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WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 204

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
GFRa-2 cis Discovery rs4443656 8:21,541,084 A/G 0.42 996 0.403 0.044 2.2×10-19 1.080 2.6×10-19 5.8×10-19
GFRa-2 cis Replication rs4443656 8:21,541,084 G/A 0.39 337 -0.318 0.058 7×10-8 -1.060 9.2×10-8 5.1×10-7

 

Regional association plots

GDNF family receptor alpha-2 (GFRa-2)

Download the association data used to generate this plot

 

Boxplots and histograms for top associations

GDNF family receptor alpha-2 (GFRa-2)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

GDNF family receptor alpha-2 (GFRa-2)

Target (abbrv.) GFRa-2
Target (full name) GDNF family receptor alpha-2
Somalogic ID (Sequence ID) SL004143 (2515-14_3)
Entrez Gene Symbol GFRA2
UniProt ID O00451
UniProt Comment
  • Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.
Reactome
  • NCAM1 interactions

All locus annotations are based on the sentinel SNP (rs4443656) and 20 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
  • GFRA2 GDNF family receptor alpha 2