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Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 156

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
PPID cis Discovery rs8396 4:159,630,817 T/C 0.29 988 0.501 0.046 3.4×10-26 1.250 5.1×10-23 1.3×10-29
PPID cis Replication rs55936281 4:159,648,596 G/A 0.20 337 0.126 0.049 0.01 1.120 0.064 1.2×10-9

 

Regional association plots

Peptidyl-prolyl cis-trans isomerase D (PPID)

Download the association data used to generate this plot

 

Boxplots and histograms for top associations

Peptidyl-prolyl cis-trans isomerase D (PPID)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Peptidyl-prolyl cis-trans isomerase D (PPID)

Target (abbrv.) PPID
Target (full name) Peptidyl-prolyl cis-trans isomerase D
Somalogic ID (Sequence ID) SL007373 (5202-4_3)
Entrez Gene Symbol PPID
UniProt ID Q08752
UniProt Comment
  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines. May be involved in hepatitis C virus (HCV) replication and release.
Pathway Interaction Database
  • C-MYB transcription factor network

All locus annotations are based on the sentinel SNP (rs8396) and 15 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
  • ETFDH electron-transferring-flavoprotein dehydrogenase
  • U3
  • PPID peptidylprolyl isomerase D