HelmholtzZentrum munich
WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 188

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
CLM6 trans Discovery rs10858881 12:89,891,474 T/G 0.22 996 -0.501 0.052 5.1×10-21 -1.110 4.4×10-19 3.1×10-12
CLM6 trans Replication rs10858897 12:89,922,032 C/A 0.30 337 -0.243 0.065 2.1×10-4 -1.070 0.001 0.013

 

Regional association plots

 

Boxplots and histograms for top associations

CMRF35-like molecule 6 (CLM6)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

CMRF35-like molecule 6 (CLM6)

Target (abbrv.) CLM6
Target (full name) CMRF35-like molecule 6
Somalogic ID (Sequence ID) SL014270 (5066-134_3)
Entrez Gene Symbol CD300C
UniProt ID Q08708
UniProt Comment
  • Cell membrane

All locus annotations are based on the sentinel SNP (rs10858881) and 75 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by