HelmholtzZentrum munich
WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 304

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
CLM6 trans Discovery rs722414 12:89,937,437 G/A 0.23 994 0.405 0.052 2.3×10-14 1.090 1.6×10-12 1.2×10-7
CLM6 trans Replication rs2230281 12:89,917,518 G/A 0.22 337 0.351 0.074 3.1×10-6 1.100 2.3×10-5 0.003

 

Regional association plots

 

Boxplots and histograms for top associations

CMRF35-like molecule 6 (CLM6)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

CMRF35-like molecule 6 (CLM6)

Target (abbrv.) CLM6
Target (full name) CMRF35-like molecule 6
Somalogic ID (Sequence ID) SL014270 (5066-134_3)
Entrez Gene Symbol CD300C
UniProt ID Q08708
UniProt Comment
  • Cell membrane

All locus annotations are based on the sentinel SNP (rs722414) and 93 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by