HelmholtzZentrum munich
WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 64

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
FCRL3 cis Discovery rs7522061 1:157,668,390 T/C 0.43 994 0.676 0.040 5.4×10-57 1.100 1.2×10-15 0.112
FCRL3 cis Replication rs7522061 1:157,668,390 A/G 0.45 337 0.426 0.065 2.7×10-10 1.100 1.3×10-4 0.062

 

Regional association plots

 

Boxplots and histograms for top associations

Fc receptor-like protein 3 (FCRL3)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Fc receptor-like protein 3 (FCRL3)

Target (abbrv.) FCRL3
Target (full name) Fc receptor-like protein 3
Somalogic ID (Sequence ID) SL014088 (4440-15_2)
Entrez Gene Symbol FCRL3
UniProt ID Q96P31
UniProt Comment
  • Interacts with PTPN6, PTPN11, SYK and ZAP70.

All locus annotations are based on the sentinel SNP (rs7522061) and 12 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by