Locus 425

GWAS results
Target annotations
Locus annotations
Network

Top associations per target

Target	cis/trans	Study	SNP	SNP location	Maj/min allele	MAF	N	β_inv	se_inv	P_inv	fc_log	P_log	P_raw
Angiostatin	cis	Discovery	rs41265930	6:160,964,135	T/C	0.06	997	-0.564	0.084	3.4×10^-11	-1.080	3×10^-8	6.7×10^-5

Regional association plots

Angiostatin

Download the association data used to generate this plot

Boxplots and histograms for top associations

Angiostatin

	inverse-normalized probe levels	log₂ transformed probe levels	raw probe levels
Discovery study

Angiostatin

Target (abbrv.)	Angiostatin
Target (full name)	Angiostatin
Somalogic ID (Sequence ID)	SL000268 (3710-49_2)
Entrez Gene Symbol	PLG
UniProt ID	P00747
UniProt Comment	Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.
Targeted by drugs (based on IPA annotation)	tenecteplase PLAT tranexamic acid aprotinin 6-aminocaproic acid reteplase
Biomarker applications (based on IPA annotation)	diagnosis
Wiki Pathways	Blood Clotting Cascade Complement and Coagulation Cascades Folate Metabolism Selenium Pathway Vitamin B12 Metabolism
Pathway Interaction Database	Angiopoietin receptor Tie2-mediated signaling Syndecan-4-mediated signaling events Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling amb2 Integrin signaling p75(NTR)-mediated signaling
Reactome	Activation of Matrix Metalloproteinases Degradation of the extracellular matrix Dissolution of Fibrin Clot Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Signaling by PDGF
Pathway Studio	Coagulation Cascade ThrombinR → AP-1/CREB/ELK-SRF/SP1 signaling ThrombinR → NF-kB signaling ThrombinR → STAT1 signaling

All locus annotations are based on the sentinel SNP (rs41265930).
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by

LPA lipoprotein, Lp(a)