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WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 433

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
TARC trans Discovery rs2228467 3:42,906,116 T/C 0.07 995 0.551 0.083 4.2×10-11 1.170 4.8×10-12 7.1×10-10

 

Regional association plots

 

Boxplots and histograms for top associations

C-C motif chemokine 17 (TARC)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study

C-C motif chemokine 17 (TARC)

Target (abbrv.) TARC
Target (full name) C-C motif chemokine 17
Somalogic ID (Sequence ID) SL003196 (3519-3_2)
Entrez Gene Symbol CCL17
UniProt ID Q92583
UniProt Comment
  • Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.
Pathway Interaction Database
  • IL4-mediated signaling events
Reactome
  • Chemokine receptors bind chemokines

All locus annotations are based on the sentinel SNP (rs2228467).
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by