) with SYK (via SH2 domains)."	""	"FALSE"
"4336-2_1"	"SL000572"	"SAA"	"Serum amyloid A-1 protein"	"11"	"18266174"	"18269977"	"SAA1"	"6288"	"P0DJI8"	""	""	""	"Advanced glycosylation endproduct receptor signaling|Amyloids|DEx/H-box helicases activate type I IFN and inflammatory cytokines production|Formyl peptide receptors bind formyl peptides and many other ligands|G alpha (i) signalling events|G alpha (q) signalling events|RIP-mediated NFkB activation via ZBP1|Scavenging by Class B Receptors|TAK1 activates NFkB by phosphorylation and activation of IKKs complex|TRAF6 mediated NF-kB activation"	""	""	"diagnosis|unspecified application"	"Major acute phase protein."	"22|121|233"	"TRUE"
"4337-49_2"	"SL000051"	"CRP"	"C-reactive protein"	"1"	"159712289"	"159714589"	"CRP"	"1401"	"P02741"	"Folate Metabolism|IL-6 signaling pathway|Selenium Pathway|Vitamin B12 Metabolism"	"IL6-mediated signaling events"	""	"Classical antibody-mediated complement activation"	""	""	"diagnosis|disease progression|efficacy|prognosis|safety|unspecified application"	"Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells."	""	"TRUE"
"4342-10_3"	"SL002922"	"sICAM-1"	"Intercellular adhesion molecule 1"	"19"	"10270835"	"10286615"	"ICAM1"	"3383"	"P05362"	"Folate Metabolism|RANKL/RANK Signaling Pathway|Selenium Pathway|Type II interferon signaling (IFNG)|Vitamin B12 Metabolism"	"Beta2 integrin cell surface interactions|Glucocorticoid receptor regulatory network|Thromboxane A2 receptor signaling|amb2 Integrin signaling"	""	"Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell|Integrin cell surface interactions|Interferon gamma signaling"	"Cell Death Mediated by Cytotoxic Cells|ICAM1 -> AP-1/CREB/ELK-SRF signaling|Leukocyte Adhesion to Endothelial Cell|MacrophageR -> CEBPB/NF-kB signaling|Natural Killer Cell Activation|Natural Killer Cell Activation through Integrins and non-ITAM-Containing Receptors|Nociception-related CCR1 expression targets|Nociception-related IL1B expression targets|Summarized nociception-related expression targets"	""	"diagnosis|efficacy|prognosis|unspecified application"	"ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation."	"1"	"TRUE"
"4355-13_1"	"SL007752"	"DAPK2"	"Death-associated protein kinase 2"	"15"	"63907036"	"64072033"	"DAPK2"	"23604"	"Q9UIK4"	""	""	""	"Ligand-independent caspase activation via DCC"	""	""	""	"Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (PubMed:17347302). Regulates granulocytic motility by controlling cell spreading and polarization (PubMed:24163421)."	"224"	"TRUE"
"4359-87_1"	"SL013570"	"DYRK3"	"Dual specificity tyrosine-phosphorylation-regulated kinase 3"	"1"	"206635536"	"206684419"	"DYRK3"	"8444"	"O43781"	""	""	""	""	""	""	""	"Negative regulator of EPO-dependent erythropoiesis, may place an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. May act by regulating CREB/CRE signaling."	""	"TRUE"
"4368-8_2"	"SL000305"	"b-NGF"	"beta-nerve growth factor"	"1"	"115285918"	"115338236"	"NGF"	"4803"	"P01138"	"NA"	"NA"	"NA"	"NA"	"NA"	""	""	"Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177)."	""	"TRUE"
"4383-97_1"	"SL004837"	"Activin AB"	"Inhibin beta A chain:Inhibin beta B chain heterodimer"	"2|7"	"120346143|41685114"	"120351808|41703108"	"INHBA|INHBB"	"3624|3625"	"P08476|P09529"	"NA"	"NA"	"NA"	"NA"	"NA"	""	"diagnosis"	"Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins."	""	"TRUE"
"4389-2_1"	"SL007003"	"DHH"	"Desert hedgehog protein N-product"	"12"	"49089421"	"49094819"	"DHH"	"50846"	"O43323"	"Hedgehog Signaling Pathway"	"Signaling events mediated by the Hedgehog family"	""	"Class B/2 (Secretin family receptors)|Hedgehog ligand biogenesis|Ligand-receptor interactions|Release of Hh-Np from the secreting cell"	""	""	""	"Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development."	""	"TRUE"
"4392-54_2"	"SL005161"	"FGF-12"	"Fibroblast growth factor 12"	"3"	"192139395"	"192767764"	"FGF12"	"2257"	"P61328"	"Regulation of Actin Cytoskeleton"	""	""	""	""	""	""	"Probably involved in nervous system development and function."	""	"TRUE"
"4393-3_1"	"SL004334"	"FGF-16"	"Fibroblast growth factor 16"	"X"	"77447405"	"77457278"	"FGF16"	"8823"	"O43320"	""	""	""	"Activated point mutants of FGFR2|Constitutive Signaling by Aberrant PI3K in Cancer|FGFR2c ligand binding and activation|FGFR3 mutant receptor activation|FGFR3c ligand binding and activation|FGFR4 ligand binding and activation|FRS-mediated FGFR2 signaling|FRS-mediated FGFR3 signaling|FRS2-mediated FGFR4 signaling|Negative regulation of FGFR2 signaling|Negative regulation of FGFR3 signaling|Negative regulation of FGFR4 signaling|PI-3K cascade:FGFR2|PI-3K cascade:FGFR3|PI-3K cascade:FGFR4|PI3K Cascade|PIP3 activates AKT signaling|Phospholipase C-mediated cascade, FGFR2|Phospholipase C-mediated cascade, FGFR3|Phospholipase C-mediated cascade, FGFR4|SHC-mediated cascade:FGFR2|SHC-mediated cascade:FGFR3|SHC-mediated cascade:FGFR4|Signaling by FGFR2 mutants|Signaling by FGFR3 mutants|Signaling by FGFR4 mutants|Signaling by activated point mutants of FGFR3"	""	""	""	"Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development."	""	"TRUE"
"4394-71_2"	"SL014308"	"FGF-8A"	"Fibroblast growth factor 8 isoform A"	"10"	"101770130"	"101780369"	"FGF8"	"2253"	"P55075"	"Heart Development|Neural Crest Differentiation|Proteins and DNA Sequences in Cardicac Structures|Regulation of Actin Cytoskeleton"	"FGF signaling pathway"	""	"Activated point mutants of FGFR2|Constitutive Signaling by Aberrant PI3K in Cancer|FGFR1c ligand binding and activation|FGFR2c ligand binding and activation|FGFR3 mutant receptor activation|FGFR3b ligand binding and activation|FGFR3c ligand binding and activation|FGFR4 ligand binding and activation|FRS-mediated FGFR1 signaling|FRS-mediated FGFR2 signaling|FRS-mediated FGFR3 signaling|FRS2-mediated FGFR4 signaling|Negative regulation of FGFR1 signaling|Negative regulation of FGFR2 signaling|Negative regulation of FGFR3 signaling|Negative regulation of FGFR4 signaling|PI-3K cascade:FGFR1|PI-3K cascade:FGFR2|PI-3K cascade:FGFR3|PI-3K cascade:FGFR4|PI3K Cascade|PIP3 activates AKT signaling|Phospholipase C-mediated cascade, FGFR2|Phospholipase C-mediated cascade, FGFR3|Phospholipase C-mediated cascade, FGFR4|Phospholipase C-mediated cascade: FGFR1|SHC-mediated cascade:FGFR1|SHC-mediated cascade:FGFR2|SHC-mediated cascade:FGFR3|SHC-mediated cascade:FGFR4|Signaling by FGFR1 mutants|Signaling by FGFR2 mutants|Signaling by FGFR3 mutants|Signaling by FGFR4 mutants|Signaling by activated point mutants of FGFR1|Signaling by activated point mutants of FGFR3"	"FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling|FGFR -> RUNX2 signaling|FGFR3 -> STAT signaling"	""	""	"Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system (PubMed:16384934, PubMed:16597617, PubMed:8663044). Plays a role in neurite outgrowth in hippocampal cells (PubMed:21576111)."	""	"TRUE"
"4396-54_1"	"SL004348"	"IFN-lambda 1"	"Interferon lambda-1"	"19"	"39296325"	"39298673"	"IFNL1"	"282618"	"Q8IU54"	""	""	""	""	""	""	""	"Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression."	""	"TRUE"
"4397-26_2"	"SL004349"	"IFN-lambda 2"	"Interferon lambda-2"	"19"	"39268514"	"39270092"	"IFNL2"	"282616"	"Q8IZJ0"	""	""	""	""	""	""	""	"Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression."	""	"TRUE"
"4407-10_1"	"SL005202"	"MSP"	"Hepatocyte growth factor-like protein"	"3"	"49683947"	"49689501"	"MST1"	"4485"	"P26927"	""	"FoxO family signaling|a6b1 and a6b4 Integrin signaling|amb2 Integrin signaling"	""	""	""	""	""	"Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts (via beta chain) with MST1R (via SEMA domain)."	"4|130|313|376"	"TRUE"
"4413-3_2"	"SL001888"	"SLPI"	"Antileukoproteinase"	"20"	"45252239"	"45254564"	"SLPI"	"6590"	"P03973"	""	""	""	""	""	""	"diagnosis|prognosis"	"Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G (PubMed:3533531, PubMed:3462719, PubMed:2039600, PubMed:2110563, PubMed:10702419, PubMed:24121345). Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS) (By similarity). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses (PubMed:10702419, PubMed:24352879). Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for normal resistance to infection by L.major. Required for normal wound healing, probably by preventing tissue damage by limiting protease activity (By similarity). Together with ELANE, required for normal differentiation and proliferation of bone marrow myeloid cells (PubMed:24352879)."	""	"TRUE"
"4414-69_2"	"SL004484"	"SP-D"	"Pulmonary surfactant-associated protein D"	"10"	"79937740"	"79982614"	"SFTPD"	"6441"	"P35247"	"Regulation of toll-like receptor signaling pathway"	"FOXA1 transcription factor network|Regulation of retinoblastoma protein"	""	"Signal regulatory protein (SIRP) family interactions|Toll Like Receptor 4 (TLR4) Cascade|Toll Like Receptor TLR1:TLR2 Cascade"	""	""	"efficacy"	"Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties."	""	"TRUE"
"4420-7_2"	"SL009988"	"ADAM12"	"Disintegrin and metalloproteinase domain-containing protein 12"	"10"	"126012381"	"126388455"	"ADAM12"	"8038"	"O43184"	""	"Alpha9 beta1 integrin signaling events|Notch signaling pathway|Syndecan-4-mediated signaling events"	""	"Signaling by EGFR"	""	""	"diagnosis"	"Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity)."	""	"TRUE"
"4423-77_2"	"SL003674"	"BCL2-like 1 protein"	"Bcl-2-like protein 1"	"20"	"31664452"	"31723989"	"BCL2L1"	"598"	"Q07817"	"Apoptosis|Apoptosis Modulation and Signaling|IL-3 Signaling Pathway|IL-6 signaling pathway|IL-7 signaling pathway|Leptin signaling pathway|TNF alpha Signaling Pathway"	"ATF-2 transcription factor network|CD40/CD40L signaling|Caspase Cascade in Apoptosis|Class I PI3K signaling events mediated by Akt|Direct p53 effectors|EPO signaling pathway|ErbB1 downstream signaling|IL2 signaling events mediated by PI3K|IL2 signaling events mediated by STAT5|IL3-mediated signaling events|IL4-mediated signaling events|IL6-mediated signaling events|Role of Calcineurin-dependent NFAT signaling in lymphocytes"	""	"BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members|The NLRP1 inflammasome"	"Apoptosis|Central T-cell Tolerance|T-cell Positive Selection and Neglect-Induced Death"	""	"efficacy|prognosis"	"Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis."	""	"TRUE"
"4428-1_2"	"SL013988"	"CHST2"	"Carbohydrate sulfotransferase 2"	"3"	"143119331"	"143124014"	"CHST2"	"9435"	"Q9Y4C5"	"metapathway biotransformation"	""	""	"Keratan sulfate biosynthesis"	""	""	""	"Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer patches. Has no activity toward O-linked sugars. Its substrate specificity may be influenced by its subcellular location. Sulfates GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains."	""	"TRUE"
"4429-51_2"	"SL014130"	"CHST6"	"Carbohydrate sulfotransferase 6"	"16"	"75472052"	"75495384"	"CHST6"	"4166"	"Q9GZX3"	"metapathway biotransformation"	""	""	"Defective CHST6 causes MCDC1|Keratan sulfate biosynthesis"	""	""	""	"Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues of keratan. Mediates sulfation of keratan in cornea. Keratan sulfate plays a central role in maintaining corneal transparency. Acts on the non-reducing terminal GlcNAc of short and long carbohydrate substrates that have poly-N-acetyllactosamine structures."	""	"TRUE"
"4430-44_3"	"SL006713"	"Collectin Kidney 1"	"Collectin-11"	"2"	"3594832"	"3644644"	"COLEC11"	"78989"	"Q9BWP8"	""	""	""	"Scavenging by Class A Receptors"	""	""	"NA"	"Lectin that binds to various sugars including fucose and mannose. Has a higher affinity for fucose compared to mannose. Does not bind to glucose, N-acetylglucosamine and N-acetylgalactosamine. Also binds lipopolysaccharides (LPS). Involved in fundamental development serving as a guidance cue for neural crest cell migration (By similarity)."	"93"	"TRUE"
"4435-66_2"	"SL009045"	"ENPP7"	"Ectonucleotide pyrophosphatase/phosphodiesterase family member 7"	"17"	"79730919"	"79742222"	"ENPP7"	"339221"	"Q6UWV6"	""	""	""	""	""	""	""	"Converts sphingomyelin to ceramide. Also has phospholipase C activity toward palmitoyl lyso-phosphocholine. Does not appear to have nucleotide pyrophosphatase activity."	""	"TRUE"
"4436-1_2"	"SL014093"	"ENTP3"	"Ectonucleoside triphosphate diphosphohydrolase 3"	"3"	"40387156"	"40428619"	"ENTPD3"	"956"	"O75355"	""	""	""	""	""	""	""	"Has a threefold preference for the hydrolysis of ATP over ADP."	""	"TRUE"
"4437-56_3"	"SL014028"	"ENTP5"	"Ectonucleoside triphosphate diphosphohydrolase 5"	"14"	"73958010"	"74019399"	"ENTPD5"	"957"	"O75356"	""	""	"protein glycosylation"	""	""	""	""	"Uridine diphosphatase (UDPase) that promotes protein N-glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling."	"61|226"	"TRUE"
"4440-15_2"	"SL014088"	"FCRL3"	"Fc receptor-like protein 3"	"1"	"157674321"	"157700857"	"FCRL3"	"115352"	"Q96P31"	""	""	""	""	""	""	""	"Interacts with PTPN6, PTPN11, SYK and ZAP70."	"64"	"TRUE"
"4449-67_3"	"SL007024"	"GREM1"	"Gremlin-1"	"15"	"32717974"	"32814964"	"GREM1"	"26585"	"O60565"	""	"BMP receptor signaling"	""	""	""	""	"unspecified application"	"Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Acts as inhibitor of monocyte chemotaxis (By similarity)."	""	"TRUE"
"4450-26_2"	"SL009791"	"hnRNP A/B"	"Heterogeneous nuclear ribonucleoprotein A/B"	"5"	"178204507"	"178211180"	"HNRNPAB"	"3182"	"Q99729"	"mRNA processing"	""	""	""	""	""	""	"Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site."	""	"TRUE"
"4452-9_2"	"SL014096"	"LRRT1"	"Leucine-rich repeat transmembrane neuronal protein 1"	"2"	"80288351"	"80304749"	"LRRTM1"	"347730"	"Q86UE6"	""	""	""	""	""	""	""	"Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level."	""	"TRUE"
"4453-83_3"	"SL014108"	"LRRT3"	"Leucine-rich repeat transmembrane neuronal protein 3"	"10"	"66926006"	"67099830"	"LRRTM3"	"347731"	"Q86VH5"	""	""	""	""	""	""	""	"Exhibits a limited synaptogenic activity in vitro, restricted to excitatory presynaptic differentiation (By similarity). May play a role in the development and maintenance of the vertebrate nervous system."	""	"TRUE"
"4455-89_2"	"SL006523"	"MFGM"	"Lactadherin"	"15"	"88898683"	"88913411"	"MFGE8"	"4240"	"Q08431"	""	"Integrins in angiogenesis|Validated transcriptional targets of TAp63 isoforms"	""	"Amyloids"	""	""	""	"Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Binds specifically to rotavirus and inhibits its replication."	"396"	"TRUE"
"4459-68_2"	"SL014069"	"PCSK7"	"Proprotein convertase subtilisin/kexin type 7"	"11"	"117204337"	"117232525"	"PCSK7"	"9159"	"Q16549"	""	""	""	""	""	""	"unspecified application"	"Likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif."	"21|243|317"	"TRUE"
"4460-8_2"	"SL006998"	"PDPK1"	"3-phosphoinositide-dependent protein kinase 1"	"16"	"2537964"	"2603188"	"PDPK1"	"5170"	"O15530"	"B Cell Receptor Signaling Pathway|EGF/EGFR Signaling Pathway|Focal Adhesion|Insulin Signaling|Integrin-mediated cell adhesion|MicroRNAs in cardiomyocyte hypertrophy|Serotonin HTR1 Group and FOS Pathway|TCR Signaling Pathway|TSH signaling pathway|angiogenesis overview"	"BCR signaling pathway|CXCR3-mediated signaling events|CXCR4-mediated signaling events|Class I PI3K signaling events|Class I PI3K signaling events mediated by Akt|ErbB1 downstream signaling|FAS (CD95) signaling pathway|FGF signaling pathway|IGF1 pathway|IL8- and CXCR1-mediated signaling events|IL8- and CXCR2-mediated signaling events|Insulin Pathway|Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)|Signaling events mediated by Stem cell factor receptor (c-Kit)|Signaling events mediated by VEGFR1 and VEGFR2|TCR signaling in naïve CD4+ T cells|TCR signaling in naïve CD8+ T cells|TGF-beta receptor signaling|Trk receptor signaling mediated by PI3K and PLC-gamma|VEGFR1 specific signals|mTOR signaling pathway"	""	"Activation of PKB|CD28 dependent PI3K/Akt signaling|CLEC7A (Dectin-1) signaling|CTLA4 inhibitory signaling|Constitutive Signaling by AKT1 E17K in Cancer|Downstream TCR signaling|FCERI mediated NF-kB activation|G beta:gamma signalling through PI3Kgamma|GPVI-mediated activation cascade|Integrin alphaIIb beta3 signaling|PIP3 activates AKT signaling|RHO GTPases activate PKNs|RSK activation|Role of LAT2/NTAL/LAB on calcium mobilization|VEGFR2 mediated cell proliferation|VEGFR2 mediated vascular permeability"	"AGER ->  NF-kB signaling|AdenosineR -> NF-kB signaling|AdrenergicRb -> STAT3 signaling|AngiopoietinR -> AP-1 signaling|AngiopoietinR -> FOXO signaling|BDKRB1/2 -> interleukins production|BDKRB1/2 -> vasodilation|CD19 -> NF-kB signaling|CD38 ->  NF-kB signaling|CD8+ T-cell Activation|CHRM1 -> IL2 production|CHRM1/2/3/5 -> ion channels|CNR1/2 -> IL1B/2/4/6/10 production|CNR1/2 -> membrane transport|CannabinoidR -> AP-1/EGR signaling|Central T-cell Tolerance|CholinergicRm -> CREB/ELK-SRF signaling|DRD2 -> TRPC1 transcription|DRD2/4 -> membrane transport|DopamineR2 -> AP-1/CREB/ELK-SRF signaling|DopamineR2 -> NF-kB signaling|EDG2 -> ELK-SRF signaling|EGFR -> AP-1/ATF2 signaling|EGFR -> AP-1/CREB/ELK-SRF/MYC signaling|EGFR -> NCOR2 signaling|EGFR/ERBB2 -> HIF1A signaling|EGFR/ERBB2 -> TP53 signaling|EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG signaling|ERBB2/3 -> EP300/ETS/ETV/SP1 signaling|ErythropoietinR -> AP-1/CREB/MYC signaling|ErythropoietinR -> ELK-SRF/FOS signaling|ErythropoietinR -> FOXO3A signaling|ErythropoietinR -> NF-kB signaling|FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling|FSHR -> FOXO1A signaling|FcIgER -> ELK-SRF signaling|FibronectinR -> AP-1/ELK-SRF/SREBF signaling|FibronectinR -> CTNNB signaling|FibronectinR -> NF-kB signaling|GALR1/2/3 -> POMC/NPY production|GDNF -> HSF1 signaling|GFs/TNF -> ion channels|GHR -> ELK-SRF/MYC signaling|GHR -> NF-kB signaling|HGFR -> AP-1/CREB/MYC signaling|HGFR -> FOXO3A signaling|HTR1 -> IL6 production|HTR1 -> membrane transport|HTR5 -> TNF production|ICAM2 -> CTNNB/FOXO/STAT3 signaling|IGF1R -> CEBPA/FOXO1A signaling|IGF1R -> MEF/MYOD/MYOG signaling|IL12R -> NF-kB/NFATC signaling|IL15R -> NF-kB/NFATC signaling|IL2R -> ELK-SRF/MYC signaling|IL4R -> ELK-SRF/HMGY signaling|IL7R -> FOXO/NF-kB signaling|InsulinR -> CTNNB/FOXA/FOXO signaling|InsulinR -> ELK-SRF/SREBF signaling|KIT -> MITF signaling|Leptin -> NO production/vasodilation|MacrophageR -> CEBPB/NF-kB signaling|Model of T-cell Maturation|NPY1R -> CRH/POMC production|NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling|NTRK -> FOXO/MYCN signaling|NTRK1/2/3 -> acetylcholine production|Natural Killer Cell Activation through C-type Lectin-like Receptors|Natural Killer Cell Activation through ITAM-Containing Receptors|Natural Killer Cell Activation through ITSM-Containing Receptors|NeuropeptideYR -> ATF/CREB signaling|NeurotensinR -> ELK-SRF/AP-1/EGR signaling|Nociception-related DRD2 expression targets|Nociception-related NTSR1 expression targets|Notch -> NF-kB signaling|PDGFR -> AP-1/MYC signaling|PDGFR -> FOXO3A signaling|PTAFR -> AP-1/ATF1/CREB/ERK-SRF signaling|PTAFR -> NF-kB signaling|PTGER2/3 -> vascular motility|Peripheral T-cell Tolerance Overview|Regulation of calcium flux|Regulation of potassium flux|Regulation of sodium flux|Regulatory T-cell Differentiation|SerotoninR1 -> FOS signaling|Summarized nociception-related expression targets|Summarized vascular motility pathway|T-cell Positive Selection and Neglect-Induced Death|T-cell Receptor Signaling|T-cell-Dependent B-cell Activation|T-cell-Independent B-cell Activation|TACR1 -> TNF/IL6/IL8 production|TLR1/2/6 -> NF-kB signaling|TNFRSF5/13B -> NFATC1 signaling|Th1 Cell Differentiation|Th17 Cell Differentiation|Th2 Cell Differentiation|ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling|ThrombinR -> NF-kB signaling|ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling|ThrombopoietinR -> SPI1 signaling|Toll-like Receptors Act through MYD88-TIRAP Signaling|UrokinaseR -> ELK-SRF signaling|VEGFR -> AP-1/CREB/MYC signaling|VEGFR -> CTNNB signaling|VEGFR -> FOXO3A signaling|VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling|VasopressinR1 -> MEF/MYOD/NFATC/MYOG signaling|VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling|VasopressinR2 -> MEF/MYOD/NFATC/MYOG signaling"	""	""	"Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), protein kinase PKN (PKN1 and PKN2). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage. Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta. Activates PPARG transcriptional activity and promotes adipocyte differentiation. Activates the NF-kappa-B pathway via phosphorylation of IKKB. The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II. Controls proliferation, survival, and growth of developing pancreatic cells. Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells. Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis. Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response. Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses. Provides negative feedback inhibition to toll-like receptor-mediated NF-kappa-B activation in macrophages. Isoform 3 is catalytically inactive."	""	"TRUE"
"4462-8_2"	"SL013754"	"RASA1"	"Ras GTPase-activating protein 1"	"5"	"87267888"	"87391931"	"RASA1"	"5921"	"P20936"	"NA"	"NA"	"NA"	"NA"	"NA"	""	""	"Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the presence of NCK1."	""	"TRUE"
"4464-10_2"	"SL001753"	"Sialoadhesin"	"Sialoadhesin"	"20"	"3686970"	"3707128"	"SIGLEC1"	"6614"	"Q9BZZ2"	""	""	""	""	""	""	"diagnosis"	"Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis."	""	"TRUE"
"4467-49_2"	"SL005488"	"SPARCL1"	"SPARC-like protein 1"	"4"	"87473335"	"87531061"	"SPARCL1"	"8404"	"Q14515"	""	""	""	""	""	""	"disease progression"	"Secreted"	"68|402"	"TRUE"
"4468-21_2"	"SL014029"	"SPHK2"	"Sphingosine kinase 2"	"19"	"48619291"	"48630717"	"SPHK2"	"56848"	"Q9NRA0"	"Signal Transduction of S1P Receptor"	"Ceramide signaling pathway|IL12-mediated signaling events|Sphingosine 1-phosphate (S1P) pathway"	""	"Sphingolipid de novo biosynthesis"	""	""	""	"Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides."	""	"TRUE"
"4469-78_2"	"SL007502"	"ST4S6"	"Carbohydrate sulfotransferase 15"	"10"	"124007666"	"124093607"	"CHST15"	"51363"	"Q7LFX5"	""	""	""	"Chondroitin sulfate biosynthesis"	""	""	""	"Sulfotransferase that transfers sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc(4,6-SO(4)) repeating units. It also transfers sulfate to a unique non-reducing terminal sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure found in thrombomodulin chondroitin sulfate. May also act as a B-cell receptor involved in BCR ligation-mediated early activation that mediate regulatory signals key to B-cell development and/or regulation of B-cell-specific RAG expression; however such results are unclear in vivo."	"28"	"TRUE"
"4471-50_2"	"SL008945"	"TGM3"	"Protein-glutamine gamma-glutamyltransferase E"	"20"	"2296001"	"2341078"	"TGM3"	"7053"	"Q08188"	""	""	""	""	""	""	"unspecified application"	"Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath."	""	"TRUE"
"4472-5_2"	"SL004908"	"Tropomyosin 2"	"Tropomyosin beta chain"	"9"	"35681992"	"35691020"	"TPM2"	"7169"	"P07951"	"Lymphocyte TarBase|Muscle cell TarBase|Striated Muscle Contraction"	""	""	"Smooth Muscle Contraction|Striated Muscle Contraction"	""	""	"diagnosis"	"Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (By similarity)."	""	"TRUE"
"4474-19_2"	"SL004070"	"Ubiquitin"	"Ubiquitin"	"2"	"55231903"	"55235853"	"RPS27A"	"6233"	"P62979"	"Cytoplasmic Ribosomal Proteins"	""	""	"APC-Cdc20 mediated degradation of Nek2A|APC/C:Cdc20 mediated degradation of Cyclin B|APC/C:Cdc20 mediated degradation of Securin|APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1|AUF1 (hnRNP D0) destabilizes mRNA|Activated NOTCH1 Transmits Signal to the Nucleus|Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon|Activation of NF-kappaB in B cells|Antigen processing: Ubiquitination & Proteasome degradation|Assembly Of The HIV Virion|Association of licensing factors with the pre-replicative complex|Asymmetric localization of PCP proteins|Autodegradation of Cdh1 by Cdh1:APC/C|Autodegradation of the E3 ubiquitin ligase COP1|Budding and maturation of HIV virion|CDK-mediated phosphorylation and removal of Cdc6|CDT1 association with the CDC6:ORC:origin complex|CLEC7A (Dectin-1) signaling|Cdc20:Phospho-APC/C mediated degradation of Cyclin A|Circadian Clock|Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants|Constitutive Signaling by NOTCH1 HD Domain Mutants|Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants|Constitutive Signaling by NOTCH1 PEST Domain Mutants|Cyclin D associated events in G1|Dectin-1 mediated noncanonical NF-kB signaling|Degradation of GLI1 by the proteasome|Degradation of GLI2 by the proteasome|Degradation of beta-catenin by the destruction complex|Downregulation of ERBB2:ERBB3 signaling|Downregulation of ERBB4 signaling|Downregulation of SMAD2/3:SMAD4 transcriptional activity|Downregulation of TGF-beta receptor signaling|Downstream TCR signaling|EGFR downregulation|ER-Phagosome pathway|Endosomal Sorting Complex Required For Transport (ESCRT)|Eukaryotic Translation Termination|FCERI mediated NF-kB activation|Fanconi Anemia pathway|Formation of a pool of free 40S subunits|Formation of the ternary complex, and subsequently, the 43S complex|GLI3 is processed to GLI3R by the proteasome|GTP hydrolysis and joining of the 60S ribosomal subunit|Glycogen synthesis|Hedgehog 'on' state|Hedgehog ligand biogenesis|Hh mutants that don't undergo autocatalytic processing are degraded by ERAD|IKK complex recruitment mediated by RIP1|IRAK1 recruits IKK complex|IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation|IRAK2 mediated activation of TAK1 complex|IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation|ISG15 antiviral mechanism|Interleukin-1 signaling|JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1|L13a-mediated translational silencing of Ceruloplasmin expression|Membrane binding and targetting of GAG proteins|Myoclonic epilepsy of Lafora|NF-kB is activated and signals survival|NOD1/2 Signaling Pathway|NOTCH1 Intracellular Domain Regulates Transcription|NOTCH2 Activation and Transmission of Signal to the Nucleus|NRIF signals cell death from the nucleus|Negative regulation of FGFR1 signaling|Negative regulation of FGFR2 signaling|Negative regulation of FGFR3 signaling|Negative regulation of FGFR4 signaling|Negative regulators of RIG-I/MDA5 signaling|Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)|Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)|Oncogene Induced Senescence|Orc1 removal from chromatin|Oxidative Stress Induced Senescence|Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha|Peptide chain elongation|RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways|Recognition of DNA damage by PCNA-containing replication complex|Regulation of PLK1 Activity at G2/M Transition|Regulation of activated PAK-2p34 by proteasome mediated degradation|Regulation of innate immune responses to cytosolic DNA|Regulation of necroptotic cell death|Regulation of signaling by CBL|Regulation of the Fanconi anemia pathway|Ribosomal scanning and start codon recognition|SCF(Skp2)-mediated degradation of p27/p21|SCF-beta-TrCP mediated degradation of Emi1|SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription|SRP-dependent cotranslational protein targeting to membrane|Senescence-Associated Secretory Phenotype (SASP)|Separation of Sister Chromatids|Signaling by ERBB2|Spry regulation of FGF signaling|Stimuli-sensing channels|TAK1 activates NFkB by phosphorylation and activation of IKKs complex|TCF dependent signaling in response to WNT|TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)|TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling|TRAF6 mediated induction of TAK1 complex|Termination of translesion DNA synthesis|Translation initiation complex formation|Translesion Synthesis by POLH|Translesion synthesis by POLI|Translesion synthesis by POLK|Translesion synthesis by REV1|Ubiquitin Mediated Degradation of Phosphorylated Cdc25A|Ubiquitin-dependent degradation of Cyclin D1|Vif-mediated degradation of APOBEC3G|Viral mRNA Translation|Vpu mediated degradation of CD4|activated TAK1 mediates p38 MAPK activation|deactivation of the beta-catenin transactivating complex|degradation of AXIN|degradation of DVL|p75NTR recruits signalling complexes|regulation of FZD by ubiquitination"	""	""	""	"Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling."	""	"TRUE"
"4476-22_2"	"SL010519"	"ZAP70"	"Tyrosine-protein kinase ZAP-70"	"2"	"97713560"	"97739862"	"ZAP70"	"7535"	"P43403"	"Inflammatory Response Pathway|Prolactin Signaling Pathway|TCR Signaling Pathway"	"Class I PI3K signaling events|TCR signaling in naïve CD4+ T cells|TCR signaling in naïve CD8+ T cells"	""	"Generation of second messenger molecules|Translocation of ZAP-70 to Immunological synapse"	"CD2 -> NFATC1 signaling|CD2 -> STAT signaling|CD8+ T-cell Activation|Central T-cell Tolerance|FcIgER -> ELK-SRF signaling|FcIgER -> NFATC1 signaling|Model of T-cell Maturation|Natural Killer Cell Activation|Natural Killer Cell Activation through ITAM-Containing Receptors|Natural Killer Cell Inhibitory Receptor Signaling|Peripheral T-cell Tolerance Overview|Regulatory T-cell Differentiation|T-cell Positive Selection and Neglect-Induced Death|T-cell Receptor Signaling|T-cell receptor -> AP-1 signaling|T-cell receptor -> ATF/CREB signaling|T-cell receptor -> CREBBP signaling|T-cell receptor -> NF-kB signaling|T-cell receptor -> NFATC signaling|T-cell receptor -> STAT signaling|Th1 Cell Differentiation|Th17 Cell Differentiation|Th2 Cell Differentiation"	""	"prognosis|response to therapy"	"Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, adhesion and mobility of T-lymphocytes, thus ensuring correct delivery of effectors to the APC. ZAP70 is also required for TCR-CD247/CD3Z internalization and degradation through interaction with the E3 ubiquitin-protein ligase CBL and adapter proteins SLA and SLA2. Thus, ZAP70 regulates both T-cell activation switch on and switch off by modulating TCR expression at the T-cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative). Additionally, ZAP70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR)."	""	"TRUE"
"4479-14_2"	"SL000308"	"C1-Esterase Inhibitor"	"Plasma protease C1 inhibitor"	"11"	"57597387"	"57614853"	"SERPING1"	"710"	"P05155"	"Complement and Coagulation Cascades"	""	""	"Intrinsic Pathway of Fibrin Clot Formation|Platelet degranulation"	""	""	""	"Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein."	"29|322|412"	"TRUE"
"4480-59_2"	"SL000314"	"C3b"	"Complement C3b"	"19"	"6677704"	"6730562"	"C3"	"718"	"P01024"	"Complement Activation, Classical Pathway|Complement and Coagulation Cascades"	"Beta2 integrin cell surface interactions|Validated nuclear estrogen receptor alpha network|Validated nuclear estrogen receptor beta network"	""	"Activation of C3 and C5|Alternative complement activation|G alpha (i) signalling events|Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell|Peptide ligand-binding receptors|Regulation of Complement cascade"	"Alternative Complement Pathway|Classical Complement Pathway|Lectin-Induced Complement Pathway|T-cell-Independent B-cell Activation"	"IgG"	"efficacy"	"C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates."	""	"TRUE"
"4481-34_2"	"SL000316"	"C4"	"Complement C4"	"6"	"31969570"	"32111862"	"C4A|C4B"	"720|721"	"P0C0L4|P0C0L5"	"Complement Activation, Classical Pathway|SIDS Susceptibility Pathways"	""	""	"Activation of C3 and C5|Initial triggering of complement|Regulation of Complement cascade"	""	""	""	"Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.|Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens."	"205|235|256|372|447"	"TRUE"
"4482-66_2"	"SL000321"	"C5b, 6 Complex"	"Complement C5b-C6 complex"	"5|9"	"41142234|120952335"	"41261438|121050276"	"C5|C6"	"727|729"	"P01031|P13671"	"Complement Activation, Classical Pathway|Complement and Coagulation Cascades"	""	""	"Regulation of Complement cascade|Terminal pathway of complement"	"Alternative Complement Pathway|Classical Complement Pathway|Lectin-Induced Complement Pathway"	"eculizumab|IgG|"	""	"Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.|Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells."	""	"TRUE"
"4487-1_1"	"SL001691"	"FGF7"	"Fibroblast growth factor 7"	"15"	"49423096"	"49488775"	"FGF7"	"2252"	"P21781"	"Regulation of Actin Cytoskeleton"	"Glypican 3 network"	""	"Activated point mutants of FGFR2|Constitutive Signaling by Aberrant PI3K in Cancer|FGFR2b ligand binding and activation|FRS-mediated FGFR2 signaling|Negative regulation of FGFR2 signaling|PI-3K cascade:FGFR2|PI3K Cascade|PIP3 activates AKT signaling|Phospholipase C-mediated cascade, FGFR2|SHC-mediated cascade:FGFR2|Signaling by FGFR2 mutants|Signaling by FGFR4 mutants"	"FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling|FGFR -> RUNX2 signaling"	""	""	"Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation."	""	"TRUE"
"4490-65_2"	"SL005187"	"IL-3 Ra"	"Interleukin-3 receptor subunit alpha"	"X"	"1336616"	"1382689"	"IL3RA"	"3563"	"P26951"	"IL-3 Signaling Pathway"	"IL3-mediated signaling events"	""	"G beta:gamma signalling through PI3Kgamma|GPVI-mediated activation cascade|Interleukin receptor SHC signaling|Interleukin-3, 5 and GM-CSF signaling"	"IL3R -> STAT signaling"	"sargramostim|EPO/sargramostim|rituximab/sargramostim"	""	"This is a receptor for interleukin-3."	""	"TRUE"
"4491-4_2"	"SL005188"	"IL-5 Ra"	"Interleukin-5 receptor subunit alpha"	"3"	"3066326"	"3126613"	"IL5RA"	"3568"	"Q01344"	"IL-3 Signaling Pathway|IL-5 signaling pathway|Inflammatory Response Pathway"	"IL5-mediated signaling events"	""	"G beta:gamma signalling through PI3Kgamma|GPVI-mediated activation cascade|Interleukin receptor SHC signaling|Interleukin-3, 5 and GM-CSF signaling"	"IL5R -> SOX4 signaling|IL5R -> STAT signaling"	""	""	"This is the receptor for interleukin-5. The alpha chain binds to IL5."	"143"	"TRUE"
"4493-92_1"	"SL000470"	"IL-11"	"Interleukin-11"	"19"	"55364389"	"55370463"	"IL11"	"3589"	"P20809"	""	""	""	""	"IL11R -> STAT3 signaling"	""	"unspecified application"	"Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3."	""	"TRUE"
"4494-63_2"	"SL005184"	"IL-23"	"Interleukin-23"	"12|5"	"56334174|159314783"	"56340410|159330887"	"IL12B|IL23A"	"3593|51561"	"P29460|Q9NPF7"	"NA"	"NA"	"NA"	"NA"	"NA"	""	""	"Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.|Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis."	""	"TRUE"
"4495-33_2"	"SL017189"	"Kininogen, HMW"	"Kininogen-1"	"3"	"186717276"	"186743954"	"KNG1"	"3827"	"P01042"	"ACE Inhibitor Pathway|Complement and Coagulation Cascades"	"Beta2 integrin cell surface interactions|Syndecan-2-mediated signaling events"	""	"G alpha (i) signalling events|G alpha (q) signalling events|Intrinsic Pathway of Fibrin Clot Formation|Peptide ligand-binding receptors|Platelet degranulation"	"BDKRB1/2 -> interleukins production|BDKRB1/2 -> ion channels|BDKRB1/2 -> prostaglandin generation|BDKRB1/2 -> vasodilation|Coagulation Cascade"	""	""	"(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting."	"26|288"	"TRUE"
"4496-60_2"	"SL000522"	"MMP-12"	"Macrophage metalloelastase"	"11"	"102862736"	"102875034"	"MMP12"	"4321"	"P39900"	""	"Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling"	""	"Collagen degradation|Degradation of the extracellular matrix"	""	"marimastat"	"efficacy|unspecified application"	"May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3."	"107"	"TRUE"
"4498-62_2"	"SL003764"	"NCAM-120"	"Neural cell adhesion molecule 1, 120 kDa isoform"	"11"	"112961247"	"113278436"	"NCAM1"	"4684"	"P13591"	""	"FGF signaling pathway"	""	"ECM proteoglycans|Interferon gamma signaling|NCAM signaling for neurite out-growth|NCAM1 interactions|Signal transduction by L1"	"NCAM1 -> CREB/ELK-SRF/MYC signaling"	"BB-10901"	"efficacy|prognosis"	"This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc."	""	"TRUE"
"4499-21_1"	"SL000535"	"PDGF-AA"	"Platelet-derived growth factor subunit A"	"7"	"497258"	"520296"	"PDGFA"	"5154"	"P04085"	"Cytokines and Inflammatory Response|Focal Adhesion|Regulation of Actin Cytoskeleton"	"Ceramide signaling pathway|PDGF receptor signaling network"	""	"Constitutive Signaling by Aberrant PI3K in Cancer|Downstream signal transduction|Non-integrin membrane-ECM interactions|PIP3 activates AKT signaling|Platelet degranulation|Signaling by PDGF"	""	""	""	"Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity)."	""	"TRUE"
"4500-50_2"	"SL004363"	"SCGF-alpha"	"Stem Cell Growth Factor-alpha"	"19"	"50723329"	"50725718"	"CLEC11A"	"6320"	"Q9Y240"	""	""	""	""	""	""	""	"Stimulates the proliferation and differentiation of hematopoietic precursor cells from various lineages, including erythrocytes, lymphocytes, granulocytes and macrophages. Acts synergistically with other cytokines, including IL-3, GCSF, GMCSF and FLT3 ligand. Suppresses SCF-stimulated erythrocyte proliferation."	""	"TRUE"
"4533-76_2"	"SL012740"	"ATS15"	"A disintegrin and metalloproteinase with thrombospondin motifs 15"	"11"	"130448974"	"130476641"	"ADAMTS15"	"170689"	"Q8TE58"	""	""	""	"O-glycosylation of TSR domain-containing proteins"	""	""	""	"Zn(2+)"	""	"TRUE"
"4534-10_2"	"SL012822"	"BSSP4"	"Brain-specific serine protease 4"	"16"	"2852727"	"2858170"	"PRSS22"	"64063"	"Q9GZN4"	""	""	""	""	""	""	""	"Preferentially cleaves the synthetic substrate H-D-Leu-Thr-Arg-pNA compared to tosyl-Gly-Pro-Arg-pNA."	""	"TRUE"
"4535-50_2"	"SL008644"	"BST1"	"ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2"	"4"	"15702950"	"15738313"	"BST1"	"683"	"Q10588"	""	""	""	""	""	""	""	"Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth."	"18|62|151|195|375|382"	"TRUE"
"4540-11_2"	"SL009768"	"CBX5"	"Chromobox protein homolog 5"	"12"	"54230940"	"54280133"	"CBX5"	"23468"	"P45973"	""	"Aurora B signaling|E2F transcription factor network"	""	"Factors involved in megakaryocyte development and platelet production"	"Cleavage of Lamina in Apoptosis|Histone Phosphorylation|Histone Sumoylation|Histone and DNA Methylation|Nuclear Envelope"	""	""	"Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins."	""	"TRUE"
"4541-49_2"	"SL014092"	"CDON"	"Cell adhesion molecule-related/down-regulated by oncogenes"	"11"	"125955796"	"126063335"	"CDON"	"50937"	"Q4KMG0"	""	"Signaling events mediated by the Hedgehog family"	""	"CDO in myogenesis|Ligand-receptor interactions"	""	""	""	"Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity)."	"162"	"TRUE"
"4542-24_2"	"SL001896"	"Clusterin"	"Clusterin"	"8"	"27596917"	"27615031"	"CLU"	"1191"	"P10909"	""	"Validated targets of C-MYC transcriptional repression"	""	"Platelet degranulation"	""	""	"efficacy|unspecified application"	"Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation."	""	"TRUE"
"4543-65_2"	"SL014048"	"CONA1"	"Collagen alpha-1(XXIII) chain"	"5"	"178237618"	"178590555"	"COL23A1"	"91522"	"Q86Y22"	""	""	""	"Collagen biosynthesis and modifying enzymes|Collagen degradation|Integrin cell surface interactions"	""	"collagenase clostridium histolyticum"	"disease progression"	"Homotrimer."	""	"TRUE"
"4544-4_3"	"SL004708"	"CTAP-III"	"Connective tissue-activating peptide III"	"4"	"73987038"	"73988197"	"PPBP"	"5473"	"P02775"	""	""	""	"Chemokine receptors bind chemokines|G alpha (i) signalling events|Platelet degranulation"	""	""	""	"LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation."	""	"TRUE"
"4545-53_3"	"SL006197"	"DnaJ homolog"	"Mitochondrial import inner membrane translocase subunit TIM14"	"3"	"180983709"	"180989774"	"DNAJC19"	"131118"	"Q96DA6"	""	""	""	"Mitochondrial protein import"	"Mitochondrial Protein Transport"	""	""	"Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity)."	""	"TRUE"
"4546-27_3"	"SL008822"	"EMR2"	"EGF-like module-containing mucin-like hormone receptor-like 2"	"19"	"14732393"	"14778541"	"EMR2"	"30817"	"Q9UHX3"	""	""	""	""	""	""	""	"Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins."	"437"	"TRUE"
"4547-59_2"	"SL014071"	"FLRT1"	"Leucine-rich repeat transmembrane protein FLRT1"	"11"	"64103188"	"64119173"	"FLRT1"	"23769"	"Q9NZU1"	""	""	""	""	""	""	""	"Plays a role in fibroblast growth factor-mediated signaling cascades that lead to the activation of MAP kinases. Promotes neurite outgrowth via FGFR1-mediated activation of downstream MAP kinases. Promotes an increase both in neurite number and in neurite length. May play a role in cell-cell adhesion and cell guidance via its interaction with ADGRL1/LPHN1 and ADGRL3."	""	"TRUE"
"4548-4_2"	"SL005575"	"Fucosyltransferase 3"	"Galactoside 3(4)-L-fucosyltransferase"	"19"	"5842888"	"5851474"	"FUT3"	"2525"	"P21217"	""	""	"protein glycosylation"	""	"Lacto- and neolacto-type glycosphingolipid biosynthesis"	""	""	"May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination; Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links."	"51|190"	"TRUE"
"4549-78_2"	"SL014008"	"FUT5"	"Alpha-(1,3)-fucosyltransferase 5"	"19"	"5865826"	"5870540"	"FUT5"	"2527"	"Q11128"	""	""	"protein glycosylation"	""	"Lacto- and neolacto-type glycosphingolipid biosynthesis"	""	""	"May catalyze alpha-1,3 glycosidic linkages involved in the expression of VIM-2, Lewis X/SSEA-1 and sialyl Lewis X antigens."	""	"TRUE"
"4551-72_3"	"SL014094"	"GP114"	"Probable G-protein coupled receptor 114"	"16"	"57542421"	"57591681"	"GPR114"	"221188"	"Q8IZF4"	""	""	""	""	""	""	"NA"	"Orphan receptor."	""	"TRUE"
"4552-13_2"	"SL014129"	"H6ST1"	"Heparan-sulfate 6-O-sulfotransferase 1"	"2"	"128236716"	"128318577"	"HS6ST1"	"9394"	"O60243"	"NA"	"NA"	"NA"	"NA"	"NA"	""	""	"6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Critical for normal neuronal development where it may play a role in neuron branching. May also play a role in limb development. May prefer iduronic acid."	""	"TRUE"
"4553-65_3"	"SL014009"	"HDGR2"	"Hepatoma-derived growth factor-related protein 2"	"19"	"4472287"	"4502211"	"HDGFRP2"	"84717"	"Q7Z4V5"	""	""	""	""	""	""	""	"Involved in cellular growth control, through the regulation of cyclin D1 expression."	""	"TRUE"
"4556-10_2"	"SL013548"	"IL-34"	"Interleukin-34"	"16"	"70579895"	"70660682"	"IL34"	"146433"	"Q6ZMJ4"	""	""	""	""	""	""	""	"Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1."	""	"TRUE"
"4557-61_2"	"SL014111"	"KIRR3"	"Kin of IRRE-like protein 3"	"11"	"126423359"	"127003460"	"KIRREL3"	"84623"	"Q8IZU9"	""	""	""	"Nephrin interactions"	""	""	""	"Synaptic adhesion molecule required for the formation of target-specific synapses. Required for formation of target-specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation. Required for the coalescence of vomeronasal sensory neuron axons. May be involved in the hematopoietic supportive capacity of stroma cells; the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells."	""	"TRUE"
"4559-64_2"	"SL013969"	"KYNU"	"Kynureninase"	"2"	"142877498"	"143055832"	"KYNU"	"8942"	"Q16719"	""	""	""	""	""	""	""	"Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity."	"40"	"TRUE"
"4561-65_2"	"SL004299"	"Livin B"	"Baculoviral IAP repeat-containing protein 7 Isoform beta"	"20"	"63235883"	"63240507"	"BIRC7"	"79444"	"Q96CA5"	"Apoptosis Modulation and Signaling"	""	""	""	""	""	"diagnosis"	"Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing."	""	"TRUE"
"4562-1_2"	"SL012457"	"NXPH1"	"Neurexophilin-1"	"7"	"8433955"	"8752963"	"NXPH1"	"30010"	"P58417"	""	""	""	""	""	""	""	"May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors."	"210|365|422"	"TRUE"
"4563-61_2"	"SL012108"	"PLCG1"	"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1"	"20"	"41136960"	"41196801"	"PLCG1"	"5335"	"P19174"	"Angiogenesis|B Cell Receptor Signaling Pathway|EGF/EGFR Signaling Pathway|ErbB signaling pathway|IL-1 signaling pathway|Kit receptor signaling pathway|Leptin signaling pathway|Myometrial Relaxation and Contraction Pathways|RANKL/RANK Signaling Pathway|TCR Signaling Pathway|angiogenesis overview"	"Class I PI3K signaling events|E-cadherin signaling in keratinocytes|EGF receptor (ErbB1) signaling pathway|EPHA forward signaling|EPO signaling pathway|FGF signaling pathway|Fc-epsilon receptor I signaling in mast cells|LPA receptor mediated events|N-cadherin signaling events|Nephrin/Neph1 signaling in the kidney podocyte|Netrin-mediated signaling events|Neurotrophic factor-mediated Trk receptor signaling|Nongenotropic Androgen signaling|PDGFR-alpha signaling pathway|PDGFR-beta signaling pathway|Regulation of CDC42 activity|S1P1 pathway|S1P4 pathway|Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)|Signaling events mediated by VEGFR1 and VEGFR2|Signaling events mediated by focal adhesion kinase|TCR signaling in naïve CD4+ T cells|TCR signaling in naïve CD8+ T cells|Trk receptor signaling mediated by PI3K and PLC-gamma|VEGFR1 specific signals"	""	"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers|Constitutive Signaling by EGFRvIII|Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants|DAG and IP3 signaling|DAP12 signaling|Downstream signal transduction|EGFR interacts with phospholipase C-gamma|FCERI mediated Ca+2 mobilization|FCERI mediated MAPK activation|Frs2-mediated activation|Generation of second messenger molecules|ISG15 antiviral mechanism|PECAM1 interactions|PLC-gamma1 signalling|PLCG1 events in ERBB2 signaling|Phospholipase C-mediated cascade, FGFR2|Phospholipase C-mediated cascade, FGFR3|Phospholipase C-mediated cascade, FGFR4|Phospholipase C-mediated cascade: FGFR1|Role of phospholipids in phagocytosis|Role of second messengers in netrin-1 signaling|Signaling by FGFR1 fusion mutants|Signaling by FGFR1 mutants|Signaling by FGFR2 mutants|Signaling by FGFR3 mutants|Signaling by FGFR4 mutants|Synthesis of IP3 and IP4 in the cytosol|VEGFR2 mediated cell proliferation"	"AngiopoietinR -> AP-1 signaling|CD2 -> NFATC1 signaling|CD8+ T-cell Activation|CRH -> synthesis of corticosteroids|Central T-cell Tolerance|DRD2/4 -> membrane transport|DopamineR2 -> AP-1/CREB/ELK-SRF signaling|EDG2 -> ELK-SRF signaling|EGFR -> AP-1/ATF2 signaling|EGFR -> AP-1/CREB/ELK-SRF/MYC signaling|EGFR -> NCOR2 signaling|EGFR -> SMAD1 signaling|EGFR/ERBB2 -> HIF1A signaling|EGFR/ERBB2 -> TP53 signaling|EPHB -> NMDA receptor activation|ERBB2/3 -> EP300/ETS/ETV/SP1 signaling|ErythropoietinR -> AP-1/CREB/MYC signaling|FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling|FGFR -> RUNX2 signaling|FcIgER -> ELK-SRF signaling|FcIgER -> NFATC1 signaling|FibronectinR -> AP-1/ELK-SRF/SREBF signaling|GDNF -> HSF1 signaling|GFs/TNF -> ion channels|HGFR -> AP-1/CREB/MYC signaling|ICAM1 -> AP-1/CREB/ELK-SRF signaling|KIT -> MITF signaling|Model of T-cell Maturation|NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling|NTRK1/2/3 -> acetylcholine production|Natural Killer Cell Activation|Natural Killer Cell Activation through ITAM-Containing Receptors|Natural Killer Cell Activation through ITSM-Containing Receptors|Natural Killer Cell Inhibitory Receptor Signaling|Nociception-related DRD2 expression targets|PDGFR -> AP-1/MYC signaling|PTPRC -> BCL6 signaling|Peripheral T-cell Tolerance Overview|Regulation of calcium flux|Regulation of potassium flux|Regulatory T-cell Differentiation|SELE -> ELK-SRF signaling|Summarized nociception-related expression targets|T-cell Receptor Signaling|T-cell receptor -> AP-1 signaling|T-cell receptor -> ATF/CREB signaling|T-cell receptor -> CREBBP signaling|T-cell receptor -> NF-kB signaling|T-cell receptor -> NFATC signaling|T-cell-Independent B-cell Activation|Th1 Cell Differentiation|Th17 Cell Differentiation|Th2 Cell Differentiation|ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling|UrokinaseR -> ELK-SRF signaling|V(D)J Recombination Activation|VEGFR -> AP-1/CREB/MYC signaling|VEGFR -> ATF/CREB/ELK-SRF signaling|VEGFR -> NFATC signaling"	""	""	"Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration."	""	"TRUE"
"4564-2_2"	"SL006406"	"PLXC1"	"Plexin-C1"	"12"	"94148723"	"94307675"	"PLXNC1"	"10154"	"O60486"	""	""	""	"Other semaphorin interactions"	""	""	""	"Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity)."	"148|261"	"TRUE"
"4566-24_3"	"SL013989"	"RSPO2"	"R-spondin-2"	"8"	"107899316"	"108083648"	"RSPO2"	"340419"	"Q6UXX9"	""	""	""	"regulation of FZD by ubiquitination"	""	""	""	"Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors."	""	"TRUE"
"4567-82_2"	"SL014468"	"SH21A"	"SH2 domain-containing protein 1A"	"X"	"124346344"	"124373155"	"SH2D1A"	"4068"	"O60880"	""	"Direct p53 effectors"	""	""	"Natural Killer Cell Activation through ITSM-Containing Receptors"	""	""	"Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3."	""	"TRUE"
"4568-17_2"	"SL014070"	"SLIK5"	"SLIT and NTRK-like protein 5"	"13"	"87672615"	"87696272"	"SLITRK5"	"26050"	"O94991"	""	""	""	""	""	""	""	"Suppresses neurite outgrowth."	""	"TRUE"
"4569-52_2"	"SL014091"	"SORC2"	"VPS10 domain-containing receptor SorCS2"	"4"	"7192538"	"7742836"	"SORCS2"	"57537"	"Q96PQ0"	""	""	""	""	""	""	""	"Membrane"	""	"TRUE"
"4588-1_2"	"SL011499"	"PH"	"Pancreatic hormone"	"17"	"43940804"	"43942468"	"PPY"	"5539"	"P01298"	""	""	""	"G alpha (i) signalling events|Peptide ligand-binding receptors"	""	""	""	"Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions."	""	"TRUE"
"4593-11_1"	"SL011508"	"PACAP-27"	"Pituitary adenylate cyclase-activating polypeptide 27"	"18"	"904943"	"912172"	"ADCYAP1"	"116"	"P18509"	"NA"	"NA"	"NA"	"NA"	"NA"	""	""	"Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway."	""	"TRUE"
"4594-22_2"	"SL011498"	"PACAP-38"	"Pituitary adenylate cyclase-activating polypeptide 38"	"18"	"904943"	"912172"	"ADCYAP1"	"116"	"P18509"	"NA"	"NA"	"NA"	"NA"	"NA"	""	""	"Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway."	""	"TRUE"
"4673-13_2"	"SL000087"	"IL-6"	"Interleukin-6"	"7"	"22725884"	"22732002"	"IL6"	"3569"	"P05231"	"Adipogenesis|Cytokines and Inflammatory Response|Folate Metabolism|IL-6 signaling pathway|Myometrial Relaxation and Contraction Pathways|Regulation of toll-like receptor signaling pathway|SIDS Susceptibility Pathways|Selenium Pathway|Senescence and Autophagy|TCR Signaling Pathway|TNF alpha Signaling Pathway|TWEAK Signaling Pathway|Toll-like receptor signaling pathway|Vitamin B12 Metabolism"	"AP-1 transcription factor network|ATF-2 transcription factor network|Glucocorticoid receptor regulatory network|IL23-mediated signaling events|IL27-mediated signaling events|IL6-mediated signaling events|LPA receptor mediated events|SHP2 signaling|Validated transcriptional targets of AP1 family members Fra1 and Fra2|amb2 Integrin signaling"	""	"ERK1 activation|ERK2 activation|Interleukin-6 signaling|Senescence-Associated Secretory Phenotype (SASP)"	"\"Dectin-2 (CLEC6A), Mincle (CLEC4E), and BDCA2 (CLEC4C) Signaling\"|ADRA1A -> IL6 production|BDKRB1/2 -> interleukins production|CNR1/2 -> IL1B/2/4/6/10 production|HTR1 -> IL6 production|HTR7 -> IL6 production|IL6R -> CEBP/ELK-SRF signaling|IL6R -> STAT signaling|IL6ST -> STAT5B signaling|Leptin -> CD25/IL6/IL10 production|Model of T-cell Maturation|Nociception-related IL1B expression targets|Nociception-related IL6 expression targets|PTGER2/3 -> inflammation-related expression targets|PTGIR -> IL6 production|Summarized nociception-related expression targets|TACR1 -> TNF/IL6/IL8 production|TLR4 Signaling in Leukocytes|Th17 Cell Differentiation|Toll-like Receptors Act through MYD88-TIRAP Signaling"	"tocilizumab|siltuximab"	"diagnosis|disease progression|efficacy|prognosis|response to therapy|safety|unspecified application"	"Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation."	""	"TRUE"
"4693-72_2"	"SL008085"	"3HIDH"	"3-hydroxyisobutyrate dehydrogenase, mitochondrial"	"7"	"27525442"	"27662995"	"HIBADH"	"11112"	"P31937"	""	""	"L-valine degradation"	"Branched-chain amino acid catabolism"	""	""	""	"3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH."	""	"TRUE"
"4696-2_2"	"SL001774"	"FABP"	"Fatty acid-binding protein, heart"	"1"	"31365625"	"31376850"	"FABP3"	"2170"	"P05413"	"NA"	"NA"	"NA"	"NA"	"NA"	""	"diagnosis|unspecified application"	"FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters."	""	"TRUE"
"4697-59_2"	"SL001726"	"GM-CSF"	"Granulocyte-macrophage colony-stimulating factor"	"5"	"132073790"	"132076170"	"CSF2"	"1437"	"P04141"	"Cytokines and Inflammatory Response"	"AP-1 transcription factor network|Alpha9 beta1 integrin signaling events|Calcineurin-regulated NFAT-dependent transcription in lymphocytes|Calcium signaling in the CD4+ TCR pathway|GMCSF-mediated signaling events|Glucocorticoid receptor regulatory network|Regulation of retinoblastoma protein|Syndecan-2-mediated signaling events"	""	"G beta:gamma signalling through PI3Kgamma|GPVI-mediated activation cascade|Interleukin receptor SHC signaling|Interleukin-3, 5 and GM-CSF signaling"	"CSF2R -> NF-kB signaling|CSF2R -> STAT signaling|Natural Killer Cell Activation through C-type Lectin-like Receptors|Natural Killer Cell Activation through ITAM-Containing Receptors|Natural Killer Cell Activation through ITSM-Containing Receptors"	""	"efficacy|prognosis|unspecified application"	"Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes."	""	"TRUE"
"4703-87_2"	"SL000597"	"TNF-b"	"Lymphotoxin-alpha"	"6"	"31562799"	"31613772"	"LTA"	"4049"	"P01374"	"Apoptosis"	"IL2 signaling events mediated by STAT5|IL4-mediated signaling events"	""	""	"CD8+ T-cell Activation|Cell Death Mediated by Cytotoxic Cells|TNFR -> AP-1/ATF/TP53 signaling|TNFR -> CREB/ELK-SRF signaling|TNFR -> NF-kB signaling|TNFRSF1A -> AP-1/ATF/TP53 signaling|TNFRSF1A -> CREB/ELK-SRF signaling|TNFRSF1A -> STAT signaling|Th1 Cell Differentiation"	""	"prognosis|safety"	"Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo."	""	"TRUE"
"4706-17_2"	"SL010830"	"41"	"Protein 4.1"	"1"	"28887091"	"29120046"	"EPB41"	"2035"	"P11171"	""	"Syndecan-2-mediated signaling events"	""	""	"Adherens Junction Assembly (Cadherins)|Tight Junction Assembly (Claudins)|Tight Junction Assembly (JAMs)|Tight Junction Assembly (Occludin)"	""	""	"Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes."	""	"TRUE"
"4708-3_2"	"SL004253"	"17-beta-HSD 1"	"Estradiol 17-beta-dehydrogenase 1"	"17"	"42549214"	"42555213"	"HSD17B1"	"3292"	"P14061"	"Steroid Biosynthesis"	""	"estrogen biosynthesis"	"Estrogen biosynthesis|The canonical retinoid cycle in rods (twilight vision)"	""	""	"diagnosis|unspecified application"	"Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH."	""	"TRUE"
"4712-28_2"	"SL005361"	"Apo D"	"Apolipoprotein D"	"3"	"195568702"	"195584205"	"APOD"	"347"	"P05090"	""	""	""	"Transport of fatty acids"	""	""	"safety"	"APOD occurs in the macromolecular complex with lecithin-cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts."	""	"TRUE"
"4717-55_2"	"SL000479"	"IL-3"	"Interleukin-3"	"5"	"132060529"	"132063204"	"IL3"	"3562"	"P08700"	"IL-3 Signaling Pathway|Senescence and Autophagy"	"Calcineurin-regulated NFAT-dependent transcription in lymphocytes|Calcium signaling in the CD4+ TCR pathway|IL3-mediated signaling events"	""	"G beta:gamma signalling through PI3Kgamma|GPVI-mediated activation cascade|Interleukin receptor SHC signaling|Interleukin-3, 5 and GM-CSF signaling"	"IL3R -> STAT signaling|Model of T-cell Maturation"	""	""	"Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages."	""	"TRUE"
"4718-5_2"	"SL007869"	"PPIB"	"Peptidyl-prolyl cis-trans isomerase B"	"15"	"64155812"	"64163205"	"PPIB"	"5479"	"P23284"	"Epithelium TarBase|Leukocyte TarBase|Lymphocyte TarBase|Muscle cell TarBase|Prolactin Signaling Pathway"	"Syndecan-1-mediated signaling events"	""	"Collagen biosynthesis and modifying enzymes"	""	""	""	"PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides."	""	"TRUE"
"4719-58_2"	"SL003524"	"Protein disulfide isomerase A3"	"Protein disulfide-isomerase A3"	"15"	"43746392"	"43773279"	"PDIA3"	"2923"	"P30101"	""	""	""	"Antigen Presentation: Folding, assembly and peptide loading of class I MHC|Calnexin/calreticulin cycle|ER-Phagosome pathway"	"MHC1-Mediated Antigen Presentation|Presentation of Endogenous Peptide Antigen"	""	"diagnosis"	"Catalyzes the rearrangement of -S-S- bonds in proteins."	""	"TRUE"
"4721-54_2"	"SL006119"	"TFF3"	"Trefoil factor 3"	"21"	"42311667"	"42315651"	"TFF3"	"7033"	"Q07654"	""	"HIF-1-alpha transcription factor network|IL4-mediated signaling events"	""	""	""	""	"diagnosis|unspecified application"	"Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen)."	"368"	"TRUE"
"4763-31_3"	"SL004742"	"Afamin"	"Afamin"	"4"	"73481683"	"73504001"	"AFM"	"173"	"P43652"	""	""	""	""	""	""	""	"Vitamin E binding protein. May transport vitamin E in body fluids under conditions where the lipoprotein system is not sufficient. May be involved in the regulation and transport of vitamin E at the blood-brain barrier."	"384"	"TRUE"
"4769-10_3"	"SL008590"	"Olfactomedin-4"	"Olfactomedin-4"	"13"	"53028759"	"53052057"	"OLFM4"	"10562"	"Q6UX06"	""	""	""	""	""	""	""	"May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin."	""	"TRUE"
"4771-10_3"	"SL012754"	"ASM3A"	"Acid sphingomyelinase-like phosphodiesterase 3a"	"6"	"122789049"	"122809720"	"SMPDL3A"	"10924"	"Q92484"	""	""	""	""	""	""	""	"Secreted"	"232"	"TRUE"
"4774-62_3"	"SL016129"	"FAM107B"	"Protein FAM107B"	"10"	"14518557"	"14774897"	"FAM107B"	"83641"	"Q9H098"	""	""	""	""	""	""	""	"alternative splicing"	""	"TRUE"
"4775-34_3"	"SL005572"	"Gelsolin"	"Gelsolin"	"9"	"121207794"	"121332843"	"GSN"	"2934"	"P06396"	"Regulation of Actin Cytoskeleton|Senescence and Autophagy"	"Caspase Cascade in Apoptosis|Coregulation of Androgen receptor activity|EGF receptor (ErbB1) signaling pathway|N-cadherin signaling events|Osteopontin-mediated events"	""	"Amyloids|Caspase-mediated cleavage of cytoskeletal proteins"	"Actin Cytoskeleton Assembly|Apoptosis"	""	"disease progression|efficacy"	"Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis."	""	"TRUE"
"4785-30_3"	"SL000347"	"CBG"	"Corticosteroid-binding globulin"	"14"	"94304248"	"94323394"	"SERPINA6"	"866"	"P08185"	""	""	""	""	""	""	""	"Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species."	""	"TRUE"
"4786-58_3"	"SL007871"	"Cytidylate kinase"	"UMP-CMP kinase"	"1"	"47333797"	"47378839"	"CMPK1"	"51727"	"P30085"	""	""	""	""	""	""	""	"Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity."	"82"	"TRUE"
"4792-51_2"	"SL016148"	"C34 gp41 HIV Fragment"	"gp41 C34 peptide, HIV"	"NA"	"NA"	"NA"	"Human-virus"	"NA"	"Q70626"	""	""	""	""	""	""	""	"Envelope glycoprotein gp160: Oligomerizes in the host endoplasmic reticulum into predominantly trimers. In a second time, gp160 transits in the host Golgi, where glycosylation is completed. The precursor is then proteolytically cleaved in the trans-Golgi and thereby activated by cellular furin or furin-like proteases to produce gp120 and gp41."	"137|159|205|350"	"TRUE"
"4801-13_3"	"SL007153"	"PERL"	"Lactoperoxidase"	"17"	"58218548"	"58268518"	"LPO"	"4025"	"P22079"	""	""	""	""	""	""	""	"Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN) (By similarity). May contribute to airway host defense against infection."	""	"TRUE"
"4807-13_3"	"SL008072"	"CO8A1"	"Collagen alpha-1(VIII) chain"	"3"	"99638475"	"99799226"	"COL8A1"	"1295"	"P27658"	""	"Integrins in angiogenesis|Syndecan-1-mediated signaling events"	""	"Assembly of collagen fibrils and other multimeric structures|Collagen biosynthesis and modifying enzymes|Collagen degradation|Integrin cell surface interactions"	""	"collagenase clostridium histolyticum"	""	"Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis."	""	"TRUE"
"4811-33_3"	"SL004739"	"ITI heavy chain H4"	"Inter-alpha-trypsin inhibitor heavy chain H4"	"3"	"52812975"	"52831479"	"ITIH4"	"3700"	"Q14624"	""	""	""	""	""	""	""	"Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration."	""	"TRUE"
"4815-25_3"	"SL016128"	"TXD12"	"Thioredoxin domain-containing protein 12"	"1"	"52020131"	"52056171"	"TXNDC12"	"51060"	"O95881"	""	""	""	""	""	""	""	"Possesses significant protein thiol-disulfide oxidase activity."	"66|91|95|334"	"TRUE"
"4829-43_6"	"SL001737"	"STRATIFIN"	"14-3-3 protein sigma"	"1"	"26863138"	"26864457"	"SFN"	"2810"	"P31947"	"Calcium Regulation in the Cardiac Cell|DNA damage response|Myometrial Relaxation and Contraction Pathways|miRNA regulation of DNA Damage Response"	"Class I PI3K signaling events mediated by Akt|Direct p53 effectors|ErbB1 downstream signaling|FoxO family signaling|Glucocorticoid receptor regulatory network|Insulin-mediated glucose transport|LKB1 signaling events|PDGFR-beta signaling pathway|Regulation of nuclear beta catenin signaling and target gene transcription|Role of Calcineurin-dependent NFAT signaling in lymphocytes|Trk receptor signaling mediated by PI3K and PLC-gamma|Validated transcriptional targets of deltaNp63 isoforms|a6b1 and a6b4 Integrin signaling|mTOR signaling pathway|p38 signaling mediated by MAPKAP kinases|p73 transcription factor network"	""	"Activation of BAD and translocation to mitochondria|Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex|RHO GTPases activate PKNs|TP53 Regulates Metabolic Genes|Translocation of GLUT4 to the plasma membrane"	"Cell Cycle"	""	"prognosis"	"Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53."	""	"TRUE"
"4831-4_2"	"SL002823"	"sL-Selectin"	"L-Selectin"	"1"	"169690667"	"169711698"	"SELL"	"6402"	"P14151"	""	""	""	"Cell surface interactions at the vascular wall|Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"	"Leukocyte Adhesion to Endothelial Cell"	""	"efficacy"	"Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia."	"163"	"TRUE"
"4832-75_2"	"SL004156"	"TRAIL R1"	"Tumor necrosis factor receptor superfamily member 10A"	"8"	"23190452"	"23225126"	"TNFRSF10A"	"8797"	"O00220"	"Apoptosis Modulation and Signaling|Lymphocyte TarBase"	"Caspase Cascade in Apoptosis|Direct p53 effectors|TRAIL signaling pathway"	""	"CASP8 activity is inhibited|Dimerization of procaspase-8|Ligand-dependent caspase activation|RIPK1-mediated regulated necrosis|Regulation by c-FLIP|TRAIL signaling"	"Apoptosis|Cell Death Mediated by Cytotoxic Cells|Peripheral T-cell Tolerance Overview|TNFR -> AP-1/ATF/TP53 signaling|TNFR -> CREB/ELK-SRF signaling|TNFR -> NF-kB signaling"	"trm-1"	"diagnosis"	"Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B."	""	"TRUE"
"4834-61_2"	"SL002654"	"Epithelial cell kinase"	"Ephrin type-A receptor 2"	"1"	"16124337"	"16156087"	"EPHA2"	"1969"	"P29317"	""	"Arf6 signaling events|Direct p53 effectors|EPHA forward signaling|EPHA2 forward signaling|EphrinA-EPHA pathway|Stabilization and expansion of the E-cadherin adherens junction"	""	"EPH-Ephrin signaling|EPH-ephrin mediated repulsion of cells|EPHA-mediated growth cone collapse"	""	"dasatinib|regorafenib|dasatinib/dexamethasone/vincristine"	"disease progression"	"Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis."	""	"TRUE"
"4840-73_1"	"SL001729"	"G-CSF"	"Granulocyte colony-stimulating factor"	"17"	"40015361"	"40017813"	"CSF3"	"1440"	"P09919"	"Cytokines and Inflammatory Response"	""	""	""	"CSF3R -> STAT signaling|Nociception-related IL1B expression targets"	"filgrastim"	"diagnosis"	"Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes."	"54"	"TRUE"
"4842-62_2"	"SL000070"	"Glypican 3"	"Glypican-3"	"X"	"133535745"	"133985895"	"GPC3"	"2719"	"P51654"	""	"Glypican 3 network|Glypican pathway"	""	"A tetrasaccharide linker sequence is required for GAG synthesis|Defective B3GAT3 causes JDSSDHD|Defective B4GALT7 causes EDS, progeroid type|Defective EXT1 causes exostoses 1, TRPS2 and CHDS|Defective EXT2 causes exostoses 2|HS-GAG biosynthesis|HS-GAG degradation|Retinoid metabolism and transport"	""	""	"diagnosis|prognosis"	"Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition."	""	"TRUE"
"4851-25_1"	"SL000125"	"IL-1a"	"Interleukin-1 alpha"	"2"	"112773915"	"112784590"	"IL1A"	"3552"	"P01583"	"Cytokines and Inflammatory Response|FAS pathway and Stress induction of HSP regulation|Hypertrophy Model|IL-1 signaling pathway|MAPK signaling pathway|Senescence and Autophagy|TCR Signaling Pathway"	"IL1-mediated signaling events|Validated transcriptional targets of deltaNp63 isoforms|a6b1 and a6b4 Integrin signaling"	""	"Interleukin-1 processing|Interleukin-1 signaling|Senescence-Associated Secretory Phenotype (SASP)"	"IL1R -> NF-kB signaling|IL1R -> STAT3 signaling"	""	"efficacy|prognosis|unspecified application"	"Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells."	""	"TRUE"
"4859-6_1"	"SL004080"	"BMPR1A"	"Bone morphogenetic protein receptor type-1A"	"10"	"86756650"	"86932838"	"BMPR1A"	"657"	"P36894"	"BMP signalling and regulation|Endochondral Ossification|Heart Development|Integrated Breast Cancer Pathway"	"BMP receptor signaling"	""	"Signaling by BMP"	"ActivinR/BMPR -> SMAD1/5/9 signaling"	""	"diagnosis|unspecified application"	"On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6."	""	"TRUE"
"4862-63_1"	"SL004133"	"BMP RII"	"Bone morphogenetic protein receptor type-2"	"2"	"202376936"	"202567751"	"BMPR2"	"659"	"Q13873"	"BMP signalling and regulation|Heart Development|Integrated Breast Cancer Pathway"	"ALK1 signaling events|ALK2 signaling events|BMP receptor signaling"	""	"Signaling by BMP"	"ActivinR/BMPR -> SMAD1/5/9 signaling|TGFBR/BMPR -> SMAD2/3 signaling"	""	"diagnosis|unspecified application"	"On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6."	""	"TRUE"
"4866-59_2"	"SL004160"	"TrkB"	"BDNF/NT-3 growth factors receptor"	"9"	"84668551"	"85027070"	"NTRK2"	"4915"	"Q16620"	""	"Neurotrophic factor-mediated Trk receptor signaling|Posttranslational regulation of adherens junction stability and dissassembly|SHP2 signaling"	""	"NGF-independant TRKA activation"	"GFs/TNF -> ion channels|NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling|NTRK -> FOXO/MYCN signaling|NTRK1/2/3 -> acetylcholine production|Regulation of calcium flux"	"cabozantinib|cabozantinib/erlotinib"	"diagnosis|disease progression|response to therapy"	"Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia."	""	"TRUE"
"4867-15_2"	"SL003310"	"VEGF121"	"Vascular endothelial growth factor A, isoform 121"	"6"	"43770184"	"43786487"	"VEGFA"	"7422"	"P15692"	"Angiogenesis|Endochondral Ossification|Heart Development|Hypertrophy Model|Integrated Breast Cancer Pathway|angiogenesis overview"	"Alpha9 beta1 integrin signaling events|Beta1 integrin cell surface interactions|Beta3 integrin cell surface interactions|Glypican 1 network|HIF-1-alpha transcription factor network|HIF-2-alpha transcription factor network|Integrins in angiogenesis|Plexin-D1 Signaling|S1P1 pathway|S1P3 pathway|SHP2 signaling|Signaling events mediated by TCPTP|Signaling events mediated by VEGFR1 and VEGFR2|VEGF and VEGFR signaling network|VEGFR1 specific signals"	""	"EPHA-mediated growth cone collapse|Platelet degranulation|Regulation of gene expression by Hypoxia-inducible Factor|VEGF binds to VEGFR leading to receptor dimerization|VEGF ligand-receptor interactions|VEGFA-VEGFR2 Pathway|VEGFR2 mediated cell proliferation"	"Nociception-related CCR1 expression targets|Nociception-related IL1B expression targets|Summarized nociception-related expression targets|VEGFR -> AP-1/CREB/MYC signaling|VEGFR -> ATF/CREB/ELK-SRF signaling|VEGFR -> CTNNB signaling|VEGFR -> CTNND signaling|VEGFR -> FOXO3A signaling|VEGFR -> NFATC signaling|VEGFR -> STAT signaling"	"dalteparin|bevacizumab|ranibizumab|aflibercept|bevacizumab/erlotinib|bevacizumab/sorafenib|bevacizumab/5-fluorouracil|bevacizumab/temozolomide|bevacizumab/irinotecan|bevacizumab/carmustine/lomustine|bevacizumab/paclitaxel|bevacizumab/irinotecan/oxaliplatin|aflibercept/irinotecan|bevacizumab/capecitabine/oxaliplatin|bevacizumab/panitumumab|bevacizumab/cetuximab|bevacizumab/pemetrexed|bevacizumab/gemcitabine|bevacizumab/capecitabine/irinotecan/oxaliplatin|bevacizumab/capecitabine|bevacizumab/paclitaxel/topotecan|bevacizumab/oxaliplatin|bevacizumab/docetaxel|pegaptanib"	"diagnosis|efficacy|prognosis|safety|unspecified application"	"Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth."	""	"TRUE"
"4874-3_1"	"SL000003"	"Angiogenin"	"Angiogenin"	"14"	"20684177"	"20698971"	"ANG"	"283"	"P03950"	""	""	""	""	""	""	"response to therapy"	"Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo."	"104|131|286|324"	"TRUE"
