HelmholtzZentrum munich
WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 128

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
SREC-I cis Discovery rs8071756 17:1,574,342 A/G 0.22 997 0.590 0.049 9.4×10-31 1.090 2.6×10-31 7.9×10-31
SREC-I cis Replication rs16951086 17:1,578,748 A/G 0.21 337 0.200 0.058 0.001 1.060 1.3×10-4 0.001

 

Regional association plots

Scavenger receptor class F member 1 (SREC-I)

Download the association data used to generate this plot

 

Boxplots and histograms for top associations

Scavenger receptor class F member 1 (SREC-I)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Scavenger receptor class F member 1 (SREC-I)

Target (abbrv.) SREC-I
Target (full name) Scavenger receptor class F member 1
Somalogic ID (Sequence ID) SL005221 (5129-12_3)
Entrez Gene Symbol SCARF1
UniProt ID Q14162
UniProt Comment
  • Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity).
Reactome
  • Scavenging by Class F Receptors

All locus annotations are based on the sentinel SNP (rs8071756) and 13 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by