Connecting genetic risk to disease endpoints through the human blood plasma proteome
ONLINE SUPPLEMENTARY INFORMATION
Locus annotations
Locus 132
Top associations per target
| Target | cis/trans | Study | SNP | SNP location | Maj/min allele | MAF | N | βinv | seinv | Pinv | fclog | Plog | Praw |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MMP-8 | trans | Discovery | rs2736186 | 6:31,572,333 | G/A | 0.04 | 995 | 1.233 | 0.105 | 1.1×10-29 | 1.490 | 5.5×10-32 | 2.9×10-27 |
Regional association plots
Neutrophil collagenase (MMP-8)
Boxplots and histograms for top associations
Neutrophil collagenase (MMP-8)
| inverse-normalized probe levels | log2 transformed probe levels | raw probe levels | |
|---|---|---|---|
| Discovery study |
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Neutrophil collagenase (MMP-8)
| Target (abbrv.) | MMP-8 |
| Target (full name) | Neutrophil collagenase |
| Somalogic ID (Sequence ID) | SL000526 (2954-56_2) |
| Entrez Gene Symbol | MMP8 |
| UniProt ID | P22894 |
| UniProt Comment |
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| Targeted by drugs (based on IPA annotation) |
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| Biomarker applications (based on IPA annotation) |
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All locus annotations are based on the sentinel SNP (rs2736186).
Download the detailed results of SNiPA's block annotation (PDF)