"4875-73_1"	"SL003362"	"C3d"	"Complement C3d fragment"	"19"	"6677704"	"6730562"	"C3"	"718"	"P01024"	"NA"	"NA"	"NA"	"NA"	"NA"	"IgG"	"efficacy"	"C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates."	""	"TRUE"
"4876-32_1"	"SL000357"	"Coagulation Factor IX"	"Coagulation factor IX"	"X"	"139530758"	"139563458"	"F9"	"2158"	"P00740"	"Blood Clotting Cascade|Complement and Coagulation Cascades"	""	""	"Extrinsic Pathway of Fibrin Clot Formation|Gamma-carboxylation of protein precursors|Intrinsic Pathway of Fibrin Clot Formation|Removal of aminoterminal propeptides from gamma-carboxylated proteins|Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus"	"Coagulation Cascade|Vitamin K metabolism"	"moroctocog alfa|activated recombinant human factor VII"	""	"Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa."	""	"TRUE"
"4878-3_1"	"SL000360"	"Coagulation Factor X"	"Coagulation Factor X"	"13"	"113122814"	"113149529"	"F10"	"2159"	"P00742"	"Blood Clotting Cascade|Complement and Coagulation Cascades"	"Beta2 integrin cell surface interactions"	""	"Common Pathway of Fibrin Clot Formation|Extrinsic Pathway of Fibrin Clot Formation|Gamma-carboxylation of protein precursors|Intrinsic Pathway of Fibrin Clot Formation|Removal of aminoterminal propeptides from gamma-carboxylated proteins|Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus"	"Coagulation Cascade|Vitamin K metabolism"	"dalteparin|heparin|enoxaparin|rivaroxaban|deligoparin|idraparinux|tifacogin|RPR 120844|RPR 208566|DPC 423|nematode anticoagulant protein c2|apixaban|activated recombinant human factor VII|F8|edoxaban|F9|fondaparinux"	"efficacy"	"Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting."	""	"TRUE"
"4880-21_1"	"SL007756"	"GDF2"	"Growth/differentiation factor 2"	"10"	"47322490"	"47326270"	"GDF2"	"2658"	"Q9UK05"	""	"ALK1 signaling events"	""	""	""	""	""	"Potent circulating inhibitor of angiogenesis. Could be involved in bone formation. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG."	""	"TRUE"
"4883-56_2"	"SL000021"	"Insulin"	"Insulin"	"11"	"2159779"	"2161341"	"INS"	"3630"	"P01308"	"Adipogenesis|Folate Metabolism|SREBP signalling|Selenium Pathway|Senescence and Autophagy|Vitamin B12 Metabolism"	"ATF-2 transcription factor network|Arf6 trafficking events|FOXA1 transcription factor network|FOXA2 and FOXA3 transcription factor networks|Insulin Pathway|Insulin-mediated glucose transport|Signaling events mediated by PTP1B|Signaling events mediated by TCPTP"	""	"IRS activation|Insulin processing|Insulin receptor recycling|Regulation of gene expression in beta cells|Regulation of insulin secretion|SHC activation|Signal attenuation|Signaling by Insulin receptor|Synthesis, secretion, and deacylation of Ghrelin"	"Glutathione metabolism|IGF1R -> CEBPA/FOXO1A signaling|IGF1R -> ELK-SRF/HIF1A/MYC/SREBF signaling|IGF1R -> MEF/MYOD/MYOG signaling|IGF1R -> STAT signaling|InsulinR -> CTNNB/FOXA/FOXO signaling|InsulinR -> ELK-SRF/SREBF signaling|InsulinR -> STAT signaling"	""	"diagnosis|disease progression|efficacy|prognosis|safety|unspecified application"	"Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver."	""	"TRUE"
"4886-3_1"	"SL000516"	"MCP-3"	"C-C motif chemokine 7"	"17"	"34270221"	"34272242"	"CCL7"	"6354"	"P80098"	""	""	""	"Chemokine receptors bind chemokines"	"CCR1 -> STAT signaling|CCR2/5 -> STAT signaling|CCR5 -> TP53 signaling|Nociception-related CCR1 expression targets|Summarized nociception-related expression targets"	""	""	"Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3."	"53"	"TRUE"
"4889-82_1"	"SL009951"	"WNT7A"	"Protein Wnt-7a"	"3"	"13816258"	"13880121"	"WNT7A"	"7476"	"O00755"	"DNA damage response (only ATM dependent)|Wnt Signaling Pathway|Wnt Signaling Pathway and Pluripotency"	"Wnt signaling network"	""	"Class B/2 (Secretin family receptors)|WNT ligand biogenesis and trafficking"	""	""	""	"Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Signaling by Wnt-7a allows sexually dimorphic development of the mullerian ducts (By similarity)."	""	"TRUE"
"4890-10_1"	"SL003461"	"ACTH"	"Corticotropin"	"2"	"25160853"	"25168903"	"POMC"	"5443"	"P01189"	""	"Glucocorticoid receptor regulatory network|Syndecan-3-mediated signaling events"	""	"Androgen biosynthesis|Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)|Endogenous sterols|G alpha (i) signalling events|G alpha (s) signalling events|G-protein activation|Glucocorticoid biosynthesis|Opioid Signalling|Peptide hormone biosynthesis|Peptide ligand-binding receptors"	"CRH -> synthesis of corticosteroids|GALR1/2/3 -> POMC/NPY production|NPY1R -> CRH/POMC production|Nociception-related IL1B expression targets|OpioidR -> CREB/ELK-SRF/STAT3 signaling|Summarized nociception-related expression targets"	""	"diagnosis|efficacy|unspecified application"	"ACTH stimulates the adrenal glands to release cortisol."	""	"TRUE"
"4891-50_1"	"SL000433"	"Glucagon"	"Glucagon"	"2"	"162142873"	"162152404"	"GCG"	"2641"	"P01275"	""	"FOXA1 transcription factor network"	""	"G alpha (q) signalling events|G alpha (s) signalling events|Glucagon signaling in metabolic regulation|Glucagon-like Peptide-1 (GLP1) regulates insulin secretion|Glucagon-type ligand receptors|Synthesis, secretion, and deacylation of Ghrelin|Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)"	"GlucagonR -> CREB/ELK-SRF/SP1 signaling"	"liraglutide|exenatide"	"efficacy"	"Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes."	""	"TRUE"
"4900-8_1"	"SL000313"	"C3a"	"C3a anaphylatoxin"	"19"	"6677704"	"6730562"	"C3"	"718"	"P01024"	"Complement Activation, Classical Pathway|Complement and Coagulation Cascades"	"Beta2 integrin cell surface interactions|Validated nuclear estrogen receptor alpha network|Validated nuclear estrogen receptor beta network"	""	"Activation of C3 and C5|Alternative complement activation|G alpha (i) signalling events|Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell|Peptide ligand-binding receptors|Regulation of Complement cascade"	"Alternative Complement Pathway|Classical Complement Pathway|Lectin-Induced Complement Pathway|T-cell-Independent B-cell Activation"	"IgG"	"efficacy"	"C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates."	""	"TRUE"
"4903-72_1"	"SL003657"	"Calcineurin"	"Calcineurin"	"2|4"	"68178857|101023409"	"68256237|101348278"	"PPP3CA|PPP3R1"	"5530|5534"	"Q08209|P63098"	"Alzheimers Disease|Energy Metabolism|G Protein Signaling Pathways|Lymphocyte TarBase|MAPK signaling pathway|MicroRNAs in cardiomyocyte hypertrophy|Mitochondrial Gene Expression|Muscle cell TarBase|Physiological and Pathological Hypertrophy  of the Heart"	"BCR signaling pathway|C-MYB transcription factor network|Calcium signaling in the CD4+ TCR pathway|Downstream signaling in naïve CD8+ T cells|IL12 signaling mediated by STAT4|IL12-mediated signaling events|Role of Calcineurin-dependent NFAT signaling in lymphocytes"	""	"CLEC7A (Dectin-1) induces NFAT activation|Ca2+ pathway|DARPP-32 events|FCERI mediated Ca+2 mobilization"	""	"cyclosporin A"	""	"Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.|Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity."	"262"	"TRUE"
"4904-7_1"	"SL003710"	"Caspase-2"	"Caspase-2"	"7"	"143288215"	"143307696"	"CASP2"	"835"	"P42575"	"Apoptosis|Apoptosis Modulation and Signaling|Apoptosis Modulation by HSP70|MAPK signaling pathway"	"Caspase Cascade in Apoptosis|HIV-1 Nef: Negative effector of Fas and TNF-alpha|p73 transcription factor network"	""	"NADE modulates death signalling|NOD1/2 Signaling Pathway"	"Apoptosis|Cell Death Mediated by Cytotoxic Cells|Peripheral T-cell Tolerance Overview"	""	""	"Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival."	""	"TRUE"
"4905-63_1"	"SL004814"	"Coactosin-like protein"	"Coactosin-like protein"	"16"	"84565594"	"84618077"	"COTL1"	"23406"	"Q14019"	""	""	""	""	""	""	""	"Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis."	""	"TRUE"
"4906-35_1"	"SL000622"	"Coagulation Factor V"	"Coagulation Factor V"	"1"	"169514166"	"169586588"	"F5"	"2153"	"P12259"	"Blood Clotting Cascade|Complement and Coagulation Cascades"	""	""	"Common Pathway of Fibrin Clot Formation|Platelet degranulation"	"Coagulation Cascade"	"drotrecogin alfa|antithrombin alfa"	"diagnosis"	"Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin."	"165|172|413"	"TRUE"
"4907-56_1"	"SL000022"	"D-dimer"	"D-dimer"	"4"	"154562956"	"154612967"	"FGA|FGB|FGG"	"2243|2244|2266"	"P02671|P02675|P02679"	"Blood Clotting Cascade"	"Beta1 integrin cell surface interactions|Beta2 integrin cell surface interactions|Beta3 integrin cell surface interactions|Ephrin B reverse signaling|Glucocorticoid receptor regulatory network|IL6-mediated signaling events|Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling"	""	"Common Pathway of Fibrin Clot Formation|GRB2:SOS provides linkage to MAPK signaling for Integrins|Integrin alphaIIb beta3 signaling|Integrin cell surface interactions|Platelet degranulation|p130Cas linkage to MAPK signaling for integrins"	""	"F2"	""	"Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.|Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.|Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways."	""	"TRUE"
"4908-6_1"	"SL004482"	"Endoglin"	"Endoglin"	"9"	"127815012"	"127854756"	"ENG"	"2022"	"P17813"	"TGF Beta Signaling Pathway"	"ALK1 signaling events|HIF-1-alpha transcription factor network"	""	""	""	""	"disease progression|efficacy"	"Major glycoprotein of vascular endothelium. Involved in the regulation of angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGF-beta1 signaling through SMAD3."	"28|69"	"TRUE"
"4909-68_1"	"SL005167"	"Galectin-8"	"Galectin-8"	"1"	"236518000"	"236552981"	"LGALS8"	"3964"	"O00214"	""	""	""	""	""	""	""	"Lectin with a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans."	""	"TRUE"
"4910-21_1"	"SL004064"	"GIB"	"Phospholipase A2"	"12"	"120322111"	"120327789"	"PLA2G1B"	"5319"	"P04054"	"angiogenesis overview"	"Fc-epsilon receptor I signaling in mast cells"	""	"Acyl chain remodelling of PC|Acyl chain remodelling of PE|Acyl chain remodelling of PG|Acyl chain remodelling of PI|Acyl chain remodelling of PS|Synthesis of PA"	"GRM1/5 (postsynaptic) -> ion channels|GRM1/5 -> CREB signaling"	"niflumic acid"	""	"PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules."	""	"TRUE"
"4911-49_2"	"SL003643"	"Glutathione S-transferase Pi"	"Glutathione S-transferase P"	"11"	"67583595"	"67586660"	"GSTP1"	"2950"	"P09211"	"Arachidonate Epoxygenase / Epoxide Hydrolase|Diurnally regulated genes with circadian orthologs|metapathway biotransformation"	""	""	"Detoxification of Reactive Oxygen Species|Glutathione conjugation"	""	""	"diagnosis|efficacy|prognosis|safety|unspecified application"	"Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration."	""	"TRUE"
"4912-17_1"	"SL000280"	"GOT1"	"Aspartate aminotransferase, cytoplasmic"	"10"	"99396870"	"99430624"	"GOT1"	"2805"	"P17174"	"Alanine and aspartate metabolism|Glycolysis and Gluconeogenesis"	""	""	"Amino acid synthesis and interconversion (transamination)|Gluconeogenesis|Methionine salvage pathway"	""	""	""	"Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain."	"264|404"	"TRUE"
"4913-78_1"	"SL003300"	"HCC-4"	"C-C motif chemokine 16"	"17"	"35976493"	"35981528"	"CCL16"	"6360"	"O15467"	""	""	""	"Chemokine receptors bind chemokines|G alpha (i) signalling events"	"CCR1 -> STAT signaling|CCR2/5 -> STAT signaling|CCR5 -> TP53 signaling|Nociception-related CCR1 expression targets|Summarized nociception-related expression targets"	""	""	"Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES."	"30"	"TRUE"
"4914-10_1"	"SL001766"	"HCG"	"Human Chorionic Gonadotropin"	"19|6"	"49022869|87085498"	"49058860|87095406"	"CGA|CGB"	"1081|1082"	"P01215|P01233"	""	""	""	"Glycoprotein hormones"	""	""	""	"Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.|Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy."	"292"	"TRUE"
"4915-64_2"	"SL000836"	"Hemoglobin"	"Hemoglobin"	"11|16"	"5225464|172847"	"5229395|177522"	"HBA1|HBB"	"3039|3043"	"P69905|P68871"	"Folate Metabolism|Selenium Pathway|Vitamin B12 Metabolism"	""	""	"Erythrocytes take up carbon dioxide and release oxygen|Erythrocytes take up oxygen and release carbon dioxide|Factors involved in megakaryocyte development and platelet production|Scavenging of heme from plasma"	""	""	""	"Involved in oxygen transport from the lung to the various peripheral tissues.|Involved in oxygen transport from the lung to the various peripheral tissues."	"86"	"TRUE"
"4916-2_1"	"SL000460"	"IgD"	"Immunoglobulin D"	"14"	"106303099"	"106322323"	"IGHD|IGK@|IGL@"	"3495|50802|3535"	"P01880"	""	""	""	"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"	""	""	""	"IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD."	""	"TRUE"
"4917-62_1"	"SL003182"	"Integrin aVb5"	"Integrin alpha-V: beta-5 complex"	"2|3"	"186590065|124761948"	"186680901|124901418"	"ITGAV|ITGB5"	"3685|3693"	"P06756|P18084"	"Focal Adhesion|Integrin-mediated cell adhesion|Osteoblast Signaling"	"Arf6 trafficking events|Beta1 integrin cell surface interactions|Beta3 integrin cell surface interactions|Beta5 beta6 beta7 and beta8 integrin cell surface interactions|CXCR4-mediated signaling events|Integrin family cell surface interactions|Integrins in angiogenesis|Nectin adhesion pathway|Osteopontin-mediated events|PDGFR-alpha signaling pathway|PDGFR-beta signaling pathway|Plexin-D1 Signaling|S1P1 pathway|S1P3 pathway|Signaling events mediated by VEGFR1 and VEGFR2|Signaling events mediated by focal adhesion kinase|Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling"	""	"Cross-presentation of particulate exogenous antigens (phagosomes)|ECM proteoglycans|Elastic fibre formation|Integrin cell surface interactions|Laminin interactions|Molecules associated with elastic fibres|PECAM1 interactions|Signal transduction by L1|Syndecan interactions|VEGFA-VEGFR2 Pathway"	"Focal Junction Assembly"	""	""	"The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands.|Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand."	""	"TRUE"
"4919-56_2"	"SL004714"	"LIF sR"	"Leukemia inhibitory factor receptor"	"5"	"38474963"	"38608354"	"LIFR"	"3977"	"P42702"	"NA"	"NA"	"NA"	"NA"	"NA"	""	"diagnosis"	"Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells."	""	"TRUE"
"4920-10_1"	"SL000510"	"Lysozyme"	"Lysozyme C"	"12"	"69348341"	"69354234"	"LYZ"	"4069"	"P61626"	""	"C-MYB transcription factor network"	""	"Amyloids"	""	""	"unspecified application"	"Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents."	"60|133"	"TRUE"
"4922-13_1"	"SL003189"	"MIP-3b"	"C-C motif chemokine 19"	"9"	"34689567"	"34691277"	"CCL19"	"6363"	"Q99731"	""	""	""	"Chemokine receptors bind chemokines|G alpha (i) signalling events"	""	""	"disease progression|unspecified application"	"May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4."	""	"TRUE"
"4923-79_1"	"SL005201"	"MIS"	"Muellerian-inhibiting factor"	"19"	"2249309"	"2252073"	"AMH"	"268"	"P03971"	""	"ALK2 signaling events"	""	""	"ActivinR/BMPR -> SMAD1/5/9 signaling"	""	""	"This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin."	""	"TRUE"
"4924-32_1"	"SL000521"	"MMP-1"	"Interstitial collagenase"	"11"	"102789920"	"102798160"	"MMP1"	"4312"	"P03956"	"Integrated Breast Cancer Pathway|Integrated Cancer pathway|Matrix Metalloproteinases"	"AP-1 transcription factor network|Endothelins|Glucocorticoid receptor regulatory network|Syndecan-1-mediated signaling events|Validated transcriptional targets of AP1 family members Fra1 and Fra2"	""	"Activation of Matrix Metalloproteinases|Basigin interactions|Collagen degradation|Degradation of the extracellular matrix|Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"	"Nociception-related CCR1 expression targets|Summarized nociception-related expression targets"	"marimastat"	"diagnosis|efficacy|safety"	"Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity."	"129"	"TRUE"
"4925-54_2"	"SL000523"	"MMP-13"	"Collagenase 3"	"11"	"102942995"	"102955734"	"MMP13"	"4322"	"P45452"	"Endochondral Ossification|Matrix Metalloproteinases"	"Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling"	""	"Activation of Matrix Metalloproteinases|Assembly of collagen fibrils and other multimeric structures|Collagen degradation|Degradation of the extracellular matrix"	""	"marimastat"	"diagnosis"	"Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion."	""	"TRUE"
"4929-55_1"	"SL005102"	"SHBG"	"Sex hormone-binding globulin"	"17"	"7613946"	"7633383"	"SHBG"	"6462"	"P04278"	""	"Nongenotropic Androgen signaling"	""	""	""	""	"efficacy|safety"	"Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration."	""	"TRUE"
"4930-21_1"	"SL005789"	"Stanniocalcin-1"	"Stanniocalcin-1"	"8"	"23841915"	"23854807"	"STC1"	"6781"	"P52823"	""	""	""	""	""	""	"diagnosis"	"Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia."	""	"TRUE"
"4931-59_1"	"SL000024"	"TF"	"Tissue Factor"	"1"	"94529225"	"94541800"	"F3"	"2152"	"P13726"	"Complement and Coagulation Cascades"	""	""	"Extrinsic Pathway of Fibrin Clot Formation"	"Coagulation Cascade|Vitamin K metabolism"	"activated recombinant human factor VII"	"efficacy|unspecified application"	"Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade."	""	"TRUE"
"4956-2_1"	"SL000139"	"EPI"	"Epiregulin"	"4"	"74365143"	"74388751"	"EREG"	"2069"	"O14944"	"ErbB signaling pathway"	"ErbB receptor signaling network|ErbB4 signaling events"	""	"Constitutive Signaling by Aberrant PI3K in Cancer|GRB2 events in ERBB2 signaling|Nuclear signaling by ERBB4|PI3K events in ERBB2 signaling|PI3K events in ERBB4 signaling|PIP3 activates AKT signaling|SHC1 events in ERBB2 signaling|SHC1 events in ERBB4 signaling|Signaling by ERBB2|Signaling by ERBB4"	"EGFR -> AP-1/ATF2 signaling|EGFR -> AP-1/CREB/ELK-SRF/MYC signaling|EGFR -> CTNND signaling|EGFR -> NCOR2 signaling|EGFR -> SMAD1 signaling|EGFR -> ZNF259 signaling|EGFR/ERBB -> STAT signaling|EGFR/ERBB2 -> CTNNB signaling|EGFR/ERBB2 -> HIF1A signaling|EGFR/ERBB2 -> TP53 signaling|EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG signaling|ERBB2/3 -> EP300/ETS/ETV/SP1 signaling"	""	"prognosis|response to therapy"	"Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation (PubMed:9419975). Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation (PubMed:24631357)."	""	"TRUE"
"4957-1_2"	"SL004605"	"40S ribosomal protein SA"	"40S ribosomal protein SA"	"3"	"39406689"	"39412542"	"RPSA"	"3921"	"P08865"	""	""	""	""	""	""	""	"Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA."	""	"TRUE"
"4959-2_1"	"SL004925"	"AGR2"	"Anterior gradient protein 2 homolog"	"7"	"16791811"	"16833433"	"AGR2"	"10551"	"O95994"	""	""	""	""	""	""	"diagnosis"	"Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth."	""	"TRUE"
"4960-72_1"	"SL004208"	"annexin I"	"Annexin A1"	"9"	"73151757"	"73170393"	"ANXA1"	"301"	"P04083"	"Integrated Breast Cancer Pathway|Prostaglandin Synthesis and Regulation"	""	""	"Formyl peptide receptors bind formyl peptides and many other ligands|G alpha (i) signalling events|G alpha (q) signalling events|Muscle contraction"	""	"hydrocortisone|hydrocortisone/prednisone|hydrocortisone/mitoxantrone"	"diagnosis|prognosis|unspecified application"	"Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Promotes resolution of inflammation and wound healing (PubMed:25664854). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity)."	"436"	"TRUE"
"4961-17_1"	"SL004209"	"annexin II"	"Annexin A2"	"15"	"60347134"	"60402883"	"ANXA2"	"302"	"P07355"	"Epithelium TarBase|Leukocyte TarBase|Lymphocyte TarBase|Prostaglandin Synthesis and Regulation|Squamous cell  TarBase"	""	""	"Dissolution of Fibrin Clot|Muscle contraction"	"ADRA2C/ADRB2 -> synaptic endocytosis|GFs/TNF -> ion channels"	""	"diagnosis|unspecified application"	"Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:24808179, PubMed:22848640)."	"56|321"	"TRUE"
"4962-52_1"	"SL012538"	"ARMEL"	"Cerebral dopamine neurotrophic factor"	"10"	"14819250"	"14838575"	"CDNF"	"441549"	"Q49AH0"	""	""	""	""	""	""	""	"Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity)."	""	"TRUE"
"4963-19_1"	"SL011708"	"ARP19"	"cAMP-regulated phosphoprotein 19"	"15"	"52547045"	"52569883"	"ARPP19"	"10776"	"P56211"	""	""	""	"MASTL Facilitates Mitotic Progression"	""	""	""	"Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression."	""	"TRUE"
"4964-67_1"	"SL007729"	"ARTS1"	"Endoplasmic reticulum aminopeptidase 1"	"5"	"96760810"	"96808100"	"ERAP1"	"51752"	"Q9NZ08"	""	""	""	"Antigen Presentation: Folding, assembly and peptide loading of class I MHC"	""	""	""	"Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney."	"11|14|120|238|290|302"	"TRUE"
"4965-27_1"	"SL005675"	"ATP synthase beta chain"	"ATP synthase subunit beta, mitochondrial"	"12"	"56638175"	"56646068"	"ATP5B"	"506"	"P06576"	"Electron Transport Chain|Oxidative phosphorylation"	""	""	"Formation of ATP by chemiosmotic coupling|Mitochondrial protein import|Transcriptional activation of mitochondrial biogenesis"	""	""	""	"Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits."	""	"TRUE"
"4967-1_1"	"SL008177"	"C1QBP"	"Complement component 1 Q subcomponent-binding protein, mitochondrial"	"17"	"5432777"	"5448830"	"C1QBP"	"708"	"Q07021"	"Epithelium TarBase|Lymphocyte TarBase|Muscle cell TarBase"	""	""	"Intrinsic Pathway of Fibrin Clot Formation"	""	""	""	"Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular \"heads\" of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK. Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation. May function to bind initially fluid kininogen-1 to the cell membrane. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. It is postulated that the cell surface form requires docking with transmembrane proteins for downstream signaling which might be specific for a cell-type or response. By acting as C1q receptor is involved in chemotaxis of immature dendritic cells and neutrophils and is proposed to signal through CD209/DC-SIGN on immature dendritic cells, through integrin alpha-4/beta-1 during trophoblast invasion of the decidua, and through integrin beta-1 during endothelial cell adhesion and spreading. Signaling involved in inhibition of innate immune response is implicating the PI3K-AKT/PKB pathway. In mitochondrial translation may be involved in formation of functional 55S mitoribosomes; the function seems to involve its RNA-binding activity. May be involved in the nucleolar ribosome maturation process; the function may involve the exchange of FBL for RRP1 in the association with pre-ribosome particles. Involved in regulation of RNA splicing by inhibiting the RNA-binding capacity of SRSF1 and its phosphorylation. Is required for the nuclear translocation of splicing factor U2AF1L4. Involved in regulation of CDKN2A- and HRK-mediated apoptosis. Stabilizes mitochondrial CDKN2A isoform smARF. May be involved in regulation of FOXC1 transcriptional activity and NFY/CCAAT-binding factor complex-mediated transcription. In infection processes acts as an attachment site for microbial proteins, including Listeria monocytogenes internalin B and Staphylococcus aureus protein A. May play a role in antibacterial defense as it can bind to cell surface hyaluronan and inhibit Streptococcus pneumoniae hyaluronate lyase. Involved in replication of Rubella virus. May be involved in modulation of the immune response; ligation by HCV core protein is resulting in suppresion of interleukin-12 production in monocyte-derived dendritic cells. Involved in regulation of antiviral response by inhibiting DDX58- and IFIH1-mediated signaling pathways probably involving its association with MAVS after viral infection. Involved in HIV-1 replication, presumably by contributing to splicing of viral RNA."	""	"TRUE"
"4968-50_1"	"SL008099"	"CAPG"	"Macrophage-capping protein"	"2"	"85394748"	"85418432"	"CAPG"	"822"	"P40121"	"Epithelium TarBase|Leukocyte TarBase|Lymphocyte TarBase|Muscle cell TarBase"	""	""	""	""	""	""	"Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA."	""	"TRUE"
"4969-2_1"	"SL004866"	"Carbonic anhydrase I"	"Carbonic anhydrase 1"	"8"	"85327608"	"85379014"	"CA1"	"759"	"P00915"	""	"C-MYB transcription factor network"	""	"Erythrocytes take up carbon dioxide and release oxygen|Erythrocytes take up oxygen and release carbon dioxide|Reversible hydration of carbon dioxide"	""	"ethoxyzolamide|dichlorphenamide|brimonidine/brinzolamide|methazolamide|diazoxide|hydrochlorothiazide|acetazolamide|trichloromethiazide|dorzolamide|chlorothiazide|dorzolamide/timolol|brinzolamide|chlorothiazide/reserpine|quinethazone|chlorthalidone|benzthiazide|sulfacetamide|topiramate"	""	"Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea."	""	"TRUE"
"4970-55_1"	"SL000339"	"carbonic anhydrase II"	"Carbonic anhydrase 2"	"8"	"85463852"	"85481493"	"CA2"	"760"	"P00918"	""	""	""	"Erythrocytes take up carbon dioxide and release oxygen|Erythrocytes take up oxygen and release carbon dioxide|Reversible hydration of carbon dioxide"	""	"ethoxyzolamide|dichlorphenamide|phentermine/topiramate|brimonidine/brinzolamide|methazolamide|diazoxide|hydrochlorothiazide|acetazolamide|trichloromethiazide|dorzolamide|chlorothiazide|dorzolamide/timolol|brinzolamide|chlorothiazide/reserpine|quinethazone|chlorthalidone|benzthiazide|sulfacetamide|topiramate"	"diagnosis|unspecified application"	"Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6."	""	"TRUE"
"4971-1_1"	"SL008380"	"CATZ"	"Cathepsin Z"	"20"	"58995185"	"59007247"	"CTSZ"	"1522"	"Q9UBR2"	""	""	""	"Lysosome Vesicle Biogenesis|Metabolism of Angiotensinogen to Angiotensins"	""	""	""	"Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity."	"335"	"TRUE"
"4973-18_1"	"SL003728"	"cIAP-2"	"Baculoviral IAP repeat-containing protein 3"	"11"	"102317450"	"102339403"	"BIRC3"	"330"	"Q13489"	"Apoptosis|Apoptosis Modulation and Signaling|Focal Adhesion|TNF alpha Signaling Pathway"	"C-MYB transcription factor network|CD40/CD40L signaling|Caspase Cascade in Apoptosis|Ceramide signaling pathway|FAS (CD95) signaling pathway|HIV-1 Nef: Negative effector of Fas and TNF-alpha|TNF receptor signaling pathway|p75(NTR)-mediated signaling"	""	"IKK complex recruitment mediated by RIP1|NOD1/2 Signaling Pathway|RIPK1-mediated regulated necrosis|Regulation of necroptotic cell death"	"Apoptosis"	""	"diagnosis"	"Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8."	""	"TRUE"
"4976-57_1"	"SL013240"	"CRK"	"Adapter molecule crk"	"17"	"1420689"	"1463162"	"CRK"	"1398"	"P46108"	"B Cell Receptor Signaling Pathway|EGF/EGFR Signaling Pathway|ErbB signaling pathway|Focal Adhesion|Insulin Signaling|Integrin-mediated cell adhesion|Kit receptor signaling pathway|MAPK signaling pathway|Regulation of Actin Cytoskeleton|Signaling of Hepatocyte Growth Factor Receptor|TCR Signaling Pathway|angiogenesis overview"	"Alpha4 beta1 integrin signaling events|Angiopoietin receptor Tie2-mediated signaling|CXCR4-mediated signaling events|E-cadherin signaling in the nascent adherens junction|EPHA forward signaling|EPHB forward signaling|Endothelins|IGF1 pathway|Insulin Pathway|JNK signaling in the CD4+ TCR pathway|LPA receptor mediated events|Nectin adhesion pathway|Neurotrophic factor-mediated Trk receptor signaling|PDGFR-alpha signaling pathway|PDGFR-beta signaling pathway|RAC1 signaling pathway|Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)|Signaling events mediated by PTP1B|Signaling events mediated by focal adhesion kinase|Signaling events regulated by Ret tyrosine kinase|Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling|VEGFR3 signaling in lymphatic endothelium"	""	"ARMS-mediated activation|Downstream signal transduction|Regulation of actin dynamics for phagocytic cup formation|Regulation of signaling by CBL|Signal attenuation|VEGFA-VEGFR2 Pathway|p130Cas linkage to MAPK signaling for integrins"	"Adherens Junction Assembly (Nectin)|EPHB -> NMDA receptor activation|EphrinB ->  JUN signaling|FibronectinR -> AP-1/ELK-SRF/SREBF signaling|FibronectinR -> NF-kB signaling|Natural Killer Cell Inhibitory Receptor Signaling"	""	""	"The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling."	""	"TRUE"
"4978-54_2"	"SL011628"	"DBNL"	"Drebrin-like protein"	"7"	"44044640"	"44069456"	"DBNL"	"28988"	"Q9UJU6"	"TCR Signaling Pathway"	"JNK signaling in the CD4+ TCR pathway|TCR signaling in naïve CD4+ T cells"	""	"Caspase-mediated cleavage of cytoskeletal proteins"	""	""	"diagnosis"	"Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes."	""	"TRUE"
"4979-34_2"	"SL008178"	"DERM"	"Dermatopontin"	"1"	"168695459"	"168729264"	"DPT"	"1805"	"Q07507"	""	""	""	""	""	""	""	"Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity)."	"297|435"	"TRUE"
"4981-6_1"	"SL008709"	"DSC3"	"Desmocollin-3"	"18"	"30990008"	"31042815"	"DSC3"	"1825"	"Q14574"	""	""	""	""	"Desmosome Assembly"	""	""	"Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms."	""	"TRUE"
"4982-54_1"	"SL004458"	"Elafin"	"Elafin"	"20"	"45174876"	"45176544"	"PI3"	"5266"	"P19957"	""	""	""	""	""	""	""	"Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis."	"307"	"TRUE"
"4983-6_1"	"SL003522"	"ERP29"	"Endoplasmic reticulum resident protein 29"	"12"	"112013316"	"112023451"	"ERP29"	"10961"	"P30040"	""	""	""	""	""	""	""	"Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER."	""	"TRUE"
"4984-83_1"	"SL006378"	"Esterase D"	"S-formylglutathione hydrolase"	"13"	"46771256"	"46797232"	"ESD"	"2098"	"P10768"	"Phase I, non P450"	""	""	""	""	""	""	"Serine hydrolase involved in the detoxification of formaldehyde."	"73|305"	"TRUE"
"4985-11_1"	"SL005352"	"FABPE"	"Fatty acid-binding protein, epidermal"	"8"	"81280363"	"81284777"	"FABP5"	"2171"	"Q01469"	""	""	""	"Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis|Signaling by Retinoic Acid"	""	""	"disease progression"	"High specificity for fatty acids. Highest affinity for C18 chain length. Decreasing the chain length or introducing double bonds reduces the affinity. May be involved in keratinocyte differentiation."	""	"TRUE"
"4986-59_1"	"SL012248"	"FAK1"	"Focal adhesion kinase 1"	"8"	"140657900"	"141002216"	"PTK2"	"5747"	"Q05397"	"Alpha 6 Beta 4 signaling pathway|Androgen receptor signaling pathway|Angiogenesis|EGF/EGFR Signaling Pathway|ErbB signaling pathway|Focal Adhesion|Integrin-mediated cell adhesion|Prolactin Signaling Pathway|RANKL/RANK Signaling Pathway|Regulation of Actin Cytoskeleton|Signaling of Hepatocyte Growth Factor Receptor|TGF beta Signaling Pathway"	"Alpha4 beta1 integrin signaling events|Angiopoietin receptor Tie2-mediated signaling|CXCR4-mediated signaling events|Caspase Cascade in Apoptosis|EGF receptor (ErbB1) signaling pathway|EPHA2 forward signaling|EPHB forward signaling|Fc-epsilon receptor I signaling in mast cells|IGF1 pathway|Integrins in angiogenesis|Internalization of ErbB1|LPA receptor mediated events|Nectin adhesion pathway|Netrin-mediated signaling events|Nongenotropic Androgen signaling|Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)|Signaling events mediated by VEGFR1 and VEGFR2|Signaling events mediated by focal adhesion kinase|Signaling events regulated by Ret tyrosine kinase|Syndecan-4-mediated signaling events|a4b7 Integrin signaling"	""	"Apoptotic cleavage of cellular proteins|DCC mediated attractive signaling|EPHA-mediated growth cone collapse|EPHB-mediated forward signaling|GRB2:SOS provides linkage to MAPK signaling for Integrins|Integrin alphaIIb beta3 signaling|NCAM signaling for neurite out-growth|Netrin mediated repulsion signals|RHO GTPases Activate WASPs and WAVEs|Regulation of actin dynamics for phagocytic cup formation|Signal regulatory protein (SIRP) family interactions|VEGFA-VEGFR2 Pathway|p130Cas linkage to MAPK signaling for integrins"	"CHRNA7 -> NOS1 production|CholinergicRn ->  CREB signaling|EPHB -> NMDA receptor activation|EphrinB ->  JUN signaling|FibronectinR -> AP-1/ELK-SRF/SREBF signaling|FibronectinR -> CTNNB signaling|FibronectinR -> NF-kB signaling|Focal Junction Assembly|NCAM1 -> CREB/ELK-SRF/MYC signaling|VEGFR -> CTNNB signaling|VEGFR -> STAT signaling"	""	"diagnosis|disease progression|efficacy|prognosis"	"Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription."	""	"TRUE"
"4987-17_1"	"SL010373"	"FCAR"	"Immunoglobulin alpha Fc receptor"	"19"	"54545136"	"54961872"	"FCAR"	"2204"	"P24071"	""	""	""	""	""	""	""	"Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production."	""	"TRUE"
"4988-49_2"	"SL002036"	"FGFR4"	"Fibroblast growth factor receptor 4"	"5"	"177086886"	"177098144"	"FGFR4"	"2264"	"P22455"	"Regulation of Actin Cytoskeleton"	"FGF signaling pathway"	""	"Constitutive Signaling by Aberrant PI3K in Cancer|FGFR4 ligand binding and activation|FGFR4 mutant receptor activation|FRS2-mediated FGFR4 signaling|Negative regulation of FGFR4 signaling|PI-3K cascade:FGFR4|PI3K Cascade|PIP3 activates AKT signaling|Phospholipase C-mediated cascade, FGFR4|SHC-mediated cascade:FGFR4|Signaling by FGFR4 mutants|betaKlotho-mediated ligand binding"	""	""	"unspecified application"	"Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling."	""	"TRUE"
"4989-7_1"	"SL003341"	"Fibrinogen g-chain dimer"	"Fibrinogen gamma chain"	"4"	"154604134"	"154612967"	"FGG"	"2266"	"P02679"	"Blood Clotting Cascade"	"Beta1 integrin cell surface interactions|Beta2 integrin cell surface interactions|Beta3 integrin cell surface interactions|Ephrin B reverse signaling|Glucocorticoid receptor regulatory network|IL6-mediated signaling events|Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling"	""	"Common Pathway of Fibrin Clot Formation|GRB2:SOS provides linkage to MAPK signaling for Integrins|Integrin alphaIIb beta3 signaling|Integrin cell surface interactions|Platelet degranulation|p130Cas linkage to MAPK signaling for integrins"	""	"F2"	""	"Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways."	""	"TRUE"
"4990-87_1"	"SL006460"	"GP1BA"	"Platelet glycoprotein Ib alpha chain"	"17"	"4932297"	"4935030"	"GP1BA"	"2811"	"P07359"	""	"Beta2 integrin cell surface interactions"	""	"GP1b-IX-V activation signalling|Intrinsic Pathway of Fibrin Clot Formation|Platelet Adhesion to exposed collagen|Platelet Aggregation (Plug Formation)"	""	""	""	"GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium."	""	"TRUE"
"4991-12_1"	"SL012469"	"GPC5"	"Glypican-5"	"13"	"91398675"	"92873682"	"GPC5"	"2262"	"P78333"	""	""	""	"A tetrasaccharide linker sequence is required for GAG synthesis|Defective B3GAT3 causes JDSSDHD|Defective B4GALT7 causes EDS, progeroid type|Defective EXT1 causes exostoses 1, TRPS2 and CHDS|Defective EXT2 causes exostoses 2|HS-GAG biosynthesis|HS-GAG degradation|Release of Hh-Np from the secreting cell|Retinoid metabolism and transport"	""	""	""	"Cell surface proteoglycan that bears heparan sulfate."	"37|275|340"	"TRUE"
"4992-49_1"	"SL007173"	"GRN"	"Granulins"	"17"	"44345246"	"44353102"	"GRN"	"2896"	"P28799"	"Integrated Breast Cancer Pathway"	""	""	""	""	""	""	"Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling."	"71"	"TRUE"
"4993-16_1"	"SL000670"	"GSTA3"	"Glutathione S-transferase A3"	"6"	"52847910"	"52909685"	"GSTA3"	"2940"	"Q16772"	"metapathway biotransformation"	""	""	"Glutathione conjugation"	""	""	""	"Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)-pregnene-3,20-dione, precursors to testosterone and progesterone, respectively."	""	"TRUE"
"4994-178_1"	"SL002756"	"hnRNP K"	"Heterogeneous nuclear ribonucleoprotein K"	"9"	"83968083"	"83980616"	"HNRNPK"	"3190"	"P61978"	"mRNA processing"	""	""	"Processing of Capped Intron-Containing Pre-mRNA|mRNA Splicing - Major Pathway"	""	""	"prognosis"	"One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest."	""	"TRUE"
"4995-16_1"	"SL003930"	"HPG-"	"15-hydroxyprostaglandin dehydrogenase [NAD(+)]"	"4"	"174490177"	"174523154"	"HPGD"	"3248"	"P15428"	"Prostaglandin Synthesis and Regulation"	""	""	"Synthesis of Lipoxins (LX)|Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"	""	""	"prognosis"	"Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells."	""	"TRUE"
"4996-66_1"	"SL006448"	"HRG"	"Histidine-rich glycoprotein"	"3"	"186660216"	"186678240"	"HRG"	"3273"	"P04196"	""	""	""	"Dissolution of Fibrin Clot|Platelet degranulation"	""	""	""	"Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Binds heparin and heparin/glycosaminoglycans in a zinc-dependent manner. Binds heparan sulfate on the surface of liver, lung, kidney and heart endothelial cells. Binds to N-sulfated polysaccharide chains on the surface of liver endothelial cells. Inhibits rosette formation. Acts as an adapter protein and is implicated in regulating many processes such as immune complex and pathogen clearance, cell chemotaxis, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in a heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the formation of insoluble immune complexes. Tethers plasminogen to the cell surface. Binds T-cells and alters the cell morphology. Modulates angiogenesis by blocking the CD6-mediated antiangiongenic effect of thrombospondins, THBS1 and THBS2. Acts as a regulator of the vascular endothelial growth factor (VEGF) signaling pathway; inhibits endothelial cell motility by reducing VEGF-induced complex formation between PXN/paxillin and ILK/integrin-linked protein kinase and by promoting inhibition of VEGF-induced tyrosine phosphorylation of focal adhesion kinases and alpha-actinins in endothelial cells. Also plays a role in the regulation of tumor angiogenesis and tumor immune surveillance. Normalizes tumor vessels and promotes antitumor immunity by polarizing tumor-associated macrophages, leading to decreased tumor growth and metastasis."	"31|160|367|394"	"TRUE"
"4997-19_1"	"SL011616"	"IF4A3"	"Eukaryotic initiation factor 4A-III"	"17"	"80135214"	"80147183"	"EIF4A3"	"9775"	"P38919"	""	""	""	"Deadenylation of mRNA|ISG15 antiviral mechanism|Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"	""	""	""	"ATP-dependent RNA helicase. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly. Involved in craniofacial development."	""	"TRUE"
"4998-50_1"	"SL007025"	"JAK2"	"Tyrosine-protein kinase JAK2"	"9"	"4985033"	"5128183"	"JAK2"	"3717"	"O60674"	"NA"	"NA"	"NA"	"NA"	"NA"	"tofacitinib|ruxolitinib"	"efficacy|prognosis"	"Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins (PubMed:7615558). Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins (PubMed:9618263). Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation (PubMed:20098430). Plays a role in cell cycle by phosphorylating CDKN1B (PubMed:21423214). Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin (PubMed:19783980)."	""	"TRUE"
"5000-52_1"	"SL006522"	"LG3BP"	"Galectin-3-binding protein"	"17"	"78971238"	"78980109"	"LGALS3BP"	"3959"	"Q08380"	""	""	""	""	""	""	"prognosis"	"Promotes intergrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells."	""	"TRUE"
"5001-6_2"	"SL001973"	"Mammaglobin 2"	"Mammaglobin-B"	"11"	"62208668"	"62213939"	"SCGB2A1"	"4246"	"O75556"	""	""	""	""	""	""	"diagnosis"	"May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones."	""	"TRUE"
"5002-76_1"	"SL002646"	"MMP-14"	"Matrix metalloproteinase-14"	"14"	"22836557"	"22849027"	"MMP14"	"4323"	"P50281"	"Matrix Metalloproteinases|Senescence and Autophagy|angiogenesis overview"	"HIF-2-alpha transcription factor network|Signaling events mediated by focal adhesion kinase"	""	"Activation of Matrix Metalloproteinases|Collagen degradation|Degradation of the extracellular matrix"	"Extracellular Matrix Turnover"	"marimastat"	"diagnosis|prognosis|unspecified application"	"Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2."	""	"TRUE"
"5004-69_1"	"SL007453"	"MK11"	"Mitogen-activated protein kinase 11"	"22"	"50263713"	"50270767"	"MAPK11"	"5600"	"Q15759"	"IL-4 signaling pathway|Insulin Signaling|Physiological and Pathological Hypertrophy  of the Heart|Regulation of toll-like receptor signaling pathway|Toll-like receptor signaling pathway|angiogenesis overview"	"ATF-2 transcription factor network|CD40/CD40L signaling|CXCR3-mediated signaling events|FAS (CD95) signaling pathway|Glucocorticoid receptor regulatory network|IL2-mediated signaling events|IL6-mediated signaling events|Plasma membrane estrogen receptor signaling|Rapid glucocorticoid signaling|Regulation of p38-alpha and p38-beta|Regulation of retinoblastoma protein|Signaling events mediated by VEGFR1 and VEGFR2|Signaling mediated by p38-alpha and p38-beta|Thromboxane A2 receptor signaling|VEGFR3 signaling in lymphatic endothelium|p38 MAPK signaling pathway|p38 signaling mediated by MAPKAP kinases|p73 transcription factor network"	""	"Activation of PPARGC1A (PGC-1alpha) by phosphorylation|Activation of the AP-1 family of transcription factors|CDO in myogenesis|DSCAM interactions|ERK/MAPK targets|KSRP destabilizes mRNA|NOD1/2 Signaling Pathway|Oxidative Stress Induced Senescence|VEGFA-VEGFR2 Pathway|activated TAK1 mediates p38 MAPK activation|p38MAPK events"	""	"talmapimod|regorafenib"	""	"Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with those of MAPK14. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2. In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Additional examples of p38 MAPK substrates are the FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment."	""	"TRUE"
"5005-4_1"	"SL007281"	"MK12"	"Mitogen-activated protein kinase 12"	"22"	"50245450"	"50261825"	"MAPK12"	"6300"	"P53778"	"Focal Adhesion|Insulin Signaling|Integrin-mediated cell adhesion|Lymphocyte TarBase|MAPK Cascade|MAPK signaling pathway|Muscle cell TarBase|Regulation of toll-like receptor signaling pathway|Signal Transduction of S1P Receptor|Toll-like receptor signaling pathway"	"RhoA signaling pathway|Signaling mediated by p38-gamma and p38-delta"	""	"Activation of PPARGC1A (PGC-1alpha) by phosphorylation|CDO in myogenesis|DSCAM interactions|NOD1/2 Signaling Pathway|VEGFA-VEGFR2 Pathway|p38MAPK events"	"EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG signaling|IGF1R -> MEF/MYOD/MYOG signaling|NGFR -> MEF signaling|VasopressinR1 -> MEF/MYOD/NFATC/MYOG signaling|VasopressinR2 -> MEF/MYOD/NFATC/MYOG signaling"	"talmapimod"	""	"Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration."	""	"TRUE"
"5006-71_1"	"SL006993"	"MK13"	"Mitogen-activated protein kinase 13"	"6"	"36127809"	"36144524"	"MAPK13"	"5603"	"O15264"	"Insulin Signaling|MAPK signaling pathway|Regulation of toll-like receptor signaling pathway|Toll-like receptor signaling pathway"	"Signaling mediated by p38-gamma and p38-delta"	""	"DSCAM interactions|NOD1/2 Signaling Pathway|VEGFA-VEGFR2 Pathway|p38MAPK events"	""	"talmapimod"	""	"Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells."	""	"TRUE"
"5007-1_1"	"SL006920"	"MAPK14"	"Mitogen-activated protein kinase 14"	"6"	"36027677"	"36111236"	"MAPK14"	"1432"	"Q16539"	"Alpha 6 Beta 4 signaling pathway|B Cell Receptor Signaling Pathway|EGF/EGFR Signaling Pathway|Energy Metabolism|Epithelium TarBase|Estrogen signaling pathway|FSH signaling pathway|IL-1 signaling pathway|IL-4 signaling pathway|Insulin Signaling|Kit receptor signaling pathway|Leptin signaling pathway|Leukocyte TarBase|Lymphocyte TarBase|MAPK Cascade|MAPK signaling pathway|MicroRNAs in cardiomyocyte hypertrophy|Monoamine Transport|Muscle cell TarBase|Oxidative Stress|Physiological and Pathological Hypertrophy  of the Heart|Prolactin Signaling Pathway|RANKL/RANK Signaling Pathway|Regulation of toll-like receptor signaling pathway|Senescence and Autophagy|Serotonin HTR1 Group and FOS Pathway|TCR Signaling Pathway|TGF beta Signaling Pathway|TSH signaling pathway|TWEAK Signaling Pathway|Toll-like receptor signaling pathway|angiogenesis overview|p38 MAPK Signaling Pathway"	"ATF-2 transcription factor network|Angiopoietin receptor Tie2-mediated signaling|Atypical NF-kappaB pathway|BCR signaling pathway|CD40/CD40L signaling|CDC42 signaling events|CXCR3-mediated signaling events|EPO signaling pathway|Endothelins|FAS (CD95) signaling pathway|FGF signaling pathway|Glucocorticoid receptor regulatory network|IL12-mediated signaling events|IL2-mediated signaling events|IL4-mediated signaling events|IL6-mediated signaling events|RAC1 signaling pathway|Rapid glucocorticoid signaling|Regulation of Androgen receptor activity|Regulation of p38-alpha and p38-beta|Regulation of retinoblastoma protein|Retinoic acid receptors-mediated signaling|Role of Calcineurin-dependent NFAT signaling in lymphocytes|S1P2 pathway|Signaling events mediated by VEGFR1 and VEGFR2|Signaling mediated by p38-alpha and p38-beta|Thromboxane A2 receptor signaling|Trk receptor signaling mediated by the MAPK pathway|VEGFR3 signaling in lymphatic endothelium|p38 MAPK signaling pathway|p38 signaling mediated by MAPKAP kinases|p53 pathway|p73 transcription factor network"	""	"ADP signalling through P2Y purinoceptor 1|Activation of PPARGC1A (PGC-1alpha) by phosphorylation|Activation of the AP-1 family of transcription factors|CDO in myogenesis|DSCAM interactions|ERK/MAPK targets|KSRP destabilizes mRNA|NOD1/2 Signaling Pathway|Oxidative Stress Induced Senescence|Platelet sensitization by LDL|VEGFA-VEGFR2 Pathway|activated TAK1 mediates p38 MAPK activation|p38MAPK events"	"ADRA1 -> prostaglandin generation|ADRA1A -> IL6 production|AngiopoietinR -> AP-1 signaling|AngiotensinR -> CREB/ELK-SRF/TP53 signaling|BDKRB1/2 -> prostaglandin generation|CCR5 -> TP53 signaling|CHRM1 -> IL2 production|CNR1/2 -> IL1B/2/4/6/10 production|CannabinoidR -> AP-1/EGR signaling|Central T-cell Tolerance|CholinergicRm -> CREB/ELK-SRF signaling|DDR1 -> NF-kB signaling|DopamineR2 -> AP-1/CREB/ELK-SRF signaling|EDG3/5 -> AP-1/ELK-SRF signaling|EDNRA/B -> vascular motility|EGFR -> AP-1/ATF2 signaling|EGFR -> AP-1/CREB/ELK-SRF/MYC signaling|EGFR/ERBB2 -> TP53 signaling|EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG signaling|EctodysplasinR -> NF-kB signaling|EndothelinRa -> AP-1/CREB signaling|EndothelinRb -> AP-1/CREB/ELK-SRF signaling|EphrinB ->  JUN signaling|ErythropoietinR -> AP-1/CREB/MYC signaling|FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling|FibronectinR -> AP-1/ELK-SRF/SREBF signaling|FibronectinR -> NF-kB signaling|GFs/TNF -> ion channels|GRM1/5 -> CREB signaling|HGFR -> AP-1/CREB/MYC signaling|HTR1 -> IL6 production|HTR1 -> membrane transport|HTR5 -> TNF production|ICAM1 -> AP-1/CREB/ELK-SRF signaling|IGF1R -> MEF/MYOD/MYOG signaling|IL1R -> NF-kB signaling|Model of T-cell Maturation|NGFR -> AP-1/CEBPB/CREB/ELK-SRF/TP53 signaling|NGFR -> MEF signaling|NGFR -> NF-kB signaling|NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling|Nociception-related DRD2 expression targets|Nociception-related IL1B expression targets|Notch -> TCF3 signaling|PDGFR -> AP-1/MYC signaling|PTAFR -> AP-1/ATF1/CREB/ERK-SRF signaling|PTAFR -> NF-kB signaling|Regulatory T-cell Differentiation|SerotoninR1 -> FOS signaling|Summarized nociception-related expression targets|T-cell Positive Selection and Neglect-Induced Death|T-cell Receptor Signaling|T-cell receptor -> ATF/CREB signaling|T-cell-Dependent B-cell Activation|TGFBR -> AP-1 signaling|TGFBR -> ATF/GADD/MAX/TP53 signaling|TGFBR -> CREB/ELK-SRF signaling|TGFBR -> MEF/MYOD/MYOG signaling|TLR -> AP-1 signaling|TNFR -> AP-1/ATF/TP53 signaling|TNFR -> CREB/ELK-SRF signaling|TNFR -> NF-kB signaling|TNFRSF1A -> AP-1/ATF/TP53 signaling|TNFRSF1A -> CREB/ELK-SRF signaling|TNFRSF5/6 -> RB1/E2F signaling|TNFRSF6 -> DDIT3 signaling|Th1 Cell Differentiation|Th2 Cell Differentiation|ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling|ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling|VEGFR -> AP-1/CREB/MYC signaling|VEGFR -> ATF/CREB/ELK-SRF signaling|VEGFR -> NFATC signaling|VIPR -> CREB/CEBP signaling|VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling|VasopressinR1 -> MEF/MYOD/NFATC/MYOG signaling|VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling|VasopressinR2 -> MEF/MYOD/NFATC/MYOG signaling"	"talmapimod|RO-3201195"	""	"Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2. MAPK14 interacts also with casein kinase II, leading to its activation through autophosphorylation and further phosphorylation of TP53/p53. In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. In a similar way, MAPK14 phosphorylates the ubiquitin ligase SIAH2, regulating its activity towards EGLN3. MAPK14 may also inhibit the lysosomal degradation pathway of autophagy by interfering with the intracellular trafficking of the transmembrane protein ATG9. Another function of MAPK14 is to regulate the endocytosis of membrane receptors by different mechanisms that impinge on the small GTPase RAB5A. In addition, clathrin-mediated EGFR internalization induced by inflammatory cytokines and UV irradiation depends on MAPK14-mediated phosphorylation of EGFR itself as well as of RAB5A effectors. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Another p38 MAPK substrate is FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates CDC25B and CDC25C which is required for binding to 14-3-3 proteins and leads to initiation of a G2 delay after ultraviolet radiation. Phosphorylates TIAR following DNA damage, releasing TIAR from GADD45A mRNA and preventing mRNA degradation. The p38 MAPKs may also have kinase-independent roles, which are thought to be due to the binding to targets in the absence of phosphorylation. Protein O-Glc-N-acylation catalyzed by the OGT is regulated by MAPK14, and, although OGT does not seem to be phosphorylated by MAPK14, their interaction increases upon MAPK14 activation induced by glucose deprivation. This interaction may regulate OGT activity by recruiting it to specific targets such as neurofilament H, stimulating its O-Glc-N-acylation. Required in mid-fetal development for the growth of embryo-derived blood vessels in the labyrinth layer of the placenta. Also plays an essential role in developmental and stress-induced erythropoiesis, through regulation of EPO gene expression. Isoform MXI2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform EXIP may play a role in the early onset of apoptosis. Phosphorylates S100A9 at 'Thr-113'."	""	"FALSE"
"5008-51_1"	"SL001815"	"Mn SOD"	"Superoxide dismutase [Mn], mitochondrial"	"6"	"159669057"	"159762529"	"SOD2"	"6648"	"P04179"	"DNA damage response (only ATM dependent)|Folate Metabolism|Oxidative Stress|Selenium Pathway|Vitamin B12 Metabolism"	"FoxO family signaling"	""	"Detoxification of Reactive Oxygen Species"	""	""	"diagnosis|unspecified application"	"Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems."	"113"	"TRUE"
"5009-11_1"	"SL005846"	"Moesin"	"Moesin"	"X"	"65588377"	"65741931"	"MSN"	"4478"	"P26038"	"Regulation of Actin Cytoskeleton"	"Plasma membrane estrogen receptor signaling|RhoA signaling pathway"	""	"Recycling pathway of L1"	""	""	""	"Probably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit herpes simplex virus 1 infection at an early stage."	""	"TRUE"
"5011-11_1"	"SL003685"	"PBEF"	"Nicotinamide phosphoribosyltransferase"	"7"	"106248285"	"106286326"	"NAMPT"	"10135"	"P43490"	"Adipogenesis"	""	"NAD(+) biosynthesis"	"BMAL1:CLOCK,NPAS2 activates circadian gene expression|Nicotinamide salvaging"	""	""	"diagnosis|prognosis"	"Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity)."	""	"TRUE"
"5012-67_1"	"SL004296"	"Myokinase, human"	"Adenylate kinase isoenzyme 1"	"9"	"127866480"	"127877743"	"AK1"	"203"	"P00568"	""	""	""	""	""	""	"unspecified application"	"Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism."	""	"TRUE"
"5013-2_1"	"SL004915"	"NCC27"	"Chloride intracellular channel protein 1"	"6"	"31712749"	"31816046"	"CLIC1"	"1192"	"O00299"	""	""	""	""	""	""	""	"Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle."	""	"FALSE"
"5014-49_1"	"SL006091"	"NCK1"	"Cytoplasmic protein NCK1"	"3"	"136862208"	"136949823"	"NCK1"	"4690"	"P16333"	"B Cell Receptor Signaling Pathway|EGF/EGFR Signaling Pathway|ErbB signaling pathway|TCR Signaling Pathway|angiogenesis overview"	"Angiopoietin receptor Tie2-mediated signaling|Arf6 signaling events|EGF receptor (ErbB1) signaling pathway|EPHB forward signaling|Insulin Pathway|Nephrin/Neph1 signaling in the kidney podocyte|Netrin-mediated signaling events|PDGFR-beta signaling pathway|Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)|Signaling events mediated by VEGFR1 and VEGFR2|Signaling events mediated by focal adhesion kinase|Signaling events regulated by Ret tyrosine kinase|Stabilization and expansion of the E-cadherin adherens junction|TCR signaling in naïve CD4+ T cells|VEGFR1 specific signals"	""	"Activation of Rac|Antigen activates B Cell Receptor (BCR) leading to generation of second messengers|DCC mediated attractive signaling|Downstream signal transduction|Generation of second messenger molecules|Nephrin interactions|RHO GTPases Activate WASPs and WAVEs|Regulation of actin dynamics for phagocytic cup formation|VEGFA-VEGFR2 Pathway"	"EDNRA/B -> vascular motility|EndothelinRa -> AP-1/CREB signaling|T-cell Receptor Signaling"	""	""	"Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors."	""	"TRUE"
"5015-15_1"	"SL003440"	"PAFAH"	"Platelet-activating factor acetylhydrolase"	"6"	"46704201"	"46735693"	"PLA2G7"	"7941"	"Q13093"	""	"Lissencephaly gene (LIS1) in neuronal migration and development"	""	"Synthesis, secretion, and deacylation of Ghrelin"	""	"darapladib"	"diagnosis|efficacy"	"Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids."	""	"TRUE"
"5016-61_2"	"SL008933"	"PARK7"	"Protein DJ-1"	"1"	"7954291"	"7985505"	"PARK7"	"11315"	"Q99497"	""	""	""	""	""	""	"diagnosis"	"Protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteines, arginines and lysines residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) (PubMed:25416785). Plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease; functions probably related to its primary function (PubMed:17015834, PubMed:20304780, PubMed:18711745, PubMed:12796482, PubMed:19229105, PubMed:25416785). It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway (PubMed:12612053, PubMed:15502874, PubMed:14749723, PubMed:17015834, PubMed:21097510, PubMed:18711745). Its involvement in protein repair could also explain other unrelated functions. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death (PubMed:16390825). Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria (PubMed:19229105, PubMed:16632486). Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking (PubMed:18711745). Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells (PubMed:23847046). Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress (PubMed:18626009). Metal-binding protein able to bind copper as well as toxic mercury ions, enhances the cell protection mechanism against induced metal toxicity (PubMed:23792957)."	""	"TRUE"
"5017-19_1"	"SL004932"	"Peroxiredoxin-5"	"Peroxiredoxin-5, mitochondrial"	"11"	"64318088"	"64321811"	"PRDX5"	"25824"	"P30044"	"Selenium Pathway"	""	""	"Detoxification of Reactive Oxygen Species|TP53 Regulates Metabolic Genes"	""	"auranofin"	"unspecified application"	"Reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. Involved in intracellular redox signaling."	""	"TRUE"
"5018-68_1"	"SL005694"	"Peroxiredoxin-6"	"Peroxiredoxin-6"	"1"	"173477266"	"173488807"	"PRDX6"	"9588"	"P30041"	""	""	""	"Detoxification of Reactive Oxygen Species"	""	""	"unspecified application"	"Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury."	""	"TRUE"
"5019-16_2"	"SL002803"	"PGP9.5"	"Ubiquitin carboxyl-terminal hydrolase isozyme L1"	"4"	"41256413"	"41268455"	"UCHL1"	"7345"	"P09936"	"Proteasome Degradation"	"Alpha-synuclein signaling"	""	""	""	""	"diagnosis|prognosis"	"Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity."	""	"TRUE"
"5020-50_1"	"SL003653"	"phosphoglycerate kinase 1"	"Phosphoglycerate kinase 1"	"X"	"78065188"	"78129296"	"PGK1"	"5230"	"P00558"	"Glycolysis and Gluconeogenesis"	"HIF-1-alpha transcription factor network|HIF-2-alpha transcription factor network"	"glycolysis"	"Gluconeogenesis|Glycolysis"	""	""	""	"In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein)."	""	"TRUE"
"5021-13_1"	"SL004914"	"PPase"	"Inorganic pyrophosphatase"	"10"	"70202830"	"70233911"	"PPA1"	"5464"	"Q15181"	"Hypothetical Network for Drug Addiction"	""	""	"Cytosolic tRNA aminoacylation"	""	""	""	"Diphosphate + H(2)O = 2 phosphate."	"218"	"TRUE"
"5022-61_1"	"SL008176"	"PSME1"	"Proteasome activator complex subunit 1"	"14"	"24136158"	"24138967"	"PSME1"	"5720"	"Q06323"	"NA"	"NA"	"NA"	"NA"	"NA"	""	""	"Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome."	""	"TRUE"
"5023-23_1"	"SL009792"	"PUR8"	"Adenylosuccinate lyase"	"22"	"40346500"	"40369367"	"ADSL"	"158"	"P30566"	"Nucleotide Metabolism"	""	"AMP biosynthesis via de novo pathway|IMP biosynthesis via de novo pathway"	"Purine ribonucleoside monophosphate biosynthesis"	""	""	""	"Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate."	""	"TRUE"
"5024-67_1"	"SL002522"	"Rb"	"Retinoblastoma-associated protein"	"13"	"48303751"	"48481986"	"RB1"	"5925"	"P06400"	"Adipogenesis|Androgen receptor signaling pathway|Cell cycle|DNA damage response|Epithelium TarBase|FAS pathway and Stress induction of HSP regulation|G1 to S cell cycle control|ID signaling pathway|Integrated Breast Cancer Pathway|Integrated Cancer pathway|Lymphocyte TarBase|Muscle cell TarBase|Senescence and Autophagy|TSH signaling pathway|miRNA regulation of DNA Damage Response"	"ATF-2 transcription factor network|Direct p53 effectors|E2F transcription factor network|FOXM1 transcription factor network|Notch-mediated HES/HEY network|Regulation of retinoblastoma protein|p73 transcription factor network"	""	"Condensation of Prophase Chromosomes|Cyclin A:Cdk2-associated events at S phase entry|Cyclin D associated events in G1|Cyclin E associated events during G1/S transition|Formation of Senescence-Associated Heterochromatin Foci (SAHF)|Inhibition of replication initiation of damaged DNA by RB1/E2F1|Orc1 removal from chromatin|Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes"	"Cell Cycle|Cleavage of Lamina in Apoptosis|Nuclear Envelope|TNFRSF5/6 -> RB1/E2F signaling|rRNA Transcription and Processing"	""	"diagnosis|efficacy|prognosis|unspecified application"	"Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity."	""	"TRUE"
"5026-66_1"	"SL008059"	"RS3"	"40S ribosomal protein S3"	"11"	"75399486"	"75422280"	"RPS3"	"6188"	"P23396"	"Cytoplasmic Ribosomal Proteins"	""	""	"Eukaryotic Translation Termination|Formation of a pool of free 40S subunits|Formation of the ternary complex, and subsequently, the 43S complex|GTP hydrolysis and joining of the 60S ribosomal subunit|L13a-mediated translational silencing of Ceruloplasmin expression|Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)|Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)|Peptide chain elongation|Ribosomal scanning and start codon recognition|SRP-dependent cotranslational protein targeting to membrane|Translation initiation complex formation|Viral mRNA Translation"	""	""	"unspecified application"	"Involved in translation as a component of the 40S small ribosomal subunit (PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535). Represses its own translation by binding to its cognate mRNA (PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408)."	""	"TRUE"
"5028-59_1"	"SL005764"	"sCD163"	"Scavenger receptor cysteine-rich type 1 protein M130"	"12"	"7470813"	"7503893"	"CD163"	"9332"	"Q86VB7"	"TWEAK Signaling Pathway"	""	""	"Scavenging of heme from plasma"	""	""	""	"Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells."	""	"TRUE"
"5029-3_1"	"SL006528"	"SEPR"	"Seprase"	"2"	"162170684"	"162245151"	"FAP"	"2191"	"Q12884"	""	""	""	""	"Extracellular Matrix Turnover"	""	""	"Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wound healing, inflammation and tumor growth. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences, on substrate such as alpha-2-antiplasmin SERPINF2 and SPRY2 (PubMed:14751930, PubMed:16223769, PubMed:16480718, PubMed:16410248, PubMed:17381073, PubMed:18095711, PubMed:21288888, PubMed:24371721). Degrade also gelatin, heat-denatured type I collagen, but not native collagen type I and IV, vibronectin, tenascin, laminin, fibronectin, fibrin or casein (PubMed:9065413, PubMed:2172980, PubMed:7923219, PubMed:10347120, PubMed:10455171, PubMed:12376466, PubMed:16223769, PubMed:16651416, PubMed:18095711). Have also dipeptidyl peptidase activity, exhibiting the ability to hydrolyze the prolyl bond two residues from the N-terminus of synthetic dipeptide substrates provided that the penultimate residue is proline, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro (PubMed:10347120, PubMed:10593948, PubMed:16175601, PubMed:16223769, PubMed:16651416, PubMed:16410248, PubMed:17381073, PubMed:21314817, PubMed:24371721, PubMed:24717288). Natural neuropeptide hormones for dipeptidyl peptidase are the neuropeptide Y (NPY), peptide YY (PYY), substance P (TAC1) and brain natriuretic peptide 32 (NPPB) (PubMed:21314817). The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM. Plays a role in tissue remodeling during development and wound healing. Participates in the cell invasiveness towards the ECM in malignant melanoma cancers. Enhances tumor growth progression by increasing angiogenesis, collagen fiber degradation and apoptosis and by reducing antitumor response of the immune system. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner."	""	"TRUE"
"5030-52_1"	"SL006629"	"SIRT2"	"NAD-dependent protein deacetylase sirtuin-2"	"19"	"38878555"	"38899862"	"SIRT2"	"22933"	"Q8IXJ6"	""	"Signaling events mediated by HDAC Class I|Signaling events mediated by HDAC Class III"	""	""	""	""	""	"NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors. Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtubule stress agents, and hence allowing proper inheritance of chromosomes. Positively regulates the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase complex activity by deacetylating CDC20 and FZR1, then allowing progression through mitosis. Associates both with chromatin at transcriptional start sites (TSSs) and enhancers of active genes. Plays a role in cell cycle and chromatin compaction through epigenetic modulation of the regulation of histone H4 'Lys-20' methylation (H4K20me1) during early mitosis. Specifically deacetylates histone H4 at 'Lys-16' (H4K16ac) between the G2/M transition and metaphase enabling H4K20me1 deposition by SETD8 leading to ulterior levels of H4K20me2 and H4K20me3 deposition throughout cell cycle, and mitotic S-phase progression. Deacetylates SETD8 modulating SETD8 chromatin localization during the mitotic stress response. Deacetylates also histone H3 at 'Lys-57' (H3K56ac) during the mitotic G2/M transition. Upon bacterium Listeria monocytogenes infection, deacetylates 'Lys-18' of histone H3 in a receptor tyrosine kinase MET- and PI3K/Akt-dependent manner, thereby inhibiting transcriptional activity and promoting late stages of listeria infection. During oocyte meiosis progression, may deacetylate histone H4 at 'Lys-16' (H4K16ac) and alpha-tubulin, regulating spindle assembly and chromosome alignment by influencing microtubule dynamics and kinetochore function. Deacetylates alpha-tubulin at 'Lys-40' and hence controls neuronal motility, oligodendroglial cell arbor projection processes and proliferation of non-neuronal cells. Phosphorylation at Ser-368 by a G1/S-specific cyclin E-CDK2 complex inactivates SIRT2-mediated alpha-tubulin deacetylation, negatively regulating cell adhesion, cell migration and neurite outgrowth during neuronal differentiation. Deacetylates PARD3 and participates in the regulation of Schwann cell peripheral myelination formation during early postnatal development and during postinjury remyelination. Involved in several cellular metabolic pathways. Plays a role in the regulation of blood glucose homeostasis by deacetylating and stabilizing phosphoenolpyruvate carboxykinase PCK1 activity in response to low nutrient availability. Acts as a key regulator in the pentose phosphate pathway (PPP) by deacetylating and activating the glucose-6-phosphate G6PD enzyme, and therefore, stimulates the production of cytosolic NADPH to counteract oxidative damage. Maintains energy homeostasis in response to nutrient deprivation as well as energy expenditure by inhibiting adipogenesis and promoting lipolysis. Attenuates adipocyte differentiation by deacetylating and promoting FOXO1 interaction to PPARG and subsequent repression of PPARG-dependent transcriptional activity. Plays a role in the regulation of lysosome-mediated degradation of protein aggregates by autophagy in neuronal cells. Deacetylates FOXO1 in response to oxidative stress or serum deprivation, thereby negatively regulating FOXO1-mediated autophagy. Deacetylates a broad range of transcription factors and co-regulators regulating target gene expression. Deacetylates transcriptional factor FOXO3 stimulating the ubiquitin ligase SCF(SKP2)-mediated FOXO3 ubiquitination and degradation. Deacetylates HIF1A and therefore promotes HIF1A degradation and inhibition of HIF1A transcriptional activity in tumor cells in response to hypoxia. Deacetylates RELA in the cytoplasm inhibiting NF-kappaB-dependent transcription activation upon TNF-alpha stimulation. Inhibits transcriptional activation by deacetylating p53/TP53 and EP300. Deacetylates also EIF5A. Functions as a negative regulator on oxidative stress-tolerance in response to anoxia-reoxygenation conditions. Plays a role as tumor suppressor."	"208|212"	"TRUE"
"5031-10_1"	"SL008190"	"SPTA2"	"Spectrin alpha chain, non-erythrocytic 1"	"9"	"128552558"	"128633662"	"SPTAN1"	"6709"	"Q13813"	"FAS pathway and Stress induction of HSP regulation"	"Caspase Cascade in Apoptosis"	""	"Caspase-mediated cleavage of cytoskeletal proteins|Interaction between L1 and Ankyrins|NCAM signaling for neurite out-growth|Nephrin interactions"	"Apoptosis|Tight Junction Assembly (Claudins)|Tight Junction Assembly (JAMs)"	""	""	"Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane."	""	"TRUE"
"5032-64_1"	"SL009868"	"SSRP1"	"FACT complex subunit SSRP1"	"11"	"57325985"	"57335877"	"SSRP1"	"6749"	"Q08945"	""	"Validated transcriptional targets of TAp63 isoforms"	""	"Formation of HIV elongation complex in the absence of HIV Tat|Formation of HIV-1 elongation complex containing HIV-1 Tat|Formation of RNA Pol II elongation complex|HIV elongation arrest and recovery|Pausing and recovery of HIV elongation|Pausing and recovery of Tat-mediated HIV elongation|RNA Polymerase II Pre-transcription Events|RNA Polymerase II Transcription Elongation|Tat-mediated HIV elongation arrest and recovery|Tat-mediated elongation of the HIV-1 transcript"	""	""	""	"Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63."	""	"TRUE"
"5033-27_1"	"SL004737"	"Tropomyosin 1 alpha chain"	"Tropomyosin alpha-1 chain"	"15"	"63042632"	"63071915"	"TPM1"	"7168"	"P09493"	"Epithelium TarBase|Lymphocyte TarBase|Muscle cell TarBase|Squamous cell  TarBase|Striated Muscle Contraction"	""	""	"Smooth Muscle Contraction|Striated Muscle Contraction"	""	""	"diagnosis"	"Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments."	""	"TRUE"
"5034-79_1"	"SL010388"	"Trypsin 2"	"Trypsin-2"	"7"	"974021"	"977604"	"PRSS2"	"5645"	"P07478"	""	""	""	"Activation of Matrix Metalloproteinases|Alpha-defensins|Collagen degradation"	""	""	""	"In the ileum, may be involved in defensin processing, including DEFA5."	"348"	"TRUE"
