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WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 91

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
TXD12 trans Discovery rs4688759 3:50,008,118 T/C 0.10 997 0.959 0.067 1.8×10-42 1.270 1.4×10-39 9.2×10-46
TXD12 trans Replication rs9844757 3:49,343,601 A/C 0.05 337 0.865 0.154 4.2×10-8 1.260 5.1×10-7 9.9×10-7

 

Regional association plots

Thioredoxin domain-containing protein 12 (TXD12)

Download the association data used to generate this plot

 

Boxplots and histograms for top associations

Thioredoxin domain-containing protein 12 (TXD12)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Thioredoxin domain-containing protein 12 (TXD12)

Target (abbrv.) TXD12
Target (full name) Thioredoxin domain-containing protein 12
Somalogic ID (Sequence ID) SL016128 (4815-25_3)
Entrez Gene Symbol TXNDC12
UniProt ID O95881
UniProt Comment
  • Possesses significant protein thiol-disulfide oxidase activity.

All locus annotations are based on the sentinel SNP (rs4688759) and 19 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
  • BSN bassoon presynaptic cytomatrix protein
  • AMIGO3 adhesion molecule with Ig-like domain 3
  • GMPPB GDP-mannose pyrophosphorylase B
  • RNF123 ring finger protein 123
  • IP6K1 inositol hexakisphosphate kinase 1
  • RP13-1056D16.2
  • TRAIP TRAF interacting protein
  • RN7SL217P RNA, 7SL, cytoplasmic 217, pseudogene
  • CAMKV CaM kinase-like vesicle-associated
  • AC139451.2
  • ACTBP13 actin, beta pseudogene 13
  • RBM6 RNA binding motif protein 6
  • RBM5 RNA binding motif protein 5