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WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 422

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
NXPH1 trans Discovery rs668555 1:57,426,454 T/C 0.29 994 0.323 0.048 2.4×10-11 1.090 4×10-11 1.8×10-9
NXPH1 trans Replication rs658285 1:57,416,335 G/A 0.35 337 0.262 0.074 4.9×10-4 1.100 3×10-4 0.002

 

Regional association plots

 

Boxplots and histograms for top associations

Neurexophilin-1 (NXPH1)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Neurexophilin-1 (NXPH1)

Target (abbrv.) NXPH1
Target (full name) Neurexophilin-1
Somalogic ID (Sequence ID) SL012457 (4562-1_2)
Entrez Gene Symbol NXPH1
UniProt ID P58417
UniProt Comment
  • May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.

All locus annotations are based on the sentinel SNP (rs668555) and 5 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by