HelmholtzZentrum munich
WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 397

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
IL-17E trans Discovery rs7121784 11:120,159,052 C/A 0.15 995 0.425 0.061 5.3×10-12 1.110 2.3×10-6 0.246
IL-17E trans Replication rs7121784 11:120,159,052 C/A 0.15 337 -0.016 0.092 0.86 -1.040 0.362 0.453

 

Regional association plots

 

Boxplots and histograms for top associations

Interleukin-25 (IL-17E)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Interleukin-25 (IL-17E)

Target (abbrv.) IL-17E
Target (full name) Interleukin-25
Somalogic ID (Sequence ID) SL004351 (4137-57_2)
Entrez Gene Symbol IL25
UniProt ID Q9H293
UniProt Comment
  • Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses.

All locus annotations are based on the sentinel SNP (rs7121784).
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
  • POU2F3 POU class 2 homeobox 3