Locus 418

GWAS results
Target annotations
Locus annotations
Network
Remarks

Top associations per target

Target	cis/trans	Study	SNP	SNP location	Maj/min allele	MAF	N	β_inv	se_inv	P_inv	fc_log	P_log	P_raw
IL-16	cis	Discovery	rs11072996	15:81,529,410	T/C	0.07	997	-0.537	0.079	2.1×10^-11	-1.130	5.2×10^-13	4.9×10^-9

Regional association plots

Interleukin-16 (IL-16)

Download the association data used to generate this plot

Boxplots and histograms for top associations

Interleukin-16 (IL-16)

	inverse-normalized probe levels	log₂ transformed probe levels	raw probe levels
Discovery study

Interleukin-16 (IL-16)

Target (abbrv.)	IL-16
Target (full name)	Interleukin-16
Somalogic ID (Sequence ID)	SL000474 (2774-10_3)
Entrez Gene Symbol	IL16
UniProt ID	Q14005
UniProt Comment	Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.
Pathway Studio	HRH2/4 → IL6/10 production Summarized nociception-related expression targets T-cell receptor → AP-1 signaling T-cell receptor → ATF/CREB signaling T-cell receptor → CREBBP signaling T-cell receptor → NF-kB signaling T-cell receptor → NFATC signaling T-cell receptor → STAT signaling

All locus annotations are based on the sentinel SNP (rs11072996).
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by

IL16 interleukin 16