"5035-7_1"	"SL000142"	"TS"	"Thymidylate synthase"	"18"	"657604"	"673578"	"TYMS"	"7298"	"P04818"	"Epithelium TarBase|Fluoropyrimidine Activity|Leukocyte TarBase|Lymphocyte TarBase|Muscle cell TarBase|One Carbon Metabolism"	"E2F transcription factor network"	"dTTP biosynthesis"	"E2F mediated regulation of DNA replication|G1/S-Specific Transcription|Pyrimidine biosynthesis"	""	"flucytosine|5-fluorouracil|trimethoprim|cyclophosphamide/epirubicin/5-fluorouracil|pralatrexate|5-fluorouracil/oxaliplatin|capecitabine/irinotecan|5-fluorouracil/irinotecan|capecitabine/docetaxel|capecitabine/lapatinib|capecitabine/ixabepilone|bevacizumab/5-fluorouracil|bevacizumab/capecitabine/oxaliplatin|cyclophosphamide/docetaxel/epirubicin/5-fluorouracil/trastuzumab|capecitabine/oxaliplatin|bevacizumab/pemetrexed|capecitabine/trastuzumab|capecitabine/gemcitabine|docetaxel/5-fluorouracil/oxaliplatin|epirubicin/5-fluorouracil/oxaliplatin|capecitabine/docetaxel/gemcitabine|capecitabine/epirubicin/oxaliplatin|capecitabine/erlotinib|capecitabine/irinotecan/oxaliplatin|bevacizumab/capecitabine/irinotecan/oxaliplatin|bevacizumab/capecitabine|capecitabine/temozolomide|5-fluorouracil/irinotecan/oxaliplatin|leucovorin/methotrexate|5-fluorouracil/gemcitabine|5-fluorouracil/imiquimod|gemcitabine/pemetrexed|raltitrexed|plevitrexed|nolatrexed|leucovorin|capecitabine|trifluridine|floxuridine|pemetrexed"	"diagnosis|disease progression|efficacy|prognosis|response to therapy"	"Contributes to the de novo mitochondrial thymidylate biosynthesis pathway."	""	"TRUE"
"5036-50_1"	"SL004782"	"TSG-6"	"Tumor necrosis factor-inducible gene 6 protein"	"2"	"151357592"	"151380048"	"TNFAIP6"	"7130"	"P98066"	""	""	""	""	""	""	"unspecified application"	"Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis."	"184|419"	"TRUE"
"5059-8_3"	"SL007464"	"AMHR2"	"Anti-Muellerian hormone type-2 receptor"	"12"	"53423855"	"53431534"	"AMHR2"	"269"	"Q16671"	"NA"	"NA"	"NA"	"NA"	"NA"	""	""	"On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone."	""	"TRUE"
"5060-62_3"	"SL004852"	"B7-H1"	"Programmed cell death 1 ligand 1"	"9"	"5450503"	"5470566"	"CD274"	"29126"	"Q9NZQ7"	""	""	""	"PD-1 signaling"	"Central T-cell Tolerance|Peripheral T-cell Tolerance Overview"	""	""	"Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production."	""	"TRUE"
"5061-27_3"	"SL004853"	"B7-H2"	"ICOS ligand"	"21|21"	"44222991|5022493"	"44240966|5040666"	"ICOSLG"	"23308"	"O75144"	""	""	""	"Costimulation by the CD28 family"	"Peripheral T-cell Tolerance Overview"	""	""	"Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity)."	""	"TRUE"
"5062-60_3"	"SL011100"	"CD226"	"CD226 antigen"	"18"	"69831158"	"69961803"	"CD226"	"10666"	"Q15762"	""	""	""	"Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"	"Leukocyte Adhesion to Endothelial Cell|Natural Killer Cell Activation through Integrins and non-ITAM-Containing Receptors"	""	""	"Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell."	""	"TRUE"
"5066-134_3"	"SL014270"	"CLM6"	"CMRF35-like molecule 6"	"17"	"74541108"	"74546143"	"CD300C"	"10871"	"Q08708"	""	""	""	""	""	""	""	"Cell membrane"	"188|304"	"TRUE"
"5068-54_3"	"SL014208"	"CRTAM"	"Cytotoxic and regulatory T-cell molecule"	"11"	"122838500"	"122872639"	"CRTAM"	"56253"	"O95727"	""	""	""	""	""	""	""	"Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo."	""	"TRUE"
"5069-9_3"	"SL004556"	"DAF"	"Complement decay-accelerating factor"	"1"	"207321508"	"207360966"	"CD55"	"1604"	"P08174"	"Complement Activation, Classical Pathway"	""	""	"Class B/2 (Secretin family receptors)|Regulation of Complement cascade"	""	""	""	"This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade."	"118"	"TRUE"
"5070-76_3"	"SL003739"	"DcR3"	"Tumor necrosis factor receptor superfamily member 6B"	"20"	"63659300"	"63698698"	"TNFRSF6B"	"8771"	"O95407"	"Apoptosis Modulation and Signaling"	""	""	""	"Apoptosis"	""	""	"Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis."	""	"TRUE"
"5071-3_3"	"SL004857"	"Desmoglein-2"	"Desmoglein-2"	"18"	"31498043"	"31549008"	"DSG2"	"1829"	"Q14126"	"Muscle cell TarBase"	""	""	"Apoptotic cleavage of cell adhesion proteins"	"Desmosome Assembly"	""	""	"Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion."	""	"TRUE"
"5073-30_2"	"SL004791"	"DR3"	"Tumor necrosis factor receptor superfamily member 25"	"1"	"6461151"	"6466195"	"TNFRSF25"	"8718"	"Q93038"	"Apoptosis|Apoptosis Modulation and Signaling|TWEAK Signaling Pathway"	""	""	""	"Apoptosis|Peripheral T-cell Tolerance Overview"	""	""	"Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis."	""	"TRUE"
"5076-53_2"	"SL014294"	"EPHAA"	"Ephrin type-A receptor 10"	"1"	"37713880"	"37765133"	"EPHA10"	"284656"	"Q5JZY3"	""	""	""	"EPH-Ephrin signaling|EPH-ephrin mediated repulsion of cells|EPHA-mediated growth cone collapse"	""	""	""	"Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5."	""	"TRUE"
"5077-28_3"	"SL007179"	"EPHB2"	"Ephrin type-B receptor 2"	"1"	"22710839"	"22921500"	"EPHB2"	"2048"	"P29323"	"Keap1-Nrf2 Pathway|NLR proteins"	"EPHB forward signaling|Ephrin B reverse signaling|EphrinB-EPHB pathway|Syndecan-2-mediated signaling events"	""	"EPH-Ephrin signaling|EPH-ephrin mediated repulsion of cells|EPHB-mediated forward signaling|Ephrin signaling|L1CAM interactions"	"EPHB -> NMDA receptor activation|EphrinB ->  JUN signaling"	""	"unspecified application"	"Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor."	"388"	"TRUE"
"5078-82_3"	"SL008414"	"EphB6"	"Ephrin type-B receptor 6"	"7"	"142855061"	"142871094"	"EPHB6"	"2051"	"O15197"	""	""	""	"EPH-Ephrin signaling|EPH-ephrin mediated repulsion of cells|EPHB-mediated forward signaling|Ephrin signaling"	""	""	""	"Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2."	""	"TRUE"
"5079-11_3"	"SL004859"	"GITR"	"Tumor necrosis factor receptor superfamily member 18"	"1"	"1203508"	"1206691"	"TNFRSF18"	"8784"	"Q9Y5U5"	"NA"	"NA"	"NA"	"NA"	"NA"	""	"diagnosis"	"Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway."	""	"TRUE"
"5080-131_3"	"SL007429"	"GPNMB"	"Transmembrane glycoprotein NMB"	"7"	"23235967"	"23275108"	"GPNMB"	"10457"	"Q14956"	""	""	""	""	""	""	"unspecified application"	"Could be a melanogenic enzyme."	"323|363"	"TRUE"
"5082-51_3"	"SL004849"	"IL-1 sR9"	"X-linked interleukin-1 receptor accessory protein-like 2"	"X"	"104566315"	"105767829"	"IL1RAPL2"	"26280"	"Q9NP60"	""	""	""	""	""	""	""	"Membrane"	""	"TRUE"
"5084-154_3"	"SL005174"	"IL-17B R"	"interleukin-17 receptor B"	"3"	"53846580"	"53865800"	"IL17RB"	"55540"	"Q9NRM6"	""	""	""	""	""	""	""	"Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells."	"445"	"TRUE"
"5085-18_3"	"SL005181"	"IL-20 Ra"	"Interleukin-20 receptor subunit alpha"	"6"	"136999971"	"137045180"	"IL20RA"	"53832"	"Q9UHF4"	""	""	""	""	""	""	""	"The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26."	""	"TRUE"
"5087-5_3"	"SL005183"	"IL-22BP"	"Interleukin-22 receptor subunit alpha-2"	"6"	"137143820"	"137173648"	"IL22RA2"	"116379"	"Q969J5"	""	""	""	""	""	""	""	"Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses."	""	"TRUE"
"5088-175_3"	"SL005185"	"IL-23 R"	"Interleukin-23 receptor"	"1"	"67166400"	"67259979"	"IL23R"	"149233"	"Q5VWK5"	""	"IL23-mediated signaling events"	""	""	"Th17 Cell Differentiation"	""	""	"Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis."	"251"	"TRUE"
"5089-11_3"	"SL005189"	"IL-7 Ra"	"Interleukin-7 receptor subunit alpha"	"5"	"35852695"	"35879603"	"IL7R"	"3575"	"P16871"	"IL-7 signaling pathway"	""	""	"Interleukin-7 signaling"	"IL7R -> FOXO/NF-kB signaling|IL7R -> STAT signaling|Model of T-cell Maturation|T-cell-Dependent B-cell Activation|V(D)J Recombination Activation"	"recombinant human interleukin-7"	""	"Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP)."	"183"	"TRUE"
"5090-49_2"	"SL005190"	"ILT-2"	"Leukocyte immunoglobulin-like receptor subfamily B member 1"	"19"	"54547681"	"54632582"	"LILRB1"	"10859"	"Q8NHL6"	""	""	""	"Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"	"Natural Killer Cell Inhibitory Receptor Signaling"	""	""	"Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions."	"41|125"	"TRUE"
"5091-28_3"	"SL005191"	"ILT-4"	"Leukocyte immunoglobulin-like receptor subfamily B member 2"	"19"	"54238904"	"54281944"	"LILRB2"	"10288"	"Q8N423"	""	""	""	"Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"	""	""	""	"Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions."	"48"	"TRUE"
"5092-51_3"	"SL007328"	"JAG1"	"Protein jagged-1"	"20"	"10637684"	"10674107"	"JAG1"	"182"	"P78504"	"Notch Signaling Pathway|Proteins and DNA Sequences in Cardicac Structures"	"Notch signaling pathway|Validated transcriptional targets of TAp63 isoforms"	""	"Activated NOTCH1 Transmits Signal to the Nucleus|Constitutive Signaling by NOTCH1 HD Domain Mutants|Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants|Constitutive Signaling by NOTCH1 PEST Domain Mutants|Constitutive Signaling by NOTCH1 t(7|NOTCH2 Activation and Transmission of Signal to the Nucleus|Signaling by NOTCH3|Signaling by NOTCH4"	"Notch -> EP300/ASCL signaling|Notch -> LEF1 signaling|Notch -> MEF/MYOD signaling|Notch -> NF-kB signaling|Notch -> RBPJ/HES/HEY signaling|Notch -> SMAD3 signaling|Notch -> TCF3 signaling"	""	"efficacy"	"Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro)."	"28"	"TRUE"
"5093-47_3"	"SL007774"	"JAG2"	"Protein jagged-2"	"14"	"105140981"	"105168824"	"JAG2"	"3714"	"Q9Y219"	"Notch Signaling Pathway"	"Notch signaling pathway|p73 transcription factor network"	""	"Activated NOTCH1 Transmits Signal to the Nucleus|Constitutive Signaling by NOTCH1 HD Domain Mutants|Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants|Constitutive Signaling by NOTCH1 PEST Domain Mutants|Constitutive Signaling by NOTCH1 t(7|NOTCH2 Activation and Transmission of Signal to the Nucleus|Signaling by NOTCH3|Signaling by NOTCH4"	"Notch -> TCF3 signaling"	""	""	"Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity)."	""	"TRUE"
"5094-62_3"	"SL009202"	"JAML1"	"Junctional adhesion molecule-like"	"11"	"118193740"	"118225094"	"AMICA1"	"120425"	"Q86YT9"	""	"Alpha4 beta1 integrin signaling events"	""	"Cell surface interactions at the vascular wall|Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"	""	""	""	"Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR."	""	"TRUE"
"5095-21_3"	"SL012698"	"KI2L4"	"Killer cell immunoglobulin-like receptor 2DL4"	"19"	"54733566"	"54844782"	"KIR2DL4"	"3805"	"Q99706"	""	""	""	"Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"	"Natural Killer Cell Activation through Integrins and non-ITAM-Containing Receptors"	""	""	"Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis."	"78|370"	"TRUE"
"5096-51_3"	"SL014269"	"KI3L2"	"Killer cell immunoglobulin-like receptor 3DL2"	"19"	"54780466"	"54897308"	"KIR3DL2"	"3812"	"P43630"	""	""	""	"Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"	"Natural Killer Cell Inhibitory Receptor Signaling"	""	"diagnosis"	"Receptor on natural killer (NK) cells for HLA-A alleles. Inhibits the activity of NK cells thus preventing cell lysis."	""	"TRUE"
"5097-14_3"	"SL014289"	"KI3S1"	"Killer cell immunoglobulin-like receptor 3DS1"	"19"	"54770963"	"54875495"	"KIR3DS1"	"3813"	"Q14943"	""	""	""	"DAP12 interactions"	"Natural Killer Cell Activation through ITAM-Containing Receptors"	""	"NA"	"Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells."	""	"TRUE"
"5098-79_3"	"SL014209"	"KLRF1"	"Killer cell lectin-like receptor subfamily F member 1"	"12"	"9827481"	"9845007"	"KLRF1"	"51348"	"Q9NZS2"	""	""	""	""	"Natural Killer Cell Activation through Integrins and non-ITAM-Containing Receptors"	""	""	"Involved in the natural killer (NK)-mediated cytolysis of PHA-induced lymphoblasts."	""	"TRUE"
"5099-14_3"	"SL005195"	"LAG-3"	"Lymphocyte activation gene 3 protein"	"12"	"6772512"	"6778455"	"LAG3"	"3902"	"P18627"	""	""	""	""	""	""	""	"Involved in lymphocyte activation. Binds to HLA class-II antigens."	""	"TRUE"
"5100-53_3"	"SL005197"	"LIMP II"	"Lysosome membrane protein 2"	"4"	"76158737"	"76213893"	"SCARB2"	"950"	"Q14108"	""	""	""	""	"Transcytosis"	""	"disease progression"	"Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting."	""	"TRUE"
"5102-55_3"	"SL005200"	"MICB"	"MHC class I polypeptide-related sequence B"	"6"	"31485545"	"31587478"	"MICB"	"4277"	"Q29980"	""	""	""	""	"Natural Killer Cell Activation|Natural Killer Cell Activation through C-type Lectin-like Receptors"	""	"safety"	"Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis."	"105|146|180|198|199|206|253|260|277|295|330"	"TRUE"
"5103-30_3"	"SL014288"	"MO2R1"	"Cell surface glycoprotein CD200 receptor 1"	"3"	"112921209"	"112975122"	"CD200R1"	"131450"	"Q8TD46"	""	""	""	"Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"	""	""	""	"Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200."	""	"TRUE"
"5104-57_3"	"SL005207"	"NKp46"	"Natural cytotoxicity triggering receptor 1"	"19"	"54576966"	"54946235"	"NCR1"	"9437"	"O76036"	""	""	""	""	"Natural Killer Cell Activation through ITAM-Containing Receptors"	""	""	"Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis."	""	"TRUE"
"5105-2_3"	"SL005208"	"Nogo Receptor"	"Reticulon-4 receptor"	"22"	"20241415"	"20283246"	"RTN4R"	"65078"	"Q9BZR6"	""	"p75(NTR)-mediated signaling"	""	"Axonal growth inhibition (RHOA activation)"	""	""	""	"Receptor for RTN4, OMG and MAG. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. Mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development."	""	"TRUE"
"5106-52_3"	"SL007356"	"NOTC2"	"Neurogenic locus notch homolog protein 2"	"1"	"119911553"	"120069626"	"NOTCH2"	"4853"	"Q04721"	"Epithelium TarBase|Lymphocyte TarBase|Muscle cell TarBase|Neural Crest Differentiation|Notch Signaling Pathway"	"Notch signaling pathway"	""	"NOTCH2 Activation and Transmission of Signal to the Nucleus|NOTCH2 intracellular domain regulates transcription|Notch-HLH transcription pathway|Pre-NOTCH Processing in Golgi|Pre-NOTCH Processing in the Endoplasmic Reticulum|Pre-NOTCH Transcription and Translation"	"Notch -> TCF3 signaling"	""	"unspecified application"	"Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Positively regulates self-renewal of liver cancer cells (PubMed:25985737)."	""	"TRUE"
"5107-7_2"	"SL005703"	"Notch 1"	"Neurogenic locus notch homolog protein 1"	"9"	"136494444"	"136545862"	"NOTCH1"	"4851"	"P46531"	"Epithelium TarBase|Heart Development|Lymphocyte TarBase|Muscle cell TarBase|Neural Crest Differentiation|Notch Signaling Pathway|Proteins and DNA Sequences in Cardicac Structures"	"Notch signaling pathway|Notch-mediated HES/HEY network|Presenilin action in Notch and Wnt signaling|Validated transcriptional targets of deltaNp63 isoforms"	""	"Activated NOTCH1 Transmits Signal to the Nucleus|Constitutive Signaling by NOTCH1 HD Domain Mutants|Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants|Constitutive Signaling by NOTCH1 PEST Domain Mutants|Constitutive Signaling by NOTCH1 t(7|Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling|NOTCH1 Intracellular Domain Regulates Transcription|Notch-HLH transcription pathway|Pre-NOTCH Processing in Golgi|Pre-NOTCH Processing in the Endoplasmic Reticulum|Pre-NOTCH Transcription and Translation|Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells"	"Adherens Junction Assembly (Cadherins)|EphrinR -> STAT signaling|Model of T-cell Maturation|Notch -> EP300/ASCL signaling|Notch -> LEF1 signaling|Notch -> MEF/MYOD signaling|Notch -> NF-kB signaling|Notch -> SMAD3 signaling|Notch -> TCF3 signaling|Transcriptional Activation of Immunoglobulin Genes"	""	"diagnosis|efficacy"	"Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO)."	"69"	"TRUE"
"5108-72_3"	"SL005209"	"Notch-3"	"Neurogenic locus notch homolog protein 3"	"19"	"15159038"	"15200981"	"NOTCH3"	"4854"	"Q9UM47"	"Neural Crest Differentiation|Notch Signaling Pathway"	"Notch signaling pathway"	""	"Notch-HLH transcription pathway|Pre-NOTCH Processing in Golgi|Pre-NOTCH Processing in the Endoplasmic Reticulum|Pre-NOTCH Transcription and Translation|Signaling by NOTCH3"	""	""	"unspecified application"	"Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity)."	""	"TRUE"
"5109-24_3"	"SL005210"	"Nr-CAM"	"Neuronal cell adhesion molecule"	"7"	"108147623"	"108456717"	"NRCAM"	"4897"	"Q92823"	""	""	""	"Interaction between L1 and Ankyrins|Neurofascin interactions|NrCAM interactions"	""	""	""	"Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier."	""	"TRUE"
"5110-84_3"	"SL009054"	"NRX1B"	"Neurexin-1-beta"	"2"	"49918505"	"51032561"	"NRXN1"	"9378"	"P58400"	""	""	""	""	""	""	""	"Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity)."	""	"TRUE"
"5111-15_3"	"SL008728"	"NRX3B"	"Neurexin-3-beta"	"14"	"78242391"	"79868290"	"NRXN3"	"9369"	"Q9HDB5"	""	""	""	""	""	""	""	"Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May play a role in angiogenesis (By similarity)."	""	"TRUE"
"5112-73_3"	"SL014268"	"OX2G"	"OX-2 membrane glycoprotein"	"3"	"112332347"	"112362812"	"CD200"	"4345"	"P41217"	""	""	""	"Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"	""	""	""	"Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues."	"28"	"TRUE"
"5114-65_3"	"SL005212"	"Prolactin Receptor"	"Prolactin receptor"	"5"	"35048756"	"35230589"	"PRLR"	"5618"	"P16471"	"Adipogenesis|Ovarian Infertility Genes|Prolactin Signaling Pathway"	"ErbB4 signaling events|Signaling events mediated by PTP1B"	""	"Growth hormone receptor signaling|Prolactin receptor signaling"	"ProlactinR -> STAT signaling"	"fluoxymesterone"	""	"This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling."	""	"TRUE"
"5115-31_3"	"SL005213"	"RELT"	"Tumor necrosis factor receptor superfamily member 19L"	"11"	"73376264"	"73397474"	"RELT"	"84957"	"Q969Z4"	""	""	""	""	""	""	""	"Mediates activation of NF-kappa-B. May play a role in T-cell activation."	"258"	"TRUE"
"5116-62_2"	"SL007680"	"ROBO2"	"Roundabout homolog 2"	"3"	"75906695"	"77649964"	"ROBO2"	"6092"	"Q9HCK4"	""	""	""	"Regulation of Commissural axon pathfinding by Slit and Robo"	""	""	""	"Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development."	""	"TRUE"
"5117-14_3"	"SL014148"	"ROBO3"	"Roundabout homolog 3"	"11"	"124865386"	"124881470"	"ROBO3"	"64221"	"Q96MS0"	""	""	""	"Regulation of Commissural axon pathfinding by Slit and Robo"	""	""	""	"Thought to be involved during neural development in axonal navigation at the ventral midline of the neural tube. In spinal chord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1 (By similarity). Required for hindbrain axon midline crossing."	""	"TRUE"
"5118-74_2"	"SL008309"	"RTN4"	"Reticulon-4"	"2"	"54972187"	"55112621"	"RTN4"	"57142"	"Q9NQC3"	"Epithelium TarBase|Leukocyte TarBase|Lymphocyte TarBase|Muscle cell TarBase|Squamous cell  TarBase"	"p75(NTR)-mediated signaling"	""	"Axonal growth inhibition (RHOA activation)"	""	""	"diagnosis"	"Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing."	""	"TRUE"
"5122-92_2"	"SL005214"	"Semaphorin-6A"	"Semaphorin-6A"	"5"	"116443616"	"116574934"	"SEMA6A"	"57556"	"Q9H2E6"	""	""	""	"Other semaphorin interactions"	""	""	""	"Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation (By similarity)."	""	"TRUE"
"5124-69_3"	"SL005169"	"sICAM-5"	"Intercellular adhesion molecule 5"	"19"	"10289981"	"10296778"	"ICAM5"	"7087"	"Q9UMF0"	""	""	""	""	""	""	""	"ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2)."	"1|351"	"TRUE"
"5125-6_3"	"SL014292"	"SIG14"	"Sialic acid-binding Ig-like lectin 14"	"19"	"51642553"	"51646801"	"SIGLEC14"	"100049587"	"Q08ET2"	""	""	""	"DAP12 interactions"	""	""	"NA"	"Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors."	"39|219|381"	"TRUE"
"5128-53_3"	"SL014228"	"SLAF6"	"SLAM family member 6"	"1"	"160485030"	"160523262"	"SLAMF6"	"114836"	"Q96DU3"	""	""	""	""	"Natural Killer Cell Activation through ITSM-Containing Receptors"	""	""	"Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors (PubMed:11489943, PubMed:16920955). Positive signaling in NK cells implicates phosphorylation of VAV1. NK cell activation seems to depend on SH2D1B and not on SH2D1A (PubMed:16920955). In conjunction with SLAMF1 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage (By similarity). Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727, PubMed:16920955). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). In conjunction with SLAMF1 and CD84/SLAMF5 may be a negative regulator of the humoral immune response. In the absence of SH2D1A/SAP can transmit negative signals to CD4(+) T-cells and NKT cells. Negatively regulates germinal center formation by inhibiting T-cell:B-cell adhesion; the function probably implicates increased association with PTPN6/SHP-1 via ITSMs in absence of SH2D1A/SAP. However, reported to be involved in maintaining B-cell tolerance in germinal centers and in preventing autoimmunity (By similarity)."	""	"TRUE"
"5129-12_3"	"SL005221"	"SREC-I"	"Scavenger receptor class F member 1"	"17"	"1633858"	"1645789"	"SCARF1"	"8578"	"Q14162"	""	""	""	"Scavenging by Class F Receptors"	""	""	""	"Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity)."	"128"	"TRUE"
"5130-67_3"	"SL005222"	"SREC-II"	"Scavenger receptor class F member 2"	"22"	"20424585"	"20437859"	"SCARF2"	"91179"	"Q96GP6"	""	""	""	""	""	""	""	"Probable adhesion protein, which mediates homophilic and heterophilic interactions. In contrast to SCARF1, it poorly mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL) (By similarity)."	""	"TRUE"
"5131-15_3"	"SL004863"	"TAJ"	"Tumor necrosis factor receptor superfamily member 19"	"13"	"23570370"	"23676104"	"TNFRSF19"	"55504"	"Q9NS68"	""	""	""	""	""	""	""	"Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death."	""	"TRUE"
"5132-71_3"	"SL005223"	"TCCR"	"Interleukin-27 receptor subunit alpha"	"19"	"14031748"	"14053216"	"IL27RA"	"9466"	"Q6UWB1"	""	"IL27-mediated signaling events"	""	""	"Th1 Cell Differentiation"	""	""	"Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms."	"69"	"TRUE"
"5133-17_3"	"SL002078"	"TGF-b R II"	"TGF-beta receptor type-2"	"3"	"30606502"	"30694142"	"TGFBR2"	"7048"	"P37173"	"Adipocyte TarBase|Epithelium TarBase|Integrated Breast Cancer Pathway|Lymphocyte TarBase|MAPK signaling pathway|Muscle cell TarBase|Squamous cell  TarBase|TGF Beta Signaling Pathway|TGF beta Signaling Pathway"	"ALK1 signaling events|Beta3 integrin cell surface interactions|Glypican 1 network|Integrins in angiogenesis|TGF-beta receptor signaling"	""	"Downregulation of TGF-beta receptor signaling|SMAD2/3 MH2 Domain Mutants in Cancer|SMAD2/3 Phosphorylation Motif Mutants in Cancer|TGF-beta receptor signaling activates SMADs|TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)|TGFBR1 KD Mutants in Cancer|TGFBR1 LBD Mutants in Cancer|TGFBR2 Kinase Domain Mutants in Cancer|TGFBR2 MSI Frameshift Mutants in Cancer"	"Activation of Immunoglobulin Class-Switch Recombination|Cell Cycle|Regulatory T-cell Differentiation|TGFBR -> AP-1 signaling|TGFBR -> ATF/GADD/MAX/TP53 signaling|TGFBR -> CREB/ELK-SRF signaling|TGFBR -> MEF/MYOD/MYOG signaling|TGFBR -> SMAD1/5/9 signaling|TGFBR/BMPR -> SMAD2/3 signaling"	""	""	"Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways."	""	"TRUE"
"5134-52_2"	"SL007547"	"TIMD3"	"Hepatitis A virus cellular receptor 2"	"5"	"157085832"	"157142869"	"HAVCR2"	"84868"	"Q8TDQ0"	""	""	""	"Interleukin-2 signaling"	""	""	"unspecified application"	"Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand (PubMed:24825777). Regulates macrophage activation (PubMed:11823861). Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance (PubMed:14556005). In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion. The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits, and/or LGALS9-dependent recruitment of PTPRC to the immunological synapse (PubMed:24337741, PubMed:26492563). In contrast, shown to activate TCR-induced signaling in T cells probably implicating ZAP70, LCP2, LCK and FYN (By similarity). Expressed on Treg cells can inhibit Th17 cell responses (PubMed:24838857). Receptor for LGALS9 (PubMed:16286920, PubMed:24337741). Binding to LGALS9 is believed to result in suppression of T cell responses; the resulting apoptosis of antigen-specific cells may implicate HAVCR2 phosphorylation and disruption of its association with BAG6. Binding to LGALS9 is proposed to be involved in innate immune response to intracellular pathogens. Expressed on Th1 cells interacts with LGALS9 expressed on Mycobacterium tuberculosis-infected macrophages to stimulate antibactericidal activity including IL-1 beta secretion and to restrict intracellular bacterial growth (By similarity). However, the function as receptor for LGALS9 has been challenged (PubMed:23555261). Also reported to enhance CD8+ T cell responses to an acute infection such as by Listeria monocytogenes (By similarity). Receptor for phosphatidylserine (PtSer); PtSer-binding is calcium-dependent. May recognize PtSer on apoptotic cells leading to their phagocytosis. Mediates the engulfment of apoptotic cells by dendritic cells. Expressed on T cells, promotes conjugation but not engulfment of apoptotic cells. Expressed on dendritic cells (DCs) positively regulates innate immune response and in synergy with Toll-like receptors promotes secretion of TNF-alpha. In tumor-imfiltrating DCs suppresses nucleic acid-mediated innate immune repsonse by interaction with HMGB1 and interfering with nucleic acid-sensing and trafficking of nucleid acids to endosomes (By similarity). Expressed on natural killer (NK) cells acts as a coreceptor to enhance IFN-gamma production in response to LGALS9 (PubMed:22323453). In contrast, shown to suppress NK cell-mediated cytotoxicity (PubMed:22383801). Negatively regulates NK cell function in LPS-induced endotoxic shock (By similarity)."	"101"	"TRUE"
"5138-50_3"	"SL004366"	"TWEAKR"	"Tumor necrosis factor receptor superfamily member 12A"	"16"	"3018445"	"3022383"	"TNFRSF12A"	"51330"	"Q9NP84"	"TWEAK Signaling Pathway"	""	""	""	""	""	""	"Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins."	""	"TRUE"
"5139-32_3"	"SL005230"	"UNC5H3"	"Netrin receptor UNC5C"	"4"	"95162504"	"95549206"	"UNC5C"	"8633"	"O95185"	""	"Netrin-mediated signaling events"	""	"Netrin mediated repulsion signals"	""	""	""	"Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand."	""	"TRUE"
"5140-56_3"	"SL005231"	"UNC5H4"	"Netrin receptor UNC5D"	"8"	"35235457"	"35796550"	"UNC5D"	"137970"	"Q6UXZ4"	""	""	""	"Netrin mediated repulsion signals"	""	""	""	"Receptor for the netrin NTN4 that promotes neuronal cell survival (By similarity). Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). May play a role in apoptosis in response to DNA damage (PubMed:24691657). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:24519068). Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (By similarity)."	""	"TRUE"
"5178-5_3"	"SL011406"	"PDE7A"	"High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A"	"8"	"65717510"	"65842322"	"PDE7A"	"5150"	"Q13946"	"G Protein Signaling Pathways"	""	"3',5'-cyclic AMP degradation"	"G alpha (s) signalling events"	""	"dyphylline|nitroglycerin|aminophylline|anagrelide|milrinone|dipyridamole|ketotifen|tolbutamide|theophylline|pentoxifylline"	""	"Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction."	""	"TRUE"
"5183-53_3"	"SL016548"	"AMPK a1b1g1"	"AMP Kinase (alpha1beta1gamma1)"	"12|12|5"	"119667753|49002274|40759379"	"119681630|49019197|40798374"	"PRKAA1|PRKAB1|PRKAG1"	"5562|5564|5571"	"Q13131|Q9Y478|P54619"	"AMPK signaling|Energy Metabolism|TOR signaling"	"Direct p53 effectors|LKB1 signaling events|Signaling events mediated by VEGFR1 and VEGFR2"	""	"Activation of PPARGC1A (PGC-1alpha) by phosphorylation|Regulation of AMPK activity via LKB1|Regulation of Rheb GTPase activity by AMPK|TP53 Regulates Metabolic Genes|Translocation of GLUT4 to the plasma membrane"	""	""	""	"Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2. In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1. AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it. May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it. Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo. Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1.|Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).|AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive."	""	"TRUE"
"5193-51_3"	"SL002542"	"K-ras"	"GTPase KRas"	"12"	"25204789"	"25250936"	"KRAS"	"3845"	"P01116"	"EGF/EGFR Signaling Pathway|Epithelium TarBase|ErbB signaling pathway|G Protein Signaling Pathways|IL-5 signaling pathway|Integrated Breast Cancer Pathway|Lymphocyte TarBase|MAPK Cascade|MAPK signaling pathway|Muscle cell TarBase|Regulation of Actin Cytoskeleton|angiogenesis overview"	"C-MYB transcription factor network|CXCR3-mediated signaling events|Class I PI3K signaling events|Downstream signaling in naïve CD8+ T cells|EGF receptor (ErbB1) signaling pathway|EPHB forward signaling|ErbB1 downstream signaling|ErbB2/ErbB3 signaling events|GMCSF-mediated signaling events|IL2-mediated signaling events|Internalization of ErbB1|Neurotrophic factor-mediated Trk receptor signaling|PDGFR-beta signaling pathway|Plasma membrane estrogen receptor signaling|Ras signaling in the CD4+ TCR pathway|Regulation of Ras family activation|SHP2 signaling|TCR signaling in naïve CD4+ T cells|TCR signaling in naïve CD8+ T cells|Trk receptor signaling mediated by PI3K and PLC-gamma|Trk receptor signaling mediated by the MAPK pathway|mTOR signaling pathway"	""	"Activation of RAS in B cells|CD209 (DC-SIGN) signaling|Constitutive Signaling by EGFRvIII|Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants|DAP12 signaling|Downstream signal transduction|EGFR Transactivation by Gastrin|FCERI mediated MAPK activation|FRS-mediated FGFR1 signaling|FRS-mediated FGFR2 signaling|FRS-mediated FGFR3 signaling|FRS2-mediated FGFR4 signaling|GRB2 events in EGFR signaling|GRB2 events in ERBB2 signaling|MEK activation|NCAM signaling for neurite out-growth|RAF activation|RAF phosphorylates MEK|SHC-mediated cascade:FGFR1|SHC-mediated cascade:FGFR2|SHC-mediated cascade:FGFR3|SHC-mediated cascade:FGFR4|SHC-mediated signalling|SHC1 events in EGFR signaling|SHC1 events in ERBB2 signaling|SHC1 events in ERBB4 signaling|SOS-mediated signalling|Signaling by FGFR1 mutants|Signaling by FGFR2 mutants|Signaling by FGFR3 mutants|Signaling by FGFR4 mutants|Signaling by SCF-KIT|Signalling to RAS|Tie2 Signaling|VEGFR2 mediated cell proliferation|p38MAPK events"	"AGER ->  CREB/SP1 signaling|AGER ->  NF-kB signaling|CHRNA7 -> NOS1 production|CholinergicRn ->  CREB signaling"	""	"diagnosis|efficacy|prognosis|response to therapy|unspecified application"	"Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation (PubMed:23698361, PubMed:22711838)."	""	"TRUE"
"5196-7_3"	"SL006476"	"NMT1"	"Glycylpeptide N-tetradecanoyltransferase 1"	"17"	"45051610"	"45109016"	"NMT1"	"4836"	"P30419"	""	""	""	"Activation, myristolyation of BID and translocation to mitochondria|Inactivation, recovery and regulation of the phototransduction cascade|Late Phase of HIV Life Cycle"	""	""	""	"Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins."	""	"TRUE"
"5201-50_4"	"SL016554"	"PDE9A"	"High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A"	"21"	"42653636"	"42775509"	"PDE9A"	"5152"	"O76083"	""	""	""	""	""	""	""	"Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP (PubMed:9624146, PubMed:18757755, PubMed:21483814). Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart (PubMed:25799991). Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory (By similarity)."	""	"TRUE"
"5202-4_3"	"SL007373"	"PPID"	"Peptidyl-prolyl cis-trans isomerase D"	"4"	"158709134"	"158723396"	"PPID"	"5481"	"Q08752"	""	"C-MYB transcription factor network"	""	""	""	""	""	"PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines. May be involved in hepatitis C virus (HCV) replication and release."	"156"	"TRUE"
"5204-13_3"	"SL005308"	"PSME3"	"Proteasome activator complex subunit 3"	"17"	"42824385"	"42843758"	"PSME3"	"10197"	"P61289"	"Proteasome Degradation"	""	""	"APC/C:Cdc20 mediated degradation of Securin|APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1|AUF1 (hnRNP D0) destabilizes mRNA|Activation of NF-kappaB in B cells|Antigen processing: Ubiquitination & Proteasome degradation|Asymmetric localization of PCP proteins|Autodegradation of Cdh1 by Cdh1:APC/C|Autodegradation of the E3 ubiquitin ligase COP1|CDK-mediated phosphorylation and removal of Cdc6|CDT1 association with the CDC6:ORC:origin complex|CLEC7A (Dectin-1) signaling|Cdc20:Phospho-APC/C mediated degradation of Cyclin A|Cross-presentation of soluble exogenous antigens (endosomes)|Dectin-1 mediated noncanonical NF-kB signaling|Degradation of GLI1 by the proteasome|Degradation of GLI2 by the proteasome|Degradation of beta-catenin by the destruction complex|ER-Phagosome pathway|GLI3 is processed to GLI3R by the proteasome|Hedgehog 'on' state|Hedgehog ligand biogenesis|Hh mutants that don't undergo autocatalytic processing are degraded by ERAD|Orc1 removal from chromatin|Regulation of activated PAK-2p34 by proteasome mediated degradation|Regulation of ornithine decarboxylase (ODC)|SCF(Skp2)-mediated degradation of p27/p21|SCF-beta-TrCP mediated degradation of Emi1|Separation of Sister Chromatids|Ubiquitin Mediated Degradation of Phosphorylated Cdc25A|Ubiquitin-dependent degradation of Cyclin D1|Vif-mediated degradation of APOBEC3G|Vpu mediated degradation of CD4|degradation of AXIN|degradation of DVL"	""	""	""	"Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978)."	""	"TRUE"
"5223-59_3"	"SL015728"	"GCKR"	"Glucokinase regulatory protein"	"2"	"27496842"	"27523684"	"GCKR"	"2646"	"Q14397"	""	""	""	"Regulation of Glucokinase by Glucokinase Regulatory Protein"	""	""	""	"Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity."	""	"TRUE"
"5225-50_3"	"SL016550"	"CK2-A1:B"	"Casein kinase II 2-alpha:2-beta heterotetramer"	"20|6"	"473591|31647414"	"543821|31749825"	"CSNK2A1|CSNK2B"	"1457|1460"	"P68400|P67870"	""	"ALK1 signaling events|Atypical NF-kappaB pathway|DNA-PK pathway in nonhomologous end joining|E-cadherin signaling in the nascent adherens junction|Signaling mediated by p38-alpha and p38-beta"	""	"Condensation of Prometaphase Chromosomes|Signal transduction by L1|WNT mediated activation of DVL"	""	""	""	"Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation. Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:19188443, PubMed:20625391, PubMed:22406621). Phosphorylates CCAR2 at 'Thr-454' in gastric carcinoma tissue (PubMed:24962073).|Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit."	""	"TRUE"
"5226-36_3"	"SL016551"	"CK2-A2:B"	"Casein kinase II 2-alpha':2-beta heterotetramer"	"16|6"	"58157907|31647414"	"58197920|31749825"	"CSNK2A2|CSNK2B"	"1459|1460"	"P19784|P67870"	""	"ALK1 signaling events|Atypical NF-kappaB pathway|DNA-PK pathway in nonhomologous end joining|E-cadherin signaling in the nascent adherens junction|Signaling mediated by p38-alpha and p38-beta"	""	"Condensation of Prometaphase Chromosomes|Signal transduction by L1|WNT mediated activation of DVL"	""	""	""	"Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV.|Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit."	""	"TRUE"
"5227-60_3"	"SL006921"	"PDK1"	"[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial"	"2"	"172555373"	"172608669"	"PDK1"	"5163"	"Q15118"	"DNA damage response (only ATM dependent)|EPO Receptor Signaling|ErbB signaling pathway|TCA Cycle|TGF beta Signaling Pathway"	""	""	"Regulation of pyruvate dehydrogenase (PDH) complex|Signaling by Retinoic Acid"	""	"dichloroacetic acid"	""	"Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress."	"140"	"TRUE"
"5228-25_2"	"SL006189"	"KIF23"	"Kinesin-like protein KIF23"	"15"	"69414246"	"69448427"	"KIF23"	"9493"	"Q02241"	""	"Aurora B signaling"	""	"Kinesins|MHC class II antigen presentation|Mitotic Telophase/Cytokinesis"	""	""	""	"Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro."	""	"TRUE"
"5229-90_3"	"SL014735"	"IMDH1"	"Inosine-5'-monophosphate dehydrogenase 1"	"7"	"128392277"	"128410252"	"IMPDH1"	"3614"	"P20839"	""	""	""	""	""	"thioguanine|VX-944|pegintron/ribavirin|PEG-interferon alfa-2a/ribavirin|nitazoxanide/peginterferon alfa-2a/ribavirin|interferon alfa-2b/ribavirin|mycophenolate mofetil|mycophenolic acid|ribavirin"	""	"Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors."	"108|353"	"TRUE"
"5230-99_3"	"SL016557"	"HMGR"	"3-hydroxy-3-methylglutaryl-coenzyme A reductase"	"5"	"75336329"	"75362104"	"HMGCR"	"3156"	"P04035"	"AMPK signaling|Cholesterol Biosynthesis|Integrated Breast Cancer Pathway|SREBF and miR33 in cholesterol and lipid homeostasis|Statin Pathway"	""	"(R)-mevalonate biosynthesis"	"Activation of gene expression by SREBF (SREBP)|Cholesterol biosynthesis|PPARA activates gene expression"	""	"aspirin/pravastatin|ezetimibe/fluvastatin|atorvastatin/niacin|atorvastatin/ezetimibe|ezetimibe/rosuvastatin|simvastatin/sitagliptin|choline fenofibrate/simvastatin|fenofibrate/simvastatin|pitavastatin|lovastatin/niacin|ezetimibe/simvastatin|amlodipine/atorvastatin|fluvastatin|cerivastatin|atorvastatin|pravastatin|simvastatin|lovastatin|mevastatin|rosuvastatin"	"efficacy"	"Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins."	""	"TRUE"
"5231-79_3"	"SL012707"	"PCSK9"	"Proprotein convertase subtilisin/kexin type 9"	"1"	"55039548"	"55064852"	"PCSK9"	"255738"	"Q8NBP7"	""	""	""	""	""	""	"unspecified application"	"Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments (PubMed:18039658). Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation (PubMed:18799458, PubMed:17461796, PubMed:18197702, PubMed:22074827). Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway (PubMed:18660751). Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways."	""	"TRUE"
"5236-2_3"	"SL007145"	"NR1D1"	"Nuclear receptor subfamily 1 group D member 1"	"17"	"40092787"	"40100725"	"NR1D1"	"9572"	"P20393"	""	"Circadian rhythm pathway"	""	"BMAL1:CLOCK,NPAS2 activates circadian gene expression|Circadian Clock|NR1D1 (REV-ERBA) represses gene expression|Nuclear Receptor transcription pathway|PPARA activates gene expression|RORA activates gene expression|Transcriptional activation of mitochondrial biogenesis"	"Circadian Clock"	""	""	"Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARTNL/BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nucleotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and regulates the levels of its ligand heme by repressing the expression of PPARGC1A, a potent inducer of heme synthesis. Regulates lipid metabolism by repressing the expression of APOC3 and by influencing the activity of sterol response element binding proteins (SREBPs); represses INSIG2 which interferes with the proteolytic activation of SREBPs which in turn govern the rhythmic expression of enzymes with key functions in sterol and fatty acid synthesis. Regulates gluconeogenesis via repression of G6PC and PEPCK and adipocyte differentiation via repression of PPARG. Regulates glucagon release in pancreatic alpha-cells via the AMPK-NAMPT-SIRT1 pathway and the proliferation, glucose-induced insulin secretion and expression of key lipogenic genes in pancreatic-beta cells. Positively regulates bile acid synthesis by increasing hepatic expression of CYP7A1 via repression of NR0B2 and NFIL3 which are negative regulators of CYP7A1. Modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy; controls mitochondrial biogenesis and respiration by interfering with the STK11-PRKAA1/2-SIRT1-PPARGC1A signaling pathway. Represses the expression of SERPINE1/PAI1, an important modulator of cardiovascular disease and the expression of inflammatory cytokines and chemokines in macrophages. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). Plays a role in the circadian regulation of body temperature and negatively regulates thermogenic transcriptional programs in brown adipose tissue (BAT); imposes a circadian oscillation in BAT activity, increasing body temperature when awake and depressing thermogenesis during sleep. In concert with NR2E3, regulates transcriptional networks critical for photoreceptor development and function. In addition to its activity as a repressor, can also act as a transcriptional activator. In the ovarian granulosa cells acts as a transcriptional activator of STAR which plays a role in steroid biosynthesis. In collaboration with SP1, activates GJA1 transcription in a heme-independent manner."	""	"TRUE"
"5238-26_3"	"SL013928"	"PPIE"	"Peptidyl-prolyl cis-trans isomerase E"	"1"	"39692182"	"39763914"	"PPIE"	"10450"	"Q9UNP9"	""	""	""	""	""	""	""	"PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Combines RNA-binding and PPIase activities. May be involved in muscle- and brain-specific processes. May be involved in pre-mRNA splicing."	"171"	"TRUE"
"5242-37_3"	"SL007237"	"MP2K4"	"Dual specificity mitogen-activated protein kinase kinase 4"	"17"	"12020824"	"12143830"	"MAP2K4"	"6416"	"P45985"	"Apoptosis|FAS pathway and Stress induction of HSP regulation|IL-1 signaling pathway|IL-6 signaling pathway|Insulin Signaling|MAPK Cascade|MAPK signaling pathway|MicroRNAs in cardiomyocyte hypertrophy|Regulation of toll-like receptor signaling pathway|TGF beta Signaling Pathway|TNF alpha Signaling Pathway|Toll-like receptor signaling pathway|angiogenesis overview|p38 MAPK Signaling Pathway"	"CD40/CD40L signaling|CDC42 signaling events|Cellular roles of Anthrax toxin|Ceramide signaling pathway|Ephrin B reverse signaling|ErbB1 downstream signaling|Fc-epsilon receptor I signaling in mast cells|IL6-mediated signaling events|JNK signaling in the CD4+ TCR pathway|Nephrin/Neph1 signaling in the kidney podocyte|PDGFR-beta signaling pathway|RAC1 signaling pathway|Regulation of Androgen receptor activity|Regulation of p38-alpha and p38-beta|RhoA signaling pathway|Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)|Signaling events mediated by focal adhesion kinase|TRAIL signaling pathway|VEGFR3 signaling in lymphatic endothelium"	""	"FCERI mediated MAPK activation|Interleukin-1 signaling|JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1|Oxidative Stress Induced Senescence|Uptake and function of anthrax toxins"	"ADRA1A -> IL6 production|AngiopoietinR -> AP-1 signaling|CNR1/2 -> IL1B/2/4/6/10 production|CannabinoidR -> AP-1/EGR signaling|DopamineR2 -> AP-1/CREB/ELK-SRF signaling|EDG3/5 -> AP-1/ELK-SRF signaling|EDNRA/B -> vascular motility|EGFR -> AP-1/ATF2 signaling|EGFR -> AP-1/CREB/ELK-SRF/MYC signaling|EGFR/ERBB2 -> TP53 signaling|EctodysplasinR -> AP-1 signaling|EndothelinRa -> AP-1/CREB signaling|EndothelinRb -> AP-1/CREB/ELK-SRF signaling|EphrinB ->  JUN signaling|ErythropoietinR -> AP-1/CREB/MYC signaling|FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling|FibronectinR -> AP-1/ELK-SRF/SREBF signaling|FibronectinR -> NF-kB signaling|FrizzledR -> JUN/PAX2 signaling|GDNF -> HSF1 signaling|GNRHR -> ELK-SRF signaling|HGFR -> AP-1/CREB/MYC signaling|IL1R -> STAT3 signaling|NGFR -> AP-1/CEBPB/CREB/ELK-SRF/TP53 signaling|NGFR -> MEF signaling|NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling|Nociception-related DRD2 expression targets|Notch -> TCF3 signaling|PDGFR -> AP-1/MYC signaling|PTAFR -> AP-1/ATF1/CREB/ERK-SRF signaling|PTGER2/3 -> inflammation-related expression targets|Summarized nociception-related expression targets|T-cell receptor -> ATF/CREB signaling|TGFBR -> AP-1 signaling|TGFBR -> ATF/GADD/MAX/TP53 signaling|TGFBR -> CREB/ELK-SRF signaling|TGFBR -> MEF/MYOD/MYOG signaling|TLR -> AP-1 signaling|TLR4 Signaling in Leukocytes|TNFR -> AP-1/ATF/TP53 signaling|TNFR -> CREB/ELK-SRF signaling|TNFRSF1A -> AP-1/ATF/TP53 signaling|TNFRSF1A -> CREB/ELK-SRF signaling|TNFRSF6 -> DDIT3 signaling|TNFRSF6 -> HSF1 signaling|ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling|ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling|ThrombopoietinR -> SPI1 signaling|Toll-like Receptors Act through MYD88-TIRAP Signaling|VEGFR -> AP-1/CREB/MYC signaling|VEGFR -> ATF/CREB/ELK-SRF signaling|VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling|VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling"	""	""	"Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14."	"31|43|356"	"TRUE"
"5244-12_3"	"SL004716"	"JNK2"	"Mitogen-activated protein kinase 9"	"5"	"180233143"	"180292099"	"MAPK9"	"5601"	"P45984"	"B Cell Receptor Signaling Pathway|DNA damage response (only ATM dependent)|EGF/EGFR Signaling Pathway|Estrogen signaling pathway|Focal Adhesion|IL-1 signaling pathway|Insulin Signaling|MAPK signaling pathway|Prolactin Signaling Pathway|RANKL/RANK Signaling Pathway|Regulation of toll-like receptor signaling pathway|TCR Signaling Pathway|TGF Beta Signaling Pathway|TGF beta Signaling Pathway|TNF alpha Signaling Pathway|TWEAK Signaling Pathway|Toll-like receptor signaling pathway|Wnt Signaling Pathway|Wnt Signaling Pathway and Pluripotency"	"ATF-2 transcription factor network|CD40/CD40L signaling|CDC42 signaling events|Downstream signaling in naïve CD8+ T cells|ErbB1 downstream signaling|ErbB2/ErbB3 signaling events|FAS (CD95) signaling pathway|FoxO family signaling|Glucocorticoid receptor regulatory network|Glypican 3 network|IL12 signaling mediated by STAT4|IL2-mediated signaling events|Nephrin/Neph1 signaling in the kidney podocyte|Noncanonical Wnt signaling pathway|PDGFR-beta signaling pathway|RAC1 signaling pathway|Rapid glucocorticoid signaling|Regulation of retinoblastoma protein|Role of Calcineurin-dependent NFAT signaling in lymphocytes|Signaling events mediated by focal adhesion kinase|p53 pathway|p75(NTR)-mediated signaling"	""	"Activation of the AP-1 family of transcription factors|FCERI mediated MAPK activation|JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1|Oxidative Stress Induced Senescence"	"AngiopoietinR -> AP-1 signaling|CNR1/2 -> IL1B/2/4/6/10 production|CannabinoidR -> AP-1/EGR signaling|DopamineR2 -> AP-1/CREB/ELK-SRF signaling|EDG3/5 -> AP-1/ELK-SRF signaling|EGFR -> AP-1/ATF2 signaling|EGFR -> AP-1/CREB/ELK-SRF/MYC signaling|EGFR/ERBB2 -> TP53 signaling|EctodysplasinR -> AP-1 signaling|EndothelinRa -> AP-1/CREB signaling|EndothelinRb -> AP-1/CREB/ELK-SRF signaling|EphrinB ->  JUN signaling|ErythropoietinR -> AP-1/CREB/MYC signaling|FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling|FibronectinR -> AP-1/ELK-SRF/SREBF signaling|FrizzledR -> JUN/PAX2 signaling|GNRHR -> ELK-SRF signaling|HGFR -> AP-1/CREB/MYC signaling|NGFR -> AP-1/CEBPB/CREB/ELK-SRF/TP53 signaling|NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling|Nociception-related DRD2 expression targets|PDGFR -> AP-1/MYC signaling|PTAFR -> AP-1/ATF1/CREB/ERK-SRF signaling|Regulatory T-cell Differentiation|Summarized nociception-related expression targets|T-cell Receptor Signaling|T-cell-Dependent B-cell Activation|T-cell-Independent B-cell Activation|TGFBR -> AP-1 signaling|TLR -> AP-1 signaling|TNFR -> AP-1/ATF/TP53 signaling|TNFR -> CREB/ELK-SRF signaling|TNFRSF1A -> AP-1/ATF/TP53 signaling|TNFRSF1A -> CREB/ELK-SRF signaling|Th1 Cell Differentiation|Th2 Cell Differentiation|ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling|ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling|VEGFR -> AP-1/CREB/MYC signaling|VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling|VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling"	""	""	"Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692)."	""	"TRUE"
"5245-40_5"	"SL016549"	"AMPK a2b2g1"	"AMP Kinase (alpha2beta2gamma1)"	"1|1|12"	"56645322|147155106|49002274"	"56715335|147172550|49019197"	"PRKAA2|PRKAB2|PRKAG1"	"5563|5565|5571"	"P54646|O43741|P54619"	"AMPK signaling|Energy Metabolism|TOR signaling"	""	""	"AMPK inhibits chREBP transcriptional activation activity|Activation of PPARGC1A (PGC-1alpha) by phosphorylation|Import of palmitoyl-CoA into the mitochondrial matrix|Regulation of AMPK activity via LKB1|Regulation of Rheb GTPase activity by AMPK|TP53 Regulates Metabolic Genes|Translocation of GLUT4 to the plasma membrane"	""	""	""	"Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. Involved in insulin receptor/INSR internalization (PubMed:25687571). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2. In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1. AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it. May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it. Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1. Plays an important role in the differential regulation of pro-autophagy (composed of PIK3C3, BECN1, PIK3R4 and UVRAG or ATG14) and non-autophagy (composed of PIK3C3, BECN1 and PIK3R4) complexes, in response to glucose starvation. Can inhibit the non-autophagy complex by phosphorylating PIK3C3 and can activate the pro-autophagy complex by phosphorylating BECN1 (By similarity).|Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).|AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive."	""	"TRUE"
"5246-64_3"	"SL005730"	"cGMP-stimulated PDE"	"cGMP-dependent 3',5'-cyclic phosphodiesterase"	"11"	"72576141"	"72674591"	"PDE2A"	"5138"	"O00408"	""	""	""	"G alpha (s) signalling events|cGMP effects"	""	""	""	"Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes."	""	"TRUE"
"5248-68_2"	"SL005793"	"Cyclophilin F"	"Peptidyl-prolyl cis-trans isomerase F, mitochondrial"	"10"	"79347469"	"79355337"	"PPIF"	"10105"	"P30405"	"Epithelium TarBase|Leukocyte TarBase|Lymphocyte TarBase|Muscle cell TarBase"	""	""	""	""	""	""	"PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis."	""	"TRUE"
"5249-31_3"	"SL016566"	"DRAK2"	"Serine/threonine-protein kinase 17B"	"2"	"196133566"	"196176503"	"STK17B"	"9262"	"O94768"	""	""	""	""	""	""	""	"Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis."	"333"	"TRUE"
"5250-53_3"	"SL010928"	"IMDH2"	"Inosine-5'-monophosphate dehydrogenase 2"	"3"	"49024325"	"49029408"	"IMPDH2"	"3615"	"P12268"	""	""	""	""	""	"thioguanine|VX-944|pegintron/ribavirin|interferon alfa-2b/ribavirin|mycophenolate mofetil|mycophenolic acid|ribavirin"	""	"Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors."	"237"	"TRUE"
"5252-33_3"	"SL016555"	"PDE11"	"Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A"	"2"	"177623252"	"178108339"	"PDE11A"	"50940"	"Q9HCR9"	""	""	""	"G alpha (s) signalling events|cGMP effects"	""	"dyphylline|nitroglycerin|aminophylline|dipyridamole|tolbutamide|tadalafil|theophylline|pentoxifylline"	""	"Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively."	""	"TRUE"
"5254-69_3"	"SL016553"	"PDE3A"	"cGMP-inhibited 3',5'-cyclic phosphodiesterase A"	"12"	"20369245"	"20684381"	"PDE3A"	"5139"	"Q14432"	"Lymphocyte TarBase|Muscle cell TarBase"	""	""	"G alpha (s) signalling events|cGMP effects"	""	"dyphylline|nitroglycerin|medorinone|aminophylline|anagrelide|enoximone|milrinone|cilostazol|dipyridamole|amrinone|tolbutamide|theophylline|pentoxifylline"	""	"Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes."	""	"TRUE"
"5255-22_3"	"SL011404"	"PDE4D"	"cAMP-specific 3',5'-cyclic phosphodiesterase 4D"	"5"	"58969038"	"60522120"	"PDE4D"	"5144"	"Q08499"	"G Protein Signaling Pathways|Myometrial Relaxation and Contraction Pathways|TSH signaling pathway"	""	"3',5'-cyclic AMP degradation"	"DARPP-32 events|G alpha (s) signalling events"	""	"dyphylline|nitroglycerin|caffeine/ergotamine|arofylline|tetomilast|L 869298|aminophylline|anagrelide|cilomilast|milrinone|dipyridamole|L-826|141|ketotifen|roflumilast|tolbutamide|theophylline|pentoxifylline|caffeine"	""	"Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes."	""	"TRUE"
"5256-86_3"	"SL011405"	"PDE5A"	"cGMP-specific 3',5'-cyclic phosphodiesterase"	"4"	"119494395"	"119628991"	"PDE5A"	"8654"	"O76074"	""	""	"3',5'-cyclic GMP degradation"	"cGMP effects"	"ADRB1/3 -> vasodilation|Summarized vascular motility pathway"	"dyphylline|nitroglycerin|udenafil|avanafil|aspirin/dipyridamole/telmisartan|aminophylline|sildenafil|dipyridamole|aspirin/dipyridamole|vardenafil|tolbutamide|tadalafil|theophylline|pentoxifylline"	"diagnosis"	"Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:9714779, PubMed:15489334). Specifically regulates nitric-oxide-generated cGMP (PubMed:15489334)."	"390"	"TRUE"
"5259-2_3"	"SL016567"	"TAK1-TAB1"	"Mitogen-activated protein kinase kinase kinase 7:TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 fusion"	"22|6"	"39399741|90513573"	"39437060|90587045"	"MAP3K7|TAB1"	"6885|10454"	"O43318|Q15750"	"B Cell Receptor Signaling Pathway|DNA damage response (only ATM dependent)|EBV LMP1 signaling|FAS pathway and Stress induction of HSP regulation|IL-1 signaling pathway|Insulin Signaling|MAPK signaling pathway|NLR proteins|RANKL/RANK Signaling Pathway|Regulation of toll-like receptor signaling pathway|TCR Signaling Pathway|TGF beta Signaling Pathway|TNF alpha Signaling Pathway|TWEAK Signaling Pathway|Toll-like receptor signaling pathway|Wnt Signaling Pathway|Wnt Signaling Pathway and Pluripotency|angiogenesis overview|p38 MAPK Signaling Pathway"	"BCR signaling pathway|BMP receptor signaling|C-MYB transcription factor network|Ephrin B reverse signaling|IL1-mediated signaling events|JNK signaling in the CD4+ TCR pathway|Noncanonical Wnt signaling pathway|Presenilin action in Notch and Wnt signaling|TGF-beta receptor signaling|TNF receptor signaling pathway|p38 MAPK signaling pathway"	""	"Activation of NF-kappaB in B cells|CLEC7A (Dectin-1) signaling|Ca2+ pathway|Downstream TCR signaling|FCERI mediated NF-kB activation|IRAK2 mediated activation of TAK1 complex|IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation|Interleukin-1 signaling|JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1|NOD1/2 Signaling Pathway|TAK1 activates NFkB by phosphorylation and activation of IKKs complex|TRAF6 mediated induction of TAK1 complex|activated TAK1 mediates p38 MAPK activation"	"Activation of Immunoglobulin Class-Switch Recombination|Antiviral Signaling through Pattern Recognition Receptors|Apoptosis|B-cell receptor -> NF-kB signaling|CD38 ->  NF-kB signaling|CD8+ T-cell Activation|DDR1 -> NF-kB signaling|EctodysplasinR -> LEF1 signaling|EphrinB ->  JUN signaling|IL1R -> NF-kB signaling|NOD-like Receptors in Pathogen Recognition|Nociception-related IL1B expression targets|Peripheral T-cell Tolerance Overview|Regulatory T-cell Differentiation|T-cell Receptor Signaling|T-cell receptor -> NF-kB signaling|T-cell-Dependent B-cell Activation|T-cell-Independent B-cell Activation|TLR -> AP-1 signaling|TLR1/2/6 -> NF-kB signaling|TLR4 Signaling in Leukocytes|TLR4/5/7/9 -> NF-kB signaling|TNFR -> NF-kB signaling|Th1 Cell Differentiation|Th17 Cell Differentiation|Th2 Cell Differentiation|Toll-like Receptors Act through MYD88 Signaling|Toll-like Receptors Act through MYD88-TIRAP Signaling|V(D)J Recombination Activation"	""	""	"Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity.|May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis."	""	"TRUE"
"5260-80_3"	"SL007181"	"TYK2"	"Non-receptor tyrosine-protein kinase TYK2"	"19"	"10350529"	"10380676"	"TYK2"	"7297"	"P29597"	"IL-4 signaling pathway|IL-6 signaling pathway"	"IL12-mediated signaling events|IL23-mediated signaling events|IL27-mediated signaling events|IL6-mediated signaling events|Signaling events mediated by PTP1B"	""	"ERK1 activation|ERK2 activation|Interferon alpha/beta signaling|Interleukin-6 signaling|Regulation of IFNA signaling"	"BradykininR -> STAT3 signaling|CD8+ T-cell Activation|CNTFR -> STAT3 signaling|CSF1R -> STAT signaling|CSF3R -> STAT signaling|GHR -> STAT signaling|IFNAR -> STAT signaling|IL10R -> STAT signaling|IL12R -> NF-kB/NFATC signaling|IL12R -> STAT signaling|IL13R -> STAT signaling|IL22R -> STAT3 signaling|IL6R -> STAT signaling|LIFR -> STAT5A signaling|Nociception-related IL6 expression targets|PTAFR -> STAT3 signaling|Th1 Cell Differentiation|Th17 Cell Differentiation|ThrombinR -> STAT1 signaling|ThrombopoietinR -> STAT signaling|UrokinaseR -> ELK-SRF signaling|UrokinaseR -> STAT signaling|VEGFR -> STAT signaling"	""	""	"Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain."	"333"	"TRUE"
"5261-13_3"	"SL010488"	"ABL2"	"Abelson tyrosine-protein kinase 2"	"1"	"179099327"	"179229684"	"ABL2"	"27"	"P42684"	""	""	""	"Role of Abl in Robo-Slit signaling"	""	""	""	"Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1."	"333"	"TRUE"
"5262-57_3"	"SL014470"	"BCAR3"	"Breast cancer anti-estrogen resistance protein 3"	"1"	"93561786"	"93847150"	"BCAR3"	"8412"	"O75815"	""	"Regulation of CDC42 activity"	""	""	""	""	""	"May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins."	"333"	"TRUE"
"5264-65_3"	"SL003520"	"calreticulin"	"Calreticulin"	"19"	"12938578"	"12944489"	"CALR"	"811"	"P27797"	"Androgen receptor signaling pathway|Calcium Regulation in the Cardiac Cell"	""	""	"ATF6-alpha activates chaperone genes|Antigen Presentation: Folding, assembly and peptide loading of class I MHC|Assembly of Viral Components at the Budding Site|Calnexin/calreticulin cycle|ER-Phagosome pathway|Scavenging by Class A Receptors|Scavenging by Class F Receptors"	"Co-Translational ER Protein Import|MHC1-Mediated Antigen Presentation|Presentation of Endogenous Peptide Antigen"	""	"unspecified application"	"Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity)."	""	"TRUE"
"5265-12_3"	"SL005725"	"GRB2-related adapter protein 2"	"GRB2-related adapter protein 2"	"22"	"39901082"	"39973721"	"GRAP2"	"9402"	"O75791"	"TCR Signaling Pathway"	"JNK signaling in the CD4+ TCR pathway|Signaling events mediated by Stem cell factor receptor (c-Kit)|TCR signaling in naïve CD4+ T cells|TCR signaling in naïve CD8+ T cells"	""	"CD28 co-stimulation|DAP12 signaling|FCERI mediated Ca+2 mobilization|FCERI mediated MAPK activation|Generation of second messenger molecules|Signaling by SCF-KIT"	"Regulatory T-cell Differentiation|T-cell Receptor Signaling|Th1 Cell Differentiation|Th17 Cell Differentiation|Th2 Cell Differentiation"	""	""	"Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc."	""	"TRUE"
"5268-49_3"	"SL003331"	"MMP-16"	"Matrix metalloproteinase-16"	"8"	"88032009"	"88328025"	"MMP16"	"4325"	"P51512"	"Matrix Metalloproteinases"	""	""	"Activation of Matrix Metalloproteinases"	""	"marimastat"	""	"Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells."	""	"TRUE"
"5272-55_2"	"SL014469"	"SHC1"	"SHC-transforming protein 1"	"1"	"154962298"	"154974395"	"SHC1"	"6464"	"P29353"	"Alpha 6 Beta 4 signaling pathway|B Cell Receptor Signaling Pathway|DNA damage response (only ATM dependent)|EGF/EGFR Signaling Pathway|EPO Receptor Signaling|Focal Adhesion|IL-2 Signaling pathway|IL-3 Signaling Pathway|IL-4 signaling pathway|IL-5 signaling pathway|IL-6 signaling pathway|Insulin Signaling|Integrin-mediated cell adhesion|Kit receptor signaling pathway|Leptin signaling pathway|Prolactin Signaling Pathway|TCR Signaling Pathway|TGF beta Signaling Pathway|angiogenesis overview|p38 MAPK Signaling Pathway"	"Angiopoietin receptor Tie2-mediated signaling|BCR signaling pathway|EGF receptor (ErbB1) signaling pathway|EGFR-dependent Endothelin signaling events|EPHA2 forward signaling|EPHB forward signaling|EPO signaling pathway|ErbB2/ErbB3 signaling events|ErbB4 signaling events|FGF signaling pathway|Fc-epsilon receptor I signaling in mast cells|GMCSF-mediated signaling events|IGF1 pathway|IL2 signaling events mediated by PI3K|IL2 signaling events mediated by STAT5|IL2-mediated signaling events|IL3-mediated signaling events|IL4-mediated signaling events|Insulin Pathway|Internalization of ErbB1|Neurotrophic factor-mediated Trk receptor signaling|PDGFR-alpha signaling pathway|PDGFR-beta signaling pathway|Plasma membrane estrogen receptor signaling|SHP2 signaling|Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)|Signaling events mediated by PTP1B|Signaling events mediated by Stem cell factor receptor (c-Kit)|Signaling events mediated by TCPTP|Signaling events regulated by Ret tyrosine kinase|TCR signaling in naïve CD4+ T cells|TCR signaling in naïve CD8+ T cells|TGF-beta receptor signaling|Trk receptor signaling mediated by PI3K and PLC-gamma|VEGFR3 signaling in lymphatic endothelium|a6b1 and a6b4 Integrin signaling|p75(NTR)-mediated signaling"	""	"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers|Constitutive Signaling by EGFRvIII|Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants|DAP12 signaling|FCERI mediated Ca+2 mobilization|FCERI mediated MAPK activation|G beta:gamma signalling through PI3Kgamma|GPVI-mediated activation cascade|Integrin alphaIIb beta3 signaling|Interleukin receptor SHC signaling|Interleukin-2 signaling|Interleukin-3, 5 and GM-CSF signaling|Role of LAT2/NTAL/LAB on calcium mobilization|SHC activation|SHC-mediated cascade:FGFR1|SHC-mediated cascade:FGFR2|SHC-mediated cascade:FGFR3|SHC-mediated cascade:FGFR4|SHC-mediated signalling|SHC-related events triggered by IGF1R|SHC1 events in EGFR signaling|SHC1 events in ERBB2 signaling|SHC1 events in ERBB4 signaling|Signal attenuation|Signalling to RAS|Tie2 Signaling|XBP1(S) activates chaperone genes"	"CHRM1 -> IL2 production|CholinergicRm -> CREB/ELK-SRF signaling|DDR1 -> NF-kB signaling|DopamineR2 -> AP-1/CREB/ELK-SRF signaling|EDG2 -> ELK-SRF signaling|EGFR -> AP-1/ATF2 signaling|EGFR -> AP-1/CREB/ELK-SRF/MYC signaling|EGFR -> CTNND signaling|EGFR -> NCOR2 signaling|EGFR -> SMAD1 signaling|EGFR/ERBB -> STAT signaling|EGFR/ERBB2 -> CTNNB signaling|EGFR/ERBB2 -> HIF1A signaling|EGFR/ERBB2 -> TP53 signaling|ERBB2/3 -> EP300/ETS/ETV/SP1 signaling|ErythropoietinR -> ELK-SRF/FOS signaling|FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling|FGFR -> RUNX2 signaling|FcIgER -> ELK-SRF signaling|FibronectinR -> AP-1/ELK-SRF/SREBF signaling|GDNF -> HSF1 signaling|GHR -> ELK-SRF/MYC signaling|GRM1/5 -> CREB signaling|HGFR -> AP-1/CREB/MYC signaling|IGF1R -> ELK-SRF/HIF1A/MYC/SREBF signaling|IL2R -> ELK-SRF/MYC signaling|IL4R -> ELK-SRF/HMGY signaling|InsulinR -> ELK-SRF/SREBF signaling|KIT -> MITF signaling|Model of T-cell Maturation|NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling|NTRK1/2/3 -> acetylcholine production|NURD Chromatin Remodeling|NeurotensinR -> ELK-SRF/AP-1/EGR signaling|Nociception-related DRD2 expression targets|Nociception-related NTSR1 expression targets|PDGFR -> AP-1/MYC signaling|Regulation of calcium flux|Summarized nociception-related expression targets|ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling|ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling|ThrombopoietinR -> SP1 signaling|ThrombopoietinR -> SPI1 signaling|UrokinaseR -> ELK-SRF signaling|VEGFR -> AP-1/CREB/MYC signaling|VEGFR -> ATF/CREB/ELK-SRF signaling|VEGFR -> NFATC signaling|VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling|VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling"	""	""	"Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis."	""	"FALSE"
"5280-68_5"	"SL016563"	"GHC2"	"Mitochondrial glutamate carrier 2"	"22"	"17563439"	"17590994"	"SLC25A18"	"83733"	"Q9H1K4"	""	""	""	""	""	""	""	"Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+)."	""	"TRUE"
"5301-7_3"	"SL000406"	"Eotaxin"	"Eotaxin"	"17"	"34285668"	"34288334"	"CCL11"	"6356"	"P51671"	""	"CXCR3-mediated signaling events|IL4-mediated signaling events"	""	"Chemokine receptors bind chemokines"	"CCR2/5 -> STAT signaling|CCR5 -> TP53 signaling"	""	"unspecified application"	"In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3."	""	"TRUE"
"5307-12_3"	"SL004400"	"Coagulation Factor IXab"	"Coagulation factor IXab"	"X"	"139530758"	"139563458"	"F9"	"2158"	"P00740"	"Blood Clotting Cascade|Complement and Coagulation Cascades"	""	""	"Extrinsic Pathway of Fibrin Clot Formation|Gamma-carboxylation of protein precursors|Intrinsic Pathway of Fibrin Clot Formation|Removal of aminoterminal propeptides from gamma-carboxylated proteins|Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus"	"Coagulation Cascade|Vitamin K metabolism"	"moroctocog alfa|activated recombinant human factor VII"	""	"Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa."	""	"TRUE"
"5308-89_2"	"SL000401"	"Elastase"	"Neutrophil elastase"	"19"	"851014"	"856285"	"ELANE"	"1991"	"P08246"	""	"C-MYB transcription factor network|Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling"	""	"Activation of Matrix Metalloproteinases|Collagen degradation|Degradation of the extracellular matrix"	""	"SERPINA1"	"diagnosis|efficacy"	"Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis."	""	"TRUE"
"5312-49_3"	"SL000277"	"Apo E2"	"Apolipoprotein E (isoform E2)"	"19"	"44905754"	"44909393"	"APOE"	"348"	"P02649"	"Alzheimers Disease|Statin Pathway|Vitamin B12 Metabolism"	""	""	"Chylomicron-mediated lipid transport|HDL-mediated lipid transport|Retinoid metabolism and transport|Scavenging by Class A Receptors"	""	""	"diagnosis|efficacy|prognosis|unspecified application"	"Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues."	"306"	"TRUE"
"5316-54_3"	"SL000558"	"Prothrombin"	"Prothrombin"	"11"	"46719180"	"46739506"	"F2"	"2147"	"P00734"	"Blood Clotting Cascade|Complement and Coagulation Cascades|Folate Metabolism|Regulation of Actin Cytoskeleton|Selenium Pathway|Vitamin B12 Metabolism|angiogenesis overview"	"Angiopoietin receptor Tie2-mediated signaling|FOXA2 and FOXA3 transcription factor networks|PAR1-mediated thrombin signaling events|PAR4-mediated thrombin signaling events|Syndecan-4-mediated signaling events|Thrombin/protease-activated receptor (PAR) pathway"	""	"Cell surface interactions at the vascular wall|Common Pathway of Fibrin Clot Formation|G alpha (q) signalling events|Gamma-carboxylation of protein precursors|Intrinsic Pathway of Fibrin Clot Formation|Peptide ligand-binding receptors|Platelet Aggregation (Plug Formation)|Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)|Removal of aminoterminal propeptides from gamma-carboxylated proteins|Thrombin signalling through proteinase activated receptors (PARs)|Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus"	"Coagulation Cascade|ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling|ThrombinR -> NF-kB signaling|ThrombinR -> STAT1 signaling|Vitamin K metabolism"	"enoxaparin|desirudin|dabigatran etexilate|Fibrinogen|ximelagatran|antithrombin alfa|aspirin/dabigatran etexilate|dabigatran|argatroban|bivalirudin|lepirudin"	"diagnosis|unspecified application"	"Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing."	""	"TRUE"
"5317-3_3"	"SL007195"	"CD70"	"CD70 antigen"	"19"	"6583183"	"6604103"	"CD70"	"970"	"P32970"	"NA"	"NA"	"NA"	"NA"	"NA"	""	"diagnosis"	"Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells."	""	"TRUE"
"5335-73_3"	"SL003647"	"annexin VI"	"Annexin A6"	"5"	"151100712"	"151157882"	"ANXA6"	"309"	"P08133"	"Calcium Regulation in the Cardiac Cell|Prostaglandin Synthesis and Regulation"	""	""	"Muscle contraction"	""	""	""	"May associate with CD21. May regulate the release of Ca(2+) from intracellular stores."	""	"TRUE"
"5337-64_3"	"SL004131"	"B7-2"	"T-lymphocyte activation antigen CD86"	"3"	"122055366"	"122121139"	"CD86"	"942"	"P42081"	"IL-3 Signaling Pathway|Inflammatory Response Pathway|Regulation of toll-like receptor signaling pathway|Toll-like receptor signaling pathway"	"IL12 signaling mediated by STAT4|TCR signaling in naïve CD4+ T cells|TCR signaling in naïve CD8+ T cells"	""	"CD28 co-stimulation|CD28 dependent PI3K/Akt signaling|CD28 dependent Vav1 pathway|CTLA4 inhibitory signaling|Constitutive Signaling by Aberrant PI3K in Cancer|PIP3 activates AKT signaling"	"CD8+ T-cell Activation|Peripheral T-cell Tolerance Overview|Regulatory T-cell Differentiation|T-cell Receptor Signaling|T-cell receptor -> AP-1 signaling|T-cell receptor -> ATF/CREB signaling|T-cell receptor -> CREBBP signaling|T-cell receptor -> NF-kB signaling|T-cell receptor -> NFATC signaling|T-cell receptor -> STAT signaling|TLR4 Signaling in Leukocytes|Th1 Cell Differentiation|Th17 Cell Differentiation|Th2 Cell Differentiation"	"abatacept|belatacept|abatacept/methotrexate"	"efficacy|prognosis"	"Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation."	""	"TRUE"
"5339-49_3"	"SL004477"	"calgranulin B"	"Protein S100-A9"	"1"	"153357854"	"153361027"	"S100A9"	"6280"	"P06702"	""	"Endogenous TLR signaling"	""	""	""	""	"diagnosis|unspecified application"	"S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinfammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. Can act as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread. Has transnitrosylase activity; in oxidatively-modified low-densitity lipoprotein (LDL(ox))-induced S-nitrosylation of GAPDH on 'Cys-247' proposed to transfer the NO moiety from NOS2/iNOS to GAPDH via its own S-nitrosylated Cys-3. The iNOS-S100A8/A9 transnitrosylase complex is proposed to also direct selective inflammatory stimulus-dependent S-nitrosylation of multiple targets such as ANXA5, EZR, MSN and VIM by recognizing a [IL]-x-C-x-x-[DE] motif."	""	"TRUE"
