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WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 442

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
sTie-1 trans Discovery rs7857390 9:136,128,546 G/A 0.38 996 -0.295 0.045 5.8×10-11 -1.050 6.3×10-11 1.7×10-10
sTie-1 trans Replication rs7857390 9:136,128,546 G/A 0.34 337 -0.329 0.066 1×10-6 -1.080 4×10-6 1.5×10-5

 

Regional association plots

Tyrosine-protein kinase receptor Tie-1, soluble (sTie-1)

Download the association data used to generate this plot

 

Boxplots and histograms for top associations

Tyrosine-protein kinase receptor Tie-1, soluble (sTie-1)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Tyrosine-protein kinase receptor Tie-1, soluble (sTie-1)

Target (abbrv.) sTie-1
Target (full name) Tyrosine-protein kinase receptor Tie-1, soluble
Somalogic ID (Sequence ID) SL003199 (2844-53_2)
Entrez Gene Symbol TIE1
UniProt ID P35590
UniProt Comment
  • Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.

All locus annotations are based on the sentinel SNP (rs7857390) and 15 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
  • ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)