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WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 190

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
Fucosyltransferase 3 cis Discovery rs28362459 19:5,844,792 A/C 0.10 987 -0.676 0.071 1.1×10-20 -1.230 3.4×10-12 0.327
Fucosyltransferase 3 cis Replication rs3760775 19:5,841,356 C/A 0.14 337 -0.630 0.097 2.9×10-10 -1.210 1.9×10-4 0.055

 

Regional association plots

Galactoside 3(4)-L-fucosyltransferase (Fucosyltransferase 3)

Download the association data used to generate this plot

 

Boxplots and histograms for top associations

Galactoside 3(4)-L-fucosyltransferase (Fucosyltransferase 3)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Galactoside 3(4)-L-fucosyltransferase (Fucosyltransferase 3)

Target (abbrv.) Fucosyltransferase 3
Target (full name) Galactoside 3(4)-L-fucosyltransferase
Somalogic ID (Sequence ID) SL005575 (4548-4_2)
Entrez Gene Symbol FUT3
UniProt ID P21217
UniProt Comment
  • May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination; Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links.
UniPathway
  • protein glycosylation
Pathway Studio
  • Lacto- and neolacto-type glycosphingolipid biosynthesis

All locus annotations are based on the sentinel SNP (rs28362459).
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
  • FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
  • AC024592.9