"5340-24_3"	"SL003717"	"Caspase-10"	"Caspase-10"	"2"	"201182881"	"201229406"	"CASP10"	"843"	"Q92851"	"Apoptosis|Apoptosis Modulation and Signaling|FAS pathway and Stress induction of HSP regulation"	"Caspase Cascade in Apoptosis|Direct p53 effectors|FAS (CD95) signaling pathway|TRAIL signaling pathway"	""	"FasL/ CD95L signaling|NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10|TRAIL signaling"	"Apoptosis|Cell Death Mediated by Cytotoxic Cells|Peripheral T-cell Tolerance Overview"	""	""	"Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC."	""	"TRUE"
"5343-74_3"	"SL008703"	"CBPE"	"Carboxypeptidase E"	"4"	"165361194"	"165498320"	"CPE"	"1363"	"P16870"	""	"Arf6 trafficking events"	""	"Insulin processing"	""	""	""	"Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin."	""	"TRUE"
"5345-51_3"	"SL006675"	"CKAP2"	"Cytoskeleton-associated protein 2"	"13"	"52455429"	"52476628"	"CKAP2"	"26586"	"Q8WWK9"	""	""	""	""	""	""	""	"Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity)."	""	"TRUE"
"5346-24_3"	"SL011808"	"CPNE1"	"Copine-1"	"20"	"35626031"	"35664956"	"CPNE1"	"8904"	"Q99829"	""	""	""	"Glycerophospholipid biosynthesis"	""	""	""	"Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes (PubMed:14674885). Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner (PubMed:14674885). Exhibits calcium-dependent phospholipid binding properties (PubMed:9430674, PubMed:19539605). Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner (PubMed:23263657, PubMed:25450385). May recruit target proteins to the cell membrane in a calcium-dependent manner (PubMed:12522145). May function in membrane trafficking (PubMed:9430674). Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit (PubMed:18212740). Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL (PubMed:18212740)."	"50|244"	"TRUE"
"5347-59_3"	"SL000130"	"Cyclin B1"	"G2/mitotic-specific cyclin-B1"	"5"	"69167010"	"69178245"	"CCNB1"	"891"	"P14635"	"AMPK signaling|Cell cycle|DNA damage response|G1 to S cell cycle control|miRNA regulation of DNA Damage Response"	"C-MYB transcription factor network|Direct p53 effectors|FOXM1 transcription factor network|FoxO family signaling|PLK1 signaling events|Validated targets of C-MYC transcriptional activation|p73 transcription factor network"	""	"APC/C:Cdc20 mediated degradation of Cyclin B|Activation of NIMA Kinases NEK9, NEK6, NEK7|Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex|Condensation of Prometaphase Chromosomes|Condensation of Prophase Chromosomes|Cyclin A/B1 associated events during G2/M transition|Depolymerisation of the Nuclear Lamina|E2F-enabled inhibition of pre-replication complex formation|G2/M DNA replication checkpoint|Golgi Cisternae Pericentriolar Stack Reorganization|MASTL Facilitates Mitotic Progression|Nuclear Pore Complex (NPC) Disassembly|Phosphorylation of Emi1|Phosphorylation of the APC/C|Polo-like kinase mediated events|Recruitment of NuMA to mitotic centrosomes|Regulation of APC/C activators between G1/S and early anaphase|Regulation of PLK1 Activity at G2/M Transition|Resolution of Sister Chromatid Cohesion"	"Cell Cycle"	""	""	"Essential for the control of the cell cycle at the G2/M (mitosis) transition."	""	"TRUE"
"5349-69_3"	"SL006970"	"DLL1"	"Delta-like protein 1"	"6"	"170282206"	"170306565"	"DLL1"	"28514"	"O00548"	"Neural Crest Differentiation|Notch Signaling Pathway"	"Notch signaling pathway|Presenilin action in Notch and Wnt signaling"	""	"Activated NOTCH1 Transmits Signal to the Nucleus|Constitutive Signaling by NOTCH1 HD Domain Mutants|Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants|Constitutive Signaling by NOTCH1 PEST Domain Mutants|Constitutive Signaling by NOTCH1 t(7|NOTCH2 Activation and Transmission of Signal to the Nucleus|Signaling by NOTCH3|Signaling by NOTCH4"	"Adherens Junction Assembly (Cadherins)|Notch -> EP300/ASCL signaling|Notch -> LEF1 signaling|Notch -> MEF/MYOD signaling|Notch -> NF-kB signaling|Notch -> RBPJ/HES/HEY signaling|Notch -> SMAD3 signaling|Notch -> TCF3 signaling"	""	""	"Transmembrane ligand protein of NOTCH1, NOTCH2 and NOTCH3 receptors that binds the extracellular domain (ECD) of Notch receptor in a cis and trans fashion manner (PubMed:11006133). Following transinteraction, ligand cells produce mechanical force that depends of a clathrin-mediated endocytosis, requiring ligand ubiquitination, EPN1 interaction, and actin polymerisation; these events promote Notch receptor extracellular domain (NECD) transendocytosis and triggers Notch signaling through induction of cleavage, hyperphosphorylation, and nuclear accumulation of the intracellular domain of Notch receptors (NICD) (By similarity). Is required for embryonic development and maintenance of adult stem cells in many different tissues and immune systeme; the DLL1-induced Notch signaling is mediated through an intercellular communication that regulates cell lineage, cell specification, cell patterning and morphogenesis through effects on differentiation and proliferation (PubMed:11581320). Plays a role in brain development at different level, namely by regulating neuronal differentiation of neural precursor cells via cell-cell interaction, most likely through the lateral inhibitory system in an endogenous level dependent-manner. During neocortex development, Dll1-Notch signaling transmission is mediated by dynamic interactions between intermediate neurogenic progenitors and radial glia; the cell-cell interactions are mediated via dynamic and transient elongation processes, likely to reactivate/maintain Notch activity in neighboring progenitors, and coordinate progenitor cell division and differentiation across radial and zonal boundaries. During cerebellar development, regulates Bergmann glial monolayer formation and its morphological maturation through a Notch signaling pathway. At the retina and spinal cord level, regulates neurogenesis by preventing the premature differentiation of neural progenitors and also by maintaining progenitors in spinal cord through Notch signaling pathway. Also controls neurogenesis of the neural tube in a progenitor domain-specific fashion along the dorsoventral axis. Maintains quiescence of neural stem cells and plays a role as a fate determinant that segregates asymmetrically to one daughter cell during neural stem cells mitosis, resulting in neuronal differentiation in Dll1-inheriting cell. Plays a role in immune systeme development, namely the development of all T cells and marginal zone (MZ) B cells (By similarity). Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor (PubMed:11581320). Also plays a role during muscle development. During early development, inhibits myoblasts differentiation from the medial dermomyotomal lip and later regulates progenitor cell differentiation. Directly modulates cell adhesion and basal lamina formation in satellite cells through Notch signaling. Maintains myogenic progenitors pool by suppressing differentiation through down-regulation of MYOD1 and is required for satellite cell homing and PAX7 expression. During craniofacial and trunk myogenesis suppresses differentiation of cranial mesoderm-derived and somite-derived muscle via MYOD1 regulation but in cranial mesoderm-derived progenitors, is neither required for satellite cell homing nor for PAX7 expression. Also plays a role during pancreatic cell development. During type B pancreatic cell development, may be involved in the initiation of proximodistal patterning in the early pancreatic epithelium. Stimulates multipotent pancreatic progenitor cells proliferation and pancreatic growth by maintaining HES1 expression and PTF1A protein levels. During fetal stages of development, is required to maintain arterial identity and the responsiveness of arterial endothelial cells for VEGFA through regulation of KDR activation and NRP1 expression. Controls sprouting angiogenesis and subsequent vertical branch formation througth regulation on tip cell differentiation. Negatively regulates goblet cell differentiation in intestine and controls secretory fat commitment through lateral inhibition in small intestine. Plays a role during inner ear development; negatively regulates auditory hair cell differentiation. Plays a role during nephron development through Notch signaling pathway. Regulates growth, blood pressure and energy homeostasis (By similarity)."	""	"TRUE"
"5351-52_3"	"SL004891"	"hnRNP A2/B1"	"Heterogeneous nuclear ribonucleoproteins A2/B1"	"7"	"26189927"	"26201529"	"HNRNPA2B1"	"3181"	"P22626"	"mRNA processing"	""	""	"Processing of Capped Intron-Containing Pre-mRNA|mRNA Splicing - Major Pathway"	""	""	""	"Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680)."	""	"TRUE"
"5352-11_3"	"SL004145"	"HVEM"	"Tumor necrosis factor receptor superfamily member 14"	"1"	"2555639"	"2565622"	"TNFRSF14"	"8764"	"Q92956"	""	""	""	"Costimulation by the CD28 family"	"Peripheral T-cell Tolerance Overview|TNFR -> AP-1/ATF/TP53 signaling|TNFR -> CREB/ELK-SRF signaling|TNFR -> NF-kB signaling"	""	""	"Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells."	""	"TRUE"
"5354-11_3"	"SL000655"	"Keratin 18"	"Keratin, type I cytoskeletal 18"	"12"	"52948871"	"52952901"	"KRT18"	"3875"	"P05783"	""	"Caspase Cascade in Apoptosis"	""	""	""	""	"efficacy"	"Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection."	""	"TRUE"
"5355-69_3"	"SL004648"	"LIGHT"	"Tumor necrosis factor ligand superfamily member 14"	"19"	"6661253"	"6670588"	"TNFSF14"	"8740"	"O43557"	""	""	""	""	"TNFR -> AP-1/ATF/TP53 signaling|TNFR -> CREB/ELK-SRF signaling|TNFR -> NF-kB signaling"	""	""	"Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus."	""	"TRUE"
"5356-2_3"	"SL003080"	"MIF"	"Macrophage migration inhibitory factor"	"22"	"23894004"	"23895227"	"MIF"	"4282"	"P14174"	"Adipogenesis"	""	""	""	""	""	"diagnosis|prognosis|response to therapy"	"Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity."	"8"	"TRUE"
"5357-60_3"	"SL014113"	"NLGNX"	"Neuroligin-4, X-linked"	"X"	"5840637"	"6228863"	"NLGN4X"	"57502"	"Q8N0W4"	""	""	""	""	""	""	""	"Putative neuronal cell surface protein involved in cell-cell-interactions."	""	"TRUE"
"5358-3_3"	"SL008574"	"OMD"	"Osteomodulin"	"9"	"92414245"	"92424461"	"OMD"	"4958"	"Q99983"	""	""	""	"Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)|Defective CHST6 causes MCDC1|Keratan sulfate biosynthesis|Keratan sulfate degradation"	""	""	""	"May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin (By similarity)."	""	"TRUE"
"5359-65_3"	"SL002702"	"PIM1"	"Serine/threonine-protein kinase pim-1"	"6"	"37170203"	"37175426"	"PIM1"	"5292"	"P11309"	""	"C-MYB transcription factor network|GMCSF-mediated signaling events|IL3-mediated signaling events|IL5-mediated signaling events|Role of Calcineurin-dependent NFAT signaling in lymphocytes|Validated targets of C-MYC transcriptional activation"	""	""	""	""	"disease progression|prognosis"	"Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Phosphorylation of MAP3K5, an other proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis. Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C. Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. Promote cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels. Phosphorylation of CDKN1B,induces 14-3-3-proteins binding, nuclear export and proteasome-dependent degradation. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis."	""	"TRUE"
"5363-51_3"	"SL010470"	"Semaphorin 3E"	"Semaphorin-3E"	"7"	"83363906"	"83649010"	"SEMA3E"	"9723"	"O15041"	""	"Plexin-D1 Signaling"	""	"Other semaphorin interactions"	""	""	""	"Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation (By similarity)."	"57|153|166"	"TRUE"
"5364-7_3"	"SL007336"	"SET"	"Protein SET"	"9"	"128683424"	"128696400"	"SET"	"6418"	"Q01105"	""	"Validated nuclear estrogen receptor alpha network"	""	"Condensation of Prophase Chromosomes|HuR stabilizes mRNA"	"Cell Death Mediated by Cytotoxic Cells"	""	"prognosis"	"Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher."	""	"TRUE"
"5383-14_3"	"SL004671"	"BAFF Receptor"	"Tumor necrosis factor receptor superfamily member 13C"	"22"	"41922023"	"41926818"	"TNFRSF13C"	"115650"	"Q96RJ3"	""	""	""	""	"Activation of Immunoglobulin Class-Switch Recombination|T-cell-Independent B-cell Activation"	""	""	"B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response."	""	"TRUE"
"5384-67_3"	"SL016130"	"BRF-1"	"Transcription factor IIIB 90 kDa subunit"	"14"	"105209286"	"105315589"	"BRF1"	"2972"	"Q92994"	""	""	""	"RNA Polymerase III Abortive And Retractive Initiation|RNA Polymerase III Transcription Initiation From Type 1 Promoter|RNA Polymerase III Transcription Initiation From Type 2 Promoter"	"rRNA Transcription and Processing|tRNA Transcription and Processing"	""	""	"General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter."	""	"TRUE"
"5400-52_3"	"SL003184"	"sLeptin R"	"Leptin receptor"	"1"	"65420652"	"65641559"	"LEPR"	"3953"	"P48357"	"AMPK signaling|Leptin signaling pathway"	"Signaling events mediated by PTP1B"	""	"Signaling by Leptin"	""	"recombinant-methionyl human leptin"	"prognosis"	"Receptor for hormone LEP/leptin (Probable) (PubMed:22405007). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (By similarity) (PubMed:9537324). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (PubMed:25060689, PubMed:12504075, PubMed:8805376). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T -ells. Leptin increases Th1 and suppresses Th2 cytokine production (By similarity)."	"5|287|325|424"	"TRUE"
"5404-53_3"	"SL004871"	"DR6"	"Tumor necrosis factor receptor superfamily member 21"	"6"	"47231532"	"47309905"	"TNFRSF21"	"27242"	"O75509"	"Apoptosis"	""	""	"PPARA activates gene expression"	"Peripheral T-cell Tolerance Overview"	""	""	"Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation."	""	"TRUE"
"5410-53_3"	"SL007295"	"CAD15"	"Cadherin-15"	"16"	"89171767"	"89195492"	"CDH15"	"1013"	"P55291"	""	""	""	"Adherens junctions interactions|CDO in myogenesis"	""	""	""	"Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation."	""	"TRUE"
"5412-53_3"	"SL004134"	"CD27"	"CD27 antigen"	"12"	"6444867"	"6451718"	"CD27"	"939"	"P26842"	""	""	""	""	""	""	"unspecified application"	"Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1."	"31|43"	"TRUE"
"5424-55_3"	"SL003690"	"RANK"	"Tumor necrosis factor receptor superfamily member 11A"	"18"	"62325287"	"62391292"	"TNFRSF11A"	"8792"	"Q9Y6Q6"	"Osteoclast Signaling|RANKL/RANK Signaling Pathway"	""	""	""	""	""	""	"Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells."	""	"TRUE"
"5440-26_3"	"SL004594"	"Troponin I, skeletal, fast twitch"	"Troponin I, fast skeletal muscle"	"11"	"1838989"	"1841680"	"TNNI2"	"7136"	"P48788"	"Striated Muscle Contraction"	""	""	"Striated Muscle Contraction"	""	""	"unspecified application"	"Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity."	""	"TRUE"
"5441-67_3"	"SL001761"	"Troponin I"	"Troponin I, cardiac muscle"	"19"	"55151767"	"55157773"	"TNNI3"	"7137"	"P19429"	"Striated Muscle Contraction"	""	""	"Striated Muscle Contraction"	""	""	"diagnosis|efficacy|safety|unspecified application"	"Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity."	""	"TRUE"
"5443-62_2"	"SL002505"	"ANP"	"Atrial natriuretic factor"	"1"	"11845709"	"11848345"	"NPPA"	"4878"	"P01160"	"MicroRNAs in cardiomyocyte hypertrophy"	"AP-1 transcription factor network"	""	"Amyloids|YAP1- and WWTR1 (TAZ)-stimulated gene expression"	""	""	"diagnosis|efficacy|prognosis|unspecified application"	"Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3."	""	"TRUE"
"5451-1_3"	"SL003166"	"ALCAM"	"CD166 antigen"	"3"	"105366909"	"105576900"	"ALCAM"	"214"	"Q13740"	""	""	""	"L1CAM interactions"	""	""	"prognosis"	"Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts (PubMed:7760007, PubMed:15496415, PubMed:15048703, PubMed:16352806, PubMed:23169771, PubMed:24945728). Promotes T-cell activation and proliferation via its interactions with CD6 (PubMed:15048703, PubMed:16352806, PubMed:24945728). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (PubMed:15294938, PubMed:16352806). Mediates homotypic interactions with cells that express ALCAM (PubMed:15496415, PubMed:16352806). Required for normal hematopoietic stem cell engraftment in the bone marrow (PubMed:24740813). Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction (PubMed:23169771). Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions (PubMed:15496415, PubMed:23169771). Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity)."	""	"TRUE"
"5459-33_3"	"SL010456"	"CYTN"	"Cystatin-SN"	"20"	"23747553"	"23751268"	"CST1"	"1469"	"P01037"	""	""	""	""	""	""	""	"Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well."	"110|211|248"	"TRUE"
"5468-67_3"	"SL011068"	"IL-17 RC"	"Interleukin-17 receptor C"	"3"	"9917074"	"9933630"	"IL17RC"	"84818"	"Q8NAC3"	""	""	""	""	""	""	""	"Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA (PubMed:16785495). Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA (PubMed:18684971). Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA (PubMed:17911633). Activation of IL17RC leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1 (PubMed:16785495)."	""	"TRUE"
"5475-10_3"	"SL000553"	"PKC-B-II"	"Protein kinase C beta type (splice variant beta-II)"	"16"	"23836001"	"24220611"	"PRKCB"	"5579"	"P05771"	"B Cell Receptor Signaling Pathway|Calcium Regulation in the Cardiac Cell|EGF/EGFR Signaling Pathway|G Protein Signaling Pathways|Insulin Signaling|Kit receptor signaling pathway|MAPK signaling pathway|MicroRNAs in cardiomyocyte hypertrophy|Myometrial Relaxation and Contraction Pathways|Physiological and Pathological Hypertrophy  of the Heart|Wnt Signaling Pathway|Wnt Signaling Pathway and Pluripotency|miRs in Muscle Cell Differentiation"	"Downstream signaling in naïve CD8+ T cells|Endothelins|Fc-epsilon receptor I signaling in mast cells|IL2-mediated signaling events|IL8- and CXCR1-mediated signaling events|IL8- and CXCR2-mediated signaling events|JNK signaling in the CD4+ TCR pathway|PAR1-mediated thrombin signaling events|Ras signaling in the CD4+ TCR pathway|Regulation of Ras family activation|Role of Calcineurin-dependent NFAT signaling in lymphocytes|Signaling events mediated by VEGFR1 and VEGFR2|TCR signaling in naïve CD4+ T cells|TCR signaling in naïve CD8+ T cells|Thromboxane A2 receptor signaling|VEGFR1 specific signals"	""	"Activation of NF-kappaB in B cells|Depolymerisation of the Nuclear Lamina|Disinhibition of SNARE formation|G alpha (z) signalling events|Response to elevated platelet cytosolic Ca2+|Trafficking of GluR2-containing AMPA receptors|VEGFR2 mediated cell proliferation|WNT5A-dependent internalization of FZD4"	"T-cell-Dependent B-cell Activation|T-cell-Independent B-cell Activation"	"enzastaurin|ruboxistaurin|ingenol mebutate"	"diagnosis|efficacy|unspecified application"	"Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. May participate in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription."	""	"FALSE"
"5476-66_3"	"SL000556"	"PKC-G"	"Protein kinase C gamma type"	"19"	"53879190"	"53907652"	"PRKCG"	"5582"	"P05129"	"Calcium Regulation in the Cardiac Cell|G Protein Signaling Pathways|MAPK signaling pathway|Myometrial Relaxation and Contraction Pathways|Wnt Signaling Pathway|miRs in Muscle Cell Differentiation"	"Endothelins|IL8- and CXCR1-mediated signaling events|IL8- and CXCR2-mediated signaling events|PAR1-mediated thrombin signaling events|Retinoic acid receptors-mediated signaling|Role of Calcineurin-dependent NFAT signaling in lymphocytes|Thromboxane A2 receptor signaling"	""	"Calmodulin induced events|Disinhibition of SNARE formation|G alpha (z) signalling events|Response to elevated platelet cytosolic Ca2+|Trafficking of GluR2-containing AMPA receptors|WNT5A-dependent internalization of FZD4"	""	"ingenol mebutate"	""	"Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress (By similarity). Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. Stabilizes the core clock component ARNTL/BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock (By similarity)."	""	"TRUE"
"5487-7_3"	"SL016928"	"SLAF7"	"SLAM family member 7"	"1"	"160739057"	"160754821"	"SLAMF7"	"57823"	"Q9NQ25"	""	""	""	""	"Natural Killer Cell Activation through ITSM-Containing Receptors"	""	""	"Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528)."	"63|176"	"TRUE"
"5488-74_3"	"SL010516"	"SRCN1"	"Proto-oncogene tyrosine-protein kinase Src"	"20"	"37344685"	"37406050"	"SRC"	"6714"	"P12931"	"Alpha 6 Beta 4 signaling pathway|Androgen receptor signaling pathway|Angiogenesis|EPO Receptor Signaling|ErbB signaling pathway|FSH signaling pathway|Focal Adhesion|IL-3 Signaling Pathway|Integrin-mediated cell adhesion|Kit receptor signaling pathway|Leptin signaling pathway|Notch Signaling Pathway|Prolactin Signaling Pathway|RANKL/RANK Signaling Pathway|Senescence and Autophagy|Signaling of Hepatocyte Growth Factor Receptor|TGF beta Signaling Pathway|TSH signaling pathway|angiogenesis overview"	"Alpha-synuclein signaling|Alpha4 beta1 integrin signaling events|Alpha9 beta1 integrin signaling events|Arf6 signaling events|Atypical NF-kappaB pathway|CDC42 signaling events|CXCR3-mediated signaling events|CXCR4-mediated signaling events|Class I PI3K signaling events|Class I PI3K signaling events mediated by Akt|E-cadherin signaling in keratinocytes|E-cadherin signaling in the nascent adherens junction|EGF receptor (ErbB1) signaling pathway|EPHA forward signaling|EPHA2 forward signaling|EPHB forward signaling|Endothelins|Ephrin B reverse signaling|ErbB1 downstream signaling|ErbB2/ErbB3 signaling events|FAS (CD95) signaling pathway|FGF signaling pathway|Glypican 1 network|Integrins in angiogenesis|Internalization of ErbB1|LPA receptor mediated events|Nectin adhesion pathway|Netrin-mediated signaling events|Nongenotropic Androgen signaling|PDGFR-beta signaling pathway|Plasma membrane estrogen receptor signaling|Posttranslational regulation of adherens junction stability and dissassembly|Regulation of Androgen receptor activity|Regulation of p38-alpha and p38-beta|S1P3 pathway|Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)|Signaling events mediated by PRL|Signaling events mediated by PTP1B|Signaling events mediated by TCPTP|Signaling events mediated by VEGFR1 and VEGFR2|Signaling events mediated by focal adhesion kinase|Signaling events regulated by Ret tyrosine kinase|Syndecan-2-mediated signaling events|Syndecan-3-mediated signaling events|Thromboxane A2 receptor signaling|Trk receptor signaling mediated by PI3K and PLC-gamma|Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling|amb2 Integrin signaling"	""	"ADP signalling through P2Y purinoceptor 1|CD28 co-stimulation|CLEC7A (Dectin-1) signaling|CTLA4 inhibitory signaling|DCC mediated attractive signaling|Downstream signal transduction|EPH-Ephrin signaling|EPH-ephrin mediated repulsion of cells|EPHA-mediated growth cone collapse|EPHB-mediated forward signaling|Ephrin signaling|FCGR activation|GAB1 signalosome|GP1b-IX-V activation signalling|GRB2:SOS provides linkage to MAPK signaling for Integrins|Integrin alphaIIb beta3 signaling|NCAM signaling for neurite out-growth|Netrin mediated repulsion signals|PECAM1 interactions|RHO GTPases Activate Formins|Recycling pathway of L1|Regulation of KIT signaling|Signal regulatory protein (SIRP) family interactions|Signaling by EGFR|Signaling by ERBB2|Signaling by SCF-KIT|Spry regulation of FGF signaling|Thrombin signalling through proteinase activated receptors (PARs)|VEGFA-VEGFR2 Pathway|VEGFR2 mediated cell proliferation|c-src mediated regulation of Cx43 function and closure of gap junctions|p130Cas linkage to MAPK signaling for integrins|p38MAPK events"	"ADRA2C/ADRB2 -> synaptic endocytosis|ADRA2C/ADRB2 -> vasoconstriction|ADRB1 -> prostaglandin generation|AdenosineR -> NF-kB signaling|Adherens Junction Assembly (Cadherins)|Adherens Junction Assembly (Nectin)|AdrenergicRb -> CREB signaling|AdrenergicRb -> STAT3 signaling|AngiopoietinR -> AP-1 signaling|CHRM1 -> IL2 production|CSF1R -> STAT signaling|CholinergicRm -> CREB/ELK-SRF signaling|DRD2 -> TRPC1 transcription|DRD2/4 -> membrane transport|DopamineR2 -> AP-1/CREB/ELK-SRF signaling|DopamineR2 -> NF-kB signaling|EGFR -> AP-1/ATF2 signaling|EGFR -> AP-1/CREB/ELK-SRF/MYC signaling|EGFR -> CTNND signaling|EGFR -> NCOR2 signaling|EGFR/ERBB -> STAT signaling|EGFR/ERBB2 -> CTNNB signaling|EGFR/ERBB2 -> HIF1A signaling|EGFR/ERBB2 -> TP53 signaling|EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG signaling|EPHB -> NMDA receptor activation|ErythropoietinR -> AP-1/CREB/MYC signaling|FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling|FGFR1 -> STAT signaling|FibronectinR -> AP-1/ELK-SRF/SREBF signaling|Focal Junction Assembly|GABA(B)R -> postsynaptic inhibition|GDNF -> HSF1 signaling|GFs/TNF -> ion channels|GRM1/5 -> CREB signaling|HGFR -> AP-1/CREB/MYC signaling|HGFR -> STAT signaling|IGF1R -> ELK-SRF/HIF1A/MYC/SREBF signaling|IGF1R -> MEF/MYOD/MYOG signaling|IL6ST -> STAT5B signaling|KIT -> MITF signaling|MacrophageR -> CEBPB/NF-kB signaling|NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling|NTRK -> FOXO/MYCN signaling|NTRK1/2/3 -> acetylcholine production|Nociception-related DRD2 expression targets|Nociception-related IL6 expression targets|OPRK -> pain perception|OpioidR -> CREB/ELK-SRF/STAT3 signaling|PDGFR -> AP-1/MYC signaling|PDGFR -> STAT signaling|PECAM -> STAT signaling|Regulation of calcium flux|Regulation of potassium flux|Summarized nociception-related expression targets|Summarized vascular motility pathway|T-cell receptor -> ATF/CREB signaling|TNFRSF5/13B -> NFATC1 signaling|ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling|ThrombinR -> NF-kB signaling|ThrombinR -> STAT1 signaling|ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling|VEGFR -> AP-1/CREB/MYC signaling|VEGFR -> ATF/CREB/ELK-SRF signaling|VEGFR -> CTNNB signaling|VEGFR -> CTNND signaling|VEGFR -> NFATC signaling|VEGFR -> STAT signaling|VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling|VasopressinR1 -> MEF/MYOD/NFATC/MYOG signaling|VasopressinR1 -> STAT signaling|VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling|VasopressinR2 -> MEF/MYOD/NFATC/MYOG signaling|VasopressinR2 -> STAT signaling"	"dasatinib|AZM-475271|saracatinib|nintedanib|bosutinib"	"diagnosis|disease progression|efficacy|prognosis|response to therapy"	"Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1. Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors. Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1. Plays a role in EGF-mediated calcium-activated chloride channel activation. Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of ADRBK1, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor. Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus. Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase. Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation. Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731'. Enhances DDX58/RIG-I-elicited antiviral signaling. Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376'. Phosphorylates BCAR1 at 'Tyr-128'. Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity. Required for podosome formation (By similarity)."	""	"TRUE"
"5489-18_3"	"SL010250"	"Stress-induced-phosphoprotein 1"	"Stress-induced-phosphoprotein 1"	"11"	"64185272"	"64204543"	"STIP1"	"10963"	"P31948"	""	""	""	""	""	""	""	"Mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB)."	""	"TRUE"
"5490-53_3"	"SL010384"	"Testican-1"	"Testican-1"	"5"	"136975298"	"137598379"	"SPOCK1"	"6695"	"Q08629"	"Adipogenesis"	""	""	""	""	""	""	"May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous system."	""	"TRUE"
"5491-12_3"	"SL010471"	"Testican-2"	"Testican-2"	"10"	"72059035"	"72089032"	"SPOCK2"	"9806"	"Q92563"	""	""	""	""	""	""	"diagnosis"	"May participate in diverse steps of neurogenesis. Binds calcium."	""	"TRUE"
"5494-52_3"	"SL009790"	"RUXF"	"Small nuclear ribonucleoprotein F"	"12"	"95858928"	"95903828"	"SNRPF"	"6636"	"P62306"	"mRNA processing"	""	""	"Cleavage of Growing Transcript in the Termination Region|SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs|SLBP independent Processing of Histone Pre-mRNAs|mRNA Splicing - Major Pathway|mRNA Splicing - Minor Pathway|snRNP Assembly"	""	""	""	"Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3'-end processing."	"306"	"TRUE"
"10000-28_3"	""	"CRBB2"	"Beta-crystallin B2"	"22"	"25615489"	"25627836"	"CRYBB2"	"ENSG00000244752"	"P43320"	""	""	""	""	""	""	""	"Crystallins are the dominant structural components of the vertebrate eye lens."	""	"FALSE"
"10006-25_3"	""	"ELK1"	"ETS domain-containing protein Elk-1"	"X"	"47494920"	"47510003"	"ELK1"	"ENSG00000126767"	"P19419"	""	""	""	""	""	""	""	"Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK-signaling pathway stimulation (By similarity)."	""	"FALSE"
"10008-43_3"	""	"GUC1A"	"Guanylyl cyclase-activating protein 1"	"6"	"42123144"	"42147794"	"GUCA1A"	"ENSG00000048545"	"P43080"	""	""	""	""	""	""	""	"Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated (PubMed:19459154). This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure."	""	"FALSE"
"10011-65_3"	""	"OCRL"	"Inositol polyphosphate 5-phosphatase OCRL-1"	"X"	"128673826"	"128726538"	"OCRL"	"ENSG00000122126"	"Q01968"	""	""	""	""	""	""	""	"Converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Also converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate (PubMed:25869668, PubMed:7761412, PubMed:9430698). May function in lysosomal membrane trafficking by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with lysosomes. Involved in primary cilia assembly (PubMed:22228094, PubMed:22543976)."	""	"FALSE"
"10015-119_3"	""	"KCAB2"	"Voltage-gated potassium channel subunit beta-2"	"1"	"6051526"	"6161253"	"KCNAB2"	"ENSG00000069424"	"Q13303"	""	""	""	""	""	""	""	"Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7649300, PubMed:11825900). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:7649300, PubMed:11825900). Promotes KCNA4 channel closure (PubMed:7649300, PubMed:11825900). Modulates the functional properties of KCNA5 (By similarity). Enhances KCNB2 channel activity (By similarity). Binds NADPH and has NADPH-dependent aldoketoreductase activity (By similarity). Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) (By similarity)."	""	"FALSE"
"10021-1_3"	""	"SUSD2"	"Sushi domain-containing protein 2"	"22"	"24577227"	"24585078"	"SUSD2"	"ENSG00000099994"	"Q9UGT4"	""	""	""	""	""	""	""	"May be a cytokine receptor for C10ORF99. May be a tumor suppressor; together with C10ORF99 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403). May play a role in breast tumorigenesis (PubMed:23131994)."	""	"FALSE"
"10034-16_3"	""	"FRK"	"Tyrosine-protein kinase FRK"	"6"	"116252312"	"116381921"	"FRK"	"ENSG00000111816"	"P42685"	""	""	""	""	""	""	""	"Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor."	""	"FALSE"
"10035-6_3"	""	"DUS4"	"Dual specificity protein phosphatase 4"	"8"	"29190581"	"29208185"	"DUSP4"	"ENSG00000120875"	"Q13115"	""	""	""	""	""	""	""	"Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2."	""	"FALSE"
"10036-201_3"	""	"ZHX3"	"Zinc fingers and homeoboxes protein 3"	"20"	"39807088"	"39946312"	"ZHX3"	"ENSG00000174306"	"Q9H4I2"	""	""	""	""	""	""	""	"Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA."	""	"FALSE"
"10037-98_3"	""	"SIG12"	"Sialic acid-binding Ig-like lectin 12"	"19"	"51994611"	"52005043"	"SIGLEC12"	"ENSG00000254521"	"Q96PQ1"	""	""	""	""	""	""	""	"Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface."	""	"FALSE"
"10039-32_3"	""	"PNP"	"Purine nucleoside phosphorylase"	"14"	"20937113"	"20945253"	"PNP"	"ENSG00000198805"	"P00491"	""	""	""	""	""	""	""	"The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate."	""	"FALSE"
"10041-3_3"	""	"HNF4A"	"Hepatocyte nuclear factor 4-alpha"	"20"	"42984340"	"43063236"	"HNF4A"	"ENSG00000101076"	"P41235"	""	""	""	""	""	""	""	"Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1-antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1-alpha. May be essential for development of the liver, kidney and intestine."	""	"FALSE"
"10047-12_3"	""	"NCF-2"	"Neutrophil cytosol factor 2"	"1"	"183524698"	"183560011"	"NCF2"	"ENSG00000116701"	"P19878"	""	""	""	""	""	""	""	"NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production)."	""	"FALSE"
"10048-7_3"	""	"PEBB"	"Core-binding factor subunit beta"	"16"	"67063019"	"67134961"	"CBFB"	"ENSG00000067955"	"Q13951"	""	""	""	""	""	""	""	"Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation."	""	"FALSE"
"10075-75_3"	""	"ACBD6"	"Acyl-CoA-binding domain-containing protein 6"	"1"	"180238788"	"180472089"	"ACBD6"	"ENSG00000230124"	"Q9BR61"	""	""	""	""	""	""	""	"Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids."	""	"FALSE"
"10076-1_3"	""	"AP4M1"	"AP-4 complex subunit mu-1"	"7"	"99699172"	"99707968"	"AP4M1"	"ENSG00000221838"	"O00189"	""	""	""	""	""	""	""	"Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10436028, PubMed:11139587, PubMed:10066790, PubMed:11802162, PubMed:20230749). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system (PubMed:11139587, PubMed:20230749). It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons (By similarity). Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos (PubMed:10436028, PubMed:11139587, PubMed:26544806, PubMed:20230749). The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal (By similarity)."	""	"FALSE"
"10080-9_3"	""	"EI2BA"	"Translation initiation factor eIF-2B subunit alpha"	"12"	"124104953"	"124118313"	"EIF2B1"	"ENSG00000111361"	"Q14232"	""	""	""	""	""	""	""	"Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP."	""	"FALSE"
"10085-25_3"	""	"STAR"	"Steroidogenic acute regulatory protein, mitochondrial"	"8"	"38001167"	"38008783"	"STAR"	"ENSG00000147465"	"P49675"	""	""	""	""	""	""	""	"Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone."	""	"FALSE"
"10089-7_3"	""	"ASML"	"N-acetylserotonin O-methyltransferase-like protein"	"X"	"1522032"	"1572655"	"ASMTL"	"ENSG00000169093"	"O95671"	""	""	""	""	""	""	""	"Unknown. The presence of the putative catalytic domain of S-adenosyl-L-methionine binding argues for a methyltransferase activity."	""	"FALSE"
"10346-5_3"	""	"STAT3"	"Signal transducer and activator of transcription 3"	"17"	"40465342"	"40540586"	"STAT3"	"ENSG00000168610"	"P40763"	""	""	""	""	""	""	""	"Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:17344214, PubMed:18242580, PubMed:23084476). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (PubMed:28065600). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity)."	""	"FALSE"
"10361-25_3"	""	"OAS1"	"2'-5'-oligoadenylate synthase 1"	"12"	"113344582"	"113371027"	"OAS1"	"ENSG00000089127"	"P00973"	""	""	""	""	""	""	""	"Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L."	""	"FALSE"
"10364-6_3"	""	"SMAD2"	"Mothers against decapentaplegic homolog 2"	"18"	"45335328"	"45457517"	"SMAD2"	"ENSG00000175387"	"Q15796"	""	""	""	""	""	""	""	"Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator."	""	"FALSE"
"10365-132_3"	""	"IL-23"	"Interleukin-23"	"5|12"	"158741791|56727958"	"158757895|56734194"	"IL12B|IL23A"	"ENSG00000113302|ENSG00000110944"	"P29460|Q9NPF7"	""	""	""	""	""	""	""	"Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.|Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis."	""	"FALSE"
"10366-11_3"	""	"PDGFRA"	"Platelet-derived growth factor receptor alpha"	"4"	"55095264"	"55164414"	"PDGFRA"	"ENSG00000134853"	"P16234"	""	""	""	""	""	""	""	"Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor."	""	"FALSE"
"10370-21_3"	""	"STAT1"	"Signal transducer and activator of transcription 1-alpha/beta"	"2"	"191829084"	"191885686"	"STAT1"	"ENSG00000115415"	"P42224"	""	""	""	""	""	""	""	"Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus (PubMed:28753426). ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated (PubMed:26479788). It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4."	""	"FALSE"
"10372-18_3"	""	"STAT6"	"Signal transducer and activator of transcription 6"	"12"	"57489191"	"57525922"	"STAT6"	"ENSG00000166888"	"P42226"	""	""	""	""	""	""	""	"Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling."	""	"FALSE"
"10416-79_3"	""	"MT1F"	"Metallothionein-1F"	"16"	"56691606"	"56694610"	"MT1F"	"ENSG00000198417"	"P04733"	""	""	""	""	""	""	""	"Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids."	""	"FALSE"
"10419-1_3"	""	"SCAR5"	"Scavenger receptor class A member 5"	"8"	"27727399"	"27850244"	"SCARA5"	"ENSG00000168079"	"Q6ZMJ2"	""	""	""	""	""	""	""	"Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1)."	""	"FALSE"
"10427-2_3"	""	"KCNE2"	"Potassium voltage-gated channel subfamily E member 2"	"21"	"35736323"	"35743688"	"KCNE2"	"ENSG00000159197"	"Q9Y6J6"	""	""	""	""	""	""	""	"Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with HCN1 and HCN2 and increase potassium current. Interacts with KCNQ1; forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (PubMed:11101505)."	""	"FALSE"
"10428-1_3"	""	"KI2S2"	"Killer cell immunoglobulin-like receptor 2DS2"	"19"	"131449"	"145745"	"KIR2DS2"	"ENSG00000278300"	"P43631"	""	""	""	""	""	""	""	"Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells."	""	"FALSE"
"10440-26_3"	""	"ACAM"	"CXADR-like membrane protein"	"11"	"122940573"	"123065989"	"CLMP"	"ENSG00000166250"	"Q9H6B4"	""	""	""	""	""	""	""	"May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development."	""	"FALSE"
"10442-1_3"	""	"TM190"	"Transmembrane protein 190"	"19"	"55888204"	"55889612"	"TMEM190"	"ENSG00000160472"	"Q8WZ59"	""	""	""	""	""	""	""	"EBI-10278423"	""	"FALSE"
"10445-20_3"	""	"ApoM"	"Apolipoprotein M"	"6"	"31620193"	"31625987"	"APOM"	"ENSG00000204444"	"O95445"	""	""	""	""	""	""	""	"Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid."	""	"FALSE"
"10447-18_3"	""	"PABP3"	"Polyadenylate-binding protein 3"	"13"	"25670006"	"25673392"	"PABPC3"	"ENSG00000151846"	"Q9H361"	""	""	""	""	""	""	""	"Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Binds poly(A) with a slightly lower affinity as compared to PABPC1."	""	"FALSE"
"10455-196_3"	""	"IL-31"	"Interleukin-31"	"12"	"122656577"	"122658746"	"IL31"	"ENSG00000204671"	"Q6EBC2"	""	""	""	""	""	""	""	"Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR (PubMed:15184896). May function in skin immunity (PubMed:15184896). Enhances myeloid progenitor cell survival in vitro (By similarity). Induces RETNLA and serum amyloid A protein expression in macrophages (By similarity)."	""	"FALSE"
"10463-23_3"	""	"Alkaline phosphatase, intestine"	"Intestinal-type alkaline phosphatase"	"2"	"233320833"	"233324742"	"ALPI"	"ENSG00000163295"	"P09923"	""	""	""	""	""	""	""	"A phosphate monoester + H(2)O = an alcohol + phosphate."	""	"FALSE"
"10467-58_3"	""	"CTXN3"	"Cortexin-3"	"5"	"126984736"	"126994322"	"CTXN3"	"ENSG00000205279"	"Q4LDR2"	""	""	""	""	""	""	""	"EBI-12019274"	""	"FALSE"
"10476-23_3"	""	"MCFD2"	"Multiple coagulation factor deficiency protein 2"	"2"	"47129009"	"47168994"	"MCFD2"	"ENSG00000180398"	"Q8NI22"	""	""	""	""	""	""	""	"The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Plays a role in the secretion of coagulation factors."	""	"FALSE"
"10490-3_3"	""	"RPN1"	"Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1"	"3"	"128338813"	"128399918"	"RPN1"	"ENSG00000163902"	"P04843"	""	""	""	""	""	""	""	"Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains."	""	"FALSE"
"10491-21_3"	""	"MPRD"	"Cation-dependent mannose-6-phosphate receptor"	"12"	"9092959"	"9102551"	"M6PR"	"ENSG00000003056"	"P20645"	""	""	""	""	""	""	""	"Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex."	""	"FALSE"
"10497-242_3"	""	"COX8A"	"Cytochrome c oxidase subunit 8A, mitochondrial"	"11"	"63742079"	"63744015"	"COX8A"	"ENSG00000176340"	"P10176"	""	""	""	""	""	""	""	"This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport."	""	"FALSE"
"10502-15_3"	""	"PRPC"	"Salivary acidic proline-rich phosphoprotein 1/2"	"12"	"11081835"	"11084940"	"PRH2"	"ENSG00000134551"	"P02810"	""	""	""	""	""	""	""	"PRP's act as highly potent inhibitors of crystal growth of calcium phosphates. They provide a protective and reparative environment for dental enamel which is important for the integrity of the teeth."	""	"FALSE"
"10512-13_3"	""	"IL3RB"	"Cytokine receptor common subunit beta"	"22"	"37309670"	"37336491"	"CSF2RB"	"ENSG00000100368"	"P32927"	""	""	""	""	""	""	""	"High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor."	""	"FALSE"
"10514-5_3"	""	"PGD2 synthase"	"Prostaglandin-H2 D-isomerase"	"9"	"139871957"	"139879887"	"PTGDS"	"ENSG00000107317"	"P41222"	""	""	""	""	""	""	""	"Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system."	""	"FALSE"
"10522-167_3"	""	"PCDB4"	"Protocadherin beta-4"	"5"	"140501381"	"140505205"	"PCDHB4"	"ENSG00000081818"	"Q9Y5E5"	""	""	""	""	""	""	""	"Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain."	""	"FALSE"
"10557-6_3"	""	"TEX29"	"Testis-expressed sequence 29 protein"	"13"	"111968531"	"111996596"	"TEX29"	"ENSG00000153495"	"Q8N6K0"	""	""	""	""	""	""	""	"Membrane"	""	"FALSE"
"10565-19_3"	""	"SLIK3"	"SLIT and NTRK-like protein 3"	"3"	"164904508"	"164914897"	"SLITRK3"	"ENSG00000121871"	"O94933"	""	""	""	""	""	""	""	"Suppresses neurite outgrowth."	""	"FALSE"
"10572-65_3"	""	"CST8"	"Cystatin-8"	"20"	"23471738"	"23476655"	"CST8"	"ENSG00000125815"	"O60676"	""	""	""	""	""	""	""	"Performs a specialized role during sperm development and maturation."	""	"FALSE"
"10575-31_3"	""	"PUF60"	"Poly(U)-binding-splicing factor PUF60"	"8"	"144898514"	"144912029"	"PUF60"	"ENSG00000179950"	"Q9UHX1"	""	""	""	""	""	""	""	"DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with TROVE2. Binds to poly(U) RNA."	""	"FALSE"
"10584-7_3"	""	"NDUS4"	"NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial"	"5"	"52856463"	"52979170"	"NDUFS4"	"ENSG00000164258"	"O43181"	""	""	""	""	""	""	""	"Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone."	""	"FALSE"
"10605-22_3"	""	"APMAP"	"Adipocyte plasma membrane-associated protein"	"20"	"24943561"	"24973615"	"APMAP"	"ENSG00000101474"	"Q9HDC9"	""	""	""	""	""	""	""	"Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation."	""	"FALSE"
"10608-9_3"	""	"HIS1"	"Histatin-1"	"4"	"70916119"	"70924562"	"HTN1"	"ENSG00000126550"	"P15515"	""	""	""	""	""	""	""	"Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities."	""	"FALSE"
"10615-18_3"	""	"MYP0"	"Myelin protein P0"	"1"	"161274525"	"161279762"	"MPZ"	"ENSG00000158887"	"P25189"	""	""	""	""	""	""	""	"Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction."	""	"FALSE"
"10620-21_3"	""	"PSP-94"	"Beta-microseminoprotein"	"10"	"51549552"	"51562514"	"MSMB"	"ENSG00000263639"	"P08118"	""	""	""	""	""	""	""	"Homodimer; Interacts with PI16."	""	"FALSE"
"10626-116_3"	""	"SIA7C"	"Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3"	"1"	"76540404"	"77100286"	"ST6GALNAC3"	"ENSG00000184005"	"Q8NDV1"	""	""	""	""	""	""	""	"Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. ST6GalNAcIII prefers glycolipids to glycoproteins (By similarity)."	""	"FALSE"
"10627-87_3"	""	"APLP2"	"Amyloid-like protein 2"	"11"	"129939732"	"130014706"	"APLP2"	"ENSG00000084234"	"Q06481"	""	""	""	""	""	""	""	"May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity)."	""	"FALSE"
"10630-5_3"	""	"HTAI2"	"Oxidoreductase HTATIP2"	"11"	"20385231"	"20405329"	"HTATIP2"	"ENSG00000109854"	"Q9BUP3"	""	""	""	""	""	""	""	"Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect."	""	"FALSE"
"10631-9_3"	""	"PGRC2"	"Membrane-associated progesterone receptor component 2"	"4"	"129190392"	"129209984"	"PGRMC2"	"ENSG00000164040"	"O15173"	""	""	""	""	""	""	""	"Receptor for steroids."	""	"FALSE"
"10639-1_3"	""	"2DMA"	"HLA class II histocompatibility antigen, DM alpha chain"	"6"	"32916390"	"32936871"	"HLA-DMA"	"ENSG00000204257"	"P28067"	""	""	""	""	""	""	""	"Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO."	""	"FALSE"
"10647-18_3"	""	"ASCC1"	"Activating signal cointegrator 1 complex subunit 1"	"10"	"73855790"	"73976892"	"ASCC1"	"ENSG00000138303"	"Q8N9N2"	""	""	""	""	""	""	""	"Enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction."	""	"FALSE"
"10658-28_3"	""	"SC11C"	"Signal peptidase complex catalytic subunit SEC11C"	"18"	"56806709"	"56826068"	"SEC11C"	"ENSG00000166562"	"Q9BY50"	""	""	""	""	""	""	""	"Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum."	""	"FALSE"
"10677-9_3"	""	"NDUB4"	"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4"	"3"	"120315156"	"120321347"	"NDUFB4"	"ENSG00000065518"	"O95168"	""	""	""	""	""	""	""	"Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone."	""	"FALSE"
"10692-48_3"	""	"CR026"	"Dynactin-associated protein"	"18"	"52254988"	"52266724"	"DYNAP"	"ENSG00000178690"	"Q8N1N2"	""	""	""	""	""	""	""	"Plays a role in the regulation of cell proliferation. Promotes activation of the AKT1 signaling pathway. Promotes phosphorylation of AKT1 at 'Ser-473'."	""	"FALSE"
"10699-52_3"	""	"LRP1"	"Prolow-density lipoprotein receptor-related protein 1"	"12"	"57522276"	"57607134"	"LRP1"	"ENSG00000123384"	"Q07954"	""	""	""	""	""	""	""	"Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed:11907044, PubMed:12888553, PubMed:12713657). Acts as an alpha-2-macroglobulin receptor (PubMed:26142438)."	""	"FALSE"
"10701-30_3"	""	"Cadherin-12"	"Cadherin-12"	"5"	"21750782"	"22853731"	"CDH12"	"ENSG00000154162"	"P55289"	""	""	""	""	""	""	""	"Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types."	""	"FALSE"
"10708-3_3"	""	"GON2"	"Progonadoliberin-2"	"20"	"3024268"	"3026393"	"GNRH2"	"ENSG00000125787"	"O43555"	""	""	""	""	""	""	""	"Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones."	""	"FALSE"
"10716-35_3"	""	"PSMD5"	"26S proteasome non-ATPase regulatory subunit 5"	"9"	"123577774"	"123605262"	"PSMD5"	"ENSG00000095261"	"Q16401"	""	""	""	""	""	""	""	"Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5."	""	"FALSE"
"10723-41_3"	""	"WDR1"	"WD repeat-containing protein 1"	"4"	"10075963"	"10118573"	"WDR1"	"ENSG00000071127"	"O75083"	""	""	""	""	""	""	""	"Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458). Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565)."	""	"FALSE"
"10748-216_3"	""	"PCDB2"	"Protocadherin beta-2"	"5"	"140474163"	"140478287"	"PCDHB2"	"ENSG00000112852"	"Q9Y5E7"	""	""	""	""	""	""	""	"Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain."	""	"FALSE"
"10760-107_3"	""	"GRIA4"	"Glutamate receptor 4"	"11"	"105480721"	"105852819"	"GRIA4"	"ENSG00000152578"	"P48058"	""	""	""	""	""	""	""	"Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate."	""	"FALSE"
"10772-21_3"	""	"CGAT2"	"Chondroitin sulfate N-acetylgalactosaminyltransferase 2"	"10"	"43633934"	"43680756"	"CSGALNACT2"	"ENSG00000169826"	"Q8N6G5"	""	""	""	""	""	""	""	"Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains."	""	"FALSE"
"10832-24_3"	""	"B4GT6"	"Beta-1,4-galactosyltransferase 6"	"18"	"29202210"	"29265799"	"B4GALT6"	"ENSG00000118276"	"Q9UBX8"	""	""	""	""	""	""	""	"Required for the biosynthesis of glycosphingolipids."	""	"FALSE"
"10852-114_3"	""	"HNRDL"	"Heterogeneous nuclear ribonucleoprotein D-like"	"4"	"83343717"	"83351561"	"HNRPDL"	"ENSG00000152795"	"O14979"	""	""	""	""	""	""	""	"Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes (By similarity). Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter (By similarity). Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence."	""	"FALSE"
"10854-15_3"	""	"GCNT4"	"Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4"	"5"	"74321171"	"74326724"	"GCNT4"	"ENSG00000176928"	"Q9P109"	""	""	""	""	""	""	""	"Glycosyltransferase that mediates core 2 O-glycan branching, an important step in mucin-type biosynthesis. Does not have core 4 O-glycan or I-branching enzyme activity."	""	"FALSE"
"10885-36_3"	""	"CF089"	"Bombesin receptor-activated protein C6orf89"	"6"	"36839646"	"36896740"	"C6orf89"	"ENSG00000198663"	"Q6UWU4"	""	""	""	""	""	""	""	"Exhibits histone deacetylase (HDAC) enhancer properties (PubMed:23460338). May play a role in cell cycle progression and wound repair of bronchial epithelial cells (PubMed:21857995)."	""	"FALSE"
"10892-8_3"	""	"OSMR"	"Oncostatin-M-specific receptor subunit beta"	"5"	"38845960"	"38945698"	"OSMR"	"ENSG00000145623"	"Q99650"	""	""	""	""	""	""	""	"Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events."	""	"FALSE"
"10900-272_3"	""	"STMN2"	"Stathmin-2"	"8"	"80523049"	"80578410"	"STMN2"	"ENSG00000104435"	"Q93045"	""	""	""	""	""	""	""	"Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity)."	""	"FALSE"
"10903-50_3"	""	"STX8"	"Syntaxin-8"	"17"	"9153788"	"9479908"	"STX8"	"ENSG00000170310"	"Q9UNK0"	""	""	""	""	""	""	""	"Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER."	""	"FALSE"
"10914-4_3"	""	"CHIC2"	"Cysteine-rich hydrophobic domain-containing protein 2"	"4"	"54875956"	"54930857"	"CHIC2"	"ENSG00000109220"	"Q9UKJ5"	""	""	""	""	""	""	""	"EBI-741528"	""	"FALSE"
"10916-44_3"	""	"PLA2R"	"Secretory phospholipase A2 receptor"	"2"	"160788517"	"160919121"	"PLA2R1"	"ENSG00000153246"	"Q13018"	""	""	""	""	""	""	""	"Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B."	""	"FALSE"
"10928-7_3"	""	"IL-1F6"	"Interleukin-36 alpha"	"2"	"113763038"	"113765621"	"IL36A"	"ENSG00000136694"	"Q9UHA7"	""	""	""	""	""	""	""	"Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by upregulating surface expression of CD83, CD86 and HLA-DR. In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T-cell proliferation. May play a role in proinflammatory effects in the lung."	""	"FALSE"
"10961-15_3"	""	"TIG3"	"Retinoic acid receptor responder protein 3"	"11"	"63304281"	"63313934"	"RARRES3"	"ENSG00000133321"	"Q9UL19"	""	""	""	""	""	""	""	"Exhibits PLA1/2 activity, catalyzing the calcium-independent hydrolysis of acyl groups in various phosphotidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. N- and O-acylation activity is hardly detectable."	""	"FALSE"
"10962-46_3"	""	"D105A"	"Beta-defensin 105"	"8|8"	"7345191|7679488"	"7347115|7681411"	"DEFB105A|DEFB105A"	"ENSG00000186599|ENSG00000186562"	"Q8NG35|Q8NG35"	""	""	""	""	""	""	""	"Has antibacterial activity."	""	"FALSE"
"10970-3_3"	""	"NAR3"	"Ecto-ADP-ribosyltransferase 3"	"4"	"76932337"	"77033955"	"ART3"	"ENSG00000156219"	"Q13508"	""	""	""	""	""	""	""	"NAD(+) + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine."	""	"FALSE"
"10977-55_3"	""	"UCMA"	"Unique cartilage matrix-associated protein"	"10"	"13263767"	"13276334"	"UCMA"	"ENSG00000165623"	"Q8WVF2"	""	""	""	""	""	""	""	"May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface."	""	"FALSE"
"10990-21_3"	""	"LRRK2"	"Leucine-rich repeat serine/threonine-protein kinase 2"	"12"	"40590546"	"40763087"	"LRRK2"	"ENSG00000188906"	"Q5S007"	""	""	""	""	""	""	""	"Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Plays a role in synaptic vesicle trafficking. Phosphorylates PRDX3. Has GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease."	""	"FALSE"
"11067-13_3"	""	"Osteocalcin"	"Osteocalcin"	"1"	"156211753"	"156213112"	"BGLAP"	"ENSG00000242252"	"P02818"	""	""	""	""	""	""	""	"Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium."	""	"FALSE"
"11083-23_3"	""	"NSE"	"Gamma-enolase"	"12"	"7022909"	"7032861"	"ENO2"	"ENSG00000111674"	"P09104"	""	""	""	""	""	""	""	"Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity)."	""	"FALSE"
"11096-57_3"	""	"HEMK2"	"HemK methyltransferase family member 2"	"21"	"30244513"	"30257693"	"N6AMT1"	"ENSG00000156239"	"Q9Y5N5"	""	""	""	""	""	""	""	"Heterodimeric methyltransferase that catalyzes N5-methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor. ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. May play a role in the modulation of arsenic-induced toxicity. May be involved in the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid."	""	"FALSE"
"11098-1_3"	""	"PDXK"	"Pyridoxal kinase"	"21"	"45138975"	"45182188"	"PDXK"	"ENSG00000160209"	"O00764"	""	""	""	""	""	""	""	"Required for synthesis of pyridoxal-5-phosphate from vitamin B6."	""	"FALSE"
"11102-22_3"	""	"REG4"	"Regenerating islet-derived protein 4"	"1"	"120336641"	"120354283"	"REG4"	"ENSG00000134193"	"Q9BYZ8"	""	""	""	""	""	""	""	"Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium."	""	"FALSE"
"11104-13_3"	""	"YKL-40"	"Chitinase-3-like protein 1"	"1"	"203148059"	"203155877"	"CHI3L1"	"ENSG00000133048"	"P36222"	""	""	""	""	""	""	""	"Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung."	""	"FALSE"
"11109-56_3"	""	"SVEP1"	"Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1"	"9"	"113127531"	"113342160"	"SVEP1"	"ENSG00000165124"	"Q4LDE5"	""	""	""	""	""	""	""	"May play a role in the cell attachment process."	""	"FALSE"
"11117-2_3"	""	"SPT20"	"Spermatogenesis-associated protein 20"	"17"	"48620419"	"48633213"	"SPATA20"	"ENSG00000006282"	"Q8TB22"	""	""	""	""	""	""	""	"May play a role in fertility regulation."	""	"FALSE"
"11120-49_3"	""	"NAT14"	"N-acetyltransferase 14"	"19"	"55996371"	"55998935"	"NAT14"	"ENSG00000090971"	"Q8WUY8"	""	""	""	""	""	""	""	"Probable acetyltransferase that binds the 5'-GGACTACAG-3' sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro."	""	"FALSE"
"11121-56_3"	""	"VWC2"	"Brorin"	"7"	"49813257"	"49961546"	"VWC2"	"ENSG00000188730"	"Q2TAL6"	""	""	""	""	""	""	""	"BMP antagonist which may play a role in neural development. Promotes cell adhesion (By similarity)."	""	"FALSE"
"11122-97_3"	""	"SPG21"	"Maspardin"	"15"	"65255362"	"65282648"	"SPG21"	"ENSG00000090487"	"Q9NZD8"	""	""	""	""	""	""	""	"May play a role as a negative regulatory factor in CD4-dependent T-cell activation."	""	"FALSE"
"11124-9_3"	""	"filamin A"	"Filamin-A"	"X"	"153576892"	"153603006"	"FLNA"	"ENSG00000196924"	"P21333"	""	""	""	""	""	""	""	"Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity)."	""	"FALSE"
"11134-30_3"	""	"RF1ML"	"Peptide chain release factor 1-like, mitochondrial"	"6"	"153308497"	"153323820"	"MTRF1L"	"ENSG00000112031"	"Q9UGC7"	""	""	""	""	""	""	""	"Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons UAA and UAG."	""	"FALSE"
"11138-16_3"	""	"RUNX3"	"Runt-related transcription factor 3"	"1"	"25226002"	"25291612"	"RUNX3"	"ENSG00000020633"	"Q13761"	""	""	""	""	""	""	""	"Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity)."	""	"FALSE"
"11139-4_3"	""	"TRML4"	"Trem-like transcript 4 protein"	"6"	"41196062"	"41206620"	"TREML4"	"ENSG00000188056"	"Q6UXN2"	""	""	""	""	""	""	""	"Positively regulates Toll-like receptor TLR7 signaling in macrophages."	""	"FALSE"
"11140-56_3"	""	"CO1A1"	"Collagen alpha-1(I) chain"	"17"	"48260650"	"48278993"	"COL1A1"	"ENSG00000108821"	"P02452"	""	""	""	""	""	""	""	"Type I collagen is a member of group I collagen (fibrillar forming collagen)."	""	"FALSE"
"11142-11_3"	""	"ANGL1"	"Angiopoietin-related protein 1"	"1"	"178818840"	"178840187"	"ANGPTL1"	"ENSG00000116194"	"O95841"	""	""	""	""	""	""	""	"Secreted"	""	"FALSE"
"11150-3_3"	""	"Collagen a1(VI)"	"Collagen alpha-1(VI) chain"	"21"	"47401651"	"47424964"	"COL6A1"	"ENSG00000142156"	"P12109"	""	""	""	""	""	""	""	"Collagen VI acts as a cell-binding protein."	""	"FALSE"
"11154-3_3"	""	"NF2L1"	"Nuclear factor erythroid 2-related factor 1"	"17"	"46125691"	"46138849"	"NFE2L1"	"ENSG00000082641"	"Q14494"	""	""	""	""	""	""	""	"Endoplasmic reticulum membrane sensor NFE2L1: Endoplasmic reticulum membrane sensor that translocates into the nucleus in response to various stresses to act as a transcription factor (PubMed:20932482, PubMed:24448410). Constitutes a precursor of the transcription factor NRF1 (By similarity). Able to detect various cellular stresses, such as cholesterol excess, oxidative stress or proteasome inhibition (PubMed:20932482). In response to stress, it is released from the endoplasmic reticulum membrane following cleavage by the protease DDI2 and translocates into the nucleus to form the transcription factor NRF1 (By similarity). Acts as a key sensor of cholesterol excess: in excess cholesterol conditions, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, thereby allowing expression of genes promoting cholesterol removal, such as CD36 (By similarity). Involved in proteasome homeostasis: in response to proteasome inhibition, it is released from the endoplasmic reticulum membrane, translocates to the nucleus and activates expression of genes encoding proteasome subunits (PubMed:20932482)."	""	"FALSE"
"11173-29_3"	""	"MILR1"	"Allergin-1"	"17"	"62461569"	"62464760"	"MILR1"	"ENSG00000271605"	"Q7Z6M3"	""	""	""	""	""	""	""	"Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction (By similarity)."	""	"FALSE"
"11175-45_3"	""	"PCAT2"	"Lysophosphatidylcholine acyltransferase 2"	"16"	"55542910"	"55620582"	"LPCAT2"	"ENSG00000087253"	"Q7L5N7"	""	""	""	""	""	""	""	"Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases. Also catalyzes the conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2-diacyl-sn-glycero-3-phosphocholine."	""	"FALSE"
"11178-21_3"	""	"SVEP1"	"Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1"	"9"	"113127531"	"113342160"	"SVEP1"	"ENSG00000165124"	"Q4LDE5"	""	""	""	""	""	""	""	"May play a role in the cell attachment process."	""	"FALSE"
"11187-11_3"	""	"CL12A"	"C-type lectin domain family 12 member A"	"12"	"10103915"	"10148293"	"CLEC12A"	"ENSG00000172322"	"Q5QGZ9"	""	""	""	""	""	""	""	"Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases."	""	"FALSE"
"11203-97_3"	""	"KPYR"	"Pyruvate kinase PKLR"	"1"	"155259630"	"155271225"	"PKLR"	"ENSG00000143627"	"P30613"	""	""	""	""	""	""	""	"Plays a key role in glycolysis."	""	"FALSE"
"11208-15_3"	""	"NAGPA"	"N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase"	"16"	"5074845"	"5084142"	"NAGPA"	"ENSG00000103174"	"Q9UK23"	""	""	""	""	""	""	""	"Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N-acetylglucosaminyltransferases."	""	"FALSE"
"11211-7_3"	""	"TBCE"	"Tubulin-specific chaperone E"	"1"	"235530675"	"235612283"	"TBCE"	"ENSG00000116957"	"Q15813"	""	""	""	""	""	""	""	"Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation. Required for correct organization of microtubule cytoskeleton and mitotic splindle, and maintenance of the neuronal microtubule network."	""	"FALSE"
"11212-7_3"	""	"TXND5"	"Thioredoxin domain-containing protein 5"	"6"	"7881750"	"7911047"	"TXNDC5"	"ENSG00000239264"	"Q8NBS9"	""	""	""	""	""	""	""	"Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast (By similarity)."	""	"FALSE"
"11214-40_3"	""	"DNJB9"	"DnaJ homolog subfamily B member 9"	"7"	"108210012"	"108215294"	"DNAJB9"	"ENSG00000128590"	"Q9UBS3"	""	""	""	""	""	""	""	"Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins (PubMed:18400946). In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similarity). Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production (By similarity)."	""	"FALSE"
"11215-6_3"	""	"CAD15"	"Cadherin-15"	"16"	"89238175"	"89261900"	"CDH15"	"ENSG00000129910"	"P55291"	""	""	""	""	""	""	""	"Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation."	""	"FALSE"
"11222-62_3"	""	"PTPRH"	"Receptor-type tyrosine-protein phosphatase H"	"19"	"55692616"	"55720874"	"PTPRH"	"ENSG00000080031"	"Q9HD43"	""	""	""	""	""	""	""	"Protein phosphatase that may contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin-promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of BCAR1, focal adhesion kinase and SRC. Reduces migratory activity of activity of Jurkat cells. Reduces tyrosine phosphorylation of CEACAM20 and thereby contributes to suppress the intestinal immune response CEACAM20 (By similarity)."	""	"FALSE"
"11228-37_3"	""	"RIC3"	"Protein RIC-3"	"11"	"8127640"	"8190602"	"RIC3"	"ENSG00000166405"	"Q7Z5B4"	""	""	""	""	""	""	""	"Promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface. May also promote functional expression of homomeric serotoninergic 5-HT3 receptors, and of heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4."	""	"FALSE"
"11232-46_3"	""	"TC I"	"Transcobalamin-1"	"11"	"59620273"	"59634048"	"TCN1"	"ENSG00000134827"	"P20061"	""	""	""	""	""	""	""	"Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach."	""	"FALSE"
"11237-49_3"	""	"PCOC1"	"Procollagen C-endopeptidase enhancer 1"	"7"	"100199800"	"100205798"	"PCOLCE"	"ENSG00000106333"	"Q15113"	""	""	""	""	""	""	""	"Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity."	""	"FALSE"
"11243-90_3"	""	"GPR110"	"Adhesion G-protein coupled receptor F1"	"6"	"46965440"	"47010099"	"GPR110"	"ENSG00000153292"	"Q5T601"	""	""	""	""	""	""	""	"Orphan receptor."	""	"FALSE"
"11246-3_3"	""	"LPLC1"	"BPI fold-containing family B member 1"	"20"	"31861286"	"31897684"	"BPIFB1"	"ENSG00000125999"	"Q8TDL5"	""	""	""	""	""	""	""	"May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS."	""	"FALSE"
"11248-43_3"	""	"HEM4"	"Uroporphyrinogen-III synthase"	"10"	"127473549"	"127511817"	"UROS"	"ENSG00000188690"	"P10746"	""	""	""	""	""	""	""	"Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme)."	""	"FALSE"
"11257-1_3"	""	"DHPR"	"Dihydropteridine reductase"	"4"	"17461884"	"17513857"	"QDPR"	"ENSG00000151552"	"P09417"	""	""	""	""	""	""	""	"The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases."	""	"FALSE"
"11260-47_3"	""	"SPA4L"	"SUN domain-containing protein 5"	"20"	"31571579"	"31592239"	"SUN5"	"ENSG00000167098"	"Q8TC36"	""	""	""	""	""	""	""	"Plays an essential role in anchoring sperm head to the tail. Is responsible for the attachment of the coupling apparatus to the sperm nuclear envelope."	""	"FALSE"
"11270-17_3"	""	"CHC10"	"Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial"	"22"	"24108021"	"24110630"	"CHCHD10"	"ENSG00000250479"	"Q8WYQ3"	""	""	""	""	""	""	""	"May be involved in the maintenance of mitochondrial organization and mitochondrial cristae structure."	""	"FALSE"
"11275-94_3"	""	"LRP1B"	"Low-density lipoprotein receptor-related protein 1B"	"2"	"140988992"	"142889270"	"LRP1B"	"ENSG00000168702"	"Q9NZR2"	""	""	""	""	""	""	""	"Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis."	""	"FALSE"
"11276-1_3"	""	"CEP57"	"Centrosomal protein of 57 kDa"	"11"	"95523129"	"95565857"	"CEP57"	"ENSG00000166037"	"Q86XR8"	""	""	""	""	""	""	""	"Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1."	""	"FALSE"
"11277-23_3"	""	"ATF6A"	"Cyclic AMP-dependent transcription factor ATF-6 alpha"	"1"	"161736084"	"161933860"	"ATF6"	"ENSG00000118217"	"P18850"	""	""	""	""	""	""	""	"Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina."	""	"FALSE"
"11278-4_3"	""	"COL11A2"	"Collagen alpha-2(XI) chain"	"6"	"33130458"	"33160276"	"COL11A2"	"ENSG00000204248"	"P13942"	""	""	""	""	""	""	""	"May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils."	""	"FALSE"
"11281-6_3"	""	"GRB7"	"Growth factor receptor-bound protein 7"	"17"	"37894180"	"37903544"	"GRB7"	"ENSG00000141738"	"Q14451"	""	""	""	""	""	""	""	"Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity)."	""	"FALSE"
"11285-8_3"	""	"CD34"	"Hematopoietic progenitor cell antigen CD34"	"1"	"208054317"	"208084747"	"CD34"	"ENSG00000174059"	"P28906"	""	""	""	""	""	""	""	"Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins."	""	"FALSE"
"11286-78_3"	""	"SELS"	"Selenoprotein S"	"15"	"101811022"	"101817705"	"VIMP"	"ENSG00000131871"	"Q9BQE4"	""	""	""	""	""	""	""	"Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination."	""	"FALSE"
"11293-14_3"	""	"LRRN1"	"Leucine-rich repeat neuronal protein 1"	"3"	"3841121"	"3889387"	"LRRN1"	"ENSG00000175928"	"Q6UXK5"	""	""	""	""	""	""	""	"Membrane"	""	"FALSE"
"11308-8_3"	""	"CR3L4"	"Cyclic AMP-responsive element-binding protein 3-like protein 4"	"1"	"153940010"	"153946839"	"CREB3L4"	"ENSG00000143578"	"Q8TEY5"	""	""	""	""	""	""	""	"Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity)."	""	"FALSE"
"11318-20_3"	""	"Apo A-V"	"Apolipoprotein A-V"	"11"	"116660083"	"116663136"	"APOA5"	"ENSG00000110243"	"Q6Q788"	""	""	""	""	""	""	""	"Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages."	""	"FALSE"
"11327-56_3"	""	"CLK2"	"Dual specificity protein kinase CLK2"	"1"	"155232659"	"155248282"	"CLK2"	"ENSG00000176444"	"P49760"	""	""	""	""	""	""	""	"Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells."	""	"FALSE"
"11333-82_3"	""	"RHG25"	"Rho GTPase-activating protein 25"	"2"	"68906733"	"69053965"	"ARHGAP25"	"ENSG00000163219"	"P42331"	""	""	""	""	""	""	""	"GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state."	""	"FALSE"
"11356-19_3"	""	"DGC14"	"Protein DGCR14"	"22"	"19117792"	"19132197"	"DGCR14"	"ENSG00000100056"	"Q96DF8"	""	""	""	""	""	""	""	"May be involved in pre-mRNA splicing."	""	"FALSE"
"11360-39_3"	""	"RRM1"	"Ribonucleoside-diphosphate reductase large subunit"	"11"	"4115937"	"4160106"	"RRM1"	"ENSG00000167325"	"P23921"	""	""	""	""	""	""	""	"Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides."	""	"FALSE"
"11372-2_3"	""	"ZNF18"	"Zinc finger protein 18"	"17"	"11880756"	"11900827"	"ZNF18"	"ENSG00000154957"	"P17022"	""	""	""	""	""	""	""	"May be involved in transcriptional regulation."	""	"FALSE"
"11380-84_3"	""	"RBM24"	"RNA-binding protein 24"	"6"	"17281577"	"17294106"	"RBM24"	"ENSG00000112183"	"Q9BX46"	""	""	""	""	""	""	""	"Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation (PubMed:20977548, PubMed:24375645, PubMed:29358667, PubMed:29104163). Plays a major role in pre-mRNA alternative splicing regulation (PubMed:26990106, PubMed:29104163). Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation (PubMed:29104163). Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing (By similarity). Involved in embryonic stem cell (ESC) transition to cardiac cell differentiation by promoting pre-mRNA alternative splicing events of several pluripotency and/or differentiation genes (PubMed:26990106). Plays a role in the regulation of mRNA stability (PubMed:20977548, PubMed:24356969, PubMed:24375645, PubMed:29104163). Binds to 3'-untranslated region (UTR) AU-rich elements in target transcripts, such as CDKN1A and MYOG, leading to maintain their stabilities (PubMed:20977548, PubMed:24356969). Involved in myogenic differentiation by regulating MYOG levels (PubMed:20977548). Binds to multiple regions in the mRNA 3'-UTR of TP63 isoform 2, hence inducing its destabilization (PubMed:24375645). Promotes also the destabilization of the CHRM2 mRNA via its binding to a region in the coding sequence (PubMed:29104163). Plays a role in the regulation of mRNA translation (PubMed:29358667). Mediates repression of p53/TP53 mRNA translation through its binding to U-rich element in the 3'-UTR, hence preventing EIF4E from binding to p53/TP53 mRNA and translation initiation (PubMed:29358667). Binds to a huge amount of mRNAs (PubMed:29104163). Required for embryonic heart development, sarcomer and M-band formation in striated muscles (By similarity)."	""	"FALSE"
"11382-5_3"	""	"BIEA"	"Biliverdin reductase A"	"7"	"43798279"	"43846941"	"BLVRA"	"ENSG00000106605"	"P53004"	""	""	""	""	""	""	""	"Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor."	""	"FALSE"
"11402-17_3"	""	"KMT2C"	"Histone-lysine N-methyltransferase 2C"	"7"	"151832007"	"152133090"	"KMT2C"	"ENSG00000055609"	"Q8NEZ4"	""	""	""	""	""	""	""	"Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder."	""	"FALSE"
"11424-4_3"	""	"FAAA"	"Fumarylacetoacetase"	"15"	"80444832"	"80479288"	"FAH"	"ENSG00000103876"	"P16930"	""	""	""	""	""	""	""	"4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate."	""	"FALSE"
"11429-80_3"	""	"hnRNP C1/C2"	"Heterogeneous nuclear ribonucleoproteins C1/C2"	"14"	"21677295"	"21737653"	"HNRNPC"	"ENSG00000092199"	"P07910"	""	""	""	""	""	""	""	"Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671)."	""	"FALSE"
"11438-6_3"	""	"DNJB2"	"DnaJ homolog subfamily B member 2"	"2"	"220143989"	"220151622"	"DNAJB2"	"ENSG00000135924"	"P25686"	""	""	""	""	""	""	""	"Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family (PubMed:7957263, PubMed:22219199). In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins (PubMed:15936278, PubMed:21625540). Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes (PubMed:12754272, PubMed:20889486, PubMed:21719532, PubMed:22396390, PubMed:24023695). Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins (PubMed:15936278)."	""	"FALSE"
"11439-88_3"	""	"RHPN2"	"Rhophilin-2"	"19"	"33469499"	"33555794"	"RHPN2"	"ENSG00000131941"	"Q8IUC4"	""	""	""	""	""	""	""	"Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity."	""	"FALSE"
"11440-58_3"	""	"SOCS-3"	"Suppressor of cytokine signaling 3"	"17"	"76352859"	"76356158"	"SOCS3"	"ENSG00000184557"	"O14543"	""	""	""	""	""	""	""	"SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity)."	""	"FALSE"
"11441-11_3"	""	"PYGL"	"Glycogen phosphorylase, liver form"	"14"	"51324609"	"51411454"	"PYGL"	"ENSG00000100504"	"P06737"	""	""	""	""	""	""	""	"Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties."	""	"FALSE"
"11454-87_3"	""	"EIF3G"	"Eukaryotic translation initiation factor 3 subunit G"	"19"	"10225693"	"10230596"	"EIF3G"	"ENSG00000130811"	"O75821"	""	""	""	""	""	""	""	"RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). This subunit can bind 18S rRNA."	""	"FALSE"
"11458-30_3"	""	"PCBP1"	"Poly(rC)-binding protein 1"	"2"	"70314586"	"70316335"	"PCBP1"	"ENSG00000169564"	"Q15365"	""	""	""	""	""	""	""	"Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943)."	""	"FALSE"
"11459-81_3"	""	"ELL"	"RNA polymerase II elongation factor ELL"	"19"	"18553473"	"18632937"	"ELL"	"ENSG00000105656"	"P55199"	""	""	""	""	""	""	""	"Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (PubMed:23932780). ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation."	""	"FALSE"
"11464-9_3"	""	"RELB"	"Transcription factor RelB"	"19"	"45504688"	"45541456"	"RELB"	"ENSG00000104856"	"Q01201"	""	""	""	""	""	""	""	"NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52. Is required for both T and B lymphocyte maturation and function (PubMed:26385063)."	""	"FALSE"
"11465-4_3"	""	"GP135"	"Probable G-protein coupled receptor 135"	"14"	"59895740"	"59932060"	"GPR135"	"ENSG00000181619"	"Q8IZ08"	""	""	""	""	""	""	""	"Orphan receptor. Has spontaneous activity for beta-arrestin recruitment (PubMed:28827538). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538)."	""	"FALSE"
"11476-43_3"	""	"VPS4A"	"Vacuolar protein sorting-associated protein 4A"	"16"	"69345259"	"69360842"	"VPS4A"	"ENSG00000132612"	"Q9UN37"	""	""	""	""	""	""	""	"Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Involved in cytokinesis: retained at the midbody by ZFYVE19/ANCHR and CHMP4C until abscission checkpoint signaling is terminated at late cytokinesis. It is then released following dephosphorylation of CHMP4C, leading to abscission (PubMed:24814515). VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413)."	""	"FALSE"
"11480-1_3"	""	"Aldehyde dehydrogenase, class 3"	"Aldehyde dehydrogenase, dimeric NADP-preferring"	"17"	"19641297"	"19652256"	"ALDH3A1"	"ENSG00000108602"	"P30838"	""	""	""	""	""	""	""	"ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:1737758). Preferentially oxidizes aromatic aldehyde substrates (PubMed:1737758). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity)."	""	"FALSE"
"11490-42_3"	""	"UBL4A"	"Ubiquitin-like protein 4A"	"X"	"153712056"	"153715009"	"UBL4A"	"ENSG00000102178"	"P11441"	""	""	""	""	""	""	""	"As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:28104892, PubMed:25535373). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303)."	""	"FALSE"
"11510-31_3"	""	"Apo L1"	"Apolipoprotein L1"	"22"	"36649056"	"36663576"	"APOL1"	"ENSG00000100342"	"O14791"	""	""	""	""	""	""	""	"May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver."	""	"FALSE"
"11514-196_3"	""	"CD59"	"CD59 glycoprotein"	"11"	"33719807"	"33757991"	"CD59"	"ENSG00000085063"	"P13987"	""	""	""	""	""	""	""	"Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase."	""	"FALSE"
"11516-7_3"	""	"FABPL"	"Fatty acid-binding protein, liver"	"2"	"88422501"	"88427635"	"FABP1"	"ENSG00000163586"	"P07148"	""	""	""	""	""	""	""	"Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes (PubMed:25732850). Binds cholesterol (PubMed:25732850). Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity)."	""	"FALSE"
"11542-11_3"	""	"TM230"	"Transmembrane protein 230"	"20"	"5048878"	"5093749"	"TMEM230"	"ENSG00000089063"	"Q96A57"	""	""	""	""	""	""	""	"Involved in trafficking and recycling of synaptic vesicles."	""	"FALSE"
"11561-32_3"	""	"RN165"	"RING finger protein 165"	"18"	"43906772"	"44043103"	"RNF165"	"ENSG00000141622"	"Q6ZSG1"	""	""	""	""	""	""	""	"E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL."	""	"FALSE"
"11563-51_3"	""	"SYTL4"	"Synaptotagmin-like protein 4"	"X"	"99929488"	"99987110"	"SYTL4"	"ENSG00000102362"	"Q96C24"	""	""	""	""	""	""	""	"Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity)."	""	"FALSE"
"11571-75_3"	""	"NKG2E"	"NKG2-E type II integral membrane protein"	"12"	"10564911"	"10573194"	"KLRC3"	"ENSG00000205810"	"Q07444"	""	""	""	""	""	""	""	"Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells."	""	"FALSE"
"11586-2_3"	""	"LRRN1"	"Leucine-rich repeat neuronal protein 1"	"3"	"3841121"	"3889387"	"LRRN1"	"ENSG00000175928"	"Q6UXK5"	""	""	""	""	""	""	""	"Membrane"	""	"FALSE"
"11587-5_3"	""	"MGAP"	"MAX gene-associated protein"	"15"	"41913422"	"42065279"	"MGA"	"ENSG00000174197"	"Q8IWI9"	""	""	""	""	""	""	""	"Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor (By similarity)."	""	"FALSE"
"11590-5_3"	""	"RBM23"	"Probable RNA-binding protein 23"	"14"	"23362415"	"23388393"	"RBM23"	"ENSG00000100461"	"Q86U06"	""	""	""	""	""	""	""	"Probable RNA-binding protein. May be involved in pre-mRNA splicing process."	""	"FALSE"
"11592-1_3"	""	"ELAV1"	"ELAV-like protein 1"	"19"	"8023463"	"8509925"	"ELAVL1"	"ENSG00000066044"	"Q15717"	""	""	""	""	""	""	""	"RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462). Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:8626503, PubMed:17632515, PubMed:18285462, PubMed:23519412). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity)."	""	"FALSE"
"11601-26_3"	""	"DHX8"	"ATP-dependent RNA helicase DHX8"	"17"	"41561233"	"41621831"	"DHX8"	"ENSG00000067596"	"Q14562"	""	""	""	""	""	""	""	"Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346). Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (PubMed:8608946)."	""	"FALSE"
"11607-15_3"	""	"BRD1"	"Bromodomain-containing protein 1"	"22"	"50166931"	"50221160"	"BRD1"	"ENSG00000100425"	"O95696"	""	""	""	""	""	""	""	"Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity."	""	"FALSE"
"11614-29_3"	""	"ERH"	"Enhancer of rudimentary homolog"	"14"	"69846840"	"69865344"	"ERH"	"ENSG00000100632"	"P84090"	""	""	""	""	""	""	""	"May have a role in the cell cycle."	""	"FALSE"
"11626-7_3"	""	"UB2V1"	"Ubiquitin-conjugating enzyme E2 variant 1"	"20"	"48697661"	"48732496"	"UBE2V1"	"ENSG00000244687"	"Q13404"	""	""	""	""	""	""	""	"Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes."	""	"FALSE"
"11633-89_3"	""	"AHSA1"	"Activator of 90 kDa heat shock protein ATPase homolog 1"	"14"	"77924213"	"77935817"	"AHSA1"	"ENSG00000100591"	"O95433"	""	""	""	""	""	""	""	"Acts as a co-chaperone of HSP90AA1 (PubMed:29127155). Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity (PubMed:29127155). Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155)."	""	"FALSE"
"11643-73_3"	""	"DTX3L"	"E3 ubiquitin-protein ligase DTX3L"	"3"	"122283085"	"122294050"	"DTX3L"	"ENSG00000163840"	"Q8TDB6"	""	""	""	""	""	""	""	"E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses (PubMed:12670957, PubMed:19818714, PubMed:26479788, PubMed:23230272). Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4 (PubMed:28525742). In response to DNA damage, mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1) (PubMed:19818714). The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me) (PubMed:19818714). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). By monoubiquitinating histone H2B HIST1H2BH/H2BJ and thereby promoting chromatin remodeling, positively regulates STAT1-dependent interferon-stimulated gene transcription and thus STAT1-mediated control of viral replication (PubMed:26479788). Independently of its catalytic activity, promotes the sorting of chemokine receptor CXCR4 from early endosome to lysosome following CXCL12 stimulation by reducing E3 ligase ITCH activity and thus ITCH-mediated ubiquitination of endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (PubMed:24790097). In addition, required for the recruitment of HGS and STAM to early endosomes (PubMed:24790097). In association with PARP9, plays a role in antiviral responses by mediating 'Lys-48'-linked ubiquitination of encephalomyocarditis virus (EMCV) and human rhinovirus (HRV) C3 proteases and thus promoting their proteosomal-mediated degradation (PubMed:26479788)."	""	"FALSE"
"11646-4_3"	""	"Carbohydrate sulfotransferase 9"	"Carbohydrate sulfotransferase 9"	"18"	"24486445"	"24765281"	"CHST9"	"ENSG00000154080"	"Q7L1S5"	""	""	""	""	""	""	""	"Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta. Isoform 2, but not isoform 1, is active toward chondroitin."	""	"FALSE"
"11649-3_3"	""	"SMAP1"	"Stromal membrane-associated protein 1"	"6"	"71377479"	"71571718"	"SMAP1"	"ENSG00000112305"	"Q8IYB5"	""	""	""	""	""	""	""	"GTPase activating protein that acts on ARF6. Plays a role in clathrin-dependent endocytosis. May play a role in erythropoiesis (By similarity)."	""	"FALSE"
"11654-77_3"	""	"NRSN1"	"Neurensin-1"	"6"	"24126350"	"24155128"	"NRSN1"	"ENSG00000152954"	"Q8IZ57"	""	""	""	""	""	""	""	"May play an important role in neural organelle transport, and in transduction of nerve signals or in nerve growth. May play a role in neurite extension. May play a role in memory consolidation (By similarity)."	""	"FALSE"
"11656-110_3"	""	"EVL"	"Ena/VASP-like protein"	"14"	"100437786"	"100610573"	"EVL"	"ENSG00000196405"	"Q9UI08"	""	""	""	""	""	""	""	"Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization."	""	"FALSE"
"11659-31_3"	""	"EPN4"	"Clathrin interactor 1"	"5"	"157212751"	"157286183"	"CLINT1"	"ENSG00000113282"	"Q14677"	""	""	""	""	""	""	""	"Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly."	""	"FALSE"
"11664-32_3"	""	"ARFG2"	"ADP-ribosylation factor GTPase-activating protein 2"	"11"	"47185850"	"47198676"	"ARFGAP2"	"ENSG00000149182"	"Q8N6H7"	""	""	""	""	""	""	""	"GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes."	""	"FALSE"
"11666-72_3"	""	"RGS8"	"Regulator of G-protein signaling 8"	"1"	"182610951"	"182653711"	"RGS8"	"ENSG00000135824"	"P57771"	""	""	""	""	""	""	""	"Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:18434541). Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling (By similarity)."	""	"FALSE"
"11667-29_3"	""	"TENC1"	"Tensin-2"	"12"	"53440753"	"53458156"	"TENC1"	"ENSG00000111077"	"Q63HR2"	""	""	""	""	""	""	""	"Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling."	""	"FALSE"
"11672-17_3"	""	"KI16B"	"Kinesin-like protein KIF16B"	"20"	"16252749"	"16554078"	"KIF16B"	"ENSG00000089177"	"Q96L93"	""	""	""	""	""	""	""	"Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development."	""	"FALSE"
"11681-8_3"	""	"NUPL"	"Arf-GAP domain and FG repeat-containing protein 1"	"2"	"228336868"	"228425930"	"AGFG1"	"ENSG00000173744"	"P52594"	""	""	""	""	""	""	""	"Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication."	""	"FALSE"
"11683-19_3"	""	"GGA3"	"ADP-ribosylation factor-binding protein GGA3"	"17"	"73232694"	"73258444"	"GGA3"	"ENSG00000125447"	"Q9NZ52"	""	""	""	""	""	""	""	"Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif."	""	"FALSE"
"11690-47_3"	""	"APC7"	"Anaphase-promoting complex subunit 7"	"12"	"110810705"	"110841535"	"ANAPC7"	"ENSG00000196510"	"Q9UJX3"	""	""	""	""	""	""	""	"Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains."	""	"FALSE"
"11895-21_3"	""	"EMILIN-3"	"Multimerin-2"	"10"	"88695297"	"88729238"	"MMRN2"	"ENSG00000173269"	"Q9H8L6"	""	""	""	""	""	""	""	"Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it downregulates KDR activation by binding VEGFA."	""	"FALSE"
"11939-11_3"	""	"PHLD"	"Phosphatidylinositol-glycan-specific phospholipase D"	"6"	"24424793"	"24495433"	"GPLD1"	"ENSG00000112293"	"P80108"	""	""	""	""	""	""	""	"This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane."	""	"FALSE"
"11952-1_3"	""	"IGDC3"	"Immunoglobulin superfamily DCC subclass member 3"	"15"	"65619465"	"65670378"	"IGDCC3"	"ENSG00000174498"	"Q8IVU1"	""	""	""	""	""	""	""	"Membrane"	""	"FALSE"
"11967-23_3"	""	"RABP1"	"Cellular retinoic acid-binding protein 1"	"15"	"78632666"	"78640572"	"CRABP1"	"ENSG00000166426"	"P29762"	""	""	""	""	""	""	""	"Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors."	""	"FALSE"
"11989-35_3"	""	"EMC1"	"ER membrane protein complex subunit 1"	"1"	"19542158"	"19578046"	"EMC1"	"ENSG00000127463"	"Q8N766"	""	""	""	""	""	""	""	"Component of the ER membrane protein complex (EMC)."	""	"FALSE"
"11993-227_3"	""	"AT1A1"	"Sodium/potassium-transporting ATPase subunit alpha-1"	"1"	"116915290"	"116952883"	"ATP1A1"	"ENSG00000163399"	"P05023"	""	""	""	""	""	""	""	"This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients."	""	"FALSE"
"12016-60_3"	""	"CBL"	"E3 ubiquitin-protein ligase CBL"	"11"	"119076752"	"119178859"	"CBL"	"ENSG00000110395"	"P22681"	""	""	""	""	""	""	""	"Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3."	""	"FALSE"
"12022-12_3"	""	"SMAD4"	"Mothers against decapentaplegic homolog 4"	"18"	"48554764"	"48611415"	"SMAD4"	"ENSG00000141646"	"Q13485"	""	""	""	""	""	""	""	"In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (By similarity). Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator."	""	"FALSE"
"12033-3_3"	""	"BUB1"	"Mitotic checkpoint serine/threonine-protein kinase BUB1"	"2"	"111395275"	"111435691"	"BUB1"	"ENSG00000169679"	"O43683"	""	""	""	""	""	""	""	"Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis."	""	"FALSE"
"12041-33_3"	""	"HS71L"	"Heat shock 70 kDa protein 1-like"	"6"	"31777396"	"31782842"	"HSPA1L"	"ENSG00000204390"	"P34931"	""	""	""	""	""	""	""	"Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810)."	""	"FALSE"
"12333-87_3"	""	"RPIA"	"Ribose-5-phosphate isomerase"	"2"	"88991162"	"89050452"	"RPIA"	"ENSG00000153574"	"P49247"	""	""	""	""	""	""	""	"D-ribose 5-phosphate = D-ribulose 5-phosphate."	""	"FALSE"
"12340-17_3"	""	"SYAC"	"Alanine--tRNA ligase, cytoplasmic"	"16"	"70286198"	"70323446"	"AARS"	"ENSG00000090861"	"P49588"	""	""	""	""	""	""	""	"Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala) (PubMed:28493438). Also edits incorrectly charged tRNA(Ala) via its editing domain (PubMed:28493438)."	""	"FALSE"
"12343-14_3"	""	"CENB2"	"Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2"	"3"	"194995465"	"195163807"	"ACAP2"	"ENSG00000114331"	"Q15057"	""	""	""	""	""	""	""	"GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6)."	""	"FALSE"
"12350-86_3"	""	"ETS2"	"Protein C-ets-2"	"21"	"40177231"	"40196879"	"ETS2"	"ENSG00000157557"	"P15036"	""	""	""	""	""	""	""	"Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription."	""	"FALSE"
"12351-25_3"	""	"STAT1"	"Signal transducer and activator of transcription 1-alpha/beta"	"2"	"191829084"	"191885686"	"STAT1"	"ENSG00000115415"	"P42224"	""	""	""	""	""	""	""	"Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus (PubMed:28753426). ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated (PubMed:26479788). It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4."	""	"FALSE"
"12358-6_3"	""	"IGBP1"	"Immunoglobulin-binding protein 1"	"X"	"69353299"	"69386174"	"IGBP1"	"ENSG00000089289"	"P78318"	""	""	""	""	""	""	""	"Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits."	""	"FALSE"
"12370-30_3"	""	"Apo F"	"Apolipoprotein F"	"12"	"56754353"	"56756607"	"APOF"	"ENSG00000175336"	"Q13790"	""	""	""	""	""	""	""	"Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII."	""	"FALSE"
"12373-73_3"	""	"TRA2B"	"Transformer-2 protein homolog beta"	"3"	"185633694"	"185655924"	"TRA2B"	"ENSG00000136527"	"P62995"	""	""	""	""	""	""	""	"Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA."	""	"FALSE"
"12378-71_3"	""	"TPSN"	"Tapasin"	"6"	"33267471"	"33282164"	"TAPBP"	"ENSG00000231925"	"O15533"	""	""	""	""	""	""	""	"Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading)."	""	"FALSE"
"12381-26_3"	""	"CBR1"	"Carbonyl reductase [NADPH] 1"	"21"	"37442239"	"37445464"	"CBR1"	"ENSG00000159228"	"P16152"	""	""	""	""	""	""	""	"NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione."	""	"FALSE"
"12382-2_3"	""	"DDX58"	"Probable ATP-dependent RNA helicase DDX58"	"9"	"32455703"	"32526322"	"DDX58"	"ENSG00000107201"	"O95786"	""	""	""	""	""	""	""	"Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include: 5'-triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length). In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity. A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity. Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae: Human respiratory syncytial virus and measles virus (MeV), Rhabdoviridae: vesicular stomatitis virus (VSV), Orthomyxoviridae: influenza A and B virus, Flaviviridae: Japanese encephalitis virus (JEV), hepatitis C virus (HCV), dengue virus (DENV) and west Nile virus (WNV). It also detects rotavirus and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome such as Epstein-Barr virus (EBV). Detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). May play important roles in granulocyte production and differentiation, bacterial phagocytosis and in the regulation of cell migration."	""	"FALSE"
"12392-30_3"	""	"ARL1"	"ADP-ribosylation factor-like protein 1"	"12"	"101786898"	"101801598"	"ARL1"	"ENSG00000120805"	"P40616"	""	""	""	""	""	""	""	"GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus."	""	"FALSE"
"12415-122_3"	""	"EDF1"	"Endothelial differentiation-related factor 1"	"9"	"139756571"	"139760738"	"EDF1"	"ENSG00000107223"	"O60869"	""	""	""	""	""	""	""	"Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism."	""	"FALSE"
"12420-10_3"	""	"GPD1L"	"Glycerol-3-phosphate dehydrogenase 1-like protein"	"3"	"32147181"	"32210205"	"GPD1L"	"ENSG00000152642"	"Q8N335"	""	""	""	""	""	""	""	"Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L."	""	"FALSE"
"12422-143_3"	""	"LX15B"	"Arachidonate 15-lipoxygenase B"	"17"	"7942335"	"7952452"	"ALOX15B"	"ENSG00000179593"	"O15296"	""	""	""	""	""	""	""	"Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophage differentiation into proatherogenic foam cells."	""	"FALSE"
"12423-38_3"	""	"A1CF"	"APOBEC1 complementation factor"	"10"	"52559169"	"52645435"	"A1CF"	"ENSG00000148584"	"Q9NQ94"	""	""	""	""	""	""	""	"Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay."	""	"FALSE"
"12424-107_3"	""	"THYN1"	"Thymocyte nuclear protein 1"	"11"	"134118173"	"134123264"	"THYN1"	"ENSG00000151500"	"Q9P016"	""	""	""	""	""	""	""	"Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC."	""	"FALSE"
"12425-104_3"	""	"ARF6"	"ADP-ribosylation factor 6"	"14"	"50359810"	"50363772"	"ARF6"	"ENSG00000165527"	"P62330"	""	""	""	""	""	""	""	"GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling (PubMed:11266366, PubMed:21170023, PubMed:16737952, PubMed:7589240, PubMed:18400762). Required for normal completion of mitotic cytokinesis (By similarity). Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers (By similarity). May also modulate vesicle budding and uncoating within the Golgi apparatus. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension (PubMed:14978216). Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization. Regulates surface levels of adherens junction proteins such as CDH1 (By similarity)."	""	"FALSE"
"12427-8_3"	""	"MPIP2"	"M-phase inducer phosphatase 2"	"20"	"3767419"	"3786768"	"CDC25B"	"ENSG00000101224"	"P30305"	""	""	""	""	""	""	""	"Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity."	""	"FALSE"
"12432-23_3"	""	"CYBP"	"Calcyclin-binding protein"	"1"	"174968300"	"174980851"	"CACYBP"	"ENSG00000116161"	"Q9HB71"	""	""	""	""	""	""	""	"May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1)."	""	"FALSE"
"12433-8_3"	""	"ARL11"	"ADP-ribosylation factor-like protein 11"	"13"	"50202435"	"50208008"	"ARL11"	"ENSG00000152213"	"Q969Q4"	""	""	""	""	""	""	""	"May play a role in apoptosis. May act as a tumor suppressor."	""	"FALSE"
"12434-25_3"	""	"K0174"	"IST1 homolog"	"16"	"71879899"	"71965102"	"IST1"	"ENSG00000182149"	"P53990"	""	""	""	""	""	""	""	"ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129479, PubMed:19129480). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888)."	""	"FALSE"
"12436-84_3"	""	"GST omega-1"	"Glutathione S-transferase omega-1"	"10"	"105995114"	"106027217"	"GSTO1"	"ENSG00000148834"	"P78417"	""	""	""	""	""	""	""	"Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid."	""	"FALSE"
"12438-127_3"	""	"3MG"	"DNA-3-methyladenine glycosylase"	"16"	"127006"	"135852"	"MPG"	"ENSG00000103152"	"P29372"	""	""	""	""	""	""	""	"Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions."	""	"FALSE"
"12446-49_3"	""	"GST A1-1"	"Glutathione S-transferase A1"	"6"	"52656462"	"52668708"	"GSTA1"	"ENSG00000243955"	"P08263"	""	""	""	""	""	""	""	"Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles."	""	"FALSE"
"12449-16_3"	""	"PPIH"	"Peptidyl-prolyl cis-trans isomerase H"	"1"	"43124096"	"43142429"	"PPIH"	"ENSG00000171960"	"O43447"	""	""	""	""	""	""	""	"PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone."	""	"FALSE"
"12450-42_3"	""	"PMVK"	"Phosphomevalonate kinase"	"1"	"154897210"	"154909467"	"PMVK"	"ENSG00000163344"	"Q15126"	""	""	""	""	""	""	""	"ATP + (R)-5-phosphomevalonate = ADP + (R)-5-diphosphomevalonate."	""	"FALSE"
"12451-62_3"	""	"BACH1"	"Transcription regulator protein BACH1"	"21"	"30566392"	"31003071"	"BACH1"	"ENSG00000156273"	"O14867"	""	""	""	""	""	""	""	"Transcriptional regulator that acts as repressor or activator. Binds, in vitro, to NF-E2 binding sites. Play important roles in coordinating transcription activation and repression by MAFK."	""	"FALSE"
"12453-161_3"	""	"NXF1"	"Nuclear RNA export factor 1"	"11"	"62559595"	"62573774"	"NXF1"	"ENSG00000162231"	"Q9UBU9"	""	""	""	""	""	""	""	"Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway) (PubMed:10924507). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex (PubMed:18364396, PubMed:19165146, PubMed:9660949). ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export (PubMed:18364396, PubMed:19165146, PubMed:9660949). Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244)."	""	"FALSE"
"12454-105_3"	""	"NTM1A"	"N-terminal Xaa-Pro-Lys N-methyltransferase 1"	"9"	"132371163"	"132398410"	"NTMT1"	"ENSG00000148335"	"Q9BV86"	""	""	""	""	""	""	""	"Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation (PubMed:24090352). Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1."	""	"FALSE"
"12461-8_3"	""	"SIRT5"	"NAD-dependent protein deacylase sirtuin-5, mitochondrial"	"6"	"13574761"	"13615390"	"SIRT5"	"ENSG00000124523"	"Q9NXA8"	""	""	""	""	""	""	""	"NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693, PubMed:29180469). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062). Activates SHMT2 by mediating its desuccinylation (PubMed:29180469). Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX."	""	"FALSE"
"12463-7_3"	""	"KLH13"	"Kelch-like protein 13"	"X"	"117031776"	"117251303"	"KLHL13"	"ENSG00000003096"	"Q9P2N7"	""	""	""	""	""	""	""	"Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis."	""	"FALSE"
"12471-47_3"	""	"STAU1"	"Double-stranded RNA-binding protein Staufen homolog 1"	"20"	"47729876"	"47804904"	"STAU1"	"ENSG00000124214"	"O95793"	""	""	""	""	""	""	""	"Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site."	""	"FALSE"
"12475-48_3"	""	"CLIC5"	"Chloride intracellular channel protein 5"	"6"	"45866188"	"46048132"	"CLIC5"	"ENSG00000112782"	"Q9NZA1"	""	""	""	""	""	""	""	"Required for normal hearing (PubMed:24781754). It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti (By similarity). Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture (PubMed:15184393, PubMed:18028448, PubMed:20335315)."	""	"FALSE"
"12476-50_3"	""	"TIGAR"	"Fructose-2,6-bisphosphatase TIGAR"	"12"	"4430371"	"4463759"	"TIGAR"	"ENSG00000078237"	"Q9NQ88"	""	""	""	""	""	""	""	"Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate (PubMed:19015259). Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production (PubMed:16839880, PubMed:22887998). Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death (PubMed:16839880, PubMed:19713938, PubMed:23726973, PubMed:22887998, PubMed:23817040). Plays a role in promoting protection against cell death during hypoxia by decreasing mitochondria ROS levels in a HK2-dependent manner through a mechanism that is independent of its fructose-bisphosphatase activity (PubMed:23185017). In response to cardiac damage stress, mediates p53-induced inhibition of myocyte mitophagy through ROS levels reduction and the subsequent inactivation of BNIP3. Reduced mitophagy results in an enhanced apoptotic myocyte cell death, and exacerbates cardiac damage (By similarity). Plays a role in adult intestinal regeneration; contributes to the growth, proliferation and survival of intestinal crypts following tissue ablation (PubMed:23726973). Plays a neuroprotective role against ischemic brain damage by enhancing PPP flux and preserving mitochondria functions (By similarity). Protects glioma cells from hypoxia- and ROS-induced cell death by inhibiting glycolysis and activating mitochondrial energy metabolism and oxygen consumption in a TKTL1-dependent and p53/TP53-independent manner (PubMed:22887998). Plays a role in cancer cell survival by promoting DNA repair through activating PPP flux in a CDK5-ATM-dependent signaling pathway during hypoxia and/or genome stress-induced DNA damage responses (PubMed:25928429). Involved in intestinal tumor progression (PubMed:23726973)."	""	"FALSE"
"12478-15_3"	""	"RL30"	"60S ribosomal protein L30"	"8"	"99037079"	"99058697"	"RPL30"	"ENSG00000156482"	"P62888"	""	""	""	""	""	""	""	"Belongs to the eukaryotic ribosomal protein eL30 family."	""	"FALSE"
"12479-50_3"	""	"KAP1"	"cAMP-dependent protein kinase type I-beta regulatory subunit"	"7"	"588834"	"767287"	"PRKAR1B"	"ENSG00000188191"	"P31321"	""	""	""	""	""	""	""	"Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells."	""	"FALSE"
"12486-8_3"	""	"GLRX2"	"Glutaredoxin-2, mitochondrial"	"1"	"193065598"	"193075244"	"GLRX2"	"ENSG00000023572"	"Q9NS18"	""	""	""	""	""	""	""	"Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release."	""	"FALSE"
"12488-9_3"	""	"MCTS1"	"Malignant T-cell-amplified sequence 1"	"X"	"119727865"	"119754929"	"MCTS1"	"ENSG00000232119"	"Q9ULC4"	""	""	""	""	""	""	""	"Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constitutively expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; up-regulates protein levels of BCL2L2, TFDP1, MRE11, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3. Involved in translation initiation; promotes aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits."	""	"FALSE"
"12490-92_3"	""	"LTOR3"	"Ragulator complex protein LAMTOR3"	"4"	"100799493"	"100815647"	"LAMTOR3"	"ENSG00000109270"	"Q9UHA4"	""	""	""	""	""	""	""	"As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2."	""	"FALSE"
"12494-99_3"	""	"GBRL2"	"Gamma-aminobutyric acid receptor-associated protein-like 2"	"16"	"75600249"	"75611779"	"GABARAPL2"	"ENSG00000034713"	"P60520"	""	""	""	""	""	""	""	"Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation."	""	"FALSE"
"12497-29_3"	""	"SDOS"	"Protein syndesmos"	"16"	"4743695"	"4745860"	"NUDT16L1"	"ENSG00000168101"	"Q9BRJ7"	""	""	""	""	""	""	""	"Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin (PubMed:28241136). In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus (PubMed:28241136). Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs) (PubMed:28241136). Binds U8 snoRNA (PubMed:18820299)."	""	"FALSE"
"12498-12_3"	""	"TX1B3"	"Tax1-binding protein 3"	"17"	"3566190"	"3571976"	"TAX1BP3"	"ENSG00000213977"	"O14907"	""	""	""	""	""	""	""	"May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6."	""	"FALSE"
"12501-10_3"	""	"TBCA"	"Tubulin-specific chaperone A"	"5"	"76986991"	"77164604"	"TBCA"	"ENSG00000171530"	"O75347"	""	""	""	""	""	""	""	"Tubulin-folding protein; involved in the early step of the tubulin folding pathway."	""	"FALSE"
"12508-9_3"	""	"CHMP3"	"Charged multivesicular body protein 3"	"2"	"86730553"	"86847616"	"CHMP3"	"ENSG00000115561"	"Q9Y3E7"	""	""	""	""	""	""	""	"Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor. Isoform 2 prevents stress-mediated cell death and accumulation of reactive oxygen species when expressed in yeast cells."	""	"FALSE"
"12514-16_3"	""	"METTL1"	"tRNA (guanine-N(7)-)-methyltransferase"	"12"	"58162254"	"58166576"	"METTL1"	"ENSG00000037897"	"Q9UBP6"	""	""	""	""	""	""	""	"Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA."	""	"FALSE"
"12517-52_3"	""	"TFAR19"	"Programmed cell death protein 5"	"19"	"33071974"	"33078358"	"PDCD5"	"ENSG00000105185"	"O14737"	""	""	""	""	""	""	""	"May function in the process of apoptosis."	""	"FALSE"
"12522-6_3"	""	"RD23B"	"UV excision repair protein RAD23 homolog B"	"9"	"110045418"	"110094475"	"RAD23B"	"ENSG00000119318"	"P54727"	""	""	""	""	""	""	""	"Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome."	""	"FALSE"
"12529-32_3"	""	"FKBP6"	"Inactive peptidyl-prolyl cis-trans isomerase FKBP6"	"7"	"72742167"	"72772646"	"FKBP6"	"ENSG00000077800"	"O75344"	""	""	""	""	""	""	""	"Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity)."	""	"FALSE"
"12531-5_3"	""	"ERVV1"	"Endogenous retrovirus group V member 1 Env polyprotein"	"19"	"53517174"	"53519375"	"ERVV-1"	"ENSG00000269526"	"B6SEH8"	""	""	""	""	""	""	""	"Membrane"	""	"FALSE"
"12533-135_3"	""	"CYH2"	"Cytohesin-2"	"19"	"48972289"	"48985571"	"CYTH2"	"ENSG00000105443"	"Q99418"	""	""	""	""	""	""	""	"Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP (By similarity). The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (PubMed:17398095). Involved in neurite growth (By similarity)."	""	"FALSE"
"12549-33_3"	""	"PTGD2"	"Hematopoietic prostaglandin D synthase"	"4"	"95219686"	"95264027"	"HPGDS"	"ENSG00000163106"	"O60760"	""	""	""	""	""	""	""	"Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide."	""	"FALSE"
"12554-10_3"	""	"RA51D"	"DNA repair protein RAD51 homolog 4"	"17"	"33419227"	"33448541"	"RAD51D"	"ENSG00000185379"	"O75771"	""	""	""	""	""	""	""	"Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM."	""	"FALSE"
"12560-9_3"	""	"NT5C"	"5'(3')-deoxyribonucleotidase, cytosolic type"	"17"	"73126320"	"73127890"	"NT5C"	"ENSG00000125458"	"Q8TCD5"	""	""	""	""	""	""	""	"Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP."	""	"FALSE"
"12571-14_3"	""	"ARL3"	"ADP-ribosylation factor-like protein 3"	"10"	"104433488"	"104474164"	"ARL3"	"ENSG00000138175"	"P36405"	""	""	""	""	""	""	""	"Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins such as NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium. Does not act as an allosteric activator of the cholera toxin catalytic subunit."	""	"FALSE"
"12574-36_3"	""	"Endothelin 2"	"Endothelin-2"	"1"	"41944446"	"41950344"	"EDN2"	"ENSG00000127129"	"P20800"	""	""	""	""	""	""	""	"Endothelins are endothelium-derived vasoconstrictor peptides."	""	"FALSE"
"12576-21_3"	""	"MAGE-3"	"Melanoma-associated antigen 3"	"X"	"151867230"	"151870825"	"MAGEA3"	"ENSG00000221867"	"P43357"	""	""	""	""	""	""	""	"Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes."	""	"FALSE"
"12590-67_3"	""	"PRB4"	"Basic salivary proline-rich protein 4"	"12"	"11460017"	"11463369"	"PRB4"	"ENSG00000230657"	"P10163"	""	""	""	""	""	""	""	"Secreted"	""	"FALSE"
"12593-33_3"	""	"PDRG1"	"p53 and DNA damage-regulated protein 1"	"20"	"30532145"	"30539895"	"PDRG1"	"ENSG00000088356"	"Q9NUG6"	""	""	""	""	""	""	""	"May play a role in chaperone-mediated protein folding."	""	"FALSE"
"12594-5_3"	""	"GRAN"	"Grancalcin"	"2"	"163175350"	"163228105"	"GCA"	"ENSG00000115271"	"P28676"	""	""	""	""	""	""	""	"Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions."	""	"FALSE"
"12603-87_3"	""	"PABP4"	"Polyadenylate-binding protein 4"	"1"	"40026488"	"40042462"	"PABPC4"	"ENSG00000090621"	"Q13310"	""	""	""	""	""	""	""	"Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity)."	""	"FALSE"
"12604-16_3"	""	"SCMH1"	"Polycomb protein SCMH1"	"1"	"41492872"	"41707826"	"SCMH1"	"ENSG00000010803"	"Q96GD3"	""	""	""	""	""	""	""	"Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes."	""	"FALSE"
"12605-1_3"	""	"Exosome component 3"	"Exosome complex component RRP40"	"9"	"37766975"	"37801434"	"EXOSC3"	"ENSG00000107371"	"Q9NQT5"	""	""	""	""	""	""	""	"Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC3 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC9 and EXOSC5."	""	"FALSE"
"12616-45_3"	""	"NRBP"	"Nuclear receptor-binding protein"	"2"	"27650657"	"27665126"	"NRBP1"	"ENSG00000115216"	"Q9UHY1"	""	""	""	""	""	""	""	"May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication."	""	"FALSE"
"12618-50_3"	""	"Aldo-keto reductase 1C1"	"Aldo-keto reductase family 1 member C1"	"10"	"5005445"	"5149714"	"AKR1C1"	"ENSG00000187134"	"Q04828"	""	""	""	""	""	""	""	"Converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation."	""	"FALSE"
"12630-8_3"	""	"ARFP2"	"Arfaptin-2"	"11"	"6495913"	"6502709"	"ARFIP2"	"ENSG00000132254"	"P53365"	""	""	""	""	""	""	""	"Putative target protein of ADP-ribosylation factor. Involved in membrane ruffling."	""	"FALSE"
"12632-14_3"	""	"ARY1"	"Arylamine N-acetyltransferase 1"	"8"	"18027986"	"18081198"	"NAT1"	"ENSG00000171428"	"P18440"	""	""	""	""	""	""	""	"Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens."	""	"FALSE"
"12633-3_3"	""	"PTN9"	"Tyrosine-protein phosphatase non-receptor type 9"	"15"	"75755592"	"75871630"	"PTPN9"	"ENSG00000169410"	"P43378"	""	""	""	""	""	""	""	"Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus."	""	"FALSE"
"12634-79_3"	""	"BCAR3"	"Breast cancer anti-estrogen resistance protein 3"	"1"	"94027343"	"94312706"	"BCAR3"	"ENSG00000137936"	"O75815"	""	""	""	""	""	""	""	"May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins."	""	"FALSE"
"12643-4_3"	""	"ARRB1"	"Beta-arrestin-1"	"11"	"74975226"	"75062749"	"ARRB1"	"ENSG00000137486"	"P49407"	""	""	""	""	""	""	""	"Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Involved in internalization of P2RY4 and UTP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 ands subsequent recycling. Involved in the degradation of cAMP by recruiting cAMP phosphodiesterases to ligand-activated receptors. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G-protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Acts as signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2). ERK1/2 activated by the beta-arrestin scaffold is largely excluded from the nucleus and confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Recruits c-Src/SRC to ADRB2 resulting in ERK activation. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Inhibits ERK1/2 signaling in AGTR1- and AVPR2-mediated activation (reciprocal regulation). Is required for SP-stimulated endocytosis of NK1R and recruits c-Src/SRC to internalized NK1R resulting in ERK1/2 activation, which is required for the antiapoptotic effects of SP. Is involved in proteinase-activated F2RL1-mediated ERK activity. Acts as signaling scaffold for the AKT1 pathway. Is involved in alpha-thrombin-stimulated AKT1 signaling. Is involved in IGF1-stimulated AKT1 signaling leading to increased protection from apoptosis. Involved in activation of the p38 MAPK signaling pathway and in actin bundle formation. Involved in F2RL1-mediated cytoskeletal rearrangement and chemotaxis. Involved in AGTR1-mediated stress fiber formation by acting together with GNAQ to activate RHOA. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. May serve as nuclear messenger for GPCRs. Involved in OPRD1-stimulated transcriptional regulation by translocating to CDKN1B and FOS promoter regions and recruiting EP300 resulting in acetylation of histone H4. Involved in regulation of LEF1 transcriptional activity via interaction with DVL1 and/or DVL2 Also involved in regulation of receptors other than GPCRs. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN. Binds phosphoinositides. Binds inositolhexakisphosphate (InsP6) (By similarity). Involved in IL8-mediated granule release in neutrophils. Required for atypical chemokine receptor ACKR2-induced RAC1-LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Involved in the internalization of the atypical chemokine receptor ACKR3. Negatively regulates the NOTCH signaling pathway by mediating the ubiquitination and degradation of NOTCH1 by ITCH. Participates to the recruitment of the ubiquitin-protein ligase to the receptor (PubMed:23886940)."	""	"FALSE"
"12644-63_3"	""	"PURA2"	"Adenylosuccinate synthetase isozyme 2"	"1"	"244571796"	"244615436"	"ADSS"	"ENSG00000035687"	"P30520"	""	""	""	""	""	""	""	"Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP."	""	"FALSE"
"12646-2_3"	""	"RPE"	"Ribulose-phosphate 3-epimerase"	"2"	"210867289"	"210886983"	"RPE"	"ENSG00000197713"	"Q96AT9"	""	""	""	""	""	""	""	"Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate."	""	"FALSE"
"12650-43_3"	""	"GNAI3"	"Guanine nucleotide-binding protein G(k) subunit alpha"	"1"	"110091233"	"110160943"	"GNAI3"	"ENSG00000065135"	"P08754"	""	""	""	""	""	""	""	"Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:8774883, PubMed:18434541, PubMed:19478087). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (PubMed:19478087). Stimulates the activity of receptor-regulated K(+) channels (PubMed:2535845). The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division (PubMed:17635935)."	""	"FALSE"
"12653-13_3"	""	"CSNK1G2"	"Casein kinase I isoform gamma-2"	"19"	"1941148"	"1981337"	"CSNK1G2"	"ENSG00000133275"	"P78368"	""	""	""	""	""	""	""	"Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation."	""	"FALSE"
"12655-30_3"	""	"SNAB"	"Beta-soluble NSF attachment protein"	"20"	"23355156"	"23402156"	"NAPB"	"ENSG00000125814"	"Q9H115"	""	""	""	""	""	""	""	"Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus."	""	"FALSE"
"12659-13_3"	""	"GTPB9"	"Obg-like ATPase 1"	"2"	"174937175"	"175113426"	"OLA1"	"ENSG00000138430"	"Q9NTK5"	""	""	""	""	""	""	""	"Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP."	""	"FALSE"
"12661-44_3"	""	"GBRL1"	"Gamma-aminobutyric acid receptor-associated protein-like 1"	"12"	"10365057"	"10375729"	"GABARAPL1"	"ENSG00000139112"	"Q9H0R8"	""	""	""	""	""	""	""	"Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation."	""	"FALSE"
"12663-1_3"	""	"THTR"	"Thiosulfate sulfurtransferase"	"22"	"37406900"	"37416224"	"TST"	"ENSG00000128311"	"Q16762"	""	""	""	""	""	""	""	"Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity (By similarity). Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA."	""	"FALSE"
"12668-7_3"	""	"VPS4B"	"Vacuolar protein sorting-associated protein 4B"	"18"	"61056423"	"61089716"	"VPS4B"	"ENSG00000119541"	"O75351"	""	""	""	""	""	""	""	"Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413)."	""	"FALSE"
"12678-66_3"	""	"SNRPA"	"U1 small nuclear ribonucleoprotein A"	"19"	"41256542"	"41271294"	"SNRPA"	"ENSG00000077312"	"P09012"	""	""	""	""	""	""	""	"Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs."	""	"FALSE"
"12681-63_3"	""	"UBP21"	"Ubiquitin carboxyl-terminal hydrolase 21"	"1"	"161129240"	"161135513"	"USP21"	"ENSG00000143258"	"Q9UK80"	""	""	""	""	""	""	""	"Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates (PubMed:10799498). Deubiquitinates BAZ2A/TIP5 leading to its stabilization (PubMed:26100909)."	""	"FALSE"
"12682-5_3"	""	"KAT3"	"Kynurenine--oxoglutarate transaminase 3"	"1"	"89401456"	"89458636"	"CCBL2"	"ENSG00000137944"	"Q6YP21"	""	""	""	""	""	""	""	"Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro) (By similarity)."	""	"FALSE"
"12684-5_3"	""	"ADSV"	"Adseverin"	"7"	"12610203"	"12699804"	"SCIN"	"ENSG00000006747"	"Q9Y6U3"	""	""	""	""	""	""	""	"Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed:8547642, PubMed:26365202). Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (By similarity). In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (PubMed:11568009). Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (By similarity). Regulates chondrocyte proliferation and differentiation (By similarity). Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (PubMed:11568009)."	""	"FALSE"
"12688-115_3"	""	"KS6A6"	"Ribosomal protein S6 kinase alpha-6"	"X"	"83313354"	"83442915"	"RPS6KA6"	"ENSG00000072133"	"Q9UK32"	""	""	""	""	""	""	""	"Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis."	""	"FALSE"
"12690-33_3"	""	"SEPT10"	"Septin-10"	"2"	"110300559"	"110371783"	"SEPT10"	"ENSG00000186522"	"Q9P0V9"	""	""	""	""	""	""	""	"Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential)."	""	"FALSE"
"12694-28_3"	""	"DIM1"	"Probable dimethyladenosine transferase"	"5"	"61683081"	"61699766"	"DIMT1"	"ENSG00000086189"	"Q9UNQ2"	""	""	""	""	""	""	""	"Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle (PubMed:25851604). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity (PubMed:25851604)."	""	"FALSE"
"12706-2_3"	""	"MRCKA"	"Serine/threonine-protein kinase MRCK alpha"	"1"	"227177566"	"227506175"	"CDC42BPA"	"ENSG00000143776"	"Q5VT25"	""	""	""	""	""	""	""	"Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9418861, PubMed:9092543). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity)."	""	"FALSE"
"12709-63_3"	""	"H1X"	"Histone H1x"	"3"	"129033614"	"129035120"	"H1FX"	"ENSG00000184897"	"Q92522"	""	""	""	""	""	""	""	"Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures."	""	"FALSE"
"12713-365_3"	""	"RGS19"	"Regulator of G-protein signaling 19"	"20"	"62704534"	"62711341"	"RGS19"	"ENSG00000171700"	"P49795"	""	""	""	""	""	""	""	"Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein."	""	"FALSE"
"12716-3_3"	""	"ZN175"	"Zinc finger protein 175"	"19"	"52074551"	"52095761"	"ZNF175"	"ENSG00000105497"	"Q9Y473"	""	""	""	""	""	""	""	"Down-regulates the expression of several chemokine receptors. Interferes with HIV-1 replication by suppressing Tat-induced viral LTR promoter activity."	""	"FALSE"
"12718-43_3"	""	"PIN4"	"Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4"	"X"	"71401203"	"71522776"	"PIN4"	"ENSG00000102309"	"Q9Y237"	""	""	""	""	""	""	""	"Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA."	""	"FALSE"
"12720-71_3"	""	"UBQL4"	"Ubiquilin-4"	"1"	"156005092"	"156023585"	"UBQLN4"	"ENSG00000160803"	"Q9NRR5"	""	""	""	""	""	""	""	"Plays a role in the regulation of protein degradation via the ubiquitin-proteasome system (UPS). Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (Ref. 6). Plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery. Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205)."	""	"FALSE"
"12724-81_3"	""	"CIRBP"	"Cold-inducible RNA-binding protein"	"19"	"1259383"	"1274879"	"CIRBP"	"ENSG00000099622"	"Q14011"	""	""	""	""	""	""	""	"Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed."	""	"FALSE"
"12726-3_3"	""	"RFXAP"	"Regulatory factor X-associated protein"	"13"	"37393361"	"37403241"	"RFXAP"	"ENSG00000133111"	"O00287"	""	""	""	""	""	""	""	"Part of the RFX complex that binds to the X-box of MHC II promoters."	""	"FALSE"
"12727-7_3"	""	"FPRP"	"Prostaglandin F2 receptor negative regulator"	"1"	"117452679"	"117532980"	"PTGFRN"	"ENSG00000134247"	"Q9P2B2"	""	""	""	""	""	""	""	"Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity)."	""	"FALSE"
"12730-3_3"	""	"KNTC2"	"Kinetochore protein NDC80 homolog"	"18"	"2571510"	"2616634"	"NDC80"	"ENSG00000080986"	"O14777"	""	""	""	""	""	""	""	"Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:9315664, PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules (PubMed:25743205, PubMed:23891108)."	""	"FALSE"
"12731-12_3"	""	"PKHA7"	"Pleckstrin homology domain-containing family A member 7"	"11"	"16799842"	"17035990"	"PLEKHA7"	"ENSG00000166689"	"Q6IQ23"	""	""	""	""	""	""	""	"Required for zonula adherens biogenesis and maintenance. Acts via its interaction with KIAA1543/Nezha, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site."	""	"FALSE"
"12738-43_3"	""	"NISCH"	"Nischarin"	"3"	"52489134"	"52527087"	"NISCH"	"ENSG00000010322"	"Q9Y2I1"	""	""	""	""	""	""	""	"Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension (By similarity). Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons (By similarity). Acts as a modulator of Rac-regulated signal transduction pathways (By similarity). Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity (By similarity). Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation (By similarity). Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation (By similarity). Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells (By similarity). Inhibits lamellipodia formation, when overexpressed (By similarity). Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures."	""	"FALSE"
"12747-89_3"	""	"RBM3"	"RNA-binding protein 3"	"X"	"48432837"	"48437454"	"RBM3"	"ENSG00000102317"	"P98179"	""	""	""	""	""	""	""	"Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed. Enhances phosphorylation of translation initiation factors and active polysome formation (By similarity)."	""	"FALSE"
"12753-6_3"	""	"APBB2"	"Amyloid beta A4 precursor protein-binding family B member 2"	"4"	"40812044"	"41218731"	"APBB2"	"ENSG00000163697"	"Q92870"	""	""	""	""	""	""	""	"May modulate the internalization of amyloid-beta precursor protein."	""	"FALSE"
"12758-47_3"	""	"GRID2"	"Glutamate receptor ionotropic, delta-2"	"4"	"93224773"	"94695707"	"GRID2"	"ENSG00000152208"	"O43424"	""	""	""	""	""	""	""	"Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the beta-NRX1-CBLN1-GRID2 triad complex (PubMed:27418511)."	""	"FALSE"
"12761-12_3"	""	"APBB2"	"Amyloid beta A4 precursor protein-binding family B member 2"	"4"	"40812044"	"41218731"	"APBB2"	"ENSG00000163697"	"Q92870"	""	""	""	""	""	""	""	"May modulate the internalization of amyloid-beta precursor protein."	""	"FALSE"
"12775-6_3"	""	"HMGB3"	"High mobility group protein B3"	"X"	"150148982"	"150159248"	"HMGB3"	"ENSG00000029993"	"O15347"	""	""	""	""	""	""	""	"Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor (By similarity). Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling (By similarity)."	""	"FALSE"
"12777-11_3"	""	"SF01"	"Splicing factor 1"	"11"	"64532078"	"64546258"	"SF1"	"ENSG00000168066"	"Q15637"	""	""	""	""	""	""	""	"Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor."	""	"FALSE"
"12783-29_3"	""	"HNRPM"	"Heterogeneous nuclear ribonucleoprotein M"	"19"	"8509651"	"8553998"	"HNRNPM"	"ENSG00000099783"	"P52272"	""	""	""	""	""	""	""	"Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines."	""	"FALSE"
"12800-5_3"	""	"TPPP2"	"Tubulin polymerization-promoting protein family member 2"	"14"	"21492268"	"21504435"	"TPPP2"	"ENSG00000179636"	"P59282"	""	""	""	""	""	""	""	"May bind tubulin but has no microtubule bundling activity."	""	"FALSE"
"12801-33_3"	""	"IRF2"	"Interferon regulatory factor 2"	"4"	"185308867"	"185395734"	"IRF2"	"ENSG00000168310"	"P14316"	""	""	""	""	""	""	""	"Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation."	""	"FALSE"
"12807-89_3"	""	"RHG30"	"Rho GTPase-activating protein 30"	"1"	"161016736"	"161039760"	"ARHGAP30"	"ENSG00000186517"	"Q7Z6I6"	""	""	""	""	""	""	""	"GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42."	""	"FALSE"
"12812-25_3"	""	"ACYP2"	"Acylphosphatase-2"	"2"	"54197975"	"54532437"	"ACYP2"	"ENSG00000170634"	"P14621"	""	""	""	""	""	""	""	"Its physiological role is not yet clear."	""	"FALSE"
"12813-18_3"	""	"EHBP1"	"EH domain-binding protein 1"	"2"	"62900986"	"63273622"	"EHBP1"	"ENSG00000115504"	"Q8NDI1"	""	""	""	""	""	""	""	"May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity)."	""	"FALSE"
"12817-1_3"	""	"GEM"	"GTP-binding protein GEM"	"8"	"95261481"	"95274578"	"GEM"	"ENSG00000164949"	"P55040"	""	""	""	""	""	""	""	"Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity."	""	"FALSE"
"12818-159_3"	""	"UT2"	"Urea transporter 2"	"18"	"42792960"	"43263651"	"SLC14A2"	"ENSG00000132874"	"Q15849"	""	""	""	""	""	""	""	"Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism."	""	"FALSE"
"12830-4_3"	""	"SAP18"	"Histone deacetylase complex subunit SAP18"	"13"	"21714653"	"21723223"	"SAP18"	"ENSG00000150459"	"O00422"	""	""	""	""	""	""	""	"Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function."	""	"FALSE"
"12842-43_3"	""	"STX10"	"Syntaxin-10"	"19"	"13254872"	"13261197"	"STX10"	"ENSG00000104915"	"O60499"	""	""	""	""	""	""	""	"SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network."	""	"FALSE"
"12875-28_3"	""	"UBTD2"	"Ubiquitin domain-containing protein 2"	"5"	"171636644"	"171711075"	"UBTD2"	"ENSG00000168246"	"Q8WUN7"	""	""	""	""	""	""	""	"EBI-12867288"	""	"FALSE"
"12878-60_3"	""	"OSB11"	"Oxysterol-binding protein-related protein 11"	"3"	"125247702"	"125313934"	"OSBPL11"	"ENSG00000144909"	"Q9BXB4"	""	""	""	""	""	""	""	"Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage (PubMed:23028956). Weakly binds 25-hydroxycholesterol (PubMed:17428193)."	""	"FALSE"
"12881-17_3"	""	"RDH16"	"Retinol dehydrogenase 16"	"12"	"57345215"	"57353158"	"RDH16"	"ENSG00000139547"	"O75452"	""	""	""	""	""	""	""	"Oxidoreductase with a preference for NAD. Oxidizes all-trans-retinol and 13-cis-retinol to the corresponding aldehydes. Has higher activity towards CRBP-bound retinol than with free retinol. Oxidizes 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction."	""	"FALSE"
"12885-42_3"	""	"NR1D2"	"Nuclear receptor subfamily 1 group D member 2"	"3"	"23986751"	"24022109"	"NR1D2"	"ENSG00000174738"	"Q14995"	""	""	""	""	""	""	""	"Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARNTL/BMAL1 and CLOCK. Also regulates genes involved in metabolic functions, including lipid metabolism and the inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nuclegotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and also negatively regulates the expression of NR1D1. Regulates lipid and energy homeostasis in the skeletal muscle via repression of genes involved in lipid metabolism and myogenesis including: CD36, FABP3, FABP4, UCP3, SCD1 and MSTN. Regulates hepatic lipid metabolism via the repression of APOC3. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). In addition to its activity as a repressor, can also act as a transcriptional activator. Acts as a transcriptional activator of the sterol regulatory element-binding protein 1 (SREBF1) and the inflammatory mediator interleukin-6 (IL6) in the skeletal muscle."	""	"FALSE"
"12891-1_3"	""	"MILK2"	"MICAL-like protein 2"	"7"	"1468101"	"1499138"	"MICALL2"	"ENSG00000164877"	"Q8IY33"	""	""	""	""	""	""	""	"Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity)."	""	"FALSE"
"12893-159_3"	""	"IP16"	"Gamma-interferon-inducible protein 16"	"1"	"158969758"	"159024945"	"IFI16"	"ENSG00000163565"	"Q16666"	""	""	""	""	""	""	""	"Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer."	""	"FALSE"
"12894-3_3"	""	"PAXI1"	"PAX-interacting protein 1"	"7"	"154735397"	"154794794"	"PAXIP1"	"ENSG00000157212"	"Q6ZW49"	""	""	""	""	""	""	""	"Involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. Plays a role in early development. In DNA damage response is required for cell survival after ionizing radiation. In vitro shown to be involved in the homologous recombination mechanism for the repair of double-strand breaks (DSBs). Its localization to DNA damage foci requires RNF8 and UBE2N. Recruits TP53BP1 to DNA damage foci and, at least in particular repair processes, effective DNA damage response appears to require the association with TP53BP1 phosphorylated by ATM at 'Ser-25'. Together with TP53BP1 regulates ATM association. Proposed to recruit PAGR1 to sites of DNA damage and the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage; the function is probably independent of MLL-containing histone methyltransferase (HMT) complexes. However, this function has been questioned (By similarity). Promotes ubiquitination of PCNA following UV irradiation and may regulate recruitment of polymerase eta and RAD51 to chromatin after DNA damage. Proposed to be involved in transcriptional regulation by linking MLL-containing histone methyltransferase (HMT) complexes to gene promoters by interacting with promoter-bound transcription factors such as PAX2. Associates with gene promoters that are known to be regulated by KMT2D/MLL2. During immunoglobulin class switching in activated B-cells is involved in trimethylation of histone H3 at 'Lys-4' and in transcription initiation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus; this function appears to involve the recruitment of MLL-containing HMT complexes. Conflictingly, its function in transcriptional regulation during immunoglobulin class switching is reported to be independent of the MLL2/MLL3 complex (By similarity)."	""	"FALSE"
"12895-28_3"	""	"DGKB"	"Diacylglycerol kinase beta"	"7"	"14184674"	"15014402"	"DGKB"	"ENSG00000136267"	"Q9Y6T7"	""	""	""	""	""	""	""	"Exhibits high phosphorylation activity for long-chain diacylglycerols."	""	"FALSE"
"12908-15_3"	""	"Apo A-V"	"Apolipoprotein A-V"	"11"	"116660083"	"116663136"	"APOA5"	"ENSG00000110243"	"Q6Q788"	""	""	""	""	""	""	""	"Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages."	""	"FALSE"
"12931-16_3"	""	"MCR"	"Mineralocorticoid receptor"	"4"	"148999913"	"149365850"	"NR3C2"	"ENSG00000151623"	"P08235"	""	""	""	""	""	""	""	"Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels."	""	"FALSE"
"12936-38_3"	""	"RLBP1"	"Retinaldehyde-binding protein 1"	"15"	"89753100"	"89764982"	"RLBP1"	"ENSG00000140522"	"P12271"	""	""	""	""	""	""	""	"Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'."	""	"FALSE"
"12939-1_3"	""	"RPAC1"	"DNA-directed RNA polymerases I and III subunit RPAC1"	"6"	"43477440"	"43497323"	"POLR1C"	"ENSG00000171453"	"O15160"	""	""	""	""	""	""	""	"DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity)."	""	"FALSE"
"12940-35_3"	""	"AL3B1"	"Aldehyde dehydrogenase family 3 member B1"	"11"	"67776048"	"67796749"	"ALDH3B1"	"ENSG00000006534"	"P43353"	""	""	""	""	""	""	""	"Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. May use both NADP(+) and NAD(+) as cofactors. May have a protective role against the cytotoxicity induced by lipid peroxidation."	""	"FALSE"
"12960-9_3"	""	"HXK4"	"Glucokinase"	"7"	"44183870"	"44237769"	"GCK"	"ENSG00000106633"	"P35557"	""	""	""	""	""	""	""	"Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage."	""	"FALSE"
"12970-35_3"	""	"STAU2"	"Double-stranded RNA-binding protein Staufen homolog 2"	"8"	"74332604"	"74659943"	"STAU2"	"ENSG00000040341"	"Q9NUL3"	""	""	""	""	""	""	""	"RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity)."	""	"FALSE"
"12987-12_3"	""	"SRSF7"	"Serine/arginine-rich splicing factor 7"	"2"	"38970741"	"38978636"	"SRSF7"	"ENSG00000115875"	"Q16629"	""	""	""	""	""	""	""	"Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific."	""	"FALSE"
"12988-49_3"	""	"EWS"	"RNA-binding protein EWS"	"22"	"29663998"	"29696515"	"EWSR1"	"ENSG00000182944"	"Q01844"	""	""	""	""	""	""	""	"Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes."	""	"FALSE"
"12990-39_3"	""	"MAP3K3"	"Mitogen-activated protein kinase kinase kinase 3"	"17"	"61699775"	"61773663"	"MAP3K3"	"ENSG00000198909"	"Q99759"	""	""	""	""	""	""	""	"Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators."	""	"FALSE"
"12993-21_3"	""	"NPL4"	"Nuclear protein localization protein 4 homolog"	"17"	"79523913"	"79615495"	"NPLOC4"	"ENSG00000182446"	"Q8TAT6"	""	""	""	""	""	""	""	"The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729)."	""	"FALSE"
"13007-66_3"	""	"LCN10"	"Epididymal-specific lipocalin-10"	"9"	"139632619"	"139637808"	"LCN10"	"ENSG00000187922"	"Q6JVE6"	""	""	""	""	""	""	""	"May play a role in male fertility. May act as a retinoid carrier protein within the epididymis."	""	"FALSE"
"13022-20_3"	""	"P5I11"	"Tumor protein p53-inducible protein 11"	"11"	"44907454"	"44972857"	"TP53I11"	"ENSG00000175274"	"O14683"	""	""	""	""	""	""	""	"Membrane"	""	"FALSE"
"13023-8_3"	""	"APRV1"	"Retroviral-like aspartic protease 1"	"2"	"70187221"	"70189397"	"ASPRV1"	"ENSG00000244617"	"Q53RT3"	""	""	""	""	""	""	""	"Homodimer."	""	"FALSE"
"13027-20_3"	""	"CBX7"	"Chromobox protein homolog 7"	"22"	"39516172"	"39548679"	"CBX7"	"ENSG00000100307"	"O95931"	""	""	""	""	""	""	""	"Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity."	""	"FALSE"
"13028-2_3"	""	"EVI2B"	"Protein EVI2B"	"17"	"29630784"	"29641130"	"EVI2B"	"ENSG00000185862"	"P34910"	""	""	""	""	""	""	""	"Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor cells."	""	"FALSE"
"13053-6_3"	""	"S6A14"	"Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)"	"X"	"115567790"	"115592625"	"SLC6A14"	"ENSG00000268104"	"Q9UN76"	""	""	""	""	""	""	""	"Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner."	""	"FALSE"
"13055-53_3"	""	"PSD1"	"PH and SEC7 domain-containing protein 1"	"10"	"104162374"	"104181296"	"PSD"	"ENSG00000059915"	"A5PKW4"	""	""	""	""	""	""	""	"Guanine nucleotide exchange factor for ARF6 (PubMed:23603394). Induces cytoskeletal remodeling (By similarity)."	""	"FALSE"
"13059-33_3"	""	"RIFK"	"Riboflavin kinase"	"9"	"79000433"	"79009433"	"RFK"	"ENSG00000135002"	"Q969G6"	""	""	""	""	""	""	""	"Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase."	""	"FALSE"
"13062-4_3"	""	"GMFG"	"Glia maturation factor gamma"	"19"	"39818993"	"39833012"	"GMFG"	"ENSG00000130755"	"O60234"	""	""	""	""	""	""	""	"Expressed predominantly in lung, heart and placenta."	""	"FALSE"
"13067-5_3"	""	"KGP1B"	"cGMP-dependent protein kinase 1, beta isozyme"	"10"	"52751118"	"54058110"	"PRKG1"	"ENSG00000185532"	"Q13976"	""	""	""	""	""	""	""	"Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via several pathways: phosphorylates MRVI1/IRAG and inhibits IP3-induced Ca(2+) release from intracellular stores, phosphorylation of KCNMA1 (BKCa) channels decreases intracellular Ca(2+) levels, which leads to increased opening of this channel. PRKG1 phosphorylates the canonical transient receptor potential channel (TRPC) family which inactivates the associated inward calcium current. Another mode of action of NO/cGMP/PKGI signaling involves PKGI-mediated inactivation of the Ras homolog gene family member A (RhoA). Phosphorylation of RHOA by PRKG1 blocks the action of this protein in myriad processes: regulation of RHOA translocation; decreasing contraction; controlling vesicle trafficking, reduction of myosin light chain phosphorylation resulting in vasorelaxation. Activation of PRKG1 by NO signaling alters also gene expression in a number of tissues. In smooth muscle cells, increased cGMP and PRKG1 activity influence expression of smooth muscle-specific contractile proteins, levels of proteins in the NO/cGMP signaling pathway, down-regulation of the matrix proteins osteopontin and thrombospondin-1 to limit smooth muscle cell migration and phenotype. Regulates vasodilator-stimulated phosphoprotein (VASP) functions in platelets and smooth muscle."	""	"FALSE"
"13078-3_3"	""	"CETN2"	"Centrin-2"	"X"	"151995517"	"151999321"	"CETN2"	"ENSG00000147400"	"P41208"	""	""	""	""	""	""	""	"Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110."	""	"FALSE"
"13083-18_3"	""	"SYVC"	"Valine--tRNA ligase"	"6"	"31745295"	"31763730"	"VARS"	"ENSG00000204394"	"P26640"	""	""	""	""	""	""	""	"ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)."	""	"FALSE"
"13090-17_3"	""	"S100A6"	"Protein S100-A6"	"1"	"153507075"	"153508720"	"S100A6"	"ENSG00000197956"	"P06703"	""	""	""	""	""	""	""	"May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative."	""	"FALSE"
"13093-6_3"	""	"SECTM1"	"Secreted and transmembrane protein 1"	"17"	"80278900"	"80291950"	"SECTM1"	"ENSG00000141574"	"Q8WVN6"	""	""	""	""	""	""	""	"May be involved in thymocyte signaling."	""	"FALSE"
"13094-75_3"	""	"RSPO3"	"R-spondin-3"	"6"	"127439749"	"127518910"	"RSPO3"	"ENSG00000146374"	"Q9BXY4"	""	""	""	""	""	""	""	"Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway (PubMed:21727895, PubMed:21909076, PubMed:22615920). Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (By similarity)."	""	"FALSE"
"13098-93_3"	""	"VEGF-D"	"Vascular endothelial growth factor D"	"X"	"15363713"	"15402498"	"FIGF"	"ENSG00000165197"	"O43915"	""	""	""	""	""	""	""	"Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors."	""	"FALSE"
"13102-1_3"	""	"FAM3D"	"Protein FAM3D"	"3"	"58619673"	"58652575"	"FAM3D"	"ENSG00000198643"	"Q96BQ1"	""	""	""	""	""	""	""	"Secreted"	""	"FALSE"
"13105-7_3"	""	"SNP25"	"Synaptosomal-associated protein 25"	"20"	"10199478"	"10288066"	"SNAP25"	"ENSG00000132639"	"P60880"	""	""	""	""	""	""	""	"t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells."	""	"FALSE"
"13112-179_3"	""	"FSTL1"	"Follistatin-related protein 1"	"3"	"120111140"	"120170100"	"FSTL1"	"ENSG00000163430"	"Q12841"	""	""	""	""	""	""	""	"May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin (By similarity)."	""	"FALSE"
"13116-25_3"	""	"CD177"	"CD177 antigen"	"19"	"43857811"	"43867324"	"CD177"	"ENSG00000204936"	"Q8N6Q3"	""	""	""	""	""	""	""	"In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production (PubMed:21193407). In addition, by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration (PubMed:28807980). Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro (PubMed:17580308). However, appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo (PubMed:23461681). Acts as a receptor for the mature form of protease PRTN3 allowing its display at the cell surface of neutrophils (PubMed:17244676, PubMed:18462208). By displaying PRTN3 at the neutrophil cell surface, may play a role in enhancing endothelial cell junctional integrity and thus vascular integrity during neutrophil diapedesis (PubMed:23202369)."	""	"FALSE"
"13117-232_3"	""	"CHKB"	"Choline/ethanolamine kinase"	"22"	"51017378"	"51039884"	"CHKB"	"ENSG00000100288"	"Q9Y259"	""	""	""	""	""	""	""	"Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis."	""	"FALSE"
"13118-5_3"	""	"SMOC1"	"SPARC-related modular calcium-binding protein 1"	"14"	"70320848"	"70499083"	"SMOC1"	"ENSG00000198732"	"Q9H4F8"	""	""	""	""	""	""	""	"Plays essential roles in both eye and limb development. Probable regulator of osteoblast differentiation."	""	"FALSE"
"13119-26_3"	""	"protein Z inhibitor"	"Protein Z-dependent protease inhibitor"	"14"	"94746792"	"94759608"	"SERPINA10"	"ENSG00000140093"	"Q9UK55"	""	""	""	""	""	""	""	"Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors."	""	"FALSE"
"13122-19_3"	""	"FLRT2"	"Leucine-rich repeat transmembrane protein FLRT2"	"14"	"85996488"	"86120770"	"FLRT2"	"ENSG00000185070"	"O43155"	""	""	""	""	""	""	""	"Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis."	""	"FALSE"
"13123-3_3"	""	"FLRT3"	"Leucine-rich repeat transmembrane protein FLRT3"	"20"	"14303634"	"14318262"	"FLRT3"	"ENSG00000125848"	"Q9NZU0"	""	""	""	""	""	""	""	"Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development in the retina (By similarity). Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells (PubMed:26235030). Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5B, and possibly also other UNC-5 family members (By similarity). Promotes neurite outgrowth (in vitro) (PubMed:14706654). Mediates cell-cell contacts that promote an increase both in neurite number and in neurite length. Plays a role in the regulation of the density of glutamaergic synapses. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal morphogenesis during embryonic development, but not for normal embryonic patterning. Required for normal ventral closure, headfold fusion and definitive endoderm migration during embryonic development. Required for the formation of a normal basement membrane and the maintenance of a normal anterior visceral endoderm during embryonic development (By similarity)."	""	"FALSE"
"13124-20_3"	""	"ISLR2"	"Immunoglobulin superfamily containing leucine-rich repeat protein 2"	"15"	"74392652"	"74430881"	"ISLR2"	"ENSG00000167178"	"Q6UXK2"	""	""	""	""	""	""	""	"Required for axon extension during neural development."	""	"FALSE"
"13125-45_3"	""	"Vitronectin"	"Vitronectin"	"17"	"26694297"	"26700110"	"VTN"	"ENSG00000109072"	"P04004"	""	""	""	""	""	""	""	"Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway."	""	"FALSE"
"13126-52_3"	""	"DSC2"	"Desmocollin-2"	"18"	"28638806"	"28682378"	"DSC2"	"ENSG00000134755"	"Q02487"	""	""	""	""	""	""	""	"Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms."	""	"FALSE"
"13130-150_3"	""	"HXK2"	"Hexokinase-2"	"2"	"75061108"	"75120486"	"HK2"	"ENSG00000159399"	"P52789"	""	""	""	""	""	""	""	"ATP + D-hexose = ADP + D-hexose 6-phosphate."	""	"FALSE"
"13131-5_3"	""	"HXK1"	"Hexokinase-1"	"10"	"71029740"	"71161638"	"HK1"	"ENSG00000156515"	"P19367"	""	""	""	""	""	""	""	"ATP + D-hexose = ADP + D-hexose 6-phosphate."	""	"FALSE"
"13132-14_3"	""	"SEM5A"	"Semaphorin-5A"	"5"	"9035138"	"9546187"	"SEMA5A"	"ENSG00000112902"	"Q13591"	""	""	""	""	""	""	""	"Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis."	""	"FALSE"
"13378-80_3"	""	"YD286"	"Glutaredoxin-like protein C5orf63"	"5"	"126378250"	"126409184"	"C5orf63"	"ENSG00000164241"	"A6NC05"	""	""	""	""	""	""	""	"alternative splicing"	""	"FALSE"
"13381-49_3"	""	"B4GT1"	"Beta-1,4-galactosyltransferase 1"	"9"	"33104080"	"33167354"	"B4GALT1"	"ENSG00000086062"	"P15291"	""	""	""	""	""	""	""	"The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids."	""	"FALSE"
"13388-57_3"	""	"NEC1"	"Neuroendocrine convertase 1"	"5"	"95726119"	"95769847"	"PCSK1"	"ENSG00000175426"	"P29120"	""	""	""	""	""	""	""	"Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP."	""	"FALSE"
"13389-8_3"	""	"GALA"	"Galanin peptides"	"11"	"68451247"	"68458643"	"GAL"	"ENSG00000069482"	"P22466"	""	""	""	""	""	""	""	"Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion."	""	"FALSE"
"13399-33_3"	""	"RELL1"	"RELT-like protein 1"	"4"	"37592422"	"37687998"	"RELL1"	"ENSG00000181826"	"Q8IUW5"	""	""	""	""	""	""	""	"Interacts with RELT, RELL2 and OXSR1."	""	"FALSE"
"13405-61_3"	""	"ISK2"	"Serine protease inhibitor Kazal-type 2"	"4"	"57676026"	"57687908"	"SPINK2"	"ENSG00000128040"	"P20155"	""	""	""	""	""	""	""	"Strong inhibitor of acrosin in male and/or female genital tract. Also inhibits trypsin."	""	"FALSE"
"13406-161_3"	""	"CLM6"	"CMRF35-like molecule 6"	"17"	"72537247"	"72542282"	"CD300C"	"ENSG00000167850"	"Q08708"	""	""	""	""	""	""	""	"Cell membrane"	""	"FALSE"
"13408-23_3"	""	"WFKN2"	"WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2"	"17"	"48912011"	"48919709"	"WFIKKN2"	"ENSG00000173714"	"Q8TEU8"	""	""	""	""	""	""	""	"Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity. Inhibits the biological activity of mature myostatin, but not activin (By similarity)."	""	"FALSE"
"13409-9_3"	""	"NSG2"	"Neuron-specific protein family member 2"	"5"	"173472607"	"173670504"	"NSG2"	"ENSG00000170091"	"Q9Y328"	""	""	""	""	""	""	""	"Membrane"	""	"FALSE"
"13416-8_3"	""	"T132D"	"Transmembrane protein 132D"	"12"	"129556270"	"130388211"	"TMEM132D"	"ENSG00000151952"	"Q14C87"	""	""	""	""	""	""	""	"May serve as a cell-surface marker for oligodendrocyte differentiation."	""	"FALSE"
"13423-94_3"	""	"CJ058"	"Redox-regulatory protein FAM213A"	"10"	"82167585"	"82196871"	"FAM213A"	"ENSG00000122378"	"Q9BRX8"	""	""	""	""	""	""	""	"Involved in redox regulation of the cell (PubMed:26438880, PubMed:19951071). Acts as an antioxidant (PubMed:19951071, PubMed:26438880). Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation (PubMed:19951071). May affect bone resorption and help to maintain bone mass (PubMed:19951071). Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway (PubMed:26438880)."	""	"FALSE"
"13424-51_3"	""	"AIF"	"Apoptosis-inducing factor 1, mitochondrial"	"X"	"129263337"	"129299861"	"AIFM1"	"ENSG00000156709"	"O95831"	""	""	""	""	""	""	""	"Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner."	""	"FALSE"
"13450-49_3"	""	"UBP8"	"Ubiquitin carboxyl-terminal hydrolase 8"	"15"	"50716577"	"50806616"	"USP8"	"ENSG00000138592"	"P40818"	""	""	""	""	""	""	""	"Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1."	""	"FALSE"
"13453-2_3"	""	"RM33"	"39S ribosomal protein L33, mitochondrial"	"2"	"27994584"	"28210954"	"MRPL33"	"ENSG00000243147"	"O75394"	""	""	""	""	""	""	""	"Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins."	""	"FALSE"
"13455-10_3"	""	"DB119"	"Beta-defensin 119"	"20"	"29964967"	"29978406"	"DEFB119"	"ENSG00000180483"	"Q8N690"	""	""	""	""	""	""	""	"Has antibacterial activity."	""	"FALSE"
