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WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 45

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
Granulysin cis Discovery rs12151621 2:85,934,499 C/A 0.21 995 0.902 0.045 5.8×10-76 1.380 1.4×10-74 3.1×10-78
Granulysin cis Replication rs7577293 2:85,935,282 G/A 0.23 337 0.732 0.081 1.1×10-17 1.360 1.3×10-17 8.8×10-18

 

Regional association plots

 

Boxplots and histograms for top associations

Granulysin

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Granulysin

Target (abbrv.) Granulysin
Target (full name) Granulysin
Somalogic ID (Sequence ID) SL000678 (3195-50_2)
Entrez Gene Symbol GNLY
UniProt ID P22749
UniProt Comment
  • Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis.

All locus annotations are based on the sentinel SNP (rs12151621) and 5 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes