Locus 187

GWAS results
Target annotations
Locus annotations
Network

Top associations per target

Target	cis/trans	Study	SNP	SNP location	Maj/min allele	MAF	N	β_inv	se_inv	P_inv	fc_log	P_log	P_raw
IP-10	cis	Discovery	rs11548618	4:76,943,947	G/A	0.01	997	1.841	0.191	4.9×10^-21	2.790	7.2×10^-36	1.4×10^-4

Regional association plots

C-X-C motif chemokine 10 (IP-10)

Download the association data used to generate this plot

Boxplots and histograms for top associations

C-X-C motif chemokine 10 (IP-10)

	inverse-normalized probe levels	log₂ transformed probe levels	raw probe levels
Discovery study

C-X-C motif chemokine 10 (IP-10)

Target (abbrv.)	IP-10
Target (full name)	C-X-C motif chemokine 10
Somalogic ID (Sequence ID)	SL003183 (4141-79_1)
Entrez Gene Symbol	CXCL10
UniProt ID	P02778
UniProt Comment	Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3.
Targeted by drugs (based on IPA annotation)	MDX-1100
Biomarker applications (based on IPA annotation)	diagnosis efficacy unspecified application
Wiki Pathways	Regulation of toll-like receptor signaling pathway Toll-like receptor signaling pathway Type II interferon signaling (IFNG)
Pathway Interaction Database	CXCR3-mediated signaling events
Reactome	Chemokine receptors bind chemokines G alpha (i) signalling events
Pathway Studio	Nociception-related CCR1 expression targets Summarized nociception-related expression targets

All locus annotations are based on the sentinel SNP (rs11548618).
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by

ART3 ADP-ribosyltransferase 3
CXCL10 chemokine (C-X-C motif) ligand 10