"13464-8_3"	""	"NRAC"	"Nutritionally-regulated adipose and cardiac enriched protein homolog"	"14"	"105046021"	"105056852"	"NRAC"	"ENSG00000184601"	"Q8N912"	""	""	""	""	""	""	""	"EBI-12051377"	""	"FALSE"
"13465-5_3"	""	"CCP1"	"Calcipressin-1"	"21"	"35885440"	"35987441"	"RCAN1"	"ENSG00000159200"	"P53805"	""	""	""	""	""	""	""	"Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A (PubMed:12809556). Could play a role during central nervous system development (By similarity)."	""	"FALSE"
"13472-35_3"	""	"HDHD2"	"Haloacid dehalogenase-like hydrolase domain-containing protein 2"	"18"	"44633774"	"44676891"	"HDHD2"	"ENSG00000167220"	"Q9H0R4"	""	""	""	""	""	""	""	"Mg(2+)"	""	"FALSE"
"13475-10_3"	""	"UB2D4"	"Ubiquitin-conjugating enzyme E2 D4"	"7"	"43966037"	"43995735"	"UBE2D4"	"ENSG00000078967"	"Q9Y2X8"	""	""	""	""	""	""	""	"Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11' and 'Lys-48'-linked polyubiquitination."	""	"FALSE"
"13476-16_3"	""	"KIN17"	"DNA/RNA-binding protein KIN17"	"10"	"7792925"	"7829944"	"KIN"	"ENSG00000151657"	"O60870"	""	""	""	""	""	""	""	"Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity). Binds via its C-terminal domain to RNA in vitro."	""	"FALSE"
"13485-20_3"	""	"TM87B"	"Transmembrane protein 87B"	"2"	"112812800"	"112876895"	"TMEM87B"	"ENSG00000153214"	"Q96K49"	""	""	""	""	""	""	""	"May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN)."	""	"FALSE"
"13487-24_3"	""	"UN93B"	"Protein unc-93 homolog B1"	"11"	"67758575"	"67772452"	"UNC93B1"	"ENSG00000110057"	"Q9H1C4"	""	""	""	""	""	""	""	"Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal."	""	"FALSE"
"13488-3_3"	""	"ARFP1"	"Arfaptin-1"	"4"	"153608879"	"153839615"	"ARFIP1"	"ENSG00000164144"	"P53367"	""	""	""	""	""	""	""	"Putative target protein of ADP-ribosylation factor."	""	"FALSE"
"13490-1_3"	""	"MPP6"	"MAGUK p55 subfamily member 6"	"7"	"24612887"	"24733812"	"MPP6"	"ENSG00000105926"	"Q9NZW5"	""	""	""	""	""	""	""	"Interacts with CADM1 (By similarity). Interacts with the LIN7 proteins."	""	"FALSE"
"13491-40_3"	""	"PDE6D"	"Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta"	"2"	"232597135"	"232650982"	"PDE6D"	"ENSG00000156973"	"O43924"	""	""	""	""	""	""	""	"Promotes the release of prenylated target proteins from cellular membranes (PubMed:9712853). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (PubMed:22002721, PubMed:23698361). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (PubMed:24166846). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate (By similarity)."	""	"FALSE"
"13497-34_3"	""	"EIF3J"	"Eukaryotic translation initiation factor 3 subunit J"	"15"	"44829255"	"44855227"	"EIF3J"	"ENSG00000104131"	"O75822"	""	""	""	""	""	""	""	"Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773)."	""	"FALSE"
"13499-30_3"	""	"Coagulation Factor VIII"	"Coagulation Factor VIII"	"X"	"154064063"	"154255215"	"F8"	"ENSG00000185010"	"P00451"	""	""	""	""	""	""	""	"Factor VIII, along with calcium and phospholipid, acts as a cofactor for F9/factor IXa when it converts F10/factor X to the activated form, factor Xa."	""	"FALSE"
"13500-9_3"	""	"TEX29"	"Testis-expressed sequence 29 protein"	"13"	"111968531"	"111996596"	"TEX29"	"ENSG00000153495"	"Q8N6K0"	""	""	""	""	""	""	""	"Membrane"	""	"FALSE"
"13501-10_3"	""	"S35G2"	"Solute carrier family 35 member G2"	"3"	"136537489"	"136574734"	"SLC35G2"	"ENSG00000168917"	"Q8TBE7"	""	""	""	""	""	""	""	"May play a role in cell proliferation."	""	"FALSE"
"13510-7_3"	""	"AT2A3"	"Sarcoplasmic/endoplasmic reticulum calcium ATPase 3"	"17"	"3827164"	"3867758"	"ATP2A3"	"ENSG00000074370"	"Q93084"	""	""	""	""	""	""	""	"This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction."	""	"FALSE"
"13514-121_3"	""	"Rab-1C"	"Ras-related protein Rab-35"	"12"	"120532899"	"120555306"	"RAB35"	"ENSG00000111737"	"Q15286"	""	""	""	""	""	""	""	"The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge. May indirectly regulate neurite outgrowth. Together with TBC1D13 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes."	""	"FALSE"
"13515-8_3"	""	"RPR1A"	"Regulation of nuclear pre-mRNA domain-containing protein 1A"	"18"	"33564350"	"33647539"	"RPRD1A"	"ENSG00000141425"	"Q96P16"	""	""	""	""	""	""	""	"Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle."	""	"FALSE"
"13516-46_3"	""	"TMM85"	"ER membrane protein complex subunit 4"	"15"	"34517200"	"34522357"	"EMC4"	"ENSG00000128463"	"Q5J8M3"	""	""	""	""	""	""	""	"May mediate anti-apoptotic activity."	""	"FALSE"
"13518-5_3"	""	"ASAP2"	"Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2"	"2"	"9346894"	"9545812"	"ASAP2"	"ENSG00000151693"	"O43150"	""	""	""	""	""	""	""	"Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration."	""	"FALSE"
"13529-39_3"	""	"NP1L2"	"Nucleosome assembly protein 1-like 2"	"X"	"72432135"	"72434684"	"NAP1L2"	"ENSG00000186462"	"Q9ULW6"	""	""	""	""	""	""	""	"Acidic protein which may be involved in interactions with other proteins or DNA."	""	"FALSE"
"13541-1_3"	""	"MYCT1"	"Myc target protein 1"	"6"	"153019030"	"153045702"	"MYCT1"	"ENSG00000120279"	"Q8N699"	""	""	""	""	""	""	""	"May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation (By similarity)."	""	"FALSE"
"13543-7_3"	""	"LTB4DH"	"Prostaglandin reductase 1"	"9"	"114312002"	"114362135"	"PTGR1"	"ENSG00000106853"	"Q14914"	""	""	""	""	""	""	""	"Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha (By similarity). Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4."	""	"FALSE"
"13545-97_3"	""	"EIF1A"	"Probable RNA-binding protein EIF1AD"	"11"	"65764016"	"65769647"	"EIF1AD"	"ENSG00000175376"	"Q8N9N8"	""	""	""	""	""	""	""	"Plays a role into cellular response to oxidative stress. Decreases cell proliferation."	""	"FALSE"
"13552-7_3"	""	"SWP70"	"Switch-associated protein 70"	"11"	"9685624"	"9774538"	"SWAP70"	"ENSG00000133789"	"Q9UH65"	""	""	""	""	""	""	""	"Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity)."	""	"FALSE"
"13554-78_3"	""	"REPI1"	"Replication initiator 1"	"7"	"150065278"	"150071133"	"REPIN1"	"ENSG00000214022"	"Q9BWE0"	""	""	""	""	""	""	""	"Sequence-specific double-stranded DNA-binding protein required for initiation of chromosomal DNA replication. Binds on 5'-ATT-3' reiterated sequences downstream of the origin of bidirectional replication (OBR) and a second, homologous ATT sequence of opposite orientation situated within the OBR zone. Facilitates DNA bending."	""	"FALSE"
"13563-259_3"	""	"ACBD7"	"Acyl-CoA-binding domain-containing protein 7"	"10"	"15119522"	"15130775"	"ACBD7"	"ENSG00000176244"	"Q8N6N7"	""	""	""	""	""	""	""	"Binds medium- and long-chain acyl-CoA esters."	""	"FALSE"
"13566-2_3"	""	"SSU72"	"RNA polymerase II subunit A C-terminal domain phosphatase SSU72"	"1"	"1477053"	"1510249"	"SSU72"	"ENSG00000160075"	"Q9NP77"	""	""	""	""	""	""	""	"Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK."	""	"FALSE"
"13570-43_3"	""	"VIGLN"	"Vigilin"	"2"	"242166679"	"242256476"	"HDLBP"	"ENSG00000115677"	"Q00341"	""	""	""	""	""	""	""	"Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol."	""	"FALSE"
"13575-40_3"	""	"DVL2"	"Segment polarity protein dishevelled homolog DVL-2"	"17"	"7128660"	"7137864"	"DVL2"	"ENSG00000004975"	"O14641"	""	""	""	""	""	""	""	"Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling."	""	"FALSE"
"13580-2_3"	""	"Sperm-associated antigen 2"	"UDP-N-acetylhexosamine pyrophosphorylase"	"1"	"162531296"	"162569632"	"UAP1"	"ENSG00000117143"	"Q16222"	""	""	""	""	""	""	""	"Converts UTP and GlcNAc-1-P into UDP-GlcNAc, and UTP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P."	""	"FALSE"
"13583-19_3"	""	"Apaf-1"	"Apoptotic protease-activating factor 1"	"12"	"99038919"	"99129211"	"APAF1"	"ENSG00000120868"	"O14727"	""	""	""	""	""	""	""	"Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis."	""	"FALSE"
"13587-10_3"	""	"RGAP1"	"Rac GTPase-activating protein 1"	"12"	"50370706"	"50426919"	"RACGAP1"	"ENSG00000161800"	"Q9H0H5"	""	""	""	""	""	""	""	"Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells."	""	"FALSE"
"13594-158_3"	""	"GGA1"	"ADP-ribosylation factor-binding protein GGA1"	"22"	"38004482"	"38029571"	"GGA1"	"ENSG00000100083"	"Q9UJY5"	""	""	""	""	""	""	""	"Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif."	""	"FALSE"
"13599-15_3"	""	"RABEK"	"Rab9 effector protein with kelch motifs"	"9"	"127962821"	"127996437"	"RABEPK"	"ENSG00000136933"	"Q7Z6M1"	""	""	""	""	""	""	""	"Rab9 effector required for endosome to trans-Golgi network (TGN) transport."	""	"FALSE"
"13602-6_3"	""	"NH2L1"	"NHP2-like protein 1"	"22"	"42069934"	"42086508"	"NHP2L1"	"ENSG00000100138"	"P55769"	""	""	""	""	""	""	""	"Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28781166). Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly (PubMed:10545122, PubMed:17412961). The protein undergoes a conformational change upon RNA-binding (PubMed:17412961)."	""	"FALSE"
"13603-7_3"	""	"RFESD"	"Rieske domain-containing protein"	"5"	"94982458"	"95020477"	"RFESD"	"ENSG00000175449"	"Q8TAC1"	""	""	""	""	""	""	""	"[2Fe-2S] cluster"	""	"FALSE"
"13604-27_3"	""	"NEUL1"	"E3 ubiquitin-protein ligase NEURL1"	"10"	"105253736"	"105352309"	"NEURL1"	"ENSG00000107954"	"O76050"	""	""	""	""	""	""	""	"Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway."	""	"FALSE"
"13605-16_3"	""	"ANX10"	"Annexin A10"	"4"	"169013666"	"169108841"	"ANXA10"	"ENSG00000109511"	"Q9UJ72"	""	""	""	""	""	""	""	"EBI-8648654"	""	"FALSE"
"13609-11_3"	""	"GTF2I"	"General transcription factor II-I"	"7"	"74071994"	"74175022"	"GTF2I"	"ENSG00000263001"	"P78347"	""	""	""	""	""	""	""	"Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation."	""	"FALSE"
"13610-9_3"	""	"MAGE-10"	"Melanoma-associated antigen 10"	"X"	"151301782"	"151307050"	"MAGEA10"	"ENSG00000124260"	"P43363"	""	""	""	""	""	""	""	"Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression."	""	"FALSE"
"13614-6_3"	""	"CREB-binding protein"	"CREB-binding protein"	"16"	"3775055"	"3930727"	"CREBBP"	"ENSG00000005339"	"Q92793"	""	""	""	""	""	""	""	"Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902)."	""	"FALSE"
"13618-15_3"	""	"MD1L1"	"Mitotic spindle assembly checkpoint protein MAD1"	"7"	"1855429"	"2272878"	"MAD1L1"	"ENSG00000002822"	"Q9Y6D9"	""	""	""	""	""	""	""	"Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding."	""	"FALSE"
"13623-4_3"	""	"MLL2"	"Histone-lysine N-methyltransferase 2D"	"12"	"49412758"	"49453557"	"KMT2D"	"ENSG00000167548"	"O14686"	""	""	""	""	""	""	""	"Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription."	""	"FALSE"
"13624-17_3"	""	"NADK"	"NAD kinase"	"1"	"1682671"	"1711896"	"NADK"	"ENSG00000008130"	"O95544"	""	""	""	""	""	""	""	"ATP + NAD(+) = ADP + NADP(+)."	""	"FALSE"
"13628-58_3"	""	"GRB14"	"Growth factor receptor-bound protein 14"	"2"	"165349322"	"165478358"	"GRB14"	"ENSG00000115290"	"Q14449"	""	""	""	""	""	""	""	"Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal."	""	"FALSE"
"13634-209_3"	""	"PIR"	"Pirin"	"X"	"15402921"	"15511687"	"PIR"	"ENSG00000087842"	"O00625"	""	""	""	""	""	""	""	"Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro)."	""	"FALSE"
"13642-90_3"	""	"CIG49"	"Interferon-induced protein with tetratricopeptide repeats 3"	"10"	"91087651"	"91100728"	"IFIT3"	"ENSG00000119917"	"O14879"	""	""	""	""	""	""	""	"IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2."	""	"FALSE"
"13645-14_3"	""	"PRP16"	"Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16"	"16"	"72127461"	"72146811"	"DHX38"	"ENSG00000140829"	"Q92620"	""	""	""	""	""	""	""	"Probable ATP-binding RNA helicase involved in pre-mRNA splicing."	""	"FALSE"
"13650-11_3"	""	"KCIP1"	"Kv channel-interacting protein 1"	"5"	"169780491"	"170163636"	"KCNIP1"	"ENSG00000182132"	"Q9NZI2"	""	""	""	""	""	""	""	"Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Regulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Increases the presence of KCND2 at the cell surface."	""	"FALSE"
"13652-2_3"	""	"TM1L1"	"TOM1-like protein 1"	"17"	"52976748"	"53039317"	"TOM1L1"	"ENSG00000141198"	"O75674"	""	""	""	""	""	""	""	"Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions (By similarity)."	""	"FALSE"
"13655-34_3"	""	"Nucleolin"	"Nucleolin"	"2"	"232318242"	"232348352"	"NCL"	"ENSG00000115053"	"P19338"	""	""	""	""	""	""	""	"Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats."	""	"FALSE"
"13657-2_3"	""	"PNKP"	"Bifunctional polynucleotide phosphatase/kinase"	"19"	"50364461"	"50381608"	"PNKP"	"ENSG00000039650"	"Q96T60"	""	""	""	""	""	""	""	"Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone."	""	"FALSE"
"13665-35_3"	""	"PP2A, subunit B"	"Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha"	"3"	"135684515"	"135866733"	"PPP2R3A"	"ENSG00000073711"	"Q06190"	""	""	""	""	""	""	""	"The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment."	""	"FALSE"
"13666-222_3"	""	"Carbonic Anhydrase X"	"Carbonic anhydrase-related protein 10"	"17"	"49707674"	"50237377"	"CA10"	"ENSG00000154975"	"Q9NS85"	""	""	""	""	""	""	""	"Does not have a catalytic activity."	""	"FALSE"
"13672-3_3"	""	"HSP76"	"Heat shock 70 kDa protein 6"	"1"	"161494330"	"161496700"	"HSPA6"	"ENSG00000173110"	"P17066"	""	""	""	""	""	""	""	"Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365)."	""	"FALSE"
"13686-2_3"	""	"IL-5 Ra"	"Interleukin-5 receptor subunit alpha"	"3"	"3108010"	"3168297"	"IL5RA"	"ENSG00000091181"	"Q01344"	""	""	""	""	""	""	""	"This is the receptor for interleukin-5. The alpha chain binds to IL5."	""	"FALSE"
"13690-26_3"	""	"BGN"	"Biglycan"	"X"	"152760397"	"152775012"	"BGN"	"ENSG00000182492"	"P21810"	""	""	""	""	""	""	""	"May be involved in collagen fiber assembly."	""	"FALSE"
"13691-10_3"	""	"SC5A8"	"Sodium-coupled monocarboxylate transporter 1"	"12"	"101549271"	"101604185"	"SLC5A8"	"ENSG00000256870"	"Q8N695"	""	""	""	""	""	""	""	"Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons."	""	"FALSE"
"13692-154_3"	""	"WISP-1"	"WNT1-inducible-signaling pathway protein 1"	"8"	"134203282"	"134242587"	"WISP1"	"ENSG00000104415"	"O95388"	""	""	""	""	""	""	""	"Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan."	""	"FALSE"
"13700-10_3"	""	"annexin II"	"Annexin A2"	"15"	"60639333"	"60695082"	"ANXA2"	"ENSG00000182718"	"P07355"	""	""	""	""	""	""	""	"Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:24808179, PubMed:22848640)."	""	"FALSE"
"13708-56_3"	""	"kallikrein 8"	"Kallikrein-8"	"19"	"51499263"	"51505967"	"KLK8"	"ENSG00000129455"	"O60259"	""	""	""	""	""	""	""	"Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury."	""	"FALSE"
"13719-19_3"	""	"PAK4"	"Serine/threonine-protein kinase PAK 4"	"19"	"39616410"	"39673456"	"PAK4"	"ENSG00000130669"	"O96013"	""	""	""	""	""	""	""	"Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN."	""	"FALSE"
"13720-95_3"	""	"Proteinase-3"	"Myeloblastin"	"19"	"840960"	"848175"	"PRTN3"	"ENSG00000196415"	"P24158"	""	""	""	""	""	""	""	"Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369). May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279)."	""	"FALSE"
"13725-3_3"	""	"FGF-16"	"Fibroblast growth factor 16"	"X"	"76709648"	"76712769"	"FGF16"	"ENSG00000196468"	"O43320"	""	""	""	""	""	""	""	"Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development."	""	"FALSE"
"13732-79_3"	""	"Cardiotrophin-1"	"Cardiotrophin-1"	"16"	"30907928"	"30914881"	"CTF1"	"ENSG00000150281"	"Q16619"	""	""	""	""	""	""	""	"Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor."	""	"FALSE"
"13735-1_3"	""	"RPGP1"	"Rap1 GTPase-activating protein 1"	"1"	"21922708"	"21995856"	"RAP1GAP"	"ENSG00000076864"	"P47736"	""	""	""	""	""	""	""	"GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state."	""	"FALSE"
"13740-51_3"	""	"sFRP-3"	"Secreted frizzled-related protein 3"	"2"	"183698002"	"183731890"	"FRZB"	"ENSG00000162998"	"Q92765"	""	""	""	""	""	""	""	"Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development."	""	"FALSE"
"13744-37_3"	""	"IL-3 Ra"	"Interleukin-3 receptor subunit alpha"	"X"	"1455509"	"1501582"	"IL3RA"	"ENSG00000185291"	"P26951"	""	""	""	""	""	""	""	"This is a receptor for interleukin-3."	""	"FALSE"
"13926-1_3"	""	"RMI1"	"RecQ-mediated genome instability protein 1"	"9"	"86595626"	"86618989"	"RMI1"	"ENSG00000178966"	"Q9H9A7"	""	""	""	""	""	""	""	"Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability."	""	"FALSE"
"13940-19_3"	""	"IP16"	"Gamma-interferon-inducible protein 16"	"1"	"158969758"	"159024945"	"IFI16"	"ENSG00000163565"	"Q16666"	""	""	""	""	""	""	""	"Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer."	""	"FALSE"
"13941-82_3"	""	"SYFM"	"Phenylalanine--tRNA ligase, mitochondrial"	"6"	"5261277"	"5771813"	"FARS2"	"ENSG00000145982"	"O95363"	""	""	""	""	""	""	""	"Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation. To a lesser extent, also catalyzes direct attachment of m-Tyr (an oxidized version of Phe) to tRNA(Phe), thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins."	""	"FALSE"
"13947-371_3"	""	"NUD12"	"Peroxisomal NADH pyrophosphatase NUDT12"	"5"	"102884556"	"102898494"	"NUDT12"	"ENSG00000112874"	"Q9BQG2"	""	""	""	""	""	""	""	"Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle."	""	"FALSE"
"13948-50_3"	""	"GABR2"	"Gamma-aminobutyric acid type B receptor subunit 2"	"9"	"101050391"	"101471479"	"GABBR2"	"ENSG00000136928"	"O75899"	""	""	""	""	""	""	""	"Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:9872316, PubMed:9872744, PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644, PubMed:10773016, PubMed:24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644, PubMed:9872744, PubMed:10906333, PubMed:10773016). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:9872744, PubMed:22660477). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:9872316, PubMed:10075644, PubMed:9872744, PubMed:22660477). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable)."	""	"FALSE"
"13954-9_3"	""	"GNA1"	"Glucosamine 6-phosphate N-acetyltransferase"	"14"	"53241912"	"53258386"	"GNPNAT1"	"ENSG00000100522"	"Q96EK6"	""	""	""	""	""	""	""	"Acetyl-CoA + D-glucosamine 6-phosphate = CoA + N-acetyl-D-glucosamine 6-phosphate."	""	"FALSE"
"13963-7_3"	""	"tollip"	"Toll-interacting protein"	"11"	"1295601"	"1330884"	"TOLLIP"	"ENSG00000078902"	"Q9H0E2"	""	""	""	""	""	""	""	"Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856). Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851)."	""	"FALSE"
"13967-14_3"	""	"Thioredoxin reductase 1"	"Thioredoxin reductase 1, cytoplasmic"	"12"	"104609557"	"104744083"	"TXNRD1"	"ENSG00000198431"	"Q16881"	""	""	""	""	""	""	""	"Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid."	""	"FALSE"
"13973-62_3"	""	"TTL"	"Tubulin--tyrosine ligase"	"2"	"113239731"	"113299316"	"TTL"	"ENSG00000114999"	"Q8NG68"	""	""	""	""	""	""	""	"Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin."	""	"FALSE"
"13976-9_3"	""	"ARHG1"	"Rho guanine nucleotide exchange factor 1"	"19"	"42387228"	"42434302"	"ARHGEF1"	"ENSG00000076928"	"Q92888"	""	""	""	""	""	""	""	"Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation."	""	"FALSE"
"13982-33_3"	""	"RGS18"	"Regulator of G-protein signaling 18"	"1"	"192127587"	"192154945"	"RGS18"	"ENSG00000150681"	"Q9NS28"	""	""	""	""	""	""	""	"Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha."	""	"FALSE"
"13988-67_3"	""	"NMRL1"	"NmrA-like family domain-containing protein 1"	"16"	"4511681"	"4545764"	"NMRAL1"	"ENSG00000153406"	"Q9HBL8"	""	""	""	""	""	""	""	"Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer."	""	"FALSE"
"13992-12_3"	""	"NSF"	"Vesicle-fusing ATPase"	"17"	"44668035"	"44834830"	"NSF"	"ENSG00000073969"	"P46459"	""	""	""	""	""	""	""	"Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity)."	""	"FALSE"
"14002-18_3"	""	"DOCK9"	"Dedicator of cytokinesis protein 9"	"13"	"99445741"	"99738879"	"DOCK9"	"ENSG00000088387"	"Q9BZ29"	""	""	""	""	""	""	""	"Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation."	""	"FALSE"
"14006-36_3"	""	"GNMT"	"Glycine N-methyltransferase"	"6"	"42928496"	"42931618"	"GNMT"	"ENSG00000124713"	"Q14749"	""	""	""	""	""	""	""	"Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine."	""	"FALSE"
"14011-17_3"	""	"S100A11"	"Protein S100-A11"	"1"	"152004982"	"152020383"	"S100A11"	"ENSG00000163191"	"P31949"	""	""	""	""	""	""	""	"Facilitates the differentiation and the cornification of keratinocytes."	""	"FALSE"
"14021-81_3"	""	"MED4"	"Mediator of RNA polymerase II transcription subunit 4"	"13"	"48627459"	"48669267"	"MED4"	"ENSG00000136146"	"Q9NPJ6"	""	""	""	""	""	""	""	"Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors."	""	"FALSE"
"14023-84_3"	""	"BSP"	"Bone sialoprotein 2"	"4"	"88720733"	"88733587"	"IBSP"	"ENSG00000029559"	"P21815"	""	""	""	""	""	""	""	"Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment."	""	"FALSE"
"14028-22_3"	""	"P3C2A"	"Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha"	"11"	"17099277"	"17229530"	"PIK3C2A"	"ENSG00000011405"	"O00443"	""	""	""	""	""	""	""	"Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function."	""	"FALSE"
"14029-42_3"	""	"CSN2"	"COP9 signalosome complex subunit 2"	"15"	"49398265"	"49447858"	"COPS2"	"ENSG00000166200"	"P61201"	""	""	""	""	""	""	""	"Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1."	""	"FALSE"
"14031-18_3"	""	"FGF7"	"Fibroblast growth factor 7"	"15"	"49715293"	"49780972"	"FGF7"	"ENSG00000140285"	"P21781"	""	""	""	""	""	""	""	"Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation."	""	"FALSE"
"14032-2_3"	""	"VEGF121"	"Vascular endothelial growth factor A, isoform 121"	"6"	"43737921"	"43754224"	"VEGFA"	"ENSG00000112715"	"P15692"	""	""	""	""	""	""	""	"Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity)."	""	"FALSE"
"14041-13_3"	""	"Granzyme B"	"Granzyme B"	"14"	"25100160"	"25103473"	"GZMB"	"ENSG00000100453"	"P10144"	""	""	""	""	""	""	""	"This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis."	""	"FALSE"
"14045-12_3"	""	"NCOA2"	"Nuclear receptor coactivator 2"	"8"	"71021997"	"71316040"	"NCOA2"	"ENSG00000140396"	"Q15596"	""	""	""	""	""	""	""	"Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer (By similarity)."	""	"FALSE"
"14048-7_3"	""	"IL-1 R AcP"	"Interleukin-1 Receptor accessory protein"	"3"	"190231840"	"190377539"	"IL1RAP"	"ENSG00000196083"	"Q9NPH3"	""	""	""	""	""	""	""	"Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable)."	""	"FALSE"
"14054-17_3"	""	"IL-15 Ra"	"Interleukin-15 receptor subunit alpha"	"10"	"5979532"	"6020150"	"IL15RA"	"ENSG00000134470"	"Q13261"	""	""	""	""	""	""	""	"High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves SYK."	""	"FALSE"
"14068-29_3"	""	"TECK"	"C-C motif chemokine 25"	"19"	"8117651"	"8127534"	"CCL25"	"ENSG00000131142"	"O15444"	""	""	""	""	""	""	""	"Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4."	""	"FALSE"
"14070-56_3"	""	"ITSN1"	"Intersectin-1"	"21"	"35014706"	"35272165"	"ITSN1"	"ENSG00000205726"	"Q15811"	""	""	""	""	""	""	""	"Acts as guanine nucleotide exchange factor (GEF) specific for the CDC42 GTPase (By similarity). Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1."	""	"FALSE"
"14078-69_3"	""	"Lymphotactin"	"Lymphotactin"	"1"	"168545711"	"168551315"	"XCL1"	"ENSG00000143184"	"P47992"	""	""	""	""	""	""	""	"Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment."	""	"FALSE"
"14079-14_3"	""	"IL-18 Ra"	"Interleukin-18 receptor 1"	"2"	"102927989"	"103015235"	"IL18R1"	"ENSG00000115604"	"Q13478"	""	""	""	""	""	""	""	"Within the IL18 receptor complex, responsible for the binding of the proinflammatory cytokine IL18, but not IL1A nor IL1B (PubMed:8626725, PubMed:14528293, PubMed:25261253, PubMed:25500532). Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850). Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity)."	""	"FALSE"
"14082-56_3"	""	"TLN2"	"Talin-2"	"15"	"62682725"	"63136830"	"TLN2"	"ENSG00000171914"	"Q9Y4G6"	""	""	""	""	""	""	""	"As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity)."	""	"FALSE"
"14083-25_3"	""	"SPS1"	"Selenide, water dikinase 1"	"10"	"13359424"	"13390298"	"SEPHS1"	"ENSG00000086475"	"P49903"	""	""	""	""	""	""	""	"Synthesizes selenophosphate from selenide and ATP."	""	"FALSE"
"14084-191_3"	""	"ICOS"	"Inducible T-cell costimulator"	"2"	"204801471"	"204826300"	"ICOS"	"ENSG00000163600"	"Q9Y6W8"	""	""	""	""	""	""	""	"Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity)."	""	"FALSE"
"14086-11_3"	""	"ASM3A"	"Acid sphingomyelinase-like phosphodiesterase 3a"	"6"	"123110194"	"123130865"	"SMPDL3A"	"ENSG00000172594"	"Q92484"	""	""	""	""	""	""	""	"Has in vitro nucleotide phosphodiesterase activity with nucleoside triphosphates, such as ATP (PubMed:25288789, PubMed:26783088). Has in vitro activity with p-nitrophenyl-TMP (PubMed:25288789). Has lower activity with nucleoside diphosphates, and no activity with nucleoside monophosphates (PubMed:25288789, PubMed:26783088). Has in vitro activity with CDP-choline, giving rise to CMP and phosphocholine. Has in vitro activity with CDP-ethanolamine (PubMed:26783088). Does not have sphingomyelin phosphodiesterase activity (PubMed:25288789, PubMed:26783088)."	""	"FALSE"
"14089-41_3"	""	"EphA5"	"Ephrin type-A receptor 5"	"4"	"66185281"	"66536213"	"EPHA5"	"ENSG00000145242"	"P54756"	""	""	""	""	""	""	""	"Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity)."	""	"FALSE"
"14091-42_3"	""	"Carbonyl reductase 3"	"Carbonyl reductase [NADPH] 3"	"21"	"37507210"	"37518864"	"CBR3"	"ENSG00000159231"	"O75828"	""	""	""	""	""	""	""	"Has low NADPH-dependent oxidoreductase activity towards 4-benzoylpyridine and menadione (in vitro)."	""	"FALSE"
"14094-29_3"	""	"HB-EGF"	"Heparin-binding EGF-like growth factor"	"5"	"139712428"	"139726216"	"HBEGF"	"ENSG00000113070"	"Q99075"	""	""	""	""	""	""	""	"Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor."	""	"FALSE"
"14097-86_3"	""	"ST4S6"	"Carbohydrate sulfotransferase 15"	"10"	"125767182"	"125853123"	"CHST15"	"ENSG00000182022"	"Q7LFX5"	""	""	""	""	""	""	""	"Sulfotransferase that transfers sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc(4,6-SO(4)) repeating units. It also transfers sulfate to a unique non-reducing terminal sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure found in thrombomodulin chondroitin sulfate. May also act as a B-cell receptor involved in BCR ligation-mediated early activation that mediate regulatory signals key to B-cell development and/or regulation of B-cell-specific RAG expression; however such results are unclear in vivo."	""	"FALSE"
"14100-63_3"	""	"C1QC"	"Complement C1q subcomponent subunit C"	"1"	"22970123"	"22974603"	"C1QC"	"ENSG00000159189"	"P02747"	""	""	""	""	""	""	""	"C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes."	""	"FALSE"
"14101-2_3"	""	"CNTFR alpha"	"Ciliary neurotrophic factor receptor subunit alpha"	"9"	"34551430"	"34590138"	"CNTFR"	"ENSG00000122756"	"P26992"	""	""	""	""	""	""	""	"Binds to CNTF. The alpha subunit provides the receptor specificity."	""	"FALSE"
"14103-12_3"	""	"TPSG1"	"Tryptase gamma"	"16"	"1271651"	"1275257"	"TPSG1"	"ENSG00000116176"	"Q9NRR2"	""	""	""	""	""	""	""	"Membrane"	""	"FALSE"
"14105-5_3"	""	"Kallistatin"	"Kallistatin"	"14"	"95027428"	"95036250"	"SERPINA4"	"ENSG00000100665"	"P29622"	""	""	""	""	""	""	""	"Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein."	""	"FALSE"
"14107-1_3"	""	"MTHFS"	"5-formyltetrahydrofolate cyclo-ligase"	"15"	"80125927"	"80189721"	"MTHFS"	"ENSG00000136371"	"P49914"	""	""	""	""	""	""	""	"Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate."	""	"FALSE"
"14109-15_3"	""	"MIP-5"	"C-C motif chemokine 15"	"17"	"34323476"	"34329084"	"CCL15"	"ENSG00000275718"	"Q16663"	""	""	""	""	""	""	""	"Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine A15."	""	"FALSE"
"14112-40_3"	""	"RELT"	"Tumor necrosis factor receptor superfamily member 19L"	"11"	"73087309"	"73108519"	"RELT"	"ENSG00000054967"	"Q969Z4"	""	""	""	""	""	""	""	"Mediates activation of NF-kappa-B. May play a role in T-cell activation."	""	"FALSE"
"14114-18_3"	""	"PIANP"	"PILR alpha-associated neural protein"	"12"	"6802958"	"6809966"	"PIANP"	"ENSG00000139200"	"Q8IYJ0"	""	""	""	""	""	""	""	"Acts as a ligand for PILRA in neural tissues, where it may be involved in immune regulation."	""	"FALSE"
"14115-34_3"	""	"Adrenomedullin"	"Adrenomedullin"	"11"	"10326227"	"10328944"	"ADM"	"ENSG00000148926"	"P35318"	""	""	""	""	""	""	""	"AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels."	""	"FALSE"
"14116-129_3"	""	"S100A4"	"Protein S100-A4"	"1"	"153516089"	"153522612"	"S100A4"	"ENSG00000196154"	"P26447"	""	""	""	""	""	""	""	"Homodimer. Interacts with PPFIBP1 in a calcium-dependent mode."	""	"FALSE"
"14123-34_3"	""	"GI24"	"Platelet receptor Gi24"	"10"	"73507316"	"73533255"	"C10orf54"	"ENSG00000107738"	"Q9H7M9"	""	""	""	""	""	""	""	"Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777)."	""	"FALSE"
"14133-93_3"	""	"IL-1 sRII"	"Interleukin-1 receptor type 2"	"2"	"102608306"	"102645006"	"IL1R2"	"ENSG00000115590"	"P27930"	""	""	""	""	""	""	""	"Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors."	""	"FALSE"
"14148-2_3"	""	"UCRP"	"Ubiquitin-like protein ISG15"	"1"	"936518"	"949921"	"ISG15"	"ENSG00000187608"	"P05161"	""	""	""	""	""	""	""	"Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. ISGylation involves a cascade of enzymatic reactions involving E1, E2, and E3 enzymes which catalyze the conjugation of ISG15 to a lysine residue in the target protein. Its target proteins include IFIT1, MX1/MxA, PPM1B, UBE2L6, UBA7, CHMP5, CHMP2A, CHMP4B and CHMP6. Can also isgylate: EIF2AK2/PKR which results in its activation, DDX58/RIG-I which inhibits its function in antiviral signaling response, EIF4E2 which enhances its cap structure-binding activity and translation-inhibition activity, UBE2N and UBE2E1 which negatively regulates their activity, IRF3 which inhibits its ubiquitination and degradation and FLNB which prevents its ability to interact with the upstream activators of the JNK cascade therby inhibiting IFNA-induced JNK signaling. Exhibits antiviral activity towards both DNA and RNA viruses, including influenza A, HIV-1 and Ebola virus. Restricts HIV-1 and ebola virus via disruption of viral budding. Inhibits the ubiquitination of HIV-1 Gag and host TSG101 and disrupts their interaction, thereby preventing assembly and release of virions from infected cells. Inhibits Ebola virus budding mediated by the VP40 protein by disrupting ubiquitin ligase activity of NEDD4 and its ability to ubiquitinate VP40. ISGylates influenza A virus NS1 protein which causes a loss of function of the protein and the inhibition of virus replication. The secreted form of ISG15 can: induce natural killer cell proliferation, act as a chemotactic factor for neutrophils and act as a IFN-gamma-inducing cytokine playing an essential role in antimycobacterial immunity."	""	"FALSE"
"14151-4_3"	""	"UCRP"	"Ubiquitin-like protein ISG15"	"1"	"936518"	"949921"	"ISG15"	"ENSG00000187608"	"P05161"	""	""	""	""	""	""	""	"Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. ISGylation involves a cascade of enzymatic reactions involving E1, E2, and E3 enzymes which catalyze the conjugation of ISG15 to a lysine residue in the target protein. Its target proteins include IFIT1, MX1/MxA, PPM1B, UBE2L6, UBA7, CHMP5, CHMP2A, CHMP4B and CHMP6. Can also isgylate: EIF2AK2/PKR which results in its activation, DDX58/RIG-I which inhibits its function in antiviral signaling response, EIF4E2 which enhances its cap structure-binding activity and translation-inhibition activity, UBE2N and UBE2E1 which negatively regulates their activity, IRF3 which inhibits its ubiquitination and degradation and FLNB which prevents its ability to interact with the upstream activators of the JNK cascade therby inhibiting IFNA-induced JNK signaling. Exhibits antiviral activity towards both DNA and RNA viruses, including influenza A, HIV-1 and Ebola virus. Restricts HIV-1 and ebola virus via disruption of viral budding. Inhibits the ubiquitination of HIV-1 Gag and host TSG101 and disrupts their interaction, thereby preventing assembly and release of virions from infected cells. Inhibits Ebola virus budding mediated by the VP40 protein by disrupting ubiquitin ligase activity of NEDD4 and its ability to ubiquitinate VP40. ISGylates influenza A virus NS1 protein which causes a loss of function of the protein and the inhibition of virus replication. The secreted form of ISG15 can: induce natural killer cell proliferation, act as a chemotactic factor for neutrophils and act as a IFN-gamma-inducing cytokine playing an essential role in antimycobacterial immunity."	""	"FALSE"
"14175-78_3"	""	"SCP2D"	"SCP2 sterol-binding domain-containing protein 1"	"20"	"18794370"	"18795036"	"SCP2D1"	"ENSG00000132631"	"Q9UJQ7"	""	""	""	""	""	""	""	""	""	"FALSE"
"14192-31_3"	""	"PDCL2"	"Phosducin-like protein 2"	"4"	"56422692"	"56458379"	"PDCL2"	"ENSG00000163440"	"Q8N4E4"	""	""	""	""	""	""	""	"May play a role in germ cell maturation."	""	"FALSE"
"14197-2_3"	""	"PRDM1"	"PR domain zinc finger protein 1"	"6"	"106534195"	"106557814"	"PRDM1"	"ENSG00000057657"	"O75626"	""	""	""	""	""	""	""	"Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (By similarity). Binds specifically to the PRDI element in the promoter of the beta-interferon gene (PubMed:1851123). Drives the maturation of B-lymphocytes into Ig secreting cells (PubMed:12626569). Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (By similarity)."	""	"FALSE"
"14204-55_3"	""	"FOXJ2"	"Forkhead box protein J2"	"12"	"8185299"	"8208099"	"FOXJ2"	"ENSG00000065970"	"Q9P0K8"	""	""	""	""	""	""	""	"Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2.L behaves as a more potent transactivator than FOXJ2.S."	""	"FALSE"
"14208-3_3"	""	"RET7"	"Retinoid-binding protein 7"	"1"	"10057264"	"10076078"	"RBP7"	"ENSG00000162444"	"Q96R05"	""	""	""	""	""	""	""	"Intracellular transport of retinol."	""	"FALSE"
"14222-68_3"	""	"S100A5"	"Protein S100-A5"	"1"	"153509623"	"153514241"	"S100A5"	"ENSG00000196420"	"P33763"	""	""	""	""	""	""	""	"Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites."	""	"FALSE"
"14246-50_3"	""	"DOK2"	"Docking protein 2"	"8"	"21766384"	"21771371"	"DOK2"	"ENSG00000147443"	"O60496"	""	""	""	""	""	""	""	"DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity)."	""	"FALSE"
"14254-27_3"	""	"PTN4"	"Tyrosine-protein phosphatase non-receptor type 4"	"2"	"120517207"	"120741394"	"PTPN4"	"ENSG00000088179"	"P29074"	""	""	""	""	""	""	""	"May act at junctions between the membrane and the cytoskeleton."	""	"FALSE"
"14268-4_3"	""	"SRXN1"	"Sulfiredoxin-1"	"20"	"627259"	"634014"	"SRXN1"	"ENSG00000271303"	"Q9BYN0"	""	""	""	""	""	""	""	"Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase."	""	"FALSE"
"14283-12_3"	""	"RAB14"	"Ras-related protein Rab-14"	"9"	"123940415"	"123985292"	"RAB14"	"ENSG00000119396"	"P61106"	""	""	""	""	""	""	""	"Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion."	""	"FALSE"
"14314-6_3"	""	"PPIL2"	"Peptidyl-prolyl cis-trans isomerase-like 2"	"22"	"22006559"	"22054304"	"PPIL2"	"ENSG00000100023"	"Q13356"	""	""	""	""	""	""	""	"Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation (PubMed:11435423). May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance (PubMed:15946952). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357)."	""	"FALSE"
"14318-1_3"	""	"VPS29"	"Vacuolar protein sorting-associated protein 29"	"12"	"110928902"	"110939922"	"VPS29"	"ENSG00000111237"	"Q9UBQ0"	""	""	""	""	""	""	""	"Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (Probable). Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with ANKRD27 (PubMed:24856514)."	""	"FALSE"
"14324-52_3"	""	"CSPG6"	"Structural maintenance of chromosomes protein 3"	"10"	"112327449"	"112364394"	"SMC3"	"ENSG00000108055"	"Q9UQE7"	""	""	""	""	""	""	""	"Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement."	""	"FALSE"
"14599-18_3"	""	"STAB1"	"Stabilin-1"	"3"	"52529354"	"52558511"	"STAB1"	"ENSG00000010327"	"Q9NY15"	""	""	""	""	""	""	""	"Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system."	""	"FALSE"
"14603-51_3"	""	"KIAA0040"	"Uncharacterized protein KIAA0040"	"1"	"175126123"	"175162135"	"KIAA0040"	"ENSG00000235750"	"J3QR46"	""	""	""	""	""	""	""	""	""	"FALSE"
"14615-46_3"	""	"KRA24"	"Keratin-associated protein 2-4"	"17"	"39221368"	"39222131"	"KRTAP2-4"	"ENSG00000213417"	"Q9BYR9"	""	""	""	""	""	""	""	"In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity)."	""	"FALSE"
"14623-26_3"	""	"SUMO3"	"Small ubiquitin-related modifier 3"	"21"	"46225532"	"46238694"	"SUMO3"	"ENSG00000184900"	"P55854"	""	""	""	""	""	""	""	"Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (PubMed:11451954, PubMed:18538659, PubMed:21965678). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744)."	""	"FALSE"
"14636-25_3"	""	"Ribonuclease UK114"	"Ribonuclease UK114"	"8"	"99114572"	"99129469"	"HRSP12"	"ENSG00000132541"	"P52758"	""	""	""	""	""	""	""	"Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase."	""	"FALSE"
"14643-27_3"	""	"KIN17"	"DNA/RNA-binding protein KIN17"	"10"	"7792925"	"7829944"	"KIN"	"ENSG00000151657"	"O60870"	""	""	""	""	""	""	""	"Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity). Binds via its C-terminal domain to RNA in vitro."	""	"FALSE"
"14645-253_3"	""	"GSTA4"	"Glutathione S-transferase A4"	"6"	"52842746"	"52860176"	"GSTA4"	"ENSG00000170899"	"O15217"	""	""	""	""	""	""	""	"Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal (4-HNE)."	""	"FALSE"
"14655-1_3"	""	"DJC17"	"DnaJ homolog subfamily C member 17"	"15"	"41057353"	"41099676"	"DNAJC17"	"ENSG00000104129"	"Q9NVM6"	""	""	""	""	""	""	""	"May negatively affect PAX8-induced thyroglobulin/TG transcription."	""	"FALSE"
"14663-44_3"	""	"RNF8"	"E3 ubiquitin-protein ligase RNF8"	"6"	"37321748"	"37362514"	"RNF8"	"ENSG00000112130"	"O76064"	""	""	""	""	""	""	""	"E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20/C1orf86 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains. Promotes non-homologous end joining (NHEJ) by promoting the 'Lys-48'-linked ubiquitination and degradation the of KU80/XRCC5. Following DNA damage, mediates the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF168, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites (PubMed:11322894, PubMed:14981089, PubMed:17724460, PubMed:18001824, PubMed:18001825, PubMed:18006705, PubMed:18077395, PubMed:18337245, PubMed:18948756, PubMed:19015238, PubMed:19124460, PubMed:19202061, PubMed:19203578, PubMed:19203579, PubMed:20550933, PubMed:21558560, PubMed:21857671, PubMed:21911360, PubMed:22266820, PubMed:22373579, PubMed:22531782, PubMed:22705371, PubMed:22865450, PubMed:22980979). Following DNA damage, mediates the ubiquitination and degradation of POLD4/p12, a subunit of DNA polymerase delta. In the absence of POLD4, DNA polymerase delta complex exhibits higher proofreading activity (PubMed:23233665). In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation. Involved in the activation of ATM by promoting histone H2B ubiquitination, which indirectly triggers histone H4 'Lys-16' acetylation (H4K16ac), establishing a chromatin environment that promotes efficient activation of ATM kinase. Required in the testis, where it plays a role in the replacement of histones during spermatogenesis. At uncapped telomeres, promotes the joining of deprotected chromosome ends by inducing H2A ubiquitination and TP53BP1 recruitment, suggesting that it may enhance cancer development by aggravating telomere-induced genome instability in case of telomeric crisis. Promotes the assembly of RAD51 at DNA DSBs in the absence of BRCA1 and TP53BP1 Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. May be required for proper exit from mitosis after spindle checkpoint activation and may regulate cytokinesis. May play a role in the regulation of RXRA-mediated transcriptional activity. Not involved in RXRA ubiquitination by UBE2E2 (PubMed:11322894, PubMed:14981089, PubMed:17724460, PubMed:18001824, PubMed:18001825, PubMed:18006705, PubMed:18077395, PubMed:18337245, PubMed:18948756, PubMed:19015238, PubMed:19124460, PubMed:19202061, PubMed:19203578, PubMed:19203579, PubMed:20550933, PubMed:21558560, PubMed:21857671, PubMed:21911360, PubMed:22266820, PubMed:22373579, PubMed:22531782, PubMed:22705371, PubMed:22865450, PubMed:22980979)."	""	"FALSE"
"14670-1_3"	""	"SKIL"	"Ski-like protein"	"3"	"170075466"	"170114623"	"SKIL"	"ENSG00000136603"	"P12757"	""	""	""	""	""	""	""	"May have regulatory role in cell division or differentiation in response to extracellular signals."	""	"FALSE"
"14675-20_3"	""	"IF4B"	"Eukaryotic translation initiation factor 4B"	"12"	"53399942"	"53435993"	"EIF4B"	"ENSG00000063046"	"P23588"	""	""	""	""	""	""	""	"Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F."	""	"FALSE"
"14684-17_3"	""	"CAN2"	"Calpain-2 catalytic subunit"	"1"	"223889295"	"223963720"	"CAPN2"	"ENSG00000162909"	"P17655"	""	""	""	""	""	""	""	"Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508). Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (By similarity)."	""	"FALSE"
"14685-17_3"	""	"PKB beta"	"RAC-beta serine/threonine-protein kinase"	"19"	"40736224"	"40791443"	"AKT2"	"ENSG00000105221"	"P31751"	""	""	""	""	""	""	""	"AKT2 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1. AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis. Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis. Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity. The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). AKT mediates the antiapoptotic effects of IGF-I. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. May be involved in the regulation of the placental development."	""	"FALSE"
"14688-6_3"	""	"PTN7"	"Tyrosine-protein phosphatase non-receptor type 7"	"1"	"202116141"	"202130716"	"PTPN7"	"ENSG00000143851"	"P35236"	""	""	""	""	""	""	""	"Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction."	""	"FALSE"
"14689-3_3"	""	"SEC13"	"Protein SEC13 homolog"	"3"	"10334815"	"10362862"	"SEC13"	"ENSG00000157020"	"P55735"	""	""	""	""	""	""	""	"Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles."	""	"FALSE"
"14692-3_3"	""	"ZN276"	"Zinc finger protein 276"	"16"	"89786808"	"89807311"	"ZNF276"	"ENSG00000158805"	"Q8N554"	""	""	""	""	""	""	""	"May be involved in transcriptional regulation."	""	"FALSE"
"14711-27_3"	""	"Cystatin M"	"Cystatin-M"	"11"	"65779312"	"65780976"	"CST6"	"ENSG00000175315"	"Q15828"	""	""	""	""	""	""	""	"Shows moderate inhibition of cathepsin B but is not active against cathepsin C."	""	"FALSE"
"2330-2_1"	""	"SDF-1"	"Stromal cell-derived factor 1"	"10"	"44865613"	"44881941"	"CXCL12"	"ENSG00000107562"	"P48061"	""	""	""	""	""	""	""	"Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner (PubMed:29301984). Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells (By similarity)."	""	"FALSE"
"2867-52_2"	""	"PKB a/b/g"	"RAC-alpha/beta/gamma serine/threonine-protein kinase"	"14|20|1"	"105235686|43514317|243651535"	"105262088|43537173|244014381"	"AKT1|YWHAB|AKT3"	"ENSG00000142208|ENSG00000166913|ENSG00000117020"	"P31749|P31946|Q9Y243"	""	""	""	""	""	""	""	"AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1. AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis. Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis. Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity. The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). AKT mediates the antiapoptotic effects of IGF-I. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. May be involved in the regulation of the placental development. Phosphorylates STK4/MST1 at 'Thr-120' and 'Thr-387' leading to inhibition of its: kinase activity, nuclear translocation, autophosphorylation and ability to phosphorylate FOXO3. Phosphorylates STK3/MST2 at 'Thr-117' and 'Thr-384' leading to inhibition of its: cleavage, kinase activity, autophosphorylation at Thr-180, binding to RASSF1 and nuclear translocation. Phosphorylates SRPK2 and enhances its kinase activity towards SRSF2 and ACIN1 and promotes its nuclear translocation. Phosphorylates RAF1 at 'Ser-259' and negatively regulates its activity. Phosphorylation of BAD stimulates its pro-apoptotic activity. Phosphorylates KAT6A at 'Thr-369' and this phosphorylation inhibits the interaction of KAT6A with PML and negatively regulates its acetylation activity towards p53/TP53.|Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.|AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis."	""	"FALSE"
"3309-2_2"	""	"FCG2A"	"Low affinity immunoglobulin gamma Fc region receptor II-a"	"1"	"161475220"	"161493803"	"FCGR2A"	"ENSG00000143226"	"P12318"	""	""	""	""	""	""	""	"Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens."	""	"FALSE"
"3607-71_6"	""	"DKK3"	"Dickkopf-related protein 3"	"11"	"11984653"	"12031316"	"DKK3"	"ENSG00000050165"	"Q9UBP4"	""	""	""	""	""	""	""	"Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity)."	""	"FALSE"
"3608-12_5"	""	"DPP2"	"Dipeptidyl peptidase 2"	"9"	"140004994"	"140009629"	"DPP7"	"ENSG00000176978"	"Q9UHL4"	""	""	""	""	""	""	""	"Plays an important role in the degradation of some oligopeptides."	""	"FALSE"
"3620-67_2"	""	"IL22RA1"	"Interleukin-22 receptor subunit alpha-1"	"1"	"24446261"	"24469611"	"IL22RA1"	"ENSG00000142677"	"Q8N6P7"	""	""	""	""	""	""	""	"Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation."	""	"FALSE"
"3633-70_5"	""	"NID2"	"Nidogen-2"	"14"	"52471521"	"52535946"	"NID2"	"ENSG00000087303"	"Q14112"	""	""	""	""	""	""	""	"Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix interactions."	""	"FALSE"
"3893-55_2"	""	"Mesothelin"	"Mesothelin"	"16"	"693262"	"818865"	"MSLN"	"ENSG00000102854"	"Q13421"	""	""	""	""	""	""	""	"Membrane-anchored forms may play a role in cellular adhesion."	""	"FALSE"
"4374-45_2"	""	"MIC-1"	"Growth/differentiation factor 15"	"19"	"18485541"	"18499986"	"GDF15"	"ENSG00000130513"	"Q99988"	""	""	""	""	""	""	""	"Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:23468844, PubMed:29046435). Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which contitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions (PubMed:28953886). On hepatocytes, inhibits growth hormone signaling (By similarity)."	""	"FALSE"
"4550-3_2"	""	"FYN"	"Tyrosine-protein kinase Fyn"	"6"	"111981535"	"112194655"	"FYN"	"ENSG00000010810"	"P06241"	""	""	""	""	""	""	""	"Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1."	""	"FALSE"
"4560-34_2"	""	"LCK"	"Tyrosine-protein kinase Lck"	"1"	"32716840"	"32751766"	"LCK"	"ENSG00000182866"	"P06239"	""	""	""	""	""	""	""	"Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP. Interacts with FYB2 (PubMed:27335501)."	""	"FALSE"
"4707-50_2"	""	"37694"	"14-3-3 protein family"	"2|1|7|17|22"	"9724101|27189629|75956111|1247566|32340447"	"9771143|27190948|75988348|1303672|32353590"	"YWHAQ|SFN|YWHAG|YWHAE|YWHAH"	"ENSG00000134308|ENSG00000175793|ENSG00000170027|ENSG00000108953|ENSG00000128245"	"P27348|P31947|P61981|P62258|Q04917"	""	""	""	""	""	""	""	"Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.|Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.|Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.|Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326).|Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1."	""	"FALSE"
"4998-50_2"	""	"JAK2"	"Tyrosine-protein kinase JAK2"	"9"	"4985033"	"5128183"	"JAK2"	"ENSG00000096968"	"O60674"	""	""	""	""	""	""	""	"Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins (PubMed:7615558). Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins (PubMed:9618263). Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B) (PubMed:21368206). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation (PubMed:20098430). Plays a role in cell cycle by phosphorylating CDKN1B (PubMed:21423214). Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin (PubMed:19783980)."	""	"FALSE"
"5124-62_3"	""	"sICAM-5"	"Intercellular adhesion molecule 5"	"19"	"10400657"	"10407454"	"ICAM5"	"ENSG00000105376"	"Q9UMF0"	""	""	""	""	""	""	""	"ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2)."	""	"FALSE"
"5247-17_4"	""	"Cyclophilin A"	"Peptidyl-prolyl cis-trans isomerase A"	"7"	"44836279"	"44864163"	"PPIA"	"ENSG00000196262"	"P62937"	""	""	""	""	""	""	""	"PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides."	""	"FALSE"
"5271-5_1"	""	"RAC3"	"Ras-related C3 botulinum toxin substrate 3"	"17"	"79989500"	"79992080"	"RAC3"	"ENSG00000169750"	"P60763"	""	""	""	""	""	""	""	"Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner."	""	"FALSE"
"5350-14_2"	""	"GPC6"	"Glypican-6"	"13"	"93879095"	"95059655"	"GPC6"	"ENSG00000183098"	"Q9Y625"	""	""	""	""	""	""	""	"Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (By similarity). Enhances migration and invasion of cancer cells through WNT5A signaling."	""	"FALSE"
"5353-89_2"	""	"IL-1Ra"	"Interleukin-1 receptor antagonist protein"	"2"	"113864791"	"113891593"	"IL1RN"	"ENSG00000136689"	"P18510"	""	""	""	""	""	""	""	"Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure."	""	"FALSE"
"5360-9_2"	""	"PKB beta"	"RAC-beta serine/threonine-protein kinase"	"19"	"40736224"	"40791443"	"AKT2"	"ENSG00000105221"	"P31751"	""	""	""	""	""	""	""	"AKT2 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1. AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis. Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis. Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity. The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). AKT mediates the antiapoptotic effects of IGF-I. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. May be involved in the regulation of the placental development."	""	"FALSE"
"5392-73_2"	""	"Fas, soluble"	"Tumor necrosis factor receptor superfamily member 6"	"10"	"90750288"	"90775542"	"FAS"	"ENSG00000026103"	"P25445"	""	""	""	""	""	""	""	"Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro)."	""	"FALSE"
"5430-66_3"	""	"SHPS1"	"Tyrosine-protein phosphatase non-receptor type substrate 1"	"20"	"1874813"	"1921238"	"SIRPA"	"ENSG00000198053"	"P78324"	""	""	""	""	""	""	""	"Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells."	""	"FALSE"
"5457-5_2"	""	"COLEC12"	"Collectin-12"	"18"	"316740"	"500722"	"COLEC12"	"ENSG00000158270"	"Q5KU26"	""	""	""	""	""	""	""	"Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid-beta in Alzheimer disease."	""	"FALSE"
"5464-52_3"	""	"GRB2 adapter protein"	"Growth factor receptor-bound protein 2"	"17"	"73314157"	"73401790"	"GRB2"	"ENSG00000177885"	"P62993"	""	""	""	""	""	""	""	"Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway."	""	"FALSE"
"5465-32_3"	""	"H6ST1"	"Heparan-sulfate 6-O-sulfotransferase 1"	"2"	"128994290"	"129076151"	"HS6ST1"	"ENSG00000136720"	"O60243"	""	""	""	""	""	""	""	"6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Critical for normal neuronal development where it may play a role in neuron branching. May also play a role in limb development. May prefer iduronic acid."	""	"FALSE"
"5470-69_2"	""	"MED-1"	"Mediator of RNA polymerase II transcription subunit 1"	"17"	"37560538"	"37607539"	"MED1"	"ENSG00000125686"	"Q15648"	""	""	""	""	""	""	""	"Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781)."	""	"FALSE"
"5481-16_3"	""	"RASA1"	"Ras GTPase-activating protein 1"	"5"	"86563705"	"86687748"	"RASA1"	"ENSG00000145715"	"P20936"	""	""	""	""	""	""	""	"Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the presence of NCK1."	""	"FALSE"
"5483-1_3"	""	"RGMA"	"Repulsive guidance molecule A"	"15"	"93578503"	"93632433"	"RGMA"	"ENSG00000182175"	"Q96B86"	""	""	""	""	""	""	""	"Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8."	""	"FALSE"
"5484-63_3"	""	"RS3A"	"40S ribosomal protein S3a"	"4"	"152020725"	"152025804"	"RPS3A"	"ENSG00000145425"	"P61247"	""	""	""	""	""	""	""	"May play a role during erythropoiesis through regulation of transcription factor DDIT3."	""	"FALSE"
"5486-73_3"	""	"sICAM-2"	"Intercellular adhesion molecule 2"	"17"	"62079954"	"62097994"	"ICAM2"	"ENSG00000108622"	"P13598"	""	""	""	""	""	""	""	"ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance."	""	"FALSE"
"5509-7_3"	""	"EGF"	"Epidermal growth factor"	"4"	"110834040"	"110933422"	"EGF"	"ENSG00000138798"	"P01133"	""	""	""	""	""	""	""	"EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro (PubMed:10964941)."	""	"FALSE"
"5584-21_3"	""	"TC II"	"Transcobalamin-2"	"22"	"31002825"	"31023265"	"TCN2"	"ENSG00000185339"	"P20062"	""	""	""	""	""	""	""	"Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells."	""	"FALSE"
"5586-66_3"	""	"MINP1"	"Multiple inositol polyphosphate phosphatase 1"	"10"	"89264632"	"89313217"	"MINPP1"	"ENSG00000107789"	"Q9UNW1"	""	""	""	""	""	""	""	"Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate. May play a role in bone development (endochondral ossification). May play a role in the transition of chondrocytes from proliferation to hypertrophy (By similarity)."	""	"FALSE"
"5593-11_3"	""	"PDIA5"	"Protein disulfide-isomerase A5"	"3"	"122785909"	"122944074"	"PDIA5"	"ENSG00000065485"	"Q14554"	""	""	""	""	""	""	""	"Catalyzes the rearrangement of -S-S- bonds in proteins."	""	"FALSE"
"5598-3_3"	""	"GREM2"	"Gremlin-2"	"1"	"240652873"	"240775449"	"GREM2"	"ENSG00000180875"	"Q9H772"	""	""	""	""	""	""	""	"Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells."	""	"FALSE"
"5599-88_3"	""	"PCYXL"	"Prenylcysteine oxidase-like"	"5"	"148737570"	"148749216"	"PCYOX1L"	"ENSG00000145882"	"Q8NBM8"	""	""	""	""	""	""	""	"Probable oxidoreductase."	""	"FALSE"
"5617-41_3"	""	"NPFF"	"Pro-FMRFamide-related neuropeptide FF"	"12"	"53900474"	"53901422"	"NPFF"	"ENSG00000139574"	"O15130"	""	""	""	""	""	""	""	"Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels."	""	"FALSE"
"5618-50_3"	""	"FAM3B"	"Protein FAM3B"	"21"	"42676139"	"42729358"	"FAM3B"	"ENSG00000183844"	"P58499"	""	""	""	""	""	""	""	"Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner."	""	"FALSE"
"5620-13_3"	""	"AMD"	"Peptidyl-glycine alpha-amidating monooxygenase"	"5"	"102089685"	"102366809"	"PAM"	"ENSG00000145730"	"P19021"	""	""	""	""	""	""	""	"Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity."	""	"FALSE"
"5621-64_3"	""	"THSD1"	"Thrombospondin type-1 domain-containing protein 1"	"13"	"52951302"	"52980629"	"THSD1"	"ENSG00000136114"	"Q9NS62"	""	""	""	""	""	""	""	"Isoform 1"	""	"FALSE"
"5627-53_3"	""	"GON1"	"Progonadoliberin-1"	"8"	"25276776"	"25282170"	"GNRH1"	"ENSG00000147437"	"P01148"	""	""	""	""	""	""	""	"Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones."	""	"FALSE"
"5628-21_3"	""	"SEM3G"	"Semaphorin-3G"	"3"	"52467069"	"52479101"	"SEMA3G"	"ENSG00000010319"	"Q9NS98"	""	""	""	""	""	""	""	"Has chemorepulsive activities for sympathetic axons. Ligand of NRP2 (By similarity)."	""	"FALSE"
"5630-48_3"	""	"CM35H"	"CMRF35-like molecule 8"	"17"	"72462555"	"72480935"	"CD300A"	"ENSG00000167851"	"Q9UGN4"	""	""	""	""	""	""	""	"Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation (PubMed:10746781, PubMed:16339535, PubMed:9701027). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (PubMed:22043923)."	""	"FALSE"
"5631-83_3"	""	"MOTI"	"Promotilin"	"6"	"33762450"	"33771788"	"MLN"	"ENSG00000096395"	"P12872"	""	""	""	""	""	""	""	"Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle."	""	"FALSE"
"5633-65_3"	""	"ILT-4"	"Leukocyte immunoglobulin-like receptor subfamily B member 2"	"19"	"54742780"	"54785039"	"LILRB2"	"ENSG00000131042"	"Q8N423"	""	""	""	""	""	""	""	"Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions."	""	"FALSE"
"5634-39_3"	""	"OFUT1"	"GDP-fucose protein O-fucosyltransferase 1"	"20"	"30795683"	"30826470"	"POFUT1"	"ENSG00000101346"	"Q9H488"	""	""	""	""	""	""	""	"Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can then extend the fucosylation on the NOTCH EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by DLL1 or JAGGED1. Fucosylates AGRN and determines its ability to cluster acetylcholine receptors (AChRs)."	""	"FALSE"
"5637-81_3"	""	"NTNG1"	"Netrin-G1"	"1"	"107682629"	"108026080"	"NTNG1"	"ENSG00000162631"	"Q9Y2I2"	""	""	""	""	""	""	""	"Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites."	""	"FALSE"
"5638-23_3"	""	"GT251"	"Procollagen galactosyltransferase 1"	"19"	"17666403"	"17693971"	"COLGALT1"	"ENSG00000130309"	"Q8NBJ5"	""	""	""	""	""	""	""	"Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of type I collagen (PubMed:19075007, PubMed:22216269, PubMed:27402836). By acting on collagen glycosylation, facilitates the formation of collagen triple helix (PubMed:27402836)."	""	"FALSE"
"5644-60_3"	""	"RNAS4"	"Ribonuclease 4"	"14"	"21152259"	"21169374"	"RNASE4"	"ENSG00000258818"	"P34096"	""	""	""	""	""	""	""	"This RNase has marked specificity towards the 3' side of uridine nucleotides."	""	"FALSE"
"5646-20_3"	""	"RNAS6"	"Ribonuclease K6"	"14"	"21249210"	"21250626"	"RNASE6"	"ENSG00000169413"	"Q93091"	""	""	""	""	""	""	""	"Ribonuclease which shows a preference for the pyrimidines uridine and cytosine (PubMed:8836175, PubMed:27013146). Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli (PubMed:25075772, PubMed:27089320). Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria (PubMed:27089320). Probably contributes to urinary tract sterility (PubMed:25075772). Bactericidal activity is independent of RNase activity (PubMed:27089320)."	""	"FALSE"
"5649-83_3"	""	"PSG4"	"Pregnancy-specific beta-1-glycoprotein 4"	"19"	"43696854"	"43711451"	"PSG4"	"ENSG00000243137"	"Q00888"	""	""	""	""	""	""	""	"Secreted"	""	"FALSE"
"5657-28_3"	""	"SIA4A"	"CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1"	"8"	"134467091"	"134584183"	"ST3GAL1"	"ENSG00000008513"	"Q11201"	""	""	""	""	""	""	""	"Responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found on sugar chains O-linked to Thr or Ser and also as a terminal sequence on certain gangliosides. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values."	""	"FALSE"
"5663-18_3"	""	"PF4V"	"Platelet factor 4 variant"	"4"	"74718906"	"74719872"	"PF4V1"	"ENSG00000109272"	"P10720"	""	""	""	""	""	""	""	"Inhibitor of angiogenesis. Inhibitor of endothelial cell chemotaxis (in vitro)."	""	"FALSE"
"5667-3_3"	""	"SEM3B"	"Semaphorin-3B"	"3"	"50304990"	"50314977"	"SEMA3B"	"ENSG00000012171"	"Q13214"	""	""	""	""	""	""	""	"Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons."	""	"FALSE"
"5669-26_3"	""	"SIRB2"	"Signal-regulatory protein beta-2"	"20"	"1451386"	"1472233"	"SIRPB2"	"ENSG00000196209"	"Q5JXA9"	""	""	""	""	""	""	""	"Membrane"	""	"FALSE"
"5671-1_3"	""	"Chymotrypsin"	"Chymotrypsinogen B"	"16"	"75252898"	"75258822"	"CTRB1"	"ENSG00000168925"	"P17538"	""	""	""	""	""	""	""	"Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa."	""	"FALSE"
"5675-6_3"	""	"PRELP"	"Prolargin"	"1"	"203444956"	"203460480"	"PRELP"	"ENSG00000188783"	"P51888"	""	""	""	""	""	""	""	"May anchor basement membranes to the underlying connective tissue."	""	"FALSE"
"5676-54_3"	""	"ASIP"	"Agouti-signaling protein"	"20"	"32782375"	"32857150"	"ASIP"	"ENSG00000101440"	"P42127"	""	""	""	""	""	""	""	"Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes."	""	"FALSE"
"5677-15_3"	""	"CB066"	"Uncharacterized protein C2orf66"	"2"	"197669726"	"197675000"	"C2orf66"	"ENSG00000187944"	"Q6UXQ4"	""	""	""	""	""	""	""	"Secreted"	""	"FALSE"
"5680-54_3"	""	"OBP2B"	"Odorant-binding protein 2b"	"9"	"136080664"	"136084637"	"OBP2B"	"ENSG00000171102"	"Q9NPH6"	""	""	""	""	""	""	""	"Probably binds and transports small hydrophobic volatile molecules."	""	"FALSE"
"5687-5_3"	""	"GLU2B"	"Glucosidase 2 subunit beta"	"19"	"11546109"	"11561783"	"PRKCSH"	"ENSG00000130175"	"P14314"	""	""	""	""	""	""	""	"Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins."	""	"FALSE"
"5688-65_3"	""	"CBLN4"	"Cerebellin-4"	"20"	"54572496"	"54580528"	"CBLN4"	"ENSG00000054803"	"Q9NTU7"	""	""	""	""	""	""	""	"May be involved in synaptic functions in the CNS. May play a role in CBLN3 export from the endoplasmic reticulum and secretion (By similarity)."	""	"FALSE"
"5689-1_3"	""	"DB112"	"Beta-defensin 112"	"6"	"50011288"	"50016364"	"DEFB112"	"ENSG00000180872"	"Q30KQ8"	""	""	""	""	""	""	""	"Has antibacterial activity."	""	"FALSE"
"5691-2_3"	""	"CRLD2"	"Cysteine-rich secretory protein LCCL domain-containing 2"	"16"	"84853590"	"84954374"	"CRISPLD2"	"ENSG00000103196"	"Q9H0B8"	""	""	""	""	""	""	""	"Promotes matrix assembly."	""	"FALSE"
"5698-60_3"	""	"Tenascin-X"	"Tenascin-X"	"6"	"32008931"	"32083111"	"TNXB"	"ENSG00000168477"	"P22105"	""	""	""	""	""	""	""	"Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors."	""	"FALSE"
"5699-19_3"	""	"CI061"	"Protein FAM189A2"	"9"	"71939488"	"72007371"	"FAM189A2"	"ENSG00000135063"	"Q15884"	""	""	""	""	""	""	""	"Membrane"	""	"FALSE"
"5704-74_3"	""	"Granzyme M"	"Granzyme M"	"19"	"544034"	"549924"	"GZMM"	"ENSG00000197540"	"P51124"	""	""	""	""	""	""	""	"Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells."	""	"FALSE"
"5707-55_3"	""	"ELK3"	"ETS domain-containing protein Elk-3"	"12"	"96588160"	"96663613"	"ELK3"	"ENSG00000111145"	"P41970"	""	""	""	""	""	""	""	"May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element."	""	"FALSE"
"5715-4_3"	""	"ABHEA"	"Alpha/beta hydrolase domain-containing protein 14A"	"3"	"52005442"	"52015215"	"ABHD14A"	"ENSG00000248487"	"Q9BUJ0"	""	""	""	""	""	""	""	"Possible role in granule neuron development."	""	"FALSE"
"5717-2_3"	""	"CILP"	"Cartilage intermediate layer protein 1"	"15"	"65487096"	"65503826"	"CILP"	"ENSG00000138615"	"O75339"	""	""	""	""	""	""	""	"Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage."	""	"FALSE"
"5721-1_3"	""	"CD226"	"CD226 antigen"	"18"	"67498394"	"67629039"	"CD226"	"ENSG00000150637"	"Q15762"	""	""	""	""	""	""	""	"Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell (PubMed:8673704). Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding (PubMed:26755705)."	""	"FALSE"
"5722-78_3"	""	"Prolylcarboxypeptidase"	"Lysosomal Pro-X carboxypeptidase"	"11"	"82534544"	"82681626"	"PRCP"	"ENSG00000137509"	"P42785"	""	""	""	""	""	""	""	"Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH."	""	"FALSE"
"5726-49_3"	""	"SG11A"	"Sperm-associated antigen 11A"	"8"	"7705398"	"7726389"	"SPAG11A"	"ENSG00000178287"	"Q6PDA7"	""	""	""	""	""	""	""	"May have antimicrobial activity. May also play a role sperm maturation, storage, and protection."	""	"FALSE"
"5728-60_3"	""	"FCRL1"	"Fc receptor-like protein 1"	"1"	"157764193"	"157789895"	"FCRL1"	"ENSG00000163534"	"Q96LA6"	""	""	""	""	""	""	""	"May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation."	""	"FALSE"
"5731-1_3"	""	"ISK6"	"Serine protease inhibitor Kazal-type 6"	"5"	"147582357"	"147594700"	"SPINK6"	"ENSG00000178172"	"Q6UWN8"	""	""	""	""	""	""	""	"Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit KLK8."	""	"FALSE"
"5735-54_3"	""	"C1GLC"	"C1GALT1-specific chaperone 1"	"X"	"119759648"	"119764005"	"C1GALT1C1"	"ENSG00000171155"	"Q96EU7"	""	""	""	""	""	""	""	"Probable chaperone required for the generation of 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1)."	""	"FALSE"
"5736-1_3"	""	"TRML2"	"Trem-like transcript 2 protein"	"6"	"41158015"	"41168932"	"TREML2"	"ENSG00000112195"	"Q5T2D2"	""	""	""	""	""	""	""	"Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation."	""	"FALSE"
"5737-61_3"	""	"SEM4D"	"Semaphorin-4D"	"9"	"91975702"	"92113045"	"SEMA4D"	"ENSG00000187764"	"Q92854"	""	""	""	""	""	""	""	"Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA."	""	"FALSE"
"5738-25_3"	""	"SP-C"	"Pulmonary surfactant-associated protein C"	"8"	"22014426"	"22021992"	"SFTPC"	"ENSG00000168484"	"P11686"	""	""	""	""	""	""	""	"Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces."	""	"FALSE"
"5739-75_3"	""	"KTDAP"	"Keratinocyte differentiation-associated protein"	"19"	"35978226"	"35986460"	"KRTDAP"	"ENSG00000188508"	"P60985"	""	""	""	""	""	""	""	"May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis."	""	"FALSE"
"5744-12_3"	""	"CA056"	"Protein MENT"	"1"	"151020216"	"151024462"	"MENT"	"ENSG00000143443"	"Q9BUN1"	""	""	""	""	""	""	""	"Involved in control of cellular proliferation. Onconcogenic modifier contributing to the tumor suppressor function of DNMT3B."	""	"FALSE"
"5746-37_3"	""	"EFNB1"	"Ephrin-B1"	"X"	"68048840"	"68061990"	"EFNB1"	"ENSG00000090776"	"P98172"	""	""	""	""	""	""	""	"Binds to the receptor tyrosine kinases EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity)."	""	"FALSE"
"5748-20_3"	""	"Acid ceramidase"	"Acid ceramidase"	"8"	"17913934"	"17942494"	"ASAH1"	"ENSG00000104763"	"Q13510"	""	""	""	""	""	""	""	"Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid."	""	"FALSE"
"5749-53_3"	""	"COL"	"Colipase"	"6"	"35762759"	"35765121"	"CLPS"	"ENSG00000137392"	"P04118"	""	""	""	""	""	""	""	"Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase."	""	"FALSE"
"5763-67_3"	""	"HBD-4"	"Beta-defensin 104"	"8|8"	"7327830|7693993"	"7332604|7698764"	"DEFB104A|DEFB104A"	"ENSG00000177023|ENSG00000176782"	"Q8WTQ1|Q8WTQ1"	""	""	""	""	""	""	""	"Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103."	""	"FALSE"
"5810-25_3"	""	"Cripto"	"Teratocarcinoma-derived growth factor 1"	"3"	"46616045"	"46668033"	"TDGF1"	"ENSG00000241186"	"P13385"	""	""	""	""	""	""	""	"GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated TDGF1 acts as a Nodal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells (PubMed:27881714). Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm (PubMed:11909953)."	""	"FALSE"
"5825-49_3"	""	"IFN-g R1"	"Interferon gamma receptor 1"	"6"	"137518621"	"137540586"	"IFNGR1"	"ENSG00000027697"	"P15260"	""	""	""	""	""	""	""	"Associates with IFNGR2 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:7615558, PubMed:2971451, PubMed:7617032, PubMed:10986460). Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:7673114). Plays an essential role in the IFN-gamma pathway that is required for the cellular response to infectious agents (PubMed:20015550)."	""	"FALSE"
"5837-49_3"	""	"LIF sR"	"Leukemia inhibitory factor receptor"	"5"	"38475065"	"38608456"	"LIFR"	"ENSG00000113594"	"P42702"	""	""	""	""	""	""	""	"Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells."	""	"FALSE"
"5843-60_3"	""	"NG36"	"Histone-lysine N-methyltransferase EHMT2"	"6"	"31847536"	"31865464"	"EHMT2"	"ENSG00000204371"	"Q96KQ7"	""	""	""	""	""	""	""	"Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself."	""	"FALSE"
"5846-24_3"	""	"Noggin"	"Noggin"	"17"	"54671060"	"54672951"	"NOG"	"ENSG00000183691"	"Q13253"	""	""	""	""	""	""	""	"Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6 (PubMed:21976273, PubMed:26643732)."	""	"FALSE"
"5852-6_3"	""	"S100A12"	"Protein S100-A12"	"1"	"153346182"	"153348125"	"S100A12"	"ENSG00000163221"	"P80511"	""	""	""	""	""	""	""	"S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus."	""	"FALSE"
"5858-6_5"	""	"14-3-3 protein zeta/delta"	"14-3-3 protein zeta/delta"	"8"	"101928753"	"101965616"	"YWHAZ"	"ENSG00000164924"	"P63104"	""	""	""	""	""	""	""	"Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner."	""	"FALSE"
"5861-78_3"	""	"3HAO"	"3-hydroxyanthranilate 3,4-dioxygenase"	"2"	"42994229"	"43019733"	"HAAO"	"ENSG00000162882"	"P46952"	""	""	""	""	""	""	""	"Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate."	""	"FALSE"
"5864-10_3"	""	"aldolase A"	"Fructose-bisphosphate aldolase A"	"16"	"30064411"	"30081778"	"ALDOA"	"ENSG00000149925"	"P04075"	""	""	""	""	""	""	""	"Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity)."	""	"FALSE"
"5888-29_3"	""	"eIF-5A-1"	"Eukaryotic translation initiation factor 5A-1"	"17"	"7210318"	"7215782"	"EIF5A"	"ENSG00000132507"	"P63241"	""	""	""	""	""	""	""	"mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts."	""	"FALSE"
"5900-11_2"	""	"HINT1"	"Histidine triad nucleotide-binding protein 1"	"5"	"130494720"	"130507428"	"HINT1"	"ENSG00000169567"	"P49773"	""	""	""	""	""	""	""	"Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex."	""	"FALSE"
"5909-51_3"	""	"Nucleoside diphosphate kinase A"	"Nucleoside diphosphate kinase A"	"17"	"49230897"	"49239789"	"NME1"	"ENSG00000239672"	"P15531"	""	""	""	""	""	""	""	"Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair."	""	"FALSE"
"5918-5_3"	""	"PSME1"	"Proteasome activator complex subunit 1"	"14"	"24605367"	"24608176"	"PSME1"	"ENSG00000092010"	"Q06323"	""	""	""	""	""	""	""	"Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome."	""	"FALSE"
"5927-4_3"	""	"WISP-3"	"WNT1-inducible-signaling pathway protein 3"	"6"	"112375275"	"112392172"	"wisp3"	"ENSG00000112761"	"O95389"	""	""	""	""	""	""	""	"Appears to be required for normal postnatal skeletal growth and cartilage homeostasis."	""	"FALSE"
