Locus 175

GWAS results
Target annotations
Locus annotations
Network

Top associations per target

Target	cis/trans	Study	SNP	SNP location	Maj/min allele	MAF	N	β_inv	se_inv	P_inv	fc_log	P_log	P_raw
MICA	cis	Discovery	rs2516470	6:31,407,331	C/G	0.35	995	0.441	0.043	4.5×10^-23	1.460	1×10^-34	1.3×10^-14

Regional association plots

MHC class I polypeptide-related sequence A (MICA)

Download the association data used to generate this plot

Boxplots and histograms for top associations

MHC class I polypeptide-related sequence A (MICA)

	inverse-normalized probe levels	log₂ transformed probe levels	raw probe levels
Discovery study

MHC class I polypeptide-related sequence A (MICA)

Target (abbrv.)	MICA
Target (full name)	MHC class I polypeptide-related sequence A
Somalogic ID (Sequence ID)	SL005199 (2730-58_2)
Entrez Gene Symbol	MICA
UniProt ID	Q29983
UniProt Comment	Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Biomarker applications (based on IPA annotation)	safety
Pathway Studio	Natural Killer Cell Activation Natural Killer Cell Activation through C-type Lectin-like Receptors

All locus annotations are based on the sentinel SNP (rs2516470).
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by

LINC01149 long intergenic non-protein coding RNA 1149
HCP5 HLA complex P5 (non-protein coding)