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WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 182

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
RAP trans Discovery rs17220241 6:32,822,244 G/T 0.02 997 1.387 0.141 9.6×10-22 2.050 1.8×10-58 4.6×10-55
RAP trans Replication rs16871037 6:32,819,225 C/G 0.05 337 0.540 0.122 1.3×10-5 1.300 2.3×10-7 1.8×10-6

 

Regional association plots

alpha-2-macroglobulin receptor-associated protein (RAP)

Download the association data used to generate this plot

 

Boxplots and histograms for top associations

alpha-2-macroglobulin receptor-associated protein (RAP)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

alpha-2-macroglobulin receptor-associated protein (RAP)

Target (abbrv.) RAP
Target (full name) alpha-2-macroglobulin receptor-associated protein
Somalogic ID (Sequence ID) SL005263 (3640-14_3)
Entrez Gene Symbol LRPAP1
UniProt ID P30533
UniProt Comment
  • Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330.
Pathway Interaction Database
  • Lissencephaly gene (LIS1) in neuronal migration and development
  • Reelin signaling pathway
  • Signaling events mediated by the Hedgehog family

All locus annotations are based on the sentinel SNP (rs17220241) and 13 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
  • TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
  • PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
  • PSMB8-AS1 PSMB8 antisense RNA 1 (head to head)
  • XXbac-BPG246D15.9
  • TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
  • PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
  • HLA-Z major histocompatibility complex, class I, Z (pseudogene)
Potentially regulated genes