"5930-54_3"	""	"Troponin I"	"Troponin I, cardiac muscle"	"19"	"55663135"	"55669141"	"TNNI3"	"ENSG00000129991"	"P19429"	""	""	""	""	""	""	""	"Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity."	""	"FALSE"
"5939-42_3"	""	"TWEAK"	"Tumor necrosis factor ligand superfamily member 12"	"17"	"7452208"	"7461207"	"TNFSF12"	"ENSG00000239697"	"O43508"	""	""	""	""	""	""	""	"Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion."	""	"FALSE"
"5960-49_3"	""	"SG1C1"	"Secretoglobin family 1C member 1"	"11"	"193080"	"194573"	"SCGB1C1"	"ENSG00000188076"	"Q8TD33"	""	""	""	""	""	""	""	"Secreted"	""	"FALSE"
"6019-12_3"	""	"C1T9A"	"Complement C1q and tumor necrosis factor-related protein 9A"	"13"	"24881304"	"24896673"	"C1QTNF9"	"ENSG00000240654"	"P0C862"	""	""	""	""	""	""	""	"Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways."	""	"FALSE"
"6039-24_3"	""	"CRHBP"	"Corticotropin-releasing factor-binding protein"	"5"	"76248538"	"76276983"	"CRHBP"	"ENSG00000145708"	"P24387"	""	""	""	""	""	""	""	"Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy."	""	"FALSE"
"6042-52_3"	""	"OFUT2"	"GDP-fucose protein O-fucosyltransferase 2"	"21"	"46683843"	"46707813"	"POFUT2"	"ENSG00000186866"	"Q9Y2G5"	""	""	""	""	""	""	""	"Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm (By similarity). Required for the proper secretion of ADAMTS family members such as ADAMSL1 and ADAMST13."	""	"FALSE"
"6048-4_3"	""	"SIG10"	"Sialic acid-binding Ig-like lectin 10"	"19"	"51913275"	"51921057"	"SIGLEC10"	"ENSG00000142512"	"Q96LC7"	""	""	""	""	""	""	""	"Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid (By similarity). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules (PubMed:11284738, PubMed:12163025). Involved in negative regulation of B-cell antigen receptor signaling. The inhibition of B cell activation is dependent on PTPN6/SHP-1 (By similarity). In association with CD24 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90 (By similarity). In association with CD24 may regulate the immune repsonse of natural killer (NK) cells (PubMed:25450598). Plays a role in the control of autoimmunity (By similarity). During initiation of adaptive immune responses by CD8-alpha(+) dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. The function seems to implicate recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex consequently promoting phagosomal acidification (By similarity)."	""	"FALSE"
"6064-4_3"	""	"TXNDC4"	"Endoplasmic reticulum resident protein 44"	"9"	"102741461"	"102861322"	"ERP44"	"ENSG00000023318"	"Q9BS26"	""	""	""	""	""	""	""	"Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1A and ERO1B in the endoplasmic reticulum."	""	"FALSE"
"6070-11_3"	""	"QSCN6"	"Sulfhydryl oxidase 1"	"1"	"180123969"	"180173165"	"QSOX1"	"ENSG00000116260"	"O00391"	""	""	""	""	""	""	""	"Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. In fibroblasts, it may have tumor-suppressing capabilities being involved in growth regulation."	""	"FALSE"
"6077-63_3"	""	"CECR1"	"Adenosine deaminase CECR1"	"22"	"17659680"	"17702879"	"CECR1"	"ENSG00000093072"	"Q9NZK5"	""	""	""	""	""	""	""	"Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity."	""	"FALSE"
"6079-59_3"	""	"ACPL2"	"2-phosphoxylose phosphatase 1"	"3"	"140947568"	"141013748"	"PXYLP1"	"ENSG00000155893"	"Q8TE99"	""	""	""	""	""	""	""	"Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains."	""	"FALSE"
"6081-52_3"	""	"PCOC2"	"Procollagen C-endopeptidase enhancer 2"	"3"	"142534764"	"142608045"	"PCOLCE2"	"ENSG00000163710"	"Q9UKZ9"	""	""	""	""	""	""	""	"Binds to the C-terminal propeptide of types I and II procollagens and may enhance the cleavage of that propeptide by BMP1."	""	"FALSE"
"6086-15_3"	""	"CRDL2"	"Chordin-like protein 2"	"11"	"74407474"	"74442430"	"CHRDL2"	"ENSG00000054938"	"Q6WN34"	""	""	""	""	""	""	""	"May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation."	""	"FALSE"
"6115-40_3"	""	"DIAC"	"Di-N-acetylchitobiase"	"1"	"85015289"	"85040163"	"CTBS"	"ENSG00000117151"	"Q01459"	""	""	""	""	""	""	""	"Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N-acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase."	""	"FALSE"
"6151-18_3"	""	"MP2K3"	"Dual specificity mitogen-activated protein kinase kinase 3"	"17"	"21187984"	"21218552"	"MAP2K3"	"ENSG00000034152"	"P46734"	""	""	""	""	""	""	""	"Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14."	""	"FALSE"
"6152-111_3"	""	"p53"	"Cellular tumor antigen p53"	"17"	"7565097"	"7590868"	"TP53"	"ENSG00000141510"	"P04637"	""	""	""	""	""	""	""	"Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492)."	""	"FALSE"
"6217-23_3"	""	"QSCN6"	"Sulfhydryl oxidase 1"	"1"	"180123969"	"180173165"	"QSOX1"	"ENSG00000116260"	"O00391"	""	""	""	""	""	""	""	"Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. In fibroblasts, it may have tumor-suppressing capabilities being involved in growth regulation."	""	"FALSE"
"6234-74_3"	""	"VITRN"	"Vitrin"	"2"	"36923833"	"37041935"	"VIT"	"ENSG00000205221"	"Q6UXI7"	""	""	""	""	""	""	""	"Promotes matrix assembly and cell adhesiveness."	""	"FALSE"
"6247-9_3"	""	"SIRB1"	"Signal-regulatory protein beta-1"	"20"	"1544167"	"1600707"	"SIRPB1"	"ENSG00000101307"	"O00241"	""	""	""	""	""	""	""	"Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK."	""	"FALSE"
"6255-74_3"	""	"CPXM1"	"Probable carboxypeptidase X1"	"20"	"2774715"	"2781283"	"CPXM1"	"ENSG00000088882"	"Q96SM3"	""	""	""	""	""	""	""	"May be involved in cell-cell interactions. No carboxypeptidase activity was found yet (By similarity)."	""	"FALSE"
"6256-9_3"	""	"LY66C"	"Lymphocyte antigen 6 complex locus protein G6c"	"6"	"31686425"	"31689622"	"LY6G6C"	"ENSG00000204421"	"O95867"	""	""	""	""	""	""	""	"Monomer."	""	"FALSE"
"6257-56_3"	""	"CGRE1"	"Cell growth regulator with EF hand domain protein 1"	"2"	"27321757"	"27341983"	"CGREF1"	"ENSG00000138028"	"Q99674"	""	""	""	""	""	""	""	"Mediates cell-cell adhesion in a calcium-dependent manner (By similarity). Able to inhibit growth in several cell lines."	""	"FALSE"
"6259-60_3"	""	"Epididymal secretory protein E1"	"Epididymal secretory protein E1"	"14"	"74942895"	"74960880"	"NPC2"	"ENSG00000119655"	"P61916"	""	""	""	""	""	""	""	"Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport."	""	"FALSE"
"6260-14_3"	""	"F163A"	"Protein FAM163A"	"1"	"179712298"	"179785333"	"FAM163A"	"ENSG00000143340"	"Q96GL9"	""	""	""	""	""	""	""	"Membrane"	""	"FALSE"
"6267-51_3"	""	"STMN4"	"Stathmin-4"	"8"	"27092840"	"27115937"	"STMN4"	"ENSG00000015592"	"Q9H169"	""	""	""	""	""	""	""	"Exhibits microtubule-destabilizing activity."	""	"FALSE"
"6274-15_3"	""	"WSCD2"	"WSC domain-containing protein 2"	"12"	"108523248"	"108644314"	"WSCD2"	"ENSG00000075035"	"Q2TBF2"	""	""	""	""	""	""	""	"Membrane"	""	"FALSE"
"6276-16_3"	""	"Furin"	"Furin"	"15"	"91411822"	"91426688"	"FURIN"	"ENSG00000140564"	"P09958"	""	""	""	""	""	""	""	"Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif."	""	"FALSE"
"6283-60_3"	""	"MCEM1"	"Mast cell-expressed membrane protein 1"	"19"	"7741514"	"7744712"	"MCEMP1"	"ENSG00000183019"	"Q8IX19"	""	""	""	""	""	""	""	"EBI-2816356"	""	"FALSE"
"6284-7_3"	""	"F150B"	"Protein FAM150B"	"2"	"279558"	"288851"	"FAM150B"	"ENSG00000189292"	"Q6UX46"	""	""	""	""	""	""	""	"Ligand for receptor tyrosine kinases LTK and ALK. Stimulation of ALK signaling may be involved in regulation of cell proliferation and transformation."	""	"FALSE"
"6294-11_3"	""	"BAGE2"	"B melanoma antigen 2"	"21"	"10996025"	"11098979"	"BAGE2"	"ENSG00000187172"	"Q86Y30"	""	""	""	""	""	""	""	"Unknown. Candidate gene encoding tumor antigens."	""	"FALSE"
"6295-67_3"	""	"VCY1"	"Testis-specific basic protein Y 1"	"Y"	"16168097"	"16168838"	"VCY"	"ENSG00000129862"	"O14598"	""	""	""	""	""	""	""	"May mediate a process in spermatogenesis or may play a role in sex ratio distortion."	""	"FALSE"
"6304-8_3"	""	"C1QT1"	"Complement C1q tumor necrosis factor-related protein 1"	"17"	"77018896"	"77045870"	"C1QTNF1"	"ENSG00000173918"	"Q9BXJ1"	""	""	""	""	""	""	""	"EBI-750200"	""	"FALSE"
"6334-9_3"	""	"GGT2"	"Inactive gamma-glutamyltranspeptidase 2"	"22"	"21562262"	"21581926"	"GGT2"	"ENSG00000133475"	"P36268"	""	""	""	""	""	""	""	"Isoform 1, isoform 2 and isoform 3 lack catalytic activity due to its inability to undergo the autocatalytic cleavage needed to produce a mature, enzymatically active heterodimer."	""	"FALSE"
"6353-60_3"	""	"IGFL4"	"Insulin growth factor-like family member 4"	"19"	"46543006"	"46580376"	"IGFL4"	"ENSG00000204869"	"Q6B9Z1"	""	""	""	""	""	""	""	"Secreted"	""	"FALSE"
"6356-3_3"	""	"Carboxypeptidase B1"	"Carboxypeptidase B"	"3"	"148508889"	"148577974"	"CPB1"	"ENSG00000153002"	"P15086"	""	""	""	""	""	""	""	"Preferential release of a C-terminal lysine or arginine amino acid."	""	"FALSE"
"6359-50_3"	""	"AGO61"	"Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2"	"3"	"43120724"	"43147568"	"POMGNT2"	"ENSG00000144647"	"Q8NAT1"	""	""	""	""	""	""	""	"O-linked mannose beta-1,4-N-acetylglucosaminyltransferase that transfers UDP-N-acetyl-D-glucosamine to the 4-position of the mannose to generate N-acetyl-D-glucosamine-beta-1,4-O-D-mannosylprotein. Involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity."	""	"FALSE"
"6360-7_3"	""	"DB128"	"Beta-defensin 128"	"20"	"168494"	"170322"	"DEFB128"	"ENSG00000185982"	"Q7Z7B8"	""	""	""	""	""	""	""	"Has antibacterial activity."	""	"FALSE"
"6362-6_3"	""	"AUGN"	"Augurin"	"2"	"106679702"	"106694615"	"C2orf40"	"ENSG00000119147"	"Q9H1Z8"	""	""	""	""	""	""	""	"Probable hormone that may induce senescence of oligodendrocyte and neural precursor cells, characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation."	""	"FALSE"
"6364-7_3"	""	"TPSNR"	"Tapasin-related protein"	"12"	"6560856"	"6575683"	"TAPBPL"	"ENSG00000139192"	"Q9BX59"	""	""	""	""	""	""	""	"Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2-microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC). Expression seems to slow down and down-regulate MHC class I surface expression."	""	"FALSE"
"6369-82_3"	""	"DEAF1"	"Deformed epidermal autoregulatory factor 1 homolog"	"11"	"644233"	"706715"	"DEAF1"	"ENSG00000177030"	"O75398"	""	""	""	""	""	""	""	"Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Required for neural tube closure and skeletal patterning. Regulates epithelial cell proliferation and side-branching in the mammary gland. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 4. Isoform 4 may inhibit transcriptional activity of isoform 1 by interacting with isoform 1 and retaining it in the cytoplasm. Transcriptional activator of EIF4G3."	""	"FALSE"
"6372-7_3"	""	"YBOX2"	"Y-box-binding protein 2"	"17"	"7191571"	"7197934"	"YBX2"	"ENSG00000006047"	"Q9Y2T7"	""	""	""	""	""	""	""	"Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full-length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay (By similarity)."	""	"FALSE"
"6373-54_3"	""	"SEMG2"	"Semenogelin-2"	"20"	"43849941"	"43853099"	"SEMG2"	"ENSG00000124157"	"Q02383"	""	""	""	""	""	""	""	"Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa."	""	"FALSE"
"6375-75_3"	""	"XXLT1"	"Xyloside xylosyltransferase 1"	"3"	"194789008"	"194991896"	"XXYLT1"	"ENSG00000173950"	"Q8NBI6"	""	""	""	""	""	""	""	"Alpha-1,3-xylosyltransferase, which elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats in the extracellular domain of target proteins by catalyzing the addition of the second xylose (PubMed:22117070, PubMed:8982869). Known targets include Notch proteins and coagulation factors, such as F9 (PubMed:22117070, PubMed:8982869)."	""	"FALSE"
"6377-54_3"	""	"LYZL2"	"Lysozyme-like protein 2"	"10"	"30900708"	"30918691"	"LYZD2"	"ENSG00000151033"	"Q7Z4W2"	""	""	""	""	""	""	""	"Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins."	""	"FALSE"
"6378-2_3"	""	"CEI"	"Protein CEI"	"5"	"2752245"	"2755511"	"C5orf38"	"ENSG00000186493"	"Q86SI9"	""	""	""	""	""	""	""	"Secreted"	""	"FALSE"
"6382-17_3"	""	"MANBA"	"Beta-mannosidase"	"4"	"103552645"	"103682151"	"MANBA"	"ENSG00000109323"	"O00462"	""	""	""	""	""	""	""	"Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides."	""	"FALSE"
"6383-90_3"	""	"TLL1"	"Tolloid-like protein 1"	"4"	"166794410"	"167025047"	"TLL1"	"ENSG00000038295"	"O43897"	""	""	""	""	""	""	""	"Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis."	""	"FALSE"
"6384-19_3"	""	"WFDC3"	"WAP four-disulfide core domain protein 3"	"20"	"44376583"	"44420571"	"WFDC3"	"ENSG00000124116"	"Q8IUB2"	""	""	""	""	""	""	""	"Secreted"	""	"FALSE"
"6388-21_3"	""	"CC126"	"Coiled-coil domain-containing protein 126"	"7"	"23636998"	"23684327"	"CCDC126"	"ENSG00000169193"	"Q96EE4"	""	""	""	""	""	""	""	"Secreted"	""	"FALSE"
"6393-63_3"	""	"Endoplasmin"	"Endoplasmin"	"12"	"104323885"	"104347423"	"HSP90B1"	"ENSG00000166598"	"P14625"	""	""	""	""	""	""	""	"Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity."	""	"FALSE"
"6395-58_3"	""	"GPHA2"	"Glycoprotein hormone alpha-2"	"11"	"64701943"	"64703360"	"GPHA2"	"ENSG00000149735"	"Q96T91"	""	""	""	""	""	""	""	"Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production (PubMed:12045258). Plays a central role in controlling thyroid cell metabolism (PubMed:12045258)."	""	"FALSE"
"6398-12_3"	""	"LONM"	"Lon protease homolog, mitochondrial"	"19"	"5691845"	"5720583"	"LONP1"	"ENSG00000196365"	"P36776"	""	""	""	""	""	""	""	"ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters (PubMed:12198491, PubMed:15870080, PubMed:17420247, PubMed:8248235). Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, helicase Twinkle (TWNK) and the large ribosomal subunit protein bL32m. bL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not (PubMed:17579211, PubMed:28377575)."	""	"FALSE"
"6401-73_3"	""	"SLUR1"	"Secreted Ly-6/uPAR-related protein 1"	"8"	"143822362"	"143823829"	"SLURP1"	"ENSG00000126233"	"P55000"	""	""	""	""	""	""	""	"Has an antitumor activity (PubMed:8742060). Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin (PubMed:14721776, PubMed:17008884). In vitro down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-7-dependent nAChR currents in an allosteric manner (PubMed:14506129, PubMed:26905431). In T cells may be involved in regulation of intracellular Ca(2+) signaling (PubMed:17286989). Seems to have a immunomodulatory function in the cornea (By similarity). The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation (PubMed:25168896)."	""	"FALSE"
"6406-3_3"	""	"NMES1"	"Normal mucosa of esophagus-specific gene 1 protein"	"15"	"45722727"	"45740959"	"NMES1"	"ENSG00000166920"	"Q9C002"	""	""	""	""	""	""	""	"Nucleus"	""	"FALSE"
"6408-2_3"	""	"INHBC"	"Inhibin beta C chain"	"12"	"57828543"	"57844611"	"INHBC"	"ENSG00000175189"	"P55103"	""	""	""	""	""	""	""	"Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins."	""	"FALSE"
"6409-57_3"	""	"GP116"	"Adhesion G protein-coupled receptor F5"	"6"	"46820249"	"46922680"	"GPR116"	"ENSG00000069122"	"Q8IZF2"	""	""	""	""	""	""	""	"Receptor that plays a critical role in lung surfactant homeostasis. May play a role in controlling adipocyte function."	""	"FALSE"
"6414-8_3"	""	"OAF"	"Out at first protein homolog"	"11"	"120081475"	"120101041"	"OAF"	"ENSG00000184232"	"Q86UD1"	""	""	""	""	""	""	""	"Belongs to the OAF family."	""	"FALSE"
"6433-57_3"	""	"FA20A"	"Pseudokinase FAM20A"	"17"	"66531254"	"66597530"	"FAM20A"	"ENSG00000108950"	"Q96MK3"	""	""	""	""	""	""	""	"Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals."	""	"FALSE"
"6439-59_3"	""	"CN093"	"Uncharacterized protein C14orf93"	"14"	"23455117"	"23479375"	"C14orf93"	"ENSG00000100802"	"Q9H972"	""	""	""	""	""	""	""	"EBI-10329620"	""	"FALSE"
"6441-62_3"	""	"ATS6"	"A disintegrin and metalloproteinase with thrombospondin motifs 6"	"5"	"64444563"	"64777747"	"ADAMTS6"	"ENSG00000049192"	"Q9UKP5"	""	""	""	""	""	""	""	"Zn(2+)"	""	"FALSE"
"6444-15_3"	""	"PSG3"	"Pregnancy-specific beta-1-glycoprotein 3"	"19"	"43225790"	"43244721"	"PSG3"	"ENSG00000221826"	"Q16557"	""	""	""	""	""	""	""	"Secreted"	""	"FALSE"
"6448-36_3"	""	"Sema E"	"Semaphorin-3C"	"7"	"80371854"	"80551675"	"SEMA3C"	"ENSG00000075223"	"Q99985"	""	""	""	""	""	""	""	"Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance (By similarity)."	""	"FALSE"
"6451-64_3"	""	"ASPN"	"Asporin"	"9"	"95218487"	"95244788"	"ASPN"	"ENSG00000106819"	"Q9BXN1"	""	""	""	""	""	""	""	"Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity."	""	"FALSE"
"6453-70_3"	""	"LIRB4"	"Leukocyte immunoglobulin-like receptor subfamily B member 4"	"19"	"55155340"	"55181810"	"LILRB4"	"ENSG00000186818"	"Q8NHJ6"	""	""	""	""	""	""	""	"Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions."	""	"FALSE"
"6454-38_3"	""	"Rho-GDIa"	"Rho GDP-dissociation inhibitor 1"	"17"	"79825597"	"79829282"	"ARHGDIA"	"ENSG00000141522"	"P52565"	""	""	""	""	""	""	""	"Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1."	""	"FALSE"
"6458-6_3"	""	"RPN1"	"Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1"	"3"	"128338813"	"128399918"	"RPN1"	"ENSG00000163902"	"P04843"	""	""	""	""	""	""	""	"Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains."	""	"FALSE"
"6462-12_3"	""	"TIMP-4"	"Metalloproteinase inhibitor 4"	"3"	"12194551"	"12200851"	"TIMP4"	"ENSG00000157150"	"Q99727"	""	""	""	""	""	""	""	"Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9."	""	"FALSE"
"6466-7_3"	""	"SPAC7"	"Protein SPACA7"	"13"	"113030633"	"113089003"	"SPACA7"	"ENSG00000153498"	"Q96KW9"	""	""	""	""	""	""	""	"Involved in fertilization. Seems not to play a direct role in sperm-egg binding or gamete fusion."	""	"FALSE"
"6467-65_3"	""	"KTEL1"	"Protein O-glucosyltransferase 1"	"3"	"119187785"	"119213555"	"POGLUT1"	"ENSG00000163389"	"Q8NBL1"	""	""	""	""	""	""	""	"Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C-X-S-X-P-C (PubMed:21081508, PubMed:21490058, PubMed:21949356, PubMed:27807076). Specifically targets extracellular EGF repeats of protein such as CRB2, F7, F9 and NOTCH2 (PubMed:21081508, PubMed:21490058, PubMed:21949356, PubMed:27807076). Acts as a positive regulator of Notch signaling by mediating O-glucosylation of Notch, leading to regulate muscle development (PubMed:27807076). Notch glucosylation does not affect Notch ligand binding (PubMed:21490058). Required during early development to promote gastrulation: acts by mediating O-glucosylation of CRB2, which is required for CRB2 localization to the cell membrane (By similarity)."	""	"FALSE"
"6472-40_3"	""	"GP100"	"Melanocyte protein PMEL"	"12"	"56347889"	"56367101"	"PMEL"	"ENSG00000185664"	"P40967"	""	""	""	""	""	""	""	"Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity."	""	"FALSE"
"6485-59_3"	""	"IGLL1"	"Immunoglobulin lambda-like polypeptide 1"	"22"	"23915312"	"23922495"	"IGLL1"	"ENSG00000128322"	"P15814"	""	""	""	""	""	""	""	"Critical for B-cell development."	""	"FALSE"
"6493-9_3"	""	"CBPZ"	"Carboxypeptidase Z"	"4"	"8594387"	"8621486"	"CPZ"	"ENSG00000109625"	"Q66K79"	""	""	""	""	""	""	""	"Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing."	""	"FALSE"
"6496-60_3"	""	"DLK1"	"Protein delta homolog 1"	"14"	"101192042"	"101204561"	"DLK1"	"ENSG00000185559"	"P80370"	""	""	""	""	""	""	""	"May have a role in neuroendocrine differentiation."	""	"FALSE"
"6506-54_3"	""	"TMEDA"	"Transmembrane emp24 domain-containing protein 10"	"14"	"75598173"	"75643334"	"TMED10"	"ENSG00000170348"	"P49755"	""	""	""	""	""	""	""	"Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1 (By similarity). In COPI vesicle-mediated retrograde transport involved in the biogenesis of COPI vesicles and vesicle coat recruitment. On Golgi membranes, acts as primary receptor for ARF1-GDP which is involved in COPI-vesicle formation. Increases coatomer-dependent GTPase-activating activity of ARFGAP2. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2LR1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent of modulation of gamma-secretase activity). As part of the presenilin-dependent gamma-secretase complex regulates gamma-cleavages of the amyloid beta A4 protein to yield amyloid-beta 40 (Abeta40). Involved in organization of the Golgi apparatus."	""	"FALSE"
"6507-16_3"	""	"NCAM2"	"Neural cell adhesion molecule 2"	"21"	"22370633"	"22915650"	"NCAM2"	"ENSG00000154654"	"O15394"	""	""	""	""	""	""	""	"May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons."	""	"FALSE"
"6510-56_3"	""	"RN128"	"E3 ubiquitin-protein ligase RNF128"	"X"	"105937024"	"106040223"	"RNF128"	"ENSG00000133135"	"Q8TEB7"	""	""	""	""	""	""	""	"E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals."	""	"FALSE"
"6512-68_3"	""	"KREM1"	"Kremen protein 1"	"22"	"29469066"	"29564321"	"KREMEN1"	"ENSG00000183762"	"Q96MU8"	""	""	""	""	""	""	""	"Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane. Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification."	""	"FALSE"
"6521-35_3"	""	"NPTX2"	"Neuronal pentraxin-2"	"7"	"98246609"	"98259180"	"NPTX2"	"ENSG00000106236"	"P47972"	""	""	""	""	""	""	""	"Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity)."	""	"FALSE"
"6522-57_3"	""	"AMBN"	"Ameloblastin"	"4"	"71457973"	"71473005"	"AMBN"	"ENSG00000178522"	"Q9NP70"	""	""	""	""	""	""	""	"Involved in the mineralization and structural organization of enamel."	""	"FALSE"
"6525-17_3"	""	"DUSP13"	"Dual specificity protein phosphatase 13 isoform A"	"10"	"76854190"	"76868979"	"DUSP13"	"ENSG00000079393"	"Q6B8I1"	""	""	""	""	""	""	""	"Probable protein tyrosine phosphatase. Has phosphatase activity with synthetic substrates (PubMed:15252030, PubMed:29106959). Has a phosphatase activity-independent regulatory role in MAP3K5/ASK1-mediated apoptosis, preventing MAP3K5/ASK1 inhibition by AKT1. Shows no phosphatase activity on MAPK1/ERK2, MAPK8/JNK, MAPK14/p38 and MAP3K5/ASK1."	""	"FALSE"
"6528-95_3"	""	"EXTL2"	"Exostosin-like 2"	"1"	"101337928"	"101361554"	"EXTL2"	"ENSG00000162694"	"Q9UBQ6"	""	""	""	""	""	""	""	"Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains."	""	"FALSE"
"6538-90_3"	""	"K2013"	"Uncharacterized protein KIAA2013"	"1"	"11979648"	"11986485"	"KIAA2013"	"ENSG00000116685"	"Q8IYS2"	""	""	""	""	""	""	""	"Membrane"	""	"FALSE"
"6544-33_3"	""	"NELL1"	"Protein kinase C-binding protein NELL1"	"11"	"20691097"	"21597227"	"NELL1"	"ENSG00000165973"	"Q92832"	""	""	""	""	""	""	""	"Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization."	""	"FALSE"
"6547-83_3"	""	"TM11D"	"Transmembrane protease serine 11D"	"4"	"68686594"	"68749750"	"TMPRSS11D"	"ENSG00000153802"	"O60235"	""	""	""	""	""	""	""	"May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate."	""	"FALSE"
"6550-4_3"	""	"ICAM4"	"Intercellular adhesion molecule 4"	"19"	"10397643"	"10399198"	"ICAM4"	"ENSG00000105371"	"Q14773"	""	""	""	""	""	""	""	"ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins."	""	"FALSE"
"6551-94_3"	""	"Vaspin"	"Serpin A12"	"14"	"94953611"	"94984181"	"SERPINA12"	"ENSG00000165953"	"Q8IW75"	""	""	""	""	""	""	""	"Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues."	""	"FALSE"
"6556-5_3"	""	"ENPP5"	"Ectonucleotide pyrophosphatase/phosphodiesterase family member 5"	"6"	"46126924"	"46138708"	"ENPP5"	"ENSG00000112796"	"Q9UJA9"	""	""	""	""	""	""	""	"Can hydrolyze NAD but cannot hydrolyze nucleotide di- and triphosphates. Lacks lysopholipase D activity. May play a role in neuronal cell communication."	""	"FALSE"
"6557-50_3"	""	"LRC15"	"Leucine-rich repeat-containing protein 15"	"3"	"194075976"	"194090472"	"LRRC15"	"ENSG00000172061"	"Q8TF66"	""	""	""	""	""	""	""	"Membrane"	""	"FALSE"
"6558-5_3"	""	"COL10"	"Collectin-10"	"8"	"120007691"	"120118821"	"COLEC10"	"ENSG00000184374"	"Q9Y6Z7"	""	""	""	""	""	""	""	"Lectin that binds to various sugars: galactose > mannose = fucose > N-acetylglucosamine > N-acetylgalactosamine (PubMed:10224141). Acts as a chemoattractant, probably involved in the regulation of cell migration (PubMed:28301481)."	""	"FALSE"
"6576-1_3"	""	"ART4"	"Ecto-ADP-ribosyltransferase 4"	"12"	"14978503"	"14996429"	"DO"	"ENSG00000111339"	"Q93070"	""	""	""	""	""	""	""	"NAD(+) + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine."	""	"FALSE"
"6577-64_3"	""	"LAMA4"	"Laminin subunit alpha-4"	"6"	"112429963"	"112576141"	"LAMA4"	"ENSG00000112769"	"Q16363"	""	""	""	""	""	""	""	"Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components."	""	"FALSE"
"6581-50_3"	""	"Gc-Globulin, Mixed Type"	"Vitamin D-binding protein"	"4"	"72607410"	"72669758"	"GC"	"ENSG00000145321"	"P02774"	""	""	""	""	""	""	""	"Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation."	""	"FALSE"
"6583-67_3"	""	"protein Z inhibitor"	"Protein Z-dependent protease inhibitor"	"14"	"94746792"	"94759608"	"SERPINA10"	"ENSG00000140093"	"Q9UK55"	""	""	""	""	""	""	""	"Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors."	""	"FALSE"
"6586-19_3"	""	"ADA11"	"Disintegrin and metalloproteinase domain-containing protein 11"	"17"	"42836399"	"42859214"	"ADAM11"	"ENSG00000073670"	"O75078"	""	""	""	""	""	""	""	"Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein."	""	"FALSE"
"6590-54_3"	""	"Neuropilin-2"	"Neuropilin-2"	"2"	"206546714"	"206662857"	"NRP2"	"ENSG00000118257"	"O60462"	""	""	""	""	""	""	""	"High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF."	""	"FALSE"
"6597-24_3"	""	"TM157"	"Membrane protein FAM174A"	"5"	"99871009"	"99922445"	"FAM174A"	"ENSG00000174132"	"Q8TBP5"	""	""	""	""	""	""	""	"Membrane"	""	"FALSE"
"6612-90_3"	""	"CP079"	"BRICHOS domain-containing protein 5"	"16"	"2259254"	"2261951"	"BRICD5"	"ENSG00000182685"	"Q6PL45"	""	""	""	""	""	""	""	"EBI-12244618"	""	"FALSE"
"6617-12_3"	""	"FCRL6"	"Fc receptor-like protein 6"	"1"	"159770301"	"159786041"	"FCRL6"	"ENSG00000181036"	"Q6DN72"	""	""	""	""	""	""	""	"Acts as a MHC class II receptor (PubMed:20519654). When stimulated on its own, does not play a role in cytokine production or the release of cytotoxic granules by NK cells and cytotoxic CD8(+) T cells (PubMed:17213291, PubMed:18991291). Does not act as an Fc receptor (PubMed:18991291)."	""	"FALSE"
"6627-25_3"	""	"LIPR1"	"Inactive pancreatic lipase-related protein 1"	"10"	"118349897"	"118368687"	"PNLIPRP1"	"ENSG00000187021"	"P54315"	""	""	""	""	""	""	""	"May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) (By similarity)."	""	"FALSE"
"6629-3_3"	""	"HBD-1"	"Beta-defensin 1"	"8"	"6728097"	"6735544"	"DEFB1"	"ENSG00000164825"	"P60022"	""	""	""	""	""	""	""	"Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:25122636)."	""	"FALSE"
"6633-43_3"	""	"UPK3L"	"Uroplakin-3b-like protein"	"7"	"102277472"	"102283238"	"UPK3BL"	"ENSG00000267368"	"B0FP48"	""	""	""	""	""	""	""	"Membrane"	""	"FALSE"
"6645-53_3"	""	"Periostin"	"Periostin"	"13"	"38136720"	"38172981"	"POSTN"	"ENSG00000133110"	"Q15063"	""	""	""	""	""	""	""	"Induces cell attachment and spreading and plays a role in cell adhesion (PubMed:12235007). Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity)."	""	"FALSE"
"6649-51_3"	""	"NET1"	"Netrin-1"	"17"	"8924859"	"9147317"	"NTN1"	"ENSG00000065320"	"O95631"	""	""	""	""	""	""	""	"Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis."	""	"FALSE"
"6650-20_3"	""	"Periostin"	"Periostin"	"13"	"38136720"	"38172981"	"POSTN"	"ENSG00000133110"	"Q15063"	""	""	""	""	""	""	""	"Induces cell attachment and spreading and plays a role in cell adhesion (PubMed:12235007). Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity)."	""	"FALSE"
"6651-74_3"	""	"PolyUbiquitin K48"	"PolyUbiquitin K48-linked"	"17"	"16284112"	"16286059"	"UBB"	"ENSG00000170315"	"P0CG47"	""	""	""	""	""	""	""	"Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling."	""	"FALSE"
"6897-38_3"	""	"B3GA3"	"Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3"	"11"	"62382768"	"62389647"	"B3GAT3"	"ENSG00000149541"	"O94766"	""	""	""	""	""	""	""	"Glycosaminoglycans biosynthesis (PubMed:25893793). Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins. Shows strict specificity for Gal-beta-1,3-Gal-beta-1,4-Xyl, exhibiting negligible incorporation into other galactoside substrates including Galbeta1-3Gal beta1-O-benzyl, Galbeta1-4GlcNAc and Galbeta1-4Glc. Stimulates 2-phosphoxylose phosphatase activity of PXYLP1 in presence of uridine diphosphate-glucuronic acid (UDP-GlcUA) during completion of linkage region formation (PubMed:24425863)."	""	"FALSE"
"6909-40_3"	""	"MGAT2"	"Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase"	"14"	"50087513"	"50090199"	"MGAT2"	"ENSG00000168282"	"Q10469"	""	""	""	""	""	""	""	"Catalyzes an essential step in the conversion of oligo-mannose to complex N-glycans."	""	"FALSE"
"6913-189_3"	""	"HMG-2"	"High mobility group protein B2"	"4"	"174252846"	"174256276"	"HMGB2"	"ENSG00000164104"	"P26583"	""	""	""	""	""	""	""	"Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:7797075, PubMed:11909973, PubMed:19522541, PubMed:18413230, PubMed:19965638, PubMed:20123072). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE (PubMed:19811285). Has antimicrobial activity in gastrointestinal epithelial tissues (PubMed:23877675). Involved in inflammatory response to antigenic stimulus coupled with proinflammatory activity (By similarity). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (By similarity). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity)."	""	"FALSE"
"6919-3_3"	""	"HBAZ"	"Hemoglobin subunit zeta"	"16"	"202686"	"204502"	"HBZ"	"ENSG00000130656"	"P02008"	""	""	""	""	""	""	""	"The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin."	""	"FALSE"
"6920-1_3"	""	"GFRAL"	"GDNF family receptor alpha-like"	"6"	"55192267"	"55267291"	"GFRAL"	"ENSG00000187871"	"Q6UXV0"	""	""	""	""	""	""	""	"Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways."	""	"FALSE"
"6936-7_3"	""	"PMEPA"	"Protein TMEPAI"	"20"	"56223448"	"56286592"	"PMEPA1"	"ENSG00000124225"	"Q969W9"	""	""	""	""	""	""	""	"Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514)."	""	"FALSE"
"6941-11_3"	""	"SUMF1"	"Sulfatase-modifying factor 1"	"3"	"3742498"	"4508965"	"SUMF1"	"ENSG00000144455"	"Q8NBK3"	""	""	""	""	""	""	""	"Oxidase that catalyzes the conversion of cysteine to 3-oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent (PubMed:12757706, PubMed:15657036, PubMed:15907468, PubMed:25931126, PubMed:16368756, PubMed:21224894). 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3-oxoalanine as a catalytic nucleophile (PubMed:12757706, PubMed:15657036, PubMed:15907468, PubMed:25931126, PubMed:16368756). Known substrates include GALNS, ARSA, STS and ARSE (PubMed:12757706, PubMed:15907468, PubMed:15657036)."	""	"FALSE"
"6947-4_3"	""	"SIA10"	"Type 2 lactosamine alpha-2,3-sialyltransferase"	"3"	"98451080"	"98540045"	"ST3GAL6"	"ENSG00000064225"	"Q9Y274"	""	""	""	""	""	""	""	"Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3-sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1."	""	"FALSE"
"6961-14_3"	""	"IGFL3"	"Insulin growth factor-like family member 3"	"19"	"46623328"	"46627931"	"IGFL3"	"ENSG00000188624"	"Q6UXB1"	""	""	""	""	""	""	""	"Potential ligand of the IGFLR1 cell membrane receptor."	""	"FALSE"
"6965-19_3"	""	"CNTP2"	"Contactin-associated protein-like 2"	"7"	"145813094"	"148118090"	"CNTNAP2"	"ENSG00000174469"	"Q9UHC6"	""	""	""	""	""	""	""	"Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the juxtaparanodal region of the axo-glial junction."	""	"FALSE"
"6991-24_3"	""	"FUT9"	"Alpha-(1,3)-fucosyltransferase 9"	"6"	"96463860"	"96663488"	"FUT9"	"ENSG00000172461"	"Q9Y231"	""	""	""	""	""	""	""	"Transfers a fucose to lacto-N-neotetraose but not to either alpha2,3-sialyl lacto-N-neotetraose or lacto-N-tetraose. Can catalyze the last step in the biosynthesis of Lewis antigen, the addition of a fucose to precursor polysaccharides."	""	"FALSE"
"6994-19_3"	""	"CC018"	"Uncharacterized protein C3orf18"	"3"	"50595456"	"50608458"	"C3orf18"	"ENSG00000088543"	"Q9UK00"	""	""	""	""	""	""	""	"Membrane"	""	"FALSE"
"6997-32_3"	""	"RAB26"	"Ras-related protein Rab-26"	"16"	"2190804"	"2204166"	"RAB26"	"ENSG00000167964"	"Q9ULW5"	""	""	""	""	""	""	""	"The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach. Plays a role in the secretion of amylase from acinar granules in the parotid gland."	""	"FALSE"
"6998-106_3"	""	"HAAH"	"Aspartyl/asparaginyl beta-hydroxylase"	"8"	"62413115"	"62627199"	"ASPH"	"ENSG00000198363"	"Q12797"	""	""	""	""	""	""	""	"Isoform 1: specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins."	""	"FALSE"
"7008-13_3"	""	"F176C"	"Protein eva-1 homolog C"	"21"	"33784314"	"33887707"	"EVA1C"	"ENSG00000166979"	"P58658"	""	""	""	""	""	""	""	"Binds heparin."	""	"FALSE"
"7014-27_3"	""	"LRC19"	"Leucine-rich repeat-containing protein 19"	"9"	"26993134"	"27005691"	"LRRC19"	"ENSG00000184434"	"Q9H756"	""	""	""	""	""	""	""	"Membrane"	""	"FALSE"
"7015-8_3"	""	"LIRB5"	"Leukocyte immunoglobulin-like receptor subfamily B member 5"	"19"	"54753289"	"54761164"	"LILRB5"	"ENSG00000105609"	"O75023"	""	""	""	""	""	""	""	"May act as receptor for class I MHC antigens."	""	"FALSE"
"7034-4_3"	""	"SGCB"	"Beta-sarcoglycan"	"4"	"52886872"	"52904648"	"SGCB"	"ENSG00000163069"	"Q16585"	""	""	""	""	""	""	""	"Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix."	""	"FALSE"
"7049-2_3"	""	"ADAM 23"	"Disintegrin and metalloproteinase domain-containing protein 23"	"2"	"207308263"	"207485854"	"ADAM23"	"ENSG00000114948"	"O75077"	""	""	""	""	""	""	""	"May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein."	""	"FALSE"
"7054-87_3"	""	"CLC2D"	"C-type lectin domain family 2 member D"	"12"	"9817565"	"9852151"	"CLEC2D"	"ENSG00000069493"	"Q9UHP7"	""	""	""	""	""	""	""	"Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis (PubMed:20843815, PubMed:16339513). Inhibits osteoclast formation (PubMed:14753741, PubMed:15123656). Inhibits bone resorption (PubMed:14753741). Modulates the release of interferon-gamma (PubMed:15104121). Binds high molecular weight sulfated glycosaminoglycans (PubMed:15123656)."	""	"FALSE"
"7057-18_3"	""	"SHSA3"	"Protein shisa-3 homolog"	"4"	"42399856"	"42404504"	"SHISA3"	"ENSG00000178343"	"A0PJX4"	""	""	""	""	""	""	""	"Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling."	""	"FALSE"
"7059-14_3"	""	"LIRA6"	"Leukocyte immunoglobulin-like receptor subfamily A member 6"	"19"	"54720737"	"54746649"	"LILRA6"	"ENSG00000244482"	"Q6PI73"	""	""	""	""	""	""	""	"May act as receptor for class I MHC antigens."	""	"FALSE"
"7060-2_3"	""	"ERO1A"	"ERO1-like protein alpha"	"14"	"53106634"	"53162618"	"ERO1L"	"ENSG00000197930"	"Q96HE7"	""	""	""	""	""	""	""	"Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1."	""	"FALSE"
"7069-9_4"	""	"TSNA1"	"t-SNARE domain-containing protein 1"	"8"	"143293441"	"143484601"	"TSNARE1"	"ENSG00000171045"	"Q96NA8"	""	""	""	""	""	""	""	"Membrane"	""	"FALSE"
"7071-23_4"	""	"MA1B1"	"Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase"	"9"	"139981379"	"140003639"	"MAN1B1"	"ENSG00000177239"	"Q9UKM7"	""	""	""	""	""	""	""	"Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2)."	""	"FALSE"
"7077-9_4"	""	"CLC4E"	"C-type lectin domain family 4 member E"	"12"	"8685901"	"8693559"	"CLEC4E"	"ENSG00000166523"	"Q9ULY5"	""	""	""	""	""	""	""	"C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B."	""	"FALSE"
"7083-74_3"	""	"MATN4"	"Matrilin-4"	"20"	"43922085"	"43937169"	"MATN4"	"ENSG00000124159"	"O95460"	""	""	""	""	""	""	""	"Major component of the extracellular matrix of cartilage."	""	"FALSE"
"7085-81_3"	""	"CDSN"	"Corneodesmosin"	"6"	"31075367"	"31080724"	"CDSN"	"ENSG00000137197"	"Q15517"	""	""	""	""	""	""	""	"Important for the epidermal barrier integrity."	""	"FALSE"
"7089-42_3"	""	"SYT11"	"Synaptotagmin-11"	"1"	"155829300"	"155854990"	"SYT11"	"ENSG00000132718"	"Q9BT88"	""	""	""	""	""	""	""	"May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis."	""	"FALSE"
"7090-17_3"	""	"GALT1"	"Polypeptide N-acetylgalactosaminyltransferase 1"	"18"	"33161081"	"33291798"	"GALNT1"	"ENSG00000141429"	"Q10472"	""	""	""	""	""	""	""	"Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b and Muc7."	""	"FALSE"
"7093-20_3"	""	"NRX3B"	"Neurexin-3-beta"	"14"	"78708734"	"80334633"	"NRXN3"	"ENSG00000021645"	"Q9HDB5"	""	""	""	""	""	""	""	"Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May play a role in angiogenesis (By similarity)."	""	"FALSE"
"7096-30_3"	""	"RMD1"	"Regulator of microtubule dynamics protein 1"	"8"	"87480486"	"87526586"	"RMDN1"	"ENSG00000176623"	"Q96DB5"	""	""	""	""	""	""	""	"Interacts with microtubules."	""	"FALSE"
"7097-8_3"	""	"CDY1"	"Testis-specific chromodomain protein Y 1"	"Y|Y"	"27768309|26191376"	"27771049|26194166"	"CDY1|CDY1"	"ENSG00000172288|ENSG00000172352"	"Q9Y6F8|Q9Y6F8"	""	""	""	""	""	""	""	"Has histone acetyltransferase activity, with a preference for histone H4."	""	"FALSE"
"7110-2_3"	""	"DJB11"	"DnaJ homolog subfamily B member 11"	"3"	"186285192"	"186314992"	"DNAJB11"	"ENSG00000090520"	"Q9UBS4"	""	""	""	""	""	""	""	"Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity."	""	"FALSE"
"7115-5_3"	""	"Semenogelin"	"Semenogelin-1"	"20"	"43835638"	"43838413"	"SEMG1"	"ENSG00000124233"	"P04279"	""	""	""	""	""	""	""	"Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA."	""	"FALSE"
"7124-18_3"	""	"IL-21"	"Interleukin-21"	"4"	"123533783"	"123542224"	"IL21"	"ENSG00000138684"	"Q9HBE4"	""	""	""	""	""	""	""	"Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation."	""	"FALSE"
"7141-21_3"	""	"MGT4B"	"Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B"	"5"	"179224597"	"179233952"	"MGAT4B"	"ENSG00000161013"	"Q9UQ53"	""	""	""	""	""	""	""	"Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Has lower affinities for donors or acceptors than MGAT4A, suggesting that, under physiological conditions, it is not the main contributor in N-glycan biosynthesis."	""	"FALSE"
"7152-5_3"	""	"TIMD3"	"Hepatitis A virus cellular receptor 2"	"5"	"156512843"	"156569880"	"HAVCR2"	"ENSG00000135077"	"Q8TDQ0"	""	""	""	""	""	""	""	"Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand (PubMed:24825777). Regulates macrophage activation (PubMed:11823861). Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance (PubMed:14556005). In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion. The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits, and/or LGALS9-dependent recruitment of PTPRC to the immunological synapse (PubMed:24337741, PubMed:26492563). In contrast, shown to activate TCR-induced signaling in T-cells probably implicating ZAP70, LCP2, LCK and FYN (By similarity). Expressed on Treg cells can inhibit Th17 cell responses (PubMed:24838857). Receptor for LGALS9 (PubMed:16286920, PubMed:24337741). Binding to LGALS9 is believed to result in suppression of T-cell responses; the resulting apoptosis of antigen-specific cells may implicate HAVCR2 phosphorylation and disruption of its association with BAG6. Binding to LGALS9 is proposed to be involved in innate immune response to intracellular pathogens. Expressed on Th1 cells interacts with LGALS9 expressed on Mycobacterium tuberculosis-infected macrophages to stimulate antibactericidal activity including IL-1 beta secretion and to restrict intracellular bacterial growth (By similarity). However, the function as receptor for LGALS9 has been challenged (PubMed:23555261). Also reported to enhance CD8+ T-cell responses to an acute infection such as by Listeria monocytogenes (By similarity). Receptor for phosphatidylserine (PtSer); PtSer-binding is calcium-dependent. May recognize PtSer on apoptotic cells leading to their phagocytosis. Mediates the engulfment of apoptotic cells by dendritic cells. Expressed on T-cells, promotes conjugation but not engulfment of apoptotic cells. Expressed on dendritic cells (DCs) positively regulates innate immune response and in synergy with Toll-like receptors promotes secretion of TNF-alpha. In tumor-imfiltrating DCs suppresses nucleic acid-mediated innate immune repsonse by interaction with HMGB1 and interfering with nucleic acid-sensing and trafficking of nucleid acids to endosomes (By similarity). Expressed on natural killer (NK) cells acts as a coreceptor to enhance IFN-gamma production in response to LGALS9 (PubMed:22323453). In contrast, shown to suppress NK cell-mediated cytotoxicity (PubMed:22383801). Negatively regulates NK cell function in LPS-induced endotoxic shock (By similarity)."	""	"FALSE"
"7156-2_3"	""	"FUT10"	"Alpha-(1,3)-fucosyltransferase 10"	"8"	"33228342"	"33330940"	"FUT10"	"ENSG00000172728"	"Q6P4F1"	""	""	""	""	""	""	""	"Probable fucosyltransferase."	""	"FALSE"
"7157-22_3"	""	"PCDA4"	"Protocadherin alpha-4"	"5"	"140186514"	"140391929"	"PCDHA4"	"ENSG00000204967"	"Q9UN74"	""	""	""	""	""	""	""	"Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain."	""	"FALSE"
"7161-25_3"	""	"G6PE"	"GDH/6PGL endoplasmic bifunctional protein"	"1"	"9294834"	"9331396"	"H6PD"	"ENSG00000049239"	"O95479"	""	""	""	""	""	""	""	"Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates."	""	"FALSE"
"7167-102_3"	""	"VAPA"	"Vesicle-associated membrane protein-associated protein A"	"18"	"9913999"	"9960018"	"VAPA"	"ENSG00000101558"	"Q9P0L0"	""	""	""	""	""	""	""	"Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:25447204). With OSBPL3, may regulate ER morphology (PubMed:16143324). May play a role in vesicle trafficking (PubMed:11511104, PubMed:19289470)."	""	"FALSE"
"7173-141_3"	""	"T132C"	"Transmembrane protein 132C"	"12"	"128751948"	"129192460"	"TMEM132C"	"ENSG00000181234"	"Q8N3T6"	""	""	""	""	""	""	""	"Membrane"	""	"FALSE"
"7178-59_3"	""	"DEPP"	"Protein DEPP"	"10"	"45466429"	"45474258"	"DEPP"	"ENSG00000165507"	"Q9NTK1"	""	""	""	""	""	""	""	"Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS."	""	"FALSE"
"7179-69_3"	""	"NFASC"	"Neurofascin"	"1"	"204797779"	"204991950"	"NFASC"	"ENSG00000163531"	"O94856"	""	""	""	""	""	""	""	"Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions."	""	"FALSE"
"7198-197_3"	""	"FA20B"	"Glycosaminoglycan xylosylkinase"	"1"	"178994939"	"179045697"	"FAM20B"	"ENSG00000116199"	"O75063"	""	""	""	""	""	""	""	"Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-phosphorylation may influence the catalytic activity of B3GAT3 (GlcAT-I) which completes the precursor tetrasaccharide of GAG-protein linkage regions on which the repeating disaccharide region is synthesized."	""	"FALSE"
"7203-125_3"	""	"RFNG"	"Beta-1,3-N-acetylglucosaminyltransferase radical fringe"	"17"	"80005778"	"80009707"	"RFNG"	"ENSG00000169733"	"Q9Y644"	""	""	""	""	""	""	""	"Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in enhancement of NOTCH1 activation by DLL1 and JAG1. May be involved in limb formation and in neurogenesis."	""	"FALSE"
"7206-20_3"	""	"F16P1"	"Fructose-1,6-bisphosphatase 1"	"9"	"97365415"	"97402531"	"FBP1"	"ENSG00000165140"	"P09467"	""	""	""	""	""	""	""	"Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain."	""	"FALSE"
"7211-2_3"	""	"RNase 1"	"Ribonuclease pancreatic"	"14"	"21269387"	"21271437"	"RNASE1"	"ENSG00000129538"	"P07998"	""	""	""	""	""	""	""	"Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA."	""	"FALSE"
"7218-87_3"	""	"AT1B2"	"Sodium/potassium-transporting ATPase subunit beta-2"	"17"	"7549945"	"7561086"	"ATP1B2"	"ENSG00000129244"	"P14415"	""	""	""	""	""	""	""	"This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known."	""	"FALSE"
"7223-60_3"	""	"S100A13"	"Protein S100-A13"	"1"	"153591263"	"153606568"	"S100A13"	"ENSG00000189171"	"Q99584"	""	""	""	""	""	""	""	"Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity)."	""	"FALSE"
"7227-75_3"	""	"COCH"	"Cochlin"	"14"	"31343720"	"31364271"	"COCH"	"ENSG00000100473"	"O43405"	""	""	""	""	""	""	""	"Plays a role in the control of cell shape and motility in the trabecular meshwork."	""	"FALSE"
"7239-9_3"	""	"GST M1-1"	"Glutathione S-transferase Mu 1"	"1"	"110230436"	"110251661"	"GSTM1"	"ENSG00000134184"	"P09488"	""	""	""	""	""	""	""	"Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles."	""	"FALSE"
"7244-16_3"	""	"TM149"	"IGF-like family receptor 1"	"19"	"36229702"	"36233354"	"IGFLR1"	"ENSG00000126246"	"Q9H665"	""	""	""	""	""	""	""	"Probable cell membrane receptor for the IGF-like family proteins. Binds IGFL1 and IGFL3 with a higher affinity. May also bind IGFL2."	""	"FALSE"
"7247-1_3"	""	"GORAB"	"RAB6-interacting golgin"	"1"	"170501270"	"170522587"	"GORAB"	"ENSG00000120370"	"Q5T7V8"	""	""	""	""	""	""	""	"Interacts with SCYL1 (By similarity). Interacts with RCHY1 and RAB6A/RAB6."	""	"FALSE"
"7257-18_3"	""	"TIP39"	"Tuberoinfundibular peptide of 39 residues"	"19"	"49925671"	"49926698"	"PTH2"	"ENSG00000142538"	"Q96A98"	""	""	""	""	""	""	""	"Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action on PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits."	""	"FALSE"
"7266-4_3"	""	"SPA9"	"Serpin A9"	"14"	"94929054"	"94946026"	"SERPINA9"	"ENSG00000170054"	"Q86WD7"	""	""	""	""	""	""	""	"Protease inhibitor that inhibits trypsin and trypsin-like serine proteases (in vitro). Inhibits plasmin and thrombin with lower efficiency (in vitro)."	""	"FALSE"
"7624-19_3"	""	"ANK2"	"Ankyrin-2"	"4"	"113739265"	"114304896"	"ANK2"	"ENSG00000145362"	"Q01484"	""	""	""	""	""	""	""	"In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. Attaches integral membrane proteins to cytoskeletal elements. Also binds to cytoskeletal proteins. Required for coordinate assembly of Na/Ca exchanger, Na/K ATPase and InsP3 receptor at sarcoplasmic reticulum sites in cardiomyocytes. Required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) in the inner segment of rod photoreceptors (By similarity). Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity)."	""	"FALSE"
"7628-40_3"	""	"CREL1"	"Cysteine-rich with EGF-like domain protein 1"	"3"	"9975506"	"9987097"	"CRELD1"	"ENSG00000163703"	"Q96HD1"	""	""	""	""	""	""	""	"Membrane"	""	"FALSE"
"7640-29_3"	""	"LRP1B"	"Low-density lipoprotein receptor-related protein 1B"	"2"	"140988992"	"142889270"	"LRP1B"	"ENSG00000168702"	"Q9NZR2"	""	""	""	""	""	""	""	"Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis."	""	"FALSE"
"7655-11_3"	""	"N-terminal pro-BNP"	"N-terminal pro-BNP"	"1"	"11917521"	"11918988"	"NPPB"	"ENSG00000120937"	"P16860"	""	""	""	""	""	""	""	"Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3."	""	"FALSE"
"7696-104_3"	""	"NBR1"	"Next to BRCA1 gene 1 protein"	"17"	"41322498"	"41363708"	"NBR1"	"ENSG00000188554"	"Q14596"	""	""	""	""	""	""	""	"Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets."	""	"FALSE"
"7735-17_3"	""	"PEDF"	"Pigment epithelium-derived factor"	"17"	"1665253"	"1680868"	"SERPINF1"	"ENSG00000132386"	"P36955"	""	""	""	""	""	""	""	"Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity."	""	"FALSE"
"7736-28_3"	""	"OPALI"	"Opalin"	"10"	"98102973"	"98119122"	"OPALIN"	"ENSG00000197430"	"Q96PE5"	""	""	""	""	""	""	""	"Cell membrane"	""	"FALSE"
"7738-299_3"	""	"STX2"	"Syntaxin-2"	"12"	"131274145"	"131323811"	"STX2"	"ENSG00000111450"	"P32856"	""	""	""	""	""	""	""	"Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm."	""	"FALSE"
"7745-3_3"	""	"ZCD1"	"CDGSH iron-sulfur domain-containing protein 1"	"10"	"60028818"	"60049346"	"CISD1"	"ENSG00000122873"	"Q9NZ45"	""	""	""	""	""	""	""	"Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation (By similarity). May be involved in Fe-S cluster shuttling and/or in redox reactions."	""	"FALSE"
"7746-230_3"	""	"NCAM1"	"Neural cell adhesion molecule 1"	"11"	"112831969"	"113149158"	"NCAM1"	"ENSG00000149294"	"P13591"	""	""	""	""	""	""	""	"This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc."	""	"FALSE"
"7751-121_3"	""	"SARP-1"	"Secreted frizzled-related protein 2"	"4"	"154701744"	"154710272"	"SFRP2"	"ENSG00000145423"	"Q96HF1"	""	""	""	""	""	""	""	"Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis."	""	"FALSE"
"7753-21_3"	""	"HTAI2"	"Oxidoreductase HTATIP2"	"11"	"20385231"	"20405329"	"HTATIP2"	"ENSG00000109854"	"Q9BUP3"	""	""	""	""	""	""	""	"Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect."	""	"FALSE"
"7756-37_3"	""	"KLRF1"	"Killer cell lectin-like receptor subfamily F member 1"	"12"	"9980077"	"9997606"	"KLRF1"	"ENSG00000150045"	"Q9NZS2"	""	""	""	""	""	""	""	"Involved in the natural killer (NK)-mediated cytolysis of PHA-induced lymphoblasts."	""	"FALSE"
"7757-5_3"	""	"DQA2"	"HLA class II histocompatibility antigen, DQ alpha 2 chain"	"6"	"32709119"	"32714992"	"HLA-DQA2"	"ENSG00000237541"	"P01906"	""	""	""	""	""	""	""	"Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading."	""	"FALSE"
"7765-15_3"	""	"ITM2A"	"Integral membrane protein 2A"	"X"	"78615881"	"78623164"	"ITM2A"	"ENSG00000078596"	"O43736"	""	""	""	""	""	""	""	"EBI-2431769"	""	"FALSE"
"7766-25_3"	""	"ZP4"	"Zona pellucida sperm-binding protein 4"	"1"	"238041164"	"238054222"	"ZP4"	"ENSG00000116996"	"Q12836"	""	""	""	""	""	""	""	"The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor."	""	"FALSE"
"7768-10_3"	""	"CBPM"	"Carboxypeptidase M"	"12"	"69235977"	"69365350"	"CPM"	"ENSG00000135678"	"P14384"	""	""	""	""	""	""	""	"Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins."	""	"FALSE"
"7769-29_3"	""	"3BP2"	"SH3 domain-binding protein 2"	"4"	"2794750"	"2842825"	"SH3BP2"	"ENSG00000087266"	"P78314"	""	""	""	""	""	""	""	"Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism."	""	"FALSE"
"7773-20_3"	""	"KI2L2"	"Killer cell immunoglobulin-like receptor 2DL2"	"19"	"21890"	"36439"	"KIR2DL2"	"ENSG00000278731"	"P43627"	""	""	""	""	""	""	""	"Receptor on natural killer (NK) cells for HLA-Cw1, 3, 7, and 8 allotypes. Inhibits the activity of NK cells thus preventing cell lysis."	""	"FALSE"
"7778-104_3"	""	"BINCA"	"Bcl10-interacting CARD protein"	"9"	"95858500"	"95875565"	"C9ORF89"	"ENSG00000165233"	"Q96LW7"	""	""	""	""	""	""	""	"Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner."	""	"FALSE"
"7779-86_3"	""	"CHSTB"	"Carbohydrate sulfotransferase 11"	"12"	"104849073"	"105155792"	"CHST11"	"ENSG00000171310"	"Q9NPF2"	""	""	""	""	""	""	""	"Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor."	""	"FALSE"
"7785-1_3"	""	"Ephrin-B3"	"Ephrin-B3"	"17"	"7608520"	"7614696"	"EFNB3"	"ENSG00000108947"	"Q15768"	""	""	""	""	""	""	""	"Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity)."	""	"FALSE"
"7787-25_3"	""	"LIRA5"	"Leukocyte immunoglobulin-like receptor subfamily A member 5"	"19"	"54818353"	"54824409"	"LILRA5"	"ENSG00000187116"	"A6NI73"	""	""	""	""	""	""	""	"May play a role in triggering innate immune responses. Does not seem to play a role for any class I MHC antigen recognition."	""	"FALSE"
"7790-21_3"	""	"LIF"	"Leukemia inhibitory factor"	"22"	"30636436"	"30642840"	"LIF"	"ENSG00000128342"	"P15018"	""	""	""	""	""	""	""	"LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes."	""	"FALSE"
"7795-14_3"	""	"NKG2E"	"NKG2-E type II integral membrane protein"	"12"	"10564911"	"10573194"	"KLRC3"	"ENSG00000205810"	"Q07444"	""	""	""	""	""	""	""	"Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells."	""	"FALSE"
"7796-10_3"	""	"CD79A"	"B-cell antigen receptor complex-associated protein alpha chain"	"19"	"42381190"	"42385439"	"CD79A"	"ENSG00000105369"	"P11912"	""	""	""	""	""	""	""	"Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells."	""	"FALSE"
"7799-3_3"	""	"KI2LA"	"Killer cell immunoglobulin-like receptor 2DL5A"	"19"	"86691"	"96155"	"KIR2DL5A"	"ENSG00000274676"	"Q8N109"	""	""	""	""	""	""	""	"Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis."	""	"FALSE"
"7800-85_3"	""	"N2DL4"	"NKG2D ligand 4"	"6"	"150204511"	"150219238"	"RAET1E"	"ENSG00000164520"	"Q8TD07"	""	""	""	""	""	""	""	"Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity."	""	"FALSE"
"7803-4_3"	""	"CHST1"	"Carbohydrate sulfotransferase 1"	"11"	"45670427"	"45687172"	"CHST1"	"ENSG00000175264"	"O43916"	""	""	""	""	""	""	""	"Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of galactose (Gal) residues of keratan. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc structures is much higher than the corresponding desialylated substrate, and only internal Gal residues are sulfated. May function in the sulfation of sialyl N-acetyllactosamine oligosaccharide chains attached to glycoproteins. Participates in biosynthesis of selectin ligands. Selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation."	""	"FALSE"
"7805-52_3"	""	"GOS-28"	"Golgi SNAP receptor complex member 1"	"17"	"28804380"	"28854610"	"GOSR1"	"ENSG00000108587"	"O95249"	""	""	""	""	""	""	""	"Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi."	""	"FALSE"
"7808-5_3"	""	"GLCE"	"D-glucuronyl C5-epimerase"	"15"	"69452923"	"69564556"	"GLCE"	"ENSG00000138604"	"O94923"	""	""	""	""	""	""	""	"Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins."	""	"FALSE"
"7810-20_3"	""	"C1QTNF5"	"Complement C1q tumor necrosis factor-related protein 5"	"11"	"119209652"	"119211593"	"C1QTNF5"	"ENSG00000223953"	"Q9BXJ0"	""	""	""	""	""	""	""	"May interact with ERFE (By similarity). Homotrimer (via collagen-like domain). May form higher order oligomers by supercoiling of the trimers."	""	"FALSE"
"7817-36_3"	""	"CCNC"	"Cyclin-C"	"6"	"99990256"	"100016849"	"CCNC"	"ENSG00000112237"	"P24863"	""	""	""	""	""	""	""	"Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex."	""	"FALSE"
"7818-101_3"	""	"GBP6"	"Guanylate-binding protein 6"	"1"	"89829617"	"89852020"	"GBP6"	"ENSG00000183347"	"Q6ZN66"	""	""	""	""	""	""	""	"Binds GTP, GDP and GMP."	""	"FALSE"
"7823-22_3"	""	"SIA7B"	"Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2"	"17"	"74559792"	"74583038"	"ST6GALNAC2"	"ENSG00000070731"	"Q9UJ37"	""	""	""	""	""	""	""	"Catalyzes the transfer of N-acetylneuraminyl groups onto glycan chains in glycoproteins."	""	"FALSE"
"7838-27_3"	""	"SMR3A"	"Submaxillary gland androgen-regulated protein 3A"	"4"	"71226478"	"71232875"	"SMR3A"	"ENSG00000109208"	"Q99954"	""	""	""	""	""	""	""	"May play a role in protection or detoxification."	""	"FALSE"
"7841-84_3"	""	"ESAM"	"Endothelial cell-selective adhesion molecule"	"11"	"124622479"	"124632186"	"ESAM"	"ENSG00000149564"	"Q96AP7"	""	""	""	""	""	""	""	"Can mediate aggregation most likely through a homophilic molecular interaction."	""	"FALSE"
"7850-1_3"	""	"COX42"	"Cytochrome c oxidase subunit 4 isoform 2, mitochondrial"	"20"	"30225691"	"30232809"	"COX4I2"	"ENSG00000131055"	"Q96KJ9"	""	""	""	""	""	""	""	"This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport."	""	"FALSE"
"7856-51_3"	""	"F151A"	"Protein FAM151A"	"1"	"55074855"	"55089229"	"FAM151A"	"ENSG00000162391"	"Q8WW52"	""	""	""	""	""	""	""	"Membrane"	""	"FALSE"
"7864-3_3"	""	"SIGL8"	"Sialic acid-binding Ig-like lectin 8"	"19"	"51954101"	"51961710"	"SIGLEC8"	"ENSG00000105366"	"Q9NYZ4"	""	""	""	""	""	""	""	"Putative adhesion molecule that mediates sialic-acid dependent binding to red blood cells (PubMed:10856141, PubMed:10625619). Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface (PubMed:10625619). Recognizes simultaneously epitopes having a terminal N-acetylneuraminic acid (sialic acid) and an underlying 6-O-sulfated galactose. Preferentially binds to Gal-6-sulfated sialyl-Lewis X glycan epitopes (PubMed:27357658)."	""	"FALSE"
"7866-11_3"	""	"DJC30"	"DnaJ homolog subfamily C member 30"	"7"	"73095299"	"73097783"	"DNAJC30"	"ENSG00000176410"	"Q96LL9"	""	""	""	""	""	""	""	"Expressed in brain, heart, kidney, liver, lung, spleen, stomach and testis."	""	"FALSE"
"7867-154_3"	""	"SIA7A"	"Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1"	"17"	"74620843"	"74639920"	"ST6GALNAC1"	"ENSG00000070526"	"Q9NSC7"	""	""	""	""	""	""	""	"CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-((2->6)-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein."	""	"FALSE"
"7871-16_3"	""	"T132A"	"Transmembrane protein 132A"	"11"	"60691935"	"60704631"	"TMEM132A"	"ENSG00000006118"	"Q24JP5"	""	""	""	""	""	""	""	"May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation (By similarity)."	""	"FALSE"
"7880-9_3"	""	"PSA1"	"Proteasome subunit alpha type-1"	"11"	"14526420"	"14665181"	"PSMA1"	"ENSG00000129084"	"P25786"	""	""	""	""	""	""	""	"Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)."	""	"FALSE"
"7881-244_3"	""	"PAR16"	"Mono [ADP-ribose] polymerase PARP16"	"15"	"65526798"	"65592956"	"PARP16"	"ENSG00000138617"	"Q8N5Y8"	""	""	""	""	""	""	""	"Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes (PubMed:23103912, PubMed:22701565). May play a role in the unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors (PubMed:23103912). May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor (PubMed:22701565). May not modify proteins on arginine, cysteine or glutamate residues compared to other mono-ADP-ribosyltransferases (PubMed:22701565)."	""	"FALSE"
"7882-31_3"	""	"SLAF7"	"SLAM family member 7"	"1"	"160708847"	"160724611"	"SLAMF7"	"ENSG00000026751"	"Q9NQ25"	""	""	""	""	""	""	""	"Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528)."	""	"FALSE"
"7885-17_3"	""	"complement factor H-related 5"	"Complement factor H-related protein 5"	"1"	"196946686"	"196978804"	"CFHR5"	"ENSG00000134389"	"Q9BXR6"	""	""	""	""	""	""	""	"Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH."	""	"FALSE"
"7888-58_3"	""	"CCD56"	"Cytochrome c oxidase assembly factor 3 homolog, mitochondrial"	"17"	"40947165"	"40950722"	"COA3"	"ENSG00000183978"	"Q9Y2R0"	""	""	""	""	""	""	""	"Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly."	""	"FALSE"
"7891-45_3"	""	"UGT 1A6"	"UDP-glucuronosyltransferase 1-6"	"2"	"234600253"	"234681946"	"UGT1A6"	"ENSG00000167165"	"P19224"	""	""	""	""	""	""	""	"UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 3 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity)."	""	"FALSE"
"7918-114_3"	""	"Amylase, alpha 1A"	"Alpha-amylase 1"	"1|1|1"	"104197912|104230037|104293028"	"104207176|104239302|104301312"	"AMY1A|AMY1A|AMY1A"	"ENSG00000237763|ENSG00000174876|ENSG00000187733"	"P04745|P04745|P04745"	""	""	""	""	""	""	""	"Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units."	""	"FALSE"
"7921-65_3"	""	"FJX1"	"Four-jointed box protein 1"	"11"	"35639967"	"35642416"	"FJX1"	"ENSG00000179431"	"Q86VR8"	""	""	""	""	""	""	""	"Acts as an inhibitor of dendrite extension and branching."	""	"FALSE"
"7926-13_3"	""	"SPIT3"	"Kunitz-type protease inhibitor 3"	"20"	"44141101"	"44144264"	"SPINT3"	"ENSG00000101446"	"P49223"	""	""	""	""	""	""	""	"Secreted"	""	"FALSE"
"7928-183_3"	""	"TPST1"	"Protein-tyrosine sulfotransferase 1"	"7"	"65670186"	"65885530"	"TPST1"	"ENSG00000169902"	"O60507"	""	""	""	""	""	""	""	"Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate."	""	"FALSE"
"7934-11_3"	""	"NDRG4"	"Protein NDRG4"	"16"	"58496750"	"58547532"	"NDRG4"	"ENSG00000103034"	"Q9ULP0"	""	""	""	""	""	""	""	"Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress (By similarity). May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner."	""	"FALSE"
"7943-16_3"	""	"CUZD1"	"CUB and zona pellucida-like domain-containing protein 1"	"10"	"124591665"	"124610309"	"CUZD1"	"ENSG00000138161"	"Q86UP6"	""	""	""	""	""	""	""	"CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may be involved in these processes. May also play a role in the uterus during late pregnancy and/or in trypsin activation in pancreatic acinar cells."	""	"FALSE"
"7945-10_3"	""	"Semaphorin-6A"	"Semaphorin-6A"	"5"	"115779312"	"115910630"	"SEMA6A"	"ENSG00000092421"	"Q9H2E6"	""	""	""	""	""	""	""	"Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation (By similarity)."	""	"FALSE"
"7947-19_3"	""	"AP4AT"	"AP-4 complex accessory subunit tepsin"	"17"	"79202077"	"79212891"	"ENTHD2"	"ENSG00000167302"	"Q96N21"	""	""	""	""	""	""	""	"Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network."	""	"FALSE"
"7948-129_3"	""	"GLTD2"	"Glycolipid transfer protein domain-containing protein 2"	"17"	"4692254"	"4693685"	"GLTPD2"	"ENSG00000182327"	"A6NH11"	""	""	""	""	""	""	""	"Belongs to the GLTP family."	""	"FALSE"
"7955-195_3"	""	"ITI heavy chain H1"	"Inter-alpha-trypsin inhibitor heavy chain H1"	"3"	"52811608"	"52826084"	"ITIH1"	"ENSG00000055957"	"P19827"	""	""	""	""	""	""	""	"May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes."	""	"FALSE"
"7956-11_3"	""	"MOS1"	"MICOS complex subunit MIC10"	"1"	"19923471"	"19956315"	"MINOS1"	"ENSG00000173436"	"Q5TGZ0"	""	""	""	""	""	""	""	"Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane."	""	"FALSE"
"7957-2_3"	""	"SCG3"	"Secretogranin-3"	"15"	"51973550"	"52013228"	"SCG3"	"ENSG00000104112"	"Q8WXD2"	""	""	""	""	""	""	""	"Interacts with CHGA."	""	"FALSE"
"7959-34_3"	""	"CADH7"	"Cadherin-7"	"18"	"63417488"	"63557577"	"CDH7"	"ENSG00000081138"	"Q9ULB5"	""	""	""	""	""	""	""	"Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types."	""	"FALSE"
"7965-25_3"	""	"HBAT"	"Hemoglobin subunit theta-1"	"16"	"230452"	"231180"	"HBQ1"	"ENSG00000086506"	"P09105"	""	""	""	""	""	""	""	"EBI-10193656"	""	"FALSE"
"7970-315_3"	""	"NAR3"	"Ecto-ADP-ribosyltransferase 3"	"4"	"76932337"	"77033955"	"ART3"	"ENSG00000156219"	"Q13508"	""	""	""	""	""	""	""	"NAD(+) + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine."	""	"FALSE"
"7980-72_3"	""	"B3GN2"	"N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2"	"2"	"62423248"	"62451866"	"B3GNT2"	"ENSG00000170340"	"Q9NY97"	""	""	""	""	""	""	""	"Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Shows a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors (PubMed:9892646). Probably constitutes the main polylactosamine synthase."	""	"FALSE"
"7983-1_3"	""	"PCDGM"	"Protocadherin gamma-C5"	"5"	"140868688"	"140892546"	"PCDHGC5"	"ENSG00000240764"	"Q9Y5F6"	""	""	""	""	""	""	""	"Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain."	""	"FALSE"
"7986-98_3"	""	"NALD2"	"N-acetylated-alpha-linked acidic dipeptidase 2"	"11"	"89864683"	"89926062"	"NAALAD2"	"ENSG00000077616"	"Q9Y3Q0"	""	""	""	""	""	""	""	"Has N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Also exhibits a dipeptidyl-peptidase IV type activity. Inactivate the peptide neurotransmitter N-acetylaspartylglutamate."	""	"FALSE"
"7992-3_3"	""	"TMIE"	"Transmembrane inner ear expressed protein"	"3"	"46742823"	"46752376"	"TMIE"	"ENSG00000181585"	"Q8NEW7"	""	""	""	""	""	""	""	"Unknown. The protein may play some role in a cellular membrane location. May reside within an internal membrane compartment and function in pathways such as those involved in protein and/or vesicle trafficking. Alternatively, the mature protein may be localized in the plasma membrane and serve as a site of interaction for other molecules through its highly charged C-terminal domain."	""	"FALSE"
"7994-41_3"	""	"ERO1B"	"ERO1-like protein beta"	"1"	"236378855"	"236445285"	"ERO1LB"	"ENSG00000086619"	"Q86YB8"	""	""	""	""	""	""	""	"Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2 (50% of P4HB reoxidation rate), as well as PDIA3, PDIA4, PDIA6 and NXNDC12 (<10%). Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. May be involved in oxidative proinsulin folding in pancreatic cells, hence may play a role in glucose homeostasis."	""	"FALSE"
"7999-23_3"	""	"CD39"	"Ectonucleoside triphosphate diphosphohydrolase 1"	"10"	"97471536"	"97637023"	"ENTPD1"	"ENSG00000138185"	"P49961"	""	""	""	""	""	""	""	"In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well."	""	"FALSE"
"8000-17_3"	""	"KI2LA"	"Killer cell immunoglobulin-like receptor 2DL5A"	"19"	"86691"	"96155"	"KIR2DL5A"	"ENSG00000274676"	"Q8N109"	""	""	""	""	""	""	""	"Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis."	""	"FALSE"
"8005-1_3"	""	"MXRA7"	"Matrix-remodeling-associated protein 7"	"17"	"74668633"	"74707098"	"MXRA7"	"ENSG00000182534"	"P84157"	""	""	""	""	""	""	""	"Membrane"	""	"FALSE"
"8009-121_3"	""	"SURF1"	"Surfeit locus protein 1"	"9"	"136218610"	"136223552"	"SURF1"	"ENSG00000148290"	"Q15526"	""	""	""	""	""	""	""	"Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly."	""	"FALSE"
"8013-9_3"	""	"LMA2L"	"VIP36-like protein"	"2"	"97371666"	"97405801"	"LMAN2L"	"ENSG00000114988"	"Q9H0V9"	""	""	""	""	""	""	""	"May be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. May function as a regulator of ERGIC-53."	""	"FALSE"
"8014-359_3"	""	"MANEA"	"Glycoprotein endo-alpha-1,2-mannosidase"	"6"	"96025419"	"96057333"	"MANEA"	"ENSG00000172469"	"Q5SRI9"	""	""	""	""	""	""	""	"GlcMan(9)GlcNAc(2)-[protein] + H(2)O = Man(8)GlcNAc(2)-[protein] (isomer 8A(1,2,3)B(1,2)) + alpha-D-glucosyl-(1->3)-alpha-D-mannopyranose."	""	"FALSE"
"8018-43_3"	""	"VSIG2"	"V-set and immunoglobulin domain-containing protein 2"	"11"	"124617368"	"124622134"	"VSIG2"	"ENSG00000019102"	"Q96IQ7"	""	""	""	""	""	""	""	"Membrane"	""	"FALSE"
"8019-73_3"	""	"STMN3"	"Stathmin-3"	"20"	"62271058"	"62284780"	"STMN3"	"ENSG00000197457"	"Q9NZ72"	""	""	""	""	""	""	""	"Exhibits microtubule-destabilizing activity, which is antagonized by STAT3."	""	"FALSE"
"8024-64_3"	""	"TPST2"	"Protein-tyrosine sulfotransferase 2"	"22"	"26917949"	"26992681"	"TPST2"	"ENSG00000128294"	"O60704"	""	""	""	""	""	""	""	"Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate."	""	"FALSE"
"8031-11_3"	""	"CEACAM1"	"Carcinoembryonic antigen-related cell adhesion molecule 1"	"19"	"43011456"	"43065386"	"CEACAM1"	"ENSG00000079385"	"P13688"	""	""	""	""	""	""	""	"Isoform 1: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Plays a role as coinhibitory receptor in immune response, insulin action and functions also as an activator during angiogenesis (PubMed:18424730, PubMed:23696226, PubMed:25363763). Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors. Plays a role in immune response, of T cells, natural killer (NK) and neutrophils (PubMed:18424730, PubMed:23696226). Upon TCR/CD3 complex stimulation, inhibits TCR-mediated cytotoxicity by blocking granule exocytosis by mediating homophilic binding to adjacent cells, allowing interaction with and phosphorylation by LCK and interaction with the TCR/CD3 complex which recruits PTPN6 resulting in dephosphorylation of CD247 and ZAP70 (PubMed:18424730). Also inhibits T cell proliferation and cytokine production through inhibition of JNK cascade and plays a crucial role in regulating autoimmunity and anti-tumor immunity by inhibiting T cell through its interaction with HAVCR2 (PubMed:25363763). Upon natural killer (NK) cells activation, inhibit KLRK1-mediated cytolysis of CEACAM1-bearing tumor cells by trans-homophilic interactions with CEACAM1 on the target cell and lead to cis-interaction between CEACAM1 and KLRK1, allowing PTPN6 recruitment and then VAV1 dephosphorylation (PubMed:23696226). Upon neutrophils activation negatively regulates IL1B production by recruiting PTPN6 to a SYK-TLR4-CEACAM1 complex, that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, which in turn, reduces the activity of the inflammasome. Downregulates neutrophil production by acting as a coinhibitory receptor for CSF3R by downregulating the CSF3R-STAT3 pathway through recruitment of PTPN6 that dephosphorylates CSF3R (By similarity). Also regulates insulin action by promoting INS clearance and regulating lipogenesis in liver through regulating insulin signaling (By similarity). Upon INS stimulation, undergoes phosphorylation by INSR leading to INS clearance by increasing receptor-mediated insulin endocytosis. This inernalization promotes interaction with FASN leading to receptor-mediated insulin degradation and to reduction of FASN activity leading to negative regulation of fatty acid synthesis. INSR-mediated phosphorylation also provokes a down-regulation of cell proliferation through SHC1 interaction resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 and phosphatidylinositol 3-kinase pathways (By similarity). Functions as activator in angiogenesis by promoting blood vessel remodeling through endothelial cell differentiation and migration and in arteriogenesis by increasing the number of collateral arteries and collateral vessel calibers after ischemia. Also regulates vascular permeability through the VEGFR2 signaling pathway resulting in control of nitric oxide production (By similarity). Downregulates cell growth in response to EGF through its interaction with SHC1 that mediates interaction with EGFR resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 pathway (By similarity). Negatively regulates platelet aggregation by decreasing platelet adhesion on type I collagen through the GPVI-FcRgamma complex (By similarity). Inhibits cell migration and cell scattering through interaction with FLNA; interfers with the interaction of FLNA with RALA (PubMed:16291724). Mediates bile acid transport activity in a phosphorylation dependent manner (By similarity). Negatively regulates osteoclastogenesis (By similarity)."	""	"FALSE"
