Locus 409

GWAS results
Target annotations
Locus annotations
Network

Top associations per target

Target	cis/trans	Study	SNP	SNP location	Maj/min allele	MAF	N	β_inv	se_inv	P_inv	fc_log	P_log	P_raw
IL-1 R4	cis	Discovery	rs3917254	2:102,776,518	G/A	0.10	994	-0.440	0.064	1.2×10^-11	-1.200	3.8×10^-12	1.6×10^-6
IL-1 R4	cis	Replication	rs3917254	2:102,776,518	G/A	0.19	337	-0.174	0.086	0.043	-1.080	0.039	0.146

Regional association plots

Interleukin-1 receptor-like 1 (IL-1 R4)

Download the association data used to generate this plot

Boxplots and histograms for top associations

Interleukin-1 receptor-like 1 (IL-1 R4)

	inverse-normalized probe levels	log₂ transformed probe levels	raw probe levels
Discovery study
Replication study

Interleukin-1 receptor-like 1 (IL-1 R4)

Target (abbrv.)	IL-1 R4
Target (full name)	Interleukin-1 receptor-like 1
Somalogic ID (Sequence ID)	SL004146 (4234-8_2)
Entrez Gene Symbol	IL1RL1
UniProt ID	Q01638
UniProt Comment	Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.

All locus annotations are based on the sentinel SNP (rs3917254).
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by

IL1R1 interleukin 1 receptor, type I