"8034-6_3"	""	"DRGX"	"Dorsal root ganglia homeobox protein"	"10"	"50572226"	"50604062"	"DRGX"	"ENSG00000165606"	"A6NNA5"	""	""	""	""	""	""	""	"Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain."	""	"FALSE"
"8038-41_3"	""	"NSDHL"	"Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating"	"X"	"151999511"	"152038273"	"NSDHL"	"ENSG00000147383"	"Q15738"	""	""	""	""	""	""	""	"Involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis."	""	"FALSE"
"8039-41_3"	""	"F177A"	"Protein FAM177A1"	"14"	"35514113"	"35582336"	"FAM177A1"	"ENSG00000151327"	"Q8N128"	""	""	""	""	""	""	""	"alternative splicing"	""	"FALSE"
"8040-9_3"	""	"LEMD1"	"LEM domain-containing protein 1"	"1"	"205350506"	"205426219"	"LEMD1"	"ENSG00000186007"	"Q68G75"	""	""	""	""	""	""	""	"Membrane"	""	"FALSE"
"8041-5_3"	""	"FNDC5"	"Fibronectin type III domain-containing protein 5"	"1"	"33327869"	"33338083"	"FNDC5"	"ENSG00000160097"	"Q8NAU1"	""	""	""	""	""	""	""	"Irisin: Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue."	""	"FALSE"
"8044-90_3"	""	"XG"	"Glycoprotein Xg"	"X"	"2670091"	"2733968"	"XG"	"ENSG00000124343"	"P55808"	""	""	""	""	""	""	""	"Cell membrane"	""	"FALSE"
"8053-16_3"	""	"DJB14"	"DnaJ homolog subfamily B member 14"	"4"	"100817405"	"100867883"	"DNAJB14"	"ENSG00000164031"	"Q8TBM8"	""	""	""	""	""	""	""	"Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (PubMed:24732912). Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities (PubMed:24732912). Can also act independently of HSPA8/Hsc70: together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers (PubMed:27916661). While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 (PubMed:27916661). When overexpressed, forms membranous structures together with DNAJB12 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear (PubMed:24732912)."	""	"FALSE"
"8065-245_3"	""	"PATE4"	"Prostate and testis expressed protein 4"	"11"	"125703211"	"125709964"	"PATE4"	"ENSG00000237353"	"P0C8F1"	""	""	""	""	""	""	""	"May modulate the function of nicotinic acetylcholine receptors. May enhance sperm motility."	""	"FALSE"
"8068-43_3"	""	"K1161"	"Uncharacterized family 31 glucosidase KIAA1161"	"9"	"34366668"	"34376851"	"KIAA1161"	"ENSG00000164976"	"Q6NSJ0"	""	""	""	""	""	""	""	"Putative glycosidase. Promotes myogenesis by activating AKT signaling through the maturation and secretion of IGF2."	""	"FALSE"
"8069-85_3"	""	"CD3E"	"T-cell surface glycoprotein CD3 epsilon chain"	"11"	"118175260"	"118186890"	"CD3E"	"ENSG00000198851"	"P07766"	""	""	""	""	""	""	""	"Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell developement. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (PubMed:10384095, PubMed:26507128)."	""	"FALSE"
"8076-4_3"	""	"SACA3"	"Sperm acrosome membrane-associated protein 3"	"17"	"31297394"	"31324895"	"SPACA3"	"ENSG00000141316"	"Q8IXA5"	""	""	""	""	""	""	""	"Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro."	""	"FALSE"
"8078-15_3"	""	"CF226"	"Uncharacterized protein C6orf226"	"6"	"42858003"	"42858554"	"C6orf226"	"ENSG00000221821"	"Q5I0X4"	""	""	""	""	""	""	""	"EBI-10244057"	""	"FALSE"
"8087-250_3"	""	"RNF13"	"E3 ubiquitin-protein ligase RNF13"	"3"	"149530495"	"149679926"	"RNF13"	"ENSG00000082996"	"O43567"	""	""	""	""	""	""	""	"E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation."	""	"FALSE"
"8092-29_3"	""	"IL-6 sRa"	"Interleukin-6 receptor subunit alpha"	"1"	"154377669"	"154441926"	"IL6R"	"ENSG00000160712"	"P08887"	""	""	""	""	""	""	""	"Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis."	""	"FALSE"
"8097-77_3"	""	"LIPN"	"Lipase member N"	"10"	"90521163"	"90537999"	"LIPN"	"ENSG00000204020"	"Q5VXI9"	""	""	""	""	""	""	""	"Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers."	""	"FALSE"
"8220-15_3"	""	"CJ035"	"Uncharacterized protein C10orf35"	"10"	"71390007"	"71393355"	"C10orf35"	"ENSG00000171224"	"Q96D05"	""	""	""	""	""	""	""	"EBI-2548784"	""	"FALSE"
"8225-86_3"	""	"EPHB2"	"Ephrin type-B receptor 2"	"1"	"23037332"	"23247993"	"EPHB2"	"ENSG00000133216"	"P29323"	""	""	""	""	""	""	""	"Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor."	""	"FALSE"
"8229-1_3"	""	"GXLT1"	"Glucoside xylosyltransferase 1"	"12"	"42475647"	"42538681"	"GXYLT1"	"ENSG00000151233"	"Q4G148"	""	""	""	""	""	""	""	"Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose."	""	"FALSE"
"8232-90_3"	""	"JAML1"	"Junctional adhesion molecule-like"	"11"	"118064455"	"118095809"	"AMICA1"	"ENSG00000160593"	"Q86YT9"	""	""	""	""	""	""	""	"Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR."	""	"FALSE"
"8233-2_3"	""	"ITIH5"	"Inter-alpha-trypsin inhibitor heavy chain H5"	"10"	"7601232"	"7708961"	"ITIH5"	"ENSG00000123243"	"Q86UX2"	""	""	""	""	""	""	""	"May act as a tumor suppressor."	""	"FALSE"
"8240-207_3"	""	"GPNMB"	"Transmembrane glycoprotein NMB"	"7"	"23275586"	"23314727"	"GPNMB"	"ENSG00000136235"	"Q14956"	""	""	""	""	""	""	""	"Could be a melanogenic enzyme."	""	"FALSE"
"8244-16_3"	""	"FUT8"	"Alpha-(1,6)-fucosyltransferase"	"14"	"65877310"	"66210839"	"FUT8"	"ENSG00000033170"	"Q9BYC5"	""	""	""	""	""	""	""	"Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans."	""	"FALSE"
"8245-27_3"	""	"sICAM-5"	"Intercellular adhesion molecule 5"	"19"	"10400657"	"10407454"	"ICAM5"	"ENSG00000105376"	"Q9UMF0"	""	""	""	""	""	""	""	"ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2)."	""	"FALSE"
"8248-222_3"	""	"SIG14"	"Sialic acid-binding Ig-like lectin 14"	"19"	"52145806"	"52150054"	"SIGLEC14"	"ENSG00000254415"	"Q08ET2"	""	""	""	""	""	""	""	"Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors."	""	"FALSE"
"8255-34_3"	""	"MRVI1"	"Protein MRVI1"	"11"	"10594638"	"10715535"	"MRVI1"	"ENSG00000072952"	"Q9Y6F6"	""	""	""	""	""	""	""	"Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation."	""	"FALSE"
"8256-57_3"	""	"RANK"	"Tumor necrosis factor receptor superfamily member 11A"	"18"	"59992520"	"60058525"	"TNFRSF11A"	"ENSG00000141655"	"Q9Y6Q6"	""	""	""	""	""	""	""	"Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells."	""	"FALSE"
"8259-25_3"	""	"B3GN1"	"Beta-1,4-glucuronyltransferase 1"	"11"	"66112843"	"66115163"	"B4GAT1"	"ENSG00000174684"	"O43505"	""	""	""	""	""	""	""	"Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE1, during synthesis of phosphorylated O-mannosyl glycan (PubMed:25279699, PubMed:25279697). Phosphorylated O-mannosyl glycan is a carbohydrate is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:25279699, PubMed:25279697). Required for axon guidance; via its function in O-mannosylation of alpha-dystroglycan (DAG1) (By similarity)."	""	"FALSE"
"8260-13_3"	""	"PDZ1I"	"PDZK1-interacting protein 1"	"1"	"47649265"	"47656716"	"PDZK1IP1"	"ENSG00000162366"	"Q13113"	""	""	""	""	""	""	""	"May play an important role in tumor biology."	""	"FALSE"
"8261-51_3"	""	"STOM"	"Erythrocyte band 7 integral membrane protein"	"9"	"124101266"	"124132582"	"STOM"	"ENSG00000148175"	"P27105"	""	""	""	""	""	""	""	"Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity."	""	"FALSE"
"8265-225_3"	""	"LAP2B"	"Lamina-associated polypeptide 2, isoforms beta/gamma"	"12"	"98909290"	"98944157"	"TMPO"	"ENSG00000120802"	"P42167"	""	""	""	""	""	""	""	"May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95."	""	"FALSE"
"8268-98_3"	""	"HS3SA"	"Heparan sulfate glucosamine 3-O-sulfotransferase 3A1"	"17"	"13399006"	"13505244"	"HS3ST3A1"	"ENSG00000153976"	"Q9Y663"	""	""	""	""	""	""	""	"Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate."	""	"FALSE"
"8269-327_3"	""	"ARSK"	"Arylsulfatase K"	"5"	"94890778"	"94940768"	"ARSK"	"ENSG00000164291"	"Q6UWY0"	""	""	""	""	""	""	""	"Ca(2+)"	""	"FALSE"
"8274-64_3"	""	"Syntaxin-7"	"Syntaxin-7"	"6"	"132767006"	"132834337"	"STX7"	"ENSG00000079950"	"O15400"	""	""	""	""	""	""	""	"May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes."	""	"FALSE"
"8275-31_3"	""	"PEAR1"	"Platelet endothelial aggregation receptor 1"	"1"	"156863490"	"156886226"	"PEAR1"	"ENSG00000187800"	"Q5VY43"	""	""	""	""	""	""	""	"When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells."	""	"FALSE"
"8280-238_3"	""	"Vitronectin"	"Vitronectin"	"17"	"26694297"	"26700110"	"VTN"	"ENSG00000109072"	"P04004"	""	""	""	""	""	""	""	"Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway."	""	"FALSE"
"8282-15_3"	""	"CLC5A"	"C-type lectin domain family 5 member A"	"7"	"141627157"	"141646807"	"CLEC5A"	"ENSG00000258227"	"Q9NY25"	""	""	""	""	""	""	""	"Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation (By similarity). Critical macrophage receptor for dengue virus serotypes 1-4."	""	"FALSE"
"8289-8_3"	""	"GPNMB"	"Transmembrane glycoprotein NMB"	"7"	"23275586"	"23314727"	"GPNMB"	"ENSG00000136235"	"Q14956"	""	""	""	""	""	""	""	"Could be a melanogenic enzyme."	""	"FALSE"
"8296-117_3"	""	"KDEL2"	"KDEL motif-containing protein 2"	"11"	"108342832"	"108369159"	"KDELC2"	"ENSG00000178202"	"Q7Z4H8"	""	""	""	""	""	""	""	"Endoplasmic reticulum lumen"	""	"FALSE"
"8298-8_3"	""	"CG045"	"Serine-rich single-pass membrane protein 1"	"7"	"129847700"	"129856683"	"SSMEM1"	"ENSG00000165120"	"Q8WWF3"	""	""	""	""	""	""	""	"Membrane"	""	"FALSE"
"8299-66_3"	""	"LIRA4"	"Leukocyte immunoglobulin-like receptor subfamily A member 4"	"19"	"54844456"	"54850421"	"LILRA4"	"ENSG00000239961"	"P59901"	""	""	""	""	""	""	""	"Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades (PubMed:16735691, PubMed:19564354, PubMed:24586760). Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells (PubMed:26172439). Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+) (PubMed:16735691, PubMed:19564354). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells (PubMed:24586760)."	""	"FALSE"
"8305-18_3"	""	"SULF2"	"Extracellular sulfatase Sulf-2"	"20"	"46285092"	"46415360"	"SULF2"	"ENSG00000196562"	"Q8IWU5"	""	""	""	""	""	""	""	"Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin."	""	"FALSE"
"8307-47_3"	""	"CK068"	"UPF0696 protein C11orf68"	"11"	"65684279"	"65686588"	"C11orf68"	"ENSG00000175573"	"Q9H3H3"	""	""	""	""	""	""	""	"EBI-721765"	""	"FALSE"
"8316-36_3"	""	"RANK"	"Tumor necrosis factor receptor superfamily member 11A"	"18"	"59992520"	"60058525"	"TNFRSF11A"	"ENSG00000141655"	"Q9Y6Q6"	""	""	""	""	""	""	""	"Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells."	""	"FALSE"
"8326-63_3"	""	"SIGIRR"	"Single Ig IL-1-related receptor"	"11"	"405716"	"417455"	"SIGIRR"	"ENSG00000185187"	"Q6IA17"	""	""	""	""	""	""	""	"Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP."	""	"FALSE"
"8327-26_3"	""	"DPEP2"	"Dipeptidase 2"	"16"	"68021297"	"68034489"	"DPEP2"	"ENSG00000167261"	"Q9H4A9"	""	""	""	""	""	""	""	"Probable metalloprotease which hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4)."	""	"FALSE"
"8336-267_3"	""	"GRM1C"	"GRAM domain-containing protein 1C"	"3"	"113547029"	"113666021"	"GRAMD1C"	"ENSG00000178075"	"Q8IYS0"	""	""	""	""	""	""	""	"EBI-7054335"	""	"FALSE"
"8339-72_3"	""	"Gastrin-releasing peptide"	"Gastrin-releasing peptide"	"18"	"56887400"	"56898006"	"GRP"	"ENSG00000134443"	"P07492"	""	""	""	""	""	""	""	"Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity)."	""	"FALSE"
"8345-27_3"	""	"GPX7"	"Glutathione peroxidase 7"	"1"	"53068044"	"53074723"	"GPX7"	"ENSG00000116157"	"Q96SL4"	""	""	""	""	""	""	""	"It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks."	""	"FALSE"
"8346-9_3"	""	"DPP2"	"Dipeptidyl peptidase 2"	"9"	"140004994"	"140009629"	"DPP7"	"ENSG00000176978"	"Q9UHL4"	""	""	""	""	""	""	""	"Plays an important role in the degradation of some oligopeptides."	""	"FALSE"
"8348-4_3"	""	"EPHB2"	"Ephrin type-B receptor 2"	"1"	"23037332"	"23247993"	"EPHB2"	"ENSG00000133216"	"P29323"	""	""	""	""	""	""	""	"Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor."	""	"FALSE"
"8352-26_3"	""	"SIG12"	"Sialic acid-binding Ig-like lectin 12"	"19"	"51994611"	"52005043"	"SIGLEC12"	"ENSG00000254521"	"Q96PQ1"	""	""	""	""	""	""	""	"Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface."	""	"FALSE"
"8355-80_3"	""	"ISM1"	"Isthmin-1"	"20"	"13202418"	"13281298"	"ISM1"	"ENSG00000101230"	"B1AKI9"	""	""	""	""	""	""	""	"Acts as an angiogenesis inhibitor."	""	"FALSE"
"8360-169_3"	""	"NKp46"	"Natural cytotoxicity triggering receptor 1"	"19"	"55417508"	"55427508"	"NCR1"	"ENSG00000189430"	"O76036"	""	""	""	""	""	""	""	"Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis."	""	"FALSE"
"8363-18_3"	""	"K132L"	"UPF0577 protein KIAA1324-like"	"7"	"86506222"	"86689015"	"KIAA1324L"	"ENSG00000164659"	"A8MWY0"	""	""	""	""	""	""	""	"Membrane"	""	"FALSE"
"8368-102_3"	""	"TNF sR-II"	"Tumor necrosis factor receptor superfamily member 1B"	"1"	"12227060"	"12269285"	"TNFRSF1B"	"ENSG00000028137"	"P20333"	""	""	""	""	""	""	""	"Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity."	""	"FALSE"
"8370-102_3"	""	"DB119"	"Beta-defensin 119"	"20"	"29964967"	"29978406"	"DEFB119"	"ENSG00000180483"	"Q8N690"	""	""	""	""	""	""	""	"Has antibacterial activity."	""	"FALSE"
"8372-29_3"	""	"CDHR1"	"Cadherin-related family member 1"	"10"	"85954391"	"85979377"	"CDHR1"	"ENSG00000148600"	"Q96JP9"	""	""	""	""	""	""	""	"Potential calcium-dependent cell-adhesion protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells (By similarity)."	""	"FALSE"
"8374-5_3"	""	"NGF R"	"Tumor necrosis factor receptor superfamily member 16"	"17"	"47572655"	"47592379"	"NGFR"	"ENSG00000064300"	"P08138"	""	""	""	""	""	""	""	"Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver."	""	"FALSE"
"8376-25_4"	""	"LSHB"	"Lutropin subunit beta"	"19"	"49519237"	"49520347"	"LHB"	"ENSG00000104826"	"P01229"	""	""	""	""	""	""	""	"Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids."	""	"FALSE"
"8378-3_4"	""	"LDOC1"	"Protein LDOC1"	"X"	"140269930"	"140271310"	"LDOC1"	"ENSG00000182195"	"O95751"	""	""	""	""	""	""	""	"May have an important role in the development and/or progression of some cancers."	""	"FALSE"
"8382-47_3"	""	"MAPK5"	"MAP kinase-activated protein kinase 5"	"12"	"112279782"	"112340042"	"MAPKAPK5"	"ENSG00000089022"	"Q8IW41"	""	""	""	""	""	""	""	"Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement."	""	"FALSE"
"8389-8_3"	""	"CN16B"	"Leucine-rich repeat-containing protein 74A"	"14"	"77292715"	"77336645"	"LRRC74A"	"ENSG00000100565"	"Q0VAA2"	""	""	""	""	""	""	""	"alternative splicing"	""	"FALSE"
"8394-56_3"	""	"RNase 2"	"Non-secretory ribonuclease"	"14"	"21423611"	"21424595"	"RNASE2"	"ENSG00000169385"	"P10153"	""	""	""	""	""	""	""	"This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities."	""	"FALSE"
"8397-147_3"	""	"QSOX2"	"Sulfhydryl oxidase 2"	"9"	"139098179"	"139137687"	"QSOX2"	"ENSG00000165661"	"Q6ZRP7"	""	""	""	""	""	""	""	"Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis."	""	"FALSE"
"8398-277_3"	""	"RAR-responsive protein TIG1"	"Retinoic acid receptor responder protein 1"	"3"	"158414681"	"158450485"	"RARRES1"	"ENSG00000118849"	"P49788"	""	""	""	""	""	""	""	"Inhibitor of the cytoplasmic carboxypeptidase AGBL2, may regulate the alpha-tubulin tyrosination cycle."	""	"FALSE"
"8400-74_3"	""	"Gastrin-releasing peptide"	"Gastrin-releasing peptide"	"18"	"56887400"	"56898006"	"GRP"	"ENSG00000134443"	"P07492"	""	""	""	""	""	""	""	"Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity)."	""	"FALSE"
"8429-16_3"	""	"AXIN2"	"Axin-2"	"17"	"63524681"	"63557765"	"AXIN2"	"ENSG00000168646"	"Q9Y2T1"	""	""	""	""	""	""	""	"Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B (By similarity)."	""	"FALSE"
"8458-111_3"	""	"a-Synuclein"	"Alpha-synuclein"	"4"	"90645250"	"90759466"	"SNCA"	"ENSG00000145335"	"P37840"	""	""	""	""	""	""	""	"May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation."	""	"FALSE"
"8459-10_3"	""	"BMP-6"	"Bone morphogenetic protein 6"	"6"	"7727030"	"7881655"	"BMP6"	"ENSG00000153162"	"P22004"	""	""	""	""	""	""	""	"Induces cartilage and bone formation."	""	"FALSE"
"8463-2_3"	""	"SOD3"	"Extracellular superoxide dismutase [Cu-Zn]"	"4"	"24791534"	"24802464"	"SOD3"	"ENSG00000109610"	"P08294"	""	""	""	""	""	""	""	"Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen."	""	"FALSE"
"8465-52_3"	""	"Cathepsin H"	"Cathepsin H"	"15"	"79213400"	"79241916"	"CTSH"	"ENSG00000103811"	"P09668"	""	""	""	""	""	""	""	"Important for the overall degradation of proteins in lysosomes."	""	"FALSE"
"8476-11_3"	""	"CgA"	"Chromogranin-A"	"14"	"93389425"	"93401638"	"CHGA"	"ENSG00000100604"	"P10645"	""	""	""	""	""	""	""	"Pancreastatin: Strongly inhibits glucose induced insulin release from the pancreas."	""	"FALSE"
"8479-4_3"	""	"MMP-10"	"Stromelysin-2"	"11"	"102641234"	"102651359"	"MMP10"	"ENSG00000166670"	"P09238"	""	""	""	""	""	""	""	"Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase."	""	"FALSE"
"8545-14_3"	""	"CQ078"	"Uncharacterized protein C17orf78"	"17"	"35732928"	"35749662"	"C17orf78"	"ENSG00000278505"	"Q8N4C9"	""	""	""	""	""	""	""	"Membrane"	""	"FALSE"
"8578-45_3"	""	"AMELX"	"Amelogenin, X isoform"	"X"	"11311533"	"11318881"	"AMELX"	"ENSG00000125363"	"Q99217"	""	""	""	""	""	""	""	"Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel."	""	"FALSE"
"8601-167_3"	""	"sLRP1"	"Low-density lipoprotein receptor-related protein 1, soluble"	"12"	"57522276"	"57607134"	"LRP1"	"ENSG00000123384"	"Q07954"	""	""	""	""	""	""	""	"Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed:11907044, PubMed:12888553, PubMed:12713657). Acts as an alpha-2-macroglobulin receptor (PubMed:26142438)."	""	"FALSE"
"8606-39_3"	""	"GPNMB"	"Transmembrane glycoprotein NMB"	"7"	"23275586"	"23314727"	"GPNMB"	"ENSG00000136235"	"Q14956"	""	""	""	""	""	""	""	"Could be a melanogenic enzyme."	""	"FALSE"
"8620-56_3"	""	"kallikrein 14"	"Kallikrein-14"	"19"	"51580752"	"51587502"	"KLK14"	"ENSG00000129437"	"Q9P0G3"	""	""	""	""	""	""	""	"Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis."	""	"FALSE"
"8631-13_3"	""	"ERMAP"	"Erythroid membrane-associated protein"	"1"	"43282795"	"43310660"	"ERMAP"	"ENSG00000164010"	"Q96PL5"	""	""	""	""	""	""	""	"Possible role as a cell-adhesion or receptor molecule of erythroid cells."	""	"FALSE"
"8683-119_3"	""	"PILRA"	"Paired immunoglobulin-like type 2 receptor alpha"	"7"	"99965153"	"99997722"	"PILRA"	"ENSG00000085514"	"Q9UKJ1"	""	""	""	""	""	""	""	"Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP."	""	"FALSE"
"8697-38_3"	""	"Glypican 1"	"Glypican-1"	"2"	"241375088"	"241407495"	"GPC1"	"ENSG00000063660"	"P35052"	""	""	""	""	""	""	""	"Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling."	""	"FALSE"
"8755-202_3"	""	"HLA-DPB1"	"HLA class II histocompatibility antigen, DP beta 1 chain"	"6"	"33043703"	"33054978"	"HLA-DPB1"	"ENSG00000223865"	"P04440"	""	""	""	""	""	""	""	"Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading."	""	"FALSE"
"8758-2_3"	""	"PCDA7"	"Protocadherin alpha-7"	"5"	"140213833"	"140391929"	"PCDHA7"	"ENSG00000204963"	"Q9UN72"	""	""	""	""	""	""	""	"Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain."	""	"FALSE"
"8760-10_3"	""	"DCNL5"	"DCN1-like protein 5"	"11"	"102932805"	"102962944"	"DCUN1D5"	"ENSG00000137692"	"Q9BTE7"	""	""	""	""	""	""	""	"EBI-3924013"	""	"FALSE"
"8766-29_3"	""	"LIRA5"	"Leukocyte immunoglobulin-like receptor subfamily A member 5"	"19"	"54818353"	"54824409"	"LILRA5"	"ENSG00000187116"	"A6NI73"	""	""	""	""	""	""	""	"May play a role in triggering innate immune responses. Does not seem to play a role for any class I MHC antigen recognition."	""	"FALSE"
"8767-44_3"	""	"Endothelin-converting enzyme 1"	"Endothelin-converting enzyme 1"	"1"	"21543740"	"21671997"	"ECE1"	"ENSG00000117298"	"P42892"	""	""	""	""	""	""	""	"Converts big endothelin-1 to endothelin-1."	""	"FALSE"
"8768-4_3"	""	"Bcl-10"	"B-cell lymphoma/leukemia 10"	"1"	"85731931"	"85742773"	"BCL10"	"ENSG00000142867"	"O95999"	""	""	""	""	""	""	""	"Involved in adaptive immune response (PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 (PubMed:18264101)."	""	"FALSE"
"8770-136_3"	""	"SLAF5"	"SLAM family member 5"	"1"	"160510885"	"160549306"	"CD84"	"ENSG00000066294"	"Q9UIB8"	""	""	""	""	""	""	""	"Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B (By similarity). Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seem be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A-dependent pathway. May serve as a marker for hematopoietic progenitor cells (PubMed:11564780, PubMed:12115647. PubMed:12928397, PubMed:12962726, PubMed:16037392) Required for a prolonged T-cell:B-cell contact, optimal T follicular helper function, and germinal center formation. In germinal centers involved in maintaining B-cell tolerance and in preventing autoimmunity (By similarity). In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1 (PubMed:22068234). In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2 (By similarity)."	""	"FALSE"
"8773-172_3"	""	"EMIL3"	"EMILIN-3"	"20"	"39988606"	"39995467"	"EMILIN3"	"ENSG00000183798"	"Q9NT22"	""	""	""	""	""	""	""	"EBI-3197883"	""	"FALSE"
"8776-10_3"	""	"ERLN1"	"Erlin-1"	"10"	"101909851"	"101948091"	"SPFH1"	"ENSG00000107566"	"O75477"	""	""	""	""	""	""	""	"Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (PubMed:24217618)."	""	"FALSE"
"8780-2_3"	""	"PCD10"	"Protocadherin-10"	"4"	"134070470"	"134129761"	"PCDH10"	"ENSG00000138650"	"Q9P2E7"	""	""	""	""	""	""	""	"Potential calcium-dependent cell-adhesion protein."	""	"FALSE"
"8791-151_3"	""	"Carbonic Anhydrase VA"	"Carbonic anhydrase 5A, mitochondrial"	"16"	"87915152"	"87970135"	"CA5A"	"ENSG00000174990"	"P35218"	""	""	""	""	""	""	""	"Reversible hydration of carbon dioxide. Low activity."	""	"FALSE"
"8795-48_3"	""	"TR"	"Transferrin receptor protein 1"	"3"	"195754054"	"195809060"	"TFRC"	"ENSG00000072274"	"P02786"	""	""	""	""	""	""	""	"Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240)."	""	"FALSE"
"8814-33_3"	""	"SAPL1"	"Proactivator polypeptide-like 1"	"4"	"7433985"	"7436672"	"PSAPL1"	"ENSG00000178597"	"Q6NUJ1"	""	""	""	""	""	""	""	"May activate the lysosomal degradation of sphingolipids."	""	"FALSE"
"8829-4_3"	""	"RAP"	"alpha-2-macroglobulin receptor-associated protein"	"4"	"3508103"	"3534286"	"LRPAP1"	"ENSG00000163956"	"P30533"	""	""	""	""	""	""	""	"Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway."	""	"FALSE"
"8834-58_3"	""	"Calnexin"	"Calnexin"	"5"	"179105629"	"179157926"	"CANX"	"ENSG00000127022"	"P27824"	""	""	""	""	""	""	""	"Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse."	""	"FALSE"
"8842-16_3"	""	"GRM1C"	"GRAM domain-containing protein 1C"	"3"	"113547029"	"113666021"	"GRAMD1C"	"ENSG00000178075"	"Q8IYS0"	""	""	""	""	""	""	""	"EBI-7054335"	""	"FALSE"
"8851-42_3"	""	"F171B"	"Protein FAM171B"	"2"	"187558698"	"187630692"	"FAM171B"	"ENSG00000144369"	"Q6P995"	""	""	""	""	""	""	""	"Membrane"	""	"FALSE"
"8852-10_3"	""	"SUN3"	"SUN domain-containing protein 3"	"7"	"48026745"	"48068716"	"SUN3"	"ENSG00000164744"	"Q8TAQ9"	""	""	""	""	""	""	""	"As a probable component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nuclear remodeling during sperm head formation in spermatogenenis. A probable SUN3:SYNE1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette."	""	"FALSE"
"8854-59_3"	""	"RIR2B"	"Ribonucleoside-diphosphate reductase subunit M2 B"	"8"	"103216730"	"103251346"	"RRM2B"	"ENSG00000048392"	"Q7LG56"	""	""	""	""	""	""	""	"Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage."	""	"FALSE"
"8858-21_3"	""	"BATF3"	"Basic leucine zipper transcriptional factor ATF-like 3"	"1"	"212859760"	"212873327"	"BATF3"	"ENSG00000123685"	"Q9NR55"	""	""	""	""	""	""	""	"AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity). Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes."	""	"FALSE"
"8866-53_3"	""	"QPCTL"	"Glutaminyl-peptide cyclotransferase-like protein"	"19"	"46195741"	"46207247"	"QPCTL"	"ENSG00000011478"	"Q9NXS2"	""	""	""	""	""	""	""	"Responsible for the biosynthesis of pyroglutamyl peptides."	""	"FALSE"
"8877-22_3"	""	"F176C"	"Protein eva-1 homolog C"	"21"	"33784314"	"33887707"	"EVA1C"	"ENSG00000166979"	"P58658"	""	""	""	""	""	""	""	"Binds heparin."	""	"FALSE"
"8885-6_3"	""	"CA2D3"	"Voltage-dependent calcium channel subunit alpha-2/delta-3"	"3"	"54156574"	"55108584"	"CACNA2D3"	"ENSG00000157445"	"Q8IZS8"	""	""	""	""	""	""	""	"The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity)."	""	"FALSE"
"8887-21_3"	""	"NUDC"	"Nuclear migration protein nudC"	"1"	"27226729"	"27273353"	"NUDC"	"ENSG00000090273"	"Q9Y266"	""	""	""	""	""	""	""	"Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation."	""	"FALSE"
"8888-33_3"	""	"CX068"	"Small integral membrane protein 9"	"X"	"154051623"	"154062937"	"SMIM9"	"ENSG00000203870"	"A6NGZ8"	""	""	""	""	""	""	""	"Cell membrane"	""	"FALSE"
"8890-9_3"	""	"T132B"	"Transmembrane protein 132B"	"12"	"125671382"	"126146923"	"TMEM132B"	"ENSG00000139364"	"Q14DG7"	""	""	""	""	""	""	""	"Membrane"	""	"FALSE"
"8891-7_3"	""	"CPVL"	"Probable serine carboxypeptidase CPVL"	"7"	"29034847"	"29235067"	"CPVL"	"ENSG00000106066"	"Q9H3G5"	""	""	""	""	""	""	""	"May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation."	""	"FALSE"
"8894-80_3"	""	"hnRNP A/B"	"Heterogeneous nuclear ribonucleoprotein A/B"	"5"	"177631508"	"177638181"	"HNRNPAB"	"ENSG00000197451"	"Q99729"	""	""	""	""	""	""	""	"Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site."	""	"FALSE"
"8900-28_3"	""	"NEO1"	"Neogenin"	"15"	"73344051"	"73597547"	"NEO1"	"ENSG00000067141"	"Q92859"	""	""	""	""	""	""	""	"Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response."	""	"FALSE"
"8903-1_3"	""	"COX6C"	"Cytochrome c oxidase subunit 6C"	"8"	"100885428"	"100906290"	"COX6C"	"ENSG00000164919"	"P09669"	""	""	""	""	""	""	""	"This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport."	""	"FALSE"
"8906-60_3"	""	"LRTM2"	"Leucine-rich repeat and transmembrane domain-containing protein 2"	"12"	"1929433"	"1945918"	"LRTM2"	"ENSG00000166159"	"Q8N967"	""	""	""	""	""	""	""	"Membrane"	""	"FALSE"
"8907-11_3"	""	"UD2A1"	"UDP-glucuronosyltransferase 2A1"	"4|4|4"	"70454135|70455027|70454912"	"70518967|70505360|70518967"	"UGT2A1|UGT2A2|UGT2A1"	"ENSG00000173610|ENSG00000271271|ENSG00000270386"	"Q9Y4X1|Q9Y4X1|Q9Y4X1"	""	""	""	""	""	""	""	"UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Active on odorants and seems to be involved in olfaction; it could help clear lipophilic odorant molecules from the sensory epithelium."	""	"FALSE"
"8908-14_3"	""	"KCE1L"	"Potassium voltage-gated channel subfamily E regulatory beta subunit 5"	"X"	"108866929"	"108868401"	"KCNE5"	"ENSG00000176076"	"Q9UJ90"	""	""	""	""	""	""	""	"Potassium channel ancillary subunit that is essential for generation of some native K(+) currents by virtue of formation of heteromeric ion channel complex with voltage-gated potassium (Kv) channel pore-forming alpha subunits. Functions as an inhibitory beta-subunit of the repolarizing cardiac potassium ion channel KCNQ1."	""	"FALSE"
"8909-77_3"	""	"GNPI1"	"Glucosamine-6-phosphate isomerase 1"	"5"	"141371314"	"141392606"	"GNPDA1"	"ENSG00000113552"	"P46926"	""	""	""	""	""	""	""	"Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity)."	""	"FALSE"
"8913-22_3"	""	"SIG11"	"Sialic acid-binding Ig-like lectin 11"	"19"	"50452242"	"50464429"	"SIGLEC11"	"ENSG00000161640"	"Q96RL6"	""	""	""	""	""	""	""	"Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules."	""	"FALSE"
"8918-64_3"	""	"FAK2"	"Protein-tyrosine kinase 2-beta"	"8"	"27168999"	"27316908"	"PTK2B"	"ENSG00000120899"	"Q14289"	""	""	""	""	""	""	""	"Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2."	""	"FALSE"
"8923-94_3"	""	"GLTL1"	"Polypeptide N-acetylgalactosaminyltransferase 16"	"14"	"69725994"	"69823750"	"GALNT16"	"ENSG00000100626"	"Q8N428"	""	""	""	""	""	""	""	"Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor."	""	"FALSE"
"8925-25_3"	""	"RIR2B"	"Ribonucleoside-diphosphate reductase subunit M2 B"	"8"	"103216730"	"103251346"	"RRM2B"	"ENSG00000048392"	"Q7LG56"	""	""	""	""	""	""	""	"Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage."	""	"FALSE"
"8949-3_3"	""	"NGF R"	"Tumor necrosis factor receptor superfamily member 16"	"17"	"47572655"	"47592379"	"NGFR"	"ENSG00000064300"	"P08138"	""	""	""	""	""	""	""	"Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver."	""	"FALSE"
"8955-60_3"	""	"GL8D1"	"Glycosyltransferase 8 domain-containing protein 1"	"3"	"52728501"	"52740099"	"GLT8D1"	"ENSG00000016864"	"Q68CQ7"	""	""	""	""	""	""	""	"Membrane"	""	"FALSE"
"8956-96_3"	""	"SREC-II"	"Scavenger receptor class F member 2"	"22"	"20778875"	"20792146"	"SCARF2"	"ENSG00000244486"	"Q96GP6"	""	""	""	""	""	""	""	"Probable adhesion protein, which mediates homophilic and heterophilic interactions. In contrast to SCARF1, it poorly mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL) (By similarity)."	""	"FALSE"
"8957-72_3"	""	"XTP3B"	"Endoplasmic reticulum lectin 1"	"2"	"54014181"	"54045956"	"ERLEC1"	"ENSG00000068912"	"Q96DZ1"	""	""	""	""	""	""	""	"Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins."	""	"FALSE"
"8960-3_3"	""	"LRAP"	"Endoplasmic reticulum aminopeptidase 2"	"5"	"96211643"	"96255420"	"ERAP2"	"ENSG00000164308"	"Q6P179"	""	""	""	""	""	""	""	"Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys."	""	"FALSE"
"8963-8_3"	""	"Vti1-rp1"	"Vesicle transport through interaction with t-SNAREs homolog 1B"	"14"	"68113792"	"68141548"	"VTI1B"	"ENSG00000100568"	"Q9UEU0"	""	""	""	""	""	""	""	"V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence."	""	"FALSE"
"8971-9_3"	""	"NRX1A"	"Neurexin-1"	"2"	"50145643"	"51259699"	"NRXN1"	"ENSG00000179915"	"Q9ULB1"	""	""	""	""	""	""	""	"Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their calcium-dependent interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom (By similarity)."	""	"FALSE"
"8973-23_3"	""	"FCRL4"	"Fc receptor-like protein 4"	"1"	"157543539"	"157567870"	"FCRL4"	"ENSG00000163518"	"Q96PJ5"	""	""	""	""	""	""	""	"May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response."	""	"FALSE"
"8974-172_3"	""	"COFA1"	"Collagen alpha-1(XV) chain"	"9"	"101705461"	"101833074"	"COL15A1"	"ENSG00000204291"	"P39059"	""	""	""	""	""	""	""	"Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle."	""	"FALSE"
"8980-19_3"	""	"MO2R2"	"Cell surface glycoprotein CD200 receptor 2"	"3"	"112534556"	"112565703"	"CD200R1L"	"ENSG00000206531"	"Q6Q8B3"	""	""	""	""	""	""	""	"May be a receptor for the CD200/OX2 cell surface glycoprotein."	""	"FALSE"
"8983-7_3"	""	"GOLM1"	"Golgi membrane protein 1"	"9"	"88641061"	"88715088"	"GOLM1"	"ENSG00000135052"	"Q8NBJ4"	""	""	""	""	""	""	""	"Unknown. Cellular response protein to viral infection."	""	"FALSE"
"8985-13_3"	""	"SRAC1"	"Protein SERAC1"	"6"	"158530547"	"158589302"	"SERAC1"	"ENSG00000122335"	"Q96JX3"	""	""	""	""	""	""	""	"Plays an important role in the phosphatidylglycerol remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. May catalyze the remodeling of phosphatidylglycerol and be involved in the transacylation-acylation reaction to produce phosphatidylglycerol-36:1. May be involved in bis(monoacylglycerol)phosphate biosynthetic pathway."	""	"FALSE"
"8992-1_3"	""	"TMEM2"	"Transmembrane protein 2"	"9"	"74298282"	"74431606"	"TMEM2"	"ENSG00000135048"	"Q9UHN6"	""	""	""	""	""	""	""	"Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate-size hyaluronan of approximately 5 kDa fragments (PubMed:28246172). Acts as a regulator of angiogenesis and heart morphogenesis by mediating degradation of extracellular hyaluronan, thereby regulating VEGF signaling (By similarity). Is very specific to hyaluronan; not able to cleave chondroitin sulfate or dermatan sulfate (PubMed:28246172)."	""	"FALSE"
"9005-16_3"	""	"PLXA1"	"Plexin-A1"	"3"	"126707437"	"126756235"	"PLXNA1"	"ENSG00000114554"	"Q9UIW2"	""	""	""	""	""	""	""	"Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity)."	""	"FALSE"
"9008-6_3"	""	"TMG1"	"Transmembrane gamma-carboxyglutamic acid protein 1"	"X"	"37208528"	"37316548"	"PRRG1"	"ENSG00000130962"	"O14668"	""	""	""	""	""	""	""	"Membrane"	""	"FALSE"
"9010-3_3"	""	"DMPK"	"Myotonin-protein kinase"	"19"	"46272975"	"46285810"	"DMPK"	"ENSG00000104936"	"Q09013"	""	""	""	""	""	""	""	"Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity."	""	"FALSE"
"9016-12_3"	""	"NR1H2"	"Oxysterols receptor LXR-beta"	"19"	"50832910"	"50886239"	"NR1H2"	"ENSG00000131408"	"P55055"	""	""	""	""	""	""	""	"Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957)."	""	"FALSE"
"9017-58_3"	""	"LPH"	"Lactase-phlorizin hydrolase"	"2"	"136545410"	"136594750"	"LCT"	"ENSG00000115850"	"P09848"	""	""	""	""	""	""	""	"LPH splits lactose in the small intestine."	""	"FALSE"
"9021-1_3"	""	"TIM-1"	"Hepatitis A virus cellular receptor 1"	"5"	"156456424"	"156486130"	"HAVCR1"	"ENSG00000113249"	"Q96D42"	""	""	""	""	""	""	""	"May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). May play a role in kidney injury and repair."	""	"FALSE"
"9023-9_3"	""	"CD34"	"Hematopoietic progenitor cell antigen CD34"	"1"	"208054317"	"208084747"	"CD34"	"ENSG00000174059"	"P28906"	""	""	""	""	""	""	""	"Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins."	""	"FALSE"
"9028-5_3"	""	"PAPD1"	"Poly(A) RNA polymerase, mitochondrial"	"10"	"30598730"	"30663377"	"MTPAP"	"ENSG00000107951"	"Q9NVV4"	""	""	""	""	""	""	""	"Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA."	""	"FALSE"
"9039-47_3"	""	"TOIP1"	"Torsin-1A-interacting protein 1"	"1"	"179851177"	"179894135"	"TOR1AIP1"	"ENSG00000143337"	"Q5JTV8"	""	""	""	""	""	""	""	"Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina."	""	"FALSE"
"9045-3_3"	""	"S27A2"	"Very long-chain acyl-CoA synthetase"	"15"	"50474393"	"50528592"	"SLC27A2"	"ENSG00000140284"	"O14975"	""	""	""	""	""	""	""	"Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precursors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes (By similarity)."	""	"FALSE"
"9046-46_3"	""	"LPPRC"	"Leucine-rich PPR motif-containing protein, mitochondrial"	"2"	"44113647"	"44223144"	"LRPPRC"	"ENSG00000138095"	"P42704"	""	""	""	""	""	""	""	"May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity)."	""	"FALSE"
"9061-3_3"	""	"ARHGA"	"Rho guanine nucleotide exchange factor 10"	"8"	"1772142"	"1906807"	"ARHGEF10"	"ENSG00000104728"	"O15013"	""	""	""	""	""	""	""	"May play a role in developmental myelination of peripheral nerves."	""	"FALSE"
"9065-28_3"	""	"TXLNA"	"Alpha-taxilin"	"1"	"32645287"	"32663886"	"TXLNA"	"ENSG00000084652"	"P40222"	""	""	""	""	""	""	""	"May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells."	""	"FALSE"
"9068-17_3"	""	"JKIP3"	"Janus kinase and microtubule-interacting protein 3"	"10"	"133918175"	"133998313"	"JAKMIP3"	"ENSG00000188385"	"Q5VZ66"	""	""	""	""	""	""	""	"Golgi apparatus"	""	"FALSE"
"9076-25_3"	""	"PENK"	"Proenkephalin-A"	"8"	"57349233"	"57359293"	"PENK"	"ENSG00000181195"	"P01210"	""	""	""	""	""	""	""	"Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum."	""	"FALSE"
"9077-10_3"	""	"MA1A2"	"Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB"	"1"	"117910071"	"118071494"	"MAN1A2"	"ENSG00000198162"	"O60476"	""	""	""	""	""	""	""	"Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2)."	""	"FALSE"
"9082-25_3"	""	"SE1L2"	"Protein sel-1 homolog 2"	"20"	"13829893"	"13977089"	"SEL1L2"	"ENSG00000101251"	"Q5TEA6"	""	""	""	""	""	""	""	"Membrane"	""	"FALSE"
"9087-8_3"	""	"NHLC3"	"NHL repeat-containing protein 3"	"13"	"39612443"	"39624246"	"NHLRC3"	"ENSG00000188811"	"Q5JS37"	""	""	""	""	""	""	""	"Secreted"	""	"FALSE"
"9088-20_3"	""	"SL9B2"	"Mitochondrial sodium/hydrogen exchanger 9B2"	"4"	"103941025"	"104006986"	"SLC9B2"	"ENSG00000164038"	"Q86UD5"	""	""	""	""	""	""	""	"Na(+)/H(+) antiporter that extrudes Na(+) or Li(+) in exchange for external protons across the membrane (PubMed:18000046, PubMed:28154142, PubMed:22948142, PubMed:18508966). Contributes to the regulation of intracellular pH, sodium homeostasis, and cell volume. Plays an important role for insulin secretion and clathrin-mediated endocytosis in beta-cells (By similarity). Involved in sperm motility and fertility (By similarity). It is controversial whether SLC9B2 plays a role in osteoclast differentiation or not (By similarity)."	""	"FALSE"
"9092-33_3"	""	"ANGL1"	"Angiopoietin-related protein 1"	"1"	"178818840"	"178840187"	"ANGPTL1"	"ENSG00000116194"	"O95841"	""	""	""	""	""	""	""	"Secreted"	""	"FALSE"
"9118-7_3"	""	"PSD2"	"PH and SEC7 domain-containing protein 2"	"5"	"139175406"	"139224051"	"PSD2"	"ENSG00000146005"	"Q9BQI7"	""	""	""	""	""	""	""	"Cell membrane"	""	"FALSE"
"9169-14_3"	""	"SUMO3"	"Small ubiquitin-related modifier 3"	"21"	"46225532"	"46238694"	"SUMO3"	"ENSG00000184900"	"P55854"	""	""	""	""	""	""	""	"Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (PubMed:11451954, PubMed:18538659, PubMed:21965678). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744)."	""	"FALSE"
"9173-21_3"	""	"PGM1"	"Phosphoglucomutase-1"	"1"	"64058947"	"64125916"	"PGM1"	"ENSG00000079739"	"P36871"	""	""	""	""	""	""	""	"This enzyme participates in both the breakdown and synthesis of glucose."	""	"FALSE"
"9176-3_3"	""	"MUC1"	"Mucin-1"	"1"	"155158300"	"155162707"	"MUC1"	"ENSG00000185499"	"P15941"	""	""	""	""	""	""	""	"The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack."	""	"FALSE"
"9177-6_3"	""	"FAM3B"	"Protein FAM3B"	"21"	"42676139"	"42729358"	"FAM3B"	"ENSG00000183844"	"P58499"	""	""	""	""	""	""	""	"Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner."	""	"FALSE"
"9183-7_3"	""	"IFN-a/b R1"	"Interferon alpha/beta receptor 1"	"21"	"34696782"	"34732168"	"IFNAR1"	"ENSG00000142166"	"P17181"	""	""	""	""	""	""	""	"Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:2153461, PubMed:7665574, PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:21854986). Functions in general as heterodimer with IFNAR2 (PubMed:7665574, PubMed:10049744, PubMed:21854986). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (PubMed:7665574, PubMed:21854986). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity)."	""	"FALSE"
"9185-15_3"	""	"TFF1"	"Trefoil factor 1"	"21"	"43782391"	"43786703"	"TFF1"	"ENSG00000160182"	"P04155"	""	""	""	""	""	""	""	"Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine."	""	"FALSE"
"9187-2_3"	""	"HMGN1"	"Non-histone chromosomal protein HMG-14"	"21"	"40714241"	"40721573"	"HMGN1"	"ENSG00000205581"	"P05114"	""	""	""	""	""	""	""	"Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity)."	""	"FALSE"
"9190-7_3"	""	"CD63"	"CD63 antigen"	"12"	"56119107"	"56123491"	"CD63"	"ENSG00000135404"	"P08962"	""	""	""	""	""	""	""	"Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli."	""	"FALSE"
"9196-8_3"	""	"Galectin-7"	"Galectin-7"	"19|19"	"39261611|39279851"	"39264132|39282389"	"LGALS7|LGALS7"	"ENSG00000205076|ENSG00000178934"	"P47929|P47929"	""	""	""	""	""	""	""	"Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release."	""	"FALSE"
"9197-4_3"	""	"LEG9"	"Galectin-9"	"17"	"25956824"	"25976586"	"LGALS9"	"ENSG00000168961"	"O00182"	""	""	""	""	""	""	""	"Binds galactosides (PubMed:18005988). Has high affinity for the Forssman pentasaccharide (PubMed:18005988). Ligand for HAVCR2/TIM3 (PubMed:16286920). Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death (PubMed:16286920). Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth (By similarity). Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T-helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). Ligand for CD44; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity). Promotes ability of mesenchymal stromal cells to suppress T-cell proliferation (PubMed:23817958). Expands regulatory T-cells and induces cytotoxic T-cell apoptosis following virus infection (PubMed:20209097). Activates ERK1/2 phosphorylation inducing cytokine (IL-6, IL-8, IL-12) and chemokine (CCL2) production in mast and dendritic cells (PubMed:24465902, PubMed:16116184). Inhibits degranulation and induces apoptosis of mast cells (PubMed:24465902). Induces maturation and migration of dendritic cells (PubMed:25754930, PubMed:16116184). Inhibits natural killer (NK) cell function (PubMed:23408620). Can transform NK cell phenotype from peripheral to decidual during pregnancy (PubMed:25578313). Astrocyte derived galectin-9 enhances microglial TNF production (By similarity). May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. May provide the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion (By similarity). Highly selective to the anion urate (By similarity)."	""	"FALSE"
"9207-60_3"	""	"QORL1"	"Quinone oxidoreductase-like protein 1"	"21"	"34961647"	"35016232"	"CRYZL1"	"ENSG00000205758"	"O95825"	""	""	""	""	""	""	""	"alternative splicing"	""	"FALSE"
"9211-19_3"	""	"PEDF"	"Pigment epithelium-derived factor"	"17"	"1665253"	"1680868"	"SERPINF1"	"ENSG00000132386"	"P36955"	""	""	""	""	""	""	""	"Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity."	""	"FALSE"
"9212-22_3"	""	"CATF"	"Cathepsin F"	"11"	"66330934"	"66336312"	"CTSF"	"ENSG00000174080"	"Q9UBX1"	""	""	""	""	""	""	""	"Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis."	""	"FALSE"
"9215-117_3"	""	"UBP25"	"Ubiquitin carboxyl-terminal hydrolase 25"	"21"	"17102344"	"17252388"	"USP25"	"ENSG00000155313"	"Q9UHP3"	""	""	""	""	""	""	""	"Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains."	""	"FALSE"
"9216-100_3"	""	"PLXB2"	"Plexin-B2"	"22"	"50713408"	"50746056"	"PLXNB2"	"ENSG00000196576"	"O15031"	""	""	""	""	""	""	""	"Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound-healing assays (in vitro) (By similarity)."	""	"FALSE"
"9220-7_3"	""	"EPHB3"	"Ephrin type-B receptor 3"	"3"	"184279572"	"184300197"	"EPHB3"	"ENSG00000182580"	"P54753"	""	""	""	""	""	""	""	"Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt."	""	"FALSE"
"9221-6_3"	""	"IPIL1"	"Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1"	"2"	"96991069"	"96996255"	"ITPRIPL1"	"ENSG00000198885"	"Q6GPH6"	""	""	""	""	""	""	""	"EBI-953819"	""	"FALSE"
"9227-15_3"	""	"PD-1"	"Programmed cell death protein 1"	"2"	"242792033"	"242801060"	"PDCD1"	"ENSG00000188389"	"Q15116"	""	""	""	""	""	""	""	"Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors."	""	"FALSE"
"9229-9_3"	""	"CTRL"	"Chymotrypsin-like protease CTRL-1"	"16"	"67961543"	"67966317"	"CTRL"	"ENSG00000141086"	"P40313"	""	""	""	""	""	""	""	"Belongs to the peptidase S1 family."	""	"FALSE"
"9231-23_3"	""	"IMPA3"	"Inositol monophosphatase 3"	"8"	"57870492"	"57906403"	"IMPAD1"	"ENSG00000104331"	"Q9NX62"	""	""	""	""	""	""	""	"May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation."	""	"FALSE"
"9237-54_3"	""	"Lysosomal acid phosphatase"	"Lysosomal acid phosphatase"	"11"	"47260853"	"47270457"	"ACP2"	"ENSG00000134575"	"P11117"	""	""	""	""	""	""	""	"A phosphate monoester + H(2)O = an alcohol + phosphate."	""	"FALSE"
"9241-40_3"	""	"SIRPG"	"Signal-regulatory protein gamma"	"20"	"1609798"	"1638425"	"SIRPG"	"ENSG00000089012"	"Q9P1W8"	""	""	""	""	""	""	""	"Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation."	""	"FALSE"
"9243-10_3"	""	"LYG1"	"Lysozyme g-like protein 1"	"2"	"99900701"	"99921205"	"LYG1"	"ENSG00000144214"	"Q8N1E2"	""	""	""	""	""	""	""	"Secreted"	""	"FALSE"
"9244-27_3"	""	"PPT1"	"Palmitoyl-protein thioesterase 1"	"1"	"40538377"	"40563375"	"PPT1"	"ENSG00000131238"	"P50897"	""	""	""	""	""	""	""	"Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons (PubMed:8816748)."	""	"FALSE"
"9251-28_3"	""	"MA2B2"	"Epididymis-specific alpha-mannosidase"	"4"	"6576902"	"6625089"	"MAN2B2"	"ENSG00000013288"	"Q9Y2E5"	""	""	""	""	""	""	""	"Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides."	""	"FALSE"
"9253-52_3"	""	"BGAT"	"Histo-blood group ABO system transferase"	"9"	"136125788"	"136150630"	"ABO"	"ENSG00000175164"	"P16442"	""	""	""	""	""	""	""	"This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity."	""	"FALSE"
"9256-78_3"	""	"NPTX1"	"Neuronal pentraxin-1"	"17"	"78440948"	"78451643"	"NPTX1"	"ENSG00000171246"	"Q15818"	""	""	""	""	""	""	""	"May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses."	""	"FALSE"
"9266-1_3"	""	"sTREM-1"	"Triggering receptor expressed on myeloid cells 1"	"6"	"41235664"	"41254457"	"TREM1"	"ENSG00000124731"	"Q9NP99"	""	""	""	""	""	""	""	"Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock."	""	"FALSE"
"9267-2_3"	""	"CBPA4"	"Carboxypeptidase A4"	"7"	"129932974"	"129964020"	"CPA4"	"ENSG00000128510"	"Q9UI42"	""	""	""	""	""	""	""	"Metalloprotease that could be involved in the histone hyperacetylation pathway (PubMed:10383164). Releases a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val (PubMed:20385563)."	""	"FALSE"
"9271-101_3"	""	"STIM1"	"Stromal interaction molecule 1"	"11"	"3875757"	"4114440"	"STIM1"	"ENSG00000167323"	"Q13586"	""	""	""	""	""	""	""	"Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores (PubMed:15866891, PubMed:16005298, PubMed:16208375, PubMed:16537481, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:18854159, PubMed:19249086, PubMed:22464749, PubMed:24069340, PubMed:24351972, PubMed:24591628, PubMed:26322679, PubMed:25326555, PubMed:28219928). Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit ORAI1 (PubMed:16208375, PubMed:16537481). Involved in enamel formation (PubMed:24621671). Activated following interaction with STIMATE, leading to promote STIM1 conformational switch (PubMed:26322679)."	""	"FALSE"
"9276-7_3"	""	"CBPA2"	"Carboxypeptidase A2"	"7"	"129906667"	"129929638"	"CPA2"	"ENSG00000158516"	"P48052"	""	""	""	""	""	""	""	"Similar to that of carboxypeptidase A (EC 3.4.17.1), but with a preference for bulkier C-terminal residues."	""	"FALSE"
"9278-9_3"	""	"Epiphycan"	"Epiphycan"	"12"	"91357456"	"91398803"	"EPYC"	"ENSG00000083782"	"Q99645"	""	""	""	""	""	""	""	"May have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization."	""	"FALSE"
"9282-12_3"	""	"CRIS2"	"Cysteine-rich secretory protein 2"	"6"	"49660071"	"49681303"	"CRISP2"	"ENSG00000124490"	"P16562"	""	""	""	""	""	""	""	"May regulate some ion channels' activity and therebye regulate calcium fluxes during sperm capacitation."	""	"FALSE"
"9288-7_3"	""	"FKBP7"	"Peptidyl-prolyl cis-trans isomerase FKBP7"	"2"	"179328391"	"179343327"	"FKBP7"	"ENSG00000079150"	"Q9Y680"	""	""	""	""	""	""	""	"PPIases accelerate the folding of proteins during protein synthesis."	""	"FALSE"
"9294-45_3"	""	"MFAP2"	"Microfibrillar-associated protein 2"	"1"	"17300997"	"17307330"	"MFAP2"	"ENSG00000117122"	"P55001"	""	""	""	""	""	""	""	"Component of the elastin-associated microfibrils."	""	"FALSE"
"9297-12_3"	""	"B3GN8"	"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8"	"19"	"41931264"	"41934635"	"B3GNT8"	"ENSG00000177191"	"Q7Z7M8"	""	""	""	""	""	""	""	"Beta-1,3-N-acetylglucosaminyltransferase that plays a role in the elongation of specific branch structures of multiantennary N-glycans. Has strong activity towards tetraantennary N-glycans and 2,6 triantennary glycans."	""	"FALSE"
"9302-90_3"	""	"G45IP"	"Growth arrest and DNA damage-inducible proteins-interacting protein 1"	"19"	"13063933"	"13068050"	"GADD45GIP1"	"ENSG00000179271"	"Q8TAE8"	""	""	""	""	""	""	""	"Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis."	""	"FALSE"
"9303-9_3"	""	"B7-H2"	"ICOS ligand"	"21|21"	"45642874|45642879"	"45660849|45660886"	"ICOSLG|ICOSLG"	"ENSG00000160223|ENSG00000277117"	"O75144|O75144"	""	""	""	""	""	""	""	"Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity)."	""	"FALSE"
"9312-8_3"	""	"AZGP1"	"Zinc-alpha-2-glycoprotein"	"7"	"99564343"	"99573780"	"AZGP1"	"ENSG00000160862"	"P25311"	""	""	""	""	""	""	""	"Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids."	""	"FALSE"
"9313-27_3"	""	"CBLN1"	"Cerebellin-1"	"16"	"49311828"	"49315742"	"CBLN1"	"ENSG00000102924"	"P23435"	""	""	""	""	""	""	""	"Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the matching and maintenance of pre- and post-synaptic elements at parallel fiber-Purkinje cell synapses, the establishment of the proper pattern of climbing fiber-Purkinje cell innervation, and induction of long-term depression at parallel fiber-Purkinje cell synapses. Plays a role as a synaptic organizer that acts bidirectionally on both pre- and post-synaptic components. On the one hand induces accumulation of synaptic vesicles in the pre-synaptic part by binding with NRXN1 and in other hand induces clustering of GRID2 and its associated proteins at the post-synaptic site through association of GRID2. NRXN1-CBLN1-GRID2 complex directly induces parallel fiber protrusions that encapsulate spines of Purkinje cells leading to accumulation of GRID2 and synaptic vesicles. Required for CBLN3 export from the endoplasmic reticulum and secretion (By similarity). NRXN1-CBLN1-GRID2 complex mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis (PubMed:27418511)."	""	"FALSE"
"9314-9_3"	""	"PSG5"	"Pregnancy-specific beta-1-glycoprotein 5"	"19"	"43670408"	"43690688"	"PSG5"	"ENSG00000204941"	"Q15238"	""	""	""	""	""	""	""	"EBI-4314891"	""	"FALSE"
"9315-16_3"	""	"MUL1"	"Mitochondrial ubiquitin ligase activator of NFKB 1"	"1"	"20825941"	"20834654"	"MUL1"	"ENSG00000090432"	"Q969V5"	""	""	""	""	""	""	""	"Exhibits weak E3 ubiquitin-protein ligase activity (PubMed:18591963, PubMed:19407830, PubMed:22410793). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:18591963, PubMed:19407830, PubMed:22410793). Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation (PubMed:22410793). Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations (PubMed:19407830). Plays a role in the control of mitochondrial morphology by promoting mitchondrial fragmentation, and influences mitochondrial localization (PubMed:19407830, PubMed:18207745, PubMed:18213395). Likely to promote mitchondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is parallel to the PRKN/PINK1 regulatory pathway (PubMed:24898855). May also be involved in the sumoylation of the membrane fission protein DNM1L (PubMed:18207745, PubMed:19407830). Inhibits cell growth (PubMed:18591963, PubMed:22410793). When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis (PubMed:23399697). Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response (PubMed:23399697). Can mediate DDX58 sumoylation and disrupt its polyubiquitination (PubMed:23399697)."	""	"FALSE"
"9335-28_3"	""	"PSG9"	"Pregnancy-specific beta-1-glycoprotein 9"	"19"	"43715943"	"43773682"	"PSG9"	"ENSG00000183668"	"Q00887"	""	""	""	""	""	""	""	"Secreted"	""	"FALSE"
"9337-43_3"	""	"TKN1"	"Protachykinin-1"	"7"	"97361220"	"97369784"	"TAC1"	"ENSG00000006128"	"P20366"	""	""	""	""	""	""	""	"Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles."	""	"FALSE"
"9338-2_3"	""	"DCBD2"	"Discoidin, CUB and LCCL domain-containing protein 2"	"3"	"98514785"	"98620533"	"DCBLD2"	"ENSG00000057019"	"Q96PD2"	""	""	""	""	""	""	""	"EBI-8536103"	""	"FALSE"
"9340-17_3"	""	"FKB14"	"Peptidyl-prolyl cis-trans isomerase FKBP14"	"7"	"30050203"	"30066300"	"FKBP14"	"ENSG00000106080"	"Q9NWM8"	""	""	""	""	""	""	""	"PPIase which accelerates the folding of proteins during protein synthesis. Has a preference for substrates containing 4-hydroxylproline modifications, including type III collagen. May also target type VI and type X collagens."	""	"FALSE"
"9341-1_3"	""	"PDGFD"	"Platelet-derived growth factor D"	"11"	"103777914"	"104035107"	"PDGFD"	"ENSG00000170962"	"Q9GZP0"	""	""	""	""	""	""	""	"Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity)."	""	"FALSE"
"9348-1_3"	""	"C1RL1"	"Complement C1r subcomponent-like protein"	"12"	"7242183"	"7261869"	"C1RL"	"ENSG00000139178"	"Q9NZP8"	""	""	""	""	""	""	""	"Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum."	""	"FALSE"
"9350-3_3"	""	"FSTL4"	"Follistatin-related protein 4"	"5"	"132532147"	"132948255"	"FSTL4"	"ENSG00000053108"	"Q6MZW2"	""	""	""	""	""	""	""	"Secreted"	""	"FALSE"
"9357-4_3"	""	"CREG1"	"Protein CREG1"	"1"	"167498914"	"167523004"	"CREG1"	"ENSG00000143162"	"O75629"	""	""	""	""	""	""	""	"May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R."	""	"FALSE"
"9370-69_3"	""	"GGH"	"Gamma-glutamyl hydrolase"	"8"	"63927638"	"63951730"	"GGH"	"ENSG00000137563"	"Q92820"	""	""	""	""	""	""	""	"Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates."	""	"FALSE"
"9377-25_3"	""	"SCF"	"Kit ligand"	"12"	"88886570"	"88974628"	"KITLG"	"ENSG00000049130"	"P21583"	""	""	""	""	""	""	""	"Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins."	""	"FALSE"
"9380-2_3"	""	"sPLA(2)-XIII"	"Group XIIB secretory phospholipase A2-like protein"	"10"	"74694928"	"74714536"	"PLA2G12B"	"ENSG00000138308"	"Q9BX93"	""	""	""	""	""	""	""	"Not known; does not seem to have catalytic activity."	""	"FALSE"
"9383-24_3"	""	"CH3L2"	"Chitinase-3-like protein 2"	"1"	"111743393"	"111786062"	"CHI3L2"	"ENSG00000064886"	"Q15782"	""	""	""	""	""	""	""	"Lectin that binds chitooligosaccharides and other glycans with high affinity, but not heparin. Has no chitinase activity."	""	"FALSE"
"9387-13_3"	""	"CL049"	"UPF0454 protein C12orf49"	"12"	"117147990"	"117175875"	"C12orf49"	"ENSG00000111412"	"Q9H741"	""	""	""	""	""	""	""	"EBI-2836158"	""	"FALSE"
"9398-30_3"	""	"GALP"	"Galanin-like peptide"	"19"	"56687389"	"56697144"	"GALP"	"ENSG00000197487"	"Q9UBC7"	""	""	""	""	""	""	""	"Isoform 1: Hypothalamic neuropeptide which binds to the G-protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion."	""	"FALSE"
"9459-7_3"	""	"Fas, soluble"	"Tumor necrosis factor receptor superfamily member 6"	"10"	"90750288"	"90775542"	"FAS"	"ENSG00000026103"	"P25445"	""	""	""	""	""	""	""	"Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro)."	""	"FALSE"
"9482-110_3"	""	"NUDT9"	"ADP-ribose pyrophosphatase, mitochondrial"	"4"	"88343734"	"88380606"	"NUDT9"	"ENSG00000170502"	"Q9BW91"	""	""	""	""	""	""	""	"Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate."	""	"FALSE"
"9484-75_3"	""	"Desmoglein-2"	"Desmoglein-2"	"18"	"29078006"	"29128971"	"DSG2"	"ENSG00000046604"	"Q14126"	""	""	""	""	""	""	""	"Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion."	""	"FALSE"
"9506-10_3"	""	"Apo L1"	"Apolipoprotein L1"	"22"	"36649056"	"36663576"	"APOL1"	"ENSG00000100342"	"O14791"	""	""	""	""	""	""	""	"May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver."	""	"FALSE"
"9544-24_3"	""	"CG069"	"Uncharacterized protein C7orf69"	"7"	"47834889"	"47859445"	"C7orf69"	"ENSG00000136275"	"Q9H7B7"	""	""	""	""	""	""	""	"Secreted"	""	"FALSE"
"9545-156_3"	""	"Granzyme K"	"Granzyme K"	"5"	"54320081"	"54330398"	"GZMK"	"ENSG00000113088"	"P49863"	""	""	""	""	""	""	""	"Secreted"	""	"FALSE"
"9557-5_3"	""	"MANS1"	"MANSC domain-containing protein 1"	"12"	"12478990"	"12503475"	"MANSC1"	"ENSG00000111261"	"Q9H8J5"	""	""	""	""	""	""	""	"Membrane"	""	"FALSE"
"9578-263_3"	""	"MANS4"	"MANSC domain-containing protein 4"	"12"	"27915671"	"27924209"	"MANSC4"	"ENSG00000205693"	"A6NHS7"	""	""	""	""	""	""	""	"Membrane"	""	"FALSE"
"9580-5_3"	""	"Laminin gamma-2"	"Laminin subunit gamma-2"	"1"	"183155373"	"183214035"	"LAMC2"	"ENSG00000058085"	"Q13753"	""	""	""	""	""	""	""	"Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Ladsin exerts cell-scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells."	""	"FALSE"
"9584-105_3"	""	"RMTL1"	"rRNA methyltransferase 3, mitochondrial"	"17"	"685513"	"695749"	"RNMTL1"	"ENSG00000171861"	"Q9HC36"	""	""	""	""	""	""	""	"S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1370 (Gm1370) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA."	""	"FALSE"
"9595-11_3"	""	"B4GT2"	"Beta-1,4-galactosyltransferase 2"	"1"	"44444615"	"44456842"	"B4GALT2"	"ENSG00000117411"	"O60909"	""	""	""	""	""	""	""	"Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Can produce lactose."	""	"FALSE"
"9598-23_3"	""	"CSMD1"	"CUB and sushi domain-containing protein 1"	"8"	"2792875"	"4852494"	"CSMD1"	"ENSG00000183117"	"Q96PZ7"	""	""	""	""	""	""	""	"Potential suppressor of squamous cell carcinomas."	""	"FALSE"
"9599-6_3"	""	"PIANP"	"PILR alpha-associated neural protein"	"12"	"6802958"	"6809966"	"PIANP"	"ENSG00000139200"	"Q8IYJ0"	""	""	""	""	""	""	""	"Acts as a ligand for PILRA in neural tissues, where it may be involved in immune regulation."	""	"FALSE"
"9613-16_3"	""	"CH033"	"UPF0488 protein C8orf33"	"8"	"146277764"	"146281416"	"C8orf33"	"ENSG00000182307"	"Q9H7E9"	""	""	""	""	""	""	""	"EBI-715389"	""	"FALSE"
"9713-67_3"	""	"PGFRL"	"Platelet-derived growth factor receptor-like protein"	"8"	"17433942"	"17501580"	"PDGFRL"	"ENSG00000104213"	"Q15198"	""	""	""	""	""	""	""	"Forms a complex composed of PDGFRL, TNK2 and GRB2."	""	"FALSE"
"9723-105_3"	""	"EMILIN-3"	"Multimerin-2"	"10"	"88695297"	"88729238"	"MMRN2"	"ENSG00000173269"	"Q9H8L6"	""	""	""	""	""	""	""	"Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it downregulates KDR activation by binding VEGFA."	""	"FALSE"
"9735-44_3"	""	"TACT"	"T-cell surface protein tactile"	"3"	"111011566"	"111384597"	"CD96"	"ENSG00000153283"	"P40200"	""	""	""	""	""	""	""	"May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation."	""	"FALSE"
"9742-59_3"	""	"BAT1"	"Spliceosome RNA helicase DDX39B"	"6"	"31497996"	"31510225"	"DDX39B"	"ENSG00000198563"	"Q13838"	""	""	""	""	""	""	""	"Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC and CHTOP onto mRNA. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Also associates with pre-mRNA independent of ALYREF/THOC4 and the THO complex. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability."	""	"FALSE"
"9745-20_3"	""	"IF4E2"	"Eukaryotic translation initiation factor 4E type 2"	"2"	"233414762"	"233448354"	"EIF4E2"	"ENSG00000135930"	"O60573"	""	""	""	""	""	""	""	"Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation (PubMed:9582349, PubMed:17368478, PubMed:25624349). Acts as a repressor of translation initiation (PubMed:22751931). In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap (By similarity)."	""	"FALSE"
"9749-190_3"	""	"L-plastin"	"Plastin-2"	"13"	"46700055"	"46786006"	"LCP1"	"ENSG00000136167"	"P13796"	""	""	""	""	""	""	""	"Actin-binding protein (PubMed:16636079, PubMed:17294403, PubMed:28493397). Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28 (PubMed:17294403). Modulates the cell surface expression of IL2RA/CD25 and CD69 (PubMed:17294403)."	""	"FALSE"
"9753-17_3"	""	"Ezrin"	"Ezrin"	"6"	"159186773"	"159240444"	"EZR"	"ENSG00000092820"	"P15311"	""	""	""	""	""	""	""	"Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis."	""	"FALSE"
"9754-33_3"	""	"Quinone reductase 2"	"Ribosyldihydronicotinamide dehydrogenase [quinone]"	"6"	"2988221"	"3029103"	"NQO2"	"ENSG00000124588"	"P16083"	""	""	""	""	""	""	""	"The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis."	""	"FALSE"
"9758-17_3"	""	"RS4X"	"40S ribosomal protein S4, X isoform"	"X"	"71475529"	"71497150"	"RPS4X"	"ENSG00000198034"	"P62701"	""	""	""	""	""	""	""	"Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs."	""	"FALSE"
"9759-13_3"	""	"INDO"	"Indoleamine 2,3-dioxygenase 1"	"8"	"39759794"	"39785963"	"IDO1"	"ENSG00000131203"	"P14902"	""	""	""	""	""	""	""	"Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses (PubMed:25691885). Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells (PubMed:25691885). Acts as a suppressor of anti-tumor immunity (PubMed:23103127, PubMed:25157255, PubMed:14502282, PubMed:25691885). Limits the growth of intracellular pathogens by depriving tryptophan (PubMed:25691885). Protects the fetus from maternal immune rejection (PubMed:25691885)."	""	"FALSE"
"9789-52_3"	""	"Nesprin-2"	"Nesprin-2"	"14"	"64319701"	"64693151"	"SYNE2"	"ENSG00000054654"	"Q8WXH0"	""	""	""	""	""	""	""	"Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis."	""	"FALSE"
"9793-145_3"	""	"IGDC4"	"Immunoglobulin superfamily DCC subclass member 4"	"15"	"65673802"	"65715410"	"IGDCC4"	"ENSG00000103742"	"Q8TDY8"	""	""	""	""	""	""	""	"Cell membrane"	""	"FALSE"
"9796-4_3"	""	"CEL"	"Bile salt-activated lipase"	"9"	"135937365"	"135962742"	"CEL"	"ENSG00000170835"	"P19835"	""	""	""	""	""	""	""	"Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides."	""	"FALSE"
"9804-11_3"	""	"CO9A2"	"Collagen alpha-2(IX) chain"	"1"	"40766159"	"40783488"	"COL9A2"	"ENSG00000049089"	"Q14055"	""	""	""	""	""	""	""	"Structural component of hyaline cartilage and vitreous of the eye."	""	"FALSE"
"9816-37_3"	""	"ISOC1"	"Isochorismatase domain-containing protein 1"	"5"	"128430444"	"128449721"	"ISOC1"	"ENSG00000066583"	"Q96CN7"	""	""	""	""	""	""	""	"EBI-2805787"	""	"FALSE"
"9823-2_3"	""	"DYR"	"Dihydrofolate reductase"	"5"	"79922047"	"79950802"	"DHFR"	"ENSG00000228716"	"P00374"	""	""	""	""	""	""	""	"Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2."	""	"FALSE"
"9826-135_3"	""	"Fragile histidine triad protein"	"Bis(5'-adenosyl)-triphosphatase"	"3"	"59735036"	"61237133"	"FHIT"	"ENSG00000189283"	"P49789"	""	""	""	""	""	""	""	"Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca(2+) transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor."	""	"FALSE"
"9834-62_3"	""	"ADH1B"	"Alcohol dehydrogenase 1B"	"4"	"100226121"	"100242599"	"ADH1B"	"ENSG00000196616"	"P00325"	""	""	""	""	""	""	""	"A primary alcohol + NAD(+) = an aldehyde + NADH."	""	"FALSE"
"9836-20_3"	""	"DCK"	"Deoxycytidine kinase"	"4"	"71858255"	"71896631"	"DCK"	"ENSG00000156136"	"P27707"	""	""	""	""	""	""	""	"Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents."	""	"FALSE"
"9837-60_3"	""	"NAD(P)H dehydrogenase"	"NAD(P)H dehydrogenase [quinone] 1"	"16"	"69740899"	"69760854"	"NQO1"	"ENSG00000181019"	"P15559"	""	""	""	""	""	""	""	"The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis."	""	"FALSE"
"9839-148_3"	""	"Tirap"	"Toll/interleukin-1 receptor domain-containing adapter protein"	"11"	"126152960"	"126168740"	"TIRAP"	"ENSG00000150455"	"P58753"	""	""	""	""	""	""	""	"Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6."	""	"FALSE"
"9846-32_3"	""	"Rho-GDI beta"	"Rho GDP-dissociation inhibitor 2"	"12"	"15094951"	"15114662"	"ARHGDIB"	"ENSG00000111348"	"P52566"	""	""	""	""	""	""	""	"Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (PubMed:8356058, PubMed:7512369). Regulates reorganization of the actin cytoskeleton mediated by Rho family members (PubMed:8262133)."	""	"FALSE"
"9848-22_3"	""	"Cyclin H"	"Cyclin-H"	"5"	"86687311"	"86708836"	"CCNH"	"ENSG00000134480"	"P51946"	""	""	""	""	""	""	""	"Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle."	""	"FALSE"
"9849-13_3"	""	"APEX1"	"DNA-(apurinic or apyrimidinic site) lyase"	"14"	"20923350"	"20925931"	"APEX1"	"ENSG00000100823"	"P27695"	""	""	""	""	""	""	""	"Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Does also incise at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules. Has a 3'-5' exoribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER. Possesses a DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate) blocking the 3' side of DNA strand breaks. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB. Plays a role in the protection from granzymes-mediated cellular repair leading to cell death. Also involved in the DNA cleavage step of class switch recombination (CSR). On the other hand, APEX1 also exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR. Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs). Together with HNRNPL or the dimer XRCC5/XRCC6, associates with nCaRE, acting as an activator of transcriptional repression. Stimulates the YBX1-mediated MDR1 promoter activity, when acetylated at Lys-6 and Lys-7, leading to drug resistance. Acts also as an endoribonuclease involved in the control of single-stranded RNA metabolism. Plays a role in regulating MYC mRNA turnover by preferentially cleaving in between UA and CA dinucleotides of the MYC coding region determinant (CRD). In association with NMD1, plays a role in the rRNA quality control process during cell cycle progression. Associates, together with YBX1, on the MDR1 promoter. Together with NPM1, associates with rRNA. Binds DNA and RNA."	""	"FALSE"
"9850-38_3"	""	"IF1AX"	"Eukaryotic translation initiation factor 1A, X-chromosomal"	"X"	"20142636"	"20159962"	"EIF1AX"	"ENSG00000173674"	"P47813"	""	""	""	""	""	""	""	"Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits."	""	"FALSE"
"9854-36_3"	""	"Aldose reductase"	"Aldose reductase"	"7"	"134127102"	"134144036"	"AKR1B1"	"ENSG00000085662"	"P15121"	""	""	""	""	""	""	""	"Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies."	""	"FALSE"
"9855-10_3"	""	"Rho A"	"Transforming protein RhoA"	"3"	"49396578"	"49450431"	"RHOA"	"ENSG00000067560"	"P61586"	""	""	""	""	""	""	""	"Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity). Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis (PubMed:9635436, PubMed:19403695)."	""	"FALSE"
"9877-28_3"	""	"CRKL"	"Crk-like protein"	"22"	"21271714"	"21308037"	"CRKL"	"ENSG00000099942"	"P46109"	""	""	""	""	""	""	""	"May mediate the transduction of intracellular signals."	""	"FALSE"
"9878-3_3"	""	"SULT 1E"	"Estrogen sulfotransferase"	"4"	"70676498"	"70725870"	"SULT1E1"	"ENSG00000109193"	"P49888"	""	""	""	""	""	""	""	"Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by metabolizing free estradiol. Maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. Also sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol, at significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated."	""	"FALSE"
"9884-8_3"	""	"PPIL1"	"Peptidyl-prolyl cis-trans isomerase-like 1"	"6"	"36822603"	"36842800"	"PPIL1"	"ENSG00000137168"	"Q9Y3C6"	""	""	""	""	""	""	""	"Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346). PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:16595688)."	""	"FALSE"
"9886-28_3"	""	"XRCC4"	"DNA repair protein XRCC4"	"5"	"82373317"	"82649606"	"XRCC4"	"ENSG00000152422"	"Q13426"	""	""	""	""	""	""	""	"Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends."	""	"FALSE"
"9906-21_3"	""	"TICN3"	"Testican-3"	"4"	"167654535"	"168155947"	"SPOCK3"	"ENSG00000196104"	"Q9BQ16"	""	""	""	""	""	""	""	"May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion."	""	"FALSE"
"9918-23_3"	""	"Calbindin D28"	"Calbindin"	"8"	"91070836"	"91107703"	"CALB1"	"ENSG00000104327"	"P05937"	""	""	""	""	""	""	""	"Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase."	""	"FALSE"
"9927-96_3"	""	"TENS4"	"Tensin-4"	"17"	"38632080"	"38657849"	"TNS4"	"ENSG00000131746"	"Q8IZW8"	""	""	""	""	""	""	""	"May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3."	""	"FALSE"
"9937-7_3"	""	"CXA1"	"Gap junction alpha-1 protein"	"6"	"121756838"	"121770873"	"GJA1"	"ENSG00000152661"	"P17302"	""	""	""	""	""	""	""	"Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity)."	""	"FALSE"
"9942-2_3"	""	"NXT1"	"NTF2-related export protein 1"	"20"	"23331373"	"23335414"	"NXT1"	"ENSG00000132661"	"Q9UKK6"	""	""	""	""	""	""	""	"Stimulator of protein export for NES-containing proteins (PubMed:10567585). Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (PubMed:10848583). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 (PubMed:19165146, PubMed:11259602)."	""	"FALSE"
"9954-2_3"	""	"NPPL3"	"Nuclear pore complex-interacting protein family member B3"	"16"	"21413558"	"21459888"	"NPIPB3"	"ENSG00000169246"	"Q92617"	""	""	""	""	""	""	""	"Membrane"	""	"FALSE"
"9959-60_3"	""	"TM59L"	"Transmembrane protein 59-like"	"19"	"18718240"	"18731849"	"TMEM59L"	"ENSG00000105696"	"Q9UK28"	""	""	""	""	""	""	""	"Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding."	""	"FALSE"
"9962-1_3"	""	"MUCDL"	"Cadherin-related family member 5"	"11"	"616565"	"626078"	"CDHR5"	"ENSG00000099834"	"Q9HBB8"	""	""	""	""	""	""	""	"Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR2 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation."	""	"FALSE"
"9963-19_3"	""	"PCDBA"	"Protocadherin beta-10"	"5"	"140566893"	"140575215"	"PCDHB10"	"ENSG00000120324"	"Q9UN67"	""	""	""	""	""	""	""	"Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain."	""	"FALSE"
"9969-8_3"	""	"S22AG"	"Solute carrier family 22 member 16"	"6"	"110745890"	"110797844"	"SLC22A16"	"ENSG00000004809"	"Q86VW1"	""	""	""	""	""	""	""	"High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The uptake of TEA is inhibited by various organic cations. The uptake of doxorubicin is sodium-independent."	""	"FALSE"
"9971-5_3"	""	"CSMD2"	"CUB and sushi domain-containing protein 2"	"1"	"33979599"	"34631443"	"CSMD2"	"ENSG00000121904"	"Q7Z408"	""	""	""	""	""	""	""	"Cell membrane"	""	"FALSE"
"9986-14_3"	""	"Neuropeptide W"	"Neuropeptide W"	"16"	"2059927"	"2070756"	"NPW"	"ENSG00000183971"	"Q8N729"	""	""	""	""	""	""	""	"Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30."	""	"FALSE"
"9994-217_3"	""	"ATP4B"	"Potassium-transporting ATPase subunit beta"	"13"	"114303119"	"114312501"	"ATP4B"	"ENSG00000186009"	"P51164"	""	""	""	""	""	""	""	"Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity."	""	"FALSE"